WO2009057230A1 - Method for producing cytidine 5'-monophosphate - Google Patents

Method for producing cytidine 5'-monophosphate Download PDF

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WO2009057230A1
WO2009057230A1 PCT/JP2007/071755 JP2007071755W WO2009057230A1 WO 2009057230 A1 WO2009057230 A1 WO 2009057230A1 JP 2007071755 W JP2007071755 W JP 2007071755W WO 2009057230 A1 WO2009057230 A1 WO 2009057230A1
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Prior art keywords
atom
amino acid
cmp
leu
protein
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PCT/JP2007/071755
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French (fr)
Japanese (ja)
Inventor
Hisaya Tanaka
Akihiko Maruyama
Yoshiyuki Yonetani
Ritsuko Katahira
Shingo Kakita
Satoshi Mitsuhashi
Jun-Ichi Saito
Hideki Oda
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Kyowa Hakko Bio Co., Ltd.
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Priority to PCT/JP2007/071755 priority Critical patent/WO2009057230A1/en
Publication of WO2009057230A1 publication Critical patent/WO2009057230A1/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1077—Pentosyltransferases (2.4.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/305—Pyrimidine nucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/02—Pentosyltransferases (2.4.2)
    • C12Y204/02009—Uracil phosphoribosyltransferase (2.4.2.9)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Definitions

  • the present invention relates to a method for producing a novel protein having an activity of producing cytidine 5, monomonophosphate (CMP) from cytosine, the protein, a DNA encoding the protein, a recombinant DNA containing the DNA, the recombinant
  • CMP monomonophosphate
  • the present invention relates to a method for producing CMP using microorganisms that possess body DNA and cultures of the microorganisms.
  • CMP is used as an additive to infant milk with the other nucleotides adenosine 5, monomonophosphate (AMP), guanosine 5, monomonophosphate (GMP), uridine 5, monomonophosphate (UMP).
  • AMP monomonophosphate
  • GMP guanosine 5, monomonophosphate
  • UMP uridine 5, monomonophosphate
  • CMP has been produced by enzymatic degradation of yeast RNA (Non-patent Document 1).
  • this RNA dividing angle method has the disadvantage that four kinds of nucleotides are produced at the same time, resulting in a surplus in the product due to the difference between the production amount and the demand amount. For this reason, development of an inexpensive method for producing individual nucleotides is desired.
  • Enzymes involved in the salvage synthesis pathway include nucleotides corresponding to bases such as uracil phospholiposyltransferase (UPRTase), which catalyzes the reaction of UMi 5 and pyrophosphate from uracil and phosphoribosyl pyrophosphate (PRPP). Enzymes that produce succinamide in a single step are known. However, the salvage synthesis pathway enzymes that produce CMP are not known across all species.
  • UPRTase uracil phospholiposyltransferase
  • PRPP phosphoribosyl pyrophosphate
  • Non-Patent Document 1 J. Gen. Appl. Microbiol., 3, 55 (1957)
  • Patent Document 1 Japanese Patent Laid-Open No. 62-285797
  • Patent Document 2 Japanese Patent Laid-Open No. 2-13439 Disclosure of Invention
  • An object of the present invention is to provide a method for producing a novel protein having an activity of generating CMP from cytosine, the protein, a DNA encoding the protein, a recombinant DN A containing the DNA, and the recombinant DN A
  • An object of the present invention is to provide a method for producing CMP using a microorganism and a culture of the microorganism. Means for solving the problem
  • the present invention relates to the following (1) to (14). '
  • amino acid sequence represented by SEQ ID NO: 1, 2, or 30 one or more amino acid residues selected from the 36th, 94th, 102th, 141st, 143rd, 143rd, and 198th amino acid residues
  • a recombinant DNA comprising the DNA of (7) above.
  • microorganism (10) The microorganism according to (9) above, wherein the microorganism belongs to the genus Escherichia, the genus Corynebatarum, or the genus Brevibaterium. -
  • microorganism culture of (9) or (10) above or the treated product of the culture, cytosine, phosphate donor and energy donor are present in an aqueous medium, and A method for producing useful substances, characterized by using generated CMP.
  • the present invention also relates to the following (15) to (24).
  • a method for producing a protein having an activity of producing cytidine 5, monomonophosphate (CMP) from cytosine comprising the following steps:
  • a method for producing a protein having an activity of producing cytidine 5, monomonophosphate (CMP) from cytosine comprising the following steps:
  • CMP is applied to the UMP binding site in UPRTase on a computer.
  • a step of producing a UP RTase mutant protein comprising the deletion, substitution and / or addition selected in the steps [11] and [12].
  • amino acid sequence shown in SEQ ID NO: 15 the amino acid sequence has ⁇ to several amino acids deleted, substituted and Z or added,
  • UPRTase Part or all of the three-dimensional structural information of a protein (UPRTase) comprising the amino acid sequence of SEQ ID NO: 15 represented by the three-dimensional coordinate atomic coordinates described in Table 1 and having an activity of generating UMP from uracil.
  • substitution of an amino acid with a constituent atom in the range of 10 A from the oxygen atom of the oxo group at the 4-position of the pyrimidine ring of UMP substitution of amino acid that stabilizes the complex model of UP RTase and CMP created on the converter by converting the UMP group of UMP of the complex model into an amino group.
  • amino acid substitution is substitution of glycine at position 205 to aspartic acid or glutamic acid in the amino acid sequence represented by SEQ ID NO: 15. (twenty one)
  • amino acid substitution is substitution of tyrosine at position 201 and proline at position 204 of the amino acid sequence described in SEQ ID NO: 15.
  • amino acid substitution is substitution of tyrosine at position 201 to lysine and substitution of proline at position 204 to leucine in the amino acid sequence shown in SEQ ID NO: 15. '.. ⁇
  • UPRTase Part or all of the three-dimensional structural information of the protein (UPRTase) comprising the amino acid sequence described in SEQ ID NO: 15 represented by the three-dimensional coordinate atomic coordinates shown in Table 1 and having the activity of generating UMP from uracil
  • PRP P phosphoribosyl pyrophosphate
  • the present invention further includes a protein obtained by any one of the above-mentioned CP RTase production methods; a DNA encoding the protein; a recombinant DNA containing the DNA; a microorganism having the recombinant DNA;
  • the present invention relates to a process for producing useful substances produced using CMP and CMP as a substrate or via CMP.
  • FIG. 1 is a diagram showing the alignment results of amino acid sequences of various UPRTases.
  • Fig. 2 Mutant Escherichia coli with amino acid substitutions of G205D, M141L, and A143V
  • FIG. 3 is a diagram showing a tetramer model of a complex of Escherichia coli UPRTase and CMP. - ⁇ 'Best Mode for Carrying Out the Invention'
  • the protein (CPRTa se) having the activity of producing cytidine 5, monomonophosphate (CMP) from cytosine of the present invention is the protein (UPRTa se) having the activity of producing uridine 5′-monophosphate (UM P) from uracil. ) Can be obtained as a different protein.
  • the UPRTase mutated protein is a protein having an amino acid sequence in which one to several amino acids have been deleted, substituted and / or added in the amino acid sequence of UPRTase.
  • the number of pieces may be 30 pieces, preferably 20 pieces, and more preferably 5. '
  • the activity of generating cytidine 5, monophosphate (CMP) from cytosine means the activity of synthesizing CMP and pyrophosphoric acid from cytosine and PRPP.
  • CPRTa se may have the activity of synthesizing 11 ⁇ ? From uracil and P 1 ?? (UPRTa se activity), but it can be confirmed by the method described in the examples below.
  • the CPRTase activity is higher than the UPRTase activity, the CPRTase activity is more preferably 10 times higher than the UPRTase activity, and it has substantially no UPRTase activity. Further preferred.
  • amino acid mutations to be added to UPRTase for the production of CPRTase can be carried out by preparing mutant proteins at random and confirming the activity of those mutant proteins by the method described below.
  • Amino acid mutation or mutation is UP Means amino acid deletion, substitution and / or addition in addition to the RTase amino acid sequence.
  • the screening method is not particularly limited, for example, Py rG (CTP synthetase), co dA (cytosine deamidation) using a recombinant DNA containing a DNA encoding a protein having an arbitrary mutation. ), Cdd (Cytidine deaminase) E. coli which has lost the three enzyme activities transformed, and whether the resulting transformant grows in a cytosine-containing minimal medium as an indicator Alternatively, it may be carried out by producing a protein having an arbitrary mutation, quantifying the amount of CMP produced, and confirming CPRTase activity.
  • Another method for selecting amino acid mutations to be added to UPRTase for the production of CPRTase is to use a computer model created on the basis of the three-dimensional structure information of UPRTase. Can be mentioned.
  • the three-dimensional structure information of UPRTase any information available to those skilled in the art may be used. Structure information obtained by crystal structure analysis or structure information obtained from a database such as PDB (Protein Data Bank) is used. Alternatively, the structure information created by using a protein homology model creation program such as Insight 97 with the structure as a saddle may be used. Further, the three-dimensional structure information may be information on UPRTase monomer, and may be information on a multimer such as a dimer or a tetramer. Furthermore, the three-dimensional structure information may relate to a part of the UPRTase monomer or multimer, but preferably includes information on the UMP binding site described below. In addition, when the above three-dimensional information is used to create a multimeric model, it is preferable to include information on the boundary between monomers.
  • a composite model of UPRTase and CMP can be created using the above-described three-dimensional structural information of UPRTase.
  • the entire 3D structure information or a part of it may be used.
  • a site considered to be involved in stabilization of the complex of UPRTase and CMP may be selected in advance, and a complex model including the site may be created.
  • UPRTase which uses three-dimensional structural information and is the basis for mutation, may be any protein that has the activity to produce uridine 5'-monophosphate (UMP) from uracinole, and the organism from which it is derived is particularly limited. Not. Examples of derived microorganisms include Acholeplasma laidlawii (J Bacteriol. (1983) 156: 192-7 Crithidia luciliae (Comp Biochem Physiol B. (1990) 95: 159-63.) Escherichia coli (Biochim Biophys Acta. (1986) 881 268-75.Genbank Accession No X57104) Bacillus caldolyticus (J Bacteriol.
  • the hydrogen bond with the hydrogen atom at the position and the amide hydrogen atom of the 22nd 9th isoleucine form a hydrogen bond with the oxygen atom at the 4-position of the pyrimidine ring, thereby stabilizing the bond with the pyrimidine ring of UMP. ing.
  • the UMP binding site can also be determined for other types of UPRT as. Specifically, alignment of the amino acid sequence of UPRT ase derived from Toxoplasma gondii and the amino acid sequence of UPRT ase using three-dimensional structural information (ClustalW [Nucelic Acids Research 22, 4673, (1994)] (European Bioinformatics Institute website (http:. Ebi. Ac. Uk / clustalw), alignment analysis software included in Genetyx (Software Development Co., Ltd.) 3D structure information UMP binding The site can be determined. Default values can be used as analysis software parameters for alignment.
  • UPRT ase derived from Toxoplasma gondii and Escherichia coli shows an example of alignment of amino acid sequences of various UPRTases including UPRT ase derived from Toxoplasma gondii and Escherichia coli. From this result, in UPRT ase derived from EschericMa coli, isoleucine at position 202, glycine at position 107, alanine at position 209, etc. are considered to be involved in the binding of the pyrimidine ring of UMP.
  • CMP can be adapted on the computer to the above UMP coupling site.
  • Examples of methods for adapting CMP to the UMP binding site include the following methods. Dock UMP to UPRT ase from Escherichia coli After selecting the structure that has already been reported for UPRTase derived from xoplasma gondii and adopting the conformation in which the hydrogen bond of UMP pyrimidine ring and WPRTase is maintained, it was created by minimizing the energy of the complex.
  • the UMP complex model is used. In the above complex model, oxygen in the 4-position carbonyl group of the pyrimidine ring of UMP is substituted with an amino group, and hydrogen at the 3-position of the pyrimidine ring is removed, so that UMP is converted to CMP as CMP. Further, repeat energy minimization calculation is performed for the model.
  • a complex model of UPRT as and CMP can be created by adapting CMP to the UMP binding site.
  • stabilizing the model means, for example, reducing ⁇ AG.
  • AG free energy change
  • AAG is the complex of UPRTase and CMP here. It means the ⁇ G force calculated from the structure minus the AG calculated from the complex structure of mutant UPRTase and CMP.
  • the AG difference between the model before and after the mutation is calculated on the converter, and the energy level after the amino acid mutation is 5 kJ / mo 1, It can be carried out by selecting a mutation that preferably decreases by 20 kJ / mo 1, more preferably 50 kJ / mo 1 or more. Such calculations can be performed with the docking program Glide.
  • mutations such as amino acid substitutions that stabilize the model can be selected between model components (such as between UPRT ase and CMP in a complex model of UPRT ase and CMP, or between monomers in a multimeric model). ) Can be used as an index. That is, a mutation that increases the affinity between components may be selected.
  • 'Selection of mutations that increase affinity can be done, for example, by visual observation of the model. Hydrophobic interaction between structural elements (UPRT ase and CMP, between monomers, etc.) in the model, ⁇ electrostatic interaction ⁇ hydrogen bonding ⁇ ⁇ / ⁇ interaction (magnetic field generated by ring current of aromatic ring) Interaction) 'CH / ⁇ interaction (Interaction of the ring current of the aromatic ring and the magnetic field generated by the electrons of the methyl group) 1 Select a mutation that increases or enhances. [0030] In the complex model of UPRTase and CMP, specifically, in order to stabilize the model, mutations can be selected first by focusing on the structural differences between UMP and CMP.
  • UMP and CMP differ at the 4-position of the pyrimidine ring, except that UMP is an oxo group and CMP is an amino group. Therefore, for example, in the UPRTase where the center of the constituent atom exists in the vicinity of the 4-position amino group of the pyrimidine ring of CMP (about 1 OA, preferably about 8 A, more preferably about 5 A from the center of the nitrogen atom of the amino group). Affinity between UPRTase and CMP can be increased by changing the amino acid residue to an amino acid residue that interacts with the CMP amino group. In addition, in this specification, when showing the distance between atoms, the distance between the centers of atoms is shown.
  • the distance between atoms can be measured by tapping and selecting two atoms to be measured in the model displayed on graphics by Insight 97.
  • UMP and CMP differ in whether the nitrogen atom at the 3-position of the pyrimidine ring has a hydrogen atom.
  • the UPRT ase in which the center of the constituent atom exists in the vicinity of the nitrogen atom at the 3-position of the pyrimidine ring of CMP (about 10 A, preferably about 8 A, more preferably about 5 A from the center of the nitrogen atom).
  • Affinity between UPRTase and CMP can be increased by changing the amino acid residue to an amino acid residue that interacts with the CMP amino group.
  • a complex model of UPRT ase and UMP can also be used to select mutations that stabilize the complex model of UPRT ase and CMP. Since the binding position of UMP and CMP is considered to be almost the same, by using the complex model of UMP and UPRT ase created directly from the above 3D structure information, it is practically This is because amino acids involved in CMP and UPRTase interaction can be selected.
  • an amino acid residue in the vicinity of the 4-position oxo group of the pyrimidine ring of UMP (the center of the constituent atom is about 10 A, preferably about 8 A, more preferably about 5 A from the center of the oxygen atom of the oxo group). Can be selected.
  • the amino acid after mutation may be selected assuming that the 4-position oxo group of the pyrimidine ring is replaced with an amino group.
  • an amino acid residue in the vicinity of the nitrogen atom at the 3-position of the pyrimidine ring of UMP (amino acid residue in which the center of the constituent atom exists about 10 A, preferably about 8 A, more preferably about 5 A from the center of the nitrogen atom) ) Can be selected.
  • the amino acid after mutation may be selected assuming that there is no hydrogen atom bonded to the nitrogen atom at the 3-position of the pyrimidine ring.
  • a complex model of UPRTase and cytosine or uracil can also be used to select mutations that stabilize the complex model of UP.RTase and CMP.
  • EMBO J. (1998) 17: 3219-3232 mentioned above, the uracil bond in UPRTase is reported.
  • a complex model of UP RTase and 'cytosine or uracil is created, and these complex models are prepared by the method described above. Select a mutation that stabilizes Dell.
  • CPRTase For production of CPRTase, create a complex model of UPRTase and CMP with the mutation selected as above, and select additional amino acid mutations that stabilize the model. You can do it. Alternatively, based on the amino acid sequence of the mutant UPRTase having the mutation selected using any of the above complex models, random screening can be performed to obtain a more active CP RTase. . ,
  • DNA having a mutation selected above is used as a saddle type DNA encoding the mutation UPRTase, and DNA having a random mutation is prepared by an error prone PCR method or the like. Screening can be performed using transformants prepared using recombinant DNA containing A.
  • UP RT ase and CMP complex model In addition to the above-mentioned UP RT ase and CMP complex model and UPRT ase and UMP complex model, other models are selected in addition to the variation selected by focusing on structural differences between UMP and CMP. Mutations that stabilize can be selected. It is preferable that other mutations coexist with mutations selected by focusing on the structural differences between UMP and CMP. As another option, for example, in a complex model of UPRTase and CMP, about 1 OA is preferred from the center of any atom constituting CMP. The center of the constituent atom is preferably in the range of about 8 A, more preferably about 5 A. U
  • the amino acid residue of PRTase may be changed to an amino acid residue that interacts with the CMP amino group.
  • the center of the constituent atom exists in the range of about 10 A, preferably about 8 A, more preferably about 5 A from the center of any atom constituting UMP.
  • the amino acid residue of UPRTase can be selected as an amino acid residue to be mutated.
  • UPRT ase usually forms a dimer, but GTP binds to form a tetramer, and it is known that amino acids that interact with PR PP increase and UPRT ase activity increases (Proc Natl. Acad. Sci. USA (2002) 99: 78-83.).
  • amino acid mutations added to UP RT as for the production of CPRT as can also be carried out by selecting mutations that stabilize UPRT as or the multimeric model of any of the aforementioned complexes.
  • Mutations that stabilize the multimeric model include examining the amino acids at the boundary between each monomer on computer graphics and energeticly unstable elements between them (for example, electrostatic repulsion, steric repulsion). Etc.) can be mutated to remove unstable elements or to strengthen the interaction. For example, an amino acid having a center of the constituent atom in the range of about 10 A, preferably about 8 A, more preferably about 5 A from any atom of the adjacent UP RTase monomer is added to the adjacent atom. It can be changed to amino acid residues that interact with the monomer of UPRTase.
  • the multimer model may be created based on the three-dimensional structure information of UPRTase, or preferably one of the above-mentioned complex models. In particular, since the multimeric structure is thought to contribute to increasing the binding site with the substrate, it is preferable to create the multimeric model using all or part of the complex model of UPRTase and PRPP. ,. [0040]
  • the mutant protein of UP RTase obtained as CPRTase is a mutation introduced as a side effect, or a substitution to a mutually convertible amino acid as described below. Other mutations such as may be included.
  • the production method of the mutant protein is not particularly limited, it can be produced by a method using gene recombination described in the production of a specific protein described later.
  • the “other amino acid residues” in the above (b) and (d) may be either natural or non-natural amino acids.
  • Natural amino acids include L-alanine and L-a. Sparagin, L-aspartic acid, L-glutamine, L-glutamic acid, glycine, L-histidine, L-isoleucine, L-sip Icine, L-lysine, L-arginine, L-methionine, L-phenenolealanine, L-proline, -L-serine, L-threonine, L-tryptophan, L-tyrosine, L-valine, L-cysteine, etc.
  • the 36th amino acid residue is cysteine
  • the 9th amino acid residue is tyrosine or phenylalanin
  • the 100th second amino acid residue is cysteine
  • the first amino acid residue is leucine, isoorcinine, nonoleucine, norin, nonolevaline, alanine, 2-aminobutanoic acid, methionine, O-methylserine, t-butylglycine, t-ptylalanin opicyclohexylalanine
  • 1 4 3rd amino acid residue is parin, leucine, isoleucine, norleucine, norvaline, alanine, 2-aminobutanoic acid, methoyun, 0-methylserine, t-butylglycine, ⁇ -butylalanine and
  • the amino acid selected from hexylalanin, 1 9 8th amino acid residue is glyc Can be
  • amino acids that can be substituted for each other in the protein (d) are shown below. Amino acids included in the same group can be substituted for each other.
  • Group A Leucine, isoleucine, norleucine, valine, nonoleparin, arayun, 2-aminobutanoic acid, methionine, O-methylserine, t-butylglycine, t-ptylalananine, cyclohexinolealanine
  • Group B Aspartic acid, Gudamic acid, Isospartic acid, Isoglutamic acid, 2-Aminoadipic acid, 2-Aminosuberic acid
  • Group C asparagine, glutamine,
  • Group D Lysine, Arginine, Ornitine, 2,4-Diaminobutanoic acid, 2,3-Diaminopropionic acid
  • Group F serine, thread-retained nin, homoserine
  • Group G phenenolealanine, tyrosine
  • the above proteins (b) and (d) have the activity of generating CMP from cytosine.
  • the DNA of the present invention includes the DNAs described in the following (e) and (f)
  • the DNA of the present invention can be obtained by introducing a mutation into DNA encoding UPRT ase derived from Escherichia colO.
  • a chromosomal DNA (SEQ ID NO: 6) is prepared from Escherichia coli W3110 strain, and the DNA having the nucleotide sequence represented by SEQ ID NOs: 7 and 8, for example, is chemically synthesized using the DNA as a cage. It can be obtained by PCR using DNA as a primer set. Specific examples of DNA that can be obtained by the above method include DNA having the base sequence represented by SEQ ID NO: 5. ,
  • DNA encoding UPRTase derived from Escherichia coli can also be obtained by the hybridization method using part or all of the DNA consisting of a base sequence complementary to the base sequence represented by SEQ ID NO: 5 as a probe. can do.
  • the hybridization method can be performed in accordance with the method described in Molecular Cloning, A Laboratory Manual, Third Edition, Cold Spring Harbor Laboratory Press, 2001 (hereinafter abbreviated as “molecular cloning”).
  • DNA encoding UPRT ase derived from Escherichia coli can also be obtained by chemically synthesizing DNA having the base sequence by a known method based on the base sequence represented by SEQ ID NO: 5.
  • the DNA of the present invention can be obtained by using molecular cloning and Current Protocols in Molecular Biology, John Wiley & Sons (1987-1997) (hereinafter referred to as current protocol). Mouth Tocoles in. Molecular. Biology) etc. Subordinates can be obtained by introducing site-specific mutations. It can also be obtained by introducing random mutations into DNA having the nucleotide sequence represented by SEQ ID NO: 5 by the error-prone PCR method [Proc. Natl. Acad. Sci. USA, 90, 5618 (1982)]. be able to.
  • a complex structure of UPRT ase and UMP such as Toxoplasma gondi i and Bacillus caldolyticus derived from various organisms is used as a mirror structure to create a homology model of E. coli and based on this model.
  • the amino acid residues near the UMP binding site are extracted, and the amisic acid residues that are assumed to play an important role in converting substrate specificity from uracil, which is the original substrate, to cytosine are selected. It is also possible to select a protein having an activity of converting cytosine into CMP by introducing a site-specific mutation. For details, refer to the description of the item “CPR T a s design” above. '
  • the protein of the present invention of 1 above is obtained by using the method described in Molecular 'Cloning Current Protocols' In'Molecular' Bio Mouth, etc., for example, by the following method. It can be produced by expressing DNA in a host cell.
  • a DNA fragment of an appropriate length containing a portion encoding the protein of the present invention is prepared.
  • Recombinant DNA inserted downstream of the expression vector promoter is prepared.
  • a transformant can be prepared by introducing the recombinant DNA into a host cell suitable for the expression vector.
  • the protein of the present invention can also be efficiently produced by preparing a DNA in which the nucleotide sequence of the DNA fragment is substituted with a base so that it becomes an optimal codon for host cell expression.
  • Any host cell can be used as long as it is capable of expressing the target gene.
  • the expression vector a vector that can replicate autonomously in the above host cell and contains a promoter at a position where the DNA encoding the polypeptide of the present invention can be transcribed is used.
  • the recombinant vector containing the DNA encoding the protein of the present invention is capable of autonomous replication in the prokaryotic organism, and at the same time a promoter, a ribosome binding sequence, DNA of the present invention, transcription termination sequence, A constructed vector is preferred.
  • a gene that controls the promoter may also be included.
  • the promoter may be any as long as it functions in the host cell.
  • tr promoter P trD _
  • lac promoter P L promoter
  • P R-flops opening motor such as T7 promoter, E. coli and file - it is possible to increase the promoter derived from the di-like.
  • Artificially modified promoters such as a promoter in which two P trDs are connected in series (P trD X 2), tac promoter, lacT7 promoter, let I promoter, etc. can also be used.
  • a transcription termination sequence is not necessarily required for expression of the DNA of the present invention, but a transcription termination sequence is preferably arranged immediately below the structural gene.
  • Host cells include microorganisms belonging to the genus Escherichia, the genus Corynepacteria 1 ⁇ 2 orynebacterium, or Brevibacterium, For example, Escherichia coli ⁇ Corynebacterium ammoniagenes. Escherichia coli DH1, Escherichia coli DH5 Escherichia coli MC1000, Es cherichia coli MM294, Escherichia coli ⁇ 1485, Escherichia coli JM109, Esc herichia coli thigh 01, Escherichia coli No.
  • Corynebacterium ammoniagenes ATCC21170, Corvnebacterium glutamic um ATCC13032, Corynebacterium glutamicum ATCC21171, Brevibacterium immarn ophilum ATCC14068, Brevibacterium saccharolyticum .ATCC14066, Brevibacteri uin flavum ATCC14067, Mashiku can be mentioned Corynebacterium ammoniagenes ATCC21170, Coryneb acterium glutamicum ATCC21171.
  • any method can be used as long as it is a method for introducing DNA into the above host cell.
  • a method using calcium ions [Proc. Natl. Acad. Sci. USA, 69, 2110 (1972)], protoplast method (JP 57-18649 2 and JP 57-18649), electroporation [for example, Journal of Bacteriology, 175, 4096 (1993), Appl. Microbiol Biotechnol., 52, 541 (1999)], Gene, 17, 107 (1982) and Molecular & General Genetics, 168, 111 (1979).
  • the protein of the present invention can be produced as a secretory product or a fusion protein according to the method described in Molecular Cloning.
  • the protein of the present invention can be obtained by culturing the transformant obtained by the above method in a medium, producing and accumulating the protein of the present invention in the culture, and collecting the protein of the present invention from the culture. Can do.
  • the culture of the transformant can be carried out by a 'normal culture method.
  • a natural source or a synthetic medium may be used as long as it contains a carbon source, a nitrogen source, an inorganic salt, and the like that can be assimilated by the transformant and can efficiently culture the transformant. Any of them may be used.
  • the carbon source include saccharides such as glucose, fructose, sucrose, maltose, and starch hydrolysate, alcohols such as ethanol, and organic acids such as acetic acid, lactic acid, and succinic acid.
  • the concentration is preferably 5 to 400 g / l.
  • Nitrogen sources include ammonia, ammonium chloride, ammonium sulfate, ammonium carbonate, ammonium acetate, various organic organic ammonium salts, urea, other nitrogen-containing compounds, meat extract, yeast extract, corn steep 'Nitrogen-containing organic substances such as liquor and soybean hydrolyzate can be used.
  • the concentration is preferably 1 to: L00 g / 1.
  • potassium hydrogen phosphate potassium dihydrogen phosphate, ammonium sulfate, sodium chloride, magnesium sulfate, calcium carbonate and the like can be used. .
  • micronutrient sources such as piotin and thiamine can be added as needed. These micronutrient sources can be substituted with natural products such as meat extract, yeast extract, corn 'steep' liquor and casamino acids.
  • Cultivation is performed under aerobic conditions such as shaking culture and deep aeration stirring culture.
  • Culture temperature is 2 0 ° C ⁇ 50 ° C, preferably preferably 30 ° C ⁇ 42 ° C, P H in the medium, 4: 10, preferably is maintained at 5-8. Adjust the pH with inorganic or organic acids, alkaline solutions, urea, calcium carbonate, ammonia, etc.
  • the culture time is 12 hours to 6 days, preferably 1 to 3 days.
  • an antibiotic such as kanamycin may be added to the medium as necessary during the culture. - ⁇ 0 0 5 9 ⁇ '
  • an inducer may be added to the medium as necessary.
  • an inducer may be added to the medium as necessary.
  • a microorganism transformed with a recombinant vector using a plug motor a microorganism transformed with a recombinant vector using isopropyl 1 ⁇ 1 D-thiogalactoviranoside, etc., with a trp promoter
  • indoleacrylic acid or the like may be added to the medium.
  • Production of the protein of the present invention there are a method of producing in the host cell, a method of secreting it outside the host cell, and a method of producing it on the host cell outer membrane.
  • the protein of the present invention When the protein of the present invention is produced in the host cell or on the outer membrane of the host cell, the method of Paulson et al. Biol. Chem., 264, 17619 (1989)), the method of Lou et al. [Proc. Sci. USA, 86. 8227 (1989), Genes Develop., 4.1288 (1990)], and Alternatively, by applying the method described in JP-A-5-336963, W094 / 23021 etc., the protein can be actively secreted outside the host cell.
  • the protein of the present invention can be actively expressed outside the host cell by expressing the polypeptide containing the active site of the protein of the present invention with a signal peptide added in front of it. Can be secreted.
  • the production amount can be increased by using a gene amplification system using a dihydrofolate reductase gene or the like.
  • the protein of the present invention when expressed in a dissolved state in cells, after completion of the culture, the cells are collected by centrifugation, suspended in an aqueous buffer, and then an ultrasonic breaker, French press, Mantongaurin. The cells are broken with a homogenizer, dynominole, etc. to obtain a cell-free extract. From the supernatant obtained by centrifuging the cell-free extract, ordinary enzyme isolation and purification methods, that is, solvent extraction methods, salt praying methods using ammonium sulfate, desalting methods, precipitation methods using organic solvents, etc.
  • Jetylaminoethyl (DEAE) — Sepharose anion exchange chromatography using resin such as M AION HPA-75 (Mitsubishi Kasei), resin such as S-Sepharose FF (Pharmacia) Cation exchange matrix chromatography method, hydrophobic chromatography method using resins such as butyl sepharose and phenyl sepharose, gel filtration method using molecular sieve, affinity matrix method, chromatofocusing method
  • a preparation or a purified preparation can be obtained by using a method such as electrophoresis such as isoelectric focusing alone or in combination.
  • the cell is recovered in the same manner, and then crushed and centrifuged to recover the protein insoluble substance as a precipitate fraction. Can do. Solubilize the recovered protein insolubles with a protein denaturant.
  • the protein can be returned to a normal three-dimensional structure by diluting or dialyzing the solubilized solution and reducing the concentration of the protein denaturant in the solubilized solution. After the operation, a purified preparation of the protein can be obtained by the same isolation and purification method as described above. .
  • the protein of the present invention or a derivative such as a protein having a sugar chain added to the protein is secreted outside the cell, the protein or the protein derivative can be recovered in the culture supernatant. That is, the culture is treated by a method such as centrifugation as described above. Thus, a purified preparation can be obtained from the culture supernatant by using the same isolation and purification method as described above.
  • a culture of the transformant obtained by the above method 4 or a processed product of the culture, cytosine, a phosphate group donor and an energy donor are present in an aqueous medium, and CMP is generated and accumulated in the medium.
  • the CM P can be acquired by collecting the CM P from the medium. .
  • a culture of the transformant obtained by the above method 4 or a treated product of the culture, a culture of a microorganism belonging to the genus Corynepacteria, or a treated product of the culture, cytosine, a phosphate group donor, and CMP can also be obtained by allowing an energy donor to be present in an aqueous medium, generating and accumulating C-MP in the medium, and collecting CMP from the medium.
  • the transformant is used as wet cells at a concentration of 0.5 to 500 g / l, preferably 5 to 20 Og / 1.
  • the cytosine used as a substrate may be a synthetic product or a natural product. Moreover, as long as it contains cytosine, it may be a purified product or a cytosine-containing crude product obtained from a natural product. Cytosine is used at a concentration of 1-100 g / l, preferably 1-50 g / l.
  • Examples of energy donors include carbohydrates such as gnolecose, fragose, sucrose, molasses, starch hydrolysate, organic acids such as pyruvic acid, lactic acid, acetic acid, ⁇ ; -ketoglutaric acid, amino acids such as glycine, alanine, aspartic acid, glutamic acid, etc. Any of the above-mentioned transformants can be used as long as they are metabolized and can generate sputum or the like in the cell. These are used at a concentration of 5 to 200 g / l.
  • Phosphoric acid group donors include orthophosphoric acid, pyrophosphoric acid, tripolyphosphoric acid, tetrapolyphosphoric acid, polyphosphoric acid such as tetrapolymetaphosphoric acid, polymetaphosphoric acid, monolithic phosphate, dipotassium phosphate, monosodium phosphate, Examples thereof include inorganic phosphates such as disodium phosphate. These are used at a concentration of 1-50 g / l.
  • microorganisms belonging to the genus Corynebacterium include Corynebacterium ammoniagenes and Corynebacterium glutamicum, and more preferably rynebacterium ammoniagenes ATCC6872, Corynebacterium ammoniagenes ATCC211 70, Corynebacterium glutamicum ATCC13032, Corvnebacterium glutamicum ATCC 21171 etc. can be raised.
  • Microorganisms belonging to the genus Corynebacterium can be cultured by the same method as described in 4 above.
  • a microorganism belonging to the genus Corynepacteria is used as a wet cell in a concentration of 0.5 to 500 g / l, preferably 5 to 200 g / l.
  • aqueous medium examples include aqueous solutions containing salts that do not inhibit the CMP production reaction, such as water, phosphate buffer, tris buffer, and borate buffer.
  • aqueous solutions containing salts that do not inhibit the CMP production reaction such as water, phosphate buffer, tris buffer, and borate buffer.
  • the supernatant of a culture obtained by culturing a transformant or a microorganism belonging to the genus Corynebataterium can be used as an aqueous medium as it is.
  • a surfactant or an organic solvent may be added to the aqueous medium as necessary.
  • the production efficiency of CMP can be increased by adding a surfactant or an organic solvent.
  • surfactants examples include polyethylene dallicol stearylamine (for example, Nimene S-215, manufactured by Nippon Oil & Fats Co., Ltd.), alkyldimethylbenzyl ammonium chloride (for example, Sarsol B-50, manufactured by Kao Corporation), etc.
  • Nonionics such as cationic surfactants, anionic surfactants such as sodium lauryl sulfate (for example, Persoft SL, manufactured by NOF Corporation), polyethylene glycol sorbitan monostearate (for example, nonion ST221, manufactured by NOF Corporation)
  • Amphoteric surfactants such as ionic surfactants, dimethyl lauryl betaine (for example, Nissannon BL, manufactured by Nippon Oil & Fats Co., Ltd.), and these are usually 0.1 to 20 g / l, preferably l to 10 g / l. Used at a concentration of l.
  • organic solvent examples include toluene, xylene, aliphatic alcohol, acetone, and ethyl acetate, and these are usually used at a concentration of 0.1 to 50 ml / l; preferably 1 to 20 ml / l.
  • the production reaction of CMP is carried out under aerobic conditions such as by aeration stirring.
  • the reaction temperature is maintained at 20 ° C. to 50 ° C., preferably 30 ° C. to 42 ° C., and the pH in the medium is maintained at 4 to 10, preferably 5 to 8.
  • the pH is adjusted using inorganic or organic acids, alkaline solutions, urea, calcium carbonate, ammonia, etc.
  • the reaction time is usually 1 to 48 hours.
  • CMP can be isolated and purified from the reaction solution obtained by removing precipitates such as bacterial cells by using a known method such as activated carbon treatment or ion exchange resin treatment.
  • CMP can be used.
  • useful substances produced as described above include cytidine 15′-triphosphoric acid, CMP-sialic acid, CDP-choline and the like.
  • Examples of methods for producing cytidine 15′-triphosphate using CMP as a substrate include the methods described in JP-A-2002-085087 and JP-A-2000-217593.
  • Examples of methods for producing sialic acid include the methods described in JP-A-5-76973, TO2004009830 and JP-A-2002-085087.
  • Examples of methods for producing CDP-choline include For example, the methods described in JP-A-63-313594 and JP-B-48-2358 can be mentioned.
  • a host fungus MC1000 A codA Acdd ApyrG:: Km was constructed as follows to detect the enzyme activity for producing CMP from cytosine and phosphoribosyl pyrophosphate (PRPPP).
  • PRPPP phosphoribosyl pyrophosphate
  • a strain lacking the codA gene and cdd gene on the chromosomal DNA of Escherichia coli MClOOO can be obtained by a method using the homologous recombination system of lambda phage (Proc. Natl. Acad Sci. USA, 97, 6640-6645 (2000) ).
  • Plasmids pKD46, pKD3, pD4 and pCP20 were obtained from Escherichia coli strains carrying the plasmid obtained from the Escherichia coli genetic stock center (Yale University, USA) and extracted from the Escherichia coli.
  • nucleotide sequence containing the Escherichia coli codA gene represented by SEQ ID NO: 6 the nucleotide sequence portion represented by nucleotide numbers 1-1031 to 2094-3105 was amplified by PCR reaction. These amplified fragments are obtained by amplifying DNA using the DNA sequence consisting of the nucleotide sequences represented by SEQ ID NOs: 7 and 8 as a primer set with pKD4 as a saddle and having an FRT (FLP recognition target) site.
  • FRT FLP recognition target
  • the ligated fragment was introduced into an Escherichia coli MC1000 strain into which PKD46 had been introduced in advance and Red recombinase was induced and induced by electroporation. Transformants were selected using the resistance to namycin as an index, and a strain in which the aph gene was inserted into the codA gene on the chromosome to disrupt the gene was obtained.
  • the base sequence portion represented by base numbers 1-1011 and 1656-2572 was amplified by PCR reaction.
  • These amplified fragments are cats with FRT sites at both ends, obtained by amplifying pKD3 in a saddle type and using DNA consisting of the nucleotide sequences represented by SEQ ID NOs: 10 and 11 as a primer set. (chloramphenicol acetyltransf erase) 3 ⁇ 4 Gene fragments were ligated.
  • the ligated fragment was introduced by electroporation into the force-namaicin resistant strain obtained as described above in which ⁇ Red recombinase was inducibly expressed.
  • a transformant was selected based on kanamycin opichlorfumicoleicol resistance as an index, and a strain in which the gene was disrupted by insertion of the cat gene into the gene on the chromosome was obtained.
  • pCP20 After removing PKD46 from the kanamycin opichloramphenicol resistant strain obtained above, pCP20. was introduced and FLP recombinase was induced and cultured, and then the chromosomal DNA ⁇ ! And the cat gene were removed. The strains were selected using kanamycin opichlorchlorphenicol sensitivity as an index, and then pCP20 was removed.
  • the strain obtained by the above operation is 1032-2093 in the nucleotide sequence represented by SEQ ID NO: 6 on the chromosomal DNA of Escherichia coli MC1000 strain, and 1012 in the nucleotide sequence represented by SEQ ID NO: 9.
  • -The Escherichia coli MC1000 strain lacking the portion corresponding to the base sequence represented by the 1655th, ie, lacking the codA gene and the cdd gene, and was named Escherichia coli MClOOOAcodAAcdd did.
  • a DNA consisting of the nucleotide sequence represented by SEQ ID NO: 12 that is part of the pyrG gene is prepared according to a conventional method, and between the BamHI recognition site and 1 recognition site of UC19. Connected.
  • the obtained recombinant plasmid DNA was digested with and then smoothed, and PUC4K (purchased from Amersham Biosciences) was digested with 2 ⁇ sHI and smoothed, and contained about aph gene derived from pUC4K. 1. Ligated with a 3 kb DNA fragment. The obtained plasmid DNA was digested with ⁇ HI and 3 ⁇ 4nl and then purified to obtain a defective pyrG gene fragment in which the aph gene was inserted into the pyrG gene and the gene was disrupted.
  • the DNA fragment was introduced into Escherichia coli JC7623 by electroporation, a transformant was selected using kanamycin resistance as an indicator, and a strain exhibiting cytidine requirement was isolated.
  • a PI lysate was prepared from a strain isolated, infected with Escherichia coli MM294 strain by selecting a strain showing resistance to kanamycin, chromosomal DN A by a P gene is ⁇ the pyrG gene
  • the above strain in which the gene was disrupted was obtained, and the strain was named Escherichia coli MM294ApyrG :: Km.
  • Escherichia coli MC1000 AcodA Acdd ApyrG Km strain is Cytidine-required, M 9 minimal agar medium containing 50 mg / 1 cytosine [Glucose 1.8 g, Sodium monohydrogen phosphate 6 g, Hydrogen dihydrogen phosphate 3 g, Sodium salt 0.5 g , ammonium chloride lg, magnesium sulfate heptahydrate 0.25 g, calcium chloride dihydrate 15 mg, thiamine hydrochloride 10 mg, Agar-Noble (Difco) '20 g in water It was confirmed that it was not able to grow with [Included in 11].
  • the mutant enzyme in the transformant obtained by introducing a plasmid expressing mutant type 1;? 1 and se into Escherichia coli MCI 000 AcodA AcddA y ⁇ :: & 11, the mutant enzyme generates CMP from cytosine. It can grow on M9 minimal medium containing cytosine only if it has the activity to do so.
  • chromosomal DNA of Escherichia coli W3110 strain is prepared by a known method, and then the chromosomal DNA is used as a saddle and DNA comprising the nucleotide sequence represented by SEQ ID NOs: 13 and 14 is used as a primer set. PCR was performed using Pyrobest DNA polymerase (Takara Shuzo).
  • the DNA fragment was ligated using the expression vector pTrc99A (manufactured by Pharmacia), also cleaved with EcoRI and BamHI, using DNA Ligatin Kit ver. 2.0 (manufactured by Takara Shuzo), and the resulting conjugate was used. Escherichia coli DH5a (Toyobo Co., Ltd.) was transformed.
  • a transformant was selected using ampicillin resistance as an indicator, and the obtained transformant was cultured overnight in an LB medium containing ⁇ g / ml ampicillin.
  • Plasmid DNA is prepared from the obtained culture using Qiagen Plasmid Miniprep Kit (manufactured by Qiagen), and the nucleotide sequence is analyzed. As a result, the plasmid contains approximately 0% of the Escherichia coli UPRT ase gene. It was confirmed that the plasmid had a structure with a 7 kb DNA fragment inserted, and the plasmid was named pEUPl.
  • Recombinant wild-type UPRTase was prepared as follows for crystal preparation for X-ray crystal structure analysis.
  • the reading frame of the upp gene encoding UPRTase (open reading frame) is assumed to start with Met-10, and Cys-160 is expected to be located on the molecular surface, causing aggregation when the purified enzyme is concentrated. This was replaced with Ser.
  • fusion PCR was performed using the following four types of primers, using the wild-type upp gene cloned in the plasmid pQE82L (Qiagen) as a cocoon.
  • PQE_C160S_Nl and pQE—C160S N2 having the base sequences represented by SEQ ID NOs: 3 and 4 and pQE—C160S one C1 and pQE_C160S_C2 having the base sequences represented by SEQ ID NOs: 3 and 3 and PCR was performed separately, and each product was purified by agarose electrophoresis. Subsequently, PCR was carried out by mixing them into a cage and using pQE_C160S_Nl and pQE_C160S-C2 as primers.
  • the amplified fragment is digested with the restriction enzyme BamHI and purified by agarose electrophoresis, and then digested with the restriction enzyme BamHI in advance and ligated with the plasmid pQE82L treated with alfa phosphatase.
  • Escherichia E. coli DH5 ⁇ strain was transformed.
  • the UPRTase having the amino acid sequence represented by SEQ ID NO: 38 was expressed as a fusion protein having a histidine tag at the amino terminal.
  • Escherichia coli BL21 was transformed with this plasmid, and the resulting transformant was used as the following UPRTase expression strain. Substitution of C160S had little effect on the specific activity of the enzyme (data not shown).
  • the suspension was resuspended in Na-phosphate pH 7.0, 300 IDM NaCl, 10 mM 2-mercaptoethanol, and the cells were disrupted by sonication while cooling in an ice bath. This was centrifuged at ⁇ lOOOOrpm for 1 hour to obtain a cell extract in the supernatant.
  • TAL0N resin manufactured by Clonetech
  • 200 juL of TAL0N resin was used per 50 mL of culture.
  • wash buffer 50 mM Na-phosphate pH 7.0, 15 mM imidazole, 10 mM 2-mercaptoethanol
  • elution buffer 50 mM Na-phosphate pH 7.0, 150 mM imidazole, 10 mM Elution with 2-mercaptoethanol.
  • the above operation was performed at room temperature. The following operations were performed at 4 ° C.
  • the collected fraction was dialyzed against the anion chromatography equilibration buffer (20 mM Tris-HCl, pH 8.5) for 1 ⁇ m. The dialyzed internal solution was centrifuged at lOOOO rpm for 10 minutes, and then only the supernatant fraction was collected.
  • Anion exchange capacity ram (monoQ column, GE Healthcare Pio Science) was added. After sufficiently equilibrating with the above buffer solution, elution was carried out with a linear concentration gradient of 0 ⁇ 0.5M NaCl using UV absorption at a wavelength of 280 nm as an index. The active fraction was dissolved in the range of 250 to 350 mM NaCl.
  • a stock solution was added to a concentration of 0.5 mM DTT and 0.5 mM GTP, and then concentrated using amicon ultra-15, and further concentrated buffer (20 mM Tris-HCl pH 8.5, 20 mM NaCl, 0.5 mM DTT, 0.5 mM GTP) was added, and the solution was concentrated to a concentration of 18 mg / mL while exchanging the original buffer.
  • Crystallization was performed by a sitting drop vapor diffusion method. By mixing equal amounts of the recombinant UPRTase concentrated solution prepared above and a solution containing 0.2 mM di-ammonium tartrate and 15-20% (w / v) PEG3350, and allowing to stand for about 1 week, Columnar crystals of about 0. 05 X 0. 05 X 0. 15 mm 3 were precipitated. [0 0 8 9]
  • X-ray diffraction data was collected using the ADSC Quantum 315 detector at the beamline BL5A of the Institute for Materials Structure Science, High Energy Accelerator Research Organization.
  • the wavelength was set to 1.0000 A and the distance from the crystal to the detector was set to 352.1 ⁇ 2 m.
  • the measurement temperature was 100K.
  • the exposure was performed for 20 seconds at a vibration angle of 1 ° per frame.
  • the value of Emerge is 10.8% at 100-2. 3 A resolution, and 2.4.1-2.30 A resolution at the outermost shell is 61.1. %.
  • the data integrity was 92.9% at 100-2.3A resolution and 89.6% at 2.42-2.30A resolution of the outermost shell.
  • the crystal asymmetric unit contained 4 UPRTase molecules, and the solvent content of the crystal was about 45%. [0 0 9 0]
  • the structure was determined by a molecular replacement method using the monomer structure of Thermotoga maritima UPRTase (PDB code 1050) as a search model.
  • the structural analysis program was MolRep (CCP package)
  • the structural refinement program was CNX (Accelrys)
  • the structural display program was Coot (CCP4 package).
  • CCP4 package After repetitive refinement, a 2.3 A resolution refined structure including water and GTP molecules was determined, and the Rf actor was 21.0% (Rfree 28.3%).
  • PR0CHECK When the Ramachandran plot was created using the program PR0CHECK, 90.6% of the non-glycine residues were located in the most preferred region, and 99.9% of the total residues were acceptable. It has been shown to have a dihedral angle of peptide bonds.
  • Table 1 shows the obtained three-dimensional structure information (structure coordinates).
  • ATOM 144 N MET A 27-30.104-21. 412 11., 178 1., 00 24. 38 N
  • ATOM 416 0 LYS A 60 -26. 322 -29. 132-29. 555 1. 00 53.41 0
  • ATOM 432 CA ILE A 63 -23. 539 37. 699 -28. 412 1. .00 49. 12 C
  • ATOM 438 0 ILE A 63 -25. 042 -39. 434-29. 117 1, .00 48. 64 0
  • ATOM 508 0 ILE A 72 -28. 343 -31. 491 -26.012 1, .00 41.33 0
  • ATOM 526 N ILE A 75 -24. 920-27.056 -20.304 1. 00 36.39 N
  • ATOM 705 0D1 ASN A 99-27.571 -26.781 -7.433 1.00 27.43 0
  • ATOM 752 0 ILE A 105 -11.830 -18.245 -9.648 1., 00 22.66 0

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Abstract

It is intended to provide a protein having an amino acid sequence represented by SEQ ID NO: 1, 2 or 30 having an activity to produce cytidine 5'-monophosphate (CMP) from cytosine, and a protein having an amino acid sequence in which in the amino acid sequence represented by SEQ ID NO: 1, 2 or 30, one or more amino acid residues selected from amino acid residues at positions 36, 46, 94, 102, 121, 141, 143, 167 and 198 have been substituted with another amino acid residue.

Description

明細書 シチジン 5， 一モノリン酸の製造法 技術分野  Description Method for producing cytidine 5, monomonophosphate Technical Field
【0001】  [0001]
本発明は、 シトシンからシチジン 5， 一モノリン酸 （CMP) を生成する活性を 有する新規蛋白質の製造方法、該蛋白質、該蛋白質をコードする DNA、該 DNA を含有する組換え体 DNA、該組換え体 DNAを保有する微生物、およぴ該微生物 の培養物などを用いた CMPの製造法に関する。  The present invention relates to a method for producing a novel protein having an activity of producing cytidine 5, monomonophosphate (CMP) from cytosine, the protein, a DNA encoding the protein, a recombinant DNA containing the DNA, the recombinant The present invention relates to a method for producing CMP using microorganisms that possess body DNA and cultures of the microorganisms.
背景技術 .  Background technology.
【0002】  [0002]
CMPは他のヌクレオチドであるアデノシン 5， 一モノリン酸 (AMP) 、 グァ ノシン 5， 一モノリン酸 (GMP) 、 ゥリジン 5， 一モノリン酸 (UMP) ととも に乳児用ミルクの添加物として用いられている。従来、 CMPは酵母 RNAの酵素 的分解法により製造されてきた （非特許文献 1) 。 しかしながら、 この RNA分角 法では 4種のヌクレオチドが同時に作られるため、生産量と需要量との差により生 産物に余剰がでる欠点がある。 このことから、安価な個別のヌクレオチドの製造法 の開発が望まれている。  CMP is used as an additive to infant milk with the other nucleotides adenosine 5, monomonophosphate (AMP), guanosine 5, monomonophosphate (GMP), uridine 5, monomonophosphate (UMP). Yes. Conventionally, CMP has been produced by enzymatic degradation of yeast RNA (Non-patent Document 1). However, this RNA dividing angle method has the disadvantage that four kinds of nucleotides are produced at the same time, resulting in a surplus in the product due to the difference between the production amount and the demand amount. For this reason, development of an inexpensive method for producing individual nucleotides is desired.
【0003】  [0003]
上記した 4種のヌクレオチドのうち、 GMPについては RNA分解法に代替しう る工業的な個別製法が確立されている （特許文献 1) 。 一方、 CMP， AMP, U MPについては安価な個別製法はまだ確立されていない。これらヌクレオチドの個 別製法としては、サルベージ合成経路を利用して、、化学合成法で製造した対応する 塩基を基質として用いる方法があり、 この経路を利用した具体例として、アデニン を基質としたアデノシン 5，一トリリン酸（ATP)の工業的製法があげられる（特 許文献 2) 。  Among the four types of nucleotides described above, an industrial individual production method has been established for GMP that can replace the RNA degradation method (Patent Document 1). On the other hand, inexpensive individual manufacturing methods for CMP, AMP, and UMP have not been established yet. As an individual method for producing these nucleotides, there is a method using a salvage synthesis route and using a corresponding base produced by a chemical synthesis method as a substrate. As a specific example using this route, adenosine using adenine as a substrate is used. 5. Industrial production of monotriphosphoric acid (ATP) is mentioned (Patent Document 2).
【0004】  0004
サルベージ合成経路に関与する酵素としては、ゥラシルとホスホリボシルピロリ ン酸（PRPP)から UMi5とピロリン酸を生成する反応を触媒するゥラシルホス ホリポシルトランスフェラーゼ （UPRTa s e) などの、塩基から対応するヌク レオチドを一段階で生産する酵素が知られている。 し力 しながら、 CMPを生成す るサルベージ合成経路の酵素は、 すべての生物種にわたって知られていない。 Enzymes involved in the salvage synthesis pathway include nucleotides corresponding to bases such as uracil phospholiposyltransferase (UPRTase), which catalyzes the reaction of UMi 5 and pyrophosphate from uracil and phosphoribosyl pyrophosphate (PRPP). Enzymes that produce succinamide in a single step are known. However, the salvage synthesis pathway enzymes that produce CMP are not known across all species.
【非特許文献 1】 J. Gen. Appl. Microbiol. , 3, 55 (1957)  [Non-Patent Document 1] J. Gen. Appl. Microbiol., 3, 55 (1957)
【特許文献 1】 特開昭 62-285797号公報 【特許文献 2】 特開平 2 - 13439 号公報 発明の開示 [Patent Document 1] Japanese Patent Laid-Open No. 62-285797 [Patent Document 2] Japanese Patent Laid-Open No. 2-13439 Disclosure of Invention
発明が解決しようとする課題  Problems to be solved by the invention
【0005】  [0005]
本発明の目的は、シトシンから CMPを生成する活性を有する新規蛋白質の製造 方法、 該蛋白質、 該蛋白質をコードする DNA、 該 DNAを含有する組換え体 DN A 該組換え体 DN Aを保有する微生物、および該微生物の培養物などを用いた C MPの製造法を提供することにある。 課題を解決するための手段  An object of the present invention is to provide a method for producing a novel protein having an activity of generating CMP from cytosine, the protein, a DNA encoding the protein, a recombinant DN A containing the DNA, and the recombinant DN A An object of the present invention is to provide a method for producing CMP using a microorganism and a culture of the microorganism. Means for solving the problem
【0006】  [0006]
本発明は以下の （1) 〜 （14) に関する。'  The present invention relates to the following (1) to (14). '
(1)シトシンからシチジン 5，一モノリン酸（CMP)を生成する活性を有する、 配列番号 1、 2、 または 30で表されるアミノ酸配列を有する蛋白—質。  (1) A protein having an amino acid sequence represented by SEQ ID NO: 1, 2, or 30, which has an activity of producing cytidine 5, monomonophosphate (CMP) from cytosine.
(2) 配列番号 1、 2、 または 30で表されるアミノ酸配列において、 36番目、 94番目、 102番目、 141番目、 143番目おょぴ 198番目のアミノ酸残基 から選ばれる 1以上のアミノ酸残基が他のアミノ酸残基に置換したアミノ酸配列 を有し、 かつシトシンから CMPを生成する活性を有する蛋白質。  (2) In the amino acid sequence represented by SEQ ID NO: 1, 2, or 30, one or more amino acid residues selected from the 36th, 94th, 102th, 141st, 143rd, 143rd, and 198th amino acid residues A protein having an amino acid sequence in which a group is substituted with another amino acid residue, and having an activity of generating CMP from cytosine.
(3) 36番目のアミノ酸残基がシスティン、 94番目のアミノ酸残基がチロシン、 102番目のアミノ酸残基がシスティン、 141番目のアミノ酸残基がロイシン、 143番目のアミノ酸残基がバリン、または 198番目のアミノ酸残基がグリシン に置換したアミノ酸配列を有する上記 （2) の蛋白質。  (3) 36th amino acid residue is cysteine, 94th amino acid residue is tyrosine, 102nd amino acid residue is cysteine, 141st amino acid residue is leucine, 143rd amino acid residue is valine, or 198 The protein according to (2) above, which has an amino acid sequence in which the second amino acid residue is substituted with glycine.
【0007】  [0007]
(4) 配列番号 1、 2、 または 30で表されるアミノ酸配列において、 36番目、 46番目、 94番目、 102番目、 121番目、 141番目、 143番目、 167 番目おょぴ 198番目のアミノ酸残基から選ばれる 1以上のアミノ酸残基が他の アミノ酸残基に置換したアミノ酸配列を有し、かつシトシンから CM Pを生成する 活性を有する蛋白質。  (4) In the amino acid sequence represented by SEQ ID NO: 1, 2, or 30, the 36th, 46th, 94th, 102nd, 121st, 141st, 143rd, 167th, 167th and 198th amino acid residues A protein having an amino acid sequence in which one or more amino acid residues selected from a group are substituted with other amino acid residues, and having an activity of generating CMP from cytosine.
(5)上記（1) ~ (4)のいずれかの蛋白質のアミノ酸配列において、 36番目、 94番目、 102番目、 1'41番目、 143番目、 198番目、 201番目、 20 4番目および 205番目以外のアミノ酸残基から選ばれる 1以上のアミノ酸残基 が他のアミノ酸残基に置換したァミノ酸配列を有し、かつシトシンから CMPを生 成する活性を有する蛋白質。  (5) 36th, 94th, 102th, 1'41st, 143rd, 198th, 201st, 20th, 204th and 205th in the amino acid sequence of the protein of any of the above (1) to (4) A protein having an amino acid sequence in which one or more amino acid residues selected from other amino acid residues are substituted with other amino acid residues, and having an activity of generating CMP from cytosine.
【0008】 (6)上記（1)〜（4)のいずれかの蛋白質のアミノ酸配列において、 36番目、 46番目、 94番目、 102番目、 121番目、 141番目、 143番目、 167 番目、 198番目、 201番目、 204番目おょぴ 205番目以外のアミノ酸残基 から選ばれる 1以上のァミノ酸残基が他のァミノ酸残基に置換したアミノ酸配列 を有し、 かつシトシンから CM Pを生成する活性を有する蛋白質。 [0008] (6) In the amino acid sequence of the protein of any of the above (1) to (4), 36th, 46th, 94th, 102th, 121st, 141st, 143rd, 167th, 198th, 201st , Has an amino acid sequence in which one or more amino acid residues selected from amino acid residues other than the 204th and 205th amino acids are substituted with other amino acid residues, and has an activity of generating CMP from cytosine protein.
(7) 以下の [1] または [2] に記載の DNA。  (7) The DNA according to [1] or [2] below.
[1] 上記 （1) 〜 （4) のいずれかの蛋白質をコードする DNA  [1] DNA encoding any of the proteins (1) to (4) above
[ 2 ] 配列番号 3〜 5のいずれかで表される塩基配列を有する D N A  [2] DNA having the base sequence represented by any of SEQ ID NOs: 3 to 5
(8) 上記 （7) の DNAを含む組換え体 DNA。  (8) A recombinant DNA comprising the DNA of (7) above.
【0009】  [0009]
(9) 上記 （8) の組換え体 DNAを保有する微生物。 . - (9) A microorganism having the recombinant DNA of (8) above. -
(10)微生物がエツシエリヒア属、 コリネバタテリゥム属またはブレビバタテリ ゥム属に属する微生物である、 上記 （9) の微生物。 ― (10) The microorganism according to (9) above, wherein the microorganism belongs to the genus Escherichia, the genus Corynebatarum, or the genus Brevibaterium. -
(11) 上記 （9) または （10) の微生物の培養物または該培養物の処理物、 シ トシン、 リン酸基供与体およびエネルギー供与体を水性媒体中に存在せしめ、該媒 体中に CMPを生成、蓄積させ、該媒体から CM Pを採取することを特徴とする C MPの製造法。  (11) The microorganism culture of (9) or (10) above or a treated product of the culture, cytosine, phosphate group donor and energy donor are present in an aqueous medium, and CMP is carried out in the medium. A process for producing CMP, characterized in that CMP is collected from the medium by generating and accumulating
【0010】  [0010]
(12) 上記 （9) または （10) の微生物の培養物または該培養物の処理物、 コ リネパクテリゥム属に属する微生物の培養物または該培養物の処理物、 シトシン、 リン酸基供与体およびエネルギー供与体を水性媒体中に存在せしめ、該媒体中に C MPを生成、蓄積させ、該媒体から CMPを採取することを特徴とする CMPの製 造法。 '  (12) The microorganism culture of (9) or (10) above or a treated product thereof, a culture of a microorganism belonging to the genus Corynepacteria or a treated product thereof, cytosine, a phosphate group donor and energy A process for producing CMP, comprising the step of causing a donor to be present in an aqueous medium, producing and accumulating CMP in the medium, and collecting CMP from the medium. '
(13) コリネバタテリゥム属に属する微生物がコリネパクテリゥム ·アンモニア ゲネスである、 上記 （12) の製造法。 、  (13) The process according to (12) above, wherein the microorganism belonging to the genus Corynebataterium is corynepacteria ammonia genes. ,
(14) 上記 （9) または （10) の微生物の培養物または該培養物の処理物、 シ トシン、 リン酸供与体おょぴエネルギー供与体を水性媒体中に存在せしめ、.該媒体 中に生成する CMPを用いることを特徴とする、 有用物質の製造法。  (14) The microorganism culture of (9) or (10) above or the treated product of the culture, cytosine, phosphate donor and energy donor are present in an aqueous medium, and A method for producing useful substances, characterized by using generated CMP.
【0011】  [0011]
本発明は、 また、 以下の （15) 〜 （24) に関する。  The present invention also relates to the following (15) to (24).
(15)  (15)
シトシンからシチジン 5， 一モノリン酸（CMP) を生成する活性を有する蛋白質 の製造方法であって、 下記工程を含む方法： A method for producing a protein having an activity of producing cytidine 5, monomonophosphate (CMP) from cytosine, comprising the following steps:
[1]ゥラシルからゥリジン 5， 一モノリン酸 (UMP) を生成する活性を有する蛋 白質（UPRTa s e) の三次元構造情報の一部又は全体を用いてコンピュータ上 で UPRTa s eにおける UMP結合部位に CMPを適合させて作成される UP RT a s eと CMPとの複合体モデルを安定化させる、 U P R T a s eのアミノ酸 配列におけるァミノ酸の欠失、 置換及び /又は付加を 1個以上選択する工程； [2]工程 [1]で選択された欠失、置換及び/又は付加を含む UP RT a s eの変異 蛋白質を製造する工程。 [1] CMP on the UMP binding site in UPRTa se on a computer using part or all of the three-dimensional structural information of protein (UPRTa se) that has the activity of generating uridine 5, monomonophosphate (UMP) from uracil Created by adapting UP Select one or more amino acid deletions, substitutions and / or additions in the amino acid sequence of UPRT ase that stabilizes the complex model of RTase and CMP; [2] selected in step [1] A process for producing a UPRTase mutant protein containing a deletion, substitution and / or addition.
【0012】  [0012]
(16)  (16)
シトシンからシチジン 5， 一モノリン酸（CMP) を生成する活性を有する蛋白質 の製造方法であって、 下記工程を含む方法： A method for producing a protein having an activity of producing cytidine 5, monomonophosphate (CMP) from cytosine, comprising the following steps:
[11]ゥラシルからゥリジン 5， 一モノリン酸 (UMP) を生成する活性を有する 蛋白質（UPRTa s e)の三次元構造情報の一部又は全体を用いてコンピュータ 上で UPRTa s eにおける UMP結合部位に CMPを適合させて作成される U PRTa s eと CMPとの複合体モデルを安定化させる、 U P R T a s eのァミノ 酸配列におけるアミノ酸の 失、 置換及び/叉は付加を 1個.以上選択する工程；.  [11] Using a part or all of the three-dimensional structure information of the protein (UPRTase) that has the activity to generate uridine 5, monomonophosphate (UMP) from uracil, CMP is applied to the UMP binding site in UPRTase on a computer. Select one or more amino acid deletions, substitutions and / or additions in the amino acid sequence of UPRTase, which stabilizes the UPRTase and CMP complex model created by adaptation;
[12]前記複合体モデルの一部又は全体を用いてコンピュータ上で作成される該 複合体の多量体モデルを安定化させる、 UPRTa s eのアミノ酸配列におけるァ ミノ酸の欠失、 置換及び/又は付加を 1個以上選択する工程； [12] Amino acid deletion, substitution and / or in the amino acid sequence of UPRTase, which stabilizes a multimer model of the complex created on a computer using a part or all of the complex model Selecting one or more additions;
[13]工程 [11]および [12]で選択された欠失、置換及び/又は付加を含む UP RTa s eの変異蛋白質を製造する工程。 [13] A step of producing a UP RTase mutant protein comprising the deletion, substitution and / or addition selected in the steps [11] and [12].
(17)  (17)
(15) 又は （16) に記載の方法により得られる蛋白質。  (15) A protein obtained by the method according to (16).
【0013】  [0013]
(18)  (18)
配列番号 15に記載のァミノ酸配列において、 Γ乃至数個のァミノ酸が欠失、置換 及び Z又は付加されているアミノ酸配列を有し、 In the amino acid sequence shown in SEQ ID NO: 15, the amino acid sequence has Γ to several amino acids deleted, substituted and Z or added,
シトシンから CMPを生成する活性を有し、 かつ、 ' 下記アミノ酸置換を 1個以上含む蛋白質： A protein that has the activity of generating CMP from cytosine and contains one or more of the following amino acid substitutions:
表 1に記載の三次元座標原子座標であらわされる配列番号 15に記載のアミノ酸 配列からなりかつゥラシルから UM Pを生成する活性を有する蛋白質（UPRTa s e)の三次元構造情報の一部又は全体を用いてコンピュータ上で作成される UP RT a s eと UMPとの複合体モデルにおいて、 UMPのピリミジン環 4位のォキ ソ基の酸素原子から 10 Aの翁囲に構成原子が存在するアミノ酸の置換であって、 前記複合体モデルの UMPのォキソ基をァミノ基に変換することによりコンビュ ータ上で作成される UP RT a s eと CMPとの複合体モデルを安定化させるァ ミノ酸への置換。 Part or all of the three-dimensional structural information of a protein (UPRTase) comprising the amino acid sequence of SEQ ID NO: 15 represented by the three-dimensional coordinate atomic coordinates described in Table 1 and having an activity of generating UMP from uracil. In a complex model of UP RT ase and UMP that is created on a computer using UMP, substitution of an amino acid with a constituent atom in the range of 10 A from the oxygen atom of the oxo group at the 4-position of the pyrimidine ring of UMP Then, substitution of amino acid that stabilizes the complex model of UP RTase and CMP created on the converter by converting the UMP group of UMP of the complex model into an amino group.
(19)  (19)
4 j 前記のァミノ酸置換が配列番号 15に記载のァミノ酸配列の 205位のダリシン の置換である （18) に記載の蛋白質。 4 j The protein according to (18), wherein the amino acid substitution is substitution of dalysin at position 205 in the amino acid sequence described in SEQ ID NO: 15.
【0014】  [0014]
(20)  (20)
前記のァミノ酸置換が配列番号 15に記載のァミノ酸配列の 205位のグリシン のァスパラギン酸又はグルタミン酸への置換である （18) に記載の蛋白質。 (21) The protein according to (18), wherein the amino acid substitution is substitution of glycine at position 205 to aspartic acid or glutamic acid in the amino acid sequence represented by SEQ ID NO: 15. (twenty one)
前記のァミノ酸置換が配列番号 15に記载のァミノ酸配列の 201位のチロシン 及び 204位のプロリンの置換である （18) に記載の蛋白質。 The protein according to (18), wherein the amino acid substitution is substitution of tyrosine at position 201 and proline at position 204 of the amino acid sequence described in SEQ ID NO: 15.
(22)  (twenty two)
前記のァミノ酸置換が配列番号 15に記載のァミノ酸配列の 201位のチロシン のリジンへの置換及ぴ 204位のプロリンのロイシンへの置換である （18) に記 載の蛋白質。'.. ― The protein according to (18), wherein the amino acid substitution is substitution of tyrosine at position 201 to lysine and substitution of proline at position 204 to leucine in the amino acid sequence shown in SEQ ID NO: 15. '.. ―
(23)  (twenty three)
前記の UPRTa s eと UMPとの複合体モデルにおいて UMPを橇成するいず れかの原子から 1 OAの範囲に構成原子が存在するアミノ酸の置換（ただし UMP のピリミジン環 4位のォキソ基の酸素原子から 1 OAの範囲に構成原子が存在す るアミノ酸の置換を除く）であって、前記の UPRTa s eと CMPとの複合体モ デルを安定化させるアミノ酸への置換を 1個以上含む （18) 〜 （22) のいずれ か一項に記載の蛋白質。 In the above complex model of UPRTase and UMP, substitution of an amino acid having a constituent atom in the range of 1 OA to any atom that forms UMP (however, oxygen of the oxo group at the 4-position of the pyrimidine ring of UMP) Including one or more amino acid substitutions that stabilize the complex model of UPRTase and CMP as described above (except for substitutions of amino acids whose constituent atoms are in the range from 1 atom to 1 OA) (18 ) The protein according to any one of (22) to (22).
【0015】  [0015]
(24)  (twenty four)
表 1に記載の三次元座標原子座標であらわされる配列番号 15に記载のァミノ酸 配列からなりかつゥラシルから UMPを生成する活性を有する蛋白質（UPRTa s e)の三次元構造情報の一部又は全体を用いてユンピュータ上で作成'される UP RT a s eとホスホリボシルピロリン酸（PRP P) との複合体モデルにおいて P RP Pを構成するいずれかの原子から 10 Aの範囲に構成原子が存在するアミノ 酸の置換であって、該複合体モデルを安定化させるアミノ酸への置換を 1個以上含 む （18) 〜 （22) のいずれか一項に記載の蛋白質。 Part or all of the three-dimensional structural information of the protein (UPRTase) comprising the amino acid sequence described in SEQ ID NO: 15 represented by the three-dimensional coordinate atomic coordinates shown in Table 1 and having the activity of generating UMP from uracil In a complex model of UP RTase and phosphoribosyl pyrophosphate (PRP P) created on a computer with Y (18) The protein according to any one of (18) to (22), which is an acid substitution and includes at least one amino acid substitution that stabilizes the complex model.
(25)  (twenty five)
前記の UPRTa s eと CMPとの複合体モデルの一部又は全体を用いてコンビ ユータ上で作成される複合体の多量体モデルにおいて、隣接する UPRTa s e単 量体のいずれかの原子から 5 A以内に構成原子が存在するアミノ酸 及び隣接す る UPRTa s e単量体の 66位 Trpのいずれかの構成原子から 5 A以内に構成原 子が存在するアミノ酸からなる群から選択されるアミノ酸の置換であって、該多量 体モデルを安定化させるアミノ酸への置換 を 1個以上含む （18) 〜 （24) のいずれか一項に記載の蛋白質。 Within a complex multimer model created on a computer using a part or all of the complex model of UPRTa se and CMP, within 5 A from any atom of the adjacent UPRTa se monomer A substitution of an amino acid selected from the group consisting of an amino acid having a constituent atom and an amino acid having a constituent atom within 5 A from any one of the constituent atoms of position 66 Trp of the adjacent UPRTase monomer. Substitution with amino acids that stabilize the multimeric model (18) The protein according to any one of (18) to (24), which contains one or more.
本努明はさらに、上記いずれかの CP RT a s eの製造方法により得られる蛋白 質；該蛋白質をコードする DNA；該 DNAを含む組換え体 DNA；該耝換え体 D N Aを保有する微生物；該微生物を用いた CMPおよび CMPを基質としてまたは CMPを経由して生産される有用物質の製造法に関する。 図面の簡単な説明  The present invention further includes a protein obtained by any one of the above-mentioned CP RTase production methods; a DNA encoding the protein; a recombinant DNA containing the DNA; a microorganism having the recombinant DNA; The present invention relates to a process for producing useful substances produced using CMP and CMP as a substrate or via CMP. Brief Description of Drawings
【0016】  0016
【図 1】各種 UPRTa s eのアミノ酸配列のアラインメント結果を示す図である。 【図 2】 G205D、 M141L、 A143Vのアミノ酸置換を有する変異型 Escherichia coli FIG. 1 is a diagram showing the alignment results of amino acid sequences of various UPRTases. Fig. 2 Mutant Escherichia coli with amino acid substitutions of G205D, M141L, and A143V
UPRTaseと CMPとの複合体モデルを示す図である。 It is a figure which shows the composite model of UPRTase and CMP.
【図 3】 Escherichia coli UPRTaseと CMPとの複合体の四量体のモデルを示す図 である。 - ― ' 発明を実施するための最良の形態 '  FIG. 3 is a diagram showing a tetramer model of a complex of Escherichia coli UPRTase and CMP. -― 'Best Mode for Carrying Out the Invention'
【0017】  [0017]
本発明のシトシンからシチジン 5， 一モノリン酸（CMP) を生成する活性を有 する蛋白質 （CPRTa s e) は、 ゥラシルからゥリジン 5' —モノリン酸 （UM P) を生成する活性を有する蛋白質（UPRTa s e) の衮異蛋白質として得るこ とができる。 UPRTa s eの変異蛋白質とは UP RT a s eのアミノ酸配列にお いて 1乃至数個のアミノ酸が欠失、置換及び/又は付加されているアミノ酸配列を 有する蛋白質を有する。 なお、数個とは、 30個であればよく、 20個であること が好ましく、 5個であることがより好ましい。 '  The protein (CPRTa se) having the activity of producing cytidine 5, monomonophosphate (CMP) from cytosine of the present invention is the protein (UPRTa se) having the activity of producing uridine 5′-monophosphate (UM P) from uracil. ) Can be obtained as a different protein. The UPRTase mutated protein is a protein having an amino acid sequence in which one to several amino acids have been deleted, substituted and / or added in the amino acid sequence of UPRTase. In addition, the number of pieces may be 30 pieces, preferably 20 pieces, and more preferably 5. '
【0018】  [0018]
本明細書において、 シトシンからシチジン 5， モノリン酸 （CMP) を生成す る活性 （CPRTa s e活性） とは、 シトシンと P R P Pとから CMPとピロリン 酸を合成する活性を意味する。本明細書において、 CPRTa s eはゥラシルと P 1 ??から11^^?を合成する活性（UPRTa s e活性） を同時に有していてもよ いが、後述の実施例で行う方法などにより確認できる方法で比較した場合に、 C P RT a s e活性が UPRT a s e活性よりも高いことが好ましく、 CPRTa s e 活性が UPRTa s e活性よりも 10倍高いことがより好ましく、 U P R T a s e 活性を実質的に有しないことがさらに好ましい。  In the present specification, the activity of generating cytidine 5, monophosphate (CMP) from cytosine (CPRTase activity) means the activity of synthesizing CMP and pyrophosphoric acid from cytosine and PRPP. In this specification, CPRTa se may have the activity of synthesizing 11 ^^? From uracil and P 1 ?? (UPRTa se activity), but it can be confirmed by the method described in the examples below. When compared by the method, it is preferable that the CPRTase activity is higher than the UPRTase activity, the CPRTase activity is more preferably 10 times higher than the UPRTase activity, and it has substantially no UPRTase activity. Further preferred.
【0019】  [0019]
CPRTa s eの製造のための、 UPRT a s eに加えるアミノ酸変異の選択は、 ランダムに変異蛋白質を作成し、後述の方法によりそれらの変異蛋白質の活性を確 認してスクリーニングを行うことが可能である。アミノ酸変異又は変異とは、 UP RT a s eのアミノ酸配列に加える、アミノ酸の欠失、置換及び/又は付加を意味 する。 Selection of amino acid mutations to be added to UPRTase for the production of CPRTase can be carried out by preparing mutant proteins at random and confirming the activity of those mutant proteins by the method described below. Amino acid mutation or mutation is UP Means amino acid deletion, substitution and / or addition in addition to the RTase amino acid sequence.
スクリーユング方法は、特に限定されないが、例としては、任意の変異を有する 蛋白質をコードする DNAを含む組換え体 DNAを用いて、 Py rG (CTPシン セターゼ） 、 c o dA (シトシンデアミ^ "一ゼ） 、 c d d (シチジンデァミナーゼ） の 3つの酵素活性を喪失しているエツシエリヒア'コリを形質転換し、得られた形 質転換体が、シトシン含有最少培地中で生育するか否かを指標に行う方法をあげる ことができる。 また、任意の変異を有する蛋白質を製造し、生成する CMP量を定 量し、 CPRTa s e活性を確認することによって行ってもよレヽ。  Although the screening method is not particularly limited, for example, Py rG (CTP synthetase), co dA (cytosine deamidation) using a recombinant DNA containing a DNA encoding a protein having an arbitrary mutation. ), Cdd (Cytidine deaminase) E. coli which has lost the three enzyme activities transformed, and whether the resulting transformant grows in a cytosine-containing minimal medium as an indicator Alternatively, it may be carried out by producing a protein having an arbitrary mutation, quantifying the amount of CMP produced, and confirming CPRTase activity.
【0020】  [0020]
また、 CPRTa s eの製造のために UPRT a s eに加えるアミノ酸変異の選 択の別の方法としては、 UP RT a s eの三次元構造情報に基づいて作成されるコ ンピューター上のモデルを利用した方法を挙げることができる。  Another method for selecting amino acid mutations to be added to UPRTase for the production of CPRTase is to use a computer model created on the basis of the three-dimensional structure information of UPRTase. Can be mentioned.
【0021】  [0021]
UPRTa s eの三次元構造情報としては、当業者が入手可能ないずれの情報を 用いてもよく、結晶構造解析により得られた構造又は PDB(Protein Data Bank) 等 のデータベースから取得できる構造情報を用いてもよいし、該構造を铸型として I nsight 97等の蛋白質ホモロジ一モデル作成プログラムを用いて作成される構造 情報を用いてもよい。 また、三次元構造情報は UPRTa s. e単量体の情報であつ てもよく、二量体または四量体などの多量体の情報であってもよい。 さらに、三次 元構造情報は UPRTa s e単量体又は多量体の一部に関するものであってもよ いが、後述の UMP結合部位の情報を含んでいることが好ましい。 また、 多量体モ デルの作成に上記三次元情報が用いられる際には単量体同士の境界部分の情報を 含むことが好ましい。  As the three-dimensional structure information of UPRTase, any information available to those skilled in the art may be used. Structure information obtained by crystal structure analysis or structure information obtained from a database such as PDB (Protein Data Bank) is used. Alternatively, the structure information created by using a protein homology model creation program such as Insight 97 with the structure as a saddle may be used. Further, the three-dimensional structure information may be information on UPRTase monomer, and may be information on a multimer such as a dimer or a tetramer. Furthermore, the three-dimensional structure information may relate to a part of the UPRTase monomer or multimer, but preferably includes information on the UMP binding site described below. In addition, when the above three-dimensional information is used to create a multimeric model, it is preferable to include information on the boundary between monomers.
【0022】 、  ,
UPRTa s eに加えるアミノ酸変異の選択のために、例えば、上記の UPRT a s eの三次元構造情報を用いて UPRT a s eと CMPとの複合体モデ^を作 成することができる。 このモデルの作成には、三次元構造情報の全体を用いてもよ く、一部を用いてもよい。一部を用いる場合は少なくとも後述の UMP結合部位を 含む部位を選択することが好ましい。 また、 UPRTa s eと CMPとの複合体の 安定化に関与すると考えられる部位を予め選択し、該部位を含む複合体モデルを作 成してもよい。  In order to select amino acid mutations to be added to UPRTase, for example, a composite model of UPRTase and CMP can be created using the above-described three-dimensional structural information of UPRTase. In creating this model, the entire 3D structure information or a part of it may be used. When using a part, it is preferable to select a site containing at least the UMP binding site described later. Alternatively, a site considered to be involved in stabilization of the complex of UPRTase and CMP may be selected in advance, and a complex model including the site may be created.
【0023】  [0023]
三次元構造情報を用い、かつ変異の基となる UPRTa s eとしては、 ゥラシノレか らゥリジン 5' —モノリン酸（UMP) を生成する活性を有する蛋白質であればよ く、 由来する生物については特に限定されない。 由来する微生物の例としては、 Acholeplasma laidlawii (J Bacteriol. (1983)156:192-7 Crithidia luciliae (Comp Biochem Physiol B. (1990) 95 :159-63. ) Escherichia coli (Biochim Biophys Acta. (1986) 881 268-75. Genbank Accession No. X57104) Bacillus caldolyticus (J Bacteriol. (1994) 176 :3698 - 707. Genbank Accession No. X99545) Toxoplasma gondii (Proc Natl Acad Sci USA. (1995)92:5749-53· Genbank Accession No. U10246) Sulfolobus shibatae (Biochim Biophys Acta. (1996) 1296 :16 - 22.) を挙げることができる。 UPRTase, which uses three-dimensional structural information and is the basis for mutation, may be any protein that has the activity to produce uridine 5'-monophosphate (UMP) from uracinole, and the organism from which it is derived is particularly limited. Not. Examples of derived microorganisms include Acholeplasma laidlawii (J Bacteriol. (1983) 156: 192-7 Crithidia luciliae (Comp Biochem Physiol B. (1990) 95: 159-63.) Escherichia coli (Biochim Biophys Acta. (1986) 881 268-75.Genbank Accession No X57104) Bacillus caldolyticus (J Bacteriol. (1994) 176: 3698-707.Genbank Accession No.X99545) Toxoplasma gondii (Proc Natl Acad Sci USA. (1995) 92: 5749-53 · Genbank Accession No. (Biochim Biophys Acta. (1996) 1296: 16-22).
【0024】  [0024]
UPRT a s eにおける UMP結合部位については、 Toxoplasma gondii由来の UPRT a s eについて既に報告されている （EMB0 J. (1998)17 3219-3232) 。 こ の、 Toxoplasma gondii由来の UPRT a s eにおいては、 236番目のフエ-ル ァラニンのアミ ド水素原子においてピリミジン環 2位のカルボニル基酸素原子と、 234番目のグリシンのカルボニル基の酸素原子においてピリミジン環 3位の水 - 素原子と、 また 22 9番目のイソロイシンのアミ ド水素 原子においてピリミジン 環 4位のカルボニル基酸素原子と水素結合を形成することにより、 UMPのピリミジ ン環との結合を安定化させている。  Regarding the UMP binding site in UPRT a s e, UPRT a s e derived from Toxoplasma gondii has already been reported (EMB0 J. (1998) 17 3219-3232). In this UPRTase derived from Toxoplasma gondii, the carbonyl oxygen atom at the 2-position of the pyrimidine ring on the amide hydrogen atom of the 236th phalaranine and the pyrimidine ring 3 at the oxygen atom of the carbonyl group of the 234th glycine. The hydrogen bond with the hydrogen atom at the position and the amide hydrogen atom of the 22nd 9th isoleucine form a hydrogen bond with the oxygen atom at the 4-position of the pyrimidine ring, thereby stabilizing the bond with the pyrimidine ring of UMP. ing.
【0025】  [0025]
上記文献に記載の UM P結合部位に関する情報をもとに他の種の U PRT a s eについても、 UMP結合部位を決定することができる。 具体的には、 Toxoplasm a gondii由来の UPRT a s eのアミノ酸配列と、 三次元構造情報を用いる U P RT a s eのアミノ酸配列のアラインメントを行って （ClustalW[Nucelic Acids Research 22, 4673, (1994)] ( European Bioinformatics Instituteのウェブサ ィト http: . ebi. ac. uk/clustalwより利用することができる）、 遺伝子解析ソ ブトウェア Genetyx (ソフトウェア開発株式会社） に含まれるァライメント解析ソ フト）三次元構造情報における UMP結合部位を決定することができる。 ァライメ ントを行う際の解析ソフトのパラメーターとしては、デフォルト値を用いることが できる。 Toxoplasma gondii, Escherichia coli由来の UPRT a s eを含む各種 UPRTa s eのアミノ酸配列のアラインメントを行った例を図 1に示す。この結 果から EschericMa coli由来の UPRT a s eにおいては、 202位のイソロイ シン、 20 7位のグリシン、 20 9位のァラニン等が、 UMPのピリミジン環の結 合に関与すると考えられる。  Based on the information on the UMP binding site described in the above document, the UMP binding site can also be determined for other types of UPRT as. Specifically, alignment of the amino acid sequence of UPRT ase derived from Toxoplasma gondii and the amino acid sequence of UPRT ase using three-dimensional structural information (ClustalW [Nucelic Acids Research 22, 4673, (1994)] (European Bioinformatics Institute website (http:. Ebi. Ac. Uk / clustalw), alignment analysis software included in Genetyx (Software Development Co., Ltd.) 3D structure information UMP binding The site can be determined. Default values can be used as analysis software parameters for alignment. FIG. 1 shows an example of alignment of amino acid sequences of various UPRTases including UPRT ase derived from Toxoplasma gondii and Escherichia coli. From this result, in UPRT ase derived from EschericMa coli, isoleucine at position 202, glycine at position 107, alanine at position 209, etc. are considered to be involved in the binding of the pyrimidine ring of UMP.
【0026】  [0026]
UPRT a s eと CMPとの複合体モデルの作成のために、上記の UMP結合部 位に、 コンピュータ上で CMPを適合させることができる。  In order to create a composite model of UPRT as and CMP, CMP can be adapted on the computer to the above UMP coupling site.
UMP結合部位に CMPを適合させる方法としては、例えば、以下の方法が挙げ られる。 Escherichia coli 由来の UPRT a s eに UMPをドッキングさせ、 To xoplasma gondii由来の U P R T a s eに関してすでに報告されている、 UMPの ピリミジン環と WPRTa s eの水素結合が保たれている配座をとっている構造 を選択後、複合体に対しエネルギー極小化させて作成した UMP複合体モデルを用 いる。上記複合体モデルにおける UM Pのピリミジン環 4位カルボニル基の酸素を ァミノ基に置換して、 ピリミジン環 3位の水素を削除することによって、 CMPと して、 UMPを CMPに変換する。 さらに、該モデルについて再ぴエネルギー極小 化計算を行う。 Examples of methods for adapting CMP to the UMP binding site include the following methods. Dock UMP to UPRT ase from Escherichia coli After selecting the structure that has already been reported for UPRTase derived from xoplasma gondii and adopting the conformation in which the hydrogen bond of UMP pyrimidine ring and WPRTase is maintained, it was created by minimizing the energy of the complex. The UMP complex model is used. In the above complex model, oxygen in the 4-position carbonyl group of the pyrimidine ring of UMP is substituted with an amino group, and hydrogen at the 3-position of the pyrimidine ring is removed, so that UMP is converted to CMP as CMP. Further, repeat energy minimization calculation is performed for the model.
このように UMP結合部位に CMPを適合させて UPRT a s eと CMPとの 複合体モデルを作成することができる。  Thus, a complex model of UPRT as and CMP can be created by adapting CMP to the UMP binding site.
【0027】  [0027]
上述のように作成した U PRT a s eと CMPとの複合体モデルを利用した、 C PRT a s e製造のための UPRT a s eのアミノ酸変異の選択は、該モデルを安 定化させる UP RT a s eのアミノ酸変異の選択をすることにより行えばよレ.、。 本明細書において、 「モデルを安定化させる」 とは、 例えば Δ AGを下げること を意味する。 ここで、 AG (フリーエネルギー変化) は、 UPRTaseと UMPの複合体 のエネルギーから、蛋白質単体のエネ ギーと UMP単体のエネルギーを差し引いた ものを意味し、 AAGは、 ここでは UPRTaseと CMPの複合体構造から算出される Δ G力 ら、 変異型 UPRTaseと CMPの複合体構造から算出される AGを引いたものを意 味する。例えば、モデルを安定化させるアミノ酸置換等の変異の選択は、 コンビュ ータ上で、 変異前と変異後のモデルの AGの差異を算出し、 アミノ酸変異後ェネル ギーレベルが、 5k J /mo 1、 好ましくは 20 k J /mo 1、 さらに好ましくは 5 0k J/mo 1以上の低下する変異を選択することにより行うことができる。 この ような計算はドッキングプログラム Glide などで行うことができる。  The selection of amino acid mutations in UPRTase for the production of C PRTase using the complex model of U PRTase and CMP created as described above is the selection of amino acid mutations in UPRTase that stabilize the model. You can do it by making a choice. In this specification, “stabilizing the model” means, for example, reducing ΔAG. Here AG (free energy change) means the energy of the complex of UPRTase and UMP minus the energy of the protein alone and the energy of UMP alone. AAG is the complex of UPRTase and CMP here. It means the ΔG force calculated from the structure minus the AG calculated from the complex structure of mutant UPRTase and CMP. For example, when selecting mutations such as amino acid substitutions that stabilize the model, the AG difference between the model before and after the mutation is calculated on the converter, and the energy level after the amino acid mutation is 5 kJ / mo 1, It can be carried out by selecting a mutation that preferably decreases by 20 kJ / mo 1, more preferably 50 kJ / mo 1 or more. Such calculations can be performed with the docking program Glide.
【0028】  [0028]
また、モデルを安定化させるアミノ酸置換等の変異の選択は、モデルの構成要素 間（UPRT a s eと CMPとの複合体モデルにおける U P R T a s eと CMPと の間、又は多量体モデルにおける単量体間など） の親和性を指標に行うことができ る。 すなわち、 構成要素間の親和性を上昇させる変異を選択すればよい。  In addition, mutations such as amino acid substitutions that stabilize the model can be selected between model components (such as between UPRT ase and CMP in a complex model of UPRT ase and CMP, or between monomers in a multimeric model). ) Can be used as an index. That is, a mutation that increases the affinity between components may be selected.
【0029】  [0029]
' 親和性を上昇させる変異の選択は、例えばモデルの目視による観察で行うことが できる。 モデルにおける構^要素間 （UPRT a s eと CMP、 単量体間など） の 疎水相互作用、 ·静電相互作用 ·水素結合 · π/π相互作用 （芳香環の環電流が発 生する磁場同士の相互作用） 'CH/π相互作用 （芳香環の環電流とメチル基の電子 が発生する磁場の相互作用） 1 増加、 又は増強する変異を選択すればよい。 【0030】 UPRT a s eと CMPとの複合体モデルにおいて、具体的には、モデルの安定 化のためにまず、 UMPと CM Pの構造上の差異に着目して変異を選択することが できる。 UMPと CMPはピリミジン環 4位につき、 UMPはォキソ基、 CMPは アミノ基である点が異なっている。従って例えば、 CMPのピリミジン環 4位アミ ノ基の近傍（ァミノ基の窒素原子の中心から 1 OA程度好ましくは 8 A程度、 より 好ましくは 5 A程度）に構成原子の中心が存在する UPRTa s eのァミノ酸残基 を CMPのァミノ基と親和的に相互作用するァミノ酸残基に変更することにより UPRT a s eと CMPとの間の親和性を上昇させうる。なお、本明細書において、 原子間の距離を示す場合は原子の中心同士の距離を示す。原子間の距離は Insight 97によりグラフィックス上に表示させたモデルにおいて、 測定したい 2つの原子 同士をタリックし選択することにより測定することができる。 また、 UMPと CM Pはピリミジン環 3位の窒素原子が水素原子を有するか否かにおいて異なってい る。 従って、例えば、 CMPのピリミジン環 3·位の窒素原子の近傍 （該窒素原子の 中心から 10 A程度好ましくは 8 A程度、 より好ましくは 5 A程度） に構成原子の 中心が存在する UPRT a s eのアミノ酸残基を CMPのァミノ基と親和的に相 互作用するアミノ酸残基に変更することにより UPRT a s eと CMPとの間の 親和性を上昇させうる。 さらに、上記のピリミジン環 4位及ぴ 3位の近傍の UP R T a s eのアミノ酸残基を総合的に判断して変異を選択することも好ましい。これ は、 UMPと CMPではピリミジン環 2位、 3位の水素結合のドナー、 ァクセプタ 一の関係が逆になると考えることができるためなどによる。 'Selection of mutations that increase affinity can be done, for example, by visual observation of the model. Hydrophobic interaction between structural elements (UPRT ase and CMP, between monomers, etc.) in the model, · electrostatic interaction · hydrogen bonding · π / π interaction (magnetic field generated by ring current of aromatic ring) Interaction) 'CH / π interaction (Interaction of the ring current of the aromatic ring and the magnetic field generated by the electrons of the methyl group) 1 Select a mutation that increases or enhances. [0030] In the complex model of UPRTase and CMP, specifically, in order to stabilize the model, mutations can be selected first by focusing on the structural differences between UMP and CMP. UMP and CMP differ at the 4-position of the pyrimidine ring, except that UMP is an oxo group and CMP is an amino group. Therefore, for example, in the UPRTase where the center of the constituent atom exists in the vicinity of the 4-position amino group of the pyrimidine ring of CMP (about 1 OA, preferably about 8 A, more preferably about 5 A from the center of the nitrogen atom of the amino group). Affinity between UPRTase and CMP can be increased by changing the amino acid residue to an amino acid residue that interacts with the CMP amino group. In addition, in this specification, when showing the distance between atoms, the distance between the centers of atoms is shown. The distance between atoms can be measured by tapping and selecting two atoms to be measured in the model displayed on graphics by Insight 97. UMP and CMP differ in whether the nitrogen atom at the 3-position of the pyrimidine ring has a hydrogen atom. Thus, for example, the UPRT ase in which the center of the constituent atom exists in the vicinity of the nitrogen atom at the 3-position of the pyrimidine ring of CMP (about 10 A, preferably about 8 A, more preferably about 5 A from the center of the nitrogen atom). Affinity between UPRTase and CMP can be increased by changing the amino acid residue to an amino acid residue that interacts with the CMP amino group. Furthermore, it is also preferable to select a mutation by comprehensively judging the amino acid residues of UPRTase in the vicinity of the 4th and 3rd positions of the pyrimidine ring. This is because, in UMP and CMP, it can be considered that the relationship between the 2- and 3-position hydrogen bond donors and acceptors of the pyrimidine ring is reversed.
このような UMPと CM Pの構造上の差異に着目して選択される変異は UP R T a s eと CMPとの複合体モデルの安定化に最も寄与しやすく、 UPRT a s e の活性変化の要になる変異であると考えられる。 '  Mutations selected by focusing on the structural differences between UMP and CMP are most likely to contribute to the stabilization of the complex model of UPRTase and CMP, and are essential for the change in UPRTase activity. It is thought that. '
【0031】  [0031]
例えば、 Escherichia coli UPRTaseでは 205位 Glyを例えば Asp又は Glu、 に することによって、 この Asp又は Glu残基と、シトシンのアミノ基との間に静電的 相互作用が生じ、 複合体モデ^/を安定化しうる。 また、 201位 Tyrを Lysとするこ とによって、結合部位の形状が、 ピリミジン環が結合しうるのに適した、 平らな形 状となり、 複合体モデ^^を安定化しうる。 なお、 本明細書において、 例えば 205 位 Glyを Aspに置換することは G20SDとするように、変異位置を示す数値の前に変 異前のァミノ酸、 後に変異後のァミノ酸を 1文字略号を用いて示すことがある。 【0032】  For example, in Escherichia coli UPRTase, by making Gly at position 205, for example, Asp or Glu, an electrostatic interaction occurs between this Asp or Glu residue and the amino group of cytosine. Can be stabilized. In addition, by using Lys as the 201 position Tyr, the shape of the binding site becomes a flat shape suitable for the binding of the pyrimidine ring, and the complex model can be stabilized. In this specification, for example, replacing Gly at position 205 with Asp is G20SD, so that the amino acid before the mutation is preceded by the numerical value indicating the mutation position, and then the amino acid after the mutation is abbreviated by one letter. May be used to indicate. [0032]
UPRT a s eと CMPとの複合体モデルを安定化させる変異の選択のために、 UPRT a s eと UMPとの複合体モデルを用いることもできる。 UMPと CMP の結合位置はほぼ同じであると考えられるため、上記の三次元構造情報から直接的 に作成される UMPと UPRT a s eとの複合体モデルを用いることで、実質的に CMPと UPRTa s e相互作用に関与するアミノ酸を選択することができるか らである。 このモデルにおいて、例えば、 UMPのピリミジン環 4位ォキソ基の近 傍のアミノ酸残基（ォキソ基の酸素原子の中心から 10 A程度好ましくは 8 A程度、 より好ましくは 5 A程度に構成原子の中心が存在するァミノ酸残基）を選択するこ とができる。変異後のアミノ酸は、 ピリミジン環 4位ォキソ基がアミノ基におきか わることを想定して選択すればよい。 また、 UMPのピリミジン環 3位窒素原子の 近傍のアミノ酸残基（該窒素原子の中心から 10 A程度好ましくは 8 A程度、 より 好ましくは 5 A程度に構成原子の中心が存在するァミノ酸残基）を選択することが できる。変異後のアミノ酸は、 ピリミジン環 3位窒素原子に結合する水素原子が無 くなることを想定して選択すればよい。 A complex model of UPRT ase and UMP can also be used to select mutations that stabilize the complex model of UPRT ase and CMP. Since the binding position of UMP and CMP is considered to be almost the same, by using the complex model of UMP and UPRT ase created directly from the above 3D structure information, it is practically This is because amino acids involved in CMP and UPRTase interaction can be selected. In this model, for example, an amino acid residue in the vicinity of the 4-position oxo group of the pyrimidine ring of UMP (the center of the constituent atom is about 10 A, preferably about 8 A, more preferably about 5 A from the center of the oxygen atom of the oxo group). Can be selected. The amino acid after mutation may be selected assuming that the 4-position oxo group of the pyrimidine ring is replaced with an amino group. In addition, an amino acid residue in the vicinity of the nitrogen atom at the 3-position of the pyrimidine ring of UMP (amino acid residue in which the center of the constituent atom exists about 10 A, preferably about 8 A, more preferably about 5 A from the center of the nitrogen atom) ) Can be selected. The amino acid after mutation may be selected assuming that there is no hydrogen atom bonded to the nitrogen atom at the 3-position of the pyrimidine ring.
【0033】  0033
また、 UP.RTa s eと CMPとの複合体モデルを安定化させる変異の選択のた めに、 UPRTa s eとシトシン又はゥラシルとの複合体モデルを用いることもで- きる。 上述の EMBO J. (1998)17： 3219- 3232においては U P R T a s eにおけるゥ ラシルの結合について報告されている。上記の UPRTa s eと CMPとの複合体 モデル又は UPRTa s eと UMPとの複合体モデルと同様に U P RT a s eと ' シトシン又はゥラシルとの複合体モデルを作成し、前述の方法でこれらの複合体モ デルを安定化させる変異を選択すればよい。  A complex model of UPRTase and cytosine or uracil can also be used to select mutations that stabilize the complex model of UP.RTase and CMP. In EMBO J. (1998) 17: 3219-3232 mentioned above, the uracil bond in UPRTase is reported. In the same way as the above UPRTa se and CMP complex model or UPRTa se and UMP complex model, a complex model of UP RTase and 'cytosine or uracil is created, and these complex models are prepared by the method described above. Select a mutation that stabilizes Dell.
【0034】  [0034]
CPRTa s eの製造のためには、上記のように選択された変異を有する変異 U PRTa s eと CMPとの複合体モデルを上記と同様に作成し、該モデルを安定化 させる追加のアミノ酸変異を選択してもよレ、。 または、上記いずれかの複合体モデ ルを用いて選択された変異を有する変異 UPRTa s eのアミノ酸配列をもとに して、 ランダムスクリーエングを行い、 さらに活性の高い C P RT a s eを得るこ ともできる。 、  For production of CPRTase, create a complex model of UPRTase and CMP with the mutation selected as above, and select additional amino acid mutations that stabilize the model. You can do it. Alternatively, based on the amino acid sequence of the mutant UPRTase having the mutation selected using any of the above complex models, random screening can be performed to obtain a more active CP RTase. . ,
例えば、上記のスクリーニング方法に準じて、上記で選択された変異を有する変 異 UPRTa s eをコードする DNAを铸型としてエラープローン PCR法などに よりランダムな変異を有する DNAを作成し、これらの DNAを含む組換え体 DN Aを 用いて作成 ,した形質転換体を利用してスクリーニングを行うことができる。  For example, in accordance with the screening method described above, DNA having a mutation selected above is used as a saddle type DNA encoding the mutation UPRTase, and DNA having a random mutation is prepared by an error prone PCR method or the like. Screening can be performed using transformants prepared using recombinant DNA containing A.
【0035】  [0035]
上記の UP RT a s eと CMPとの複合体モデルや U P R T a s eと UMPと の複合体モデルを用いて、 UMPと CMPの構造上の差異に着目して選択される変 異以外にも、その他のモデルを安定化させる変異を選択することができる。 その他 の変異は、上記の UMPと CMPの構造上の差異に着目して選択される変異と並存 させることが好ましい。その他の選択としては例えば UPRTa s eと CMPとの 複合体モデルにおいて、 CMPを構成するいずれかの原子の中心から 1 OA程度好 ましくは 8 A程度、より好ましくは 5 A程度の範囲に構成原子の中心が存在する UIn addition to the above-mentioned UP RT ase and CMP complex model and UPRT ase and UMP complex model, other models are selected in addition to the variation selected by focusing on structural differences between UMP and CMP. Mutations that stabilize can be selected. It is preferable that other mutations coexist with mutations selected by focusing on the structural differences between UMP and CMP. As another option, for example, in a complex model of UPRTase and CMP, about 1 OA is preferred from the center of any atom constituting CMP. The center of the constituent atom is preferably in the range of about 8 A, more preferably about 5 A. U
PRTa s eのアミノ酸残基を CMPのァミノ基と親和的に相互作用するァミノ 酸残基に変更することが挙げられる。 同様に、 UPRTa s eと UMPとの複合体 モデルにおいて、 UMPを構成するいずれかの原子の中心から 10 A程度好ましく は 8 A程度、より好ましくは 5 A程度の範囲に構成原子の中心が存在する U P R T a s eのアミノ酸残基を変異させるアミノ酸残基として選択することができる。 【0036】 For example, the amino acid residue of PRTase may be changed to an amino acid residue that interacts with the CMP amino group. Similarly, in the complex model of UPRTase and UMP, the center of the constituent atom exists in the range of about 10 A, preferably about 8 A, more preferably about 5 A from the center of any atom constituting UMP. The amino acid residue of UPRTase can be selected as an amino acid residue to be mutated. [0036]
また、その他の変異の選択のために、 CPRTa s eのもう一つの基質である P RPPと UPRTa s eとの複合体モデルを作成し、該モデルを安定化させる変異 を選択することも可能である。このように選択される変異は上記の UMPと CMP の構造上の差異に着目して選択される変異と並存させることが好ましい。  In addition, for selection of other mutations, it is possible to create a complex model of PRPP and UPRTase, which is another substrate of CPRTase, and select a mutation that stabilizes the model. It is preferable that the mutation selected in this manner coexists with the mutation selected by paying attention to the structural difference between UMP and CMP.
【003 7】  [003 7]
UPRT a s eは通常はダイマーを形成するが、 GTPが結合し四量体を形成するこ とによって、 PR PPと相互作用するアミノ酸が増加し、 UPRT a s e活性が高 まることが知られている （Proc. Natl. Acad. Sci. USA (2002) 99 : 78-83.) 。  UPRT ase usually forms a dimer, but GTP binds to form a tetramer, and it is known that amino acids that interact with PR PP increase and UPRT ase activity increases (Proc Natl. Acad. Sci. USA (2002) 99: 78-83.).
CPRTa s eについても同様の傾向が予測できるため、多量体を安定化する変異 によっても、 CPRTa s e活性があがると予測できる。 したがって、 CPRT a s eの製造のために UP RT a s eに加えるアミノ酸変異は、 UPRT a s eの、 または、前述のいずれかの複合体の多量体モデルを安定化する変異を選択して行う こともできる。 Since a similar tendency can be predicted for CPRTase, it can be predicted that CPRTase activity will be increased by mutations that stabilize multimers. Therefore, amino acid mutations added to UP RT as for the production of CPRT as can also be carried out by selecting mutations that stabilize UPRT as or the multimeric model of any of the aforementioned complexes.
【0038】  [0038]
多量体モデルを安定化させる変異としては、それぞれの単量体同士の境界部分の アミノ酸をコンピューターグラフィクス上で調べ、それらの間にエネルギー的に不 安定な要素 （例えば静電的反発、立体的反発など） がある場合には不安定な要素を 除くまたは相互作用を強めるような変異を行うことができる。例えば隣接する U P RTa s eの単量体のいずれかの原子から 1 0 A程度好ましくは 8 A程度、より好 ましくは 5 A程度の範囲に構成原子の中心が存在するァミノ酸を前記の隣接する UPRT a s eの単量体と親和的に相互作用するアミノ酸残基に変更することが できる。  Mutations that stabilize the multimeric model include examining the amino acids at the boundary between each monomer on computer graphics and energeticly unstable elements between them (for example, electrostatic repulsion, steric repulsion). Etc.) can be mutated to remove unstable elements or to strengthen the interaction. For example, an amino acid having a center of the constituent atom in the range of about 10 A, preferably about 8 A, more preferably about 5 A from any atom of the adjacent UP RTase monomer is added to the adjacent atom. It can be changed to amino acid residues that interact with the monomer of UPRTase.
【0039】  [0039]
また、 EMBO J. (1998)17 : 3219- 3232.に記載されているように、 2番目と 3番 目の ストランド （B2、 B3) からなる アームと、 もう一方の単量体の 2番目、 3 番目、 4番目の αヘリックス （A2， A3, A4) の間の相互作用によって、 二量体が形 成されている。 したがって、 i8アームを含むこれらの領域 （B2， B3, A2, A3， A4) に着 目した変異を選択することが考えられる。 多量体モデルは、 UPRTa s eの三次元構造情報、 または、好ましくは前述の いずれかの複合体モデルを基に作成すればよい。特に多量体構造は、基質との結合 部位を増加させることに寄与すると考えられるため、多量体モデルは U P R T a s eと P R P Pとの複合体モデルの全体又は一部を用いて作成することも好ましレ、。 【0040】 In addition, as described in EMBO J. (1998) 17: 3219-32.32.the arm composed of the second and third strands (B2, B3) and the second of the other monomer, A dimer is formed by the interaction between the third and fourth α- helices (A2, A3, A4). Therefore, it is conceivable to select mutations focusing on these regions (B2, B3, A2, A3, A4) including the i8 arm. The multimer model may be created based on the three-dimensional structure information of UPRTase, or preferably one of the above-mentioned complex models. In particular, since the multimeric structure is thought to contribute to increasing the binding site with the substrate, it is preferable to create the multimeric model using all or part of the complex model of UPRTase and PRPP. ,. [0040]
上記のように選択された変異を有する UPRTa s eの変異蛋白質を基に、ラン ダムスクリーニングを行って、さらに活性の高い CPRTa s eを得ることもでき る。 '  Based on the UPRTase mutated protein having the mutation selected as described above, random screening can be performed to obtain a more active CPRTase. '
また、 C PRT a s eとして得られる UP RT a s eの変異蛋白質は上記のよう に選択される変異とは別に、副次的に導入される変異や、後述のように相互に変換 可能なアミノ酸への置換などのその他の変異を含んでいてもよい。変異蛋白質の製 造方法は特に限定されなレ、が、後述の具体的な蛋白質の製造で説明する遺伝子組み 換えを用いた方法によ.り製造するととができる。  In addition to the mutations selected as described above, the mutant protein of UP RTase obtained as CPRTase is a mutation introduced as a side effect, or a substitution to a mutually convertible amino acid as described below. Other mutations such as may be included. Although the production method of the mutant protein is not particularly limited, it can be produced by a method using gene recombination described in the production of a specific protein described later.
【0041】  [0041]
1. 本発明の蛋白質 （CPRTa s e) '  1. Protein of the present invention (CPRTa s e) '
本発明の CPRTa s eの例として、 以下の （a) 〜 （d) に記載の蛋白質を挙 げることができる。  As examples of CPRTase of the present invention, the following proteins (a) to (d) can be mentioned.
(a) シトシンから CMPを生成する活性を有する、 配列番号 1、 2、 または 30 で表されるアミノ酸配列を有する蛋白質、  (a) a protein having an amino acid sequence represented by SEQ ID NO: 1, 2, or 30 having an activity of generating CMP from cytosine,
(b) 配列番号 1、 2、 または 30で表されるアミノ酸配列において、 36番目、 94番目、 102番目、 141番目、 143番目および 1 98番目のアミノ酸残基 から選ばれる 1以上のアミノ酸残基が他のアミノ酸残基に置換したアミノ酸配列 を有し、 かつシトシンから CMPを生成する活性を有する蛋白質、  (b) one or more amino acid residues selected from the 36th, 94th, 102nd, 141st, 143rd and 198th amino acid residues in the amino acid sequence represented by SEQ ID NO: 1, 2, or 30 A protein having an amino acid sequence substituted with other amino acid residues and having an activity of generating CMP from cytosine,
(c) 36番目のアミノ酸残基がシスティン、 94番目のアミノ酸残基がチロシン、 102番目のアミノ酸残基がシスティン、 141番目のアミノ酸残基がロイシン、 143番目のアミノ酸残基がバリン、または 198番目のアミノ酸残基がグリシン に置換したアミノ酸配列を有する上記 （b) の蛋白質、 および  (c) 36th amino acid residue is cysteine, 94th amino acid residue is tyrosine, 102nd amino acid residue is cysteine, 141st amino acid residue is leucine, 143rd amino acid residue is valine, or 198 The protein of (b) above having an amino acid sequence in which the second amino acid residue is substituted with glycine, and
(d)上記（a；)〜（c)のいずれかの蛋白質のアミノ酸配列において、 36番目、 94番目、 102番目、 141番目、 143番目、 1 98番目、 201番目、 20 4番目おょぴ 205番目以外のアミノ酸残基から選ばれる 1以上のアミノ酸残基 が他のァミノ酸残基に置瘓したァミノ酸配列を有し、かつシトシンから CM Pを生 成する活性を有する蛋白質、  (d) In the amino acid sequence of the protein of any of the above (a;) to (c), 36th, 94th, 102nd, 141st, 143rd, 198th, 201st, 20th 4th A protein having an amino acid sequence in which at least one amino acid residue selected from amino acid residues other than the 205th amino acid residue is substituted for other amino acid residues, and having an activity of generating CMP from cytosine;
などをあげることができる。 Etc.
【0042】  [0042]
上記 （b) および （d) における 「他のアミノ酸残基」 は天然型、 非天然型のい ずれのアミノ酸であってもよい。天然型アミノ酸としては、 L—ァラニン、 Lーァ スパラギン、 Lーァスパラギン酸、 L—グルタミン、 L—グルタミン酸、グリシン、 L—ヒスチジン、 L一イソロイシン、 L一口イシン、 L一リジン、 L—アルギニン、 L—メチォニン、 L—フエニノレアラニン、 L一プロリン、 - Lーセリン、 L—スレオ ニン、 L一トリプトファン、 Lーチロシン、 Lーバリン、 L一システィンなどがあ げられる。 The “other amino acid residues” in the above (b) and (d) may be either natural or non-natural amino acids. Natural amino acids include L-alanine and L-a. Sparagin, L-aspartic acid, L-glutamine, L-glutamic acid, glycine, L-histidine, L-isoleucine, L-sip Icine, L-lysine, L-arginine, L-methionine, L-phenenolealanine, L-proline, -L-serine, L-threonine, L-tryptophan, L-tyrosine, L-valine, L-cysteine, etc.
【0 0 4 3】  [0 0 4 3]
好ましくは上記 （b ) の他のアミノ酸残基としては、 3 6番目のアミノ酸残基は システィン、 9 4番目のアミノ酸残基はチロシンまたはフエ二ルァラニン、 1 0 2 番目のアミノ酸残基はシスティン、 1 4 1番目のアミノ酸残基はロイシン、イソ口 イシン、 ノノレロイシン、 ノ リン、 ノノレバリン、 ァラニン、 2-アミノブタン酸、 メチ ォニン、 O -メチルセリン、 t-ブチルグリシン、 t -プチルァラニンおょぴシクロへ キシルァラニンから選ばれるアミノ酸、 1 4 3番目のアミノ酸残基はパリン、 ロイ シン、 イソロイシン、 ノルロイシン、 ノルバリン、 ァラニン、 2-アミノブ.タン酸、 メチォユン、 0-メチルセリン、 t -ブチルグリシン、 ΐ-ブチルァラニンおよぴシク 口へキシルァラニンから選ばれるアミノ酸、 1 9 8番目のアミノ酸残基はグリシン をあげることができる。  Preferably, as the other amino acid residues in (b) above, the 36th amino acid residue is cysteine, the 9th amino acid residue is tyrosine or phenylalanin, the 100th second amino acid residue is cysteine, 1 4 The first amino acid residue is leucine, isoorcinine, nonoleucine, norin, nonolevaline, alanine, 2-aminobutanoic acid, methionine, O-methylserine, t-butylglycine, t-ptylalanin opicyclohexylalanine 1 4 3rd amino acid residue is parin, leucine, isoleucine, norleucine, norvaline, alanine, 2-aminobutanoic acid, methoyun, 0-methylserine, t-butylglycine, ΐ-butylalanine and The amino acid selected from hexylalanin, 1 9 8th amino acid residue is glyc Can be raised.
【0 0 4 4】  [0 0 4 4]
また上記（ d )の蛋白質において、相互に置換可能なアミノ酸の例を以下に示す。 同一群に含まれるアミノ酸は相互に置換可能である。  Examples of amino acids that can be substituted for each other in the protein (d) are shown below. Amino acids included in the same group can be substituted for each other.
A群：ロイシン、イソロイシン、 ノルロイシン、バリン、 ノノレパリン、ァラユン、 2 -ァミノブタン酸、 メチォニン、 O-メチルセリン、 t-ブチルグリシン、 t -プチル ァラニン、 シクロへキシノレァラニン  Group A: Leucine, isoleucine, norleucine, valine, nonoleparin, arayun, 2-aminobutanoic acid, methionine, O-methylserine, t-butylglycine, t-ptylalananine, cyclohexinolealanine
B群：ァスパラギン酸、グ ダミン酸、ィソァスパラギン酸、イソグルタミン酸、 2 -ァミノアジピン酸、 2-アミノスべリン酸  Group B: Aspartic acid, Gudamic acid, Isospartic acid, Isoglutamic acid, 2-Aminoadipic acid, 2-Aminosuberic acid
C群：ァスパラギン、 グルタミン 、  Group C: asparagine, glutamine,
D群： リジン、 アルギニン、 オル二チン、 2， 4 -ジァミノブタン酸、 2， 3-ジァミノ プロピオン酸  Group D: Lysine, Arginine, Ornitine, 2,4-Diaminobutanoic acid, 2,3-Diaminopropionic acid
Ε群：プロリン、 3-ヒ ドロキシプロリン、 4 -ヒ ドロキシプロリン  Group: Proline, 3-hydroxyproline, 4-hydroxyproline
F群：セリン、 スレ才ニン、 ホモセリン  Group F: serine, thread-retained nin, homoserine
G群：フエニノレアラニン、 チロシン  Group G: phenenolealanine, tyrosine
上記 （b ) および （d ) の蛋白質が、 シトシンから CMPを生成する活性を有し ていることは、該蛋白質をコードする D NAを含む組換え体 D NA用いて、 P y r G (C T Pシンセクーゼ） 、 c o d A (シトシンデアミ^ "一ゼ） 、 c d d (シチジ ンデァミナーゼ） の 3つの酵素活性を喪失しているエツシエリヒア'コリを形質転 換し、得られた形質転換体が、 シトシン含有最少培地中で生育できることにより確 認することができる。 2. 本発明の DNA The above proteins (b) and (d) have the activity of generating CMP from cytosine. The use of recombinant DNA containing DNA encoding the protein, PyrG (CTP synthetase) ), Cod A (cytosine deaminase), and cdd (cytidine deaminase), which are transformed into E. coli lacking the three enzyme activities, and the resulting transformant is transformed into cytosine-containing minimal medium. This can be confirmed by being able to grow. 2. DNA of the present invention
本発明の DNAとしては、 以下の （e) および （f ) に記載の DNA  The DNA of the present invention includes the DNAs described in the following (e) and (f)
(e) 上記 1の本発明の蛋白質をコードする DNA、 および  (e) DNA encoding the protein of the present invention of 1 above, and
( f ) 配列番号 3〜 5のいずれかで表される塩基配列を有する D NA  (f) DNA having the base sequence represented by any of SEQ ID NOs: 3 to 5
などをあげることができる。 Etc.
3. 本発明の DN Aの調製  3. Preparation of DN A of the present invention
本発明の DN Aは、エツシェリヒア'コリ (Escherichia colO由来の UPRT a s eをコードする DNAに変異を導入することにより取得することができる。  The DNA of the present invention can be obtained by introducing a mutation into DNA encoding UPRT ase derived from Escherichia colO.
(1) エッシェリヒァ 'コリ由来の UP RT a s eをコードする DNAの取得 エツシエリヒア ·コリ由来の UPRT a s eをコードする DNAを取得する方法 としては、エッシェリヒァ'コリから斎藤らの方法 [Biochim. Biophys. Acta, 72, 619 (1963),]に従い調製できる染色体 DNAを鎵型として、配列番号 5で表される 塩基配列に.基づき.設計、合成するこどができるプライマー DNAを用いて: P C R等 - により取得する方法等をあげることができる。  (1) Acquisition of DNA encoding UPRTase derived from Escherichia coli The method for obtaining DNA encoding UPRTase derived from Escherichia coli is the method of Saito et al. [Biochim. Biophys. Acta, 72, 619 (1963),] is a chromosomal DNA that can be prepared according to the nucleotide sequence represented by SEQ ID NO: 5, using a primer DNA that can be designed and synthesized: PCR etc. And the like.
【004 5】  [004 5]
具体的には、 エッシェリヒァ ·コリ W3110株から染色体 DNA (配列番号 6) を 調製し、該 DNAを铸型として、例えば配列番号 7および 8で表される塩基配列を 有する DNAを化学合成し、該 DNAをプライマーセットとして用いた PCRによ り取得できる。上記方法により取得できる具体的な DN Aとしては、配列番号 5で 表される塩基配列を有する DN Aをあげることができる。 ,  Specifically, a chromosomal DNA (SEQ ID NO: 6) is prepared from Escherichia coli W3110 strain, and the DNA having the nucleotide sequence represented by SEQ ID NOs: 7 and 8, for example, is chemically synthesized using the DNA as a cage. It can be obtained by PCR using DNA as a primer set. Specific examples of DNA that can be obtained by the above method include DNA having the base sequence represented by SEQ ID NO: 5. ,
【0 04 6】  [0 04 6]
また、配列番号 5で表される塩基配列と相補的な塩基配列からなる D N Aの一部、 または全部をプローブとしたハイプリダイゼーション法によってもエツシェリヒ 了'コリ由来の UPRT a s eをコードする DNAを取得することができる。ハイ ブリダィゼ一ンヨン法は、 Molecular Cloning, A Laboratory Manual, Third Edi tion, Cold Spring Harbor Laboratory Press、 2001年 (以下、 モレキュラー ·ク ローニングと略す） に記載されている方法に準じて行うことができる。  In addition, DNA encoding UPRTase derived from Escherichia coli can also be obtained by the hybridization method using part or all of the DNA consisting of a base sequence complementary to the base sequence represented by SEQ ID NO: 5 as a probe. can do. The hybridization method can be performed in accordance with the method described in Molecular Cloning, A Laboratory Manual, Third Edition, Cold Spring Harbor Laboratory Press, 2001 (hereinafter abbreviated as “molecular cloning”).
【004 7】  [004 7]
さらに、エツシェリヒア.コリ由来の UPRT a s eをコードする DNAは、配 列番号 5で表される塩基配列に基づき、公知の方法で該塩基配列を有する DNAを 化学合成することによつても取得できる。  Furthermore, DNA encoding UPRT ase derived from Escherichia coli can also be obtained by chemically synthesizing DNA having the base sequence by a known method based on the base sequence represented by SEQ ID NO: 5.
(2) 本発明の DN Aの調製  (2) Preparation of DN A of the present invention
本発明の DNAは、 上記 （1) で得られるエツシェリヒア .コリ由来の UPRT a s eをコードする DNAに、 モレキュラー 'クローニングおよび Current Proto cols in Molecular Biology, John Wiley & Sons (1987-1997) (以下、カレントプ 口トコールズ.イン.モレキュラー.バイオロジーと略す） 等に記載された方法に 従レ、、部位特異変異を導入することにより取得することができる。 また、ェラープ ローン P C R法 [Proc. Natl. Acad. Sci. USA, 90, 5618 (1982) ]により、 配列番 号 5で表される塩基配列を有する D N Aにランダム変異を導入することによって も取得することができる。 The DNA of the present invention can be obtained by using molecular cloning and Current Protocols in Molecular Biology, John Wiley & Sons (1987-1997) (hereinafter referred to as current protocol). Mouth Tocoles in. Molecular. Biology) etc. Subordinates can be obtained by introducing site-specific mutations. It can also be obtained by introducing random mutations into DNA having the nucleotide sequence represented by SEQ ID NO: 5 by the error-prone PCR method [Proc. Natl. Acad. Sci. USA, 90, 5618 (1982)]. be able to.
【0 0 4 8】  [0 0 4 8]
また、各種生物由来の既知の U P R T a s e、例えば Toxoplasma gondi iおよび Bacillus caldolyticusなどの U P R T a s eと UM Pの複合体構造を鏡型とし、 エツシエリヒア.コリのホモロジ一モデルを作成し、 このモデルを基に UMP結合 部位付近のァミノ酸残基を抽出し、その中から本来の基質であるゥラシルからシト シンへ基質特異性を変換するのに重要な役割を果たすと推定されるアミス酸残基 を選び出し、部位特異的変異を導入してシトシンを CMPへ変換する活性を有する 蛋白質を選択することもできる。 詳細は上記の 「C P R T a s eの設計」 の項目の 記載を参照することが.できる。 '  In addition, a complex structure of UPRT ase and UMP such as Toxoplasma gondi i and Bacillus caldolyticus derived from various organisms is used as a mirror structure to create a homology model of E. coli and based on this model. The amino acid residues near the UMP binding site are extracted, and the amisic acid residues that are assumed to play an important role in converting substrate specificity from uracil, which is the original substrate, to cytosine are selected. It is also possible to select a protein having an activity of converting cytosine into CMP by introducing a site-specific mutation. For details, refer to the description of the item “CPR T a s design” above. '
4 . 本発明の蛋白質の製造 4. Production of the protein of the present invention
上記 1の本発明の蛋白質は、 モレキュラー 'クローニングゃカレントプロ トコ一 ルズ 'イン'モレキュラー 'バイオ口ジ一等に記載された方法等を用い、例えば以 下の方法により、上記 2の本発明の D N Aを宿主細胞中で発現させて製造すること ができる。  The protein of the present invention of 1 above is obtained by using the method described in Molecular 'Cloning Current Protocols' In'Molecular' Bio Mouth, etc., for example, by the following method. It can be produced by expressing DNA in a host cell.
【0 0 4 9】  [0 0 4 9]
即ち、上記 3の方法で取得できる DN Aを基にして、必要に応じて本発明の蛋白 質をコードする部分を含む適当な長さの D NA断片を調製し、該 D NA断片を適当 な発現ベクターのプロモーターの下流に揷入した組換え体 D N Aを作製する。該組 換え体 D NAを、該発現べクタ一に適合した宿主細胞に導入することにより、形質 転換体を作製することができる。  That is, based on the DNA that can be obtained by the above method 3, if necessary, a DNA fragment of an appropriate length containing a portion encoding the protein of the present invention is prepared. Recombinant DNA inserted downstream of the expression vector promoter is prepared. A transformant can be prepared by introducing the recombinant DNA into a host cell suitable for the expression vector.
【0 0 5 0】 、  [0 0 5 0],
また該 DN A断片の塩基配列を、宿主細胞の発現に最適なコドンとなるように塩 基を置換した DN Aを調製することにより、本発明の蛋白質を効率的に製造するこ ともできる。  In addition, the protein of the present invention can also be efficiently produced by preparing a DNA in which the nucleotide sequence of the DNA fragment is substituted with a base so that it becomes an optimal codon for host cell expression.
宿主細胞としては、目的とする遺伝子を発現できる細菌であればいずれも用いる ことができる。発現ベクターとしては、 上記宿主細胞において自立複製可能で、本 発明のポリペプチドをコードする D N Aを転写できる位置にプロモーターを含有 しているものが用いられる。  Any host cell can be used as long as it is capable of expressing the target gene. As the expression vector, a vector that can replicate autonomously in the above host cell and contains a promoter at a position where the DNA encoding the polypeptide of the present invention can be transcribed is used.
【0 0 5 1】  [0 0 5 1]
細菌等の原核生物を宿主細胞として用いる場合は、本発明の蛋白質をコードする D N Aを含有している組換えベクターは、原核生物中で自立複製可能であると同時 に、 プロモーター、 リボソーム結合配列、本発明の D NA、 転写終結配列、 より構 成されたベクターであることが好ましい。プロモーターを制御する遺伝子が含まれ ていてもよい。 When a prokaryotic organism such as a bacterium is used as a host cell, the recombinant vector containing the DNA encoding the protein of the present invention is capable of autonomous replication in the prokaryotic organism, and at the same time a promoter, a ribosome binding sequence, DNA of the present invention, transcription termination sequence, A constructed vector is preferred. A gene that controls the promoter may also be included.
発現べクタ一としては、例えば宿主細胞に Escherichia属に属する微生物を用い る場合には、 pBTrp2、 pBTacl, PBTac2 (いずれもベーリンガーマンハイム社より巿 販） 、 pTrc99A (Pharmacia社製） 、 pSE280 (Invitrogen社製） 、 pGEMEX- 1 (Prom ega社製） 、 pQE82L (QIAGEN社製） 、 pKYPIO (特開昭 58-110600号公報） 、 p YP2 00 [Agric. Biol. Chem.， 48, 669 (1984) ] 、 pLSAl [Agric. Biol. Chem. , 53, 277 (1989)3 、 pGELl [Proc. Natl. Acad. Sci. USA, 82, 4306 (1985)〕 、 pBlue script II SK (-) (Stratagene社製） 、 pTrs30 [Escherichia coli J1109/pTrS30Expression base Kuta foremost, when Ru using a microorganism belonging to Escherichia genus, for example a host cell, pBTrp2, pBTacl, P BTac2 (both巿sales than Boehringer Mannheim), pTrc99A (Pharmacia Co.), pSE280 (Invitrogen PGEMEX-1 (Promega), pQE82L (QIAGEN), pKYPIO (JP 58-110600), pYP200 (Agric. Biol. Chem., 48, 669 (1984) ], PLSAl [Agric. Biol. Chem., 53, 277 (1989) 3, pGELl [Proc. Natl. Acad. Sci. USA, 82, 4306 (1985)], pBlue script II SK (-) (Stratagene) ), PTrs30 [Escherichia coli J1109 / pTrS30
(FERM BP- 5407) より調製〕 、 pTrs32 [Escherichia coli JM109/pTrS32 (FERM B P-5408) より調製〕 、 pGHA2 [Escherichia coli IGHA2 - (FERM BP- 400) より調製、 特開昭 60-221091号公報〕 、 pGKA2 [Escherichia coli IGKA2 (FERM BP- 6798) よ り調製、.特開昭 60-221091号公報〕； Term2 (US4686191, US4939094、 US5160735)、 pSupex、 pUBHO, pTP5、 pC194、 pEG400 (J. Bacterid. , 172, 2392 (1990)〕 、 p GEX (Pharmacia社製） 、 pETシステム （Novagen社製） 等をあげることができ、 宿 主細胞に Corynebacterimn属に属する微生物を用レ、る場合には、 pCGl (特開昭 57- 134500号公報） 、 pCG2 (特開昭 58- 35197号公報） 、 pCG4 (特開昭 57- 183799号公 報） 、 pCGll (特開昭 57- 134500号公報) 、 pCG116、 pCE54、 pCBlOl (いずれも特開 昭 58-105999号公報） 、 pRI109 (再表 2000-44886号公報： W000/44886) 、 pCE51、 pCE52、 pCE53 [レヽずれも Molecular and General Genetics, 196, 175 (1984) ] 等 をあげることができる。 (Prepared from (FERM BP-5407)), pTrs32 (prepared from Escherichia coli JM109 / pTrS32 (FERM B P-5408)), pGHA2 (prepared from Escherichia coli IGHA2-(FERM BP-400), JP-A-60-221091 Gazette], pGKA2 (prepared from Escherichia coli IGKA2 (FERM BP-6798), JP 60-221091); Term2 (US4686191, US4939094, US5160735), pSupex, pUBHO, pTP5, pC194, pEG400 (J. Bacterid., 172, 2392 (1990)], p GEX (manufactured by Pharmacia), pET system (manufactured by Novagen), etc., when using microorganisms belonging to the genus Corynebacterimn as host cells , PCGl (Japanese Unexamined Patent Publication No. 57-134500), pCG2 (Japanese Unexamined Patent Publication No. 58-35197), pCG4 (Publication No. 57-183799), pCGll (Japanese Unexamined Patent Publication No. 57-134500), pCG116, pCE54, pCBlOl (all published in JP-A-58-105999), pRI109 (reprinted in 2000-44886: W000 / 44886), pCE51, pCE52, pCE53 (all of which are Molecular and General Genetics, 196, 1 75 (1984)].
【0 0 5 2】  [0 0 5 2]
プロモーターとしては、宿主細胞中で機能するものであればいかなるものでもよ い。 例えば、 tr プロモーター (PtrD_) 、 lacプロモーター、 PLプロモーター、 PRプ 口モーター、 T7プロモーター等の、 大腸菌やファ—ジ等に由来するプロモーター をあげることができる。 また PtrDを 2つ直列させたプロモーター （PtrDX 2 ) 、 tac プロモーター、 lacT7プロモーター、 let Iプロモーターのように人為的に設計改 変されたプロモーター等も用いることができる。 The promoter may be any as long as it functions in the host cell. For example, tr promoter (P trD _), lac promoter, P L promoter, P R-flops opening motor, such as T7 promoter, E. coli and file - it is possible to increase the promoter derived from the di-like. Artificially modified promoters such as a promoter in which two P trDs are connected in series (P trD X 2), tac promoter, lacT7 promoter, let I promoter, etc. can also be used.
【0 0 5 3】  [0 0 5 3]
リ'ポソーム結合配列であるシャイン一ダルガノ （Shine - Dalgarno)配列と開始コ ドンとの間を適当な距離 （例えば 6〜； L8塩基） に調節したプラスミドを用いるこ とが好ましい。本発明の組換えベクターにおいては、本発明の D NAの発現には転 写終結配列は必ずしも必要ではないが、構造遺伝子の直下に転写終結配列を配置す ることが好ましい。  It is preferable to use a plasmid in which the distance between the Shine-Dalgarno sequence, which is a reposome binding sequence, and the initiation codon is adjusted to an appropriate distance (eg, 6 to; L8 base). In the recombinant vector of the present invention, a transcription termination sequence is not necessarily required for expression of the DNA of the present invention, but a transcription termination sequence is preferably arranged immediately below the structural gene.
宿主細胞としては、 ェシエリヒア属 (Escherichia) 、 コリネパクテリゥム属 ½ orynebacterium)、またはブレビバタテリゥム（Brevibacterium)に属する微生物、 例えば、 Escherichia coliゝ Corynebacterium ammoniagenes. Corvnebacterium g lutamicum、 Brevibacterium immariophilum^ Brevibacterium saccharoIvticum B revibacterium flavum、ぉょぴ Brevibacterium lactofermentum等をあげ、ることカ でき、より好ましくは Escherichia coli XL1— Blue、 Escherichia coli XL2 - Blue、 Escherichia coli DH1、 Escherichia coli DH5 Escherichia coli MC1000、 Es cherichia coli MM294、 Escherichia coli ¥1485、 Escherichia coli JM109、 Esc herichia coli腿 01、 Escherichia coli No. 49、 Escherichia coli W3110s Escb erichia coli NY49、 Escherichia coli GI698、 Corvnebacterium ammoniagenes A TCC6872、 Corynebacterium ammoniagenes ATCC21170、 Corvnebacterium glutamic um ATCC13032、 Corynebacterium glutamicum ATCC21171、 Brevibacterium immarn ophilum ATCC14068、 Brevibacterium saccharolyticum . ATCC14066、 Brevibacteri uin flavum ATCC14067、 Brevibacterium lactofermentum ATCC13869等をあげるこ とができ、 さらに好ましくは Corynebacterium ammoniagenes ATCC21170, Coryneb acterium glutamicum ATCC21171をあげることができる。 Host cells include microorganisms belonging to the genus Escherichia, the genus Corynepacteria ½ orynebacterium, or Brevibacterium, For example, Escherichia coli ゝ Corynebacterium ammoniagenes. Escherichia coli DH1, Escherichia coli DH5 Escherichia coli MC1000, Es cherichia coli MM294, Escherichia coli ¥ 1485, Escherichia coli JM109, Esc herichia coli thigh 01, Escherichia coli No. 49, Escherichia coli W3110 s Escb erichia coli NY49, Escherichia coli GI Corvnebacterium ammoniagenes A TCC6872, Corynebacterium ammoniagenes ATCC21170, Corvnebacterium glutamic um ATCC13032, Corynebacterium glutamicum ATCC21171, Brevibacterium immarn ophilum ATCC14068, Brevibacterium saccharolyticum .ATCC14066, Brevibacteri uin flavum ATCC14067, Mashiku can be mentioned Corynebacterium ammoniagenes ATCC21170, Coryneb acterium glutamicum ATCC21171.
【0 0 5 4】  [0 0 5 4]
組換えベクターの導入方法としては、上記宿主細胞へ D N Aを導入する方法であ' ればいずれも用いることができ、例えば、 カルシウムイオンを用いる方法 [Proc. Natl. Acad. Sci. USA, 69, 2110 (1972)〕 、 プロトプラスト法 （特開昭 57- 18649 2号公報、 特開昭 57-18649号公報） 、 電気穿孔法 [例えば、 Journal of Bacterio logy, 175, 4096 (1993)、 Appl. Microbiol. Biotechnol. , 52, 541 (1999) ] 、 G ene, 17, 107 (1982)および Molecular & General Genetics, 168, 111 (1979)に 記載の方法等をあげることができる。  As a method for introducing a recombinant vector, any method can be used as long as it is a method for introducing DNA into the above host cell. For example, a method using calcium ions [Proc. Natl. Acad. Sci. USA, 69, 2110 (1972)], protoplast method (JP 57-18649 2 and JP 57-18649), electroporation [for example, Journal of Bacteriology, 175, 4096 (1993), Appl. Microbiol Biotechnol., 52, 541 (1999)], Gene, 17, 107 (1982) and Molecular & General Genetics, 168, 111 (1979).
【0 0 5 5】 '  [0 0 5 5] '
本発明の蛋白質の生産形態としては、そのままの構造で生産する以外に、モレキ ユラ一 ·クローニングに記載されている方法等に準じて、分泌生産、融合蛋白質と して生産することもできる。  In addition to producing the protein of the present invention as it is, the protein of the present invention can be produced as a secretory product or a fusion protein according to the method described in Molecular Cloning.
本発明の蛋白質は、上記方法で得られる形質転換体を培地に培養し、培養物中に 本発明の蛋白質を生成、蓄積させ、該培養物より本努明の蛋白質を採取することで 得ることができる。  The protein of the present invention can be obtained by culturing the transformant obtained by the above method in a medium, producing and accumulating the protein of the present invention in the culture, and collecting the protein of the present invention from the culture. Can do.
【0 0 5 6】  [0 0 5 6]
該形質転換体の培養は、 '通常の培養法によって実施することができる。  The culture of the transformant can be carried out by a 'normal culture method.
培養に供する培地としては、該形質転換体が資化し得る炭素源、窒素源、無機塩 類等を含有し、該形質転換体の培養を効率的に行える培地であれば天然培地、合成 培地のいずれを用いてもよい。 炭素源としては、例えばグルコース、 果糖、 シユークロース、 マルトース、 でん ぷん加水分解物等の糖類、 エタノールなどのアルコール類、 酢酸、 乳酸、 コハク酸 等の有機酸類を用いることができる。 濃度は 5〜400g/lが好ましい。 As a medium for culturing, a natural source or a synthetic medium may be used as long as it contains a carbon source, a nitrogen source, an inorganic salt, and the like that can be assimilated by the transformant and can efficiently culture the transformant. Any of them may be used. Examples of the carbon source include saccharides such as glucose, fructose, sucrose, maltose, and starch hydrolysate, alcohols such as ethanol, and organic acids such as acetic acid, lactic acid, and succinic acid. The concentration is preferably 5 to 400 g / l.
【0 0 5 7】  [0 0 5 7]
窒素源としては、 アンモニア、塩化アンモニゥム、硫酸アンモ-ゥム、 炭酸アン モニゥム、 酢酸アンモニゥムなどの各種無機おょぴ有機アンモニゥム塩類、 尿素、 その他窒素含有化合物、 ならびに肉エキス、 酵母エキス、 コーン'スティープ' リ カー、 大豆加水分解物等の窒素含有有機物を用いることができる。 濃度は 1〜： L00g /1が好ましい。 Nitrogen sources include ammonia, ammonium chloride, ammonium sulfate, ammonium carbonate, ammonium acetate, various organic organic ammonium salts, urea, other nitrogen-containing compounds, meat extract, yeast extract, corn steep 'Nitrogen-containing organic substances such as liquor and soybean hydrolyzate can be used. The concentration is preferably 1 to: L00 g / 1.
無機塩としてはリン酸第一水素カリゥム、 リン酸第二水素カリウム、硫酸アンモ ユウム、塩化ナトリウム、硫酸マグネシウム、炭酸カルシウム等を用いることがで さる。 .  As the inorganic salt, potassium hydrogen phosphate, potassium dihydrogen phosphate, ammonium sulfate, sodium chloride, magnesium sulfate, calcium carbonate and the like can be used. .
【0 0 5 8】  [0 0 5 8]
その他、必要に応じて、 ピオチン、 チアミン等の微量栄養源を加えることができ る。 これら微量栄養源は、 肉エキス、 酵母エキス、 コーン 'スティープ' リカー、 カザミノ酸等の天然物で代用することもできる。  In addition, micronutrient sources such as piotin and thiamine can be added as needed. These micronutrient sources can be substituted with natural products such as meat extract, yeast extract, corn 'steep' liquor and casamino acids.
培養は、 振とう培養、 深部通気撹拌培養等の好気的条件下で行う。 培養温度は 2 0°C〜50°C、 好ましくは 30°C〜42°Cが好ましく、 培地中の PHは、 4〜： 10、 好ましく は 5〜8に維持する。 pHの調整は、 無機あるいは有機の酸、. アルカリ溶液、 尿素、 炭酸カルシウム、 アンモニアなどを用いて行う。 培養時間は 12時間〜 6日間、 好 ましくは 1〜3日間である。 また、 培養中必要に応じて、 カナマイシン等の抗生物 質を培地に添加してもよい。 - 【0 0 5 9】 ' Cultivation is performed under aerobic conditions such as shaking culture and deep aeration stirring culture. Culture temperature is 2 0 ° C~50 ° C, preferably preferably 30 ° C~42 ° C, P H in the medium, 4: 10, preferably is maintained at 5-8. Adjust the pH with inorganic or organic acids, alkaline solutions, urea, calcium carbonate, ammonia, etc. The culture time is 12 hours to 6 days, preferably 1 to 3 days. In addition, an antibiotic such as kanamycin may be added to the medium as necessary during the culture. -【0 0 5 9】 '
プロモーターとして誘導性のプロモーターを用いた組換えベクターで形質転換 した微生物を培養するときには、必要に応じてィンデューサーを培地に添加しても よい。 例えば、 プ口モーターを用いた組換えべクタ一で形質転換した微生物を 培養するときにはイソプロピル一 β一 D—チォガラクトビラノシド等を、 trpプロ モーターを用いた組換えベクターで形質転換した微生物を培養するときにはィン ドールァクリル酸等を培地に添加してもよい。  When culturing a microorganism transformed with a recombinant vector using an inducible promoter as a promoter, an inducer may be added to the medium as necessary. For example, when cultivating a microorganism transformed with a recombinant vector using a plug motor, a microorganism transformed with a recombinant vector using isopropyl 1 β 1 D-thiogalactoviranoside, etc., with a trp promoter When culturing, indoleacrylic acid or the like may be added to the medium.
【0 0 6 0】  [0 0 6 0]
本発明の蛋白質の生産:^法としては、宿主細胞内に生産させる方法、宿主細胞外 に分泌させる方法、 あるいは宿主細胞外膜上に生産させる方法がある。  Production of the protein of the present invention: As a method, there are a method of producing in the host cell, a method of secreting it outside the host cell, and a method of producing it on the host cell outer membrane.
本発明の蛋白質が宿主細胞内あるいは宿主細胞外膜上に生産される場合、ポール ソンらの方法 . Biol. Chem. , 264, 17619 (1989) ) 、 ロウらの方法 〔Proc. Na tl. Acad. Sci. USA, 86. 8227 (1989)、 Genes Develop. , 4. 1288 (1990)〕 、 ま たは特開平 5-336963号公報、 W094/23021等に記載の方法を準用することにより、 該蛋白質を宿主細胞外に積極的に分泌させることができる。 When the protein of the present invention is produced in the host cell or on the outer membrane of the host cell, the method of Paulson et al. Biol. Chem., 264, 17619 (1989)), the method of Lou et al. [Proc. Sci. USA, 86. 8227 (1989), Genes Develop., 4.1288 (1990)], and Alternatively, by applying the method described in JP-A-5-336963, W094 / 23021 etc., the protein can be actively secreted outside the host cell.
【0 0 6 1】  [0 0 6 1]
すなわち、遺伝子組換えの手法を用いて、本発明の蛋白質の活性部位を含むポリ ぺプチドの手前にシグナルぺプチドを付加した形で発現させることにより、本発明 の蛋白質を宿主細胞外に積極的に分泌させることができる。  That is, by using a gene recombination technique, the protein of the present invention can be actively expressed outside the host cell by expressing the polypeptide containing the active site of the protein of the present invention with a signal peptide added in front of it. Can be secreted.
また、 特開平 2 - 227075号公報に記載されている方法に準じて、 ジヒドロ葉酸還 元酵素遺伝子等を用いた遺伝子増幅系を利用して生産量を上昇させることもでき る。  Further, according to the method described in JP-A-2-227075, the production amount can be increased by using a gene amplification system using a dihydrofolate reductase gene or the like.
【0 0 6 2】  [0 0 6 2]
本努明の形質転換体により製造された蛋白質を単離精製するためには、通常の酵 素の単離精製法を.用いる とができる。 ' . - .  In order to isolate and purify the protein produced by the transformant of this effort, the usual enzyme isolation and purification method can be used. '.-.
例えば本発明の蛋白質が、 細胞内に溶解状態で発現した場合には、 培養終了後、 - 細胞を遠心分離により回収し、水系緩衝液にけん濁後、超音波破碎機、 フレンチプ レス、 マントンガウリンホモゲナイザー、 ダイノミノレ等により細胞を破枠し、無細 胞抽出液を得る。該無細胞抽出液を遠心分離することにより得られる上清から、通 常の酵素の単離精製法、 即ち、 溶媒抽出法、 硫安等による塩祈法、 脱塩法、 有機溶 媒による沈殿法、 ジェチルアミノエチル （DEAE) —セファロース、 M AION HPA-75 (三菱化成社製) 等のレジンを用いた陰イオン交換クロマトグラフィ一法、 S - Sep harose FF (Pharmacia社製） 等のレジンを用いた陽ィオン交換ク口マトグラフィ 一法、 ブチルセファロース、 フエ二ルセファロース等のレジンを用いた疎水性ク口 マトグラフィ一法、分子篩を用いたゲルろ過法、ァフィ二ティーク口マトグラフィ 一法、 クロマトフォーカシング法、等電点電気泳動等の電気泳動法等の手法を単独 あるいは組み合わせて用レ、、 精製標品を得ることができる。  For example, when the protein of the present invention is expressed in a dissolved state in cells, after completion of the culture, the cells are collected by centrifugation, suspended in an aqueous buffer, and then an ultrasonic breaker, French press, Mantongaurin. The cells are broken with a homogenizer, dynominole, etc. to obtain a cell-free extract. From the supernatant obtained by centrifuging the cell-free extract, ordinary enzyme isolation and purification methods, that is, solvent extraction methods, salt praying methods using ammonium sulfate, desalting methods, precipitation methods using organic solvents, etc. , Jetylaminoethyl (DEAE) — Sepharose, anion exchange chromatography using resin such as M AION HPA-75 (Mitsubishi Kasei), resin such as S-Sepharose FF (Pharmacia) Cation exchange matrix chromatography method, hydrophobic chromatography method using resins such as butyl sepharose and phenyl sepharose, gel filtration method using molecular sieve, affinity matrix method, chromatofocusing method In addition, a preparation or a purified preparation can be obtained by using a method such as electrophoresis such as isoelectric focusing alone or in combination.
【0 0 6 3】 ，  [0 0 6 3],
また、該蛋白質が細胞内に不溶体を形成して発現した場合は、同様に細胞を回収 後、.破砕し、遠心分離を行うことにより、沈殿画分として蛋白質の不溶体を回収す ることができる。回収した蛋白質の不溶体を蛋白質変性剤で可溶化すればよレ、。該 可溶化液を希釈または透析し、該可溶化液中の蛋白質変性剤の濃度を下げることに より、該蛋白質を正常な立体構造に戻すことができる。該操作の後、上記と同様の 単離精製法により該蛋白寳の精製標品を得ることができる。.  If the protein is expressed in the form of an insoluble substance in the cell, the cell is recovered in the same manner, and then crushed and centrifuged to recover the protein insoluble substance as a precipitate fraction. Can do. Solubilize the recovered protein insolubles with a protein denaturant. The protein can be returned to a normal three-dimensional structure by diluting or dialyzing the solubilized solution and reducing the concentration of the protein denaturant in the solubilized solution. After the operation, a purified preparation of the protein can be obtained by the same isolation and purification method as described above. .
【0 0 6 4】 .  [0 0 6 4].
本発明の蛋白質、あるいは該蛋白質に糖鎖の付加された蛋白質等の誘導体が細胞 外に分泌された場合には、培養上清に該蛋白質あるいは該蛋白質の誘導体を回収す ることができる。即ち、該培養物を上記と同様の遠心分離等の手法により処理する ことにより培養上清を取得し、該培養上清から、上記と同様の単離精製法を用いる ことにより、 精製標品を得ることができる。 When the protein of the present invention or a derivative such as a protein having a sugar chain added to the protein is secreted outside the cell, the protein or the protein derivative can be recovered in the culture supernatant. That is, the culture is treated by a method such as centrifugation as described above. Thus, a purified preparation can be obtained from the culture supernatant by using the same isolation and purification method as described above.
【0 0 6 5】  [0 0 6 5]
このようにして取^ =.される蛋白質として、上記 1の蛋白質をあげることができる。 5 . 本発明の CM Pの製造法  As the protein thus removed, the above protein 1 can be mentioned. 5. Manufacturing method of CMP of the present invention
上記 4の方法で得られる形質転換体の培養物または該培養物の処理物、シトシン、 リン酸基供与体およびエネルギー供与体を水性媒体中に存在せしめ、該媒体中に C M Pを生成、蓄積させ、該媒体中から CM Pを採取することにより CM Pを取得す ることができる。 .  A culture of the transformant obtained by the above method 4 or a processed product of the culture, cytosine, a phosphate group donor and an energy donor are present in an aqueous medium, and CMP is generated and accumulated in the medium. The CM P can be acquired by collecting the CM P from the medium. .
【0 0 6 6】  [0 0 6 6]
また、上記 4の方法で得られる形質転換体の培養物または該培養物の処理物、 コ リネパクテリゥ.ム属に属する微生物の培養物または該培養物の処理物、 シトシン、 リン酸基供与体およびエネルギー供与体を水性媒体中に存在せしめ、該媒体中に C - M Pを生成、蓄積させ、該媒体から CM Pを採取することよっても CM Pを取得す ることができる。 '  In addition, a culture of the transformant obtained by the above method 4 or a treated product of the culture, a culture of a microorganism belonging to the genus Corynepacteria, or a treated product of the culture, cytosine, a phosphate group donor, and CMP can also be obtained by allowing an energy donor to be present in an aqueous medium, generating and accumulating C-MP in the medium, and collecting CMP from the medium. '
形質転換体を培養する方法としては、上記 4の形質転換体の培養法と同様の方法 を用いればよい。 該形質転換体は、 湿菌体として 0. 5〜500g/l、 好ましくは 5〜20 Og/1の濃度で用いられる。  As a method for culturing the transformant, a method similar to the method for culturing the transformant described in 4 above may be used. The transformant is used as wet cells at a concentration of 0.5 to 500 g / l, preferably 5 to 20 Og / 1.
【0 0 6 7】  [0 0 6 7]
基質として用いるシトシンは、合成品でも天然品でもよい。 またシトシンを含有 するものであれば精製品、天然物から得られたシトシン含有粗精製物などいずれで もよい。 シトシンは l〜100g/l、 好ましくは l〜50g/lの濃度で用いられる。  The cytosine used as a substrate may be a synthetic product or a natural product. Moreover, as long as it contains cytosine, it may be a purified product or a cytosine-containing crude product obtained from a natural product. Cytosine is used at a concentration of 1-100 g / l, preferably 1-50 g / l.
エネノレギー供与体としてはグノレコース、 フラグトース、 シユークロース、 糖蜜、 澱粉加水分解物などの炭水化物、 ピルビン酸、乳酸、酢酸、 α;—ケトグルタル酸な どの有機酸、 グリシン、 ァラニン、 ァスパラギン酸、 グルタミン酸などのアミノ酸 等の上記した形質転換体が代謝し、細胞内で ΑΤΡなどを生成することができる物質 であれば、 いずれでもよい。 これらは 5〜200g/lの濃度で用いられる。 Examples of energy donors include carbohydrates such as gnolecose, fragose, sucrose, molasses, starch hydrolysate, organic acids such as pyruvic acid, lactic acid, acetic acid, α; -ketoglutaric acid, amino acids such as glycine, alanine, aspartic acid, glutamic acid, etc. Any of the above-mentioned transformants can be used as long as they are metabolized and can generate sputum or the like in the cell. These are used at a concentration of 5 to 200 g / l.
【0 0 6 8】  [0 0 6 8]
リン酸基供与体としては正リン酸、 ピロリン酸、 トリポリリン酸、 テトラポリリ ン酸、 テトラポリメタリン酸などのポリリン酸、 ポリメタリン酸、 リン酸一力リゥ ム、 リン酸二カリウム、 リン酸一ナトリウム、 リン酸ニナトリウムなどの無機のリ ン酸塩などをあげることができる。 これらは l〜50g/lの濃度で用いられる。  Phosphoric acid group donors include orthophosphoric acid, pyrophosphoric acid, tripolyphosphoric acid, tetrapolyphosphoric acid, polyphosphoric acid such as tetrapolymetaphosphoric acid, polymetaphosphoric acid, monolithic phosphate, dipotassium phosphate, monosodium phosphate, Examples thereof include inorganic phosphates such as disodium phosphate. These are used at a concentration of 1-50 g / l.
コリネパクテリゥム属に属する微生物としては、 Corynebacterium ammoniagene sおよび Corynebacterium glutamicum等をあげることができ、 より好ましくは rynebacterium ammoniagenes ATCC6872、 Corynebacterium ammoniagenes ATCC211 70、 Corynebacterium glutamicum ATCC13032、 Corvnebacterium glutamicum ATCC 21171等をあげることができる。 コリネバクテリウム属に属する微生物は、 上記 4 と同様の方法で培養することができる。 コリネパクテリゥム属に属する微生物は、 湿菌体として 0. 5〜500g/l、 好ましくは 5〜200g/lの濃度で用いられる。 Examples of microorganisms belonging to the genus Corynebacterium include Corynebacterium ammoniagenes and Corynebacterium glutamicum, and more preferably rynebacterium ammoniagenes ATCC6872, Corynebacterium ammoniagenes ATCC211 70, Corynebacterium glutamicum ATCC13032, Corvnebacterium glutamicum ATCC 21171 etc. can be raised. Microorganisms belonging to the genus Corynebacterium can be cultured by the same method as described in 4 above. A microorganism belonging to the genus Corynepacteria is used as a wet cell in a concentration of 0.5 to 500 g / l, preferably 5 to 200 g / l.
【0 0 6 9】  [0 0 6 9]
水性媒体としては、例えば水、 リン酸緩衝液、 トリス緩衝液、 ホウ酸緩衝液など CMP生産反応を阻害しない塩類を含む水溶液があげられる。また形質転換体また はコリネバタテリゥム属に属する微生物を培養して得られる培養物の上清をその まま水性媒体として用いることもできる。  Examples of the aqueous medium include aqueous solutions containing salts that do not inhibit the CMP production reaction, such as water, phosphate buffer, tris buffer, and borate buffer. In addition, the supernatant of a culture obtained by culturing a transformant or a microorganism belonging to the genus Corynebataterium can be used as an aqueous medium as it is.
また上記水性媒体には必要に応じて界面活性剤または有機溶媒を添加してもよ レ、。界面活性剤または有機溶媒を添加することにより、 CMPの生産効率をあげる ことができる。  Further, a surfactant or an organic solvent may be added to the aqueous medium as necessary. The production efficiency of CMP can be increased by adding a surfactant or an organic solvent.
【0 0 7 0】  [0 0 7 0]
界面活性剤としては、ポリエチレンダリコールステアリルアミン（例えばナイミ ' ーン S— 215、 日本油脂社製） 、 アルキルジメチルベンジルアンモニゥムクロライ ド （例えばサ-ゾール B-50、 花王社製） などのカチオン性界面活性剤、 ラウリル 硫酸ナトリウム （例えばパーソフト SL、 日本油脂社製） などのァニオン性界面活 性剤、 ポリエチレングリコールソルビタンモノステアレート (例えばノニオン ST2 21、 日本油脂社製） などの非イオン性界面活性剤、 ジメチルラウリルべタイン （例 えば二.ッサンァノン BL、 日本油脂社製） などの両性界面活性剤などがあげられ、 これらは通常 0. l〜20g/l、 好ましくは l〜10g/lの濃度で用いられる。  Examples of surfactants include polyethylene dallicol stearylamine (for example, Nimene S-215, manufactured by Nippon Oil & Fats Co., Ltd.), alkyldimethylbenzyl ammonium chloride (for example, Sarsol B-50, manufactured by Kao Corporation), etc. Nonionics such as cationic surfactants, anionic surfactants such as sodium lauryl sulfate (for example, Persoft SL, manufactured by NOF Corporation), polyethylene glycol sorbitan monostearate (for example, nonion ST221, manufactured by NOF Corporation) Amphoteric surfactants such as ionic surfactants, dimethyl lauryl betaine (for example, Nissannon BL, manufactured by Nippon Oil & Fats Co., Ltd.), and these are usually 0.1 to 20 g / l, preferably l to 10 g / l. Used at a concentration of l.
【0 0 7 1】  [0 0 7 1]
有機溶媒としては、 トルエン、 キシレン、 脂肪族アルコール、 アセトン、 酢酸ェ チルなどがあげられ、 これらは通常 0. l〜50ml/l; 好ましくは l〜20ml/lの濃度で 用いられる。  Examples of the organic solvent include toluene, xylene, aliphatic alcohol, acetone, and ethyl acetate, and these are usually used at a concentration of 0.1 to 50 ml / l; preferably 1 to 20 ml / l.
CM Pの生産反応は通気撹拌等により好気的条件下で行う。反応温度は 20°C〜5 0°C、 好ましくは 30°C〜42°C、 培地中の pHは、 4〜10、 好ましくは 5〜8に維持す る。 pHの調整は、無機あるいは有機の酸、 アルカリ溶液、尿素、炭酸カルシウム、 アンモニアなどを用いて行う。 反応時間は通常 1〜48時間である。  The production reaction of CMP is carried out under aerobic conditions such as by aeration stirring. The reaction temperature is maintained at 20 ° C. to 50 ° C., preferably 30 ° C. to 42 ° C., and the pH in the medium is maintained at 4 to 10, preferably 5 to 8. The pH is adjusted using inorganic or organic acids, alkaline solutions, urea, calcium carbonate, ammonia, etc. The reaction time is usually 1 to 48 hours.
【0 0 7 2】  [0 0 7 2]
反応終了後、菌体などの沈殿物を除去して得られた反応液より、活性炭処理、ィ オン交換樹脂処理などの公知の方法を併用することにより CMPを単離精製する ことができる。  After completion of the reaction, CMP can be isolated and purified from the reaction solution obtained by removing precipitates such as bacterial cells by using a known method such as activated carbon treatment or ion exchange resin treatment.
また、 CMPを基質として又は CMPを経由して生産される有用物質の製造法に おいて、本発明の CM Pの製造法により水性媒体中に生成、蓄積する CM P又は水 性媒体中から採取した CMPを用いることができる。 上記のようにして生産される有用物質としては例えば、シチジン一 5 ' —トリリ ン酸、 CM P—シアル酸、 C D P—コリン等を挙げることができる。 In addition, in the method for producing useful substances produced using CMP as a substrate or via CMP, it is collected from CMP or aqueous medium produced and accumulated in an aqueous medium by the CMP method of the present invention. CMP can be used. Examples of useful substances produced as described above include cytidine 15′-triphosphoric acid, CMP-sialic acid, CDP-choline and the like.
CMPを基質としてシチジン一 5 '—トリリン酸を製造する方法としては、例え ば特開 2002-085087号公報およぴ特開 2000-217593号公報に記載の方法があげるこ とができ、 CM P—シアル酸を製造する方法としては、 例えば特開平 5-276973号 公報、 TO2004009830およぴ特開 2002-085087号公報に記載の方法をあげることが でき、 CDP-コリンを製造する方法としては、例えば特開昭 63 - 313594号公報および 特公昭 48-2358号公報に記載の方法をあげることができる。  Examples of methods for producing cytidine 15′-triphosphate using CMP as a substrate include the methods described in JP-A-2002-085087 and JP-A-2000-217593. —Examples of methods for producing sialic acid include the methods described in JP-A-5-76973, TO2004009830 and JP-A-2002-085087. Examples of methods for producing CDP-choline include For example, the methods described in JP-A-63-313594 and JP-B-48-2358 can be mentioned.
実施例  Example
以下に本発明の実施例を示すが、本発明はこれらの実施例に限定されるものでは ない。  Examples of the present invention are shown below, but the present invention is not limited to these examples.
【0 0 7 3】  [0 0 7 3]
例 1 , Example 1 ,
活性検出用宿主菌の造成 Construction of host bacteria for activity detection
シトシンとホスホリボシルピロリン酸 （P R P P ) から CMPを生成する酵素活 性を検出するための宿主菌 MC1000 A codA A cdd ApyrG: :Km株を以下のようにし て造成した。  A host fungus MC1000 A codA Acdd ApyrG:: Km was constructed as follows to detect the enzyme activity for producing CMP from cytosine and phosphoribosyl pyrophosphate (PRPPP).
( 1 ) シトシンデァミナーゼをコードする遺伝子 (codA遺伝子) およぴシチジン デァミナ一ゼをコ一ドする遺伝子 (^^遺伝子)欠損株の調製  (1) Preparation of a gene-deficient strain that codes for cytosine deaminase (codA gene) and cytidine deaminase (^^ gene)
Escherichia coli MClOOOの染色体 D N A上の codA遺伝子及ぴ cdd遺伝子が欠 損した菌株は、ラムダファージの相同組換え系を利用した方法 (Proc. Natl. Acad Sci. USA, 97, 6640- 6645 (2000))に準じて作製した。  A strain lacking the codA gene and cdd gene on the chromosomal DNA of Escherichia coli MClOOO can be obtained by a method using the homologous recombination system of lambda phage (Proc. Natl. Acad Sci. USA, 97, 6640-6645 (2000) ).
【0 0 7 4】  [0 0 7 4]
Escherichia coli MClOOOの染色体 D NAは、該微生物を公知の方法によって培 養し、 培養後カレント 'プロトコールズ'イン 'モレキュラー 'バイオロジーに記 載の方法により単離精製した。 プラスミド pKD46、 pKD3、 p D4および pCP20は、 ェ シエリヒア 'コリ ジェネティックストックセンター （米国エール大学） から該プ ラスミドを保持するェシヱリヒア ·コリ株を入手し、該大腸菌から抽出したものを 用いた。  Chromosomal DNA of Escherichia coli MClOOO was cultivated by a known method and isolated and purified by the method described in Current “Protocols” in “Molecular” biology after culturing. Plasmids pKD46, pKD3, pD4 and pCP20 were obtained from Escherichia coli strains carrying the plasmid obtained from the Escherichia coli genetic stock center (Yale University, USA) and extracted from the Escherichia coli.
【0 0 7 5】  [0 0 7 5]
配列番号 6に表される Escherichia coliの codA遺伝子を含む塩基配列のうち、 塩基番号 1 - 1031番目おょぴ 2094 - 3105番目で表される塩基配列部分を P C R反 応により.増幅した。 これらの増幅断片を、 pKD4を錶型とし、 配列番号 7および 8 で表される塩基配列からなる D NAをプライマーセットに用いて増幅して得られ た に FRT (FLP recognition target) サイトを持つ §ph I, aminoglycoside pho sphotransf erase)■遺伝子断片と連結した。 【0 0 7 6】 Of the nucleotide sequence containing the Escherichia coli codA gene represented by SEQ ID NO: 6, the nucleotide sequence portion represented by nucleotide numbers 1-1031 to 2094-3105 was amplified by PCR reaction. These amplified fragments are obtained by amplifying DNA using the DNA sequence consisting of the nucleotide sequences represented by SEQ ID NOs: 7 and 8 as a primer set with pKD4 as a saddle and having an FRT (FLP recognition target) site. ph I, aminoglycoside pho sphotransf erase) ■ ligated with gene fragment. [0 0 7 6]
該連結断片を、 あらかじめ PKD46を導入し、 Red recombinaseを誘導発現さ せた Escherichia coli MC1000株にエレクトロポレーション法により導入した。力 ナマイシン耐性を指標に形質転換体を選択し、 染色体上の codA遺伝子に aph遣伝 子が挿入されたことにより該遺伝子が破壌された株を取得した。  The ligated fragment was introduced into an Escherichia coli MC1000 strain into which PKD46 had been introduced in advance and Red recombinase was induced and induced by electroporation. Transformants were selected using the resistance to namycin as an index, and a strain in which the aph gene was inserted into the codA gene on the chromosome to disrupt the gene was obtained.
次に配列番号 9で表される Escherichia coliの 遺伝子を含む塩基配列のう ち、 塩基番号 1-1011番目おょぴ 1656-2572番目で表される塩基配列部分を P C R 反応により増幅した。 これらの増幅断片を、 pKD3を铸型とし、 配列番号 1 0およ び 1 1で表される塩基配列からなる D NAをプライマーセットに用いて增幅して 得られた両端に FRTサイトを持つ cat (chloramphenicol acetyltransf erase) ¾ 伝子断片を連結した。  Next, of the base sequence containing the Escherichia coli gene represented by SEQ ID NO: 9, the base sequence portion represented by base numbers 1-1011 and 1656-2572 was amplified by PCR reaction. These amplified fragments are cats with FRT sites at both ends, obtained by amplifying pKD3 in a saddle type and using DNA consisting of the nucleotide sequences represented by SEQ ID NOs: 10 and 11 as a primer set. (chloramphenicol acetyltransf erase) ¾ Gene fragments were ligated.
【 0 0 7 7】 ： 該連結断片を、 λ Red recombinaseを誘導発現させた上記で取得した力.ナマイ シン耐性株にエレクトロポレーシヨン法により導入した。カナマイシンおょぴクロ ラムフエ二コール耐性を指標に形質転換体を選択し、さらに染色体上の 遺伝子 に cat遺伝子が揷入されたことにより該遺伝子が破壊された株を取得した。  The ligated fragment was introduced by electroporation into the force-namaicin resistant strain obtained as described above in which λ Red recombinase was inducibly expressed. A transformant was selected based on kanamycin opichlorfumicoleicol resistance as an index, and a strain in which the gene was disrupted by insertion of the cat gene into the gene on the chromosome was obtained.
上記で取得したカナマイシンおょぴクロラムフエ二コール耐性株から PKD46を 除去した後、 pCP20.を導入して FLP recombinaseを誘導発現させ培養した後、染色 体 D NAから^!、 cat遺伝子が取り除かれた株を、 カナマイシンおょぴクロラム フエ二コール感受性を指標に選択した後、 pCP20を除去した。  After removing PKD46 from the kanamycin opichloramphenicol resistant strain obtained above, pCP20. Was introduced and FLP recombinase was induced and cultured, and then the chromosomal DNA ^! And the cat gene were removed. The strains were selected using kanamycin opichlorchlorphenicol sensitivity as an index, and then pCP20 was removed.
【0 0 7 8】  [0 0 7 8]
上記操作で得られた株は、 Escherichia coli MC1000株の染色体 D N A上の配列 番号 6で表される塩基配列中の 1032 - 2093番目、 およぴ配列番号 9で表される塩 基配列中の 1012 - 1655番目で表される塩基配列に相当する部分が欠失している、 すなわち codA遣伝子およぴ cdd遺伝子が欠損している Escherichia coli MC1000 株であり、 該株を Escherichia coli MClOOOAcodAAcddと命名した。  The strain obtained by the above operation is 1032-2093 in the nucleotide sequence represented by SEQ ID NO: 6 on the chromosomal DNA of Escherichia coli MC1000 strain, and 1012 in the nucleotide sequence represented by SEQ ID NO: 9. -The Escherichia coli MC1000 strain lacking the portion corresponding to the base sequence represented by the 1655th, ie, lacking the codA gene and the cdd gene, and was named Escherichia coli MClOOOAcodAAcdd did.
( 2 ) CTPシンターゼをコードする遺伝子 (pyrG遺伝子) 破壌株の調製  (2) Gene encoding CTP synthase (pyrG gene)
Escherichia coli匪 294株の染色体 DNAから、 pyrG遺伝子の一部である配列番 号 1 2で表される塩基配列からなる D NAを常法に従って調製し、 UC19の BamHI 認識部位と 1認識部位の間に連結した。  From the chromosomal DNA of Escherichia coli 294 strain 294, a DNA consisting of the nucleotide sequence represented by SEQ ID NO: 12 that is part of the pyrG gene is prepared according to a conventional method, and between the BamHI recognition site and 1 recognition site of UC19. Connected.
【0 0 7 9】  [0 0 7 9]
得られた組換えプラスミド D N Aを で消化した後平滑化し、 PUC4K (アマシ ャムバイォサイェンス社から購入）を 2§sHIで消化した後平滑化して得た、 pUC4K 由来の aph遺伝子を含む約 1. 3kbの DNA断片と連結した。 得られたプラスミド DNAを ^HIと ¾nlで消化した後精製することで、 pyrG 遺伝子中に aph遺伝子が揷入されたことにより該遺伝子が破壌された欠損型 pyrG 遺伝子断片を取得した。 The obtained recombinant plasmid DNA was digested with and then smoothed, and PUC4K (purchased from Amersham Biosciences) was digested with 2§sHI and smoothed, and contained about aph gene derived from pUC4K. 1. Ligated with a 3 kb DNA fragment. The obtained plasmid DNA was digested with ^ HI and ¾nl and then purified to obtain a defective pyrG gene fragment in which the aph gene was inserted into the pyrG gene and the gene was disrupted.
【0080】  [0080]
該 DNA断片を Escherichia coli JC7623株にエレクトロポレーション法によ り導入し、カナマイシン耐性を指標にして形質転換株を選択し、 さらにシチジン要 求性を示す株を単離した。  The DNA fragment was introduced into Escherichia coli JC7623 by electroporation, a transformant was selected using kanamycin resistance as an indicator, and a strain exhibiting cytidine requirement was isolated.
常法に従い、 単離した株から PI lysateを調製し、 Escherichia coli MM294株 に感染させ、 カナマイシン耐性を示す株を選択することにより、 pyrG遺伝子に aP 遺伝子が揷入されたことにより染色体 DN A上の該遺伝子が破壊された株を取 得し、 該株を Escherichia coli MM294ApyrG:： Kmと命名した。 According to a conventional method, a PI lysate was prepared from a strain isolated, infected with Escherichia coli MM294 strain by selecting a strain showing resistance to kanamycin, chromosomal DN A by a P gene is揷入the pyrG gene The above strain in which the gene was disrupted was obtained, and the strain was named Escherichia coli MM294ApyrG :: Km.
(3) Escherichia coli MC1000 厶 codA Acdd ApyrG: :Km株の調製  (3) Preparation of Escherichia coli MC1000 厶 codA Acdd ApyrG:: Km strain
常法に従って、上記（2) で得られた Escherichia coli画 294 pyrG:: Km株から - PI lysateを調製し、 上記 （1) で得られた MClOOOAcodAAcdd株に感染させ、 力 ナマイシン耐性を指標に形質導入株を選択した。 得られた形質導入株は codA遣伝 子および cdd遺伝子が欠損し、 かつ pyrG遺伝子が破壊された株であり、 該株を ¾ cherichia coli MClOOOAcodAAcddApyrG:： Kmと命名した。  In accordance with a conventional method, prepare -PI lysate from Escherichia coli 294 pyrG :: Km strain obtained in (2) above and infect the MClOOOAcodAAcdd strain obtained in (1) above. The introduced strain was selected. The obtained transduced strain was a strain in which the codA gene and the cdd gene were deleted and the pyrG gene was disrupted, and this strain was named ¾ cherichia coli MClOOOAcodAAcddApyrG :: Km.
【008 1】  [008 1]
Escherichia coli MC1000 AcodA Acdd ApyrG: :Km株はシチジン要求性で、 50 mg/1のシトシンを含む M 9最少寒天培地 [グルコース 1.8g、 リン酸一水素ナト リウム 6g、 リン酸ニ水素力リウム 3g、塩ィ匕ナトリウム 0.5g、塩化ァンモ-ゥ ム lg、硫酸マグネシウム · 7水和物 0.25g、塩化カルシウム · 2水和物 15mg、 チアミン塩酸塩 10mg、 Agar- Noble (Difco社製） ' 20gを水 11に含む] では生育で きないことを確認した。 すなわち、 Escherichia coli MCI 000 AcodA Acdd A y ^: :&11株に変異型1；?1 丁 & s eを発現するプラスミドを導入して得られる形質 転換体は、該変異型酵素がシトシンから CMPを生成する活性を有している場合に のみ、 シトシンを含む M 9最少培地で生育可能となる。 Escherichia coli MC1000 AcodA Acdd ApyrG:: Km strain is Cytidine-required, M 9 minimal agar medium containing 50 mg / 1 cytosine [Glucose 1.8 g, Sodium monohydrogen phosphate 6 g, Hydrogen dihydrogen phosphate 3 g, Sodium salt 0.5 g , ammonium chloride lg, magnesium sulfate heptahydrate 0.25 g, calcium chloride dihydrate 15 mg, thiamine hydrochloride 10 mg, Agar-Noble (Difco) '20 g in water It was confirmed that it was not able to grow with [Included in 11]. In other words, in the transformant obtained by introducing a plasmid expressing mutant type 1;? 1 and se into Escherichia coli MCI 000 AcodA AcddA y ^:: & 11, the mutant enzyme generates CMP from cytosine. It can grow on M9 minimal medium containing cytosine only if it has the activity to do so.
【008 2】  [008 2]
例 2 Example 2
Escherichia coli由来の野生型 UP RT a s eのクローニング  Cloning of wild type UP RT as from Escherichia coli
まず、公知の方法によりエツシヱリヒア.コリ W3110株の染色体 DNAを調製し、 次いで、該染色体 DN Aを铸型とし、配列番号 1 3および 14で表される塩基配列 からなる DNAをプライマーセットに用いて、 Pyrobest DNAポリメラーゼ （宝酒 造社製） を使用して PC Rを行った。  First, chromosomal DNA of Escherichia coli W3110 strain is prepared by a known method, and then the chromosomal DNA is used as a saddle and DNA comprising the nucleotide sequence represented by SEQ ID NOs: 13 and 14 is used as a primer set. PCR was performed using Pyrobest DNA polymerase (Takara Shuzo).
【008 3】 P C Rにより得られた約 0. 7kbの増幅産物を Qiagen PCR Purificatin Kit (Qia gen社製） を用いて精製し、 1および^ HIで切断した。 該制限酵素処理物を ァガロースゲル電気泳動した後、 Qiagen Gel Extraction Kit (Qiagen社製） を用 いて抽出、 精製した。 [008 3] The approximately 0.7 kb amplified product obtained by PCR was purified using Qiagen PCR Purificatin Kit (Qiagen) and cleaved with 1 and ^ HI. The restriction enzyme-treated product was subjected to agarose gel electrophoresis, and then extracted and purified using Qiagen Gel Extraction Kit (manufactured by Qiagen).
該 D NA断片を、同じく EcoRIおよび BamHIで切断した発現ベクター pTrc99A (P harmacia社製） と、 DNA Ligatin Kit ver. 2. 0 (宝酒造社製） を用いて結合し、 得 られた結合物を用いてエッシェリヒァ 'コリ DH5 a (東洋紡社製）を形質転換した。  The DNA fragment was ligated using the expression vector pTrc99A (manufactured by Pharmacia), also cleaved with EcoRI and BamHI, using DNA Ligatin Kit ver. 2.0 (manufactured by Takara Shuzo), and the resulting conjugate was used. Escherichia coli DH5a (Toyobo Co., Ltd.) was transformed.
【0 0 8 4】  [0 0 8 4]
アンピシリン耐性を指標に形質転換株を選択し、得られた該形質転換株を ΙΟΟ μ g/mlのアンピシリンを含む L B培地で終夜培養した。得られた培養物から Qiagen Plasmid Miniprep Kit (Qiagen社製） を用いてプラスミド D N Aを調製し、 塩基 配列を解析することで、該プラスミドは、 目的とするエツシェリヒア'コリの U P R T a s e遺伝子を含む約 0. 7kbの D N A断片が挿入された構造を有するプラスミ ドであることを確認し、 該プラスミドを pEUPlと命名した。  A transformant was selected using ampicillin resistance as an indicator, and the obtained transformant was cultured overnight in an LB medium containing ΙΟΟμg / ml ampicillin. Plasmid DNA is prepared from the obtained culture using Qiagen Plasmid Miniprep Kit (manufactured by Qiagen), and the nucleotide sequence is analyzed. As a result, the plasmid contains approximately 0% of the Escherichia coli UPRT ase gene. It was confirmed that the plasmid had a structure with a 7 kb DNA fragment inserted, and the plasmid was named pEUPl.
【0 0 8 5】  [0 0 8 5]
例 3 Example 3
U P R T a s eの三次元構造情報の例  Example of 3D structure information of U P R T a s e
Escherichia coli由来の野生型 U P R T a s eの結晶構造解析を下記に示す通 り行った。  The crystal structure analysis of wild-type UPPRase derived from Escherichia coli was performed as shown below.
<結晶化用リコンビナント野生型 UPRTaseの調製 >  <Preparation of recombinant wild-type UPRTase for crystallization>
X線結晶構造解析のための結晶調製に用レ、たリコンビナント野生型 UPRTaseは以 下のように調製した。 UPRTaseをコードする upp遺伝子の読み枠（オープンリーデ ィングフレーム）のァミノ末端は Met - 10から開始するものとし、 Cys - 160は分子表 面に位置することが予想され精製酵素の濃縮時に凝集の原因となる可能性があつ たため、 これを Serに置換した。 以上の形に対応する遺伝子領域を増幅するため.、 以下の 4種類のプライマーを用い、 プラスミド pQE82L (Qiagen社）にクローニング された野生型 upp遺伝子を鎵型として、 フュージョン PCRを行なった。  Recombinant wild-type UPRTase was prepared as follows for crystal preparation for X-ray crystal structure analysis. The reading frame of the upp gene encoding UPRTase (open reading frame) is assumed to start with Met-10, and Cys-160 is expected to be located on the molecular surface, causing aggregation when the purified enzyme is concentrated. This was replaced with Ser. In order to amplify the gene region corresponding to the above shape, fusion PCR was performed using the following four types of primers, using the wild-type upp gene cloned in the plasmid pQE82L (Qiagen) as a cocoon.
【0 0 8 6】  [0 0 8 6]
配列番号 3 4および 3 5で表される塩基配列を有する pQE_C160S_Nlと pQE— C160S一 N2、 配列番号 3 6および 3 7で表される塩基配列を有する pQE— C160S一 C1 と pQE_C160S_C2をそれぞ プライマーとした PCRを別々に行い、 それぞれの産物 をァガロース電気泳動により精製した。 引き続き、 それらを混合し铸型として、 pQE_C160S_Nlと pQE_C160S一 C2をプライマーとして用いることにより、 PCRを行な つた。 これにより增幅された断片を制限酵素 BamHIにより消化し、ァガロース電気 泳動により精製した後、 あらかじめ、制限酵素 BamHIにより消化し、それをアル力 リフォスファターゼ処理したプラスミ ド pQE82Lとライゲーシヨンし Escherichia coli DH5 α株を形質転換した。形質転換株よりプラスミドを単離し塩基配列解析を 行なうことにより、ァミノ末端にヒスチジンタグを持つ融合蛋白質として配列番号 3 8で表されるアミノ酸配列を有する UPRTaseを発現させる構造であることを確 認した。 このプラスミドを用いて Escherichia coli BL21株を形質転換し、 得られ た形質転換株を、 以下の UPRTase発現株として用いた。 なお、 C160Sの置換は、 酵 素の比活性にほとんど影響を与えなかった（データ示さず)。 PQE_C160S_Nl and pQE—C160S N2 having the base sequences represented by SEQ ID NOs: 3 and 4 and pQE—C160S one C1 and pQE_C160S_C2 having the base sequences represented by SEQ ID NOs: 3 and 3 and PCR was performed separately, and each product was purified by agarose electrophoresis. Subsequently, PCR was carried out by mixing them into a cage and using pQE_C160S_Nl and pQE_C160S-C2 as primers. The amplified fragment is digested with the restriction enzyme BamHI and purified by agarose electrophoresis, and then digested with the restriction enzyme BamHI in advance and ligated with the plasmid pQE82L treated with alfa phosphatase. Escherichia E. coli DH5α strain was transformed. By isolating the plasmid from the transformant and conducting base sequence analysis, it was confirmed that the UPRTase having the amino acid sequence represented by SEQ ID NO: 38 was expressed as a fusion protein having a histidine tag at the amino terminal. . Escherichia coli BL21 was transformed with this plasmid, and the resulting transformant was used as the following UPRTase expression strain. Substitution of C160S had little effect on the specific activity of the enzyme (data not shown).
【0 0 8 7】  [0 0 8 7]
2Lバッフル付きフラスコに入れた 50mg/Lアンピシリンを含む 250 mL の  250 mL containing 50 mg / L ampicillin in a 2 L baffled flask
Terrific培地 （12 g/L トリプトン、 24 g/L酵母エキス、 9. 4 g/L リン酸水素力 リウム、 2. 2 g/L リン酸 2水素カリウム、 4 mL/L グリセロール、 pH 7. 2に調整） に植菌し、 37°Cで 4時間培養した後、 0D660が約 2. 0になった時点で、最終濃度 1 mM となるよう IPTGを添加し、 引き続き 25°Cでさらに 12時間培養した。 得られた培 養液を遠心分離することにより集菌し、 沈澱した菌体を破碎緩衝液 (50 mM. Terrific medium (12 g / L tryptone, 24 g / L yeast extract, 9.4 g / L potassium hydrogen phosphate, 2.2 g / L potassium dihydrogen phosphate, 4 mL / L glycerol, pH 7.2 And then incubate at 37 ° C for 4 hours. When 0D660 reaches approximately 2.0, add IPTG to a final concentration of 1 mM, and continue at 25 ° C for another 12 hours. Cultured. The resulting culture solution was collected by centrifugation, and the precipitated cells were disrupted with a disruption buffer (50 mM.
Na- phosphate pH 7. 0、 300 IDM NaCl、 10 mM 2-メルカプトェタノール）に再懸濁し、 氷浴により冷却しながら超音波処理により菌体を破碎した。 これを- lOOOOrpmで一 時間遠心し上清に細胞抽出物を得た。 ヒスチジンタグ融合タンパク質の精製には TAL0Nレジン（Clonetech社製）を用いた。 50 mLの培養液あたり 200 ju Lの TAL0Nレ ジンを使用した。 洗浄緩衝液（50 mM Na- phosphate pH 7. 0、 15 mMィミダゾール、 10 mM 2-メルカプトエタノール）で洗浄した後、 溶出緩衝液 (50 mM Na- phosphate pH 7. 0、 150 mMイミダゾール、 10 mM 2-メルカプトエタノール）で溶出した。 以上の 操作は室温で行なった。 以下の操作は 4°Cで行なった。 この回収画分を陰イオンク ロマトグラフィ一の平衡化緩衝液（20 mM Tris-HCl， pH 8. 5)に対して 1晚透析した。 透析内液を lOOOOrpmの回転数で 10分間遠心分離'した後、上清画分のみを回収した。 陰ィオン交換力ラム（monoQカラム、 GEヘルスケアパイォサイエンス）に添カ卩した。 上記緩衝液により十分に平衡化した後、 波長 280nmでの UV吸収を指標に 0→0. 5M NaClの直線濃度勾配によって溶出した。 活性画分は 250〜350mM NaClの範囲に溶 出した。 この活性画分に、 0. 5 mM DTT、 0. 5 mM GTPの濃度となるよう、 ストック 溶液を添加した後、 amicon ultra- 15を用いて濃縮し、 さらに濃縮緩衝液 (20 mM Tris-HCl pH8. 5、 20 mM NaCl, 0. 5 mM DTT、 0. 5 mM GTP)を添加し、 もとの緩衝液 を交換しながら、 18 mg/mLの濃度まで濃縮した。 The suspension was resuspended in Na-phosphate pH 7.0, 300 IDM NaCl, 10 mM 2-mercaptoethanol, and the cells were disrupted by sonication while cooling in an ice bath. This was centrifuged at −lOOOOrpm for 1 hour to obtain a cell extract in the supernatant. TAL0N resin (manufactured by Clonetech) was used for purification of the histidine tag fusion protein. 200 juL of TAL0N resin was used per 50 mL of culture. After washing with wash buffer (50 mM Na-phosphate pH 7.0, 15 mM imidazole, 10 mM 2-mercaptoethanol), elution buffer (50 mM Na-phosphate pH 7.0, 150 mM imidazole, 10 mM Elution with 2-mercaptoethanol). The above operation was performed at room temperature. The following operations were performed at 4 ° C. The collected fraction was dialyzed against the anion chromatography equilibration buffer (20 mM Tris-HCl, pH 8.5) for 1 μm. The dialyzed internal solution was centrifuged at lOOOO rpm for 10 minutes, and then only the supernatant fraction was collected. Anion exchange capacity ram (monoQ column, GE Healthcare Pio Science) was added. After sufficiently equilibrating with the above buffer solution, elution was carried out with a linear concentration gradient of 0 → 0.5M NaCl using UV absorption at a wavelength of 280 nm as an index. The active fraction was dissolved in the range of 250 to 350 mM NaCl. To this active fraction, a stock solution was added to a concentration of 0.5 mM DTT and 0.5 mM GTP, and then concentrated using amicon ultra-15, and further concentrated buffer (20 mM Tris-HCl pH 8.5, 20 mM NaCl, 0.5 mM DTT, 0.5 mM GTP) was added, and the solution was concentrated to a concentration of 18 mg / mL while exchanging the original buffer.
【0 0 8 8】  [0 0 8 8]
< UPRTaseの X線結晶構造解析 > <X-ray crystal structure analysis of UPRTase>
シッティングドロップ蒸気拡散法により結晶化を行なった。上記で調製したリコ ンビナント UPRTase濃縮溶液と、 0. 2 mM di- ammonium tartrateおよび 15 - 20% (w/v) PEG3350を含む溶液とを等量ずつ混合し、約 1週間静置する事により、0. 05 X 0. 05 X 0. 15 mm3程度の柱状結晶が析出した。 【0 0 8 9】 Crystallization was performed by a sitting drop vapor diffusion method. By mixing equal amounts of the recombinant UPRTase concentrated solution prepared above and a solution containing 0.2 mM di-ammonium tartrate and 15-20% (w / v) PEG3350, and allowing to stand for about 1 week, Columnar crystals of about 0. 05 X 0. 05 X 0. 15 mm 3 were precipitated. [0 0 8 9]
高エネルギー加速器研究機構物質構造科学研究所放射光科学研究施設のビーム ライン BL5Aにおいて、 ADSC製 Quantum 315検出器を用いて X線回折データを収集 した。 波長は 1. 0000 Aに設定し、 結晶から検出器までの距離は 352. ½mに設定し た。測定温度は 100Kで行なった。 1フレーム当たり振動角 1° で 20秒間露光した。 CCP4パッケージのプログラム Mosflmを用いてデータを処理した結果、 Emergeの 値は、 100-2. 3 A分解能で 10. 8%、 最外殻シェルの 2. 42-2. 30 A分解能で 61. 1%とな つた。 データの完全性は、 100- 2. 3A分解能で 92. 9%、 最外殻シェルの 2. 42- 2. 30 A分解能で 89. 6%となった。 結晶は、 三方晶系に属し、 空間群 £3221、 格子定数 a=b=73. lA. £=279. 9A、 = =90. θΑ、 i=120. OAであった。 結晶の非対称単位 中には、 4分子の UPRTase分子が含まれ、 結晶の溶媒含有率は約 45%であった。 【0 0 9 0】 X-ray diffraction data was collected using the ADSC Quantum 315 detector at the beamline BL5A of the Institute for Materials Structure Science, High Energy Accelerator Research Organization. The wavelength was set to 1.0000 A and the distance from the crystal to the detector was set to 352.½ m. The measurement temperature was 100K. The exposure was performed for 20 seconds at a vibration angle of 1 ° per frame. As a result of processing data using the Mosflm program of the CCP4 package, the value of Emerge is 10.8% at 100-2. 3 A resolution, and 2.4.1-2.30 A resolution at the outermost shell is 61.1. %. The data integrity was 92.9% at 100-2.3A resolution and 89.6% at 2.42-2.30A resolution of the outermost shell. Crystals belong to trigonal space group £ 3 2 21, the lattice constants a = b = 73. LA. £ = 279. 9A, = = 90. ΘΑ, were i = 120. OA. The crystal asymmetric unit contained 4 UPRTase molecules, and the solvent content of the crystal was about 45%. [0 0 9 0]
<立体構造決定 > '  <Determination of 3D structure>
構造決定は、 Thermotoga maritima UPRTase (PDB code 1050) の単量体構造をサー チモデルとした分子置換法により行つた。 構造解析プログラムは MolRep (CCP package)を、 構造精密化プログラムは CNX (Accelrys社）を、 構造表示プログラム は Coot (CCP4 package)を、それぞれ用いた。繰り返し精密化作業を行い、水分子、 GTP分子を含む 2. 3 A分解能の精密化構造を決定し、 Rf actorは 21. 0% (Rfree 28. 3%) となった。 プログラム PR0CHECKを用いてラマチャンドラン.プロットを作製したと ころ、 グリシン以外の残基のうち、 90. 6%が最も好ましい領域に位置し、 全体の 99. 9%の残基が許容され得るぺプチド結合の二面角を有することが示された。 The structure was determined by a molecular replacement method using the monomer structure of Thermotoga maritima UPRTase (PDB code 1050) as a search model. The structural analysis program was MolRep (CCP package), the structural refinement program was CNX (Accelrys), and the structural display program was Coot (CCP4 package). After repetitive refinement, a 2.3 A resolution refined structure including water and GTP molecules was determined, and the Rf actor was 21.0% (Rfree 28.3%). When the Ramachandran plot was created using the program PR0CHECK, 90.6% of the non-glycine residues were located in the most preferred region, and 99.9% of the total residues were acceptable. It has been shown to have a dihedral angle of peptide bonds.
得られた三次元構造情報 （構造座標） を表 1に示す。 Table 1 shows the obtained three-dimensional structure information (structure coordinates).
【0 0 9 1】  [0 0 9 1]
【表 1】  【table 1】
CRYST1 73. 070 73. 070 279. 920 90. 00 90. 00 120； 00 P 32 2 1  CRYST1 73. 070 73. 070 279. 920 90. 00 90. 00 120; 00 P 32 2 1
ATOM 1 CB SER A 9 -34. 044 - 3. 317 -15. 005 1 . 00 66. 85 C ATOM 1 CB SER A 9 -34. 044-3. 317 -15. 005 1. 00 66. 85 C
ATOM 2 06 SER A 9 -34. 150 -2. 021 -15. 567 1. 00 67. 98 0ATOM 2 06 SER A 9 -34. 150 -2. 021 -15. 567 1. 00 67. 98 0
ATOM 3 C SER A 9 -35. 070 -4. 992 -13. 455 1. 00 65. 61 CATOM 3 C SER A 9 -35. 070 -4. 992 -13. 455 1. 00 65. 61 C
ATOM 4 0 SER A 9 -36. 1 18 -5. 637 -13. 357 1. 00 66. 62 0ATOM 4 0 SER A 9 -36. 1 18 -5. 637 -13. 357 1. 00 66. 62 0
ATOM 5 N SER A 9 - 34. 847 -2. 595 -12. 774 1 . 00 66. 45 NATOM 5 N SER A 9-34. 847 -2. 595 -12. 774 1. 00 66. 45 N
ATOM 6 CA SER A 9 -35. 094 -3. 531 - 13. 908 1 . 00 66. 28 CATOM 6 CA SER A 9 -35. 094 -3. 531-13. 908 1. 00 66. 28 C
ATOM 7 N MET A 10 - 33. 877 - 5. 509 -13. 177 1 . , 00 63. 16 NATOM 7 N MET A 10-33. 877-5. 509 -13. 177 1., 00 63. 16 N
ATOM 8 CA MET A 10 -33. 726 -6. 907 -12. 790 1 . . 00 60. 56 CATOM 8 CA MET A 10 -33. 726 -6. 907 -12. 790 1.. 00 60. 56 C
ATOM 9 CB MET A 10 - 32. 245 -7. 306 -12. 806 1 . , 00 65. 40 CATOM 9 CB MET A 10-32. 245 -7. 306 -12. 806 1., 00 65. 40 C
ATOM 10 CG MET A 10 -31. 731 -7. 769 -14. 176 1. , 00 69. 91 CATOM 10 CG MET A 10 -31. 731 -7. 769 -14. 176 1., 00 69. 91 C
ATOM 1 1 SD MET A 10 一 32. 514 -9. 303 -14. 784 1. , 00 75. 03 S ATOM 12 CE MET A 10 -31.081 -10.203 -15.451 1.00 73.23 CATOM 1 1 SD MET A 10 1 32. 514 -9. 303 -14. 784 1., 00 75. 03 S ATOM 12 CE MET A 10 -31.081 -10.203 -15.451 1.00 73.23 C
ATOM 13 C MET A 10 -34.332 -7.197 -11.419 1. 00 56.40 CATOM 13 C MET A 10 -34.332 -7.197 -11.419 1. 00 56.40 C
ATOM 14 0 MET A 10 -34.450 -6.310 -10.571 1. 00 54.73 0ATOM 14 0 MET A 10 -34.450 -6.310 -10.571 1. 00 54.73 0
ATOM 15 N LYS A 11 -34.711 -8.453 -11.212 1. 00 51.72 NATOM 15 N LYS A 11 -34.711 -8.453 -11.212 1. 00 51.72 N
ATOM 16 CA LYS A 11 - 35.626 -8.812 -10.137 1. 00 46.71 CATOM 16 CA LYS A 11-35.626 -8.812 -10.137 1. 00 46.71 C
ATOM 17 CB LYS A 11 - 36.390 - 10.087 -10.516 1. 00 46.56 CATOM 17 CB LYS A 11-36.390-10.087 -10.516 1. 00 46.56 C
ATOM 18 CG LYS A 11 -35.491 -11.278 -10.820 1. 00 48.22 CATOM 18 CG LYS A 11 -35.491 -11.278 -10.820 1. 00 48.22 C
ATOM 19 CD LYS A 11 -36.254 -12.430 -11.461 1. 00 48.86 CATOM 19 CD LYS A 11 -36.254 -12.430 -11.461 1.00 48.86 C
ATOM 20 CE LYS A 11 -37.453 - 12.844 - 10.621 1. 00 51.11 - CATOM 20 CE LYS A 11 -37.453-12.844-10.621 1.00 51.11-C
ATOM 21 NZ LYS A 11 -37.918 -14.228 -10.932 1. 00 49.91 NATOM 21 NZ LYS A 11 -37.918 -14.228 -10.932 1. 00 49.91 N
ATOM 22 C LYS A 11 -34.953 -8.991 -8.775 1. 00 42.84 CATOM 22 C LYS A 11 -34.953 -8.991 -8.775 1. 00 42.84 C
ATOM 23 0 LYS A 11 -33.764 -9.282 -8.683 1. 00 42.47 0ATOM 23 0 LYS A 11 -33.764 -9.282 -8.683 1.00 42.47 0
ATOM 24 N ILE A 12 - 35.737 - 8.803 -7.721 1. 00 38.51 ― NATOM 24 N ILE A 12-35.737-8.803 -7.721 1. 00 38.51 ― N
ATOM 25 CA ILE A 12 -35.288 -9.021 - 6.356 1. 00 33.33 CATOM 25 CA ILE A 12 -35.288 -9.021-6.356 1. 00 33.33 C
ATOM 26 CB ILE A 12 - 35.548 -7.787 -5.489 1 00 33.72 CATOM 26 CB ILE A 12-35.548 -7.787 -5.489 1 00 33.72 C
ATOM 27 CG2 ILE A 12 -35.063 -8.037 -4.063 1 00 32.91 CATOM 27 CG2 ILE A 12 -35.063 -8.037 -4.063 1 00 32.91 C
ATOM 28 CG1 ILE A 12 -34.869 -6.565 - 6.119 1 00 33.27 CATOM 28 CG1 ILE A 12 -34.869 -6.565-6.119 1 00 33.27 C
ATOM 29 CD1 ILE A 12 - 33.393 -6.734 -6.362 1 00 28.87 CATOM 29 CD1 ILE A 12-33.393 -6.734 -6.362 1 00 28.87 C
ATOM 30 C ILE A 12 -36.105 -10.170 -5.802 1 00 31.87 CATOM 30 C ILE A 12 -36.105 -10.170 -5.802 1 00 31.87 C
ATOM 31 0 ILE A 12 -37.321 -10.079 -5.708 1 00 33.59 0ATOM 31 0 ILE A 12 -37.321 -10.079 -5.708 1 00 33.59 0
ATOM 32 N VAL A 13 -35.440 -11.255 - 5.438 1 00 29.14 NATOM 32 N VAL A 13 -35.440 -11.255-5.438 1 00 29.14 N
ATOM 33 CA VAL A 13 -36.146 -12.480 -5.122 1 00 26.47 CATOM 33 CA VAL A 13 -36.146 -12.480 -5.122 1 00 26.47 C
ATOM 34 CB VAL A 13 -35.810 -13.588 -6.134 1 00 26.36 CATOM 34 CB VAL A 13 -35.810 -13.588 -6.134 1 00 26.36 C
ATOM 35 C61 VAL A 13 -36.615一 14.844 - 5.809 1 00 26.34 CATOM 35 C61 VAL A 13 -36.615 One 14.844-5.809 1 00 26.34 C
ATOM 36 CG2 VAL A 13 36· 093 -13.104 -7, 546 1 00 24.84 CATOM 36 CG2 VAL A 13 36 093 -13.104 -7, 546 1 00 24.84 C
ATOM 37 C VAL A 13 -35.811 - 12.985 -3.727 1 00 27.03 CATOM 37 C VAL A 13 -35.811-12.985 -3.727 1 00 27.03 C
ATOM 38 0 VAL A 13 -34.647 -13.222 -3.396 1 00 27.91 0ATOM 38 0 VAL A 13 -34.647 -13.222 -3.396 1 00 27.91 0
ATOM 39 N 6LU A 14 -36.848 -13.144 -2.917 1 00 26.13 NATOM 39 N 6LU A 14 -36.848 -13.144 -2.917 1 00 26.13 N
ATOM 40 CA GLU A 14 -36.722 -13.755 -1.614 1 00 27.49 CATOM 40 CA GLU A 14 -36.722 -13.755 -1.614 1 00 27.49 C
ATOM 41 CB GLU A 14 -37.532 -12.966 -0.594 1 00 28.68 CATOM 41 CB GLU A 14 -37.532 -12.966 -0.594 1 00 28.68 C
ATOM 42 CG GLU A 14 -37.378 -13.455 0.823 1 00 34.43 CATOM 42 CG GLU A 14 -37.378 -13.455 0.823 1 00 34.43 C
ATOM 43 CD GLU A 14 -38.270 -12.706 1.802 1 00 37.94 CATOM 43 CD GLU A 14 -38.270 -12.706 1.802 1 00 37.94 C
ATOM 44 0E1 GLU A 14 - 37.860 -12.555 2.972 1 00 41.56 0ATOM 44 0E1 GLU A 14-37.860 -12.555 2.972 1 00 41.56 0
ATOM 45 0E2 GLU A 14 -39.376 -12.270 1.407 1 00 39.25 0ATOM 45 0E2 GLU A 14 -39.376 -12.270 1.407 1 00 39.25 0
ATOM 46 C GLU A 14 -37.282 —15.161 -1.750 1 00 27.92 CATOM 46 C GLU A 14 -37.282 —15.161 -1.750 1 00 27.92 C
ATOM 47 0 GLU A 14 -38.492 -15.339 -1.877 1 00 29.59 0 ATOM 48 N VAL A 15 -36.402 - 16.155 -1.735 1.00 26.38 ΝATOM 47 0 GLU A 14 -38.492 -15.339 -1.877 1 00 29.59 0 ATOM 48 N VAL A 15 -36.402-16.155 -1.735 1.00 26.38 Ν
ATOM 49 CA VAL A 15 - 36.809 -17.526 - 2.008 1. 00 26.73 CATOM 49 CA VAL A 15-36.809 -17.526-2.008 1. 00 26.73 C
ATOM 50 CB VAL A 15 -35.597 -18.403 - 2.328 1. 00 25.34 CATOM 50 CB VAL A 15 -35.597 -18.403-2.328 1. 00 25.34 C
ATOM 51 C61 VAL A 15 -36.048 -19.843 -2.584 1. 00 22.63 CATOM 51 C61 VAL A 15 -36.048 -19.843 -2.584 1.00 22.63 C
ATOM 52 C62 VAL A 15 -34.858 -17.832 - 3.525 1. 00 17.75 CATOM 52 C62 VAL A 15 -34.858 -17.832-3.525 1. 00 17.75 C
ATOM 53 C VAL A 15 - 37, 532 -18.113 -0.810 1. 00 29.31 CATOM 53 C VAL A 15-37, 532 -18.113 -0.810 1. 00 29.31 C
ATOM 54 0 VAL A 15 -36.973 - 18.185 0.278 1. 00 31. 55 0ATOM 54 0 VAL A 15 -36.973-18.185 0.278 1. 00 31. 55 0
ATOM 55 N LYS A 16 -38.775 -18.535 -1.018 1. 00 31. 23 ΝATOM 55 N LYS A 16 -38.775 -18.535 -1.018 1. 00 31. 23 Ν
ATOM 56 CA LYS A 16 -39, 662 -18.894 0.082 1. 00 33.06 CATOM 56 CA LYS A 16 -39, 662 -18.894 0.082 1. 00 33.06 C
ATOM 57 CB LYS A 16 -40.984 -18.131 -0.036 1. 00 36.09 CATOM 57 CB LYS A 16 -40.984 -18.131 -0.036 1. 00 36.09 C
ATOM 58 C6 LYS A 16 -40.823 -16.621 0.090 1. 00 40.91 CATOM 58 C6 LYS A 16 -40.823 -16.621 0.090 1.00 40.91 C
ATOM 59 CD LYS A 16 -42.166 -15.912 0.201 1. 00 43. 84 CATOM 59 CD LYS A 16 -42.166 -15.912 0.201 1. 00 43. 84 C
ATOM 60 CE LYS A 16 一 41. 977 -14.482 0.686 1. 00 44. 33 . GATOM 60 CE LYS A 16 1 41. 977 -14.482 0.686 1. 00 44. 33.
ATOM 61 NZ LYS A 16 -41. 179 -14.454 1. 00 46. 70 ΝATOM 61 NZ LYS A 16 -41. 179 -14.454 1. 00 46. 70 Ν
ATOM 62 C LYS A 16 -39. 942 -20.381 0.132 1. 00 33. 21 CATOM 62 C LYS A 16 -39. 942 -20.381 0.132 1. 00 33. 21 C
ATOM 63 0 LYS A 16 -40. 844 0.847 1. 00 33. 99 0ATOM 63 0 LYS A 16 -40. 844 0.847 1. 00 33. 99 0
ATOM 64 N HIS A 17 -39. 177 -21.145 -0.640 1. 00 30. 86 ΝATOM 64 N HIS A 17 -39. 177 -21.145 -0.640 1. 00 30. 86 Ν
ATOM 65 CA HIS A 17 一 39. 227 - 22.594 - 0.550 1. ,00 28. 67 CATOM 65 CA HIS A 17 39. 227-22.594-0.550 1., 00 28. 67 C
ATOM 66 CB HIS A 17 -38. 085 -23.208 -1.369 1. 00 26. 77 GATOM 66 CB HIS A 17 -38. 085 -23.208 -1.369 1. 00 26. 77 G
ATOM 67 C6 HIS A 17 -38. 222 -24.682 -1■ 584 1. .00 27. 84 CATOM 67 C6 HIS A 17 -38. 222 -24.682 -1 584 1. .00 27. 84 C
ATOM 68 CD2 HIS A 17 -38. 599 -25.392 -2.674 1. ,00 29. 19 CATOM 68 CD2 HIS A 17 -38. 599 -25.392 -2.674 1., 00 29. 19 C
ATOM 69 ND1 HIS A 17 一 37. 976 -25.607 -0.591 1. ,00 26. 79 ΝATOM 69 ND1 HIS A 17 1 37. 976 -25.607 -0.591 1., 00 26. 79 Ν
ATOM 70 CE1 HIS A 17 -38. 197 -26.823 - 1.059 1. ,00 28. 21 CATOM 70 CE1 HIS A 17 -38. 197 -26.823-1.059 1., 00 28. 21 C
ATOM 71 NE2 HIS A 17 -38. 575 -26.721 - 2.321 1. .00 29. 39 ΝATOM 71 NE2 HIS A 17 -38. 575 -26.721-2.321 1. .00 29. 39 Ν
ATOM 72 C HIS A 17 -39. 079 -22.959 0.923 1. .00 27. 92 CATOM 72 C HIS A 17 -39. 079 -22.959 0.923 1. .00 27. 92 C
ATOM 73 0 HIS A 17 -38. 261 -22.386 1.629 1. .00 29. 37 0ATOM 73 0 HIS A 17 -38. 261 -22.386 1.629 1. .00 29. 37 0
ATOM 74 N PRO A 18 - 39. 881 -23.911 1.406 1. ,00 27. 95 ΝATOM 74 N PRO A 18-39. 881 -23.911 1.406 1., 00 27. 95 Ν
ATOM 75 CD PRO A 18 -40. 840 -24.715 0.629 1, .00 27. 86 CATOM 75 CD PRO A 18 -40. 840 -24.715 0.629 1, .00 27. 86 C
ATOM 76 CA PRO A 18 - 39. 886 - 24.253 2.833 1, .00 27. 17 CATOM 76 CA PRO A 18-39. 886-24.253 2.833 1, .00 27. 17 C
ATOM 77 CB PRO A 18 -41. 046 -25.247 2.967 1. .00 27. 37 CATOM 77 CB PRO A 18 -41. 046 -25.247 2.967 1. .00 27. 37 C
ATOM 78 CG PRO A 18 -41. 232 -25.810 1.587 1, .00 29. 66 CATOM 78 CG PRO A 18 -41. 232 -25.810 1.587 1, .00 29. 66 C
ATOM 79 C PRO A 18 - 38. 563 - 24.824 3.359 1, .00 26. 55 CATOM 79 C PRO A 18-38. 563-24.824 3.359 1, .00 26. 55 C
ATOM 80 0 PRO A 18 -38. 232 -24.656 4.534 1, .00 23. 49 0ATOM 80 0 PRO A 18 -38. 232 -24.656 4.534 1, .00 23. 49 0
ATOM 81 N LEU A 19 -37. 806 -25.493 2.497 1 .00 25. 65 ΝATOM 81 N LEU A 19 -37. 806 -25.493 2.497 1 .00 25. 65 Ν
ATOM 82 CA LEU A 19 -36. 508 -26.020 2.909 1 .00 26. 07 CATOM 82 CA LEU A 19 -36. 508 -26.020 2.909 1 .00 26. 07 C
ATOM 83 CB LEU A 19 -35. 971 -27.011 1.865 1 .00 26. 33 C ATOM 84 CG LEU A 19 -36.604 -28.407 1.826 1.00 25.34 CATOM 83 CB LEU A 19 -35. 971 -27.011 1.865 1 .00 26. 33 C ATOM 84 CG LEU A 19 -36.604 -28.407 1.826 1.00 25.34 C
ATOM 85 CD1 LEU A 19 -35.913 -29.247 0.772 1. 00 27.70 CATOM 85 CD1 LEU A 19 -35.913 -29.247 0.772 1. 00 27.70 C
ATOM 86 CD2 LEU A 19 -36.477 -29.081 3.182 1. 00 27.47 CATOM 86 CD2 LEU A 19 -36.477 -29.081 3.182 1. 00 27.47 C
ATOM 87 C LEU A 19 -35.483 -24.904 3.149 1. 00 25.58 CATOM 87 C LEU A 19 -35.483 -24.904 3.149 1. 00 25.58 C
ATOM 88 0 LEU A 19 -34.666 - 24.994 4.064 1. 00 27.49 0ATOM 88 0 LEU A 19 -34.666-24.994 4.064 1.00 27.49 0
ATOM 89 N VAL A 20 -35.519 - 23.853 2.341 1. 00 23.51 NATOM 89 N VAL A 20 -35.519-23.853 2.341 1. 00 23.51 N
ATOM 90 CA VAL A 20 -34.612 -22.742 2.576 1. 00 25.20 CATOM 90 CA VAL A 20 -34.612 -22.742 2.576 1. 00 25.20 C
ATOM 91 CB VAL A 20 -34.477 -21.814 1.319 1. 00 24.62 CATOM 91 CB VAL A 20 -34.477 -21.814 1.319 1. 00 24.62 C
ATOM 92 C61 VAL A 20 -35.568 - 22.102 0.332 1. 00 26.26 CATOM 92 C61 VAL A 20 -35.568-22.102 0.332 1. 00 26.26 C
ATOM 93 C62 VAL A 20 - 34.505 -20.350 1.728 1. 00 19.98 CATOM 93 C62 VAL A 20-34.505 -20.350 1.728 1. 00 19.98 C
ATOM 94 C VAL A 20 -35.042 - 21.952 3.806 1 00 25.46 CATOM 94 C VAL A 20 -35.042-21.952 3.806 1 00 25.46 C
ATOM . 95 0 VAL A 20 - 34.210 -21.591 4.633 1. 00 24.84 0ATOM. 95 0 VAL A 20-34.210 -21.591 4.633 1. 00 24.84 0
ATOM 96 N LYS A 21 - 36.343 -21.721 3.955 1 00 28.32 NATOM 96 N LYS A 21-36.343 -21.721 3.955 1 00 28.32 N
ATOM 97 CA LYS A 21 -36.859 5.185 1 00 28.23 CATOM 97 CA LYS A 21 -36.859 5.185 1 00 28.23 C
ATOM 98 CB LYS A 21 -38.392 -21.016 5.138 1 00 30.69 CATOM 98 CB LYS A 21 -38.392 -21.016 5.138 1 00 30.69 C
ATOM 99 CG LYS A 21 -38.906 - 20.100 4.036 1 00 34.86 CATOM 99 CG LYS A 21 -38.906-20.100 4.036 1 00 34.86 C
ATOM 100 CD LYS A 21 - 40.171 -19.346 4.437 1 00 37.12 CATOM 100 CD LYS A 21-40.171 -19.346 4.437 1 00 37.12 C
ATOM 101 CE LYS A 21 -41.380 -20.260 4.535 1 00 39.15 CATOM 101 CE LYS A 21 -41.380 -20.260 4.535 1 00 39.15 C
ATOM 102 NZ LYS A 21 -42.638 -19.483 4.733 1 00 40.67 NATOM 102 NZ LYS A 21 -42.638 -19.483 4.733 1 00 40.67 N
ATOM 103 C LYS A 21 -36.438 -21.926 6.410 1 00 26.02 CATOM 103 C LYS A 21 -36.438 -21.926 6.410 1 00 26.02 C
ATOM 104 0 LYS A 21 -35.993 -21 · 360 7.406 1 00 25.59 0ATOM 104 0 LYS A 21 -35.993 -21 360 7.406 1 00 25.59 0
ATOM 105 N HIS A 22 - 36.576 -23.249 6.326 1 00 24.31 NATOM 105 N HIS A 22-36.576 -23.249 6.326 1 00 24.31 N
ATOM 106 CA HIS A 22 - 36.219 -24.149 7.424 1 00 22.67 CATOM 106 CA HIS A 22-36.219 -24.149 7.424 1 00 22.67 C
ATOM 107 CB HIS A 22 -36.640 -25.580 7.067 1 00 23.43 CATOM 107 CB HIS A 22 -36.640 -25.580 7.067 1 00 23.43 C
ATOM 108 CG HIS A 22 -36.058 -26.629 7.963 1 00 23.83 CATOM 108 CG HIS A 22 -36.058 -26.629 7.963 1 00 23.83 C
ATOM 109 CD2 HIS A 22 -34.938 -27.384 7.842 1 00 24.24 CATOM 109 CD2 HIS A 22 -34.938 -27.384 7.842 1 00 24.24 C
ATOM 110 ND1 HIS A 22 -36.656 -27.017 9.143 1 00 25.24 . NATOM 110 ND1 HIS A 22 -36.656 -27.017 9.143 1 00 25.24 .N
ATOM 111 CE1 HIS A 22 -35.932 -27.967 9.711 1 00 25.59 CATOM 111 CE1 HIS A 22 -35.932 -27.967 9.711 1 00 25.59 C
ATOM 112 NE2 HIS A 22 -34.882 - 28.208 8.942 1 00 25.67 NATOM 112 NE2 HIS A 22 -34.882-28.208 8.942 1 00 25.67 N
ATOM 113 C HIS A 22 -34.727 -24.114 7.771 1 00 23.98 CATOM 113 C HIS A 22 -34.727 -24.114 7.771 1 00 23.98 C
ATOM 114 0 HIS A 22 -34.354 -23.976 8.939 1 00 23.83 0ATOM 114 0 HIS A 22 -34.354 -23.976 8.939 1 00 23.83 0
ATOM 115 N LYS A 23 -33.874 -24.237 6.755 1 00 22.96 NATOM 115 N LYS A 23 -33.874 -24.237 6.755 1 00 22.96 N
ATOM 116 CA LYS A 23 -32.433 -24.240 6.969 1 00 22.05 CATOM 116 CA LYS A 23 -32.433 -24.240 6.969 1 00 22.05 C
ATOM 117 CB LYS A 23 -31.717 -24.629 5.674 1 00 21.23 CATOM 117 CB LYS A 23 -31.717 -24.629 5.674 1 00 21.23 C
ATOM 118 CG LYS A 23 -31.957 - 26.068 5.251 1 00 17.07 CATOM 118 CG LYS A 23 -31.957-26.068 5.251 1 00 17.07 C
ATOM 119 CD LYS A 23 -31.456 —26.329 3.847 1 .00 18.25 C ATOM 120 CE LYS A 23 -31.902 -27.687 3.329 1.00 16.73 CATOM 119 CD LYS A 23 -31.456 —26.329 3.847 1 .00 18.25 C ATOM 120 CE LYS A 23 -31.902 -27.687 3.329 1.00 16.73 C
ATOM 121 NZ LYS A 23 -31 · 365 -28.826 4.128 1. 00 19.63 NATOM 121 NZ LYS A 23 -31 365 -28.826 4.128 1. 00 19.63 N
ATOM 122 C LYS A 23 -31.936 - 22.878 7.456 1. 00 22.50 CATOM 122 C LYS A 23 -31.936-22.878 7.456 1. 00 22.50 C
ATOM 123 0 LYS A 23 - 31.094 -22.797 8.345 1. 00 20.22 0ATOM 123 0 LYS A 23-31.094 -22.797 8.345 1. 00 20.22 0
ATOM 124 N LEU A 24 -32.470 - 21. 808 6.880 1. 00 22.96 NATOM 124 N LEU A 24 -32.470-21.808 6.880 1.00 22.96 N
ATOM 125 CA LEU A 24 -32.087 - 20.463 7. 290 1. 00 25.94 CATOM 125 CA LEU A 24 -32.087-20.463 7. 290 1. 00 25.94 C
ATOM 126 CB LEU A 24 -32.797 -19.438 6.400 1. 00 25.48 CATOM 126 CB LEU A 24 -32.797 -19.438 6.400 1. 00 25.48 C
ATOM 127 GG LEU A 24 -32.338 -17.977 6. 394 1. 00 27.81 CATOM 127 GG LEU A 24 -32.338 -17.977 6. 394 1.00 27.81 C
ATOM 128 CD1 LEU A 24 -33.086 -17.191 7. 452 1. 00 27.75 CATOM 128 CD1 LEU A 24 -33.086 -17.191 7. 452 1. 00 27.75 C
ATOM 129 CD2 LEU A 24 -30.835 -17. 912 6. 617 1. 00 25. 34 CATOM 129 CD2 LEU A 24 -30.835 -17. 912 6. 617 1. 00 25. 34 C
ATOM 130 C LEU A 24 -32.477 - 20. 269 8. 765 1. 00 28. 02 CATOM 130 C LEU A 24 -32.477-20. 269 8. 765 1. 00 28. 02 C
ATOM 131 .0 LEU A 24 -19. 808 9. 582 1. 00 28. 48 0ATOM 131 .0 LEU A 24 -19. 808 9. 582 1. 00 28. 48 0
ATOM 132 N GLY A 25 -33.698 - 20. 655 9. 104 1. 00 27. 71 . NATOM 132 N GLY A 25 -33.698-20. 655 9. 104 1. 00 27. 71 .N
ATOM 133 CA GLY A 25 - 34.141 - 20. 533 10. 476 1. 00 30. 19 CATOM 133 CA GLY A 25-34.141-20. 533 10. 476 1. 00 30. 19 C
ATOM 134 C GLY A 25 -33.188 - 21. 185 11. 457 1. 00 31. 64 CATOM 134 C GLY A 25 -33.188-21. 185 11. 457 1. 00 31. 64 C
ATOM 135 0 GLY A 25 -32.903 -20. 621 12. 514 1. 00 33. 32 0ATOM 135 0 GLY A 25 -32.903 -20. 621 12. 514 1. 00 33. 32 0
ATOM 136 N LEU A 26 -32.690 -22. 372 11. 120 1. 00 29. 82 NATOM 136 N LEU A 26 -32.690 -22. 372 11. 120 1. 00 29. 82 N
ATOM 137 CA LEU A 26 -31.733 -23. 039 11. 988 1. ,00 28. 07 CATOM 137 CA LEU A 26 -31.733 -23. 039 11. 988 1., 00 28. 07 C
ATOM 138 CB LEU A 26 -31.368 -24. 409 11. 423 1. 00 26. 52 CATOM 138 CB LEU A 26 -31.368 -24. 409 11. 423 1. 00 26. 52 C
ATOM 139 CG LEU A 26 -32. 30 - 25. 487 11. 682 1. 00 30. 28 CATOM 139 CG LEU A 26 -32. 30-25. 487 11. 682 1. 00 30. 28 C
ATOM 140 CD1 LEU A 26 -32.042 - 26. 792 11. 003 1. ,00 29. 22 CATOM 140 CD1 LEU A 26 -32.042-26. 792 11. 003 1., 00 29. 22 C
ATOM 141 CD2 LEU A 26 -32.585 - 25. 695 13. 181 1. 00 28. 84 CATOM 141 CD2 LEU A 26 -32.585-25. 695 13. 181 1. 00 28. 84 C
ATOM 142 C LEU A 26 -30.470 -22. 198 12. 186 1. ,00 27. 35 CATOM 142 C LEU A 26 -30.470 -22. 198 12. 186 1., 00 27. 35 C
ATOM 143 0 LEU A 26 -29.850 -22. 248 13. 243 1. ,00 27. 20 0ATOM 143 0 LEU A 26 -29.850 -22. 248 13. 243 1., 00 27. 20 0
ATOM 144 N MET A 27 - 30.104 - 21. 412 11. 、178 1. ,00 24. 38 NATOM 144 N MET A 27-30.104-21. 412 11., 178 1., 00 24. 38 N
ATOM 145 CA MET A 27 -28.859 - 20. 655 11. 222 1. ,00 25. 36 CATOM 145 CA MET A 27 -28.859-20. 655 11. 222 1., 00 25. 36 C
ATOM 146 CB MET A 27 - 28.521 -20. 103 9. 827 1. .00 23. 36 CATOM 146 CB MET A 27-28.521 -20. 103 9. 827 1. .00 23. 36 C
ATOM 147 CG MET A 27 -28.199 - 21. 183 8. 791 1. ,00 18. 23 CATOM 147 CG MET A 27 -28.199-21. 183 8. 791 1., 00 18. 23 C
ATOM 148 SD MET A 27 -27.430 - 20. 548 7. 276 1. .00 22. 40 SATOM 148 SD MET A 27 -27.430-20. 548 7. 276 1. .00 22. 40 S
ATOM 149 CE MET A 27 -25.923 -19. 803 7. 909 1. .00 21. 46 CATOM 149 CE MET A 27 -25.923 -19. 803 7. 909 1. .00 21. 46 C
ATOM 150 C MET A 27 - 28.922 -19. 512 12. 239 1, ■ 00 27. 00 CATOM 150 C MET A 27-28.922 -19. 512 12. 239 1, ∎ 00 27. 00 C
ATOM 151 0 MET A 27 - 27.892 - 19. 010 12. 683 1. .00 27. 22 0ATOM 151 0 MET A 27-27.892-19. 010 12. 683 1. .00 27. 22 0
ATOM 152 N ARG A 28 -30.133 -19. 114 12. 618 1, .00 26. 65 NATOM 152 N ARG A 28 -30.133 -19. 114 12. 618 1, .00 26. 65 N
ATOM 153 CA ARG A 28 - 30.306 - 18. 026 13. 565 1, .00 28. 26 CATOM 153 CA ARG A 28-30.306-18. 026 13. 565 1, .00 28. 26 C
ATOM 154 CB ARG A 28 -31.704 -17. 420 13. 421 1, .00 27. 33 CATOM 154 CB ARG A 28 -31.704 -17. 420 13. 421 1, .00 27. 33 C
ATOM 155 CG ARG A 28 -32.011 -16. 882 12. 027 1, .00 25. 78 C ATOM 156 CD ARG A 28 -33.293 -16.091 12.055 1.00 28.18 CATOM 155 CG ARG A 28 -32.011 -16. 882 12. 027 1, .00 25. 78 C ATOM 156 CD ARG A 28 -33.293 -16.091 12.055 1.00 28.18 C
ATOM 157 NE ARG A 28 -33.840 -15.777 10.737 1. 00 28.41 NATOM 157 NE ARG A 28 -33.840 -15.777 10.737 1. 00 28.41 N
ATOM 158 CZ ARG A 28 -33.552 -14.681 10.043 1. 00 29.58 CATOM 158 CZ ARG A 28 -33.552 -14.681 10.043 1. 00 29.58 C
ATOM 159 NH1 ARG A 28 -32.701 -13.786 10.529 1. 00 30.37 NATOM 159 NH1 ARG A 28 -32.701 -13.786 10.529 1. 00 30.37 N
ATOM 160 NH2 ARG A 28 -34.157 -14.453 8.885 1. 00 28.33 NATOM 160 NH2 ARG A 28 -34.157 -14.453 8.885 1. 00 28.33 N
ATOM 161 C ARG A 28 - 30.068 -18.457 15.015 1. 00 29.26 CATOM 161 C ARG A 28-30.068 -18.457 15.015 1. 00 29.26 C
ATOM 162 0 ARG A 28 -29.872 -17.618 15.891 1. 00 29.38 0ATOM 162 0 ARG A 28 -29.872 -17.618 15.891 1. 00 29.38 0
ATOM 163 N GLU A 29 - 30.068 -19.760 15.268 1. 00 30.96 NATOM 163 N GLU A 29-30.068 -19.760 15.268 1. 00 30.96 N
ATOM 164 CA GLU A 29 -29.848 -20.262 16.622 1. 00 34.86 CATOM 164 CA GLU A 29 -29.848 -20.262 16.622 1. 00 34.86 C
ATOM 165 CB GLU A 29 -29.750 -21 · 786 16.598 1. 00 37.21 CATOM 165 CB GLU A 29 -29.750 -21 786 16.598 1. 00 37.21 C
ATOM 166 GG GLU A 29 - 29.549 - 22.421 17.962 1. 00 44.44 CATOM 166 GG GLU A 29-29.549-22.421 17.962 1. 00 44.44 C
ATOM 167 CD GLU A 29 -30.808一 22.395 18.813 1. 00 49.95 CATOM 167 CD GLU A 29 -30.808 1 22.395 18.813 1. 00 49.95 C
ATOM 168 0E1 GLU A 29 -31.741 - 23.189 18.540 1. 00 51.74 0ATOM 168 0E1 GLU A 29 -31.741-23.189 18.540 1. 00 51.74 0
ATOM 169 0E2 GLU A 29 -30.863 -21.580 19.760 1. 00 54.07 0ATOM 169 0E2 GLU A 29 -30.863 -21.580 19.760 1. 00 54.07 0
ATOM 170 C GLU A 29 - 28.587 -19.664 17.265 1. 00 35.79 CATOM 170 C GLU A 29-28.587 -19.664 17.265 1. 00 35.79 C
ATOM 171 0 GLU A 29 -27.508一 19.664 16.668 1. 00 36.07 0ATOM 171 0 GLU A 29 -27.508 One 19.664 16.668 1. 00 36.07 0
ATOM 172 N 6LN A 30 -28.722 -19.164 18.489 1. 00 36.81 NATOM 172 N 6LN A 30 -28.722 -19.164 18.489 1. 00 36.81 N
ATOM 173 CA GLN A 30 - 27.652 -18.383 19.097 1. ,00 39.04 CATOM 173 CA GLN A 30-27.652 -18.383 19.097 1., 00 39.04 C
ATOM 174 CB GLN A 30 -28.148 -17.692 20.372 1. ,00 41.76 CATOM 174 CB GLN A 30 -28.148 -17.692 20.372 1., 00 41.76 C
ATOM 175 CG GLN A 30 -27.840 -18.440 21.658 1. .00 42.72 CATOM 175 CG GLN A 30 -27.840 -18.440 21.658 1. .00 42.72 C
ATOM 176 CD GLN A 30 -26.508 - 18.036 22.265 1. ,00 43.26 CATOM 176 CD GLN A 30 -26.508-18.036 22.265 1., 00 43.26 C
ATOM 177 0E1 GLN A 30 -25.927 -17.013 21.898 1. ,00 41.96 0ATOM 177 0E1 GLN A 30 -25.927 -17.013 21.898 1., 00 41.96 0
ATOM 178 NE2 GLN A 30 -26.018 -18.842 23.201 1. .00 43.03 NATOM 178 NE2 GLN A 30 -26.018 -18.842 23.201 1. .00 43.03 N
ATOM 179 C GLN A 30 -26.433 -19.229 19.426 1. .00 40.09 CATOM 179 C GLN A 30 -26.433 -19.229 19.426 1. .00 40.09 C
ATOM 180 0 GLN A 30 -25.302 -18.754 19.358 1, .00 41.19 0ATOM 180 0 GLN A 30 -25.302 -18.754 19.358 1, .00 41.19 0
ATOM 181 N ASP A 31 - 26.656 -20.485 19.783 1. .00 39.00 NATOM 181 N ASP A 31-26.656 -20.485 19.783 1. .00 39.00 N
ATOM 182 CA ASP A 31 -25.558 -21.321 20.225 1, .00 39.44 CATOM 182 CA ASP A 31 -25.558 -21.321 20.225 1, .00 39.44 C
ATOM 183 CB ASP A 31 -25.954 -22.088 21.480 1. .00 43.20 CATOM 183 CB ASP A 31 -25.954 -22.088 21.480 1. .00 43.20 C
ATOM 184 CG ASP A 31 -27.002 -23.142 21.201 1, .00 46.74 CATOM 184 CG ASP A 31 -27.002 -23.142 21.201 1, .00 46.74 C
ATOM 185 0D1 ASP A 31 -28.044 -22.785 20.610 1, .00 50.18 0ATOM 185 0D1 ASP A 31 -28.044 -22.785 20.610 1, .00 50.18 0
ATOM 186 0D2 ASP A 31 - 26.785 -24.321 21.564 1 .00 47.85 0ATOM 186 0D2 ASP A 31-26.785 -24.321 21.564 1 .00 47.85 0
ATOM 187 C ASP A 31 - 25.165 -22.313 19.147 1 .00 37.84 CATOM 187 C ASP A 31-25.165 -22.313 19.147 1 .00 37.84 C
ATOM 188 0 ASP A 31 -24.748 -23.430 19.450 1 ■ 00 39.99 0ATOM 188 0 ASP A 31 -24.748 -23.430 19.450 1 ∎ 00 39.99 0
ATOM 189 N ILE A 32 -25.309 -21.922 17.890 1 .00 35.25 NATOM 189 N ILE A 32 -25.309 -21.922 17.890 1 .00 35.25 N
ATOM 190 CA ILE A 32 - 25.089 - 22.861 16.802 1 .00 32.09 CATOM 190 CA ILE A 32-25.089-22.861 16.802 1 .00 32.09 C
ATOM 191 CB ILE A 32 -25.709 -22.352 15.494 1 ■ 00 29.93 C
Figure imgf000035_0001
ATOM 191 CB ILE A 32 -25.709 -22.352 15.494 1 ■ 00 29.93 C
Figure imgf000035_0001
Figure imgf000035_0002
Figure imgf000035_0002
o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o ζ ζ ο ζ ο ο ζ ο ο ζ ο ζ ο ο ο ο ζ ο ο ο ο ζ σ o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o ζ ζ ο ζ ο ο ζ ο ο ο ζ ο ο ο ζ ο ο ο
100 ATOM 228 C ARG A 36 -23.850 -25.544 11.031 1.00 26.92 C100 ATOM 228 C ARG A 36 -23.850 -25.544 11.031 1.00 26.92 C
ATOM 229 0 ARG A 36 -24.610 - 25.552 10.066 1. 00 26.78 0ATOM 229 0 ARG A 36 -24.610-25.552 10.066 1. 00 26.78 0
ATOM 230 N PHE A 37 - 23.169 - 24.467 11. 405 1. 00 26.46 NATOM 230 N PHE A 37-23.169-24.467 11. 405 1. 00 26.46 N
ATOM 231 CA PHE A 37 - 23.351 -23.202 10.719 1. 00 25.48 CATOM 231 CA PHE A 37-23.351 -23.202 10.719 1. 00 25.48 C
ATOM 232 CB PHE A 37 -22.694 - 22.075 11. 510 1. 00 24.74 CATOM 232 CB PHE A 37 -22.694-22.075 11. 510 1. 00 24.74 C
ATOM 233 CG PHE A 37 - 23.138 -20.711 11. 093 1. 00 23.71 CATOM 233 CG PHE A 37-23.138 -20.711 11. 093 1. 00 23.71 C
ATOM 234 CD1 PHE A 37 - 24.275 - 20.140 11. 643 1. 00 25.20 CATOM 234 CD1 PHE A 37-24.275-20.140 11. 643 1. 00 25.20 C
ATOM 235 CD2 PHE A 37 -22.413 -19.987 10.159 1. 00 26.79 CATOM 235 CD2 PHE A 37 -22.413 -19.987 10.159 1. 00 26.79 C
ATOM 236 CE1 PHE A 37 -24.684 -18.864 11. 269 1. 00 24.55 CATOM 236 CE1 PHE A 37 -24.684 -18.864 11. 269 1. 00 24.55 C
ATOM 237 CE2 PHE A 37 - 22.815 -18.707 9.779 1. 00 26.25 CATOM 237 CE2 PHE A 37-22.815 -18.707 9.779 1. 00 26.25 C
ATOM 238 CZ PHE A 37 - 23.955 -18.147 10.339 1. 00 26.49 CATOM 238 CZ PHE A 37-23.955 -18.147 10.339 1. 00 26.49 C
ATOM 239 C PHE A 37 -22.785 -23.256 9.303 1. 00 23.70 CATOM 239 C PHE A 37 -22.785 -23.256 9.303 1. 00 23.70 C
ATOM 240 0 PHE A 37 - 23.380 -22.715 8. 384 1. 00 24.59 . 0ATOM 240 0 PHE A 37-23.380 -22.715 8. 384 1. 00 24.59. 0
ATOM 241 N ARG A 38 -21.642 -23.911 9. 132 1. 00 23.38 NATOM 241 N ARG A 38 -21.642 -23.911 9. 132 1. 00 23.38 N
ATOM 242 CA ARG A 38 -21.091 - 24.162 7. 802 1. 00 22.89 CATOM 242 CA ARG A 38 -21.091-24.162 7. 802 1.00 22.89 C
ATOM 243 CB ARG A 38 -19.701 -24.788 7. 891 1. 00 23.40 cATOM 243 CB ARG A 38 -19.701 -24.788 7. 891 1. 00 23.40 c
ATOM 244 CG ARG A 38 -18.646 - 23.879 8. 449 1. 00 22.25 cATOM 244 CG ARG A 38 -18.646-23.879 8. 449 1. 00 22.25 c
ATOM 245 CD ARG A 38 -17.327 - 24.615 8. 566 1. 00 22.95 cATOM 245 CD ARG A 38 -17.327-24.615 8. 566 1.00 22.95 c
0 0  0 0
ATOM 246 NE ARG A 38 -16.297 - 23.758 9. 141 1. 00 23.57 N ATOM 246 NE ARG A 38 -16.297-23.758 9. 141 1. 00 23.57 N
ATOM 247 CZ ARG A 38 -15.242 -24.211 9. 801 1. 00 24.40 CATOM 247 CZ ARG A 38 -15.242 -24.211 9. 801 1. 00 24.40 C
ATOM 248 NH1 ARG A 38 -15.081 -25.516 9. 969 1. ,00 ATOM 248 NH1 ARG A 38 -15.081 -25.516 9.969 1., 00
ATOM 249 NH2 ARG A 38 -14.351 - 23.360 10. 291 1. 00 23.38 N ATOM 249 NH2 ARG A 38 -14.351-23.360 10. 291 1. 00 23.38 N
ATOM 250 C ARG A 38 -21.976 - 25.094 6. 996 1. ,00
Figure imgf000036_0001
CATOM 250 C ARG A 38 -21.976-25.094 6. 996 1., 00
Figure imgf000036_0001
C
ATOM 251 0 ARG A 38 -22.245 -24.841 5. 830 1. ,00 23.20 0ATOM 251 0 ARG A 38 -22.245 -24.841 5.830 1., 00 23.20 0
ATOM 252 N GLU A 39 -22.415 -26.184 7. 610 1. .00 23.34 NATOM 252 N GLU A 39 -22.415 -26.184 7. 610 1. .00 23.34 N
ATOM 253 CA GLU A 39 - 23.331 -27.091 6. 927 1. .00 25.57 CATOM 253 CA GLU A 39-23.331 -27.091 6. 927 1. .00 25.57 C
ATOM 254 GB GLU A 39 -24.029 -28.031 7. 914 1. .00 24.99 CATOM 254 GB GLU A 39 -24.029 -28.031 7.914 1. .00 24.99 C
ATOM 255 CG GLU A 39 -23.203 - 29.206 8. 406 1. .00 27.25 CATOM 255 CG GLU A 39 -23.203-29.206 8. 406 1. .00 27.25 C
ATOM 256 CD GLU A 39 -23.934 -30.010 9. 470 1. .00 26.56 CATOM 256 CD GLU A 39 -23.934 -30.010 9. 470 1. .00 26.56 C
ATOM 257 0E1 GLU A 39 -25.176 -29.995 9. 478 1. .00 23.65 0ATOM 257 0E1 GLU A 39 -25.176 -29.995 9. 478 1. .00 23.65 0
ATOM 258 0E2 GLU A 39 - 23.267 -30.659 10. 303 1, .00 31.79 0ATOM 258 0E2 GLU A 39-23.267 -30.659 10. 303 1, .00 31.79 0
ATOM 259 C GLU A 39 -24.391 -26.254 6. 239 1, .00 24.28 CATOM 259 C GLU A 39 -24.391 -26.254 6. 239 1, .00 24.28 C
ATOM 260 0 GLU A 39 -24.573 -26.333 5. 024 1 .00 25.79 0ATOM 260 0 GLU A 39 -24.573 -26.333 5. 024 1 .00 25.79 0
ATOM 261 N LEU A 40 - 25.077 -25.442 7. 036 1, .00 23.13 NATOM 261 N LEU A 40-25.077 -25.442 7. 036 1, .00 23.13 N
ATOM 262 CA LEU A 40 -26.284 -24.764 6. 592 1, .00 22.72 CATOM 262 CA LEU A 40 -26.284 -24.764 6. 592 1, .00 22.72 C
ATOM 263 CB LEU A 40 一 27.043 -24.197 7. ,799 1 .00 20.42 C ATOM 264 CG LEU A 40 -27.719 -25.268 8.665 1.00 19.06 CATOM 263 CB LEU A 40 1 27.043 -24.197 7., 799 1.00 20.42 C ATOM 264 CG LEU A 40 -27.719 -25.268 8.665 1.00 19.06 C
ATOM 265 CD1 LEU A 40 -28.144 -24.693 10.015 1. 00 16.04 CATOM 265 CD1 LEU A 40 -28.144 -24.693 10.015 1.00 16.04 C
ATOM 266 CD2 LEU A 40 -28.920 -25.838 7.907 1. 00 15.30 CATOM 266 CD2 LEU A 40 -28.920 -25.838 7.907 1. 00 15.30 C
ATOM 267 C LEU A 40 -25.955 -23.660 5.607 1. 00 23.05 CATOM 267 C LEU A 40 -25.955 -23.660 5.607 1. 00 23.05 C
ATOM 268 0 LEU A 40 -26.708 -23.424 4.661 1. 00 23.46 0ATOM 268 0 LEU A 40 -26.708 -23.424 4.661 1. 00 23.46 0
ATOM 269 N ALA A 41 -24.821 -22.998 5.814 1. 00 22.02 NATOM 269 N ALA A 41 -24.821 -22.998 5.814 1. 00 22.02 N
ATOM 270 GA ALA A 41 -24.409 -21.939 4.906 1. 00 23.08 CATOM 270 GA ALA A 41 -24.409 -21.939 4.906 1. 00 23.08 C
ATOM 271 CB ALA A 41 - 23.093 -21 · 341 5.357 1. 00 23.04 CATOM 271 CB ALA A 41-23.093 -21 · 341 5.357 1. 00 23.04 C
ATOM 272 C ALA A 41 -24.282 -22.476 3.481 1. 00 22.66 CATOM 272 C ALA A 41 -24.282 -22.476 3.481 1. 00 22.66 C
ATOM 273 0 ALA A 41 -24.713 -21.828 2.522 1. 00 19.82 0ATOM 273 0 ALA A 41 -24.713 -21.828 2.522 1. 00 19.82 0
ATOM 274 N SER A 42 -23.708 -23.664 3.336 1. 00 21.76 NATOM 274 N SER A 42 -23.708 -23.664 3.336 1. 00 21.76 N
ATOM 275 . CA SER A 42 -23.515 -24.205 2.003 1. 00 23.86 CATOM 275. CA SER A 42 -23.515 -24.205 2.003 1. 00 23.86 C
ATOM 276 CB SER A 42 -22.409 -25.276 2.000 1. 00 25.89 CATOM 276 CB SER A 42 -22.409 -25.276 2.000 1. 00 25.89 C
ATOM 277 OG SER A 42 -22.600 -26.230 3.026 1. 00 33.13 0ATOM 277 OG SER A 42 -22.600 -26.230 3.026 1. 00 33.13 0
ATOM 278 C SER A 42 -24.816 - 24.767 1.440 1. 00 23.00 GATOM 278 C SER A 42 -24.816-24.767 1.440 1. 00 23.00 G
ATOM 279 0 SER A 42 - 25.104 -24.582 0.262 1. ,00 23.51 0ATOM 279 0 SER A 42-25.104 -24.582 0.262 1., 00 23.51 0
ATOM 280 N 6LU A 43 -25.611 -25.431 2.277 1. .00 23.53 NATOM 280 N 6LU A 43 -25.611 -25.431 2.277 1. .00 23.53 N
ATOM 281 CA GLU A 43 -26.881 -25.988 1.819 1. .00 23.97 CATOM 281 CA GLU A 43 -26.881 -25.988 1.819 1. .00 23.97 C
ATOM 282 CB 6LU A 43 - 27.588 - 26.745 2.949 1. ,00 23.21 CATOM 282 CB 6LU A 43-27.588-26.745 2.949 1., 00 23.21 C
ATOM 283 CG GLU A 43 -26.866 -27.987 3.413 1. ,00 20.47 CATOM 283 CG GLU A 43 -26.866 -27.987 3.413 1., 00 20.47 C
ATOM 284 CD GLU A 43 -27.541 -28.663 4.590 1. .00 20.38 CATOM 284 CD GLU A 43 -27.541 -28.663 4.590 1. .00 20.38 C
ATOM 285 0E1 GLU A 43 -28.736 -28.399 4.853 1. .00 18.82 0ATOM 285 0E1 GLU A 43 -28.736 -28.399 4.853 1. .00 18.82 0
ATOM 286 0E2 GLU A 43 -26.866 - 29.466 5.259 1, .00 23.67 0ATOM 286 0E2 GLU A 43 -26.866-29.466 5.259 1, .00 23.67 0
ATOM 287 C GLU A 43 -27.817 -24.905 1.284 1. .00 25.45 CATOM 287 C GLU A 43 -27.817 -24.905 1.284 1. .00 25.45 C
ATOM 288 0 GLU A 43 -28.472 -25.091 0.249 1, .00 27.71 0ATOM 288 0 GLU A 43 -28.472 -25.091 0.249 1, .00 27.71 0
ATOM 289 N VAL A 44 -27.894 -23.778 1.982 1, .00 24.55 NATOM 289 N VAL A 44 -27.894 -23.778 1.982 1, .00 24.55 N
ATOM 290 CA VAL A 44 -28.768 - 22.703 1.520 1, .00 25.58 CATOM 290 CA VAL A 44 -28.768-22.703 1.520 1, .00 25.58 C
ATOM 291 CB VAL A 44 -29.012 -21.645 2.632 1, .00 26.18 CATOM 291 CB VAL A 44 -29.012 -21.645 2.632 1, .00 26.18 C
ATOM 292 CG1 VAL A 44 -29.834 -22.250 3.751 1 .00 25.28 CATOM 292 CG1 VAL A 44 -29.834 -22.250 3.751 1 .00 25.28 C
ATOM 293 CG2 VAL A 44 -27.679 3.196 1 .00 30.84 CATOM 293 CG2 VAL A 44 -27.679 3.196 1 .00 30.84 C
ATOM 294 C VAL A 44 -28.177 -22.032 0.280 1 .00 22.71 CATOM 294 C VAL A 44 -28.177 -22.032 0.280 1 .00 22.71 C
ATOM 295 0 VAL A 44 -28.900 -21.689 -0.654 1 .00 23.44 0ATOM 295 0 VAL A 44 -28.900 -21.689 -0.654 1 .00 23.44 0
ATOM 296 N GLY A 45 - 26.861 -21.868 0.256 1 .00 21.76 NATOM 296 N GLY A 45-26.861 -21.868 0.256 1 .00 21.76 N
ATOM 297 CA GLY A 45 -26.224 -21.345 - 0.940 1 .00 22.03 CATOM 297 CA GLY A 45 -26.224 -21.345-0.940 1 .00 22.03 C
ATOM 298 C GLY A 45 -26.548 -22.199 -2.160 1 ■ 00 22.37 CATOM 298 C GLY A 45 -26.548 -22.199 -2.160 1 ■ 00 22.37 C
ATOM 299 0 GLY A 45 -26.891 -21.686 -3.236 1 .00 20.21 0 ATOM 300 N SER A 46 -26.443 -23.509 一 1.988 1.00 19.18 NATOM 299 0 GLY A 45 -26.891 -21.686 -3.236 1 .00 20.21 0 ATOM 300 N SER A 46 -26.443 -23.509 One 1.988 1.00 19.18 N
ATOM 301 GA SER A 46 - 26.742 -24.437 -3.061 1. 00 20.53 CATOM 301 GA SER A 46-26.742 -24.437 -3.061 1. 00 20.53 C
ATOM 302 CB SER A 46 - 26.582 -25.871 -2.563 1. 00 19.86 CATOM 302 CB SER A 46-26.582 -25.871 -2.563 1. 00 19.86 C
ATOM 303 OG SER A 46 -26.934 -26.787 -3.578 1. 00 23.81 0ATOM 303 OG SER A 46 -26.934 -26.787 -3.578 1.00 23.81 0
ATOM 304 C SER A 46 -28.172 - 24.226 - 3.566 1. 00 22.52 CATOM 304 C SER A 46 -28.172-24.226-3.566 1. 00 22.52 C
ATOM 305 0 SER A 46 -28.414 -24.182 -4. 776 1. 00 19.95 0ATOM 305 0 SER A 46 -28.414 -24.182 -4. 776 1. 00 19.95 0
ATOM 306 N LEU A 47 -29.113 -24.091 -2. 631 1. 00 21. 37 NATOM 306 N LEU A 47 -29.113 -24.091 -2. 631 1. 00 21. 37 N
ATOM 307 CA LEU A 47 -30.516 -23.900 - 2. 980 1. 00 22.83 CATOM 307 CA LEU A 47 -30.516 -23.900-2. 980 1.00 22.83 C
ATOM 308 CB LEU A 47 -31， 385 -23.954 - 1. 717 1. 00 22.34 CATOM 308 CB LEU A 47 -31, 385 -23.954-1. 717 1. 00 22.34 C
ATOM 309 CG LEU A 47 -31. 990 -25.307 - 1. 303 1. 00 21. 32 GATOM 309 CG LEU A 47 -31. 990 -25.307-1. 303 1. 00 21. 32 G
ATOM 310 CD1 LEU A 47 - 31. 136 - 26.464 - 1. 773 1. 00 23. 21 CATOM 310 CD1 LEU A 47-31. 136-26.464-1. 773 1. 00 23. 21 C
ATOM 311 CD2 LEU A 47 一 32, 146 -25.342 0. 196 1. 00 21. 45 CATOM 311 CD2 LEU A 47 1 32, 146 -25.342 0. 196 1. 00 21. 45 C
ATOM 312 C LEU A 47 -30. 757 - 22.591 - 3. 725 1. 00 22. 73 CATOM 312 C LEU A 47 -30. 757-22.591-3. 725 1. 00 22. 73 C
ATOM 313 0 LEU A 47 -31. 555 -22.542 -4. 661 1. 00 25. 23 0ATOM 313 0 LEU A 47 -31. 555 -22.542 -4. 661 1. 00 25. 23 0
ATOM 314 N LEU A 48 - 30. 069 -21.527 - 3. 324 1. 00 22. 30 NATOM 314 N LEU A 48-30. 069 -21.527-3. 324 1. 00 22. 30 N
ATOM 315 CA LEU A 48 -30. 251 -20.242 - 3. 987 1. 00 20. 51 CATOM 315 CA LEU A 48 -30. 251 -20.242-3. 987 1. 00 20. 51 C
ATOM 316 CB LEU A 48 - 29. 571 -19.120 - 3. 197 1. 00 18. 68 CATOM 316 CB LEU A 48-29. 571 -19.120-3. 197 1. 00 18. 68 C
ATOM 317 CG LEU A 48 -30. 024 -18.952 - 1. 745 1. , 00 20. 84 CATOM 317 CG LEU A 48 -30. 024 -18.952-1. 745 1., 00 20. 84 C
ATOM 318 CD1 LEU A 48 -29. 094 -17.995 -1. 044 1. ,00 16. 87 CATOM 318 CD1 LEU A 48 -29. 094 -17.995 -1. 044 1., 00 16. 87 C
ATOM 319 CD2 LEU A 48 -31. 472 -18.447 - 1. 686 1. 00 18. 19 CATOM 319 CD2 LEU A 48 -31. 472 -18.447-1. 686 1. 00 18. 19 C
ATOM 320 C LEU A 48 -29. 679 - 20.298 - 5. 398 1. , 00 20. 57 CATOM 320 C LEU A 48 -29. 679-20.298-5. 398 1., 00 20. 57 C
ATOM 321 0 LEU A 48 -30. 118 -19.562 - 6. 276 1. ,00 21. 23 0ATOM 321 0 LEU A 48 -30. 118 -19.562-6. 276 1., 00 21. 23 0
ATOM 322 N THR A 49 -28. 699 - 21.171 -5. 613 1. ,00 22. 09 NATOM 322 N THR A 49 -28. 699-21.171 -5. 613 1., 00 22. 09 N
ATOM 323 CA THR A 49 —28. 066 -21.299 - 6. 923 1. , 00 23. 62 CATOM 323 CA THR A 49 —28. 066 -21.299-6. 923 1., 00 23. 62 C
ATOM 324 CB THR A 49 -26. 832 - 22.235 -6. 871 1. ,00 24. 74 CATOM 324 CB THR A 49 -26. 832-22.235 -6. 871 1., 00 24. 74 C
ATOM 325 061 THR A 49 -25. 839 - 21.686 -5. 994 1. , 00 26. 89 0ATOM 325 061 THR A 49 -25. 839-21.686 -5. 994 1., 00 26. 89 0
ATOM 326 CG2 THR A 49 - 26. 230 -22.401 -8. 260 1. ■ 00 26. 21 CATOM 326 CG2 THR A 49-26. 230 -22.401 -8. 260 1. ■ 00 26. 21 C
ATOM 327 C THR A 49 -29. 068 -21.870 - 7. 919 1. ,00 24. 95 CATOM 327 C THR A 49 -29. 068 -21.870-7. 919 1., 00 24. 95 C
ATOM 328 0 THR A 49 -29. 157 -21.425 - 9. 064 1. ■ 00 25. 44 0ATOM 328 0 THR A 49 -29. 157 -21.425-9. 064 1. ■ 00 25. 44 0
ATOM 329 N TYR A 50 - 29. 825 -22.862 - 7. 472 1. .00 26. 67 NATOM 329 N TYR A 50-29. 825 -22.862-7. 472 1. .00 26. 67 N
ATOM 330 CA TYR A 50 -30. 849 -23.470 -8. 309 1, .00 28. 28 CATOM 330 CA TYR A 50 -30. 849 -23.470 -8. 309 1, .00 28. 28 C
ATOM 331 CB TYR A 50 -31. 617 -24.521 -7. 509 1, .00 28. 22 CATOM 331 CB TYR A 50 -31. 617 -24.521 -7. 509 1, .00 28. 22 C
ATOM 332 CG TYR A 50 -32. 559 -25.348 - 8. 337 1, .00 30. 14 CATOM 332 CG TYR A 50 -32. 559 -25.348-8. 337 1, .00 30. 14 C
ATOM 333 CD1 TYR A 50 -32. 077 -26.328 - 9. 191 1, .00 31. 09 CATOM 333 CD1 TYR A 50 -32. 077 -26.328-9. 191 1, .00 31. 09 C
ATOM 334 CE1 TYR A 50 -32. 940 - 27.125 -9. 926 1 .00 31. 90 CATOM 334 CE1 TYR A 50 -32. 940-27.125 -9. 926 1 .00 31. 90 C
ATOM 335 CD2 TYR A 50 —33. 934 -25.178 -8. 241 1, .00 29. 48 C ATOM 336 CE2 TYR A 50 -34.804 - 25.965 -8.972 1.00 30.28 CATOM 335 CD2 TYR A 50 —33. 934 -25.178 -8. 241 1, .00 29. 48 C ATOM 336 CE2 TYR A 50 -34.804-25.965 -8.972 1.00 30.28 C
ATOM 337 CZ TYR A 50 -34.299 -26.936 -9.813 1. 00 31.91 CATOM 337 CZ TYR A 50 -34.299 -26.936 -9.813 1.00 31.91 C
ATOM 338 OH TYR A 50 - 35.150一 27.716 -10.558 1. 00 32.79 0ATOM 338 OH TYR A 50-35.150 1 27.716 -10.558 1. 00 32.79 0
ATOM 339 C TYR A 50 -31. 810 -22.389 -8.776 1. 00 28.28 CATOM 339 C TYR A 50 -31. 810 -22.389 -8.776 1. 00 28.28 C
ATOM 340 0 TYR A 50 -32.147 - 22.303 -9.958 1. 00 28.72 0ATOM 340 0 TYR A 50 -32.147-22.303 -9.958 1.00 28.72 0
ATOM 341 N GLU A 51 - 32.247 -21. 564 - 7.833 1. 00 27.56 NATOM 341 N GLU A 51-32.247 -21. 564-7.833 1. 00 27.56 N
ATOM 342 CA GLU A 51 -33.171 -20.492 -8.135 1. 00 27.79 CATOM 342 CA GLU A 51 -33.171 -20.492 -8.135 1.00 27.79 C
ATOM 343 CB GLU A 51 -33.591 - 19. 795 -6.835 1. 00 30.17 CATOM 343 CB GLU A 51 -33.591-19. 795 -6.835 1. 00 30.17 C
ATOM 344 CG GLU A 51 -34.313 - 20. 714 -5.842 1. 00 30.70 CATOM 344 CG GLU A 51 -34.313-20. 714 -5.842 1. 00 30.70 C
ATOM 345 CD GLU A 51 -35.734 - 21. 054 -6.275 1. 00 32.27 CATOM 345 CD GLU A 51 -35.734-21. 054 -6.275 1.00 32.27 C
ATOM 346 0E1 GLU A 51 .. -36. 201 -20. 474 -7.277 1. 00 33.76 0ATOM 346 0E1 GLU A 51 .. -36. 201 -20. 474 -7.277 1. 00 33.76 0
ATOM: 347 0E2 GLU A 51 -36. 385 -21. 899 -5.617 1. 00 33.01 0ATOM: 347 0E2 GLU A 51 -36. 385 -21. 899 -5.617 1.00 33.01 0
ATOM 348 C GLU A 51 -32. 522 -19. 498 -9.093 1. 00 25.92 . CATOM 348 C GLU A 51 -32. 522 -19. 498 -9.093 1. 00 25.92.
ATOM 349 0 GLU A 51 -33. 118 -19. 112 -10.089 1. 00 27.75 0ATOM 349 0 GLU A 51 -33. 118 -19. 112 -10.089 1. 00 27.75 0
ATOM 350 N ALA A 52 - 31. 289 -19. 109 -8.804 1. 00 24.47 NATOM 350 N ALA A 52-31. 289 -19. 109 -8.804 1. 00 24.47 N
ATOM 351 CA ALA A 52 -30. 614 -18. 070 -9.575 1. 00 25.52 CATOM 351 CA ALA A 52 -30. 614 -18. 070 -9.575 1. 00 25.52 C
ATOM 352 CB ALA A 52 -29. 422一 17. 534 -8.790 1. 00 23.81 CATOM 352 CB ALA A 52 -29.422 one 17.534 -8.790 1.00 23.81 C
ATOM 353 C ALA A 52 - 30. 147 - 18. 525 -10.957 1. 00 24.81 CATOM 353 C ALA A 52-30. 147-18. 525 -10.957 1. 00 24.81 C
ATOM 354 0 ALA A 52 -29. 663 -17. 711 -11.738 1. 00 .26.48 0ATOM 354 0 ALA A 52 -29. 663 -17. 711 -11.738 1. 00 .26.48 0
ATOM 355 N THR A 53 -30. 277 -19. 811 -11 - 257 1. 00 22.73 NATOM 355 N THR A 53 -30. 277 -19. 811 -11-257 1. 00 22.73 N
ATOM 356 CA THR A 53 -29. 736 -20. 346 -12.503 1. ,00 26.10 CATOM 356 CA THR A 53 -29. 736 -20. 346 -12.503 1., 00 26.10 C
ATOM 357 CB THR A 53 -28. 659 -21. 431 -12.242 1. 00 26.52 CATOM 357 CB THR A 53 -28. 659 -21. 431 -12.242 1. 00 26.52 C
ATOM 358 061 THR A 53 -29. 229 - 22. 490 -11.467 1. ,00 26.48 0ATOM 358 061 THR A 53 -29. 229-22. 490 -11.467 1., 00 26.48 0
ATOM 359 CG2 THR A 53 - 27. 476 -20. 855 - 11.486 1. ,00 27.55 CATOM 359 CG2 THR A 53-27. 476 -20. 855-11.486 1., 00 27.55 C
ATOM 360 C THR A 53 -30. 814 -20. 955 -13.400 1. ,00 27.02 CATOM 360 C THR A 53 -30. 814 -20. 955 -13.400 1., 00 27.02 C
ATOM 361 0 THR A 53 -30. 508 - 21. 655 -14.360 1. .00 29.36 0ATOM 361 0 THR A 53 -30. 508-21. 655 -14.360 1. .00 29.36 0
ATOM 362 N ALA A 54 -32. 074 - 20. 690 -13.084 1. ,00 27.65 NATOM 362 N ALA A 54 -32. 074-20. 690 -13.084 1., 00 27.65 N
ATOM 363 CA ALA A 54 - 33. 180 -21. 261 -13.842 1. .00 30.26 CATOM 363 CA ALA A 54-33. 180 -21. 261 -13.842 1. .00 30.26 C
ATOM 364 CB ALA A 54 -34. 482 -21. 037 -13.098 1. .00 30.00 CATOM 364 CB ALA A 54 -34. 482 -21. 037 -13.098 1. .00 30.00 C
ATO 365 C ALA A 54 - 33. 276 -20. 683 -15.255 1. ,00 32.53 CATO 365 C ALA A 54-33. 276 -20. 683 -15.255 1., 00 32.53 C
ATOM 366 0 ALA A 54 - 33. 985 -21. 222 -16.101 1. .00 33.86 0ATOM 366 0 ALA A 54-33. 985 -21. 222 -16.101 1. .00 33.86 0
ATOM 367 N ASP A 55 -32. 560 -19. 595 -15.515 1. .00 33.91 NATOM 367 N ASP A 55 -32. 560 -19. 595 -15.515 1. .00 33.91 N
ATOM 368 CA ASP A 55 -32. 605 -18. 955 -16.827 1, .00 35.97 GATOM 368 CA ASP A 55 -32. 605 -18. 955 -16.827 1, .00 35.97 G
ATOM 369 CB ASP A 55 -32. 853 -17. 452 -16.672 1, .00 36.82 CATOM 369 CB ASP A 55 -32. 853 -17. 452 -16.672 1, .00 36.82 C
ATOM 370 CG ASP A 55 -31. 653 -16. 727 -16.087 1, .00 38.59 CATOM 370 CG ASP A 55 -31. 653 -16. 727 -16.087 1, .00 38.59 C
ATOM 371 0D1 ASP A 55 一 30. 990 -17. 309一 15.202 1, .00 38.36 0 ATOM 372 0D2 ASP A 55 -31.369 -15.586 -16.511 1.00 41.17 0ATOM 371 0D1 ASP A 55 One 30. 990 -17. 309 One 15.202 1, .00 38.36 0 ATOM 372 0D2 ASP A 55 -31.369 -15.586 -16.511 1.00 41.17 0
ATOM 373 C ASP A 55 -31 · 337一 19.161 - 17.664 1. 00 35.91 CATOM 373 C ASP A 55 -31 337 1 19.161-17.664 1.00 35.91 C
ATOM 374 0 ASP A 55 - 31.119 -18.447 - 18.638 1. 00 35.13 0ATOM 374 0 ASP A 55-31.119 -18.447-18.638 1. 00 35.13 0
ATOM 375 N LEU A 56 -30.494 -20.118 -17.290 1. 00 36.79 NATOM 375 N LEU A 56 -30.494 -20.118 -17.290 1. 00 36.79 N
ATOM 376 CA LEU A 56 -29.299 - 20.393 -18.083 1. 00 38.26 GATOM 376 CA LEU A 56 -29.299-20.393 -18.083 1. 00 38.26 G
ATOM 377 CB LEU A 56 -28.401 -21.409 -17.381 1. 00 37.55 CATOM 377 CB LEU A 56 -28.401 -21.409 -17.381 1. 00 37.55 C
ATOM 378 CG LEU A 56 -27.634 -20.928 -16.152 1. 00 38.03 CATOM 378 CG LEU A 56 -27.634 -20.928 -16.152 1.00 38.03 C
ATOM 379 CD1 LEU A 56 -26.890 -22.102 - 15.537 1. 00 34.43 CATOM 379 CD1 LEU A 56 -26.890 -22.102-15.537 1.00 34.43 C
ATOM 380 CD2 LEU A 56 -26.667 -19.810 -16.546 1. 00 36.79 CATOM 380 CD2 LEU A 56 -26.667 -19.810 -16.546 1.00 36.79 C
ATOM 381 C LEU A 56 -29.663 - 20.925 -19.467 1. 00 39.57 CATOM 381 C LEU A 56 -29.663-20.925 -19.467 1. 00 39.57 C
ATOM 382 0 LEU A 56 - 30.655 -21.643 -19.635 1. 00 37.95 0ATOM 382 0 LEU A 56-30.655 -21.643 -19.635 1. 00 37.95 0
ATOM 383 .N 6LU A 57 -28.851 - 20.571 -20.457 1. 00 41.63 NATOM 383 .N 6LU A 57 -28.851-20.571 -20.457 1.00 41.63 N
ATOM 384 CA GLU A 57 -29.033 -21.085 -21.807 1. 00 43.90 CATOM 384 CA GLU A 57 -29.033 -21.085 -21.807 1.00 43.90 C
ATOM 385 CB GLU A 57 -28.440 -20.112 -22.831 1. 00 46.62 CATOM 385 CB GLU A 57 -28.440 -20.112 -22.831 1. 00 46.62 C
ATOM 386 C6 GLU A 57 -26.978 -19.753 - 22.596 1. , 00 52.24 CATOM 386 C6 GLU A 57 -26.978 -19.753-22.596 1., 00 52.24 C
ATOM 387 CD GLU A 57 - 26.496 -18.613 - 23.493 1. 00 55.82 CATOM 387 CD GLU A 57-26.496 -18.613-23.493 1. 00 55.82 C
ATOM 388 0E1 GLU A 57 -26.091 - 17.555 -22.954 1. , 00 56.20 0ATOM 388 0E1 GLU A 57 -26.091-17.555 -22.954 1., 00 56.20 0
ATOM 389 0E2 GLU A 57 -26.518 - 18.779 -24.735 1. , 00 56.61 0ATOM 389 0E2 GLU A 57 -26.518-18.779 -24.735 1., 00 56.61 0
ATOM 390 C GLU A 57 -28.368 - 22.446 -21.937 1. .00 43.49 CATOM 390 C GLU A 57 -28.368-22.446 -21.937 1. .00 43.49 C
ATOM 391 0 GLU A 57 -27.260 -22.647 - 21■ 448 1. ,00 42.13 0ATOM 391 0 GLU A 57 -27.260 -22.647-21 ■ 448 1., 00 42.13 0
ATOM 392 N THR A 58 -29.056 -23.385 - 22.580 1. , 00 44.90 ATOM 392 N THR A 58 -29.056 -23.385-22.580 1., 00 44.90
ATOM 393 CA TH A 58 -28.455 -24.671 -22.912 1. .00 45.52 C ATOM 393 CA TH A 58 -28.455 -24.671 -22.912 1. .00 45.52 C
ATOM 394 CB THR A 58 - 29.373 - 25.854 -22.532 1. .00 45.15 CATOM 394 CB THR A 58-29.373-25.854 -22.532 1. .00 45.15 C
ATOM 395 0G1 THR A 58 -30.514 -25.882 -23.400 1, .00 42.27 0ATOM 395 0G1 THR A 58 -30.514 -25.882 -23.400 1, .00 42.27 0
ATOM 396 CG2 THR A 58 -29.834 -25.722 -21.086 1, .00 43.90 CATOM 396 CG2 THR A 58 -29.834 -25.722 -21.086 1, .00 43.90 C
ATOM 397 C THR A 58 - 28.198 -24.723 -24.410 1, .00 46.99 CATOM 397 C THR A 58-28.198 -24.723 -24.410 1, .00 46.99 C
ATOM 398 0 THR A 58 -28.718 -23.899 - 25.160 1, ■ 00 47.00 0ATOM 398 0 THR A 58 -28.718 -23.899-25.160 1, ■ 00 47.00 0
ATOM 399 N GLU A 59 -27.390 - 25.685 - 24.838 1 .00 48.15 NATOM 399 N GLU A 59 -27.390-25.685-24.838 1 .00 48.15 N
ATOM 400 CA GLU A 59 -27.156 -25.917 -26.258 1 .00 50.19 CATOM 400 CA GLU A 59 -27.156 -25.917 -26.258 1 .00 50.19 C
ATOM 401 CB GLU A 59 -25.696 -25.639 -26.619 1 ■ 00 52.53 CATOM 401 CB GLU A 59 -25.696 -25.639 -26.619 1 ■ 00 52.53 C
ATOM 402 CG GLU A 59 - 25.212 -24.251 -26.260 1 .00 58.34 CATOM 402 CG GLU A 59-25.212 -24.251 -26.260 1 .00 58.34 C
ATOM 403 CD GLU A 59 -23.780 - 24.251 - 25.749 1 .00 62.08 CATOM 403 CD GLU A 59 -23.780-24.251-25.749 1 .00 62.08 C
ATOM 404 0E1 GLU A 59 -23.534 -23.654 -24.674 1 ■ 00 63.10 0ATOM 404 0E1 GLU A 59 -23.534 -23.654 -24.674 1 ■ 00 63.10 0
ATOM 405 0E2 GLU A 59 -22.904 -24.849 -26.419 1 .00 62.93 0ATOM 405 0E2 GLU A 59 -22.904 -24.849 -26.419 1 .00 62.93 0
ATOM 406 C GLU A 59 -27.474 -27.372 - 26.559 1 .00 49.93 CATOM 406 C GLU A 59 -27.474 -27.372-26.559 1 .00 49.93 C
ATOM 407 0 GLU A 59 -27.216 -28.248 -25.736 1 • 00 48.31 0 ATOM 408 N LYS A 60 - 28.032 -27.625 -27.738 1.00 51.11 NATOM 407 0 GLU A 59 -27.216 -28.248 -25.736 1 • 00 48.31 0 ATOM 408 N LYS A 60-28.032 -27.625 -27.738 1.00 51.11 N
ATOM 409 CA LYS A 60 - 28.282 -28.989 -28. 186 1. 00 51. 49 CATOM 409 CA LYS A 60-28.282 -28.989 -28. 186 1. 00 51. 49 C
ATOM 410 CB LYS A 60 -29.291 -28.996 -29. 329 1. 00 52.05 CATOM 410 CB LYS A 60 -29.291 -28.996 -29. 329 1. 00 52.05 C
ATOM 411 CG LYS A 60 - 30.623 -29.611 -28. 961 1. 00 54.01 CATOM 411 CG LYS A 60-30.623 -29.611 -28. 961 1. 00 54.01 C
ATOM 412 CD LYS A 60 - 31. 306 -28.836 -27. 850 1. 00 54.76 CATOM 412 CD LYS A 60-31. 306 -28.836 -27. 850 1. 00 54.76 C
ATOM 413 CE LYS A 60 -32.593 -29.521 -27. 410 1. 00 55.30 CATOM 413 CE LYS A 60 -32.593 -29.521 -27. 410 1. 00 55.30 C
ATOM 414 NZ LYS A 60 -32.329 -30.813 - 26. 708 1. 00 57.01 NATOM 414 NZ LYS A 60 -32.329 -30.813-26. 708 1. 00 57.01 N
ATOM 415 C LYS A 60 -26. 990 -29.637 -28. 654 1. 00 51. 83 CATOM 415 C LYS A 60 -26. 990 -29.637 -28. 654 1. 00 51. 83 C
ATOM 416 0 LYS A 60 -26. 322 -29. 132 - 29. 555 1. 00 53.41 0ATOM 416 0 LYS A 60 -26. 322 -29. 132-29. 555 1. 00 53.41 0
ATOM 417 N VAL A 61 - 26. 645 -30.757 -28. 031 1. 00 51. 56 NATOM 417 N VAL A 61-26. 645 -30.757 -28. 031 1. 00 51. 56 N
ATOM 418 CA VAL A 61 -25. 418 -31. 475 -28. 343 1. 00 50.58 CATOM 418 CA VAL A 61 -25. 418 -31. 475 -28. 343 1. 00 50.58 C
ATOM 419 CB VAL A 61 -24. 433 -31. 404 - 27. 164 1. 00 50.08 CATOM 419 CB VAL A 61 -24. 433 -31. 404-27. 164 1. 00 50.08 C
ATOM 420 CG1 VAL A 61 -23. 155一 32, 137 -27. 504 1. 00 51. 05 CATOM 420 CG1 VAL A 61 -23. 155 1 32, 137 -27. 504 1. 00 51. 05 C
ATOM 421 CG2 VAL A 61 -24. 148 -29. 959 - 26. 820 1. 00 51. 07 CATOM 421 CG2 VAL A 61 -24. 148 -29. 959-26. 820 1. 00 51. 07 C
ATOM 422 C VAL A 61 -25. 753 -32, 938 -28. 617 1. ,00 50. 65 CATOM 422 C VAL A 61 -25. 753 -32, 938 -28. 617 1., 00 50. 65 C
ATOM 423 0 VAL A 61 -26. 463 -33. 572 -27. 833 1. 00 49. 21 0ATOM 423 0 VAL A 61 -26. 463 -33. 572 -27. 833 1. 00 49. 21 0
ATOM 424 N THR A 62 -25. 250 -33. 468 - 29. 729 1. ,00 50. 34 NATOM 424 N THR A 62 -25. 250 -33. 468-29. 729 1., 00 50. 34 N
ATOM 425 GA THR A 62 - 25. 454 - 34. 873 - 30. 067 1. ,00 50. 67 CATOM 425 GA THR A 62-25. 454-34. 873-30. 067 1., 00 50. 67 C
ATOM 426 CB THR A 62 - 25. 646 -35. 076 -31. 582 1. ,00 51. 43 CATOM 426 CB THR A 62-25. 646 -35. 076 -31. 582 1., 00 51. 43 C
ATOM 427 0G1 THR A 62 - 26. 918 -34. 550 -31. 980 1. .00 52. 29 0ATOM 427 0G1 THR A 62-26. 918 -34. 550 -31. 980 1. .00 52. 29 0
ATOM 428 CG2 THR A 62 - 25. 574 - 36. 555 -31. 934 1. ,00 50. 66 CATOM 428 CG2 THR A 62-25. 574-36. 555 -31. 934 1., 00 50. 66 C
ATOM 429 C THR A 62 - 24. 275 -35. 724 -29. 624 1. .00 50, 76 CATOM 429 C THR A 62-24. 275 -35. 724 -29. 624 1. .00 50, 76 C
ATOM 430 0 THR A 62 -23. 124一 35. 418 -29.937 1. .00 51. 75 0ATOM 430 0 THR A 62 -23. 124 1 35. 418 -29.937 1. .00 51. 75 0
ATOM 431 N ILE A 63 -24. 572 -36. 794 -28. 893 1, .00 49. 38 NATOM 431 N ILE A 63 -24. 572 -36. 794 -28. 893 1, .00 49. 38 N
ATOM 432 CA ILE A 63 -23. 539一 37. 699 -28. 412 1. .00 49. 12 CATOM 432 CA ILE A 63 -23. 539 37. 699 -28. 412 1. .00 49. 12 C
ATOM 433 CB ILE A 63 -23. 206 -37. 421 -26. 935 1. .00 47. 25 CATOM 433 CB ILE A 63 -23. 206 -37. 421 -26. 935 1. .00 47. 25 C
ATOM 434 CG2 ILE A 63 -22. 776 - 35. 983 -26. 774 1, .00 48. 14 CATOM 434 CG2 ILE A 63 -22. 776-35. 983 -26. 774 1, .00 48. 14 C
ATOM 435 C61 ILE A 63 - 24. 424 - 37. 678 -26. 054 1, .00 44. 82 CATOM 435 C61 ILE A 63-24. 424-37. 678 -26. 054 1, .00 44. 82 C
ATOM 436 CD1 ILE A 63 - 24. 089 -37. 686 - 24. 590 1, .00 43. 06 CATOM 436 CD1 ILE A 63-24. 089 -37. 686-24. 590 1, .00 43. 06 C
ATO 437 C ILE A 63 -23. 979 - 39. 154 - 28. 563 1, .00 49. 76 CATO 437 C ILE A 63 -23. 979-39. 154-28. 563 1, .00 49. 76 C
ATOM 438 0 ILE A 63 -25. 042 -39. 434 - 29. 117 1, .00 48. 64 0ATOM 438 0 ILE A 63 -25. 042 -39. 434-29. 117 1, .00 48. 64 0
ATOM 439 N GLU A 64 -23. 158 -40. 079 -28. 076 1, .00 50. 99 NATOM 439 N GLU A 64 -23. 158 -40. 079 -28. 076 1, .00 50. 99 N
ATOM 440 CA 6LU A 64 - 23. 459 -41. 498 -28. 227 1, .00 52. 15 CATOM 440 CA 6LU A 64-23. 459 -41. 498 -28. 227 1, .00 52. 15 C
ATOM 441 CB GLU A 64 - 22. 192 -42. 271 -28. 603 1 .00 52. 68 CATOM 441 CB GLU A 64-22. 192 -42. 271 -28. 603 1 .00 52. 68 C
ATOM 442 CG GLU A 64 -22. 462 -43. 670 -29. 115 1, .00 55. 62 CATOM 442 CG GLU A 64 -22. 462 -43. 670 -29. 115 1, .00 55. 62 C
ATOM 443 CD GLU A 64 -23. 452 -43. 687 -30. 274 1 ■ 00 57. 94 C If ATOM 443 CD GLU A 64 -23. 452 -43. 687 -30. 274 1 ■ 00 57. 94 C If
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N L8 '99 00 Z.9L - 380 "Sfr- 908 92- 99 V dy丄 N WOiVN L8 '99 00 Z.9L-380 "Sfr- 908 92- 99 V dy 丄 N WOiV
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0 SL '9S 00 •1· 9 8 '92- 06 - 99 V AID 0 09 WOIV0 SL '9S 00 • 1 9 8 '92-06-99 V AID 0 09 WOIV
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N W39 00 'I QIO'LZ- 063 'Z - Z.6C '5Ζ- 99 V人" 19 N sn WOIVN W39 00 'I QIO' LZ-063 'Z-Z.6C' 5Ζ-99 V people "19 N sn WOIV
0 66 S 00 ■L 966 '53- 66ε - ZO £Z- ½ V ΓΠ9 0 L WOIV0 66 S 00 L 966 '53-66ε-ZO £ Z- ½ V ΓΠ9 0 L WOIV
0 89 Ί9 00 ■L εΖ.6 '92- 980 'W- V ΠΊ9 0 9n WOIV0 89 Ί9 00 L εΖ.6 '92-980 'W- V ΠΊ9 0 9n WOIV
0 00 H f .8 οε- 919 317- LOL Έ2- P9 V ΠΊ3 330 sn WOIV0 00 H f .8 οε- 919 317- LOL Έ2- P9 V ΠΊ3 330 sn WOIV
0 LL '89 00 ■i 989 'οε— 08Z. ん 6 '£Ζ- fr9 V Π19 Lョ 0 WOIV 0 LL '89 00 ■ i 989 'οε— 08Z. 6' £ Ζ- fr9 V Π19 L 0 0 WOIV
SSLlL0/L00Zd£/13d 0CZ.S0/600Z OAV ATOM 480 CA PRO A 69 -26.632 - 41.081 -31.029 1.00 55.13 CSSLlL0 / L00Zd £ / 13d 0CZ.S0 / 600Z OAV ATOM 480 CA PRO A 69 -26.632-41.081 -31.029 1.00 55.13 C
ATOM 481 CB PRO A 69 -26.386 - 40.593 -32.456 1. 00 56.58 CATOM 481 CB PRO A 69 -26.386-40.593 -32.456 1. 00 56.58 C
ATOM 482 CG PRO A 69 -26.950 -41. 670 -33.325 1. 00 56.57 CATOM 482 CG PRO A 69 -26.950 -41. 670 -33.325 1. 00 56.57 C
ATOM 483 C PRO A 69 -27.896 -40.469 -30.421 1. 00 52.83 CATOM 483 C PRO A 69 -27.896 -40.469 -30.421 1. 00 52.83 C
ATOM 484 0 PRO A 69 -29.010 -40.774 -30.845 1. 00 51.43 0ATOM 484 0 PRO A 69 -29.010 -40.774 -30.845 1. 00 51.43 0
ATOM 485 N VAL A 70 -27.705 -39.604 -29.427 1. 00 51.40 ΝATOM 485 N VAL A 70 -27.705 -39.604 -29.427 1. 00 51.40 Ν
ATOM 486 CA VAL A 70 - 28.801 - 38.865 -28.804 1. 00 49.40 CATOM 486 CA VAL A 70-28.801-38.865 -28.804 1. 00 49.40 C
ATOM 487 CB VAL A 70 -29.158 -39.448 -27.424 1. 00 48.73 CATOM 487 CB VAL A 70 -29.158 -39.448 -27.424 1. 00 48.73 C
ATOM 488 CG1 VAL A 70 -30,194 -38. 580 - 26.751 1. 00 48.22 CATOM 488 CG1 VAL A 70 -30,194 -38. 580-26.751 1. 00 48.22 C
ATOM 489 CG2 VAL A 70 - 29.687 - 40. 860 -27.577 1. 00 50.94 CATOM 489 CG2 VAL A 70-29.687-40. 860 -27.577 1. 00 50.94 C
ATOM 490 C VAL A 70 - 28.464 -37. 387 -28.617 1. 00 48.27 CATOM 490 C VAL A 70-28.464 -37. 387 -28.617 1. 00 48.27 C
ATOM 491 .0 VAL A 70 -27. 344 -37. 032 -28.248 1. 00 48.09 0ATOM 491 .0 VAL A 70 -27. 344 -37. 032 -28.248 1. 00 48.09 0
ATOM 492 N 6LU A 71 -29. 439 -36. 521 -28.864 1. 00 46.37 ΝATOM 492 N 6LU A 71 -29. 439 -36. 521 -28.864 1. 00 46.37 Ν
ATOM 493 CA 6LU A 71 -29. 258 - 35. 105 -28.577 1. 00 45.13 CATOM 493 CA 6LU A 71 -29. 258-35. 105 -28.577 1. 00 45.13 C
ATOM 494 CB GLU A 71 -30. 138 -34. 252 -29.484 1. 00 44.85 CATOM 494 CB GLU A 71 -30. 138 -34. 252 -29.484 1. 00 44.85 C
ATOM 495 GG GLU A 71 -29. 465 - 33. 858 -30.776 1. ,00 46.71 CATOM 495 GG GLU A 71 -29. 465-33. 858 -30.776 1., 00 46.71 C
ATOM 496 CD GLU A 71 —29. 696 - 32. 406 -31.117 1. .00 46.51 CATOM 496 CD GLU A 71 —29. 696-32. 406 -31.117 1. .00 46.51 C
ATOM 497 0E1 GLU A 71 -28. 755 - 31. 758 -31.623 1. ,00 45.44 0ATOM 497 0E1 GLU A 71 -28. 755-31. 758 -31.623 1., 00 45.44 0
ATOM 498 0E2 GLU A 71 -30. 821 -31. 917 - 30.875 1. ,00. 47.95 0ATOM 498 0E2 GLU A 71 -30. 821 -31. 917-30.875 1., 00. 47.95 0
ATOM 499 C GLU A 71 -29. 574 -34. 785 -27.126 1. ,00 43.26 CATOM 499 C GLU A 71 -29. 574 -34. 785 -27.126 1., 00 43.26 C
ATOM 500 0 GLU A 71 -30. 614 - 35. 171 - 26.599 1. .00 42.12 0ATOM 500 0 GLU A 71 -30. 614-35. 171-26.599 1. .00 42.12 0
ATOM 501 N ILE A 72 -28. 659 -34. 075 -26.485 1. ,00 41.89 ΝATOM 501 N ILE A 72 -28. 659 -34. 075 -26.485 1., 00 41.89 Ν
ATOM 502 CA ILE A 72 -28. 853 - 33. 649 -25.115 1, .00 41.32 CATOM 502 CA ILE A 72 -28. 853-33. 649 -25.115 1, .00 41.32 C
ATOM 503 CB ILE A 72 - 27. 804 -34. 265 - 24.192 1. .00 41.02 CATOM 503 CB ILE A 72-27. 804 -34. 265-24.192 1. .00 41.02 C
ATOM 504 CG2 ILE A 72 - 27. 987 -35. 769 -24.135 1, .00 CATOM 504 CG2 ILE A 72-27. 987 -35. 769 -24.135 1, .00 C
ATOM 505 Cd1 ILE A 72 -26. 408 - 33. 897 - 24.693 1, .00 39.69 CATOM 505 Cd1 ILE A 72 -26. 408-33. 897-24.693 1, .00 39.69 C
ATOM 506 CD1 ILE A 72 一 25. 305 - 34.250 -23.725 1. .00 41.67 CATOM 506 CD1 ILE A 72 1 25. 305-34.250 -23.725 1. .00 41.67 C
ATOM 507 C ILE A 72 -28. 723 -32. 142 - 25.039 1, .00 CATOM 507 C ILE A 72 -28. 723 -32. 142-25.039 1, .00 C
ATOM 508 0 ILE A 72 -28. 343 -31. 491 -26.012 1, .00 41.33 0ATOM 508 0 ILE A 72 -28. 343 -31. 491 -26.012 1, .00 41.33 0
ATOM 509 N ASP A 73 - 29. 047 -31. 594 -23.875 1, .00 42.40 ΝATOM 509 N ASP A 73-29. 047 -31. 594 -23.875 1, .00 42.40 Ν
ATOM 510 CA ASP A 73 -28. 797 -30. 192 -23.587 1, .00 42.35 CATOM 510 CA ASP A 73 -28. 797 -30. 192 -23.587 1, .00 42.35 C
ATOM 511 CB ASP A 73 - 30. 057 -29. 543 -23.034 1 • 00 44.93 CATOM 511 CB ASP A 73-30. 057 -29. 543 -23.034 1 • 00 44.93 C
ATOM 512 CG ASP A 73 -31. 209 -29. 608 -24.005 1 .00 48.44 CATOM 512 CG ASP A 73 -31. 209 -29. 608 -24.005 1 .00 48.44 C
ATOM 513 0D1 ASP A 73 -32. 077 -30. 494 -23.841 1 .00 50.51 0ATOM 513 0D1 ASP A 73 -32. 077 -30. 494 -23.841 1 .00 50.51 0
ATOM 514 0D2 ASP A 73 -31. 243 -28. 772 -24.932 1 • 00 49.64 0ATOM 514 0D2 ASP A 73 -31. 243 -28. 772 -24.932 1 • 00 49.64 0
ATOM 515 C ASP A 73 一 27. 679 -30. 108 -22.565 1 .00 41.26 C ATOM 516 0 ASP A 73 -27.459 -31.048 -21.808 1.00 42.29 0ATOM 515 C ASP A 73 1 27. 679 -30. 108 -22.565 1 .00 41.26 C ATOM 516 0 ASP A 73 -27.459 -31.048 -21.808 1.00 42.29 0
ATOM 517 N GLN A 74 -26.973 - 28.986 -22.540 1. 00 39.93 NATOM 517 N GLN A 74 -26.973-28.986 -22.540 1. 00 39.93 N
ATOM 518 CA GLN A 74 - 25.827 - 28.847 -21.656 1. 00 39.95 CATOM 518 CA GLN A 74-25.827-28.847 -21.656 1. 00 39.95 C
ATOM 519 CB GLN A 74 -24.622 -29.584 - 22.246 1. 00 42.01 CATOM 519 CB GLN A 74 -24.622 -29.584-22.246 1. 00 42.01 C
ATOM 520 CG GLN A 74 -24.074 -28.943 -23,511 1. 00 45.96 CATOM 520 CG GLN A 74 -24.074 -28.943 -23,511 1. 00 45.96 C
ATOM 521 CD GLN A 74 - 22.763 -29.557 -23.959 1. 00 49.03 CATOM 521 CD GLN A 74-22.763 -29.557 -23.959 1.00 49.03 C
ATOM 522 0E1 GLN A 74 - 22.495 -30.733 - 23.704 1. 00 52.59 0ATOM 522 0E1 GLN A 74-22.495 -30.733-23.704 1. 00 52.59 0
ATOM 523 NE2 GLN A 74 -21. 936 -28.763 - 24.632 1. 00 48.94 NATOM 523 NE2 GLN A 74 -21.936 -28.763-24.632 1.00 48.94 N
ATOM 524 C GLN A 74 - 25.475 -27.379 - 21■ 463 1. 00 37.86 CATOM 524 C GLN A 74-25.475 -27.379-21 ■ 463 1. 00 37.86 C
ATOM 525 0 GLN A 74 -25. 702 -26.555 -22.343 1. 00 37.16 0ATOM 525 0 GLN A 74 -25. 702 -26.555 -22.343 1. 00 37.16 0
ATOM 526 N ILE A 75 -24. 920 - 27.056 -20.304 1. 00 36.39 NATOM 526 N ILE A 75 -24. 920-27.056 -20.304 1. 00 36.39 N
ATOM 527 CA ILE A 75 -24. 412 -25.7.18 -20.070 1. 00 36. 15 CATOM 527 CA ILE A 75 -24. 412 -25.7.18 -20.070 1. 00 36. 15 C
ATOM 528 CB ILE A 75 -24. 939 - 25.141 -18.756 1. 00 35. 21 . CATOM 528 CB ILE A 75 -24. 939-25.141 -18.756 1. 00 35. 21.
ATOM 529 CG2 ILE A 75 -26. 441 -25.280 -18.700 1. 00 36. 30 CATOM 529 CG2 ILE A 75 -26. 441 -25.280 -18.700 1. 00 36. 30 C
ATOM 530 CG1 ILE A 75 -24. 310 - 25.878 -17.577 1. 00 36. 75 CATOM 530 CG1 ILE A 75 -24. 310-25.878 -17.577 1. 00 36. 75 C
ATOM 531 CD1 ILE A 75 -24. 472 -25.159 -16.255 1. 00 38. 59 CATOM 531 CD1 ILE A 75 -24. 472 -25.159 -16.255 1. 00 38. 59 C
ATOM 532 C ILE A 75 - 22. 897 -25.806 -19.983 1. 00 36. 01 CATOM 532 C ILE A 75-22. 897 -25.806 -19.983 1.00 36. 01 C
ATOM 533 0 ILE A 75 -22. 358 - 26.822 -19.553 1. ,00 35. 52 0ATOM 533 0 ILE A 75 -22. 358-26.822 -19.553 1., 00 35. 52 0
ATOM 534 N LYS A 76 -22. 216 -24.746 -20.399 1. 00 35. 65 NATOM 534 N LYS A 76 -22. 216 -24.746 -20.399 1. 00 35. 65 N
ATOM 535 CA LYS A 76 -20. 768 -24.686 -20.280 1. 00 36. 79 CATOM 535 CA LYS A 76 -20. 768 -24.686 -20.280 1. 00 36. 79 C
ATOM 536 CB LYS A 76 - 20. 177 -23.673 -21.272 1. ,00 40. 99 CATOM 536 CB LYS A 76-20. 177 -23.673 -21.272 1., 00 40. 99 C
ATOM 537 C6 LYS A 76 -20. 655 -23.824 -22.710 1. 00 43. 76 CATOM 537 C6 LYS A 76 -20. 655 -23.824 -22.710 1. 00 43. 76 C
ATOM 538 CD LYS A 76 -19. 955 -24.973 -23.411 1. ,00 47. 13 CATOM 538 CD LYS A 76 -19. 955 -24.973 -23.411 1., 00 47. 13 C
ATOM 539 CE LYS A 76 -19. 119 -24.469 - 24.573 1. ,00 48. 11 CATOM 539 CE LYS A 76 -19. 119 -24.469-24.573 1., 00 48. 11 C
ATOM 540 NZ LYS A 76 -18. 012 - 23.589 -24.098 1. .00 51. 53 NATOM 540 NZ LYS A 76 -18. 012-23.589 -24.098 1. .00 51. 53 N
ATOM 541 C LYS A 76 -20. 440 -24.246 -18.866 1. ,00 35. 60 CATOM 541 C LYS A 76 -20. 440 -24.246 -18.866 1., 00 35. 60 C
ATOM 542 0 LYS A 76 -20. 296 -23.049 -18.602 1. .00 34. 46 0ATOM 542 0 LYS A 76 -20. 296 -23.049 -18.602 1. .00 34. 46 0
ATOM 543 N GLY A 77 -20. 321 -25.216 - 17.965 1. .00 34. 61 NATOM 543 N GLY A 77 -20. 321 -25.216-17.965 1. .00 34. 61 N
ATOM 544 CA GLY A 77 -20. 018 -24.905 -16.582 1. .00 32. 82 CATOM 544 CA GLY A 77 -20. 018 -24.905 -16.582 1. .00 32. 82 C
ATOM 545 C GLY A 77 -18. 857 -23.940 -16.453 1. .00 31. 97 GATOM 545 C GLY A 77 -18. 857 -23.940 -16.453 1. .00 31. 97 G
ATOM 546 0 GLY A 77 -18. 889 - 23.024 -15.634 1, .00. 31. 89 0ATOM 546 0 GLY A 77 -18. 889-23.024 -15.634 1, .00. 31. 89 0
ATOM 547 N LYS A 78 - 17. 835 -24.135 -17.275 1, .00 31. 88 NATOM 547 N LYS A 78-17. 835 -24.135 -17.275 1, .00 31. 88 N
ATOM 548 CA LYS A 78 -16. 643 - 23· 300 -17.216 1, .00 32. 97 CATOM 548 CA LYS A 78 -16. 643-23.300 -17.216 1, .00 32. 97 C
ATOM 549 CB LYS A 78 -15. 607 -23.789 -18.232 1, .00 33. 89 CATOM 549 CB LYS A 78 -15. 607 -23.789 -18.232 1, .00 33. 89 C
ATOM 550 CG LYS A 78 -16. 033 - 23.596 - 19.682 1 .00 38. 47 CATOM 550 CG LYS A 78 -16. 033-23.596-19.682 1 .00 38. 47 C
ATOM 551 CD LYS A 78 -15. 090 -24.302一 20.660 1, .00 41. 69 C ATOM 552 CE LYS A 78 - 15.646 - 24.274 -22.091 1.0042.26 CATOM 551 CD LYS A 78 -15. 090 -24.302 One 20.660 1, .00 41. 69 C ATOM 552 CE LYS A 78-15.646-24.274 -22.091 1.0042.26 C
ATOM 553 NZ LYS A 78 -14.931 -25. 214 -23.008 1. 00 43. 50 NATOM 553 NZ LYS A 78 -14.931 -25. 214 -23.008 1. 00 43. 50 N
ATOM 554 C LYS A 78 -16.963 -21. 825 -17.472 1. 00 32. 86 CATOM 554 C LYS A 78 -16.963 -21. 825 -17.472 1. 00 32. 86 C
ATOM 555 0 LYS A 78 - 16.171 -20. 949 -17.140 1. 00 35. 72 0ATOM 555 0 LYS A 78-16.171 -20. 949 -17.140 1. 00 35. 72 0
ATOM 556 N LYS A 79 -18.120 -21. 544 - 18.057 1. 00 31. 60 NATOM 556 N LYS A 79 -18.120 -21. 544-18.057 1. 00 31. 60 N
ATOM 557 CA LYS A 79 -18.489 -20. 162 -18.348 1. 00 31. 69 CATOM 557 CA LYS A 79 -18.489 -20. 162 -18.348 1. 00 31. 69 C
ATOM 558 CB LYS A 79 -19.139 -20. 090 -19.731 1. 00 32. 68 CATOM 558 CB LYS A 79 -19.139 -20. 090 -19.731 1. 00 32. 68 C
ATOM 559 CG LYS A 79 -18.151 -20. 380 -20.859 1. 00 36. 58 CATOM 559 CG LYS A 79 -18.151 -20. 380 -20.859 1. 00 36. 58 C
ATOM 560 CD LYS A 79 - 18.827 -20. 513 -22.213 1. 00 39. 42 CATOM 560 CD LYS A 79-18.827 -20. 513 -22.213 1. 00 39. 42 C
ATOM 561 CE LYS A 79 -17.797 -20. 495 - 23.334 1. 00 41. 58 CATOM 561 CE LYS A 79 -17.797 -20. 495-23.334 1. 00 41. 58 C
ATOM 562 NZ LYS A 79 -16.544 -21. 222 -22.962 1. 00 42. 84 NATOM 562 NZ LYS A 79 -16.544 -21. 222 -22.962 1. 00 42. 84 N
ATOM 563 C LYS A 79 -19.400 -19. 546 -17.275 1. 00 30. 56 CATOM 563 C LYS A 79 -19.400 -19. 546 -17.275 1. 00 30. 56 C
ATOM 564 0 LYS A 79 -19.992 -18. 481 -17.471 1. 00 28. 15 0ATOM 564 0 LYS A 79 -19.992 -18. 481 -17.471 1. 00 28. 15 0
ATOM 565 N ILE A 80 -19.501 -20. 234一 16.140 1. 00 29. 22 NATOM 565 N ILE A 80 -19.501 -20. 234 1 16.140 1. 00 29. 22 N
ATOM 566 CA ILE A 80 -20.082 -19. 668 -1 .923 1. 00 28. 58 CATOM 566 CA ILE A 80 -20.082 -19. 668 -1 .923 1. 00 28. 58 C
ATOM 567 CB ILE A 80 -20.965 -20. 709一 14.202 1. 00 26. 76 CATOM 567 CB ILE A 80 -20.965 -20. 709 One 14.202 1. 00 26. 76 C
ATOM 568 CG2 ILE A 80 - 21.605 -20. 094 -12.961 1. 00 27. 01 CATOM 568 CG2 ILE A 80-21.605 -20. 094 -12.961 1.00 27. 01 C
ATOM 569 CG1 ILE A 80 -22.025 -21. 235 -15.162 1. 00 27. 16 CATOM 569 CG1 ILE A 80 -22.025 -21. 235 -15.162 1. 00 27. 16 C
ATOM 570 CD1 ILE A 80 -22.960 -20. 176 -15.687 1. 00. 27. 66 CATOM 570 CD1 ILE A 80 -22.960 -20. 176 -15.687 1. 00. 27. 66 C
ATOM 571 C ILE A 80 -18.916 -19. 302 -14.005 1. 00 27. 51 CATOM 571 C ILE A 80 -18.916 -19. 302 -14.005 1. 00 27. 51 C
ATOM 572 0 ILE A 80 -17.907 -20. 010 -13.982 1. ,00 28. 34 0ATOM 572 0 ILE A 80 -17.907 -20. 010 -13.982 1., 00 28. 34 0
ATOM 573 N THR A 81 -19.034 -18. 205 -13.262 1. 00 26. 80 NATOM 573 N THR A 81 -19.034 -18. 205 -13.262 1. 00 26. 80 N
ATOM 574 CA THR A 81 -17.999 - 17. 863 -12.281 1. ,00 28. 93 CATOM 574 CA THR A 81 -17.999-17. 863 -12.281 1., 00 28. 93 C
ATOM 575 CB THR A 81 -17.198一 16. 598 -12.669 1. ,00 29. 63 CATOM 575 CB THR A 81 -17.198 1 16. 598 -12.669 1., 00 29. 63 C
ATOM 576 061 THR A 81 -16.523 -16. 805 -13.916 1. .00 32. 24 0ATOM 576 061 THR A 81 -16.523 -16. 805 -13.916 1. .00 32. 24 0
ATOM 577 Cfi2 THR A 81 -16.151 -16. 306 -11 · 603 1. ,00 29. 68 CATOM 577 Cfi2 THR A 81 -16.151 -16. 306 -11 · 603 1., 00 29. 68 C
ATOM 578 C THR A 81 -18.541 -17. 634 -10.879 1. .00 29. 10 CATOM 578 C THR A 81 -18.541 -17. 634 -10.879 1. .00 29. 10 C
ATOM 579 0 THR A 81 -19.475一 16. 860 -10.675 1. .00 28. 57 0ATOM 579 0 THR A 81 -19.475 1 16. 860 -10.675 1. .00 28. 57 0
ATOM 580 N VAL A 82 -17.933 -18. 311 -9.912 1. .00 28. 32 NATOM 580 N VAL A 82 -17.933 -18. 311 -9.912 1. .00 28. 32 N
ATOM 581 CA VAL A 82 -18.296 -18. 133 - 8.524 1, .00 28. 28 CATOM 581 CA VAL A 82 -18.296 -18. 133-8.524 1, .00 28. 28 C
ATOM 582 CB VAL A 82 -18.157 -19. 429 -7.734 1, .00 27. 48 CATOM 582 CB VAL A 82 -18.157 -19. 429 -7.734 1, .00 27. 48 C
ATOM 583 CG1 VAL A 82 -18.709 -19. 232 -6.338 1, .00 28. 48 CATOM 583 CG1 VAL A 82 -18.709 -19. 232 -6.338 1, .00 28. 48 C
ATOM 584 CG2 VAL A 82 -18.889 -20. 537 一 8.444 1, .00 33. 27 CATOM 584 CG2 VAL A 82 -18.889 -20. 537 One 8.444 1, .00 33. 27 C
ATOM 585 C VAL A 82 -17.384 - 17. 098 -7.901 1 .00 27. 55 CATOM 585 C VAL A 82 -17.384-17. 098 -7.901 1 .00 27. 55 C
ATOM 586 0 VAL A 82 -16.161 -17. 223 -7.946 1, .00 27. 64 0ATOM 586 0 VAL A 82 -16.161 -17. 223 -7.946 1, .00 27. 64 0
ATOM 587 N VAL A 83 —17.987 -16. 077 一 7, 310 1 .00 25. 94 N s ATOM 587 N VAL A 83 —17.987 -16. 077 One 7, 310 1 .00 25. 94 N s
0 98 "9300 " I SZL ■6 888 ■SL- 6LZ ■SL- Z.8 V 9¾V zo £Z9 隱 V 0 98 "9300" I SZL ■ 6 888 ■ SL-6LZ ■ SL- Z.8 V 9¾V zo £ Z9 隱 V
N 69 -gz 00 ' I 08fr "8 0Z.fr ■£1- 690 ■SL- Z.8 V 9W 3N ZZ9 WO丄 VN 69 -gz 00 'I 08fr "8 0Z.fr ■ £ 1- 690 ■ SL- Z.8 V 9W 3N ZZ9 WO 丄 V
0 9ε ' oo ' I 909 066 Ι- 6L0 ■21- Z.8 V 9MV GO 129 INOIV0 9ε 'oo' I 909 066 Ι-6L0 21- Z.8 V 9MV GO 129 INOIV
0 9 οι2 "9300 " I m ■9 669 ■SL- ιοε '21- Z.8 V 9W DO 029 WO丄 V0 9 οι2 "9300" I m ■ 9 669 ■ SL- ιοε '21-Z.8 V 9W DO 029 WO 丄 V
0 6ん εζ 00 oo ' I P8L "9 S91 ■ρι- S69 ■SL - L8 V oyv 90 619 W01V0 6 εζ 00 oo 'I P8L "9 S91 ■ ρι- S69 ■ SL-L8 V oyv 90 619 W01V
0 83 00 ο ' I Ll£ 086 τι- 380 L- Z.8 V VO 8L9 INOIV0 83 00 ο 'I Ll £ 086 τι- 380 L- Z.8 V VO 8L9 INOIV
N 30 '9Ζ 001 I ZIO 5 τι- 982 ■ - Z.8 V N L19 INOIVN 30 '9Ζ 00 1 I ZIO 5 τι- 982 ■-Z.8 VN L19 INOIV
0 11 ·9Ζ 00' l W)S Ζ ΖΖ6 ΌΙ- 98 V nai 0 9L9 INOIV0 11 · 9Ζ 00 'l W) S Ζ ΖΖ6 ΌΙ- 98 V nai 0 9L9 INOIV
0 36 n 00 ' l L 'τ 960 ■21- 61Ζ i- 98 V Π3Ί 0 SL9 W01V0 36 n 00 'l L' τ 960 21-61Ζ i- 98 V Π3Ί 0 SL9 W01V
0 96 ·εε οο ' l ZVv Ό 893 '9L- 60 "31- 98 V Π31 L9 W01V0 96 · εε οο 'l ZVv Ό 893' 9L- 60 "31- 98 V Π31 L9 W01V
0 l USL 0 9S9 ■SL- 2iZ Όί- 98 V Π3Ί iqo εΐ9 W01V0 l USL 0 9S9 SL-2iZ Όί- 98 V Π3Ί iqo εΐ9 W01V
0 2 εε οο■ l οοε 0 18L ■ει - IZL ■LL - 98 V Π31 DO 2L9 WO丄 V0 2 εε οο ■ l οοε 0 18L ■ ει-IZL ■ LL-98 V Π31 DO 2L9 WO 丄 V
0 LZ 'οε οο l "L 9W) ει- τι- 98 V Π31 ao U9 W01V0 LZ 'οε οο l "L 9W) ει- τι- 98 V Π31 ao U9 W01V
0 89 '9Ζ 00 L LZ.9 Μ 9Ζ.0 ■SL- ■ει- 98 V Π3Ί vo 0L9 INOIV0 89 '9Ζ 00 L LZ.9 Μ 9Ζ.0 SL- ■ ει- 98 V Π3Ί vo 0L9 INOIV
N η 'η οο L 5Z •0 S69 ■ζι~ OLS ■n- 98 V Πョ Ί N 609 W01VN η 'η οο L 5Z • 0 S69 ■ ζι ~ OLS ■ n- 98 V Π Ί N 609 W01V
0 ί9 '9300 ■I 013■L 380 -ει- 9Ζ.9 ■9L- 98 V 311 0 809 INOIV0 ί9 '9300 ■ I 013 L 380 -ει- 9Ζ.9 ■ 9L- 98 V 311 0 809 INOIV
0 οο ~η οο ■i 60S•0 Z0L ■31- f 8 ■SL- 98 V 311 0 ん 09 INOIV0 οο ~ η οο ■ i 60S • 0 Z0L ■ 31- f 8 ■ SL- 98 V 311 0 09 09 INOIV
0 6ε ζζ οο -L 90 Z- 169 .6 - 960 ■61- S8 V 311 100 909 WO丄 V0 6ε ζζ οο -L 90 Z- 169.6-960 61- S8 V 311 100 909 WO 丄 V
0 9L ' 00 'L 9t4 - 299 ■01·- 910 "81- 98 V 311 L90 S09 W01V0 9L '00' L 9t4-299 01-910 "81-98 V 311 L90 S09 W01V
0 ΖΖ ΌΖ 00 Λ ZL0 Ό - 8L6 ■6 - 8SL '9L- 98 V 311 ZdO t-09 INOIV0 ΖΖ ΌΖ 00 Λ ZL0 Ό-8L6 ∎ 6-8SL '9L- 98 V 311 ZdO t-09 INOIV
0 W Z 00 ■I S6 Ό- 360 ■ιι- 6ZP ' l - 98 V 311 go 909 WO丄 V0 W Z 00 ■ I S6 360- 360 ■ ιι- 6ZP 'l-98 V 311 go 909 WO 丄 V
0 2^Έ200 'L 830 ' L- 9ΖΖ τν~ 60P ■9L- 98 V 311 vo 209 INOIV0 2 ^ Έ200 'L 830' L- 9ΖΖ τν ~ 60P 9L- 98 V 311 vo 209 INOIV
N 28 £Ζ 00 L 089 - L- S9S τι- Z90 ■a- S8 V 311 N 1.09 WO丄 VN 28 £ Ζ 00 L 089-L- S9S τι- Z90 a- S8 V 311 N 1.09 WO 丄 V
0 6 ΖΖ 00 ■I ειο ε- 6S8 ■ει- 91S ■9L- V Oild 0 009 INOIV0 6 ΖΖ 00 ■ I ειο ε- 6S8 ■ ει- 91S ■ 9L- V Oild 0 009 INOIV
0 'τι οο Ί L99 'Ζ- 9ΖΙ ■η- 9 IP ■91- V 0¾d 0' 669 W01V0 'τι οο Ί L99' Ζ- 9ΖΙ ■ η- 9 IP ■ 91- V 0¾d 0 '669 W01V
0 9£ £Ζ 00 98 ·ε - £30 L- €8P 'SL- V oyd 90 86S WO丄 V0 9 £ £ Ζ 00 98 · ε-£ 30 L- € 8P 'SL- V oyd 90 86S WO 丄 V
0 30 'ΖΖ 00 t-ef 'τ - 9^9 ■9L- 09P '91- V oy<d ao Z.69 INOIV0 30 'ΖΖ 00 t-ef' τ-9 ^ 9 9L- 09P '91-V oy <d ao Z.69 INOIV
0 26 'ΖΖ 00 εοο ·ε- Q6S ■9L- 621 ■Z.L- V oyd vo 969 WO丄 V0 26 'ΖΖ 00 εοοε- Q6S 9L-621 Z.L- V oyd vo 969 WO 丄 V
0 ε τζ οο Λ 018 一 S89 ■91- III -9L- V o«d ao 969 INOIV0 ε τζ οο Λ 018 1 S89 ■ 91- III -9L- V o «d ao 969 INOIV
N η £ζ οο Λ - - 0L5 ■SL- ZIO 'LY- V o¾y N t-69 INOIVN η £ ζ οο Λ--0L5SL- ZIO 'LY- V o¾y N t-69 INOIV
0 ί£ '5Ζ 00 ■L 966 - - 606 ■SL - SZP •8L- 88 V 1VA 0 £69 WO丄 V0 ί £ '5Ζ 00 ■ L 966--606 ■ SL-SZP • 8L- 88 V 1VA 0 £ 69 WO 丄 V
〇 36X300 L££ '9- 09 - l- 909 'ん L - S8 V VA 0 269 INOIV〇 36X300 L ££ '9- 09-l- 909' L-S8 V VA 0 269 INOIV
0 09 ·ττ οο ■L 680 ·6- LZ6 ■εΐ·- εοε "Z.L- S8 V 1VA 3D0 L6S INOIV0 09 · ττ οοL 680 · 6- LZ6 εΐ ·-εοε "Z.L- S8 V 1VA 3D0 L6S INOIV
0 0L '6100 'L ^Zl 'んー ΖΖ2 ■21- 369 '91 - S8 V 1VA 190 06S WO丄 V0 0L '6100' L ^ Zl 'N-ΖΖ2 21-369 '91-S8 V 1VA 190 06S WO 丄 V
0 ε 'ζζ οο •L 909 'ん - L9 ■ει- IP9 'a- S8 V 1VA ao 689 匪 V0 ε 'ζζ οο L 909' N-L9ει- IP9 'a- S8 V 1VA ao 689 匪 V
0 OS 00 ■L L6L '9- 9S6 ■VI- 6ZZ •U - 8 V 1VA vo 889 INOIV 0 OS 00 ■ L L6L '9-9S6 ■ VI-6ZZ • U-8 V 1VA vo 889 INOIV
££/.I/.0/Z,00Zdf/X3d 9 ££ / .I / .0 / Z, 00Zdf / X3d 9
0 98 93 00' L 8οε τ - Ζ.εθ"12- 293'Z.L- S6 V丄ョ IN ao 699 1N01V 0 98 93 00 'L 8οε τ-Ζ.εθ "12- 293'Z.L- S6 V 丄 IN ao 699 1N01V
0 ½ ■n oo■ L 5zz ·τ- ΥΖΖ Ζ- τし L "8L- 86 V 13W o 839 INOIV0 ½ ■ n oo ■ L 5zz · τ- ΥΖΖ Ζ- τ L "8L- 86 V 13W o 839 INOIV
N 9ん ■εζ oo' 1. 9εο ι- 688 ·0Ζ- 99 '6 L- S6 V丄ョ W N L29 W01VN 9 ん εζ oo '1. 9εο ι- 688 · 0Ζ- 99' 6 L- S6 V 丄 yo W N L29 W01V
0 LZ ■iz 00' L εο£-ι- PES ΊΖ- LOfr -1.2- 26 V丄ョ W 0 9S9 WOiV0 LZ iz 00 'L εο £ -ι- PES ΊΖ- LOfr -1.2- 26 V 丄 yo W 0 9S9 WOiV
D 99 ■zz 00' L 898 Ό- LL9 -0Z- Z6 V丄ョ IN 〇 999 WOIVD 99 zz 00 'L 898 Ό-LL9 -0Z- Z6 V 丄 yo IN ○ 999 WOIV
0 98 ■81 00' I ΙΡΟ Ό- ns'a— PZO SZ- 36 V 13W ½9 WOIV0 98 ■ 81 00 'I ΙΡΟ Ό- ns'a— PZO SZ- 36 V 13W ½9 WOIV
S 89 ■£Z 00' I ん 'L ε91 "Z.L- L9L -£Z- . 36 V law as SS9 WOIVS 89 £ Z 00 'I' L ε91 "Z.L- L9L-£ Z-. 36 V law as SS9 WOIV
0 6Z. ΊΖ 00' L on'i 60881- εοο τζ- 36 V 13W 90 399 WOIV0 6Z. ΊΖ 00 'L on'i 60881- εοο τζ- 36 V 13W 90 399 WOIV
0 9ε ■£Z 00' L 09 L Ό Z '61- 99 L ' - 36 V 13W ao L99 INOIV0 9ε £ Z 00 'L 09 L Ό Z '61-99 L'-36 V 13W ao L99 INOIV
0 O ZZ 00' L οη ο 38fr 03- S9Z ' 13- 26 V丄ョ IN vo 099 WOIV0 O ZZ 00 'L οη ο 38fr 03- S9Z' 13- 26 V 丄 IN vo 099 WOIV
N ん ZZ 00 l ZL£'l ν 'οζ - 0L3O3- 36 V丄ョ IN . N 6fr9 WOIVN ZZ 00 l ZL £ 'l ν' οζ-0L3O3- 36 V 丄 yo IN. N 6fr9 WOIV
0 62 92 00 l 09L 'Ζ 828 " L2-ん S9 02- 16 V人" 19 0 8^9 WOIV0 62 92 00 l 09L 'Ζ 828 "L2-N S9 02-16 V people" 19 0 8 ^ 9 WOIV
0 00 I 18^ Ζ 608 Ό3- 90002- L6 V λ19 0 m INOIV0 00 I 18 ^ Ζ 608 Ό3- 90002- L6 V λ19 0 m INOIV
〇 00 00 8 ε 8820Ζ- 86 '8— L6 V人 ΊΕ) vo WOIV〇 00 00 8 ε 8820 86-86 '8— L6 V ΊΕ) vo WOIV
N 90 n 00 I WL Z οζε "6 L- 9908 L- 16 V人 9 N 9^9 WOIVN 90 n 00 I WL Z οζε "6 L- 9908 L- 16 V people 9 N 9 ^ 9 WOIV
0 ι Ό3 00 Ί 829 -L 0乙 80Ζ- ZWLl- 06 V Π31 0 INOIV0 ι Ό3 00 Ί 829 -L 0 O 80 Ζ- ZWLl- 06 V Π31 0 INOIV
0 6ん ' 00 I fr06 L ειζ."6ΐ-ん 'ん L- 06 V Πョ Ί 0 WOIV0 6 '00 I fr06 L ειζ. "6ΐ-' L- 06 V Π Ί 0 WOIV
0 £L '63 00 L ΙΖΟ Ό- ΟΖ.9'61- Z.06 'SL- 06 V Π3Ί ZQO zn WOIV0 £ L '63 00 L ΙΖΟ Ό- ΟΖ. 9'61- Z.06 'SL- 06 V Π3Ί ZQO zn WOIV
0 6 '62 00 ΖΙ Ζ 09L -6L- SZ9 'ΖΙ- 06 V Π31 IQO m OIV0 6 '62 00 ΖΙ Ζ 09L -6L- SZ9 'ΖΙ- 06 V Π31 IQO m OIV
0 O ■ιε 00 'L ΪΖΖ 006 '81.- εο9 -ει- 06 V Π31 90 0^9 WOiV0 Oιι 00 'L ΪΖΖ 006 '81 .- εο9 -ει- 06 V Π31 90 0 ^ 9 WOiV
0 6V9Z 00 ■I Η Ζ 82L "81- 188 · - 06 V Π31 ao 6S9 WOIV0 6V9Z 00 I Η Ζ 82L "81-188 ·-06 V Π31 ao 6S9 WOIV
0 01 wvz 00 ■I· 08 L m '8L- 003 '9L- 06 V Πョ Ί vo 8S9 INOIV0 01 w vz 00 I 08 L m '8L- 003' 9L- 06 V Π vo vo 8S9 INOIV
N 99 ZZ 00 "l 9LS.L S8ん' 9L - 06 V Π3Ί N LZ9 INOIVN 99 ZZ 00 "l 9LS.L S8 '9L-06 V Π3Ί N LZ9 INOIV
0 00 "L 9Ζ.00 .6WZ.L- 68 V AID 0 989 WOIV0 00 "L 9Ζ.00 .6WZ.L- 68 V AID 0 989 WOIV
0 00 Ί 098 ·0 1.86 9L- 388 'Ζ. L- 68 V人， 9 0 2£9 1N01V0 00 Ί 098 · 0 1.86 9L- 388 'Ζ. L- 68 V person, 9 0 2 £ 9 1N01V
0 oo 'ττ 00 H 801 'Ι 96 '91- 68 V kl9 vo n9 INOIV0 oo 'ττ 00 H 801' Ι 96 '91-68 V kl9 vo n9 INOIV
N 90 00 "l 18 Ζ L90'9L- 900 '8L- 68 V人つ 9 N εεθ WOIVN 90 00 "l 18 Ζ L90'9L- 900 '8L- 68 V per person 9 N εεθ WOIV
0 00 -L 8½·ε 828 91- ん -8L- 88 V V，V 0 9 WOIV0 00 -L 8½ · ε 828 91- -8L- 88 V V, V 0 9 WOIV
0 6 00 "L ζ.09'ε KL -9L- 881 8L- 88 V V1V 0 ιε9 WOIV0 6 00 "L ζ.09'ε KL -9L- 881 8L- 88 V V1V 0 ιε9 WOIV
0 ZL ·ττ 00 "L 0 ' S 983 'VI- 8W8L- 88 V V V ao 0S9 WOIV0 ZL ττ 00 "L 0 'S 983' VI-8W8L- 88 V V V ao 0S9 WOIV
〇 06 '22 00 ■L εβζ. - 101.SL- m -Li- 88 V V，V vo 639 INOiV○ 06 '22 00 ■ L εβζ.-101.SL- m -Li- 88 V V, V vo 639 INOiV
N Zl ZZ 00 Ί Ζ55 S9Z ·ΡΙ- 88 V V1V N 839 WOIVN Zl ZZ 00 Ί Ζ55 S9Z ΡΙ- 88 V V1V N 839 WOIV
0 00 'L 6ε8"91- ん 8 V 9HV 0 LZ9 WOIV0 00 'L 6ε8 ”91- 8 V 9HV 0 LZ9 WOIV
0 Z0 Z 00 't 090 ' 08 ^Ι- S '51·— 8 V DMV 0 939 WOIV0 Z0 Z 00 't 090' 08 ^ Ι- S '51 · — 8 V DMV 0 939 WOIV
N L9 9Z 00 ■t on · - ん 8 V D¾V ZHN 939 WOIVN L9 9Z 00 t on ·-8 V D¾V ZHN 939 WOIV
N 89 '93 00 ■L 9W0L 0^8 L- Z.8 V 9MV ίΗΝ f39 INOIV N 89 '93 00 L 9W0L 0 ^ 8 L- Z.8 V 9MV ίΗΝ f39 INOIV
^LlLO/LOOZdT/lDd 0CZZ.S0/600Z ΟΛΧ ATOM 660 C6 MET A 93 -16.586 - 21.343 -3.655 1.00 25.26 C^ LlLO / LOOZdT / lDd 0CZZ.S0 / 600Z ΟΛΧ ATOM 660 C6 MET A 93 -16.586-21.343 -3.655 1.00 25.26 C
ATOM 661 SD MET A 93 -14.812 -21. 042 -3.671 1. 00 29.36 SATOM 661 SD MET A 93 -14.812 -21. 042 -3.671 1. 00 29.36 S
ATOM 662 CE MET A 93 -14.240 -22.165 -2.397 1. 00 24.93 CATOM 662 CE MET A 93 -14.240 -22.165 -2.397 1. 00 24.93 C
ATOM 663 G MET A 93 -19.099 -22.646 -2.742 1. 00 24.84 CATOM 663 G MET A 93 -19.099 -22.646 -2.742 1. 00 24.84 C
ATOM 664 0 MET A 93 -19.531 - 22.878 -3.871 1. 00 26.55 0ATOM 664 0 MET A 93 -19.531-22.878 -3.871 1.00 26.55 0
ATOM 665 N ASP A 94 -18.902 -23.596 - 1.832 1. 00 24.40 NATOM 665 N ASP A 94 -18.902 -23.596-1.832 1. 00 24.40 N
ATOM 666 CA ASP A 94 -19.093 -25.007 -2.157 1. 00 24.67 CATOM 666 CA ASP A 94 -19.093 -25.007 -2.157 1.00 24.67 C
ATOM 667 CB ASP A 94 -18.713 - 25. 897 -0.971 1. 00 23.34 CATOM 667 CB ASP A 94 -18.713-25. 897 -0.971 1. 00 23.34 C
ATOM 668 GG ASP A 94 -17. 233 -26. 229 -0.946 1. 00 26.81 CATOM 668 GG ASP A 94 -17. 233 -26. 229 -0.946 1. 00 26.81 C
ATOM 669 0D1 ASP A 94 -16.549 - 25. 980 - 1.964 1. 00 28.21 0ATOM 669 0D1 ASP A 94 -16.549-25. 980-1.964 1. 00 28.21 0
ATOM 670 0D2 ASP A 94 -16. 747 -26. 740 0.086 1. 00 25.81 0ATOM 670 0D2 ASP A 94 -16. 747 -26. 740 0.086 1. 00 25.81 0
ATOM 671 C ASP A 94 -20. 516 - 25. 313 -2.585 1. 00 25.46 CATOM 671 C ASP A 94 -20. 516-25. 313 -2.585 1. 00 25.46 C
ATOM 672 0 ASP A 94 -20. 738 - 26. 128 - 3.478 1. 00 27. 05 0ATOM 672 0 ASP A 94 -20. 738-26. 128-3.478 1. 00 27. 05 0
ATOM 673 N GLY A 95 -21. 479 -24. 658 -1.948 1. 00 26. 96 NATOM 673 N GLY A 95 -21.479 -24.658 -1.948 1.00 26.96 N
ATOM 674 CA 6LY A 95 - 22. 867一 24. 870 -2.312 1. 00 26. 69 CATOM 674 CA 6LY A 95-22. 867 1 24. 870 -2.312 1. 00 26. 69 C
ATOM 675 C GLY A 95 -23. 121 - 24. 501 -3.761 1. 00 26. 31 CATOM 675 C GLY A 95 -23. 121-24. 501 -3.761 1. 00 26. 31 C
ATOM 676 0 GLY A 95 - 23. 942 -25. 129 -4.435 1. 00 25. 87 0ATOM 676 0 GLY A 95-23. 942 -25. 129 -4.435 1. 00 25. 87 0
ATOM 677 N VAL A 96 - 22. 412 -23. 487 -4.250 1. ,00 24. 40 NATOM 677 N VAL A 96-22. 412 -23. 487 -4.250 1., 00 24. 40 N
ATOM 678 CA VAL A 96 -22. 540 -23. 106 - 5.646 1. 00 23. 75 CATOM 678 CA VAL A 96 -22. 540 -23. 106-5.646 1. 00 23. 75 C
ATOM 679 CB VAL A 96 -21. 923 - 21. 719 - 5.909 1. 00 25. 35 CATOM 679 CB VAL A 96 -21. 923-21. 719-5.909 1. 00 25. 35 C
ATOM 680 C61 VAL A 96 - 22. 189 -21. 305 -7.340 1. ,00 23. 59 CATOM 680 C61 VAL A 96-22. 189 -21. 305 -7.340 1., 00 23. 59 C
ATOM 681 CG2 VAL A 96 -22. 498 -20. 696 —4.941 1. ,00 24. 59 CATOM 681 CG2 VAL A 96 -22. 498 -20. 696 —4.941 1., 00 24. 59 C
ATOM 682 C VAL A 96 -21. 853 - 24. 137 -6.550 1. ,00 23. 44 CATOM 682 C VAL A 96 -21. 853-24. 137 -6.550 1., 00 23. 44 C
ATOM 683 0 VAL A 96 -22. 443 - 24. 623 -7.512 1. ,00 23. 39 0ATOM 683 0 VAL A 96 -22.443-24.623 -7.512 1., 00 23.39 0
ATOM 684 N LEU A 97 -20. 611 -24. 482 -6.234 1. .00 23. 39 NATOM 684 N LEU A 97 -20. 611 -24. 482 -6.234 1. .00 23. 39 N
ATOM 685 CA LEU A 97 -19. 843 -25. 395 - 7.082 1. .00 25. 41 CATOM 685 CA LEU A 97 -19. 843 -25. 395-7.082 1. .00 25. 41 C
ATOM 686 CB LEU A 97 -18. 412 -25. 528 -6.559 1. ,00 23. 36 CATOM 686 CB LEU A 97 -18. 412 -25. 528 -6.559 1., 00 23. 36 C
ATOM 687 CG LEU A 97 - 17. 592 -24.233 -6.537 1. .00 23. 21 CATOM 687 CG LEU A 97-17. 592 -24.233 -6.537 1. .00 23. 21 C
ATOM 688 CD1 LEU A 97 - 16. 225 -24. 463 -5.912 1. ,00 22. 95 CATOM 688 CD1 LEU A 97-16. 225 -24. 463 -5.912 1., 00 22. 95 C
ATOM 689 CD2 LEU A 97 - 17. 449 - 23. 734 - 7.952 1. .00 22. 63 CATOM 689 CD2 LEU A 97-17. 449-23. 734-7.952 1. .00 22. 63 C
ATOM 690 C LEU A 97 -20.-516 -26. 770 -7.139 1. .00 27. 66 CATOM 690 C LEU A 97 -20.-516 -26. 770 -7.139 1. .00 27. 66 C
ATOM 691 0 LEU A 97 -20.412 - 27. 483 -8.135 1, .00 29. 03 0ATOM 691 0 LEU A 97 -20.412-27. 483 -8.135 1, .00 29. 03 0
ATOM 692 N GLU A 98 -21. 220 -27. 130 - 6.073 1. .00 27. 89 NATOM 692 N GLU A 98 -21. 220 -27. 130-6.073 1. .00 27. 89 N
ATOM 693 CA 6LU A 98 -22.034 -28. 341 - 6.079 1, .00 29. 35 CATOM 693 CA 6LU A 98 -22.034 -28.341-6.079 1, .00 29. 35 C
ATOM 694 CB GLU A 98 -22.861 -28. 418 -4.797 1, .00 34. 40 CATOM 694 CB GLU A 98 -22.861 -28.418 -4.797 1, .00 34. 40 C
ATOM 695 CG GLU A 98 -22.457 -29. 542 -3.867 1 .00 41. 69 C ATOM 696 CD GLU A 98 -23.656 -30.351 - 3.405 1.00 46.64 CATOM 695 CG GLU A 98 -22.457 -29. 542 -3.867 1 .00 41. 69 C ATOM 696 CD GLU A 98 -23.656 -30.351-3.405 1.00 46.64 C
ATOM 697 0E1 GLU A 98 -23.522 - 3.281 1. 00 49.50 0ATOM 697 0E1 GLU A 98 -23.522-3.281 1.00 49.50 0
ATOM 698 0E2 GLU A 98 - 24.729 -29.743 -3, 171 1. 00 46.92 0ATOM 698 0E2 GLU A 98-24.729 -29.743 -3, 171 1. 00 46.92 0
ATOM 699 C GLU A 98 -22.973 -28.412 -7.284 1. 00 28.74 CATOM 699 C GLU A 98 -22.973 -28.412 -7.284 1.00 28.74 C
ATOM 700 0 GLU A 98 -23.121 -29.463 -7.902 1. 00 27.75 0ATOM 700 0 GLU A 98 -23.121 -29.463 -7.902 1.00 27.75 0
ATOM 701 N ASN A 99 -23.610 - 27.292 -7.611 1. 00 26.91 NATOM 701 N ASN A 99 -23.610-27.292 -7.611 1. 00 26.91 N
ATOM 702 CA ASN A 99 -24.580 -27.257 -8.699 1. 00 25.01 CATOM 702 CA ASN A 99 -24.580 -27.257 -8.699 1.00 25.01 C
ATOM 703 CB ASN A 99 - 25.551 -26.085 -8.508 1. 00 25.50 CATOM 703 CB ASN A 99-25.551 -26.085 -8.508 1. 00 25.50 C
ATOM 704 C6 ASN A 99 -26.462 -26.270 -7.306 1. 00 22.99 CATOM 704 C6 ASN A 99 -26.462 -26.270 -7.306 1.00 22.99 C
ATOM 705 0D1 ASN A 99 - 27.571 -26.781 -7.433 1. 00 27.43 0ATOM 705 0D1 ASN A 99-27.571 -26.781 -7.433 1.00 27.43 0
ATOM 706 ND2 ASN A 99 - 25.997 - 25.857 -6.137 1. 00 19.92 NATOM 706 ND2 ASN A 99-25.997-25.857 -6.137 1. 00 19.92 N
ATOM 707 C ASN A 99 -23.873 -27.124 -10.044 1. 00 23.04 CATOM 707 C ASN A 99 -23.873 -27.124 -10.044 1. 00 23.04 C
ATOM 708 0 ASN A 99 -24.365 - 27.605 - 11.061 1. 00 20.80 0ATOM 708 0 ASN A 99 -24.365-27.605-11.061 1.00 20.80 0
ATOM 709 N VAL A 100 -22.720 -26.467 -10.032 1. 00 21.09 NATOM 709 N VAL A 100 -22.720 -26.467 -10.032 1.00 21.09 N
ATOM 710 CA VAL A 100 -21.924 -26.253 -11.239 1. 00 21.99 CATOM 710 CA VAL A 100 -21.924 -26.253 -11.239 1. 00 21.99 C
ATOM 711 CB VAL A 100 -22.107 -24.814 -11.772 1. 00 25.31 CATOM 711 CB VAL A 100 -22.107 -24.814 -11.772 1. 00 25.31 C
ATOM 712 CG1 VAL A 100 -24.602 -13.012 1. 00 21.75 CATOM 712 CG1 VAL A 100 -24.602 -13.012 1.00 21.75 C
ATOM 713 C62 VAL A 100 -23.591 -24.555 -12.087 1. .00 20.99 CATOM 713 C62 VAL A 100 -23.591 -24.555 -12.087 1. .00 20.99 C
ATOM 714 C VAL A 100 - 20.441 -26.472 - 10.919 1. 00 22.14 CATOM 714 C VAL A 100-20.441 -26.472-10.919 1. 00 22.14 C
ATOM 715 0 VAL A 100 -19.696 -25.523 -10.682 1. ,00 21.89 0ATOM 715 0 VAL A 100 -19.696 -25.523 -10.682 1., 00 21.89 0
ATOM 716 N PRO A 101 -20.004 -27.741 -10.881 1. .00 22.66 ATOM 716 N PRO A 101 -20.004 -27.741 -10.881 1. .00 22.66
ATOM 717 CD PRO A 101 -20.794 - 28.938 -11.213 1. ,00 22.42 C ATOM 717 CD PRO A 101 -20.794-28.938 -11.213 1., 00 22.42 C
ATOM 718 CA PRO A 101 -18.657 -28.088 -10.421 1. .00 22.65 CATOM 718 CA PRO A 101 -18.657 -28.088 -10.421 1. .00 22.65 C
ATOM 719 CB PRO A 101 -18.711 -29.604 -10.259 1, .00 22.57 CATOM 719 CB PRO A 101 -18.711 -29.604 -10.259 1, .00 22.57 C
ATOM 720 CG PRO A 101 -19.754 -30.039 -11.231 1. .00 23.60 CATOM 720 CG PRO A 101 -19.754 -30.039 -11.231 1. .00 23.60 C
ATOM 721 C PRO A 101 -17.529 -27.654 - 11.350 1, .00 22.29 CATOM 721 C PRO A 101 -17.529 -27.654-11.350 1, .00 22.29 C
ATOM 722 0 PRO A 101 -16.386 -27.566 -10.921 1 .00 21.90 0ATOM 722 0 PRO A 101 -16.386 -27.566 -10.921 1 .00 21.90 0
ATOM 723 N SER A 102 一 17.841 -27.386 -12.614 1. .00 22.18 NATOM 723 N SER A 102 17.841 -27.386 -12.614 1. .00 22.18 N
ATOM 724 CA SER A 102 -16.815 -26.953 -13.561 1 .00 25.44 CATOM 724 CA SER A 102 -16.815 -26.953 -13.561 1 .00 25.44 C
ATOM 725 CB SER A 102 -17.152 -27.422 -14.982 1 .00 27.00 CATOM 725 CB SER A 102 -17.152 -27.422 -14.982 1 .00 27.00 C
ATOM 726 OG SER A 102 -16.884 -28.810 -15.150 1 .00 30.78 0ATOM 726 OG SER A 102 -16.884 -28.810 -15.150 1 .00 30.78 0
ATOM 727 C SER A 102 -16.626 - 25.440 -13.566 1 .00 26.92 CATOM 727 C SER A 102 -16.626-25.440 -13.566 1 .00 26.92 C
ATOM 728 0 SER A 102 -15.837 -24.908 -14.354 1 .00 26.57 0ATOM 728 0 SER A 102 -15.837 -24.908 -14.354 1 .00 26.57 0
ATOM 729 N ALA A 103 -17.346 -24.745 -12.690 1 .00 24.58 NATOM 729 N ALA A 103 -17.346 -24.745 -12.690 1 .00 24.58 N
ATOM 730 CA ALA A 103 -17.334 - 23.292 -12.711 1 .00 23.29 CATOM 730 CA ALA A 103 -17.334-23.292 -12.711 1 .00 23.29 C
ATOM 731 CB ALA A 103 -18.436 -22.732 1 .00 24.38 C 5 ATOM 731 CB ALA A 103 -18.436 -22.732 1 .00 24.38 C Five
ATOM 732 C ALA A 103 —15.978 -22.724 -12.314 1. 00 23.22 CATOM 732 C ALA A 103 —15.978 -22.724 -12.314 1. 00 23.22 C
ATOM 733 0 ALA A 103 —15.234 -23.310 -11.525 1. 00 21.76 0ATOM 733 0 ALA A 103 -15.234 -23.310 -11.525 1. 00 21.76 0
ATOM 734 N ARG A 104 -15.679 -21.564 -12.881 1. 00 24.30 NATOM 734 N ARG A 104 -15.679 -21.564 -12.881 1. 00 24.30 N
ATOM 735 CA ARG A 104 -14.545 -20.743 -12.486 1. 00 24.44 CATOM 735 CA ARG A 104 -14.545 -20.743 -12.486 1. 00 24.44 C
ATOM 736 CB ARG A 104 - 14.432 -19.578 -13.462 1. 00 25.99 CATOM 736 CB ARG A 104-14.432 -19.578 -13.462 1. 00 25.99 C
ATOM 737 C6 ARG A 104 - 13.043 -19.219 -13.908 1. 00 32.17 CATOM 737 C6 ARG A 104-13.043 -19.219 -13.908 1. 00 32.17 C
ATOM 738 CD ARG A 104 -13.073 -18.826 -15.381 1. 00 33.97 CATOM 738 CD ARG A 104 -13.073 -18.826 -15.381 1. 00 33.97 C
ATOM 739 NE ARG A 104 - 12.354 -17.583 -15.640 1. 00 37.16 NATOM 739 NE ARG A 104-12.354 -17.583 -15.640 1.00 37.16 N
ATOM 740 CZ ARG A 104 -12.843 -16.373 -15.385 1. 00 39.33 . CATOM 740 CZ ARG A 104 -12.843 -16.373 -15.385 1. 00 39.33. C
ATOM 741 NH1 ARG A 104 一 14.056 -16.245 -14.859 1. 00 40.64 NATOM 741 NH1 ARG A 104 1 14.056 -16.245 -14.859 1.00 40.64 N
ATOM 742 NH2 ARG A 104 -12.126 -15.291 —15.669 1. 00 37.66 NATOM 742 NH2 ARG A 104 -12.126 -15.291 —15.669 1. 00 37.66 N
ATOM 743 C ARG A 104 -14.765 -20.203 -11.065 1. 00 23.56 CATOM 743 C ARG A 104 -14.765 -20.203 -11.065 1. 00 23.56 C
ATOM 744 0 ARG A 104 -15.879 -19.825 -10.698 1. 00 21.20 0ATOM 744 0 ARG A 104 -15.879 -19.825 -10.698 1. 00 21.20 0
ATOM 745 N ILE A 105 -13.703 -20.173 - 10.271 1. 00 22.73 NATOM 745 N ILE A 105 -13.703 -20.173-10.271 1. 00 22.73 N
ATOM 746 CA ILE A 105 -13.743 -19.499 -8.979 1. 00 21.06 CATOM 746 CA ILE A 105 -13.743 -19.499 -8.979 1. 00 21.06 C
ATOM 747 CB ILE A 105 —13.131 —20.350 —7.863 1. 00 21.28 CATOM 747 CB ILE A 105 —13.131 —20.350 —7.863 1. 00 21.28 C
ATOM 748 CG2 ILE A 105 -13.158 -19.565 -6.563 1. ,00 18.47 CATOM 748 CG2 ILE A 105 -13.158 -19.565 -6.563 1., 00 18.47 C
ATOM 749 CG1 ILE A 105 - 13.862 -21.697 -7.761 1. 00 16.81 CATOM 749 CG1 ILE A 105-13.862 -21.697 -7.761 1. 00 16.81 C
ATOM 750 CD1 ILE A 105 -13.062 —22.782 -7.076 1. ,00 13.14 CATOM 750 CD1 ILE A 105 -13.062 -22.782 -7.076 1., 00 13.14 C
ATOM 751 C ILE A 105 一 12.919 —18.239 -9.080 1. ,00 21.55 CATOM 751 C ILE A 105 1 12.919 —18.239 -9.080 1., 00 21.55 C
ATOM 752 0 ILE A 105 -11.830 -18.245 -9.648 1. , 00 22.66 0ATOM 752 0 ILE A 105 -11.830 -18.245 -9.648 1., 00 22.66 0
ATOM 753 N SER A 106 -13.429 -17.160 -8.511 1. .00 21.39 NATOM 753 N SER A 106 -13.429 -17.160 -8.511 1. .00 21.39 N
ATOM 754 CA SER A 106 一 12.754 -15.880 -8.594 1. .00 21.26 CATOM 754 CA SER A 106 1 12.754 -15.880 -8.594 1. .00 21.26 C
ATOM 755 CB SER A 106 -13.328 -15.092 -9.779 1. .00 20.68 CATOM 755 CB SER A 106 -13.328 -15.092 -9.779 1. .00 20.68 C
ATOM 756 OG SER A 106 -12.490 -14.025 -10. '166 1. .00 26.88 0ATOM 756 OG SER A 106 -12.490 -14.025 -10. '166 1. .00 26.88 0
ATOM 757 C SER A 106 -13.008 -15.152 -7.282 1, .00 21.39 CATOM 757 C SER A 106 -13.008 -15.152 -7.282 1, .00 21.39 C
ATOM 758 0 SER A 106 -14.001 -14.440 一 7· 151 1, .00 20.40 0ATOM 758 0 SER A 106 -14.001 -14.440 One 7 ・ 151 1, .00 20.40 0
ATOM 759 N VAL A 107 —12.122 -15.342 —6.304 1 .00 22.08 NATOM 759 N VAL A 107 —12.122 -15.342 —6.304 1 .00 22.08 N
ATOM 760 CA VAL A 107 -12.366 -14.809 -4.969 1, .00 22.43 CATOM 760 CA VAL A 107 -12.366 -14.809 -4.969 1, .00 22.43 C
ATOM 761 CB VAL A 107 -11.568 -15.555 -3.877 1 .00 22.09 CATOM 761 CB VAL A 107 -11.568 -15.555 -3.877 1 .00 22.09 C
ATOM 762 CG1 VAL A 107 -11.909 -17.031 —3.884 1 ■ 00 21.85 CATOM 762 CG1 VAL A 107 -11.909 -17.031 —3.884 1 ■ 00 21.85 C
ATOM 763 CG2 VAL A 107 - 10.096 -15.356 -4.087 1 .00 25.10 CATOM 763 CG2 VAL A 107-10.096 -15.356 -4.087 1 .00 25.10 C
ATOM 764 C VAL A 107 -11.990 -13.348 - 4.902 1 .00 23.03 CATOM 764 C VAL A 107 -11.990 -13.348-4.902 1 .00 23.03 C
ATOM 765 0 VAL A 107 -10.962 -12.944 -5.429 1 • 00 25.70 0ATOM 765 0 VAL A 107 -10.962 -12.944 -5.429 1 • 00 25.70 0
ATOM 766 N VAL A 108 -12.825 -12.548 -4.251 1 .00 25.32 NATOM 766 N VAL A 108 -12.825 -12.548 -4.251 1 .00 25.32 N
ATOM 767 CA VAL A 108 -12.492 -11.147 —4.058 1 .00 26.73 C ATOM 768 CB VAL A 108 -13.535 -10.229 -4.715 1.00 26.74 CATOM 767 CA VAL A 108 -12.492 -11.147 —4.058 1 .00 26.73 C ATOM 768 CB VAL A 108 -13.535 -10.229 -4.715 1.00 26.74 C
ATOM 769 CG1 VAL A 108 -13.976 - 10.827 -6.038 1. 00 24.02 CATOM 769 CG1 VAL A 108 -13.976-10.827 -6.038 1. 00 24.02 C
ATOM 770 CG2 VAL A 108 - 14.702 -10.010 -3.792 1. 00 28.96 CATOM 770 CG2 VAL A 108-14.702 -10.010 -3.792 1. 00 28.96 C
ATOM 771 C VAL A 108 -12.378 -10.811 -2.578 1. 00 27.26 CATOM 771 C VAL A 108 -12.378 -10.811 -2.578 1.00 27.26 C
ATOM 772 0 VAL A 108 - 13.117 -11.338 - 1. 746 1. 00 23.50 0ATOM 772 0 VAL A 108-13.117 -11.338-1. 746 1. 00 23.50 0
ATOM 773 N 6LY A 109 -11.420 -9.943 - 2. 263 1. 00 30.79 NATOM 773 N 6LY A 109 -11.420 -9.943-2. 263 1. 00 30.79 N
ATOM 774 CA 6LY A 109 - 11.265 -9.443 -0. 910 1. 00 32.45 CATOM 774 CA 6LY A 109-11.265 -9.443 -0. 910 1. 00 32.45 C
ATOM 775 C GLY A 109 - 11.603 -7.966 - 0. 812 1. 00 34.39 CATOM 775 C GLY A 109-11.603 -7.966-0. 812 1. 00 34.39 C
ATOM 776 0 GLY A 109 -11.827 - 7.299 - 1. 822 1. 00 32.55 0ATOM 776 0 GLY A 109 -11.827-7.299-1. 822 1. 00 32.55 0
ATOM 777 N MET A 110 -11.635 - 7.451 0. 411 1. 00 38.14 NATOM 777 N MET A 110 -11.635-7.451 0. 411 1. 00 38.14 N
ATOM 778 CA MET A 110 -11.870 -6.031 0. 635 \. 00 44.14 CATOM 778 CA MET A 110 -11.870 -6.031 0. 635 \. 00 44.14 C
ATOM 779 CB MET A 110 -13.157 -5.856 1. 445 1. 00 44.30 CATOM 779 CB MET A 110 -13.157 -5.856 1.445 1. 00 44.30 C
ATOM 780 CG MET A 110 -14.209 -4.993 0. 779 1. 00 46.19 CATOM 780 CG MET A 110 -14.209 -4.993 0. 779 1. 00 46.19 C
ATOM 781 SD MET A 110 -14.944 - 5.746 - 0. 681 1. 00 45.66 SATOM 781 SD MET A 110 -14.944-5.746-0. 681 1. 00 45.66 S
ATOM 782 CE MET A 110 -15.370 -4.290 -1. 597 1. 00 46.41 CATOM 782 CE MET A 110 -15.370 -4.290 -1. 597 1. 00 46.41 C
ATOM 783 C MET A 110 -10.692 -5.407 1. 392 1. 00 47.36 CATOM 783 C MET A 110 -10.692 -5.407 1. 392 1. 00 47.36 C
ATOM 784 0 MET A 110 -10.521 - 5.661 2. 585 1. 00 48.96 0ATOM 784 0 MET A 110 -10.521-5.661 2. 585 1. 00 48.96 0
ATOM 785 N TYR A 111 -9.879 - 4.596 0. 713 1. 00 50.96 NATOM 785 N TYR A 111 -9.879-4.596 0. 713 1. 00 50.96 N
ATOM 786 CA TYR A 111 - 8.800 -3.879 1. 398 1. 00 52.69 CATOM 786 CA TYR A 111-8.800 -3.879 1. 398 1. 00 52.69 C
ATOM 787 CB TYR A 111 -7.988 -3.014 0. 424 1. ,00 52.98 CATOM 787 CB TYR A 111 -7.988 -3.014 0. 424 1., 00 52.98 C
ATOM 788 CG TYR A 111 -7.081 -3.763 -0. 534 1. 00 54.59 CATOM 788 CG TYR A 111 -7.081 -3.763 -0. 534 1. 00 54.59 C
ATOM 789 CD1 TYR A 111 -6.984 -3.375 - 1. 868 1. ,00 54.50 CATOM 789 CD1 TYR A 111 -6.984 -3.375-1. 868 1., 00 54.50 C
ATOM 790 CE1 TYR A 111 - 6.161 -4.055 -1.762 1. ,00 53.90 CATOM 790 CE1 TYR A 111-6.161 -4.055 -1.762 1., 00 53.90 C
ATOM 791 CD2 TYR A 111 -6.323 -4.856 - 0. 114 1. .00 54.62 CATOM 791 CD2 TYR A 111 -6.323 -4.856-0. 114 1. .00 54.62 C
ATOM 792 CE2 TYR A 111 -5.495 -5.544 — 1. 004 1. ,00 53.55 CATOM 792 CE2 TYR A 111 -5.495 -5.544 — 1. 004 1., 00 53.55 C
ATOM 793 CZ TYR A 111 -5.422 - 5.137 - 2. 327 1. .00 53.11 CATOM 793 CZ TYR A 111 -5.422-5.137-2. 327 1. .00 53.11 C
ATOM 794 OH TYR A 111 -4.628 -5.814 -3. 226 1, .00 50.54 0ATOM 794 OH TYR A 111 -4.628 -5.814 -3. 226 1, .00 50.54 0
ATOM 795 C TYR A 111 -9.414 -2.968 2. 453 1. .00 54.64 CATOM 795 C TYR A 111 -9.414 -2.968 2. 453 1. .00 54.64 C
ATOM 796 0 TYR A 111 - 10.326 -2.197 2. 161 1, .00 53.70 0ATOM 796 0 TYR A 111-10.326 -2.197 2. 161 1, .00 53.70 0
ATOM 797 N ARG A 112 -8.917 -3.060 3. 680 1, .00 58.71 NATOM 797 N ARG A 112 -8.917 -3.060 3.680 1, .00 58.71 N
ATOM 798 CA ARG A 112 - 9.368 -2.177 4. 750 1 .00 63.07 CATOM 798 CA ARG A 112-9.368 -2.177 4. 750 1 .00 63.07 C
ATOM 799 CB ARG A 112 -10.214 -2.960 5. 759 1, .00 63.11 CATOM 799 CB ARG A 112 -10.214 -2.960 5.759 1, .00 63.11 C
ATOM 800 CG ARG A 112 -11.347 -3.745 5. 118 1 .00 64.16 CATOM 800 CG ARG A 112 -11.347 -3.745 5. 118 1 .00 64.16 C
ATOM 801 CD AR6 A 112 -12.352 -4.245 6. , 144 1 ■ 00 64.56 CATOM 801 CD AR6 A 112 -12.352 -4.245 6., 144 1 ■ 00 64.56 C
ATOM 802 NE ARG A 112 -13.709 -3.822 5. 808 1 • 00 64.87 NATOM 802 NE ARG A 112 -13.709 -3.822 5. 808 1 • 00 64.87 N
ATOM 803 CZ ARG A 112 -14.516 -4.476 4. ,979 1 .00 65.24 C IS ATOM 803 CZ ARG A 112 -14.516 -4.476 4., 979 1 .00 65.24 C IS
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SS.T.0/.00Zdf/X3d ocr.so/6ooz; OAV ATOM 840 0 THR A 116 -10.446 6.190 1.345 1.00 75.09 0SS.T.0 / .00Zdf / X3d ocr.so/6ooz; OAV ATOM 840 0 THR A 116 -10.446 6.190 1.345 1.00 75.09 0
ATOM 841 N LEU A 117 -10.365 5.607 3.519 1. 00 75.16 NATOM 841 N LEU A 117 -10.365 5.607 3.519 1. 00 75.16 N
ATOM 842 CA LEU A 117 -11.724 6.055 3.815 1. 00 75.40 CATOM 842 CA LEU A 117 -11.724 6.055 3.815 1.00 75.40 C
ATOM 843 CB LEU A 117 -11.830 7.575 3.630 1. 00 76.02 CATOM 843 CB LEU A 117 -11.830 7.575 3.630 1.00 76.02 C
ATOM 844 CG LEU A 117 -11.050 8.433 4.634 1. 00 76.55 CATOM 844 CG LEU A 117 -11.050 8.433 4.634 1. 00 76.55 C
ATOM 845 CD1 LEU A 117 -10.917 9.856 4.115 1. 00 75.98 CATOM 845 CD1 LEU A 117 -10.917 9.856 4.115 1. 00 75.98 C
ATOM 846 CD2 LEU A 117 -11.757 8.411 5.983 1. 00 76.50 CATOM 846 CD2 LEU A 117 -11.757 8.411 5.983 1.00 76.50 C
ATOM 847 C LEU A 117 -12.750 5.347 2.933 1. 00 74.91 CATOM 847 C LEU A 117 -12.750 5.347 2.933 1. 00 74.91 C
ATOM 848 0 LEU A 117 -13， 721 5.956 2.473 1. 00 74.76 0ATOM 848 0 LEU A 117 -13, 721 5.956 2.473 1. 00 74.76 0
ATOM 849 N GLU A 118 -12.528 4.056 2.706 1. 00 73.70 NATOM 849 N GLU A 118 -12.528 4.056 2.706 1. 00 73.70 N
ATOM 850 CA 6LU A 118 -13.390 3.271 1.832 1. 00 CATOM 850 CA 6LU A 118 -13.390 3.271 1.832 1. 00 C
ATOM 851 . CB GLU A 118 -13.415 3.886 0.432 1. 00 73.13 CATOM 851 .CB GLU A 118 -13.415 3.886 0.432 1. 00 73.13 C
ATOM 852 CG GLU A 118 -14.692 3.616 - 0.331 1. 00 75.16 CATOM 852 CG GLU A 118 -14.692 3.616-0.331 1. 00 75.16 C
ATOM 853 CD GLU A 118 -15.901 4.201 0.368 1. 00 77.69 CATOM 853 CD GLU A 118 -15.901 4.201 0.368 1. 00 77.69 C
ATOM 854 0E1 GLU A 118 -16.302 5.333 0.018 1. 00 78.54 0ATOM 854 0E1 GLU A 118 -16.302 5.333 0.018 1.00 78.54 0
ATOM 855 0E2 GLU A 118 -16.448 3.530 1.273 1. 00 78.92 0ATOM 855 0E2 GLU A 118 -16.448 3.530 1.273 1. 00 78.92 0
ATOM 856 C GLU A 118 -12.882 1.836 1.743 1. ,00 69.72 CATOM 856 C GLU A 118 -12.882 1.836 1.743 1., 00 69.72 C
Λ 1  Λ 1
ATOM 857 0 GLU A 118 -11.675 1.596 1.713 1. ,00 70.33 0 ATOM 857 0 GLU A 118 -11.675 1.596 1.713 1., 00 70.33 0
ATOM 858 N PRO A 119 -13.802 0.860 1.721 1. 00 66.91 NATOM 858 N PRO A 119 -13.802 0.860 1.721 1. 00 66.91 N
ATOM 859 CD PRO A 119 - 15.142 0.958 2.321 1. .00 66.61 CATOM 859 CD PRO A 119-15.142 0.958 2.321 1. .00 66.61 C
ATOM 860 CA PRO A 119 -13.473 -0.521 1.346 1, ,00 63.70 CATOM 860 CA PRO A 119 -13.473 -0.521 1.346 1,, 00 63.70 C
ATOM 861 CB PRO A 119 -14.700 -1.319 1.787 1. .00 64.69 CATOM 861 CB PRO A 119 -14.700 -1.319 1.787 1. .00 64.69 C
ATOM 862 CG PRO A 119 -15.390 -0.443 2.787 1. .00 66.01 CATOM 862 CG PRO A 119 -15.390 -0.443 2.787 1. .00 66.01 C
ATOM 863 C PRO A 119 -13.237 -0.649 -0.158 1. .00 60.78 CATOM 863 C PRO A 119 -13.237 -0.649 -0.158 1. .00 60.78 C
ATOM 864 0 PRO A 119 -14.175 - 0.523 -0.951 1. .00 59.56 0ATOM 864 0 PRO A 119 -14.175-0.523 -0.951 1. .00 59.56 0
ATOM 865 N VAL A 120 -11.991 - 0.898 -0.550 1. .00 56.55 NATOM 865 N VAL A 120 -11.991-0.898 -0.550 1. .00 56.55 N
ATOM 866 CA VAL A 120 -11.690 -1.152 -1.954 1, .00 53.62 CATOM 866 CA VAL A 120 -11.690 -1.152 -1.954 1, .00 53.62 C
ATOM 867 CB VAL A 120 - 10.404 -0.402 -2.415 1, .00 53.71 CATOM 867 CB VAL A 120-10.404 -0.402 -2.415 1, .00 53.71 C
ATOM 868 CG1 VAL A 120 -9.235 -0.745 - 1.512 1, .00 CATOM 868 CG1 VAL A 120 -9.235 -0.745-1.512 1, .00 C
ATOM 869 CG2 VAL A 120 - 10.089 - 0.757 - 3.863 1, .00 51.96 CATOM 869 CG2 VAL A 120-10.089-0.757-3.863 1, .00 51.96 C
ATOM 870 C VAL A 120 -11.542 -2.647 - 2.221 1, .00 51.59 CATOM 870 C VAL A 120 -11.542 -2.647-2.221 1, .00 51.59 C
ATOM 871 0 VAL A 120 -10.777 -3.346 -1.550 1 .00 52.50 0ATOM 871 0 VAL A 120 -10.777 -3.346 -1.550 1 .00 52.50 0
ATOM 872 N PRO A 121 -12.301 -3.159 - 3.198 1 • 00 47.88 NATOM 872 N PRO A 121 -12.301 -3.159-3.198 1 • 00 47.88 N
ATOM 873 CD PRO A 121 -13.223 -2.371 -4.036 1 .00 48.08 CATOM 873 CD PRO A 121 -13.223 -2.371 -4.036 1 .00 48.08 C
ATOM 874 CA PRO A 121 -12.320 -4.580 -3.552 1 .00 45.96 CATOM 874 CA PRO A 121 -12.320 -4.580 -3.552 1 .00 45.96 C
ATOM 875 CB PRO A 121 一 13.636 一 4.736 -4.302 1 ■ 00 46.74 C P2007/071755 ATOM 875 CB PRO A 121 1 13.636 1 4.736 -4.302 1 ■ 00 46.74 C P2007 / 071755
ATOM 876 CG PRO A 121 -13.809 -3.398 -4.983 1. 00 47.30 CATOM 876 CG PRO A 121 -13.809 -3.398 -4.983 1.00 47.30 C
ATOM 877 C PRO A 121 -11.128 -4.932 -4.429 1. 00 43.37 CATOM 877 C PRO A 121 -11.128 -4.932 -4.429 1. 00 43.37 C
ATOM 878 0 PRO A 121 -10.574 -4.071 -5.116 1. 00 43.17 0ATOM 878 0 PRO A 121 -10.574 -4.071 -5.116 1.00 43.17 0
ATOM 879 N TYR A 122 -10.740 -6.200 -4.415 1. 00 40.67 NATOM 879 N TYR A 122 -10.740 -6.200 -4.415 1. 00 40.67 N
ATOM 880 CA TYR A 122 -9.673 -6.666 -5.293 1. 00 37.30 CATOM 880 CA TYR A 122 -9.673 -6.666 -5.293 1.00 37.30 C
ATOM 881 CB TYR A 122 -8.319 -6.438 -4.627 1. 00 35.51 CATOM 881 CB TYR A 122 -8.319 -6.438 -4.627 1. 00 35.51 C
ATOM 882 CG TYR A 122 - 8.169 -7.167 -3.317 1. 00 33.50 GATOM 882 CG TYR A 122-8.169 -7.167 -3.317 1.00 33.50 G
ATOM 883 CD1 TYR A 122 - 8.602 -6.596 -2.129 1. 00 32.13 CATOM 883 CD1 TYR A 122-8.602 -6.596 -2.129 1. 00 32.13 C
ATOM 884 CE1 TYR A 122 - 8.458 -7.263 - 0.927 1. 00 36.39 CATOM 884 CE1 TYR A 122-8.458 -7.263-0.927 1. 00 36.39 C
ATOM 885 CD2 TYR A 122 -7.590 -8.425 - 3.270 1. 00 33.19 CATOM 885 CD2 TYR A 122 -7.590 -8.425-3.270 1.00 33.19 C
ATOM 886 CE2 TYR A 122 -7.441 - 9.098 -2.078 1. 00 34.78 CATOM 886 CE2 TYR A 122 -7.441-9.098 -2.078 1.00 34.78 C
ATOM 887 ■CZ TYR A 122 -7.875 -8.515 - 0.909 1. 00 36.65 CATOM 887 CZ TYR A 122 -7.875 -8.515-0.909 1.00 36.65 C
ATOM 888 OH TYR A 122 -7.723 - 9.189 0.278 1. 00 38.80 0ATOM 888 OH TYR A 122 -7.723-9.189 0.278 1.00 38.80 0
ATOM 889 C TYR A 122 - 9.830 - 8.143 -5.626 1. 00 35.24 CATOM 889 C TYR A 122-9.830-8.143 -5.626 1. 00 35.24 C
ATOM 890 0 TYR A 122 -10.258 -8.935 - 4.790 1. 00 33.59 0ATOM 890 0 TYR A 122 -10.258 -8.935-4.790 1.00 33.59 0
ATOM 891 N PHE A 123 -9.492 -8.504 -6.857 1. 00 35.79 NATOM 891 N PHE A 123 -9.492 -8.504 -6.857 1. 00 35.79 N
ATOM 892 CA PHE A 123 - 9.336 -9.906 -7.217 1. 00 34.69 CATOM 892 CA PHE A 123-9.336 -9.906 -7.217 1.00 34.69 C
ATOM 893 CB PHE A 123 - 9.209 -10.079 - 8.726 1. 00 34.83 CATOM 893 CB PHE A 123-9.209 -10.079-8.726 1. 00 34.83 C
ATOM 894 CG PHE A 123 -10.416 -9.651 - 9.496 1. 00.37.37 CATOM 894 CG PHE A 123 -10.416 -9.651-9.496 1. 00.37.37 C
ATOM 895 CD1 PHE A 123 -10.383 -8.504 -10.272 1. 00 38.83 CATOM 895 CD1 PHE A 123 -10.383 -8.504 -10.272 1. 00 38.83 C
ATOM 896 CD2 PHE A 123 -11.572 -10.410 -9.473 1. , 00 39.84 CATOM 896 CD2 PHE A 123 -11.572 -10.410 -9.473 1., 00 39.84 C
ATOM 897 CE1 PHE A 123 -11.479 - 8.123 -11.014 1. ,00 41.87 CATOM 897 CE1 PHE A 123 -11.479-8.123 -11.014 1., 00 41.87 C
ATOM 898 CE2 PHE A 123 - 12.678 -10.039 -10.211 1. .00 41.50 CATOM 898 CE2 PHE A 123-12.678 -10.039 -10.211 1. .00 41.50 C
ATOM 899 CZ PHE A 123 -12.634 -8.895 -10.984 1. .00 43.37 CATOM 899 CZ PHE A 123 -12.634 -8.895 -10.984 1. .00 43.37 C
ATOM 900 C PHE A 123 -8.060 -10.406 - 6· 577 1. .00 33.46 CATOM 900 C PHE A 123 -8.060 -10.406-6 577 1. .00 33.46 C
ATOM 901 0 PHE A 123 -7.053 - 9.715 -6.579 1. .00 32.03 0ATOM 901 0 PHE A 123 -7.053-9.715 -6.579 1. .00 32.03 0
ATOM 902 N GLN A 124 - 8.107 -11.614 - 6.037 1. .00 35.07 NATOM 902 N GLN A 124-8.107 -11.614-6.037 1. .00 35.07 N
ATOM 903 CA GLN A 124 - 6.903 - 12.301 -5.594 1. .00 36.96 CATOM 903 CA GLN A 124-6.903-12.301 -5.594 1. .00 36.96 C
ATOM 904 CB GLN A 124 - 7.286 -13.635 -4.951 1, ■ 00 36.05 CATOM 904 CB GLN A 124-7.286 -13.635 -4.951 1, ■ 00 36.05 C
ATOM 905 C6 GLN A 124 -6.144 -14.356 - 4.290 1, .00 40.37 CATOM 905 C6 GLN A 124 -6.144 -14.356-4.290 1, .00 40.37 C
ATOM 906 CD GLN A 124 -5.621 -13.623 -3.073 1, .00 43.09 CATOM 906 CD GLN A 124 -5.621 -13.623 -3.073 1, .00 43.09 C
ATOM 907 0E1 GLN A 124 -4.417 -13.625 - 2.808 1 • 00 42.66 0ATOM 907 0E1 GLN A 124 -4.417 -13.625-2.808 1 • 00 42.66 0
ATOM 908 NE2 GLN A 124 -6.526 -12.992 -2.320 1 .00 44.02 NATOM 908 NE2 GLN A 124 -6.526 -12.992 -2.320 1 .00 44.02 N
ATOM 909 C GLN A 124 - 5.986 -12.519 -6.807 1 • 00 37.15 CATOM 909 C GLN A 124-5.986 -12.519 -6.807 1 • 00 37.15 C
ATOM 910 0 GLN A 124 -4.767 -12.404 -6.707 1 • 00 38.26 0ATOM 910 0 GLN A 124 -4.767 -12.404 -6.707 1 • 00 38.26 0
ATOM 911 N LYS A 125 -6.588 -12.822 -7.952 1 • 00 37.03 N ATOM 912 CA LYS A 125 -5.884 -12.812 -9.231 1.00 38.17 CATOM 911 N LYS A 125 -6.588 -12.822 -7.952 1 • 00 37.03 N ATOM 912 CA LYS A 125 -5.884 -12.812 -9.231 1.00 38.17 C
ATOM 913 CB LYS A 125 - 5.471 -14.228 -9.626 1. 00 38.31 CATOM 913 CB LYS A 125-5.471 -14.228 -9.626 1. 00 38.31 C
ATOM 914 CG LYS A 125 -5.077 -14.358 - 11.094 1. 00 42.12 CATOM 914 CG LYS A 125 -5.077 -14.358-11.094 1. 00 42.12 C
ATOM 915 CD LYS A 125 -4.151 -15.549 -11.353 1. 00 42.23 CATOM 915 CD LYS A 125 -4.151 -15.549 -11.353 1. 00 42.23 C
ATOM 916 CE LYS A 125 -3.684 -15.576一 12.810 1. 00 41.52 CATOM 916 CE LYS A 125 -3.684 -15.576 one 12.810 1.00 41.52 C
ATOM 917 NZ LYS A 125 - 2.488 -16.434 -13.010 1. 00 40.00 NATOM 917 NZ LYS A 125-2.488 -16.434 -13.010 1.00 40.00 N
ATOM 918 C LYS A 125 一 6.791 -12.224 -10.311 1. 00 38.38 CATOM 918 C LYS A 125 1 6.791 -12.224 -10.311 1. 00 38.38 C
ATOM 919 0 LYS A 125 -7.963 - 12.573 -10.399 1. 00 39.34 0ATOM 919 0 LYS A 125 -7.963-12.573 -10.399 1.00 39.34 0
ATOM 920 N LEU A 126 - 6.252 -11.336 1. 00 39.90 NATOM 920 N LEU A 126-6.252 -11.336 1. 00 39.90 N
ATOM 921 CA LEU A 126 -7.074 -10.632 -12.120 1. 00 41.42 CATOM 921 CA LEU A 126 -7.074 -10.632 -12.120 1.00 41.42 C
ATOM 922 CB LEU A 126 -6.461 - 9.261 -12.424 1. 00 43.86 CATOM 922 CB LEU A 126 -6.461-9.261 -12.424 1.00 43.86 C
ATOM 923 CG LEU A 126 -7.439 -8.082 -12.506 1. 00 47.99 CATOM 923 CG LEU A 126 -7.439 -8.082 -12.506 1.00 47.99 C
ATOM 924 CD1 LEU A 126 - 6.659 -6.783 -12.673 1. 00 50.33 CATOM 924 CD1 LEU A 126-6.659 -6.783 -12.673 1. 00 50.33 C
ATOM 925 CD2 LEU A 126 -8.402 - 8.275 -13.674 1. 00 48.52 CATOM 925 CD2 LEU A 126 -8.402-8.275 -13.674 1. 00 48.52 C
ATOM 926 C LEU A 126 - 7.238 -11.437 -13.410 1. 00 39.21 CATOM 926 C LEU A 126-7.238 -11.437 -13.410 1. 00 39.21 C
ATOM 927 0 LEU A 126 -6.267 -11.945 -13.956 1. 00 39.84 0ATOM 927 0 LEU A 126 -6.267 -11.945 -13.956 1.00 39.84 0
ATOM 928 N VAL A 127 - 8.478 -11.555 -13.880 1. .00 39.55 NATOM 928 N VAL A 127-8.478 -11.555 -13.880 1. .00 39.55 N
ATOM 929 CA VAL A 127 -8.799 -12.313 -15.089 1. ,00 39.60 CATOM 929 CA VAL A 127 -8.799 -12.313 -15.089 1., 00 39.60 C
ATOM 930 CB VAL A 127 - 9.405 -13.691 - 14.745 1. 00 40.78 CATOM 930 CB VAL A 127-9.405 -13.691-14.745 1. 00 40.78 C
ATOM 931 CG1 VAL A 127 -8.374 -14.556 -14.026 1. ,00 40.73 cATOM 931 CG1 VAL A 127 -8.374 -14.556 -14.026 1., 00 40.73 c
ATOM 932 C62 VAL A 127 -10.644 - 13.509 -13.873 1. ,00 41.12 cATOM 932 C62 VAL A 127 -10.644-13.509 -13.873 1., 00 41.12 c
ATOM 933 C VAL A 127 9· 811 -11.560 -15.946 1. .00 40.47 cATOM 933 C VAL A 127 9 811 -11.560 -15.946 1. .00 40.47 c
ATOM 934 0 VAL A 127 -10.423 -10.600 -15.485 1. ,00 41.43 0ATOM 934 0 VAL A 127 -10.423 -10.600 -15.485 1., 00 41.43 0
ATOM 935 N SER A 128 -9.990 -11.998 -17.189 1, .00 NATOM 935 N SER A 128 -9.990 -11.998 -17.189 1, .00 N
ATOM 936 CA SER A 128 -11.006 -11.416 -18.071 1. .00 42.45 cATOM 936 CA SER A 128 -11.006 -11.416 -18.071 1. .00 42.45 c
ATOM 937 CB SER A 128 -10.589 -11.532 -19.540 1, .00 42.66 cATOM 937 CB SER A 128 -10.589 -11.532 -19.540 1, .00 42.66 c
ATOM 938 OG SER A 128 - 9.461 -10.721 -19.811 1, .00 46.11 0ATOM 938 OG SER A 128-9.461 -10.721 -19.811 1, .00 46.11 0
ATOM 939 C SER A 128 - 12.345 -12.108 -17.892 1 .00 42.48 cATOM 939 C SER A 128-12.345 -12.108 -17.892 1 .00 42.48 c
ATOM 940 0 SER A 128 - 12.396 - 13.326 -17.694 1, .00 40.11 0ATOM 940 0 SER A 128-12.396-13.326 -17.694 1, .00 40.11 0
ATOM 941 N ASN A 129 -13.424 -11.329 -17.974 1 .00 42.44 NATOM 941 N ASN A 129 -13.424 -11.329 -17.974 1 .00 42.44 N
ATOM 942 CA ASN A 129 -14.776 -11.863 -17.817 1 .00 42.29 CATOM 942 CA ASN A 129 -14.776 -11.863 -17.817 1 .00 42.29 C
ATOM 943 CB ASN A 129 -15.523 -11.088 -16.724 1 .00 42.50 CATOM 943 CB ASN A 129 -15.523 -11.088 -16.724 1 .00 42.50 C
ATOM 944 CG ASN A 129 -15.010 -11.406 -15.326 1 ■ 00 43.00 CATOM 944 CG ASN A 129 -15.010 -11.406 -15.326 1 ∎ 00 43.00 C
ATOM 945 0D1 ASN A 129 -14.229 - 12.337 - 15.138 1 .00 42.05 0ATOM 945 0D1 ASN A 129 -14.229-12.337-15.138 1 .00 42.05 0
ATOM 946 ND2 ASN A 129 -15.451 -10.633 -14.339 1 • 00 42.75 NATOM 946 ND2 ASN A 129 -15.451 -10.633 -14.339 1 • 00 42.75 N
ATOM 947 C ASN A 129 -15.593一 11.853 -19.116 1 .00 42.51 C ATOM 948 0 ASN A 129 -16.815 -12.010 -19.092 1.00 41.42 0ATOM 947 C ASN A 129 -15.593 1 11.853 -19.116 1 .00 42.51 C ATOM 948 0 ASN A 129 -16.815 -12.010 -19.092 1.00 41.42 0
ATOM 949 N ILE A 130 -14.910 -11.688 - 20.247 1. 00 42.65 ΝATOM 949 N ILE A 130 -14.910 -11.688-20.247 1. 00 42.65 Ν
ATOM 950 CA lLE A 130 -15.562 -21.552 1. 00 40.65 CATOM 950 CA lLE A 130 -15.562 -21.552 1. 00 40.65 C
ATOM 951 CB ILE A 130 - 14.535 -11.357 -22.671 1. 00 40.75 CATOM 951 CB ILE A 130-14.535 -11.357 -22.671 1. 00 40.75 C
ATOM 952 CG2 ILE A 130 -15.169 -11.561 -24.031 1. 00 38.99 CATOM 952 CG2 ILE A 130 -15.169 -11.561 -24.031 1.00 38.99 C
ATOM 953 CGI ILE A 130 -13.986 -9.936 -22.523 1. 00 40.71 CATOM 953 CGI ILE A 130 -13.986 -9.936 -22.523 1. 00 40.71 C
ATOM 954 CD1 ILE A 130 -15.057 -8.857 - 22.556 1. 00 40.09 GATOM 954 CD1 ILE A 130 -15.057 -8.857-22.556 1. 00 40.09 G
ATOM 955 C ILE A 130 -16.316 -12.914 - 21.894 1. 00 41.75 CATOM 955 C ILE A 130 -16.316 -12.914-21.894 1. 00 41.75 C
ATOM 956 0 ILE A 130 -17, 520 -12.876 -22.148 1. 00 42.93 0ATOM 956 0 ILE A 130 -17, 520 -12.876 -22.148 1. 00 42.93 0
ATOM 957 N ASP A 131 -15.614 - 14.043 -21.891 1. 00 40.97 ΝATOM 957 N ASP A 131 -15.614-14.043 -21.891 1.00 40.97 Ν
ATOM 958 CA ASP A 131 -16.212 -15.316 -22.283 1. 00 42.37 C ATOM 958 CA ASP A 131 -16.212 -15.316 -22.283 1. 00 42.37 C
1  1
ATOM 959 ■CB ASP A 131 -15.114 -16.379 -22.434 1. 00 44.72 C ATOM 959 CB ASP A 131 -15.114 -16.379 -22.434 1. 00 44.72 C
ATOM 960 CG ASP A 131 -15.599 - 17.636 -23.153 1. 00 47.49 C ATOM 960 CG ASP A 131 -15.599-17.636 -23.153 1. 00 47.49 C
1  1
ATOM 961 0D1 ASP A 131 -16.452 -17.517 - 24.062 1. 00 47.28 0 ATOM 961 0D1 ASP A 131 -16.452 -17.517-24.062 1.00 47.28 0
ATOM 962 0D2 ASP A 131 -15.126 -18.743 -22.810 1. 00 48.76 0ATOM 962 0D2 ASP A 131 -15.126 -18.743 -22.810 1. 00 48.76 0
ATOM 963 C ASP A 131 -17.274 -15.790 -21■ 275 1. 00 42.14 CATOM 963 C ASP A 131 -17.274 -15.790 -21 ■ 275 1. 00 42.14 C
ATOM 964 0 ASP A 131 -18.031 -16.731 -21.537 1. ,00 41.99 0ATOM 964 0 ASP A 131 -18.031 -16.731 -21.537 1., 00 41.99 0
ATOM 965 N GLU A 132 - 17.330 -15.121 -20.130 1. 00 40.20 ΝATOM 965 N GLU A 132-17.330 -15.121 -20.130 1. 00 40.20 Ν
ATOM 966 CA 6LU A 132 -18.221 -15.504 -19.033 1. ,00. 39.13 CATOM 966 CA 6LU A 132 -18.221 -15.504 -19.033 1., 00. 39.13 C
ATOM 967 CB GLU A 132 -17.835 -14.721 -17.781 1. .00 38.28 CATOM 967 CB GLU A 132 -17.835 -14.721 -17.781 1. .00 38.28 C
ATOM 968 CG GLU A 132 - 18.765 -14.891 -16.612 1. ,00 38.31 CATOM 968 CG GLU A 132-18.765 -14.891 -16.612 1., 00 38.31 C
ATOM 969 CD GLU A 132 -18.437 -13.917 -15.509 1, .00 39.35 CATOM 969 CD GLU A 132 -18.437 -13.917 -15.509 1, .00 39.35 C
ATOM 970 0E1 GLU A 132 - ΐ9· 105 -12.863 -15.437 1. .00 41.21 0ATOM 970 0E1 GLU A 132-ΐ9 · 105 -12.863 -15.437 1. .00 41.21 0
ATOM 971 0E2 GLU A 132 -17.506 -14.200 -14.721 1, .00 40.44 0ATOM 971 0E2 GLU A 132 -17.506 -14.200 -14.721 1, .00 40.44 0
ATOM 972 C GLU A 132 -19.701 -15.277 -19.332 1, .00 36.65 CATOM 972 C GLU A 132 -19.701 -15.277 -19.332 1, .00 36.65 C
ATOM 973 0 GLU A 132 -20.075 -14.231 -19.842 1, .00 36.63 0ATOM 973 0 GLU A 132 -20.075 -14.231 -19.842 1, .00 36.63 0
ATOM 974 N ARG A 133 -20.543 -16.252 -19.002 1 .00 35.90 ΝATOM 974 N ARG A 133 -20.543 -16.252 -19.002 1 .00 35.90 Ν
ATOM 975 CA ARG A 133 - 21.975 -16.124 -19.259 1 .00 37.32 CATOM 975 CA ARG A 133-21.975 -16.124 -19.259 1 .00 37.32 C
ATOM 976 CB ARG A 133 -22.559 -17.449 -19.757 1 ■ 00 40.69 CATOM 976 CB ARG A 133 -22.559 -17.449 -19.757 1 ■ 00 40.69 C
ATOM 977 CG ARG A 133 -22.102 -17.852 1 .00 46.68 CATOM 977 CG ARG A 133 -22.102 -17.852 1 .00 46.68 C
ATOM 978 CD ARG A 133 - 23.031 -18.900 - 21.760 1 ■ 00 50.94 CATOM 978 CD ARG A 133-23.031 -18.900-21.760 1 ■ 00 50.94 C
ATOM 979 NE ARG A 133 -22.733 -19.135 - 23.171 1 ■ 00 55.09 ΝATOM 979 NE ARG A 133 -22.733 -19.135-23.171 1 ■ 00 55.09 Ν
ATOM 980 CZ ARG A 133 - 22.676 -20.340 -23.732 1 .00 56.56 CATOM 980 CZ ARG A 133-22.676 -20.340 -23.732 1 .00 56.56 C
ATOM 981 NH1 ARG A 133 -22.395 -20.459 -25.022 1 .00 56.57 ΝATOM 981 NH1 ARG A 133 -22.395 -20.459 -25.022 1 .00 56.57 Ν
ATOM 982 NH2 ARG A 133 -22.902 -21.425 -23.002 1 ■ 00 58.35 ΝATOM 982 NH2 ARG A 133 -22.902 -21.425 -23.002 1 ■ 00 58.35 Ν
ATOM 983 C ARG A 133 -22.743 -15.672 -18.023 1 .00 35.66 C ATOM 984 0 ARG A 133 -23.813 -15.074 -18.131 1.00 34.49 0ATOM 983 C ARG A 133 -22.743 -15.672 -18.023 1 .00 35.66 C ATOM 984 0 ARG A 133 -23.813 -15.074 -18.131 1.00 34.49 0
ATOM 985 N MET A 134 -22.196 -15.970 -16. 850 1. 00 33.33 NATOM 985 N MET A 134 -22.196 -15.970 -16. 850 1. 00 33.33 N
ATOM 986 CA MET A 134 - 22.781 -15.508 -15. 603 1. 00 32.90 GATOM 986 CA MET A 134-22.781 -15.508 -15. 603 1. 00 32.90 G
ATOM 987 CB MET A 134 -23.961 -16.394 -15. 200 1. 00 35.30 CATOM 987 CB MET A 134 -23.961 -16.394 -15. 200 1. 00 35.30 C
ATOM 988 CG MET A 134 -24.646 -15.948 -13. 916 1. 00 38.38 CATOM 988 CG MET A 134 -24.646 -15.948 -13. 916 1. 00 38.38 C
ATOM 989 SD MET A 134 - 26.128 -16.906 -13. 555 1. 00 44.30 SATOM 989 SD MET A 134-26.128 -16.906 -13. 555 1. 00 44.30 S
ATOM 990 CE MET A 134 -27.083一 16.618 -15. 027 1. 00 45..63 CATOM 990 CE MET A 134 -27.083 1 16.618 -15. 027 1. 00 45..63 C
ATOM 991 C MET A 134 -21.759 -15.495 -14. 481 1. 00 30.80 CATOM 991 C MET A 134 -21.759 -15.495 -14. 481 1. 00 30.80 C
ATOM 992 0 MET A 134 - 20, 949 -16.412 -14. 353 1. 00 30.74 0ATOM 992 0 MET A 134-20, 949 -16.412 -14. 353 1. 00 30.74 0
ATOM 993 N ALA A 135 -21.79o t6 -14.438 - 13. 679 1. 00 28.00 NATOM 993 N ALA A 135 -21.79o t6 -14.438-13. 679 1. 00 28.00 N
ATOM 994 CA ALA A 135 -21.058一 14.404 -12. 430 1. 00 27.79 CATOM 994 CA ALA A 135 -21.058 One 14.404 -12. 430 1. 00 27.79 C
ATOM 995 CB ALA A 135 -20.245 - 13· 119 -12. 340 1. 00 28.33 CATOM 995 CB ALA A 135 -20.245-13 119 -12. 340 1. 00 28.33 C
ATOM 996 C ALA A 135 -22.044 -14.490 -11. 269 1. 00 26.83 . CATOM 996 C ALA A 135 -22.044 -14.490 -11. 269 1. 00 26.83. C
ATOM 997 0 ALA A 135 -23.008 - 13.728 -11. 213 1. 00 25.66 0ATOM 997 0 ALA A 135 -23.008-13.728 -11. 213 1.00 25.66 0
ATOM 998 N LEU A 136 -21.814 -15.428 -10. 355 1. 00 25.31 NATOM 998 N LEU A 136 -21.814 -15.428 -10. 355 1. 00 25.31 N
ATOM 999 CA LEU A 136 -22.630 -15.515 -9. 148 1. 00 24.44 CATOM 999 CA LEU A 136 -22.630 -15.515 -9. 148 1. 00 24.44 C
ATOM 1000 CB LEU A 136 -23.102 -16.950 - 8· 899 1. ,00 23.63 CATOM 1000 CB LEU A 136 -23.102 -16.950-8 899 1., 00 23.63 C
ATOM 1001 CG LEU A 136 -24.169 -17.617 - 9. 787 1. ,00 26.04 CATOM 1001 CG LEU A 136 -24.169 -17.617-9. 787 1., 00 26.04 C
ATOM 1002 CD1 LEU A 136 -25.462 -16.808 - 9. 752 1. ,00 25.98 CATOM 1002 CD1 LEU A 136 -25.462 -16.808-9. 752 1., 00 25.98 C
ATOM 1003 CD2 LEU A 136 - 23.664 -17.742 -11. 201 1. ,00 27.02 CATOM 1003 CD2 LEU A 136-23.664 -17.742 -11. 201 1., 00 27.02 C
ATOM 1004 C LEU A 136 -21.809 -15.044 - 7. 958 1. ,00 24.74 CATOM 1004 C LEU A 136 -21.809 -15.044-7. 958 1., 00 24.74 C
ATOM 1005 0 LEU A 136 - 20.890 -15.730 -7. 525 1. ,00 26.39 0ATOM 1005 0 LEU A 136-20.890 -15.730 -7. 525 1., 00 26.39 0
ATOM 1006 N ILE A 137 -22.136 - 13· 867 -7.437 1, ,00 24.23 NATOM 1006 N ILE A 137 -22.136-13 867 -7.437 1,, 00 24.23 N
ATOM 1007 CA ILE A 137 -21.465 -13.345 - 6. 251 1. .00 23.84 CATOM 1007 CA ILE A 137 -21.465 -13.345-6. 251 1. .00 23.84 C
ATOM 1008 CB ILE A 137 -21.639 -11.818 - 6. 159 1. .00 23.22 CATOM 1008 CB ILE A 137 -21.639 -11.818-6. 159 1. .00 23.22 C
ATOM 1009 CG2 ILE A 137 -21.076 - 11.302 一 4. 852 1, .00 21.78 CATOM 1009 CG2 ILE A 137 -21.076-11.302 One 4.852 1, .00 21.78 C
ATOM 1010 CG1 ILE A 137 -20.976 - 11.154 -7. 363 1. .00 24.95 CATOM 1010 CG1 ILE A 137 -20.976-11.154 -7. 363 1. .00 24.95 C
ATOM 1011 CD1 ILE A 137 -9.660 -7. 404 1, .00 24.99 CATOM 1011 CD1 ILE A 137 -9.660 -7. 404 1, .00 24.99 C
ATOM 1012 C ILE A 137 -22.123 -13.986 -5. 034 1, .00 23.08 CATOM 1012 C ILE A 137 -22.123 -13.986 -5. 034 1, .00 23.08 C
ATOM 1013 0 ILE A 137 -23.349 -14.050 -4. 964 1 .00 23.69 0ATOM 1013 0 ILE A 137 -23.349 -14.050 -4. 964 1 .00 23.69 0
ATOM 1014 N VAL A 138 -21.327一 14.481 -4. 090 1, .00 21.49 NATOM 1014 N VAL A 138 -21.327 One 14.481 -4. 090 1, .00 21.49 N
ATOM 1015 CA VAL A 138 -21.896 -15.024 - 2. 863 1, .00 21.50 CATOM 1015 CA VAL A 138 -21.896 -15.024-2. 863 1, .00 21.50 C
ATOM 1016 CB VAL A 138 - 21.707 -16.564 -2. 730 1 .00 23.58 CATOM 1016 CB VAL A 138-21.707 -16.564 -2. 730 1 .00 23.58 C
ATOM 1017 C61 VAL A 138 -22.428 -17.280 - 3. 871 1, .00 23.19 CATOM 1017 C61 VAL A 138 -22.428 -17.280-3. 871 1, .00 23.19 C
ATOM 1018 CG2 VAL A 138 -20.225 -16.921 - 2. 701 1 .00 24.58 CATOM 1018 CG2 VAL A 138 -20.225 -16.921-2.701 1 .00 24.58 C
ATOM 1019 C VAL A 138 一 21.326一 14.371 -1. 628 1 .00 22.31 C ATOM 1020 0 VAL A 138 -20.115一 14.160 -1.510 1.00 21.84 0ATOM 1019 C VAL A 138 1 21.326 1 14.371 -1. 628 1 .00 22.31 C ATOM 1020 0 VAL A 138 -20.115 One 14.160 -1.510 1.00 21.84 0
ATOM 1021 N ASP A 139 -22.223 -14.051 -0.705 1. 00 22.57 NATOM 1021 N ASP A 139 -22.223 -14.051 -0.705 1.00 22.57 N
ATOM 1022 CA ASP A 139 -21.857 -13.371 0.522 1. 00 23.89 CATOM 1022 CA ASP A 139 -21.857 -13.371 0.522 1. 00 23.89 C
ATOM 1023 CB ASP A 139 - 21.600 -11.890 0.234 1. 00 25.43 CATOM 1023 CB ASP A 139-21.600 -11.890 0.234 1. 00 25.43 C
ATOM 1024 C6 ASP A 139 -20.818 -11.210 1. 331 1. 00 28.01 CATOM 1024 C6 ASP A 139 -20.818 -11.210 1. 331 1. 00 28.01 C
ATOM 1025 0D1 ASP A 139 - 20.298 -11.908 2. 226 1. 00 31.10 0ATOM 1025 0D1 ASP A 139-20.298 -11.908 2. 226 1. 00 31.10 0
ATOM 1026 0D2 ASP A 139 -20.712 -9.972 1. 298 1. 00 31.13 0ATOM 1026 0D2 ASP A 139 -20.712 -9.972 1. 298 1. 00 31.13 0
ATOM 1027 C ASP A 139 -23.042 -13.530 1. 461 1. 00 23.67 CATOM 1027 C ASP A 139 -23.042 -13.530 1. 461 1. 00 23.67 C
ATOM 1028 0 ASP A 139 -24.174 -13.226 1. 098 1. 00 22.47 0ATOM 1028 0 ASP A 139 -24.174 -13.226 1. 098 1.00 22.47 0
ATOM 1029 N PRO A 140 -22.796 -14.018 2. 681 1. 00 23.72 NATOM 1029 N PRO A 140 -22.796 -14.018 2. 681 1. 00 23.72 N
ATOM 1030 CD PRO A 140 - 21 · 479 -14.367 3. 243 1. 00 23.10 CATOM 1030 CD PRO A 140-21 479 -14.367 3.243 1. 00 23.10 C
ATOM 1031 CA PRO A 140 -23.897 -14.384 3. 579 1. 00 22.97 CATOM 1031 CA PRO A 140 -23.897 -14.384 3. 579 1.00 22.97 C
ATOM 1032 CB PRO A 140 -23.183 -14.909 4. 827 1. 00 25.21 CATOM 1032 CB PRO A 140 -23.183 -14.909 4. 827 1.00 25.21 C
ATOM 1033 CG PRO A 140 -21■ 822 -15.338 4. 336 1. 00 23.06 CATOM 1033 CG PRO A 140 -21 822 -15.338 4. 336 1.00 23.06 C
ATOM 1034 C PRO A 140 -24.872 -13.241 3. 905 1. 00 22.79 CATOM 1034 C PRO A 140 -24.872 -13.241 3. 905 1. 00 22.79 C
ATOM 1035 0 PRO A 140 -26.077 - 13.437 3. 884 1. ,00 21.31 0ATOM 1035 0 PRO A 140 -26.077-13.437 3. 884 1., 00 21.31 0
ATOM 1036 N MET A 141 -24.355 -12.052 4. 193 1. 00 23.28 NATOM 1036 N MET A 141 -24.355 -12.052 4. 193 1. 00 23.28 N
ATOM 1037 CA MET A 141 -25.205 -10.950 4. 639 1. ,00 25.36 CATOM 1037 CA MET A 141 -25.205 -10.950 4. 639 1., 00 25.36 C
ATOM 1038 CB MET A 141 - 24.849 - 10.588 6. 080 1. 00 24.06 CATOM 1038 CB MET A 141-24.849-10.588 6. 080 1.00 24.06 C
ATOM 1039 CG MET A 141 - 24.959 -11.762 7. 044 1. ,00 24.73 CATOM 1039 CG MET A 141-24.959 -11.762 7. 044 1., 00 24.73 C
ATOM 1040 SD MET A 141 -24.744 -11.252 8. 757 1. ,00 32.16 SATOM 1040 SD MET A 141 -24.744 -11.252 8. 757 1., 00 32.16 S
ATOM 1041 CE MET A 141 -23.113 -10.474 8. 704 1. ,00 28.26 CATOM 1041 CE MET A 141 -23.113 -10.474 8. 704 1., 00 28.26 C
ATOM 1042 C MET A 141 -25.122 -9.701 3.755 1. .00 26.24 CATOM 1042 C MET A 141 -25.122 -9.701 3.755 1. .00 26.24 C
ATOM 1043 0 MET A 141 -24.039 -9.195 3. 474 1. .00 26.85 0ATOM 1043 0 MET A 141 -24.039 -9.195 3.474 1. .00 26.85 0
ATOM 1044 N LEU A 142 -26.275 -9.207 3. 317 1. .00 26.88 NATOM 1044 N LEU A 142 -26.275 -9.207 3. 317 1. .00 26.88 N
ATOM 1045 CA LEU A 142 -26.334 -7.929 2. 612 1, .00 27.69 CATOM 1045 CA LEU A 142 -26.334 -7.929 2. 612 1, .00 27.69 C
ATOM 1046 CB LEU A 142 -27.224 -8.043 1. 363 1, .00 27.40 CATOM 1046 CB LEU A 142 -27.224 -8.043 1. 363 1, .00 27.40 C
ATOM 1047 CG LEU A 142 -27.127 -6.898 0. 346 1. .00 26.97 CATOM 1047 CG LEU A 142 -27.127 -6.898 0. 346 1. .00 26.97 C
ATOM 1048 CD1 LEU A 142 -25.838 -7.042 -0. 463 1, .00 27.39 CATOM 1048 CD1 LEU A 142 -25.838 -7.042 -0. 463 1, .00 27.39 C
ATOM' 1049 CD2 LEU A 142 -28.330 -6.909 -0. 580 1, .00 24.85 CATOM '1049 CD2 LEU A 142 -28.330 -6.909 -0. 580 1, .00 24.85 C
ATOM 1050 C LEU A 142 -26, 923 - 6.901 3. 575 1. .00 28.72 CATOM 1050 C LEU A 142 -26, 923-6.901 3.575 1. .00 28.72 C
ATOM 1051 0 LEU A 142 -28.134 -6.878 3. 790 1, .00 28.83 0ATOM 1051 0 LEU A 142 -28.134 -6.878 3. 790 1, .00 28.83 0
ATOM 1052 N ALA A 143 -26.063 -6.065 4. 157 1 .00 28.42 NATOM 1052 N ALA A 143 -26.063 -6.065 4.157 1 .00 28.42 N
ATOM 1053 CA ALA A 143 -26.486 -5.084 5. 156 1, .00 27.59 CATOM 1053 CA ALA A 143 -26.486 -5.084 5. 156 1, .00 27.59 C
ATOM 1054 CB ALA A 143 -25.503 -5.068 6. ,326 1 .00 26.26 CATOM 1054 CB ALA A 143 -25.503 -5.068 6., 326 1 .00 26.26 C
ATOM 1055 C ALA A 143 -26.606 -3.685 4. 554 1 .00 28.49 C ATOM 1056 0 ALA A 143 -27.712 -3.192 4.352 1.00 29.15 0ATOM 1055 C ALA A 143 -26.606 -3.685 4.554 1 .00 28.49 C ATOM 1056 0 ALA A 143 -27.712 -3.192 4.352 1.00 29.15 0
ATOM 1057 N THR A 144 -25.473 -3.047 4.266 1. 00 28.69 ΝATOM 1057 N THR A 144 -25.473 -3.047 4.266 1. 00 28.69 Ν
ATOM 1058 CA THR A 144 -25.487 -1.773 3.551 1. 00 29.46 CATOM 1058 CA THR A 144 -25.487 -1.773 3.551 1. 00 29.46 C
ATOM 1059 CB THR A 144 - 24.337 -0.850 4.005 1. 00 28.62 CATOM 1059 CB THR A 144-24.337 -0.850 4.005 1.00 28.62 C
ATOM 1060 061 THR A 144 -23.080 -1■ 464 3.699 1. 00 27.28 0ATOM 1060 061 THR A 144 -23.080 -1 464 3.699 1. 00 27.28 0
ATOM 1061 C62 THR A 144 -24.423 - 0.591 5.500 1. 00 25.91 CATOM 1061 C62 THR A 144 -24.423-0.591 5.500 1. 00 25.91 C
ATOM 1062 C THR A 144 -25.362 -2.008 2.046 1. 00 31.06 CATOM 1062 C THR A 144 -25.362 -2.008 2.046 1. 00 31.06 C
ATOM 1063 0 THR A 144 - 25.811 1.231 1. 00 31.30 0ATOM 1063 0 THR A 144-25.811 1.231 1. 00 31.30 0
ATOM 1064 N 6LY A 1 5 -24.759 -3.134 1.682 1. 00 31.29 ΝATOM 1064 N 6LY A 1 5 -24.759 -3.134 1.682 1. 00 31.29 Ν
ATOM 1065 CA GLY A 145 -24.611 -3.473 0.280 1. 00 29.77 CATOM 1065 CA GLY A 145 -24.611 -3.473 0.280 1. 00 29.77 C
ATOM 1066 C GLY A 145 -23.293 -2.997 - 0.299 1. 00 29.67 C ATOM 1066 C GLY A 145 -23.293 -2.997-0.299 1. 00 29.67 C
I I
ATOM 1067 .0 GLY A 145 . -22.992 -3.265 -1.458 1. 00 30.57 0ATOM 1067 .0 GLY A 145. -22.992 -3.265 -1.458 1. 00 30.57 0
ATOM 1068 GLY A 146 -22.504 - 2.291 0.508 1. 00 27.59 .ATOM 1068 GLY A 146 -22.504-2.291 0.508 1.00 27.59.
ATOM 1069 CA GLY A 146 -21■ 259 - 1.728 0.015 1. 00 27.53 CATOM 1069 CA GLY A 146 -21 ■ 259-1.728 0.015 1. 00 27.53 C
ATOM 1070 C GLY A 146 -20.320 -2.762 -0.58 to0 1. 00 26.57 CATOM 1070 C GLY A 146 -20.320 -2.762 -0.58 to0 1. 00 26.57 C
ATOM 1071 0 GLY A 146 - 19.746 - 2.554 -1.652 1. 00 26.93 0ATOM 1071 0 GLY A 146-19.746-2.554 -1.652 1.00 26.93 0
ATOM 1072 N SER A 147 -20.166 -3.886 0.111 1. ,00 26.35 ΝATOM 1072 N SER A 147 -20.166 -3.886 0.111 1., 00 26.35 Ν
ATOM 1073 CA SER A 147 -19.260 -4.928 - 0.339 1. ,00 26.26 CATOM 1073 CA SER A 147 -19.260 -4.928-0.339 1., 00 26.26 C
ATOM 1074 CB SER A 147 -19.205 -6.049 0.695 1. ,00 26.85 CATOM 1074 CB SER A 147 -19.205 -6.049 0.695 1., 00 26.85 C
ATOM 1075 OG SER A 147 -18.561 - 5.604 1.872 1. ,00 30.30 0ATOM 1075 OG SER A 147 -18.561-5.604 1.872 1., 00 30.30 0
ATOM 1076 C SER A 147 -19.680 -5.482 1. ,00 24.62 CATOM 1076 C SER A 147 -19.680 -5.482 1., 00 24.62 C
ATOM 1077 0 SER A 147 -18.870 -5.559 -2.609 1. .00 25.52 0ATOM 1077 0 SER A 147 -18.870 -5.559 -2.609 1. .00 25.52 0
ATOM 1078 N VAL A 148 -20.951 -5.848 - ΐ· 830 1. .00 23.99 ΝATOM 1078 N VAL A 148 -20.951 -5.848-ΐ 830 1. .00 23.99 Ν
ATOM 1079 CA VAL A 148 -21.452 -6.411 -3.077 1, .00 24.37 CATOM 1079 CA VAL A 148 -21.452 -6.411 -3.077 1, .00 24.37 C
ATOM 1080 CB VAL A 148 - 22.880 - 6.953 -2.892 1, .00 24.82 CATOM 1080 CB VAL A 148-22.880-6.953 -2.892 1, .00 24.82 C
ATOM 1081 C61 VAL A 148 -23.555 -7.156 -4.239 1. .00 23.48 CATOM 1081 C61 VAL A 148 -23.555 -7.156 -4.239 1. .00 23.48 C
ATOM 1082 CG2 VAL A 148 - 22.822 -8.279 -2.141 1, .00 26.31 . CATOM 1082 CG2 VAL A 148-22.822 -8.279 -2.141 1, .00 26.31. C
ATOM 1083 C VAL A 1 8 -21.429 -5.394 -4.219 1, .00 26.46 CATOM 1083 C VAL A 1 8 -21.429 -5.394 -4.219 1, .00 26.46 C
ATOM 1084 0 VAL A 148 -20.964 -5.695 -5.322 1 .00 25.31 0ATOM 1084 0 VAL A 148 -20.964 -5.695 -5.322 1 .00 25.31 0
ATOM 1085 N ILE A 149 -21.916 -4.189 -3.949 1 .00 27.36 ΝATOM 1085 N ILE A 149 -21.916 -4.189 -3.949 1 .00 27.36 Ν
ATOM 1086 CA ILE A 149 -21.887 - 3.113 -4.934 1 .0028.19 CATOM 1086 CA ILE A 149 -21.887-3.113 -4.934 1 .0028.19 C
ATOM 1087 CB ILE A 149 -22.487 - 1.811 - 4.344 1 .00 27.60 CATOM 1087 CB ILE A 149 -22.487-1.811-4.344 1 .00 27.60 C
ATOM 1088 CG2 ILE A 149 - 22.320 -0.665 -5.330 1 ■ 00 27.42 CATOM 1088 CG2 ILE A 149-22.320 -0.665 -5.330 1 ■ 00 27.42 C
ATOM 1089 CG1 ILE A 149 -23.964 -2.027 - 4.014 1 .00 25.12 CATOM 1089 CG1 ILE A 149 -23.964 -2.027-4.014 1 .00 25.12 C
ATOM 1090 CD1 ILE A 149 - 24.594 - 0.905 -3.231 1 .00 24.07 CATOM 1090 CD1 ILE A 149-24.594-0.905 -3.231 1 .00 24.07 C
ATOM 1091 C ILE A 149 —20.466 -2.828 - 5.451 1 .00 29.44 C ATOM 1092 0 ILE A 149 -20.242 -2.741 -6.660 1.00 29.63 0ATOM 1091 C ILE A 149 —20.466 -2.828-5.451 1 .00 29.44 C ATOM 1092 0 ILE A 149 -20.242 -2.741 -6.660 1.00 29.63 0
ATOM 1093 N ALA A 150 -19.505 -2.691 -4.545 1. 00 28.62 ΝATOM 1093 N ALA A 150 -19.505 -2.691 -4.545 1. 00 28.62 Ν
ATOM 1094 CA ALA A 150 -18.135 -2.445 -4.969 1. 00 30.02 CATOM 1094 CA ALA A 150 -18.135 -2.445 -4.969 1.00 30.02 C
ATOM 1095 CB ALA A 150 -17.269 -2.119 - 3.767 1. 00 32.61 CATOM 1095 CB ALA A 150 -17.269 -2.119-3.767 1. 00 32.61 C
ATOM 1096 C ALA A 150 -17.570 - 3.654 -5.720 1. 00 31.70 CATOM 1096 C ALA A 150 -17.570-3.654 -5.720 1.00 31.70 C
ATOM 1097 0 ALA A 150 -16.762 -3.498 -6.631 1. 00 31.79 0ATOM 1097 0 ALA A 150 -16.762 -3.498 -6.631 1.00 31.79 0
ATOM 1098 N THR A 151 -18.003 -4.859 -5.347 1. 00 31.90 ΝATOM 1098 N THR A 151 -18.003 -4.859 -5.347 1. 00 31.90 Ν
ATOM 1099 CA THR A 151 -17.599 - 6.066 - 6.067 1. 00 27.72 CATOM 1099 CA THR A 151 -17.599-6.066-6.067 1. 00 27.72 C
ATOM 1100 CB THR A 151 -18.062 -7.342 - 5.333 1. 00 28.79 CATOM 1100 CB THR A 151 -18.062 -7.342-5.333 1. 00 28.79 C
ATOM 1101 0G1 THR A 151 -17.285 -7.520 -4.144 1. 00 30.65 0ATOM 1101 0G1 THR A 151 -17.285 -7.520 -4.144 1.00 30.65 0
ATOM 1102 C62 THR A 151 -17.910 -8.559 - 6.224 1. 00 24.43 CATOM 1102 C62 THR A 151 -17.910 -8.559-6.224 1.00 24.43 C
ATOM 1103 . C THR A 151 -18.170 -6.092 - 7.478 1. 00 27.57 CATOM 1103. C THR A 151 -18.170 -6.092-7.478 1. 00 27.57 C
ATOM 1104 0 THR A 151 -17.459 -6.400 -8.430 1. 00 27.10 0ATOM 1104 0 THR A 151 -17.459 -6.400 -8.430 1.00 27.10 0
ATOM 1105 N ILE A 152 -19.458 -5.785 - 7.613 1. 00 28.38 ΝATOM 1105 N ILE A 152 -19.458 -5.785-7.613 1. 00 28.38 Ν
ATOM 1106 CA ILE A 152 -20.094 - 5.728 -8.9 0029 1. 00 28.41 CATOM 1106 CA ILE A 152 -20.094-5.728 -8.9 0029 1. 00 28.41 C
ATOM 1107 CB ILE A 152 -21.593 -5.341 -8.821 1. 00 27.17 CATOM 1107 CB ILE A 152 -21.593 -5.341 -8.821 1. 00 27.17 C
ATOM 1108 CG2 ILE A 152 -22.134 -4.911 - 10.189 1. 00 25.68 C η ATOM 1108 CG2 ILE A 152 -22.134 -4.911-10.189 1. 00 25.68 C η
ATOM 1109 CG1 ILE A 152 -22.393 -6.532 -8.282 1. ,00 25.31 C ATOM 1109 CG1 ILE A 152 -22.393 -6.532 -8.282 1., 00 25.31 C
ATOM 1110 CD1 ILE A 152 -23.757 -6.169 -7.740 1. 00 20.72 CATOM 1110 CD1 ILE A 152 -23.757 -6.169 -7.740 1. 00 20.72 C
ATOM 1111 C ILE A 152 -19.380 -4.723 -9.836 1. 00 30.63 CATOM 1111 C ILE A 152 -19.380 -4.723 -9.836 1. 00 30.63 C
ATOM 1112 0 ILE A 152 -19.235 -4.955 -11.039 1. .00 29.20 0ATOM 1112 0 ILE A 152 -19.235 -4.955 -11.039 1. .00 29.20 0
ATOM 1113 N ASP A 153 - 18.924 -3.616 -9.255 1. ,00 ΝATOM 1113 N ASP A 153-18.924 -3.616 -9.255 1., 00 Ν
ATOM 1114 CA ASP A 153 - 18.121 - 2.655 -10.000 1. .00 34.27 CATOM 1114 CA ASP A 153-18.121-2.655 -10.000 1. .00 34.27 C
ATOM 1115 CB ASP A 153 -17.611 -1.548 -9.071 1. ,00 35.62 CATOM 1115 CB ASP A 153 -17.611 -1.548 -9.071 1., 00 35.62 C
ATOM 1116 CG ASP A 153 -18.708 -0.577 -8. «62 1. .00 38.46 CATOM 1116 CG ASP A 153 -18.708 -0.577 -8. «62 1. .00 38.46 C
ATOM 1117 obi ASP A 153 - 19.794 -0.613 - 9.270 1. .00 38.44 0ATOM 1117 obi ASP A 153-19.794 -0.613-9.270 1. .00 38.44 0
ATOM 1118 0D2 ASP A 153 -18. 87 0.226 -7.732 1, .00 41.84 0ATOM 1118 0D2 ASP A 153 -18. 87 0.226 -7.732 1, .00 41.84 0
ATOM 1119 C ASP A 153 -16.938 - 3.355 -10.672 1. .00 34.69 CATOM 1119 C ASP A 153 -16.938-3.355 -10.672 1. .00 34.69 C
ATOM 1120 0 ASP A 153 -16.716 -3.197 1, .00 34.95 0ATOM 1120 0 ASP A 153 -16.716 -3.197 1, .00 34.95 0
ATOM 1121 N LEU A 154 -16.193 -4.132 -9.890 1, .00 34.35 ΝATOM 1121 N LEU A 154 -16.193 -4.132 -9.890 1, .00 34.35 Ν
ATOM 1122 CA LEU A 154 -15.042 -4.880 -10.399 1, .00 34.97 GATOM 1122 CA LEU A 154 -15.042 -4.880 -10.399 1, .00 34.97 G
ATOM 1123 CB LEU A 154 -14.389 - 5.686 -9.276 1, .00 37.49 CATOM 1123 CB LEU A 154 -14.389-5.686 -9.276 1, .00 37.49 C
ATOM 1124 CG LEU A 154 -13.265 -5.055 - 8.459 1 • 00 38.07 CATOM 1124 CG LEU A 154 -13.265 -5.055-8.459 1 • 00 38.07 C
ATOM 1125 CD1 LEU A 154 -12.967 -5.941 -7.266 1 .00 39.02 CATOM 1125 CD1 LEU A 154 -12.967 -5.941 -7.266 1 .00 39.02 C
ATOM 1126 CD2 LEU A 154 -12.025 -4.898 -9.316 1 ■ 00 37.30 GATOM 1126 CD2 LEU A 154 -12.025 -4.898 -9.316 1 ■ 00 37.30 G
ATOM 1127 G LEU A 154 -15.407 一 5.828 -11.530 1 ■ 00 33.09 C ATOM 1128 0 LEU A 154 -14.765 -5.824 -12.572 1.00 32.88 0ATOM 1127 G LEU A 154 -15.407 One 5.828 -11.530 1 ■ 00 33.09 C ATOM 1128 0 LEU A 154 -14.765 -5.824 -12.572 1.00 32.88 0
ATOM 1129 N LEU A 155 -16.435 -6.644 -11.331 1. 00 33.00 NATOM 1129 N LEU A 155 -16.435 -6.644 -11.331 1.00 33.00 N
ATOM 1130 CA LEU A 155 -16.816 -7.609 -12.353 1. 00 32.80 CATOM 1130 CA LEU A 155 -16.816 -7.609 -12.353 1. 00 32.80 C
ATOM 1131 CB LEU A 155 一 17.978 -8.482 -11.868 1. 00 30.43 CATOM 1131 CB LEU A 155 i 17.978 -8.482 -11.868 1. 00 30.43 C
ATOM 1132 CG LEU A 155 -17.710 - 9.429 - 10.695 1. 00 29.67 CATOM 1132 CG LEU A 155 -17.710-9.429-10.695 1. 00 29.67 C
ATOM 1133 CD1 LEU A 155 -18.885 - 10· 376 -10.521 1. 00 28.67 CATOM 1133 CD1 LEU A 155 -18.885-10376 -10.521 1.00 28.67 C
ATOM 1134 CD2 LEU A 155 -16.436 -10.214 - 10.953 1. 00 30.06 CATOM 1134 CD2 LEU A 155 -16.436 -10.214-10.953 1. 00 30.06 C
ATOM 1135 C LEU A 155 -17.193 -6.934 -13.673 1. 00 35.17 CATOM 1135 C LEU A 155 -17.193 -6.934 -13.673 1. 00 35.17 C
ATOM 1136 0 LEU A 155 -16.853 -7.430 -14.750 1. 00 35.88 0ATOM 1136 0 LEU A 155 -16.853 -7.430 -14.750 1.00 35.88 0
ATOM 1137 N LYS A 156 -17.900 -5.809 - 13.592 1. 00 37.38 NATOM 1137 N LYS A 156 -17.900 -5.809-13.592 1. 00 37.38 N
ATOM 1138 CA LYS A 156 -18.368 -5.116 -14.789 1. 00 38.29 CATOM 1138 CA LYS A 156 -18.368 -5.116 -14.789 1. 00 38.29 C
ATOM 1139 ■CB LYS A 156 -19.343 -3.993 -14.412 1. 00 38.41 CATOM 1139 CB LYS A 156 -19.343 -3.993 -14.412 1. 00 38.41 C
ATOM 1140 CG LYS A 156 -20.734 - 4.464 -13.994 1. 00 39.21 CATOM 1140 CG LYS A 156 -20.734-4.464 -13.994 1. 00 39.21 C
ATOM 1141 CD LYS A 156 -21.567 -3.299 -13.462 1. 00 38.06 CATOM 1141 CD LYS A 156 -21.567 -3.299 -13.462 1. 00 38.06 C
ATOM 1142 CE LYS A 156 - 23.008 -3.699 -13.199 1. 00 37.41 CATOM 1142 CE LYS A 156-23.008 -3.699 -13.199 1. 00 37.41 C
ATOM 1143 NZ LYS A 156 -23.804 -3.775 -14.449 1. 00 36.57 NATOM 1143 NZ LYS A 156 -23.804 -3.775 -14.449 1. 00 36.57 N
ATOM 1144 C LYS A 156 -17.203 - 4.533 -15.590 1. ,00 38.07 CATOM 1144 C LYS A 156 -17.203-4.533 -15.590 1., 00 38.07 C
ATOM 1145 0 LYS A 156 -17.236 -4.505 -16.818 1. ,00 37.41 0ATOM 1145 0 LYS A 156 -17.236 -4.505 -16.818 1., 00 37.41 0
ATOM 1146 N LYS A 157 -16.175 -4.067 - 14.894 1. ,00 39.72 NATOM 1146 N LYS A 157 -16.175 -4.067-14.894 1., 00 39.72 N
ATOM 1147 CA LYS A 157 -15.020 -3.494 -15.570 1. ,00 42.30 CATOM 1147 CA LYS A 157 -15.020 -3.494 -15.570 1., 00 42.30 C
ATOM 1148 CB LYS A 157 -14.143 -2.752 -14.563 1. .00 43.51 CATOM 1148 CB LYS A 157 -14.143 -2.752 -14.563 1. .00 43.51 C
ATOM 1149 CG LYS A 157 -13.136 -1.816 -15.200 1. ,00 47.32 CATOM 1149 CG LYS A 157 -13.136 -1.816 -15.200 1., 00 47.32 C
ATOM 1150 CD LYS A 157 -12.267 -1.141 -14.149 1. .00 50.32 CATOM 1150 CD LYS A 157 -12.267 -1.141 -14.149 1. .00 50.32 C
ATOM 1151 CE LYS A 157 -11.205 -0.265 -14.798 1. .00 52.57 CATOM 1151 CE LYS A 157 -11.205 -0.265 -14.798 1. .00 52.57 C
ATOM 1152 NZ LYS A 157 -10.321 0.387 -13.785 1, .00 55.20 NATOM 1152 NZ LYS A 157 -10.321 0.387 -13.785 1, .00 55.20 N
ATOM 1153 C LYS A 157 -14.214 -4.593 -16.272 1. .00 42.57 CATOM 1153 C LYS A 157 -14.214 -4.593 -16.272 1. .00 42.57 C
ATOM 1154 0 LYS A 157 -13.716 - 4.406 - 17.387 1, .00 42.10 0ATOM 1154 0 LYS A 157 -13.716-4.406-17.387 1, .00 42.10 0
ATOM 1155 N ALA A 158 -14.103 -5.744 -15.616 1, .00 41.89 NATOM 1155 N ALA A 158 -14.103 -5.744 -15.616 1, .00 41.89 N
ATOM 1156 CA ALA A 158 -13.406 - 6.890 -16.184 1 .00 40.21 CATOM 1156 CA ALA A 158 -13.406-6.890 -16.184 1 .00 40.21 C
ATOM 1157 CB ALA A 158 -13.125 - 7.919 -15.097 1, .00 40.05 CATOM 1157 CB ALA A 158 -13.125-7.919 -15.097 1, .00 40.05 C
ATOM 1158 C ALA A 158 -14.221 -7.522 -17.309 1 .00 39.21 CATOM 1158 C ALA A 158 -14.221 -7.522 -17.309 1 .00 39.21 C
ATOM 1159 0 ALA A 158 -13.784 -8.494 -17.933 1 .00 40.14 0ATOM 1159 0 ALA A 158 -13.784 -8.494 -17.933 1 .00 40.14 0
ATOM 1160 N GLY A 159 -15.410 -6.978 -17.555 1 • 00 36.56 NATOM 1160 N GLY A 159 -15.410 -6.978 -17.555 1 • 00 36.56 N
ATOM 1161 CA 6LY A 159 - 16.176 - 7.377 - 18.723 1 .00 35.93 CATOM 1161 CA 6LY A 159-16.176-7.377-18.723 1 .00 35.93 C
ATOM 1162 C GLY A 159 -17.361 -8.299 -18.475 1 ■ 00 36.41 CATOM 1162 C GLY A 159 -17.361 -8.299 -18.475 1 ■ 00 36.41 C
ATOM 1163 0 GLY A 159 一 17.922 一 8.862 -19.426 1 .00 35.02 0 ATOM 1164 N SER A 160 -17.751 -8.459 -17.212 1.00 36.66 NATOM 1163 0 GLY A 159 1 17.922 1 8.862 -19.426 1 .00 35.02 0 ATOM 1164 N SER A 160 -17.751 -8.459 -17.212 1.00 36.66 N
ATOM 1165 CA SER A 160 -18.893 - 9.311 -16. 871 1. 00 37.49 GATOM 1165 CA SER A 160 -18.893-9.311 -16. 871 1. 00 37.49 G
ATOM 1166 CB SER A 160 -19.088 -9.375一 15. 349 1. 00 37.54 CATOM 1166 CB SER A 160 -19.088 -9.375 One 15. 349 1. 00 37.54 C
ATOM 1167 OG SER A 160 -18.470 -10.514 -14. 778 1. 00 35.10 0ATOM 1167 OG SER A 160 -18.470 -10.514 -14. 778 1. 00 35.10 0
ATOM 1168 C SER A 160 -20.167 -8.772 -17. 507 1. 00 38.27 CATOM 1168 C SER A 160 -20.167 -8.772 -17. 507 1. 00 38.27 C
ATOM 1169 0 SER A 160 -20.408 -7.562 -17. 503 1. 00 40.13 0ATOM 1169 0 SER A 160 -20.408 -7.562 -17. 503 1.00 40.13 0
ATOM 1170 N SER A 161 -20.979 -9.670 -18. 053 1. 00 38.08 NATOM 1170 N SER A 161 -20.979 -9.670 -18. 053 1. 00 38.08 N
ATOM 1171 CA SER A 161 -22.327 -9.311 -18. 464 1. 00 39.31 CATOM 1171 CA SER A 161 -22.327 -9.311 -18. 464 1. 00 39.31 C
ATOM 1172 CB SER A 161 - 22.709 -10.040 -19. 759 1. 00 40.56 CATOM 1172 CB SER A 161-22.709 -10.040 -19. 759 1. 00 40.56 C
ATOM 1173 06 SER A 161 - 22.471 -11.437 -19. 671 1. 00 41.23 0ATOM 1173 06 SER A 161-22.471 -11.437 -19. 671 1. 00 41.23 0
ATOM 1174 C SER A 161 -23.295 -9.667 -17. 339 1. 00 39.93 CATOM 1174 C SER A 161 -23.295 -9.667 -17. 339 1. 00 39.93 C
ATOM 1175 •0 SER A 161 -23.428 - 8.919 -16. 372 1. 00 43.37 0ATOM 1175 • 0 SER A 161 -23.428-8.919 -16. 372 1. 00 43.37 0
ATOM 1176 N SER A 162 -23.953一 10.814 -17. 452 1. 00 37.40 ,ATOM 1176 N SER A 162 -23.953 1 10.814 -17. 452 1. 00 37.40,
ATOM 1177 CA SER A 162 - 24.903 -11.249 -16. 440 1. 00 35.29 CATOM 1177 CA SER A 162-24.903 -11.249 -16. 440 1. 00 35.29 C
ATOM 1178 CB SER A 162 -25.572 -12.546 -16. 893 1. 00 35.74 CATOM 1178 CB SER A 162 -25.572 -12.546 -16. 893 1.00 35.74 C
ATOM 1179 06 SER A 162 -26.431 -13.052 -15. 890 1. 00 37.96 0ATOM 1179 06 SER A 162 -26.431 -13.052 -15. 890 1. 00 37.96 0
ATOM 1180 C SER A 162 -24.257 -11.451 -15. 065 1. 00 35.09 CATOM 1180 C SER A 162 -24.257 -11.451 -15. 065 1. 00 35.09 C
ATOM 1181 0 SER A 162 -23.401 -12.316 -14.888 1. 00 34.87 0ATOM 1181 0 SER A 162 -23.401 -12.316 -14.888 1.00 34.87 0
ATOM 1182 N lLE A 163 -24.683 -10.651 -14. 094 1. 00. 33.81 NATOM 1182 N lLE A 163 -24.683 -10.651 -14. 094 1. 00. 33.81 N
ATOM 1183 CA ILE A 163 -24.197 -10.764 -12. 727 1. ,00 31.52 CATOM 1183 CA ILE A 163 -24.197 -10.764 -12. 727 1., 00 31.52 C
ATOM 1184 CB ILE A 163 -23.471 -9.492 - 12. 283 1. 00 30.51 CATOM 1184 CB ILE A 163 -23.471 -9.492-12. 283 1. 00 30.51 C
ATOM 1185 CG2 ILE A 163 -23.083 -9.596 -10. 827 1. ,00 28.63 CATOM 1185 CG2 ILE A 163 -23.083 -9.596 -10. 827 1., 00 28.63 C
ATOM 1186 CG1 ILE A 163 -22.240 -9.266 -13. 144 1. ,00 29.44 CATOM 1186 CG1 ILE A 163 -22.240 -9.266 -13. 144 1., 00 29.44 C
ATOM 1187 CD1 ILE A 163 -21 · 492 -8.012 - 12. 775 1. ,00 31.52 CATOM 1187 CD1 ILE A 163 -21 492 -8.012-12. 775 1., 00 31.52 C
ATOM 1188 C ILE A 163 -25.368 -10.968 - 11. 784 1. ,00 32.58 CATOM 1188 C ILE A 163 -25.368 -10.968-11. 784 1., 00 32.58 C
ATOM 1189 0 ILE A 163 -26.402 -10.311 -11. 923 1. .00 34.09 0ATOM 1189 0 ILE A 163 -26.402 -10.311 -11. 923 1. .00 34.09 0
ATOM 1190 N LYS A 164 -25.197 -11.870 -10. 822 1. .00 30.03 . NATOM 1190 N LYS A 164 -25.197 -11.870 -10. 822 1. .00 30.03. N
ATOM 1191 CA LYS A 164 -26.226 -12.142 -9. 830 1. .00 26.84 CATOM 1191 CA LYS A 164 -26.226 -12.142 -9. 830 1. .00 26.84 C
ATOM 1192 CB LYS A 164 -26.967 -13.429 -10. 191 1. .00 27.97 CATOM 1192 CB LYS A 164 -26.967 -13.429 -10. 191 1. .00 27.97 C
ATOM 1193 C6 LYS A 164 - 27.535 -13.428 - 11. 605 1, .00 27.70 CATOM 1193 C6 LYS A 164-27.535 -13.428-11. 605 1, .00 27.70 C
ATOM 1194 CD LYS A 164 -28.652 -14.453 -11. 757 1, .00 25.45 CATOM 1194 CD LYS A 164 -28.652 -14.453 -11. 757 1, .00 25.45 C
ATOM 1195 CE LYS A 164 -29.310 -14.346 -13. , 129 1, .00 25.87 CATOM 1195 CE LYS A 164 -29.310 -14.346 -13., 129 1, .00 25.87 C
ATOM 1196 NZ LYS A 164 - 30.420 -15.312 - 13. 258 1, .00 22.67 NATOM 1196 NZ LYS A 164-30.420 -15.312-13. 258 1, .00 22.67 N
ATOM 1197 C LYS A 164 -25.622 -12.266 -8. ,437 1 .00 24.90 CATOM 1197 C LYS A 164 -25.622 -12.266 -8., 437 1 .00 24.90 C
ATOM 1198 0 LYS A 164 -24.462 - 12.630 -8. 287 1. .00 26.64 0ATOM 1198 0 LYS A 164 -24.462-12.630 -8. 287 1. .00 26.64 0
ATOM 1199 N VAL A 165 -26.414 -11.959 -7. ,415 1 .00 25.05 N ATOM 1200 CA VAL A 165 - 25.939 - 12.007 -6.034 1.00 21.66 CATOM 1199 N VAL A 165 -26.414 -11.959 -7., 415 1 .00 25.05 N ATOM 1200 CA VAL A 165-25.939-12.007 -6.034 1.00 21.66 C
ATOM 1201 CB VAL A 165 -26.062 -10.644 -5.356 1. 00 19.72 CATOM 1201 CB VAL A 165 -26.062 -10.644 -5.356 1. 00 19.72 C
ATOM 1202 CGI VAL A 165 -25.602 -10.747 -3.917 1. 00 17.15 CATOM 1202 CGI VAL A 165 -25.602 -10.747 -3.917 1.00 17.15 C
ATOM 1203 CG2 VAL A 165 -25.251 -9.605 -6.123 1. 00 18.97 CATOM 1203 CG2 VAL A 165 -25.251 -9.605 -6.123 1.00 18.97 C
ATOM 1204 C VAL A 165 -26.737 -12.996 -5.209 1. 00 22.47 CATOM 1204 C VAL A 165 -26.737 -12.996 -5.209 1.00 22.47 C
ATOM 1205 0 VAL A 165 - 27.960 -12.966 - 5.218 1. 00 24.82 0ATOM 1205 0 VAL A 165-27.960 -12.966-5.218 1. 00 24.82 0
ATOM 1206 N LEU A 166 -26.050 -13.871 -4.488 1. 00 21.89 NATOM 1206 N LEU A 166 -26.050 -13.871 -4.488 1. 00 21.89 N
ATOM 1207 CA LEU A 166 -26.735 -14.751 -3.560 1. 00 22.72 CATOM 1207 CA LEU A 166 -26.735 -14.751 -3.560 1.00 22.72 C
ATOM 1208 CB LEU A 166 -26.432 -16.218 -3.871 1. 00 21.63 CATOM 1208 CB LEU A 166 -26.432 -16.218 -3.871 1.00 21.63 C
ATOM 1209 CG LEU A 166 -26.441 -16.653 -5.341 1. 00 23.84 CATOM 1209 CG LEU A 166 -26.441 -16.653 -5.341 1. 00 23.84 C
ATOM 1210 CD1 LEU A 166 - 26.266 -18.173 -5.423 1. 00 22.39 CATOM 1210 CD1 LEU A 166-26.266 -18.173 -5.423 1. 00 22.39 C
ATOM 1211 CD2 LEU A 166 -27.731 -16.233 -6.004 1. 00 20.56 CATOM 1211 CD2 LEU A 166 -27.731 -16.233 -6.004 1.00 20.56 C
ATOM 1212 G LEU A 166 -26.290 - 14.430 -2.143 1. 00 22.41 CATOM 1212 G LEU A 166 -26.290-14.430 -2.143 1.00 22.41 C
ATOM 1213 0 LEU A 166 -25.114 -14.568 - 1.803 1. 00 22.86 0ATOM 1213 0 LEU A 166 -25.114 -14.568-1.803 1.00 22.86 0
ATOM 1214 N VAL A 167 -27.242 -14.007 -1.325 1. .00 20.56 NATOM 1214 N VAL A 167 -27.242 -14.007 -1.325 1. .00 20.56 N
ATOM 1215 CA VAL A 167 -27.013 -13.841 0.096 1. ,00 19.32 CATOM 1215 CA VAL A 167 -27.013 -13.841 0.096 1., 00 19.32 C
ATOM 1216 CB VAL A 167 -27.123 -12.355 0.485 1. 00 18.22 CATOM 1216 CB VAL A 167 -27.123 -12.355 0.485 1. 00 18.22 C
ATOM 1217 C61 VAL A 167 -26.156 -11.536 -0.357 1. ,00 17.52 CATOM 1217 C61 VAL A 167 -26.156 -11.536 -0.357 1., 00 17.52 C
ATOM 1218 CG2 VAL A 167 -28.544 -11 · 869 0.297 1. ,00 14.13 CATOM 1218 CG2 VAL A 167 -28.544 -11 869 0.297 1., 00 14.13 C
ATOM 1219 C VAL A 167 -28.004 -14.664 0.929 1. ,00 19.43 CATOM 1219 C VAL A 167 -28.004 -14.664 0.929 1., 00 19.43 C
ATOM 1220 0 VAL A 167 -29.050 -15.084 0.433 1. .00 20.23 0ATOM 1220 0 VAL A 167 -29.050 -15.084 0.433 1. .00 20.23 0
ATOM 1221 N LEU A 168 - 27.660 -14.882 2.194 1. ,00 20.28 NATOM 1221 N LEU A 168-27.660 -14.882 2.194 1., 00 20.28 N
ATOM 1222 CA LEU A 168 -28.527 -15.569 3.150 1. ,00 20.41 CATOM 1222 CA LEU A 168 -28.527 -15.569 3.150 1., 00 20.41 C
ATOM 1223 CB LEU A 168 - 27.691 -16.118 4.309 1, .00 22.18 CATOM 1223 CB LEU A 168-27.691 -16.118 4.309 1, .00 22.18 C
ATOM 1224 GG LEU A 168 - 27.200 -17.567 4.236 1, .00 23.76 CATOM 1224 GG LEU A 168-27.200 -17.567 4.236 1, .00 23.76 C
ATOM 1225 CD1 LEU A 168 - 27.213 -18.049 2.805 1, .00 23.65 CATOM 1225 CD1 LEU A 168-27.213 -18.049 2.805 1, .00 23.65 C
ATOM 1226 CD2 LEU A 168 -25.814一 17.662 4.841 1, .00 20.97 CATOM 1226 CD2 LEU A 168 -25.814 1 17.662 4.841 1, .00 20.97 C
ATOM 1227 C LEU A 168 - 29.591 -14.637 3.715 1, .00 21.32 CATOM 1227 C LEU A 168-29.591 -14.637 3.715 1, .00 21.32 C
ATOM 1228 0 LEU A 168 -30.776 -14.973 3.744 1 .00 23.45 0ATOM 1228 0 LEU A 168 -30.776 -14.973 3.744 1 .00 23.45 0
ATOM 1229 N VAL A 169 -29.164 -13.471 4.189 1 .00 21.58 NATOM 1229 N VAL A 169 -29.164 -13.471 4.189 1 .00 21.58 N
ATOM 1230 CA VAL A 169 -30.092 -12.507 4.760 1 .00 21.62 CATOM 1230 CA VAL A 169 -30.092 -12.507 4.760 1 .00 21.62 C
ATOM 1231 CB VAL A 169 -30.108 -12.581 6.307 1 • 00 20.33 CATOM 1231 CB VAL A 169 -30.108 -12.581 6.307 1 • 00 20.33 C
ATOM 1232 CG1 VAL A 169 - 30.263 -14.029 6.748 1 .00 16.36 CATOM 1232 CG1 VAL A 169-30.263 -14.029 6.748 1.00 16.36 C
ATOM 1233 CG2 VAL A 169 - 28.855 - 11.973 6.880 1 • 00 20.14 CATOM 1233 CG2 VAL A 169-28.855-11.973 6.880 1 • 00 20.14 C
ATOM 1234 C VAL A 169 -29.730 -11.095 4.328 1 • 00 23.02 CATOM 1234 C VAL A 169 -29.730 -11.095 4.328 1 • 00 23.02 C
ATOM 1235 0 VAL A 169 -28.553 -10.735 4.241 1 .00 25.22 0 ATOM 1236 N ALA A 170 -30.759 -10.305 4.041 1.00 22.64 ΝATOM 1235 0 VAL A 169 -28.553 -10.735 4.241 1 .00 25.22 0 ATOM 1236 N ALA A 170 -30.759 -10.305 4.041 1.00 22.64 Ν
ATOM 1237 CA ALA A 170 -30.583 -8.979 3.484 1. 00 21. 59 CATOM 1237 CA ALA A 170 -30.583 -8.979 3.484 1. 00 21. 59 C
ATOM 1238 GB ALA A 170 -30.907 -8.991 1.999 1. 00 18.43 CATOM 1238 GB ALA A 170 -30.907 -8.991 1.999 1.00 18.43 C
ATOM 1239 C ALA A 170 -31.487 -7.999 4.209 1. 00 22.54 CATOM 1239 C ALA A 170 -31.487 -7.999 4.209 1. 00 22.54 C
ATOM 240 0 ALA A 170 -32.621 -8.322 4.562 1. 00 21. 90 0ATOM 240 0 ALA A 170 -32.621 -8.322 4.562 1. 00 21. 90 0
ATOM 1241 N ALA A 171 -30.966 -6.802 4.442 1. 00 23.77 ΝATOM 1241 N ALA A 171 -30.966 -6.802 4.442 1. 00 23.77 Ν
ATOM 1242 CA ALA A 171 - 31.770 -5.711 4.960 1. 00 23.84 CATOM 1242 CA ALA A 171-31.770 -5.711 4.960 1. 00 23.84 C
ATOM 1243 CB ALA A 171 -30.926 -4.803 5.856 1. 00 21. 90 CATOM 1243 CB ALA A 171 -30.926 -4.803 5.856 1. 00 21. 90 C
ATOM 1244 C ALA A 171 - 32.268 -4.937 3.759 1. 00 25.22 CATOM 1244 C ALA A 171-32.268 -4.937 3.759 1. 00 25.22 C
ATOM 1245 0 ALA A 171 -4.912 2.711 1. 00 23.35 0ATOM 1245 0 ALA A 171 -4.912 2.711 1. 00 23.35 0
ATOM 1246 N PRO A 172 -33.436 -4.290 3.899 1. 00 26.67 ΝATOM 1246 N PRO A 172 -33.436 -4.290 3.899 1. 00 26.67 Ν
ATOM 1247 CD PRO A 172 -34.299 - 4.330 5.093 1. 00 26.50 CATOM 1247 CD PRO A 172 -34.299-4.330 5.093 1.00 26.50 C
ATOM 1248 CA PRO A 172 - 34.021 -3.479 2.829 1. 00 26. 45 CATOM 1248 CA PRO A 172-34.021 -3.479 2.829 1. 00 26. 45 C
ATOM 1249 CB PRO A 172 -35.311 -2.935 3.449 1. 00 27. 81 CATOM 1249 CB PRO A 172 -35.311 -2.935 3.449 1. 00 27. 81 C
ATOM 1250 CG PRO A 172 -35.629 -3.889 4.554 1. 00 29. 03 CATOM 1250 CG PRO A 172 -35.629 -3.889 4.554 1. 00 29. 03 C
ATOM 1251 C PRO A 172 -33.078 -2.363 2.404 1. ,00 26. 88 CATOM 1251 C PRO A 172 -33.078 -2.363 2.404 1., 00 26. 88 C
ATOM 1252 0 PRO A 172 -32.993 -2.030 1.219 1. .00 26. 06 0ATOM 1252 0 PRO A 172 -32.993 -2.030 1.219 1. .00 26. 06 0
ATOM 1253 N GLU A 173 -32.365 - 1 · 789 3.371 1. ,00 27. 93 ΝATOM 1253 N GLU A 173 -32.365-1 789 3.371 1., 00 27. 93 Ν
ATOM 1254 CA 6LU A 173 -31.449 - 0.690 3.079 1. ,00 30. 53 CATOM 1254 CA 6LU A 173 -31.449-0.690 3.079 1., 00 30. 53 C
ATOM 1255 CB GLU A 173 -30.771 -0.198 4.357 1. ,00 35. 01 CATOM 1255 CB GLU A 173 -30.771 -0.198 4.357 1., 00 35. 01 C
ATOM 1256 CG GLU A 173 -31.714 0.388 5.393 1. .00 39. 60 CATOM 1256 CG GLU A 173 -31.714 0.388 5.393 1. .00 39. 60 C
ATOM 1257 CD GLU A 173 -32.309 -0.672 6.290 1. ,00 42. 64 CATOM 1257 CD GLU A 173 -32.309 -0.672 6.290 1., 00 42. 64 C
ATOM 1258 0E1 GLU A 173 -32.678 -1.748 5.771 1. .00 44. 53 0ATOM 1258 0E1 GLU A 173 -32.678 -1.748 5.771 1. .00 44. 53 0
ATOM 1259 0E2 GLU A 173 -32.404 -0.431 7.512 1. .00 44. 74 0ATOM 1259 0E2 GLU A 173 -32.404 -0.431 7.512 1. .00 44. 74 0
ATOM 1260 C GLU A 173 - 30.375 - 1.130 2.084 1. .00 31. 56 CATOM 1260 C GLU A 173-30.375-1.130 2.084 1. .00 31. 56 C
ATOM 1261 0 GLU A 173 -30.013 -0.385 1, .00 30. 79 0ATOM 1261 0 GLU A 173 -30.013 -0.385 1, .00 30. 79 0
ATOM 1262 N GLY A 174 -29.871 -2.348 2.277 1, .00 30. 57 ΝATOM 1262 N GLY A 174 -29.871 -2.348 2.277 1, .00 30. 57 Ν
ATOM 1263 CA GLY A 174 -28.857 -2.873 1.386 1, .00 28. 75 CATOM 1263 CA GLY A 174 -28.857 -2.873 1.386 1, .00 28. 75 C
ATOM 1264 C GLY A 174 -29.442 -3.102 0.010 1, .00 26. 81 CATOM 1264 C GLY A 174 -29.442 -3.102 0.010 1, .00 26. 81 C
ATOM 1265 0 GLY A 174 - 28.828 -2.758 -0.995 1, .00 28. 91 0ATOM 1265 0 GLY A 174-28.828 -2.758 -0.995 1, .00 28. 91 0
ATOM 1266 N ILE A 175 - 30.644 -3.666 -0.032 1, .00 25. 30 ΝATOM 1266 N ILE A 175-30.644 -3.666 -0.032 1, .00 25. 30 Ν
ATOM 1267 CA ILE A 175 -31.307 -3.960 - 1.295 1, .00 24. 34 CATOM 1267 CA ILE A 175 -31.307 -3.960-1.295 1, .00 24. 34 C
ATOM 1268 CB ILE A 175 - 32.629 -4.696 -1.053 1 .00 23. 85 CATOM 1268 CB ILE A 175-32.629 -4.696 -1.053 1 .00 23. 85 C
ATOM 1269 CG2 ILE A 175 -33.351 -4.935 -2.371 1 .00 25. 41 CATOM 1269 CG2 ILE A 175 -33.351 -4.935 -2.371 1 .00 25. 41 C
ATOM 1270 CG1 ILE A 175 -32.346 - 6.018 -0.338 1, .00 22. 73 CATOM 1270 CG1 ILE A 175 -32.346-6.018 -0.338 1, .00 22. 73 C
ATOM 1271 CD1 ILE A 175 -33.584 一 6.792 0.014 1 .00 22. 74 C ATOM 1272 C ILE A 175 -31.567 -2.700 -2.122 1.00 24.93 CATOM 1271 CD1 ILE A 175 -33.584 1 6.792 0.014 1 .00 22. 74 C ATOM 1272 C ILE A 175 -31.567 -2.700 -2.122 1.00 24.93 C
ATOM 1273 0 ILE A 175 -31. 303 -2.678 -3.328 1. 00 24.99 0ATOM 1273 0 ILE A 175 -31. 303 -2.678 -3.328 1.00 24.99 0
ATOM 1274 N ALA A 176 -32. 063 -1■ 650 -1.471 1. 00 25.06 NATOM 1274 N ALA A 176 -32. 063 -1 650 -1.471 1. 00 25.06 N
ATOM 1275 CA ALA A 176 一 32. 318 - 0.378 -2.146 1. 00 25.18 CATOM 1275 CA ALA A 176 One 32. 318-0.378 -2.146 1. 00 25.18 C
ATOM 1276 GB ALA A 176 -33. 035 0.583 -1.206 1. 00 22.69 CATOM 1276 GB ALA A 176 -33. 035 0.583 -1.206 1.00 22.69 C
ATOM 1277 C ALA A 176 -31. 016 0.248 -2.636 1. 00 26.90 CATOM 1277 C ALA A 176 -31. 016 0.248 -2.636 1. 00 26.90 C
ATOM 1278 0 ALA A 176 -30. 977 0.874 -3.696 1. 00 28.25 0ATOM 1278 0 ALA A 176 -30. 977 0.874 -3.696 1. 00 28.25 0
ATOM 1279 N ALA A 177 -29. 944 0.080 - 1.870 1. 00 27.96 NATOM 1279 N ALA A 177 -29. 944 0.080-1.870 1. 00 27.96 N
ATOM 1280 CA ALA A 177 -28. 647 0.575 -2.312 1. 00 28.69 CATOM 1280 CA ALA A 177 -28. 647 0.575 -2.312 1. 00 28.69 C
ATOM 1281 CB ALA A 177 - 27. 639 0.493 -1.177 1. 00 24.66 CATOM 1281 CB ALA A 177-27. 639 0.493 -1.177 1. 00 24.66 C
ATOM 1282 C ALA A 177 -28. 156 -0.217 -3.530 1. 00 30.69 CATOM 1282 C ALA A 177 -28. 156 -0.217 -3.530 1. 00 30.69 C
ATOM 1283 .0 ALA A 177 -27. 496 0.329 -4.413 1. 00 32.35 0ATOM 1283 .0 ALA A 177 -27. 496 0.329 -4.413 1. 00 32.35 0
ATOM 1284 N LEU A 178 -28. 495 -1.499 - 3.585 1. 00 31.04 NATOM 1284 N LEU A 178 -28. 495 -1.499-3.585 1. 00 31.04 N
ATOM 1285 CA LEU A 178 -28. 103 - 2.332 -4.714 1. 00 31.49 CATOM 1285 CA LEU A 178 -28. 103-2.332 -4.714 1. 00 31.49 C
ATOM 1286 CB LEU A 178 -28, 271 -3.817 -4.364 1. .00 29.81 CATOM 1286 CB LEU A 178 -28, 271 -3.817 -4.364 1. .00 29.81 C
ATOM 1287 CG LEU A 178 -28. 277 -4.788 -5.547 1. 00 28.01 CATOM 1287 CG LEU A 178 -28. 277 -4.788 -5.547 1. 00 28.01 C
ATOM 1288 CD1 LEU A 178 -26. 984 - 4.657 - 6.336 1. , 00 28.72 CATOM 1288 CD1 LEU A 178 -26. 984-4.657-6.336 1., 00 28.72 C
ATOM 1289 CD2 LEU A 178 -28. 454 -6.209 -5.034 1. ,00 28.99 CATOM 1289 CD2 LEU A 178 -28. 454 -6.209 -5.034 1., 00 28.99 C
ATOM 1290 C LEU A 178 -28. 938 -1.999 - 5.940 1. ,00 31.62 CATOM 1290 C LEU A 178 -28. 938 -1.999-5.940 1., 00 31.62 C
ATOM 1291 0 LEU A 178 -28. 405 -1.803 - 7.028 1. , 00 30.58 0ATOM 1291 0 LEU A 178 -28. 405 -1.803-7.028 1., 00 30.58 0
ATOM 1292 N 6LU A 179 -30. 253 -1.940 -5.766 1. .00 34.04 NATOM 1292 N 6LU A 179 -30. 253 -1.940 -5.766 1. .00 34.04 N
ATOM 1293 CA GLU A 179 -31. 140 - 1.608 - 6.876 1. .00 34.54 CATOM 1293 CA GLU A 179 -31. 140-1.608-6.876 1. .00 34.54 C
ATOM 1294 CB GLU A 179 -32. 594 -1.627 -6.419 1. , 00 33.67 CATOM 1294 CB GLU A 179 -32. 594 -1.627 -6.419 1., 00 33.67 C
ATOM 1295 CG GLU A 179 -33. 126 -3.020 -6.217 1. .00 37.89 CATOM 1295 CG GLU A 179 -33. 126 -3.020 -6.217 1. .00 37.89 C
ATOM 1296 CD GLU A 179 -34. 548 -3.028 -5.739 1. .00 38.40 CATOM 1296 CD GLU A 179 -34. 548 -3.028 -5.739 1. .00 38.40 C
ATOM 1297 0E1 GLU A 179 -34. 784 -2.657 -4.570 1, .00 43.36 0ATOM 1297 0E1 GLU A 179 -34. 784 -2.657 -4.570 1, .00 43.36 0
ATOM 1298 0E2 GLU A 179 -35. 433 - 3.403 -6.532 1, ■ 00 43.29 .0ATOM 1298 0E2 GLU A 179 -35. 433-3.403 -6.532 1, ■ 00 43.29 .0
ATOM 1299 C GLU A 179 -30. 810 -0.250 -7.482 1, .00 33.37 CATOM 1299 C GLU A 179 -30. 810 -0.250 -7.482 1, .00 33.37 C
ATOM 1300 0 GLU A 179' -31. 019 -0.035 -8.673 1, .00 34.53 0ATOM 1300 0 GLU A 179 '-31. 019 -0.035 -8.673 1, .00 34.53 0
ATOM 1301 N LYS A 180 - 30. 284 0.656 -6.666 1 .00 32.26 NATOM 1301 N LYS A 180-30. 284 0.656 -6.666 1 .00 32.26 N
ATOM 1302 CA LYS A 180 -29. 939 1.991 -7.144 1 .00 32.92 CATOM 1302 CA LYS A 180 -29. 939 1.991 -7.144 1 .00 32.92 C
ATOM 1303 CB LYS A 180 -29. 802 2.960 -5.967 1 .00 31.14 CATOM 1303 CB LYS A 180 -29. 802 2.960 -5.967 1 .00 31.14 C
ATOM 1304 C6 LYS A 180 -29. 918 4.413 -6.372 1 .00 34.28 CATOM 1304 C6 LYS A 180 -29. 918 4.413 -6.372 1 .00 34.28 C
ATOM 1305 CD LYS A 180 -29. 518 5.365 -5.257 1 .00 35.26 CATOM 1305 CD LYS A 180 -29. 518 5.365 -5.257 1 .00 35.26 C
ATOM 1306 CE LYS A 180 - 29. ,726 6.815 -5.697 1 .00 38.87 CATOM 1306 CE LYS A 180-29., 726 6.815 -5.697 1 .00 38.87 C
ATOM 1307 NZ LYS A 180 -29. 090 7.808 -4.780 1 .00 39.80 N ATOM 1308 C LYS A 180 -28.637 1.976 -7.948 1.00 33.30 CATOM 1307 NZ LYS A 180 -29. 090 7.808 -4.780 1 .00 39.80 N ATOM 1308 C LYS A 180 -28.637 1.976 -7.948 1.00 33.30 C
ATOM 1309 0 LYS A 180 -28.574 2.522 -9. 050 1. 00 32.93 0ATOM 1309 0 LYS A 180 -28.574 2.522 -9. 050 1. 00 32.93 0
ATOM 1310 N ALA A 181 -27.606 1.344 -7. 393 1. 00 32.49 ΝATOM 1310 N ALA A 181 -27.606 1.344 -7. 393 1. 00 32.49 Ν
ATOM 1311 CA ALA A 181 -26.280 1.351 - 8. 002 1. 00 32.05 CATOM 1311 CA ALA A 181 -26.280 1.351-8. 002 1.00 32.05 C
ATOM 1312 CB ALA A 181 -25.251 0.875 - 7. 001 1. 00 32.50 CATOM 1312 CB ALA A 181 -25.251 0.875-7. 001 1.00 32.50 C
ATOM 1313 C ALA A 181 -26.236 0.470 -9. 234 1. 00 33.14 CATOM 1313 C ALA A 181 -26.236 0.470 -9. 234 1. 00 33.14 C
ATOM 1314 0 ALA A 181 - 25.536 0.769 -10. 201 1. 00 33.38 0ATOM 1314 0 ALA A 181-25.536 0.769 -10. 201 1. 00 33.38 0
ATOM 1315 N HIS A 182 - 26.990 -0.622 -9. 188 1. 00 33.09 Ν ATOM 1315 N HIS A 182-26.990 -0.622 -9. 188 1. 00 33.09 Ν
I I
ATOM 1316 CA HIS A 182 -26.893 -1.664 -10. 197 1. 00 32.82 CATOM 1316 CA HIS A 182 -26.893 -1.664 -10. 197 1. 00 32.82 C
O O
ATOM 1317 CB HIS A 182 -25.907 -2.742 - 9. 733 1. 00 32.08 CATOM 1317 CB HIS A 182 -25.907 -2.742-9. 733 1. 00 32.08 C
ATOM 1318 C6 HIS A 182 -24.500 - 2.254 - 9. 632 1. 00 29.91 CATOM 1318 C6 HIS A 182 -24.500-2.254-9. 632 1.00 29.91 C
ATOM 1319 CD2 HIS A 182 -23.724 -1.981 - 8. 558 1. 00 32.84 CATOM 1319 CD2 HIS A 182 -23.724 -1.981-8. 558 1.00 32.84 C
ATOM 1320 ND1 HIS A 182 - 23.750 - 1.927 -10. 741 1. 00 31.02 .ATOM 1320 ND1 HIS A 182-23.750-1.927 -10. 741 1. 00 31.02.
ATOM 1321 CE1 HIS A 182 -22.573 -1 · 469 -10. 354 1. 00 31.57 CATOM 1321 CE1 HIS A 182 -22.573 -1 469 -10. 354 1. 00 31.57 C
ATOM 1322 NE2 HIS A 182 - 22.532 -1.490 -9. 034 1. 00 32.44 ΝATOM 1322 NE2 HIS A 182-22.532 -1.490 -9. 034 1. 00 32.44 Ν
ATOM 1323 C HIS A 182 -28.255 - 2.289 -10. 451 1. 00 32.43 CATOM 1323 C HIS A 182 -28.255-2.289 -10. 451 1. 00 32.43 C
ATOM 1324 0 HIS A 182 -28.518 -3.414 -10. 036 1. 00 31.73 0ATOM 1324 0 HIS A 182 -28.518 -3.414 -10. 036 1. 00 31.73 0
ATOM 1325 N PRO A 183 - 29.136 -1.559 -11. 147 1. 00 32.86 ΝATOM 1325 N PRO A 183-29.136 -1.559 -11. 147 1. 00 32.86 Ν
ATOM 1326 CD PRO A 183 -28.890 -0.218 - 11. 713 1. 00 .31.48 CATOM 1326 CD PRO A 183 -28.890 -0.218-11. 713 1. 00 .31.48 C
ATOM 1327 CA PRO A 183 - 30.495 -2.040 -11. 427 1. 00 32.77 CATOM 1327 CA PRO A 183-30.495 -2.040 -11. 427 1. 00 32.77 C
ATOM 1328 CB PRO A 183 -0.841 -12. 102 1. ,00 31.39 CATOM 1328 CB PRO A 183 -0.841 -12. 102 1., 00 31.39 C
ATOM 1329 C6 PRO A 183 - 30.058 - 0.012 -12. 634 1. ,00 30.78 CATOM 1329 C6 PRO A 183-30.058-0.012 -12. 634 1., 00 30.78 C
ATOM 1330 C PRO A 183 -30.554 -3.301 -12.290 1. ,00 33.13 CATOM 1330 C PRO A 183 -30.554 -3.301 -12.290 1., 00 33.13 C
ATOM 1331 0 PRO A 183 - 3.939 - 12. 384 1. ,00 34.82 0ATOM 1331 0 PRO A 183-3.939-12. 384 1., 00 34.82 0
ATOM 1332 N ASP A 184 -29.441 - 3.673 -12. 915 1. .00 33.08 ΝATOM 1332 N ASP A 184 -29.441-3.673 -12. 915 1. .00 33.08 Ν
ATOM 1333 CA ASP A 184 -29.448 -4.858 -13. 777 1. .00 34.68 CATOM 1333 CA ASP A 184 -29.448 -4.858 -13. 777 1. .00 34.68 C
ATOM 1334 CB ASP A 184 -28.585 -4.611 -15. 021 1, .00 33.49 CATOM 1334 CB ASP A 184 -28.585 -4.611 -15. 021 1, .00 33.49 C
ATOM 1335 CG ASP A 184 -27.118 -4.423 - 14. 693 1. .00 32.72 CATOM 1335 CG ASP A 184 -27.118 -4.423-14. 693 1. .00 32.72 C
ATOM 1336 0D1 ASP A 184 -26.281 - 4.901 -15. 481 1, .00 38.18 0ATOM 1336 0D1 ASP A 184 -26.281-4.901 -15. 481 1, .00 38.18 0
ATOM 1337 0D2 ASP A 184 -26.794 - 3.800 - 13. 665 1, .00 30.22 QATOM 1337 0D2 ASP A 184 -26.794-3.800-13. 665 1, .00 30.22 Q
ATOM 1338 C ASP A 184 -29.002 -6.155 -13. ,083 1, .00 34.89 CATOM 1338 C ASP A 184 -29.002 -6.155 -13., 083 1, .00 34.89 C
ATOM 1339 0 ASP A 184 -28.869 -7.194 -13. ,723 1, .00 34.20 0ATOM 1339 0 ASP A 184 -28.869 -7.194 -13., 723 1, .00 34.20 0
ATOM 1340 N VAL A 185 -28.783 - 6.087 -11. ,774 1 • 00 35.17 ΝATOM 1340 N VAL A 185 -28.783-6.087 -11., 774 1 • 00 35.17 Ν
ATOM 1341 CA VAL A 185 -28.246 -7.212 -11. ,017 1 .00 32.86 CATOM 1341 CA VAL A 185 -28.246 -7.212 -11., 017 1 .00 32.86 C
ATOM 1342 CB VAL A 185 -27.126 -6.745 -10. .070 1 ■ 00 33.16 CATOM 1342 CB VAL A 185 -27.126 -6.745 -10..070 1 ■ 00 33.16 C
ATOM 1343 CG1 VAL A 185 -26.612 一 7.912 —9. ,254 1 .00 31.82 C ATOM 1344 CG2 VAL A 185 -26.004 -6.111 -10.875 1.00 32.32 CATOM 1343 CG1 VAL A 185 -26.612 One 7.912 —9., 254 1 .00 31.82 C ATOM 1344 CG2 VAL A 185 -26.004 -6.111 -10.875 1.00 32.32 C
ATOM 1345 C VAL A 185 - 29.325 -7.881 -10.181 1. 00 33.34 CATOM 1345 C VAL A 185-29.325 -7.881 -10.181 1. 00 33.34 C
ATOM 1346 0 VAL A 185 -29.858 -7.278 -9.248 1. 00 35.49 0ATOM 1346 0 VAL A 185 -29.858 -7.278 -9.248 1.00 35.49 0
ATOM 1347 N GLU A 186 -29.642 -9.131 -10.506 1. 00 31.37 NATOM 1347 N GLU A 186 -29.642 -9.131 -10.506 1. 00 31.37 N
ATOM 1348 CA GLU A 186 - 30.652 -9.859 -9.754 1. 00 29.33 CATOM 1348 CA GLU A 186-30.652 -9.859 -9.754 1. 00 29.33 C
ATOM 1349 CB GLU A 186 -31.068 - 10.494 1. 00 31.21 CATOM 1349 CB GLU A 186 -31.068-10.494 1. 00 31.21 C
ATOM 1350 C6 GLU A 186 -31.719 -10.892 - 11.842 1. 00 34.73 CATOM 1350 C6 GLU A 186 -31.719 -10.892-11.842 1.00 34.73 C
ATOM 1351 CD GLU A 186 -32.309 - 12.158 -12.447 1. 00 39.20 CATOM 1351 CD GLU A 186 -32.309-12.158 -12.447 1. 00 39.20 C
ATOM 1352 0E1 GLU A 186 -32.013 -13.266 -11.940 1. 00 39.80 0ATOM 1352 0E1 GLU A 186 -32.013 -13.266 -11.940 1.00 39.80 0
ATOM 1353 0E2 GLU A 186 -33.072 -12.043 -13.433 1. 00 40.48 0ATOM 1353 0E2 GLU A 186 -33.072 -12.043 -13.433 1.00 40.48 0
ATOM 1354 C GLU A 186 - 30.118 -10.228 -8.382 1. 00 28.21 CATOM 1354 C GLU A 186-30.118 -10.228 -8.382 1. 00 28.21 C
ATQM 1355 0 GLU A 186 . -28.942 -10.565 -8.231 1. 00 29.21 0ATQM 1355 0 GLU A 186 .-28.942 -10.565 -8.231 1. 00 29.21 0
ATOM 1356 N LEU A 187 - 30.984 -10.158 - 7.380 1. 00 26.92 . NATOM 1356 N LEU A 187-30.984 -10.158-7.380 1. 00 26.92 .N
ATOM 1357 CA LEU A 187 -30.638 - 10.649 -6.056 1. 00 24.70 CATOM 1357 CA LEU A 187 -30.638-10.649 -6.056 1.00 24.70 C
ATOM 1358 CB LEU A 187 -30.905 -9.576 - 5.005 1. 00 23.27 CATOM 1358 CB LEU A 187 -30.905 -9.576-5.005 1.00 23.27 C
ATOM 1359 CG LEU A 187 -30.508 -10.009 -3.594 1. 00 23.47 CATOM 1359 CG LEU A 187 -30.508 -10.009 -3.594 1.00 23.47 C
ATOM 1360 CD1 LEU A 187 -28.988 -9.994 -3.496 1. 00 25.24 CATOM 1360 CD1 LEU A 187 -28.988 -9.994 -3.496 1. 00 25.24 C
ATOM 1361 CD2 LEU A 187 -31.114 -9.085 -2.560 1. 00 23.56 GATOM 1361 CD2 LEU A 187 -31.114 -9.085 -2.560 1.00 23.56 G
ATOM 1362 C LEU A 187 -31.446 -5.711 1. 00 24.15 CATOM 1362 C LEU A 187 -31.446 -5.711 1. 00 24.15 C
ATOM 1363 0 LEU A 187 -32.636 -11.988 -6.009 1. , 00 24.94 0ATOM 1363 0 LEU A 187 -32.636 -11.988 -6.009 1., 00 24.94 0
ATOM 1364 N TYR A 188 -30.800 - 12.871 -5.080 1. 00 21.97 ATOM 1364 N TYR A 188 -30.800-12.871 -5.080 1.00 21.97
ATOM 1365 CA TYR A 188 - 31.523 - 13.989 -4.486 1. ,00 24.19 C ATOM 1365 CA TYR A 188-31.523-13.989 -4.486 1., 00 24.19 C
ATOM 1366 CB TYR A 188 -31.235 -15.275 -5.255 1. ,00 22.14 CATOM 1366 CB TYR A 188 -31.235 -15.275 -5.255 1., 00 22.14 C
ATOM 1367 CG TYR A 188 - 31.825 -15.277 -6.652 1. , 00 24.42 CATOM 1367 CG TYR A 188-31.825 -15.277 -6.652 1., 00 24.42 C
ATOM • 1368 CD1 TYR A 188 -31.169 -14.655 -7.707 1. , 00 23.64 CATOM • 1368 CD1 TYR A 188 -31.169 -14.655 -7.707 1., 00 23.64 C
ATOM 1369 GE1 TYR A 188 -31.707 -14.661 -8.986 1. .00 24.42 CATOM 1369 GE1 TYR A 188 -31.707 -14.661 -8.986 1. .00 24.42 C
ATOM 1370 CD2 TYR A 188 -33.039 -15.907 -6.914 1. .00 23.69 . CATOM 1370 CD2 TYR A 188 -33.039 -15.907 -6.914 1. .00 23.69. C
ATOM 1371 CE2 TYR A 188 -33.581 -15.921 - 8.186 1, .00 23.04 GATOM 1371 CE2 TYR A 188 -33.581 -15.921-8.186 1, .00 23.04 G
ATOM 1372 CZ TYR A 188 -32.913 -15.299 - 9.219 1, .00 23.64 CATOM 1372 CZ TYR A 188 -32.913 -15.299-9.219 1, .00 23.64 C
ATOM 1373 OH TYR A 188 -33.442 -15.330 - 10.490 1, .00 21.55 0ATOM 1373 OH TYR A 188 -33.442 -15.330-10.490 1, .00 21.55 0
ATOM 1374 C TYR A 188 -31.121 -14.143 -3.033 1, .00 24.04 CATOM 1374 C TYR A 188 -31.121 -14.143 -3.033 1, .00 24.04 C
ATOM 1375 0 TYR A 188 -29.946 -14.320 -2.720 1 .00 26.43 0ATOM 1375 0 TYR A 188 -29.946 -14.320 -2.720 1 .00 26.43 0
ATOM 1376 N THR A 189 - 32.094 -14.055 -2.133 1, .00 24.98 NATOM 1376 N THR A 189-32.094 -14.055 -2.133 1, .00 24.98 N
ATOM 1377 CA THR A 189 -31.783 - 14.093 -0.709 1 .00 24.00 CATOM 1377 CA THR A 189 -31.783-14.093 -0.709 1 .00 24.00 C
ATOM 1378 CB THR A 189 -31.922 -12.709 -0.068 1 ■ 00 21.97 CATOM 1378 CB THR A 189 -31.922 -12.709 -0.068 1 ∎ 00 21.97 C
ATOM 1379 061 THR A 189 -31.449 -12.763 1.283 1 .00 23.56 0 ATOM 1380 CG2 THR A 189 -33.382 -12.275 -0.054 1.00 26.15 CATOM 1379 061 THR A 189 -31.449 -12.763 1.283 1 .00 23.56 0 ATOM 1380 CG2 THR A 189 -33.382 -12.275 -0.054 1.00 26.15 C
ATOM 1381 C THR A 189 - 32.699 -15.066 0.016 1. 00 23.40 CATOM 1381 C THR A 189-32.699 -15.066 0.016 1. 00 23.40 C
ATOM 1382 0 THR A 189 -33.831 -15.292 -0.402 1. 00 23.55 0ATOM 1382 0 THR A 189 -33.831 -15.292 -0.402 1.00 23.55 0
ATOM 1383 N ALA A 190 -32.203 -15.641 1. 00 23.37 NATOM 1383 N ALA A 190 -32.203 -15.641 1. 00 23.37 N
ATOM 1384 CA ALA A 190 -32.975 -16.612 1.858 1. 00 24.57 CATOM 1384 CA ALA A 190 -32.975 -16.612 1.858 1.00 24.57 C
ATOM 1385 CB ALA A 190 -32.045 -17.517 2.656 1. 00 23.91 GATOM 1385 CB ALA A 190 -32.045 -17.517 2.656 1. 00 23.91 G
ATOM 1386 C ALA A 190 -33.941 -15.899 2.787 1. 00 24.76 CATOM 1386 C ALA A 190 -33.941 -15.899 2.787 1.00 24.76 C
ATOM 1387 0 ALA A 190 - 34.818 -16.524 3.380 1. 00 25.08 0ATOM 1387 0 ALA A 190-34.818 -16.524 3.380 1. 00 25.08 0
ATOM 1388 N SER A 191 -33.775 -14.585 2.904 1. 00 25.68 NATOM 1388 N SER A 191 -33.775 -14.585 2.904 1. 00 25.68 N
ATOM 1389 , CA SER A 191 - 34.650 -13.768 3.735 1. 00 27.21 CATOM 1389, CA SER A 191-34.650 -13.768 3.735 1. 00 27.21 C
ATOM 1390 CB SER A 191 -34.437 - 14.099 5.213 1. 00 28.97 GATOM 1390 CB SER A 191 -34.437-14.099 5.213 1. 00 28.97 G
ATOM 1391 . OG SER A 191 -35.357 -13.390 6.035 1. 00 31.71 0ATOM 1391 .OG SER A 191 -35.357 -13.390 6.035 1. 00 31.71 0
ATOM 1392 C SER A 191 -34.426 - 12.272 3.526 1. 00 27.94 CATOM 1392 C SER A 191 -34.426-12.272 3.526 1. 00 27.94 C
ATOM 1393 0 SER A 191 -33.298 -11.816 3.343 1. 00 29.02 0ATOM 1393 0 SER A 191 -33.298 -11.816 3.343 1. 00 29.02 0
ATOM 1394 N ILE A 192 -35.516 -11.514 3.543 1. 00 27.31 NATOM 1394 N ILE A 192 -35.516 -11.514 3.543 1. 00 27.31 N
ATOM 1395 CA ILE A 192 - 35.443 -10.071 3.711 1. 00 26.16 CATOM 1395 CA ILE A 192-35.443 -10.071 3.711 1. 00 26.16 C
ATOM 1396 CB ILE A 192 -36.429 -9.347 2.787 1. 00 25.83 CATOM 1396 CB ILE A 192 -36.429 -9.347 2.787 1. 00 25.83 C
ATOM 1397 CG2 ILE A 192 - 36.365 - 7.864 3.021 1. 00 25.09 CATOM 1397 CG2 ILE A 192-36.365-7.864 3.021 1. 00 25.09 C
ATOM 1398 CG1 ILE A 192 - 36.104 -9.656 1.327 1. 00 28.80 CATOM 1398 CG1 ILE A 192-36.104 -9.656 1.327 1. 00 28.80 C
ATOM 1399 CD1 ILE A 192 -36.814 -8.748 0.351 1. 00 26.38 CATOM 1399 CD1 ILE A 192 -36.814 -8.748 0.351 1.00 26.38 C
ATOM 1400 C ILE A 192 -35.837 -9.795 5.155 1. ,00 26.88 GATOM 1400 C ILE A 192 -35.837 -9.795 5.155 1., 00 26.88 G
ATOM 1401 0 ILE A 192 -36.974 -10.044 5.549 1. .00 26.57 0ATOM 1401 0 ILE A 192 -36.974 -10.044 5.549 1. .00 26.57 0
ATOM 1402 N ASP A 193 - 34.895 - 9.303 5.947 1. .00 25.27 NATOM 1402 N ASP A 193-34.895-9.303 5.947 1. .00 25.27 N
ATOM 1403 CA ASP A 193 -35.166 -9.043 7.347 1. .00 26.83 CATOM 1403 CA ASP A 193 -35.166 -9.043 7.347 1. .00 26.83 C
ATOM 1404 CB ASP A 193 -33.890 -9.252 8.、172 1. .00 24.75 CATOM 1404 CB ASP A 193 -33.890 -9.252 8., 172 1. .00 24.75 C
ATOM 1405 C6 ASP A 193 -33.627 - 10.723 8.464 1, .00 26.29 CATOM 1405 C6 ASP A 193 -33.627-10.723 8.464 1, .00 26.29 C
ATOM 1406 0D1 ASP A 193 -34.356 - 11.574 7.916 1, .00 28.85 0ATOM 1406 0D1 ASP A 193 -34.356-11.574 7.916 1, .00 28.85 0
ATOM 1407 0D2 ASP A 193 -32.701 -11.041 9.238 1, .00 26.89 0ATOM 1407 0D2 ASP A 193 -32.701 -11.041 9.238 1, .00 26.89 0
ATOM 1408 C ASP A 193 -35.729 -7.632 7.525 1, .00 27.70 CATOM 1408 C ASP A 193 -35.729 -7.632 7.525 1, .00 27.70 C
ATOM 1409 0 ASP A 193 -36.176 -7.018 6.560 1 .00 28.53 0ATOM 1409 0 ASP A 193 -36.176 -7.018 6.560 1 .00 28.53 0
ATOM 1410 N GLN A 194 -35.716 - 7.125 8.753 1 .00 29.07 NATOM 1410 N GLN A 194 -35.716-7.125 8.753 1 .00 29.07 N
ATOM 1411 CA GLN A "194 -36.383 - 5.865 9.061 1 • 00 31.08 CATOM 1411 CA GLN A "194 -36.383-5.865 9.061 1 • 00 31.08 C
ATOM 1412 CB GLN A 194 - 36.755 -5.824 10.536 1 .00 33.91 CATOM 1412 CB GLN A 194-36.755 -5.824 10.536 1 .00 33.91 C
ATOM 1413 CG GLN A 194 -37.681 -6.944 10.976 1 .00 37.12 CATOM 1413 CG GLN A 194 -37.681 -6.944 10.976 1 .00 37.12 C
ATOM 1414 CD GLN A 194 - 37.751 -7.071 12.486 1 .00 42.16 CATOM 1414 CD GLN A 194-37.751 -7.071 12.486 1 .00 42.16 C
ATOM 1415 0E1 GLN A 194 -37.534 - 6.093 13.216 1 .00 42.61 0 89 ATOM 1415 0E1 GLN A 194 -37.534-6.093 13.216 1 .00 42.61 0 89
0 LL'O 00· L 6L8'9l 196 Ό- 60 ·εζ - 66 L V SIH 90 ISVl INOiV 0 LL'O 00L 6L8'9l 196 Ό-60 εζ-66 L V SIH 90 ISVl INOiV
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0 80 £9 00 ' L 60C'L 9 "92- 861 V RID 230 W01V0 80 £ 9 00 'L 60C'L 9 "92-861 V RID 230 W01V
0 89 Ό9 οο■ ι SLZ '81· ιοζ 'ε ZZl '93- 86 L V ΠΊ9 Lョ 0 mi WO丄 V0 89 Ό9 οο ■ ι SLZ '81 · ιοζ 'ε ZZl '93-86 L V ΠΊ9 L 0 mi WO 丄 V
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0 PL'Z£ 00 089 832 " L - 6L9'62- L61 V NSV vo zzn IN01V0 PL'Z £ 00 089 832 "L-6L9'62- L61 V NSV vo zzn IN01V
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0 οο ·οε 00 ■ι n 'L 90 Z- 9fr8 '82- 96 L V FIJI 90 9Z I INOIV0 οο · οε 00 ■ ι n 'L 90 Z- 9fr8 '82-96 L V FIJI 90 9Z I INOIV
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0 69 ' Ζ 00 L 936 "CL UZ.'U- 198 ·η- L0Z V λΙΘ vo 0L91 W01V0 69 'Ζ 00 L 936 "CL UZ.' U-198
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0 ZS'9Z 00 l Z.68 'ΖΪ ει- LYl '93- 903 V ηョ Ί 0 Z.OSL W01V0 ZS'9Z 00 l Z.68 'ΖΪ ει- LYl '93-903 V η ョ Z 0 Z.OSL W01V
0 OL -n 00 "I 692 'OL 9 6'9l- 908 '83- 903 V ηョ Ί 200 909 L INOIV0 OL -n 00 "I 692 'OL 9 6'9l- 908 '83-903 V η Ί 200 909 L INOIV
0 IJ'6L 00 -L zn' ZiS'SL— -LZ- 903 V Π3Ί LGO 909 L INOIV0 IJ'6L 00 -L zn 'ZiS'SL— -LZ- 903 V Π3Ί LGO 909 L INOIV
0 8 "93 00 Ί SS9 ·6 216 · - S -LZ- 902 V Π3Ί 90 W9L WO丄 V0 8 "93 00 Ί SS9 6 216 ·-S -LZ- 902 V Π3Ί 90 W9L WO 丄 V
0 6L £Z 00 SIL ΌΙ 9ί 1一 998 "9Z- 903 V ηョ Ί ao £051 INOIV0 6L £ Z 00 SIL ΌΙ 9ί 1 1 998 "9Z- 903 V η ョ Ί ao £ 051 INOIV
0 'S3 00 ■I 096 'LL ιεζ. "ει- 60fr 'LZ- 903 V Π3Ί vo 20SL INOIV0 'S3 00 ■ I 096' LL ιεζ. "Ει- 60fr 'LZ- 903 V Π3Ί vo 20SL INOIV
N LO '82 00 ■L 89S-U 0S9'3L- 291 "83- 902 V Πョ Ί N 109 L 匪 VN LO '82 00 L 89S-U 0S9'3L- 291 "83- 902 V Ί N 109 L 匪 V
0 68· 00 'L 63 '3 L .983 -ει- 9 L OS - 902 V 人 19 0 009 L W01V0 68 00 'L 63' 3 L .983 -ει- 9 L OS-902 V 19 0 009 L W01V
0 6£ 'LZ 00 -L 83Z. ' 08fr - 90Ζ V AID 0 66t4 W01V0 6 £ 'LZ 00 -L 83Z.' 08fr-90Ζ V AID 0 66t4 W01V
0 LZ '9Z 00 ■t 6SL εζι οε- S03 V λΊΘ vo 86 INOIV0 LZ '9Z 00 t6SL εζι οε- S03 V λΊΘ vo 86 INOIV
N OZ 'LZ 00 ■I IL9 ΊΙ ZL6 I- 68fr 'ΐε- 903 V 人， 9 N L6 l W01VN OZ 'LZ 00 ■ I IL9 ΊΙ ZL6 I- 68fr' ΐε- 903 V person, 9 N L6 l W01V
0 '62 00 -L ZLL Έ1 Z 9 'OL- S89 Όε- WZ V 0 96frL W01V0 '62 00 -L ZLL Έ1 Z 9 'OL- S89 Όε- WZ V 0 96frL W01V
0 C6'82 00 •L 9fr6 'Zl W9 L- 689■ LS- WZ V oyd 0 INOIV0 C6'82 00 L 9fr6 'Zl W9 L- 689 LS- WZ V oyd 0 INOIV
0 Zl m6Z 00 'I £0VZl £ZZ ' L L- WZ V OHd 90 ½ INOIV0 Zl m 6Z 00 'I £ 0 VZl £ ZZ' L L- WZ V OHd 90 ½ INOIV
0 L LZ 00 ■L L99 -9L tO2'U- εε6 'εε - νοζ V OMd ao INOIV0 L LZ 00 L L99 -9L tO2'U- εε6 'εε-νοζ V OMd ao INOIV
0 ZS SZ 00 ■I 6 ΈΙ 8S0 'OL- 96 Ζϊ,- V oy<d vo WOIV0 ZS SZ 00I 6 ΈΙ 8S0 'OL- 96 Ζϊ,-V oy <d vo WOIV
0 00 •L 6S8'は L£6 '6- 9ん 8 ε- V ao INOIV0 00L 6S8 'is L £ 6' 6-9 9 ε-V ao INOIV
N 96 '93 00 •L 6L8 Zl QLZ '6- 099 ·εε- νοζ V oyd N WOIVN 96 '93 00L 6L8 Zl QLZ '6- 099εε- νοζ V oyd N WOIV
0 9L '83 00 ■L 086 OL ん 8 ん- 9Ζ.8 εε- ΖΟΖ V 311 0 68 WOIV0 9L '83 00 L 086 OL 8-9Ζ.8 εε- ΖΟΖ V 311 0 68 WOIV
0 63 'LZ 00 ■L ん 98·" O .8 - ζ.93 εε- ΖΟΖ V 311 0 88frl WOIV 0 63 'LZ 00 ■ L 98 · "O .8-ζ.93 εε- ΖΟΖ V 311 0 88frl WOIV
SSLU /L00ZdT/13d OAV ATOM 1524 C ALA A 209 -20.093 -15.126 9.901 1.00 23.48 CSSLU / L00ZdT / 13d OAV ATOM 1524 C ALA A 209 -20.093 -15.126 9.901 1.00 23.48 C
ATOM 1525 0 ALA A 209 -19.767 -16.311 9.891 1. 00 24.70 0ATOM 1525 0 ALA A 209 -19.767 -16.311 9.891 1.00 24.70 0
ATOM 1526 N GLY A 210 - 19.262一 14.142 9.570 1. 00 22.33 NATOM 1526 N GLY A 210-19.262 1 14.142 9.570 1. 00 22.33 N
ATOM 1527 CA GLY A 210 -17.889 -14.419 9.169 1. 00 21.86 GATOM 1527 CA GLY A 210 -17.889 -14.419 9.169 1. 00 21.86 G
ATOM 1528 C GLY A 210 -17.139 -15.163 10.252 1. 00 23.63 CATOM 1528 C GLY A 210 -17.139 -15.163 10.252 1. 00 23.63 C
ATOM 1529 0 GLY A 210 -16.464 -16.158 9.989 1. 00 23.82 0ATOM 1529 0 GLY A 210 -16.464 -16.158 9.989 1.00 23.82 0
ATOM 1530 N ASP A 211 -17.272 -14.691 11.487 1. 00 23.68 NATOM 1530 N ASP A 211 -17.272 -14.691 11.487 1. 00 23.68 N
ATOM 1531 CA ASP A 211 -16.663 -15.362 12.620 1. 00 23.09 CATOM 1531 CA ASP A 211 -16.663 -15.362 12.620 1. 00 23.09 C
ATOM 1532 CB ASP A 211 -16,773 -14.486 13.872 1. 00 25.39 CATOM 1532 CB ASP A 211 -16,773 -14.486 13.872 1. 00 25.39 C
ATOM 1533 CG ASP A 211 -15.818 -13.304 13.845 1. 00 28.17 CATOM 1533 CG ASP A 211 -15.818 -13.304 13.845 1. 00 28.17 C
ATOM 1534 0D1 ASP A 211 -14.731 -13.411 13.225 1. 00 29.28 0ATOM 1534 0D1 ASP A 211 -14.731 -13.411 13.225 1. 00 29.28 0
ATOM 1535 0D2 ASP A 211 -16.152 -12.264 14,445 1. 00 30.38 0ATOM 1535 0D2 ASP A 211 -16.152 -12.264 14,445 1. 00 30.38 0
ATOM 1536 C ASP A 211 - 17.281 -16.735 12.881 1. 00 23.71 CATOM 1536 C ASP A 211-17.281 -16.735 12.881 1. 00 23.71 C
ATOM 1537 0 ASP A 211 -16.574 -17.680 13.225 1. 00 22.52 0ATOM 1537 0 ASP A 211 -16.574 -17.680 13.225 1. 00 22.52 0
ATOM 1538 N LYS A 212 -18.594 -16.859 12.707 1. 00 23.71 NATOM 1538 N LYS A 212 -18.594 -16.859 12.707 1. 00 23.71 N
ATOM 1539 CA LYS A 212 -19.240 -18.159 12.886 1. 00 24.67 CATOM 1539 CA LYS A 212 -19.240 -18.159 12.886 1. 00 24.67 C
ATOM 1540 CB LYS A 212 -20.770 -18.038 12.763 1. 00 CATOM 1540 CB LYS A 212 -20.770 -18.038 12.763 1.00 C
ATOM 1541 CG LYS A 212 -21.452 -17.378 13.952 1. 00 29.13 C o t ATOM 1541 CG LYS A 212 -21.452 -17.378 13.952 1. 00 29.13 C o t
ATOM 1542 CD LYS A 212 -22.959 -17.254 13.728 1. .00 32.47 C ATOM 1542 CD LYS A 212 -22.959 -17.254 13.728 1. .00 32.47 C
ATOM 1543 CE LYS A 212 - 23.570 -16.176 14.610 1. ,00 34.43 CATOM 1543 CE LYS A 212-23.570 -16.176 14.610 1., 00 34.43 C
ATOM 1544 NZ LYS A 212 -23.939 -16.662 15.974 1. ,00 39.56 NATOM 1544 NZ LYS A 212 -23.939 -16.662 15.974 1., 00 39.56 N
ATOM 1545 C LYS A 212 -18.727 -19.168 11.858 1. .00 CATOM 1545 C LYS A 212 -18.727 -19.168 11.858 1. .00 C
ATOM 1546 0 LYS A 212 -18.444 -20.318 12.194 1. ,00 25.54 0ATOM 1546 0 LYS A 212 -18.444 -20.318 12.194 1., 00 25.54 0
ATOM 1547 N ILE A 213 -18.614 -18.730 10.608 1. .00 20.35 NATOM 1547 N ILE A 213 -18.614 -18.730 10.608 1. .00 20.35 N
ATOM 1548 CA ILE A 213 -18.181 -19.599 9.527 1. .00 19.88 CATOM 1548 CA ILE A 213 -18.181 -19.599 9.527 1. .00 19.88 C
ATOM 1549 CB ILE A 213 -18.368 -18.903 8.161 1. .00 18.71 cATOM 1549 CB ILE A 213 -18.368 -18.903 8.161 1. .00 18.71 c
ATOM 1550 CG2 ILE A 213 -17.484 -19.534 7.114 1, .00 19.77 cATOM 1550 CG2 ILE A 213 -17.484 -19.534 7.114 1, .00 19.77 c
ATOM 1551 CG1 ILE A 213 -19.830 -19.010 7.730 1. .00 18.53 cATOM 1551 CG1 ILE A 213 -19.830 -19.010 7.730 1. .00 18.53 c
ATOM 1552 CD1 ILE A 213 -20.246 -17.988 6.693 1, .00 12.79 cATOM 1552 CD1 ILE A 213 -20.246 -17.988 6.693 1, .00 12.79 c
ATOM 1553 C ILE A 213 -16.729 -20.023 9.706 1 .00 20.07 cATOM 1553 C ILE A 213 -16.729 -20.023 9.706 1.00 20.07 c
ATOM 1554 0 ILE A 213 -16.403 -21.210 9.620 1, .00 21.62 0ATOM 1554 0 ILE A 213 -16.403 -21.210 9.620 1, .00 21.62 0
ATOM 1555 N PHE A 214 -15.861 -19.059 9.981 1 .00 21.28 NATOM 1555 N PHE A 214 -15.861 -19.059 9.981 1 .00 21.28 N
ATOM 1556 CA PHE A 214 -14.431 -19.335 10.073 1, .00 21.86 CATOM 1556 CA PHE A 214 -14.431 -19.335 10.073 1, .00 21.86 C
ATOM 1557 CB PHE A 214 -13.630 -18.080 9.716 1 • 00 22.80 CATOM 1557 CB PHE A 214 -13.630 -18.080 9.716 1 • 00 22.80 C
ATOM 1558 CG PHE A 214 -13.539 -17.840 8.246 1 .00 24.54 CATOM 1558 CG PHE A 214 -13.539 -17.840 8.246 1 .00 24.54 C
ATOM 1559 CD1 PHE A 214 -12.334 -17.985 7.581 1 ■ 00 27.07 C ATOM 1560 CD2 PHE A 214 -14.674 -17.536 7.511 1.00 25.86 CATOM 1559 CD1 PHE A 214 -12.334 -17.985 7.581 1 ■ 00 27.07 C ATOM 1560 CD2 PHE A 214 -14.674 -17.536 7.511 1.00 25.86 C
ATOM 1561 CE1 PHE A 214 - 12.257 -17.839 6. 200 1. 00 27.82 CATOM 1561 CE1 PHE A 214-12.257 -17.839 6. 200 1. 00 27.82 C
ATOM 1562 CE2 PHE A 214 -14.605 -17.389 6. 129 1. 00 29.63 CATOM 1562 CE2 PHE A 214 -14.605 -17.389 6. 129 1. 00 29.63 C
ATOM 1563 CZ PHE A 214 -13.393 -17.543 5. 473 1. 00 26.51 CATOM 1563 CZ PHE A 214 -13.393 -17.543 5. 473 1. 00 26.51 C
ATOM 1564 G PHE A 214 - 13.996 -19.865 11. 430 1. 00 20.00 CATOM 1564 G PHE A 214-13.996 -19.865 11. 430 1. 00 20.00 C
ATOM 1565 0 PHE A 214 -12.881 -20.345 11. 580 1 00 19.46 0ATOM 1565 0 PHE A 214 -12.881 -20.345 11. 580 1 00 19.46 0
ATOM 1566 N GLY A 215 一 14.882 -19.792 12. 414 1. 00 20.82 NATOM 1566 N GLY A 215 One 14.882 -19.792 12. 414 1.00 20.82 N
ATOM 1567 CA 6LY A 215 -14.560 -20.328 13. 723 1 00 19.69 CATOM 1567 CA 6LY A 215 -14.560 -20.328 13. 723 1 00 19.69 C
ATOM 1568 C GLY A 215 -13.642 -19.399 14.489 1. 00 20.47 CATOM 1568 C GLY A 215 -13.642 -19.399 14.489 1. 00 20.47 C
ATOM 1569 0 GLY A 215 -12.876 -19.834 15. 340 1 00 19. 45 0ATOM 1569 0 GLY A 215 -12.876 -19.834 15. 340 1 00 19. 45 0
ATOM 1570 N THR A 216 -13.707 - 18.114 14. 171 1 00 23. 28 NATOM 1570 N THR A 216 -13.707-18.114 14. 171 1 00 23. 28 N
ATOM 1571 ■CA THR A 216 -12.943 -17.101 14. 889 1 00 25. 76 CATOM 1571 CA THR A 216 -12.943 -17.101 14. 889 1 00 25. 76 C
ATOM 1572 CB THR A 216 -12. 295 -16.099 13. 910 1 00 23. 50 CATOM 1572 CB THR A 216 -12. 295 -16.099 13. 910 1 00 23. 50 C
ATOM 1573 061 THR A 216 - 13. 277 -15.640 12. 973 1 00 24. 09 0ATOM 1573 061 THR A 216-13. 277 -15.640 12. 973 1 00 24. 09 0
ATOM 1574 CG2 THR A 216 -11. 155 - 16.751 13. 156 1 00 22. 35 CATOM 1574 CG2 THR A 216 -11. 155-16.751 13. 156 1 00 22. 35 C
ATOM 1575 G THR A 216 -13. 851 -16.352 15. 865 1 00 29. 11 CATOM 1575 G THR A 216 -13. 851 -16.352 15. 865 1 00 29. 11 C
ATOM 1576 0 THR A 216 - 13. 959 -15.129 15. 825 1 00 28. 38 0ATOM 1576 0 THR A 216-13. 959 -15.129 15. 825 1 00 28. 38 0
ATOM 1577 N LYS A 217 -14. 512 -17.127 16. 719 1 00 35. 21 NATOM 1577 N LYS A 217 -14. 512 -17.127 16. 719 1 00 35. 21 N
ATOM 1578 CA LYS A 217 -15. 332 -16.645 17. 835 1 00 40. 24 CATOM 1578 CA LYS A 217 -15. 332 -16.645 17. 835 1 00 40. 24 C
ATOM 1579 CB LYS A 217 -14. 615 -15.526 18. 593 1 00 41. 56 CATOM 1579 CB LYS A 217 -14. 615 -15.526 18. 593 1 00 41. 56 C
ATOM 1580 CG LYS A 217 -13. 284 -15.959 19. 160 1 00 45. 51 CATOM 1580 CG LYS A 217 -13. 284 -15.959 19. 160 1 00 45. 51 C
ATOM 1581 CD LYS A 217 -13. 264 -17.457 19. 436 1 00 47. 93 CATOM 1581 CD LYS A 217 -13. 264 -17.457 19. 436 1 00 47. 93 C
ATOM 1582 CE LYS A 217 -14. 044 -17.801 20.699 1 00 50. 99 CATOM 1582 CE LYS A 217 -14. 044 -17.801 20.699 1 00 50. 99 C
ATOM 1583 NZ LYS A 217 -13. 171 -18.428 21. 744 1 00 52. 53 NATOM 1583 NZ LYS A 217 -13. 171 -18.428 21. 744 1 00 52. 53 N
ATOM 1584 C LYS A 217 -16. 717 -16.178 17. 429 1 00 41. 81 CATOM 1584 C LYS A 217 -16. 717 -16.178 17. 429 1 00 41. 81 C
ATOM 1585 0 LYS A 217 -17. 687 -16.883 17. 784 1 00 42. 64 0ATOM 1585 0 LYS A 217 -17. 687 -16.883 17. 784 1 00 42. 64 0
ATOM 1586 OXT LYS A 217 一 16. 817 -15.124 16. 762 1 00 45. 71 0ATOM 1586 OXT LYS A 217 1 16. 817 -15.124 16. 762 1 00 45. 71 0
TER 1587 LYS A 217 TER 1587 LYS A 217
ATOM 1588 CB LYS B 11 -50. 871 -35.197 -11. 020 1 00 37. 93 C ATOM 1588 CB LYS B 11 -50. 871 -35.197 -11. 020 1 00 37. 93 C
ATOM 1589 C6 LYS B 11 - 50. 925 -36.241 -9. 919 1 00 40. 68 CATOM 1589 C6 LYS B 11-50. 925 -36.241 -9. 919 1 00 40. 68 C
ATOM 1590 CD LYS B 11 - 51. 366 -35.643 -8 596 1 00 42. 84 CATOM 1590 CD LYS B 11-51. 366 -35.643 -8 596 1 00 42. 84 C
ATOM 1591 CE LYS B 11 -52. 817 - 35.184 -8. 634 1 00 46. 12 CATOM 1591 CE LYS B 11 -52. 817-35.184 -8. 634 1 00 46. 12 C
ATOM 1592 NZ LYS B 11 - 53. 044 -34.009 - 9 537 1 00 47. 61 NATOM 1592 NZ LYS B 11-53. 044 -34.009-9 537 1 00 47. 61 N
ATOM 1593 C LYS B 11 - 48. 423 - 34.930 - 11 463 1 00 36. 39 CATOM 1593 C LYS B 11-48. 423-34.930-11 463 1 00 36. 39 C
ATOM 1594 0 LYS B 11 -47. 686 -35.579 -10 715 1 00 36. 43 0ATOM 1594 0 LYS B 11 -47. 686 -35.579 -10 715 1 00 36. 43 0
ATOM 1595 N LYS B 11 一 49. 941 - 33.026一 11 752 1 00 35 89 N ATOM 1596 CA LYS B 11 -49.679 - 34.244 -10.933 1.00 36.43 CATOM 1595 N LYS B 11 1 49. 941-33.026 1 11 752 1 00 35 89 N ATOM 1596 CA LYS B 11 -49.679-34.244 -10.933 1.00 36.43 C
ATOM 1597 N ILE B 12 -48.191 -34.774 -12.765 1. 00 35.05 ΝATOM 1597 N ILE B 12 -48.191 -34.774 -12.765 1.00 35.05 Ν
ATOM 1598 CA ILE B 12 -46.981 -35.268 -13.416 1. 00 33.47 CATOM 1598 CA ILE B 12 -46.981 -35.268 -13.416 1. 00 33.47 C
ATOM 1599 CB ILE B 12 -47.320 -36.050 -14.703 1. 00 34.10 CATOM 1599 CB ILE B 12 -47.320 -36.050 -14.703 1.00 34.10 C
ATOM 1600 CG2 ILE B 12 -46.040 -36.573 -15.354 1. 00 33.35 CATOM 1600 CG2 ILE B 12 -46.040 -36.573 -15.354 1. 00 33.35 C
ATOM 1601 CG1 ILE B 12 -48.274 -37.200 -14.370 1. 00 34.78 CATOM 1601 CG1 ILE B 12 -48.274 -37.200 -14.370 1.00 34.78 C
ATOM 1602 CD1 ILE B 12 -47.734 - 38, 183 -13.341 1. 00 36.69 CATOM 1602 CD1 ILE B 12 -47.734-38, 183 -13.341 1. 00 36.69 C
ATOM 1603 C ILE B 12 - 46.091 -34.089 -13.784 1. 00 30.96 CATOM 1603 C ILE B 12-46.091 -34.089 -13.784 1. 00 30.96 C
ATOM 1604 0 ILE B 12 -46.501 -33.211 -14.542 1. 00 30.37 0ATOM 1604 0 ILE B 12 -46.501 -33.211 -14.542 1. 00 30.37 0
ATOM 1605 N VAL B 13 - 44.874 -34.064 -13.247 1. 00 30.64 ΝATOM 1605 N VAL B 13-44.874 -34.064 -13.247 1. 00 30.64 Ν
ATOM 1606 CA VAL B 13 -43.995 -32. 921 -13.466 1. 00 30. 40 CATOM 1606 CA VAL B 13 -43.995 -32. 921 -13.466 1. 00 30. 40 C
ATOM 1607 CB VAL B 13 -43.719 -32. 173 -12.150 1. 00 31. 37 CATOM 1607 CB VAL B 13 -43.719 -32. 173 -12.150 1. 00 31. 37 C
ATOM 1608 CG1 VAL B 13 -42.802 -30. 985 -12. 419 1. 00 31. 11 ― CATOM 1608 CG1 VAL B 13 -42.802 -30. 985 -12. 419 1. 00 31. 11 ― C
ATOM 1609 CG2 VAL B 13 -45.035 -31. 701 - 11. 523 1. 00 30. 37 CATOM 1609 CG2 VAL B 13 -45.035 -31. 701-11. 523 1. 00 30. 37 C
ATOM 1610 C VAL B 13 -42.659 -33. 285 -14. 098 1. 00 30. 07 CATOM 1610 C VAL B 13 -42.659 -33. 285 -14. 098 1. 00 30. 07 C
ATOM 1611 0 VAL B 13 -41.825 -33. 952 -13. 478 1. 00 31. 66 0ATOM 1611 0 VAL B 13 -41.825 -33. 952 -13. 478 1. 00 31. 66 0
ATOM 1612 N 6LU B 14 -42.453 - 32. 838 -15. 333 1. 00 29. 23 ΝATOM 1612 N 6LU B 14 -42.453-32. 838 -15. 333 1. 00 29. 23 Ν
ATOM 1613 CA GLU B 14 -32. 955 -15. 970 1. 00 27. 91 CATOM 1613 CA GLU B 14 -32. 955 -15. 970 1. 00 27. 91 C
ATOM 1614 CB 6LU B 14 -41.294 - 33. 066 -17. 494 1. ,00 28. 32 CATOM 1614 CB 6LU B 14 -41.294-33. 066 -17. 494 1., 00 28. 32 C
ATOM 1615 CG GLU B 14 -39.972 -33. 298 -18. 235 1. ,00 31. 95 CATOM 1615 CG GLU B 14 -39.972 -33. 298 -18. 235 1., 00 31. 95 C
ATOM 1616 CD GLU B 14 -40.138 -33. 406 - 19. 754 1. ,00 35. 85 CATOM 1616 CD GLU B 14 -40.138 -33. 406-19. 754 1., 00 35. 85 C
ATOM 1617 0E1 GLU B 14 -41.006 -32. 711 - 20. 317 1. .00 37. 32 0ATOM 1617 0E1 GLU B 14 -41.006 -32. 711-20. 317 1. .00 37. 32 0
ATOM 1618 0E2 GLU B 14 -39.393 - 34. 186 -20. 391 1. ,00 38. 54 0ATOM 1618 0E2 GLU B 14 -39.393-34. 186 -20. 391 1., 00 38. 54 0
ATOM 1619 C GLU B 14 -40.335 -31. 712 -15. 622 1. .00 27. 70 CATOM 1619 C GLU B 14 -40.335 -31. 712 -15. 622 1. .00 27. 70 C
ATOM 1620 0 GLU B 14 -40.649 -30. 614 -16. 083 1. ,00 27. 15 0ATOM 1620 0 GLU B 14 -40.649 -30. 614 -16. 083 1., 00 27. 15 0
ATOM 1621 N VAL B 15 -39.299 -31. 880 -14. 803 1. .00 26. 91 ΝATOM 1621 N VAL B 15 -39.299 -31. 880 -14. 803 1. .00 26. 91 Ν
ATOM 1622 CA VAL B 15 -38.505 -30. 735 -14. 359 1. .00 26. 98 CATOM 1622 CA VAL B 15 -38.505 -30. 735 -14. 359 1. .00 26. 98 C
ATOM 1623 CB VAL B 15 - 37.676 - 31. 077 -13. 088 1. .00 27. 67 CATOM 1623 CB VAL B 15-37.676-31. 077 -13. 088 1. .00 27. 67 C
ATOM 1624 CG1 VAL B 15 -36.793 -29. 901 -12. 703 1. .00 25. 35 CATOM 1624 CG1 VAL B 15 -36.793 -29. 901 -12. 703 1. .00 25. 35 C
ATOM 1625 CG2 VAL B 15 -38.611 - 31. 446 -11. 938 1, .00 23. 27 CATOM 1625 CG2 VAL B 15 -38.611-31. 446 -11. 938 1, .00 23. 27 C
ATOM 1626 C VAL B 15 -37.571 -30. 312 -15. 483 1. .00 26. 70 CATOM 1626 C VAL B 15 -37.571 -30. 312 -15. 483 1. .00 26. 70 C
ATOM 1627 0 VAL B 15 -36.824 - 31. 128 -16. 021 1, .00 26. 41 0ATOM 1627 0 VAL B 15 -36.824-31. 128 -16. 021 1, .00 26. 41 0
ATOM 1628 N LYS B 16 -37.628 -29. 035 -15. 840 1, .00 27. 84 ΝATOM 1628 N LYS B 16 -37.628 -29. 035 -15. 840 1, .00 27. 84 Ν
ATOM 1629 CA LYS B 16 -36.940 -28. 544 - 17. 027 1, .00 30. 05 CATOM 1629 CA LYS B 16 -36.940 -28.544-17. 027 1, .00 30. 05 C
ATOM 1630 CB LYS B 16 -37.961 - 28. 001 -18. 031 1 .00 35. 77 CATOM 1630 CB LYS B 16 -37.961-28. 001 -18. 031 1 .00 35. 77 C
ATOM 1631 CG LYS B 16 -39.063 -28. 986一 18. 402 1, .00 39. 65 C ATOM 1632 CD LYS B 16 -39.814 -28.521 -19.643 1.00 43.69 CATOM 1631 CG LYS B 16 -39.063 -28. 986 1 18. 402 1, .00 39. 65 C ATOM 1632 CD LYS B 16 -39.814 -28.521 -19.643 1.00 43.69 C
ATOM 1633 CE LYS B 16 -41. 302 -28.856 -19.563 1. 00 46.00 CATOM 1633 CE LYS B 16 -41. 302 -28.856 -19.563 1. 00 46.00 C
ATOM 1634 NZ LYS B 16 -42.016 -28.057 -18.514 1. 00 46.78 NATOM 1634 NZ LYS B 16 -42.016 -28.057 -18.514 1. 00 46.78 N
ATOM 1635 C LYS B. 16 -35.902 -27.464 -16.730 1. 00 28.67 CATOM 1635 C LYS B. 16 -35.902 -27.464 -16.730 1. 00 28.67 C
ATOM 1636 0 LYS B 16 - 35.438 -26.779 -17.642 1. 00 28.74 0ATOM 1636 0 LYS B 16-35.438 -26.779 -17.642 1. 00 28.74 0
ATOM 1637 N HIS B 17 -35.552 -27.305 -15.456 1. 00 27.29 NATOM 1637 N HIS B 17 -35.552 -27.305 -15.456 1. 00 27.29 N
ATOM 1638 CA HIS B 17 -34.424 -26.465 -15.055 1. 00 25.97 CATOM 1638 CA HIS B 17 -34.424 -26.465 -15.055 1. 00 25.97 C
ATOM 1639 CB HIS B 17 - 34.135 -26.681 -13.563 1. 00 26.47 CATOM 1639 CB HIS B 17-34.135 -26.681 -13.563 1.00 26.47 C
ATOM 1640 CG HIS B 17 -33.233 -25.651 -12.959 1. 00 27.83 GATOM 1640 CG HIS B 17 -33.233 -25.651 -12.959 1.00 27.83 G
ATOM 1641 CD2 HIS B 17 - 33.470 - 24.700 -12.023 1. 00 28.47 CATOM 1641 CD2 HIS B 17-33.470-24.700 -12.023 1. 00 28.47 C
ATOM 1642 ND1 HIS B 17 -31. 907 -25.517 -13.313 1. 00 25. 41 NATOM 1642 ND1 HIS B 17 -31. 907 -25.517 -13.313 1. 00 25. 41 N
ATOM 1643 CE1 HIS B . 17 -31. 367 -24.527 -12.624 1. 00 27. 36 CATOM 1643 CE1 HIS B. 17 -31. 367 -24.527 -12.624 1. 00 27. 36 C
ATOM 1644 NE2 HIS B 17 -32. 294 -24.014 - 11.834 1. 00 28. 26 . NATOM 1644 NE2 HIS B 17 -32. 294 -24.014-11.834 1. 00 28. 26 .N
ATOM 1645 C HIS B 17 - 33. 197 -26.858 -15.884 1. 00 26. 11 CATOM 1645 C HIS B 17-33. 197 -26.858 -15.884 1. 00 26. 11 C
ATOM 1646 0 HIS B 17 - 32. 894 -28.038 -16.047 1. 00 26. 45 0ATOM 1646 0 HIS B 17-32. 894 -28.038 -16.047 1. 00 26. 45 0
ATOM 1647 N PRO B 18 -32. 468 -25.871 -16.415 1. 00 25. 83 NATOM 1647 N PRO B 18 -32. 468 -25.871 -16.415 1. 00 25. 83 N
ATOM 1648 CD PRO B 18 - 32. 659 - 24.424 -16.243 1. ,00 26. 71 GATOM 1648 CD PRO B 18-32. 659-24.424 -16.243 1., 00 26. 71 G
ATOM 1649 CA PRO B 18 -31. 320 - 26.181 -17.271 1. 00 26. 49 CATOM 1649 CA PRO B 18 -31. 320-26.181 -17.271 1. 00 26. 49 C
ATOM 1650 CB PRO B 18 - 30. 854 -24.813 -17.765 1. 00 26. 14 CATOM 1650 CB PRO B 18-30. 854 -24.813 -17.765 1. 00 26. 14 C
ATOM 1651 CG PRO B 18 -31. 378 -23.853 - 16.768 1. .00 26. 31 CATOM 1651 CG PRO B 18 -31. 378 -23.853-16.768 1. .00 26. 31 C
ATOM 1652 C PRO B 18 -30. 200 -26.966 - 16.583 1. ,00 27. 45 CATOM 1652 C PRO B 18 -30. 200 -26.966-16.583 1., 00 27. 45 C
ATOM 1653 0 PRO B 18 -29. 439 - 27.660 -17.252 1. ,00 27. 96 0ATOM 1653 0 PRO B 18 -29. 439-27.660 -17.252 1., 00 27. 96 0
ATOM 1654 N LEU B 19 - 30. 098 -26.867 -15.260 1. ,00 26. 58 NATOM 1654 N LEU B 19-30. 098 -26.867 -15.260 1., 00 26. 58 N
ATOM 1655 CA LEU B 19 -29. 173 -27.723 -14.520 1. .00 27. 12 CATOM 1655 CA LEU B 19 -29. 173 -27.723 -14.520 1. .00 27. 12 C
ATOM 1656 CB LEU B 19 -29. 009 -27.247 -13.073 1. ,00 28. 46 CATOM 1656 CB LEU B 19 -29. 009 -27.247 -13.073 1., 00 28. 46 C
ATOM 1657 CG LEU B 19 -28. 100 - 26.029 -12.857 1. .00 29. 18 CATOM 1657 CG LEU B 19 -28. 100-26.029 -12.857 1. .00 29. 18 C
ATOM 1658 CD1 LEU B 19 -27. 931 -25.795 - 11.378 1. .00 29. 40 CATOM 1658 CD1 LEU B 19 -27. 931 -25.795-11.378 1. .00 29. 40 C
ATOM 1659 CD2 LEU B 19 - 26. 735 -26.261 -13.507 1, .00 30. 33 CATOM 1659 CD2 LEU B 19-26. 735 -26.261 -13.507 1, .00 30. 33 C
ATOM 1660 C LEU B 19 -29. 586 -29.190 -14.522 1, .00 27. 20 CATOM 1660 C LEU B 19 -29. 586 -29.190 -14.522 1, .00 27. 20 C
ATOM 1661 0 LEU B 19 -28. 731 -30.072 -14.618 1, .00 26. 85 0ATOM 1661 0 LEU B 19 -28. 731 -30.072 -14.618 1, .00 26. 85 0
ATOM 1662 N VAL B 20 - 30. 883 -29.473 -14.431 1, .00 26. 96 NATOM 1662 N VAL B 20-30. 883 -29.473 -14.431 1, .00 26. 96 N
ATOM 1663 CA VAL B 20 -31. 301 -30.872 -14.466 1, .00 28. 22 CATOM 1663 CA VAL B 20 -31. 301 -30.872 -14.466 1, .00 28. 22 C
ATOM 1664 CB VAL B 20 -32. 773 -31.068 -13.985 1, .00 29. 32 CATOM 1664 CB VAL B 20 -32. 773 -31.068 -13.985 1, .00 29. 32 C
ATOM 1665 CG1 VAL B 20 -32. 975 -30.409 -12.628 1, .00 27. 56 CATOM 1665 CG1 VAL B 20 -32. 975 -30.409 -12.628 1, .00 27. 56 C
ATOM 1666 CG2 VAL B 20 -33. 738 -30.513 -14.994 1 .00 31. 48 CATOM 1666 CG2 VAL B 20 -33. 738 -30.513 -14.994 1 .00 31. 48 C
ATOM 1667 C VAL B 20 -31. 136 -31.469 -15.870 1, .00 28. 65 C ATOM 1668 0 VAL B 20 -30.653 -32.593 -16.016 1.00 26.42 0ATOM 1667 C VAL B 20 -31. 136 -31.469 -15.870 1, .00 28. 65 C ATOM 1668 0 VAL B 20 -30.653 -32.593 -16.016 1.00 26.42 0
ATOM 1669 N LYS B 21 -31.524 - 30. 712 -16.896 1. 00 29.51 NATOM 1669 N LYS B 21 -31.524-30. 712 -16.896 1. 00 29.51 N
ATOM 1670 GA LYS B 21 -31■ 322 -31. 130 -18.282 1. 00 28.00 CATOM 1670 GA LYS B 21 -31 ■ 322 -31. 130 -18.282 1. 00 28.00 C
ATOM 1671 CB LYS B 21 - 31.747 -30. 027 - 19.257 1. 00 31.26 CATOM 1671 CB LYS B 21-31.747 -30. 027-19.257 1. 00 31.26 C
ATOM 1672 CG LYS B 21 -33.227 -29. 959 -19.549 1. 00 33.39 CATOM 1672 CG LYS B 21 -33.227 -29. 959 -19.549 1. 00 33.39 C
ATOM 1673 CD LYS B 21 - 33.542 -28. 795 -20.485 1. 00 35.43 CATOM 1673 CD LYS B 21-33.542 -28. 795 -20.485 1. 00 35.43 C
ATOM 1674 CE LYS B 21 -34.991 -28. 855 -20.973 1. 00 37.68 CATOM 1674 CE LYS B 21 -34.991 -28. 855 -20.973 1. 00 37.68 C
ATOM 1675 NZ LYS B 21 -35.497 -27. 529 -21.416 1. 00 37.69 NATOM 1675 NZ LYS B 21 -35.497 -27. 529 -21.416 1. 00 37.69 N
ATOM 1676 C LYS B 21 - 29.855 - 31. 421 -18.509 1. 00 27.22 CATOM 1676 C LYS B 21-29.855-31. 421 -18.509 1. 00 27.22 C
ATOM 1677 0 LYS B 21 -29.499 -32. 373 -19.204 1. 00 26.27 0ATOM 1677 0 LYS B 21 -29.499 -32. 373 -19.204 1. 00 26.27 0
ATOM 1678 N HIS B 22 - 29.002 -30. 584 -17.926 1. 00 25.63 NATOM 1678 N HIS B 22-29.002 -30. 584 -17.926 1. 00 25.63 N
ATOM 1679 CA HIS B 22 -27.572 -30. 695 -18.156 1. 00 25.05 CATOM 1679 CA HIS B 22 -27.572 -30. 695 -18.156 1. 00 25.05 C
ATOM 1680 CB HIS B 22 -26.832 -29. 505 -17.540 1. 00 23.62 CATOM 1680 CB HIS B 22 -26.832 -29. 505 -17.540 1. 00 23.62 C
ATOM 1681 CG HIS B 22 - 25.349 -29. 698 -17.462 1. 00 23.56 CATOM 1681 CG HIS B 22-25.349 -29. 698 -17.462 1. 00 23.56 C
ATOM 1682 CD2 HIS B 22 -24.549 - 30. 055 -16.430 1. ,00 23.90 CATOM 1682 CD2 HIS B 22 -24.549-30. 055 -16.430 1., 00 23.90 C
ATOM 1683 ND1 HIS B 22 -24.519 -29. 544 -18.552 1. 00 24.07 NATOM 1683 ND1 HIS B 22 -24.519 -29.544 -18.552 1.00 24.07 N
ATOM 1684 CE1 HIS B 22 -23.273 -29. 798 -18.194 1. ,00 22.22 CATOM 1684 CE1 HIS B 22 -23.273 -29. 798 -18.194 1., 00 22.22 C
ATOM 1685 NE2 HIS B 22 -23.263 -30. 110 -16.912 1. ,00 22.27 NATOM 1685 NE2 HIS B 22 -23.263 -30. 110 -16.912 1., 00 22.27 N
ATOM 1686 C HIS B 22 -27.038 -31. 991 -17.558 1. ,00 27.10 CATOM 1686 C HIS B 22 -27.038 -31. 991 -17.558 1., 00 27.10 C
ATOM 1687 0 HIS B 22 -26.357 -32. 766 -18.234 1. ,00 27.43 0ATOM 1687 0 HIS B 22 -26.357 -32. 766 -18.234 1., 00 27.43 0
ATOM 1688 N LYS B 23 -27.345 -32. 225 - 16.286 1. .00 26.69 NATOM 1688 N LYS B 23 -27.345 -32. 225-16.286 1. .00 26.69 N
ATOM 1689 CA LYS B 23 -26.791 -33. 375 -15.592 1. .00 26.69 CATOM 1689 CA LYS B 23 -26.791 -33. 375 -15.592 1. .00 26.69 C
ATOM 1690 CB LYS B 23 -27.049 -33. 266 - 14.087 1. ,00 25.01 CATOM 1690 CB LYS B 23 -27.049 -33. 266-14.087 1., 00 25.01 C
ATOM 1691 C6 LYS B 23 -26.282 - 32. 145 -13.401 1. .00 24.88 CATOM 1691 C6 LYS B 23 -26.282-32. 145 -13.401 1. .00 24.88 C
ATOM 1692 CD LYS B 23 -26.940 -31. 746 -12.073 1. .00 24.14 CATOM 1692 CD LYS B 23 -26.940 -31. 746 -12.073 1. .00 24.14 C
ATOM 1693 CE LYS B 23 - 26.392 -30. 418 -11.561 1, .00 23.93 CATOM 1693 CE LYS B 23-26.392 -30. 418 -11.561 1, .00 23.93 C
ATOM 1694 NZ LYS B 23 -24.942 -30. 496 -11.214 1, .00 23.40 NATOM 1694 NZ LYS B 23 -24.942 -30. 496 -11.214 1, .00 23.40 N
ATOM 1695 C LYS B 23 -27.391 - 34. 666 -16.146 1. .00 27.92 CATOM 1695 C LYS B 23 -27.391-34. 666 -16.146 1. .00 27.92 C
ATOM 1696 0 LYS B 23 -26.676 -35. 653 -16.336 1, .00 27.78 0ATOM 1696 0 LYS B 23 -26.676 -35. 653 -16.336 1, .00 27.78 0
ATOM 1697 N LEU B 24 - 28.693 -34. 655 -16.422 1, .00 25.62 NATOM 1697 N LEU B 24-28.693 -34. 655 -16.422 1, .00 25.62 N
ATOM 1698 CA LEU B 24 -29.341 - 35. 833 -16.986 1, .00 28.61 CATOM 1698 CA LEU B 24 -29.341-35. 833 -16.986 1, .00 28.61 C
ATOM 1699 CB LEU B 24 -30.851 -35. 609 -17.121 1 .00 28.56 CATOM 1699 CB LEU B 24 -30.851 -35.609 -17.121 1 .00 28.56 C
ATOM 1700 CG LEU B 24 -31.759 -36. 776 -17.541 1 .00 31.41 CATOM 1700 CG LEU B 24 -31.759 -36. 776 -17.541 1 .00 31.41 C
ATOM 1701 CD1 LEU B 24 -31.642 -37. 009 -19.032 1 .00 32.28 CATOM 1701 CD1 LEU B 24 -31.642 -37. 009 -19.032 1 .00 32.28 C
ATOM 1702 CD2 LEU B 24 -31.398 -38. 038 -16.756 1 ■ 00 28.62 CATOM 1702 CD2 LEU B 24 -31.398 -38. 038 -16.756 1 ■ 00 28.62 C
ATOM 1703 C LEU B 24 一 28.737 -36. 136 -18.351 1 • 00 30.71 C ATOM 1704 0 LEU B 24 -28.653 - 37.294 -18.749 1.00 32.38ATOM 1703 C LEU B 24 1 28.737 -36. 136 -18.351 1 • 00 30.71 C ATOM 1704 0 LEU B 24 -28.653-37.294 -18.749 1.00 32.38
ATOM 1705 N GLY B 25 -28.311 -35. 093 -19. 064 1. 00 29.81ATOM 1705 N GLY B 25 -28.311 -35. 093 -19. 064 1. 00 29.81
ATOM 1706 CA GLY B 25 -27.784 -35. 289 -20. 402 1. 00 28.58ATOM 1706 CA GLY B 25 -27.784 -35. 289 -20. 402 1. 00 28.58
ATOM 1707 C GLY B 25 -26.458 -36. 023 - 20. 353 1. 00 29.44ATOM 1707 C GLY B 25 -26.458 -36. 023-20. 353 1. 00 29.44
ATOM 1708 0 GLY B 25 -26.204 -36. 945 -21. 136 1. 00 28.46ATOM 1708 0 GLY B 25 -26.204 -36. 945 -21. 136 1. 00 28.46
ATOM 1709 N LEU B 26 -25.610 -35. 611 -19. 420 1. 00 26.24ATOM 1709 N LEU B 26 -25.610 -35. 611 -19. 420 1. 00 26.24
ATOM 1710 CA LEU B 26 -24.343 -36. 285 -19. 194 1. 00 27,43ATOM 1710 CA LEU B 26 -24.343 -36. 285 -19. 194 1. 00 27,43
ATOM 1711 CB LEU B 26 -23.611 - 35. 645 -18. 014 1. 00 24.76ATOM 1711 CB LEU B 26 -23.611-35. 645 -18. 014 1. 00 24.76
ATOM 1712 CG LEU B 26 -23.167 -34. 203 -18. 236 1. 00 24.92ATOM 1712 CG LEU B 26 -23.167 -34. 203 -18. 236 1. 00 24.92
ATOM 1713 CD1 LEU B 26 -22.453 - 33. 708 -17. 001 1. 00 27.34ATOM 1713 CD1 LEU B 26 -22.453-33. 708 -17. 001 1. 00 27.34
ATOM 1714 CD2 LEU B 26 -22.260 -34. 122 -19. 448 1. 00 22.42ATOM 1714 CD2 LEU B 26 -22.260 -34. 122 -19. 448 1. 00 22.42
ATOM 1715 C LEU B 26. -24.557 -37. 771 - 18. 907 1. 00 27.87ATOM 1715 C LEU B 26. -24.557 -37. 771-18. 907 1. 00 27.87
ATOM 1716 0 LEU B 26 -23.702 -38. 598 -19. 216 1. 00 28.88ATOM 1716 0 LEU B 26 -23.702 -38. 598 -19. 216 1. 00 28.88
ATOM 1717 N MET B 27 - 25.696 -38. 103 -18. 311 1. 00 28.21ATOM 1717 N MET B 27-25.696 -38. 103 -18. 311 1. 00 28.21
ATOM 1718 CA MET B 27 - 25.940 -39. 467 -17. 872 1. 00 29.99ATOM 1718 CA MET B 27-25.940 -39. 467 -17. 872 1. 00 29.99
ATOM 1719 CB MET B 27 -27.074 -39. 504 -16. 839 1. 00 29.26ATOM 1719 CB MET B 27 -27.074 -39. 504 -16. 839 1. 00 29.26
ATOM 1720 CG MET B 27 - 26.708 - 38. 837 -15. 505 1. 00 27.51ATOM 1720 CG MET B 27-26.708-38. 837 -15. 505 1. 00 27.51
ATOM 1721 SD MET B 27 - 27.946 -39. 023 -14. 206 1. ,00 28.17ATOM 1721 SD MET B 27-27.946 -39. 023 -14. 206 1., 00 28.17
ATOM 1722 CE MET B 27 - 27.645 -40. 713 -13. 666 1. 00 25.93ATOM 1722 CE MET B 27-27.645 -40. 713 -13. 666 1. 00 25.93
ATOM 1723 C MET B 27 -26.263 -40. 385 -19. 042 1. ,00 30.91ATOM 1723 C MET B 27 -26.263 -40. 385 -19. 042 1., 00 30.91
ATOM 1724 0 MET B 27 -26.136 -41. 595 -18. 931 1. .00 30.79ATOM 1724 0 MET B 27 -26.136 -41.595 -18.931 1..00 30.79
ATOM 1725 N ARG B 28 -26.668 -39. 812 - 20. 170 1. ,00 31.26ATOM 1725 N ARG B 28 -26.668 -39. 812-20. 170 1., 00 31.26
ATOM 1726 CA ARG B 28 -27.000 -40. 629 - 21'· 329 1. .00 31.33ATOM 1726 CA ARG B 28 -27.000 -40. 629-21 '· 329 1. .00 31.33
ATOM 1727 CB ARG B 28 -27.893 -39. 846 -22. 296 1. .00 30.43ATOM 1727 CB ARG B 28 -27.893 -39. 846 -22. 296 1. .00 30.43
ATOM 1728 CG ARG B 28 -29.238 -39. 419 -21. 703 1. .00 29.10ATOM 1728 CG ARG B 28 -29.238 -39. 419 -21. 703 1. .00 29.10
ATOM 1729 CD ARG B 28 - 30.185 -38. 934 -22. 781 1. .00 30.15ATOM 1729 CD ARG B 28-30.185 -38. 934 -22. 781 1. .00 30.15
ATOM 1730 NE ARG B 28 - 31.372 - 38. 282 - 22. 236 1. .00 34.17ATOM 1730 NE ARG B 28-31.372-38. 282-22. 236 1. .00 34.17
ATOM 1731 CZ ARG B 28 -32.499 -38. 914 -21. 916 1. .00 33.96ATOM 1731 CZ ARG B 28 -32.499 -38. 914 -21. 916 1. .00 33.96
ATOM 1732 NH1 AR6 B 28 -32.601 -40. 225 - 22. 081 1. .00 36.43ATOM 1732 NH1 AR6 B 28 -32.601 -40. 225-22. 081 1. .00 36.43
ATOM 1733 ' NH2 ARG B 28 -33.527 -38. 235 -21. 435 1. .00 33.65ATOM 1733 'NH2 ARG B 28 -33.527 -38. 235 -21. 435 1. .00 33.65
ATOM 1734 C ARG B 28 -25.741 -41. 116 -22. 048 1. .00 33.05ATOM 1734 C ARG B 28 -25.741 -41. 116 -22. 048 1. .00 33.05
ATOM 1735 0 ARG B 28 - 25.818 - 41. 960 -22. 935 1, .00 30.34ATOM 1735 0 ARG B 28-25.818-41. 960 -22. 935 1, .00 30.34
ATOM 1736 N 6LU B 29 -24.584 -40. 586 -21. 661 1, .00 35.83ATOM 1736 N 6LU B 29 -24.584 -40. 586 -21. 661 1, .00 35.83
ATOM 1737 CA GLU B 29 -23.323 - 41. 012 -22. 251 1, .00 40.96ATOM 1737 CA GLU B 29 -23.323-41. 012 -22. 251 1, .00 40.96
ATOM 1738 CB 6LU B 29 -22.155 - 40. 231 -21. 650 Λ, .00 44.02ATOM 1738 CB 6LU B 29 -22.155-40. 231 -21. 650 Λ, .00 44.02
ATOM 1739 CG GLU B 29 一 22.027 -38. 799 -22. 145 1 • 00 50.63 ATOM 1740 CD GLU B 29 -20.704 - 38.157 -21.744 1.00 53.37 GATOM 1739 CG GLU B 29 1 22.027 -38. 799 -22. 145 1 • 00 50.63 ATOM 1740 CD GLU B 29 -20.704-38.157 -21.744 1.00 53.37 G
ATOM 1741 0E1 GLU B 29 -19.713 -38.898 -21.522 1. 00 54.69 0ATOM 1741 0E1 GLU B 29 -19.713 -38.898 -21.522 1. 00 54.69 0
ATOM 1742 0E2 GLU B 29 -20.657 -36.911 -21.650 1. 00 53.30 0ATOM 1742 0E2 GLU B 29 -20.657 -36.911 -21.650 1.00 53.30 0
ATOM 1743 C GLU B 29 - 23.085 -42.501 -22.030 1. 00 43.27 CATOM 1743 C GLU B 29-23.085 -42.501 -22.030 1. 00 43.27 C
ATOM 1744 0 GLU B 29 -23.022 -42.967 - 20.892 1. 00 43.60 0ATOM 1744 0 GLU B 29 -23.022 -42.967-20.892 1. 00 43.60 0
ATOM 1745 N GLN B 30 -22.938 -43.239 -23.126 1. 00 45.50 NATOM 1745 N GLN B 30 -22.938 -43.239 -23.126 1. 00 45.50 N
ATOM 1746 CA GLN B 30 - 22.747 -44.683 -23.071 1. 00 46.98 CATOM 1746 CA GLN B 30-22.747 -44.683 -23.071 1. 00 46.98 C
ATOM 1747 CB GLN B 30 - 22.730 -45.250 -24.490 1. 00 48.99 CATOM 1747 CB GLN B 30-22.730 -45.250 -24.490 1. 00 48.99 C
ATOM 1748 CG GLN B 30 -22,152 -46.648 -24.615 1. 00 51.57 GATOM 1748 CG GLN B 30 -22,152 -46.648 -24.615 1.00 51.57 G
ATOM 1749 CD GLN B 30 -21.416 -46.837 - 25.933 1. 00 54.28 CATOM 1749 CD GLN B 30 -21.416 -46.837-25.933 1. 00 54.28 C
ATOM 1750 0E1 GLN B 30 - 20.338 -46.270 -26.145 1, 00 54.38 0ATOM 1750 0E1 GLN B 30-20.338 -46.270 -26.145 1, 00 54.38 0
ATOM 1751 ■NE2 GLN B 30 -21.998 -47.631 - 26.830 1. 00 55.18 NATOM 1751NE2 GLN B 30 -21.998 -47.631-26.830 1.00 55.18 N
ATOM 1752 C GLN B 30 -21.464 -45.074 -22.342 1. 00 47.14 CATOM 1752 C GLN B 30 -21.464 -45.074 -22.342 1.00 47.14 C
ATOM 1753 0 GLN B 30 -21.420 - 46.095 1. 00 47.75 0ATOM 1753 0 GLN B 30 -21.420-46.095 1.00 47.75 0
ATOM 1754 N ASP B 31 -20.425 -44.255 -22.484 1. 00 47.04 NATOM 1754 N ASP B 31 -20.425 -44.255 -22.484 1. 00 47.04 N
ATOM 1755 CA ASP B 31 -19.112 -44.572 -21.925 1. 00 47.57 CATOM 1755 CA ASP B 31 -19.112 -44.572 -21.925 1.00 47.57 C
ATOM 1756 CB ASP B 31 -18.019 - 44.158 -22.911 1. 00 50.40 CATOM 1756 CB ASP B 31 -18.019-44.158 -22.911 1. 00 50.40 C
ATOM 1757 CG ASP B 31 -18.078 -42.679 - 23.253 1. 00 53.22 CATOM 1757 CG ASP B 31 -18.078 -42.679-23.253 1. 00 53.22 C
ATOM 1758 0D1 ASP B 31 -17.026 -42.006 - 23.171 1. ,00 55.56 0ATOM 1758 0D1 ASP B 31 -17.026 -42.006-23.171 1., 00 55.56 0
ATOM 1759 0D2 ASP B 31 -19.178 - 42.191 -23.602 1. ,00 53.04 0ATOM 1759 0D2 ASP B 31 -19.178-42.191 -23.602 1., 00 53.04 0
ATOM 1760 C ASP B 31 -18.834 -43.916 -20.568 1. ,00 46.14 CATOM 1760 C ASP B 31 -18.834 -43.916 -20.568 1., 00 46.14 C
ATOM 1761 0 ASP B 31 -17.690 -43.892 -20.105 1. ,00 46.39 0ATOM 1761 0 ASP B 31 -17.690 -43.892 -20.105 1., 00 46.39 0
ATOM 1762 N ILE B 32 - 19.871 -43.381 - 19.933 1. .00 43.92 NATOM 1762 N ILE B 32-19.871 -43.381-19.933 1. .00 43.92 N
ATOM 1763 CA ILE B 32 -19.702 -42.666 - 18.670 1. .00 41.41 CATOM 1763 CA ILE B 32 -19.702 -42.666-18.670 1. .00 41.41 C
ATOM 1764 CB ILE B 32 -21.034 -41.996 -18.248 1. .00 41.29 GATOM 1764 CB ILE B 32 -21.034 -41.996 -18.248 1. .00 41.29 G
ATOM 1765 CG2 ILE B 32 - 22.078 -43.063 -17.931 1. .00 38.58 CATOM 1765 CG2 ILE B 32-22.078 -43.063 -17.931 1. .00 38.58 C
ATOM 1766 CG1 ILE B 32 -20.810 -41.078 -17.046 1, .00 40.51 CATOM 1766 CG1 ILE B 32 -20.810 -41.078 -17.046 1, .00 40.51 C
ATOM 1767 CD1 ILE B 32 -22.048 -40.285 - 16.653 1. .00 38.12 CATOM 1767 CD1 ILE B 32 -22.048 -40.285-16.653 1. .00 38.12 C
ATOM 1768 G ILE B 32 - 19.232 -43.631 -17.575 1, .00 40.02 CATOM 1768 G ILE B 32-19.232 -43.631 -17.575 1, .00 40.02 C
ATOM 1769 0 ILE B 32 -19.699 -44.765 -17.490 1, .00 40.44 0ATOM 1769 0 ILE B 32 -19.699 -44.765 -17.490 1, .00 40.44 0
ATOM 1770 N SER B 33 -18.296 -43.189 -16.746 1 .00 38.74 NATOM 1770 N SER B 33 -18.296 -43.189 -16.746 1 .00 38.74 N
ATOM 1771 CA SER B 33 -17.766 -44.054 - 15.700 1, .00 38.69 CATOM 1771 CA SER B 33 -17.766 -44.054-15.700 1, .00 38.69 C
ATOM 1772 CB SER B 33 -16.535 -43.414 -15.049 1 .00 38.50 CATOM 1772 CB SER B 33 -16.535 -43.414 -15.049 1 .00 38.50 C
ATOM 1773 OG SER B 33 - 16.790 -42.078 -14.651 1 .00 40.89 0ATOM 1773 OG SER B 33-16.790 -42.078 -14.651 1 .00 40.89 0
ATOM 1774 C SER B 33 -18.833 -44.323 -14.648 1 .00 38.97 CATOM 1774 C SER B 33 -18.833 -44.323 -14.648 1 .00 38.97 C
ATOM 1775 0 SER B 33 -19.814一 43.585 -14.550 1 • 00 39.97 0 ATOM 1776 N THR B 34 -18.648 -45.385 -13.870 1.00 37.65 NATOM 1775 0 SER B 33 -19.814 1 43.585 -14.550 1 • 00 39.97 0 ATOM 1776 N THR B 34 -18.648 -45.385 -13.870 1.00 37.65 N
ATOM 1777 CA THR B 34 -19.593 -45.716 -12.810 1. 00 38.20 CATOM 1777 CA THR B 34 -19.593 -45.716 -12.810 1. 00 38.20 C
ATOM 1778 CB THR B 34 -19.252 - 47.076 -12.161 1. 00 38.29 CATOM 1778 CB THR B 34 -19.252-47.076 -12.161 1. 00 38.29 C
ATOM 1779 061 THR B 34 -19.495 - 48.127 -13.102 1. 00 40.16 0ATOM 1779 061 THR B 34 -19.495-48.127 -13.102 1. 00 40.16 0
ATOM 1780 C62 THR B 34 -20.106 -47.311 -10.929 1. 00 38.42 CATOM 1780 C62 THR B 34 -20.106 -47.311 -10.929 1. 00 38.42 C
ATOM 1781 C THR B 34 -19.626 -44.643 -11. 721 1. 00 37.01 CATOM 1781 C THR B 34 -19.626 -44.643 -11. 721 1. 00 37.01 C
ATOM 1782 0 THR B 34 -20.653 -44.426 -11. 081 1. 00 37.10 0ATOM 1782 0 THR B 34 -20.653 -44.426 -11. 081 1. 00 37.10 0
ATOM 1783 N LYS B 35 -18.501 -43.972 - 11. 513 1. 00 36.23 NATOM 1783 N LYS B 35 -18.501 -43.972-11. 513 1. 00 36.23 N
ATOM 1784 CA LYS B 35 -18.419 -42.951 -10. 478 1. 00 35.92 CATOM 1784 CA LYS B 35 -18.419 -42.951 -10. 478 1. 00 35.92 C
ATOM 1785 CB LYS B 35 -16.963 -42.520 -10. 274 1. 00 35.85 cATOM 1785 CB LYS B 35 -16.963 -42.520 -10. 274 1. 00 35.85 c
ATOM 1786 CG LYS B 35 - 16.752 -41.664 - 9. 041 1. 00 36.97 cATOM 1786 CG LYS B 35-16.752 -41.664-9. 041 1. 00 36.97 c
ATOM 1787 CD LYS B 35 -16. 109 -40.336 -9. 380 1, 00 41.34 cATOM 1787 CD LYS B 35 -16. 109 -40.336 -9. 380 1, 00 41.34 c
ATOM 1788 CE LYS B 35 -14. 629 -40.493 -9. 677 1. 00 42.18 cATOM 1788 CE LYS B 35 -14. 629 -40.493 -9. 677 1. 00 42.18 c
ATOM 1789 NZ LYS B 35 —14. 154 -39.505 -10. 696 1. 00 44.20 NATOM 1789 NZ LYS B 35 —14. 154 -39.505 -10. 696 1. 00 44.20 N
ATOM 1790 C LYS B 35 -19. 267 -41.739 -10. 856 1. 00 35.52 CATOM 1790 C LYS B 35 -19. 267 -41.739 -10. 856 1. 00 35.52 C
ATOM 1791 0 LYS B 35 - 20. 111 -41.287 -10. 079 1. 00 34.80 0ATOM 1791 0 LYS B 35-20. 111 -41.287 -10. 079 1. 00 34.80 0
ATOM 1792 N ARG B 36 -19. 046 -12. 058 1. 00 35.03 NATOM 1792 N ARG B 36 -19. 046 -12. 058 1. 00 35.03 N
ATOM 1793 CA ARG B 36 -19. 736 -40.014 -12. 485 1. 00 34.99 CATOM 1793 CA ARG B 36 -19. 736 -40.014 -12. 485 1. 00 34.99 C
ATOM 1794 CB ARG B 36 -19. 144 -39.509 -13. 809 1. ,00 35.85 CATOM 1794 CB ARG B 36 -19. 144 -39.509 -13. 809 1., 00 35.85 C
ATOM 1795 CG ARG B 36 - 19. 664 - 38.140 -14. 239 1. .00 36.63 CATOM 1795 CG ARG B 36-19. 664-38.140 -14. 239 1. .00 36.63 C
ATOM 1796 CD ARG B 36 - 19. 246 -37.037 - 13, 266 1. ,00 36.63 CATOM 1796 CD ARG B 36-19. 246 -37.037-13, 266 1., 00 36.63 C
ATOM 1797 NE ARG B 36 -17. 866 -36.610 -13. 479 1. ,00 37.70 NATOM 1797 NE ARG B 36 -17. 866 -36.610 -13. 479 1., 00 37.70 N
ATOM 1798 CZ ARG B 36 -16. 876 -36.787 -12.607 1. ,00 39.65 CATOM 1798 CZ ARG B 36 -16. 876 -36.787 -12.607 1., 00 39.65 C
ATOM 1799 NH1 ARG B 36 -17. 104 -37.387 -11. 446 1. .00 41.48 NATOM 1799 NH1 ARG B 36 -17. 104 -37.387 -11. 446 1. .00 41.48 N
ATOM 1800 NH2 ARG B 36 -15. 650 -36.371 -12. 900 1. .00 39.81 NATOM 1800 NH2 ARG B 36 -15. 650 -36.371 -12. 900 1. .00 39.81 N
ATOM 1801 C ARG B 36 - 21. 239 -40.271 -12. 629 1. .00 33.54 CATOM 1801 C ARG B 36-21. 239 -40.271 -12. 629 1. .00 33.54 C
ATOM 1802 0 ARG B 36 -22. 055 -39.420 -12. 277 1. .00 33.43 0ATOM 1802 0 ARG B 36 -22. 055 -39.420 -12. 277 1. .00 33.43 0
ATOM 1803 N PHE B 37 -21. 604 -41.449 -13. 126 1. .00 NATOM 1803 N PHE B 37 -21. 604 -41.449 -13. 126 1. .00 N
ATOM 1804 CA PHE B 37 -23. 016 -41.783 -13. 297 1, .00 31.46 CATOM 1804 CA PHE B 37 -23. 016 -41.783 -13. 297 1, .00 31.46 C
ATOM 1805 CB PHE B 37 - 23. 174 -43.121 -14. 042 1, .00 29.56 cATOM 1805 CB PHE B 37-23. 174 -43.121 -14. 042 1, .00 29.56 c
ATOM 1806 CG PHE B 37 -24. 606 -43.472 -14. 367 1, .00 29.47 cATOM 1806 CG PHE B 37 -24. 606 -43.472 -14. 367 1, .00 29.47 c
ATOM 1807 CD1 PHE B 37 -25. 133 -43.202 -15. 624 1 .00 29.71 cATOM 1807 CD1 PHE B 37 -25. 133 -43.202 -15. 624 1 .00 29.71 c
ATOM 1808 CD2 PHE B 37 -25. 421 -44.067 -13. 419 1. .00 26.23 cATOM 1808 CD2 PHE B 37 -25. 421 -44.067 -13. 419 1. .00 26.23 c
ATOM 1809 CE1 PHE B 37 -26. 448 - 43.521 -15. 926 1 • 00 30.25 cATOM 1809 CE1 PHE B 37 -26. 448-43.521 -15. 926 1 • 00 30.25 c
ATOM 1810 CE2 PHE B 37 -26. 729 -44.388 -13. 710 1 • 00 27.99 cATOM 1810 CE2 PHE B 37 -26. 729 -44.388 -13. 710 1 • 00 27.99 c
ATOM 1811 GZ PHE B 37 一 27. 249 —44.115一 14. 965 1 • 00 30.25 c ATOM 1812 C PHE B 37 - 23.678 -41.865 -11.925 1.00 30.52 CATOM 1811 GZ PHE B 37 One 27. 249 —44.115 One 14. 965 1 • 00 30.25 c ATOM 1812 C PHE B 37-23.678 -41.865 -11.925 1.00 30.52 C
ATOM 1813 0 PHE B 37 - 24.792 -41■ 390 -11.736 1. 00 30.45 0ATOM 1813 0 PHE B 37-24.792 -41 ■ 390 -11.736 1. 00 30.45 0
ATOM 1814 N ARG B 38 -22.971 -42.449 -10.968 1. 00 31.10 NATOM 1814 N ARG B 38 -22.971 -42.449 -10.968 1. 00 31.10 N
ATOM 1815 CA ARG B 38 -23.481 -42.569 -9.610 1. 00 34.63 CATOM 1815 CA ARG B 38 -23.481 -42.569 -9.610 1.00 34.63 C
ATOM 1816 CB ARG B 38 -22.514 -43.406 -8.763 1. 00 36.41 CATOM 1816 CB ARG B 38 -22.514 -43.406 -8.763 1. 00 36.41 C
ATOM 1817 CG ARG B 38 -23.041 -43.761 -7.373 1. 00 42.74 CATOM 1817 CG ARG B 38 -23.041 -43.761 -7.373 1. 00 42.74 C
ATOM 1818 CD ARG B 38 -21. 913 - 44.231 -6.454 1. 00 45.05 CATOM 1818 CD ARG B 38 -21.913-44.231 -6.454 1.00 45.05 C
ATOM 1819 NE ARG B 38 -21. 268 -45.439 -6.964 1. 00 50.95 NATOM 1819 NE ARG B 38 -21. 268 -45.439 -6.964 1. 00 50.95 N
ATOM 1820 CZ AR6 B 38 -19.971 - 45.546 -7.243 1. 00 51.90 CATOM 1820 CZ AR6 B 38 -19.971-45.546 -7.243 1.00 51.90 C
ATOM 1821 NH1 ARG B 38 -19.155 -44.511 - 7.066 1. 00 51.22 NATOM 1821 NH1 ARG B 38 -19.155 -44.511-7.066 1. 00 51.22 N
ATOM 1822 NH2 ARG B 38 -19.491 - I46.697 - 7.698 1. 00 51.47 NATOM 1822 NH2 ARG B 38 -19.491-I46.697-7.698 1. 00 51.47 N
ATOM. 1823 C ARG B 38 -23.648 -9.001 1. 00 33.37 CATOM. 1823 C ARG B 38 -23.648 -9.001 1.00 33.37 C
ATOM 1824 0 ARG B 38 - 24.638 -40.884O C - 8.323 1. 00 32.68 0ATOM 1824 0 ARG B 38-24.638 -40.884O C-8.323 1. 00 32.68 0
ATOM 1825 N GLU B 39 - 22.676 -40.318 - 9.273 1. 00 31.91 NATOM 1825 N GLU B 39-22.676 -40.318-9.273 1. 00 31.91 N
ATOM 1826 CA GLU B 39 -22.667 -38.969 -8.736 1. 00 31.30 CATOM 1826 CA GLU B 39 -22.667 -38.969 -8.736 1. 00 31.30 C
ATOM 1827 CB GLU B 39 -21. 319 -38.316 - 9.037 1. 00 33.48 CATOM 1827 CB GLU B 39 -21. 319 -38.316-9.037 1. 00 33.48 C
ATOM 1828 CG GLU B 39 -21. 052 -37.011 -8.312 1. 00 40.15 CATOM 1828 CG GLU B 39 -21. 052 -37.011 -8.312 1. 00 40.15 C
ATOM 1829 CD GLU B 39 -19.585 -36.604 -8.392 1. 00 43.88 CATOM 1829 CD GLU B 39 -19.585 -36.604 -8.392 1. 00 43.88 C
ATOM 830 0E1 GLU B 39 -18.795 -37.358 - 9.006 1. ,00 46.54 0ATOM 830 0E1 GLU B 39 -18.795 -37.358-9.006 1., 00 46.54 0
ATOM 1831 0E2 GLU B 39 -19. 220 -35.541 - 7.842 1. , 00 43.93 0ATOM 1831 0E2 GLU B 39 -19. 220 -35.541-7.842 1., 00 43.93 0
ATOM 1832 C GLU B 39 -23. 803 - 38.149 -9.344 1. , 00 29.61 CATOM 1832 C GLU B 39 -23. 803-38.149 -9.344 1., 00 29.61 C
ATOM 1833 0 GLU B 39 -24. 480 -37.398 - 8.645 1. 00 28.47 0ATOM 1833 0 GLU B 39 -24. 480 -37.398-8.645 1. 00 28.47 0
ATOM 1834 N LEU B 40 -24. 015 -38.298 -10.646 1. .00 27.00 NATOM 1834 N LEU B 40 -24. 015 -38.298 -10.646 1. .00 27.00 N
ATOM 1835 CA LEU B 40 -25. 014 -37.497 -11.328 1. , 00 26.24 CATOM 1835 CA LEU B 40 -25. 014 -37.497 -11.328 1., 00 26.24 C
ATOM 1836 CB LEU B 40 - 24. 861 -37.643 -12.840 1. , 00 25.85 CATOM 1836 CB LEU B 40-24. 861 -37.643 -12.840 1., 00 25.85 C
ATOM 1837 CG LEU B 40 -23. 654 -36.912 -13.443 1. .00 24.52 CATOM 1837 CG LEU B 40 -23. 654 -36.912 -13.443 1. .00 24.52 C
ATOM 1838 CD1 LEU B 40 - 23. 568 - 37.209 - 14.933 1. .00 22.35 CATOM 1838 CD1 LEU B 40-23. 568-37.209-14.933 1. .00 22.35 C
ATOM 1839 CD2 LEU B 40 -23. 783 -35.407 -13.200 1. ■ 00 20.97 CATOM 1839 CD2 LEU B 40 -23. 783 -35.407 -13.200 1. ■ 00 20.97 C
ATOM 1840 C LEU B 40 - 26. 416 -37.897 - 10.897 1, .00 26.56 CATOM 1840 C LEU B 40-26. 416 -37.897-10.897 1, .00 26.56 C
ATOM 1841 0 LEU B 40 -27. 304 - 37.056 -10.785 1, .00 26.26 0ATOM 1841 0 LEU B 40 -27. 304-37.056 -10.785 1, .00 26.26 0
ATOM 1842 N ALA B 41 -26. 602 -39.186 -10.638 1, .00 26.98 NATOM 1842 N ALA B 41 -26. 602 -39.186 -10.638 1, .00 26.98 N
ATOM 1843 CA ALA B 41 -27. 876 -39.704 -10.165 1 .00 24.60 CATOM 1843 CA ALA B 41 -27. 876 -39.704 -10.165 1 .00 24.60 C
ATOM 1844 CB ALA B 41 -27. 757 -41.199 -9.901 1 .00 26.06 CATOM 1844 CB ALA B 41 -27. 757 -41.199 -9.901 1 .00 26.06 C
ATOM 1845 C ALA B 41 -28. 323 -38.986 -8.897 1, ■ 00 23.90 CATOM 1845 C ALA B 41 -28. 323 -38.986 -8.897 1, ■ 00 23.90 C
ATOM 1846 0 ALA B 41 - 29. .473 - 38.582 -8.767 1 .00 22.22 0ATOM 1846 0 ALA B 41-29..473-38.582 -8.767 1 .00 22.22 0
ATOM 1847 N SER B 42 -27. ,407 -38.826 —7, 957 1 ■ 00 24.92 N ATOM 1848 CA SER B 42 -27.748 -38. t79 -6.699 1.00 25.26 CATOM 1847 N SER B 42 -27., 407 -38.826 —7, 957 1 ∎ 00 24.92 N ATOM 1848 CA SER B 42 -27.748 -38.t79 -6.699 1.00 25.26 C
ATOM 1849 CB SER B 42 -26.640 -38.428 -5.680 1. 00 26.62 CATOM 1849 CB SER B 42 -26.640 -38.428 -5.680 1.00 26.62 C
ATOM 1850 OG SER B 42 - 27.169 -38.496 -4.367 1. 00 33.51 0ATOM 1850 OG SER B 42-27.169 -38.496 -4.367 1.00 33.51 0
ATOM 1851 G SER B 42 -27.976 -36.674 -6. 881 1. 00 24.86 CATOM 1851 G SER B 42 -27.976 -36.674 -6. 881 1. 00 24.86 C
ATOM 1852 0 SER B 42 -28.915 -36.105 -6. 319 1. 00 25.77 0ATOM 1852 0 SER B 42 -28.915 -36.105 -6. 319 1. 00 25.77 0
ATOM 1853 N 6LU B 43 -27.123 - 36.031 -7. 671 1. 00 23.12 NATOM 1853 N 6LU B 43 -27.123-36.031 -7. 671 1. 00 23.12 N
ATOM 1854 CA GLU B 43 -27.287 -34.611 - 7. 950 1. 00 25.47 CATOM 1854 CA GLU B 43 -27.287 -34.611-7. 950 1. 00 25.47 C
ATOM 1855 CB GLU B 43 -26.200 - 34.113 8. 912 1. 00 23.38 CATOM 1855 CB GLU B 43 -26.200-34.113 8. 912 1. 00 23.38 C
ATOM 1856 CG GLU B 43 -24.826 -33.978 - 8. 264 1. 00 24.93 CATOM 1856 CG GLU B 43 -24.826 -33.978-8. 264 1. 00 24.93 C
ATOM 1857 CD GLU B 43 -23.747 -33.538 -9. 238 1. 00 24.46 CATOM 1857 CD GLU B 43 -23.747 -33.538 -9. 238 1. 00 24.46 C
ATOM 1858 0E1 GLU B 43 -24.087 -32.918 -10. 263 1. 00 25.02 0ATOM 1858 0E1 GLU B 43 -24.087 -32.918 -10. 263 1. 00 25.02 0
ATOM 1859 •0E2 GLU B 43 - 22.556 -33.810 -8. 973 1. 00 24.25 0ATOM 1859 0E2 GLU B 43-22.556 -33.810 -8. 973 1.00 24.25 0
ATOM 1860 C GLU B 43 -28.661 - 34.331 -8. 538 1. 00 26.23 CATOM 1860 C GLU B 43 -28.661-34.331 -8. 538 1. 00 26.23 C
ATOM 1861 0 GLU B 43 -29.330 -33.388 - 8. 126 1. 00 28.40 0ATOM 1861 0 GLU B 43 -29.330 -33.388-8. 126 1. 00 28.40 0
ATOM 1862 N VAL B 44 -29.086 -35.152 -9. 496 1. 00 25.37 NATOM 1862 N VAL B 44 -29.086 -35.152 -9. 496 1. 00 25.37 N
ATOM 1863 CA VAL B 44 -30.386 -34.949 -10. 107 1. 00 24.40 CATOM 1863 CA VAL B 44 -30.386 -34.949 -10. 107 1. 00 24.40 C
ATOM 1864 CB VAL B 44 - 30.580 -35.829 -11. 349 1. 00 24.77 CATOM 1864 CB VAL B 44-30.580 -35.829 -11. 349 1. 00 24.77 C
ATOM 1865 C61 VAL B 44 -32.006 - 35.689 -11. 863 1. 00 22.78 CATOM 1865 C61 VAL B 44 -32.006-35.689 -11. 863 1. 00 22.78 C
ATOM 1866 C62 VAL B 44 -29.588 -35.410 - 12. 437 1. 00 25.28 CATOM 1866 C62 VAL B 44 -29.588 -35.410-12. 437 1. 00 25.28 C
ATOM 1867 C VAL B 44 -31■ 486 -35.255 - 9. 109 1. 00 24.74 CATOM 1867 C VAL B 44 -31 ■ 486 -35.255-9. 109 1. 00 24.74 C
ATOM 1868 0 VAL B 44 -32.437 -34.479 -8. 970 1. .00 23.92 0ATOM 1868 0 VAL B 44 -32.437 -34.479 -8. 970 1. .00 23.92 0
ATOM 1869 N GLY B 45 - 31.349 -36.379 -8. 409 1. 00 23.03 NATOM 1869 N GLY B 45-31.349 -36.379 -8. 409 1. 00 23.03 N
ATOM 1870 CA GLY B 45 -32.300 -36.714 - 7.367 1. ,00 23.71 CATOM 1870 CA GLY B 45 -32.300 -36.714-7.367 1., 00 23.71 C
ATOM 1871 C GLY B 45 -32. 36 - 35.561 -6. 390 1. .00 25.82 CATOM 1871 C GLY B 45 -32. 36-35.561 -6. 390 1. .00 25.82 C
ATOM 1872 0 GLY B 45 -33.539 -35.211 -5. 968 1. ,00 26.84 0ATOM 1872 0 GLY B 45 -33.539 -35.211 -5. 968 1., 00 26.84 0
ATOM 1873 N SER B 46 -31.307 -34.953 -6. 051 1. ,00 25.64 NATOM 1873 N SER B 46 -31.307 -34.953 -6. 051 1., 00 25.64 N
ATOM 1874 CA SER B 46 -31.290 - 33.803 -5. 168 1. .00 25.83 CATOM 1874 CA SER B 46 -31.290-33.803 -5. 168 1. .00 25.83 C
ATOM 1875 CB SER B 46 -29.858 -33.312 -4. 990 1. ,00 26.51 CATOM 1875 CB SER B 46 -29.858 -33.312 -4. 990 1., 00 26.51 C
ATOM 1876 OG SER B 46 -29.823 -32.120 -4. 237 1. ,00 28.60 0ATOM 1876 OG SER B 46 -29.823 -32.120 -4. 237 1., 00 28.60 0
ATOM 1877 C SER B 46 -32.153 - 32.671 -5. 698 1, .00 26.12 CATOM 1877 C SER B 46 -32.153-32.671 -5. 698 1, .00 26.12 C
ATOM 1878 0 SER B 46 -32.998 -32.138 -4. 982 1, .00 26.12 0ATOM 1878 0 SER B 46 -32.998 -32.138 -4. 982 1, .00 26.12 0
ATOM 1879 N LEU B 47 -31.939 -32.307 -6. 957 1, .00 27.59 NATOM 1879 N LEU B 47 -31.939 -32.307 -6. 957 1, .00 27.59 N
ATOM 1880 CA LEU B 47 -32.717 -31.245 -7. 587 1, .00 27.00 CATOM 1880 CA LEU B 47 -32.717 -31.245 -7. 587 1, .00 27.00 C
ATOM 1881 CB LEU B 47 - 32.129 -30.927 -8. 965 1 .00 25.15 CATOM 1881 CB LEU B 47-32.129 -30.927 -8. 965 1 .00 25.15 C
ATOM 1882 CG LEU B 47 - 30.684 -30.420 -8. 888 1, .00 25.88 CATOM 1882 CG LEU B 47-30.684 -30.420 -8. 888 1, .00 25.88 C
ATOM 1883 GD1 LEU B 47 -30.122 -30.195 -10. 280 1 .00 25.86 C 5 ATOM 1883 GD1 LEU B 47 -30.122 -30.195 -10. 280 1 .00 25.86 C Five
ATOM 1884 CD2 LEU B 47 -30.645 -29, 126 -8.087 1. 00 22.32 CATOM 1884 CD2 LEU B 47 -30.645 -29, 126 -8.087 1. 00 22.32 C
ATOM 1885 C LEU B 47 -34.204 -7.708 1. 00 27.75 CATOM 1885 C LEU B 47 -34.204 -7.708 1. 00 27.75 C
ATOM 1886 0 LEU B 47 -35.082 - 30.769 -7.542 1. 00 27.73 0ATOM 1886 0 LEU B 47 -35.082-30.769 -7.542 1.00 27.73 0
ATOM 1887 N LEU B 48 -34.489 -32.886 -7.983 1. 00 27.20 NATOM 1887 N LEU B 48 -34.489 -32.886 -7.983 1.00 27.20 N
ATOM 1888 CA LEU B 48 -35.874 -33.335 -8.089 1. 00 28.82 CATOM 1888 CA LEU B 48 -35.874 -33.335 -8.089 1. 00 28.82 C
ATOM 1889 CB LEU B 48 - 35.932 -34.795 -8.546 1. 00 26.78 CATOM 1889 CB LEU B 48-35.932 -34.795 -8.546 1. 00 26.78 C
ATOM 1890 CG LEU B 48 -35.475 -35.039 -9.983 1. 00 27.84 CATOM 1890 CG LEU B 48 -35.475 -35.039 -9.983 1.00 27.84 C
ATOM 1891 CD1 LEU B 48 -35.660 -36.515 -10.351 1. 00 23.29 CATOM 1891 CD1 LEU B 48 -35.660 -36.515 -10.351 1. 00 23.29 C
ATOM 1892 CD2 LEU B 48 - 36.275 -34.129 -10.914 1. 00 25.68 CATOM 1892 CD2 LEU B 48-36.275 -34.129 -10.914 1. 00 25.68 C
ATOM 1893 C LEU B 48 - 36.566 -33.201 - 6.738 1. 00 29.58 CATOM 1893 C LEU B 48-36.566 -33.201-6.738 1. 00 29.58 C
ATOM 1894 0 LEU B 48 -37.761一 32.899 -6.663 1. 00 29.00 0ATOM 1894 0 LEU B 48 -37.761 One 32.899 -6.663 1.00 29.00 0
ATOM 1895 N THR B 49 - 35.800 - 33.427 -5.673 1. 00 29.70 NATOM 1895 N THR B 49-35.800-33.427 -5.673 1. 00 29.70 N
ATOM 1896 CA THR B 49 - 36.328 -33.35£ (>7 -4.317 1. 00 29.76 CATOM 1896 CA THR B 49-36.328 -33.35 £ (> 7 -4.317 1. 00 29.76 C
ATOM 1897 CB THR B 49 -35.276 -33.834 -3.276 1. 00 29.51 CATOM 1897 CB THR B 49 -35.276 -33.834 -3.276 1. 00 29.51 C
ATOM 1898 0G1 THR B 49 - 34.956 - 35.213 - 3.508 1. 00 26.64 0ATOM 1898 0G1 THR B 49-34.956-35.213-3.508 1.00 26.64 0
ATOM 1899 CG2 THR B 49 -35.809 -33.667 -1.863 1. 00 23.67 CATOM 1899 CG2 THR B 49 -35.809 -33.667 -1.863 1.00 23.67 C
ATOM 1900 C THR B 49 -36.743 -31.924 -3.996 1. , 00 30.51 CATOM 1900 C THR B 49 -36.743 -31.924 -3.996 1., 00 30.51 C
ATOM 1901 0 THR B 49 -37.702 - 3.259 1. ,00 29.09 0ATOM 1901 0 THR B 49 -37.702-3.259 1., 00 29.09 0
ATOM 1902 N TYR B 50 - 36.028 -30.959 -4.567 1. ,00.31.19 NATOM 1902 N TYR B 50-36.028 -30.959 -4.567 1., 00.31.19 N
ATOM 1903 CA TYR B 50 - 36.350 -29.554 -4.345 1. , 00 33.26 CATOM 1903 CA TYR B 50-36.350 -29.554 -4.345 1., 00 33.26 C
ATOM 1904 CB TYR B 50 -35.261 - 28.658 - 4.939 1. .00 32.80 CATOM 1904 CB TYR B 50 -35.261-28.658-4.939 1. .00 32.80 C
ATOM 1905 CG TYR B 50 -35.409 -27.197 - 4.582 1. .00 32.60 CATOM 1905 CG TYR B 50 -35.409 -27.197-4.582 1. .00 32.60 C
ATOM 1906 CD1 TYR B 50 - 35.099 - 26.739 - 3.308 1. .00 34.28 CATOM 1906 CD1 TYR B 50-35.099-26.739-3.308 1. .00 34.28 C
ATOM 1907 CE1 TYR B 50 -35.223 -25.403 -2.979 1. , 00 32.81 CATOM 1907 CE1 TYR B 50 -35.223 -25.403 -2.979 1., 00 32.81 C
ATOM 1908 CD2 TYR B 50 -35.850 -26.273 -5.518 1. .00 30.88 CATOM 1908 CD2 TYR B 50 -35.850 -26.273 -5.518 1. .00 30.88 C
ATOM 1909 CE2 TYR B 50 -35.977 -24.937 - 5.197 1, .00 31.80 CATOM 1909 CE2 TYR B 50 -35.977 -24.937-5.197 1, .00 31.80 C
ATOM 1910 CZ TYR B 50 - 35.661 -24.507 -3.927 1, .00 32.00 CATOM 1910 CZ TYR B 50-35.661 -24.507 -3.927 1, .00 32.00 C
ATOM 1911 OH TYR B 50 -35.777 - 23.176 - 3.601 1, .00 31.01 0ATOM 1911 OH TYR B 50 -35.777-23.176-3.601 1, .00 31.01 0
ATOM 1912 C TYR B 50 -37.715 -29.169 -4.922 1, .00 33.12 CATOM 1912 C TYR B 50 -37.715 -29.169 -4.922 1, .00 33.12 C
ATOM 1913 0 TYR B 50 -38.533 -28.561 - 4.232 1 .00 33.42 0ATOM 1913 0 TYR B 50 -38.533 -28.561-4.232 1 .00 33.42 0
ATOM 1914 N 6LU B 51 -37.974 -29.517 - 6.177 1, ■ 00 34.84 NATOM 1914 N 6LU B 51 -37.974 -29.517-6.177 1, ■ 00 34.84 N
ATOM 1915 CA 6LU B 51 - 39.289 -29.236 -6.744 1 .00 35.77 CATOM 1915 CA 6LU B 51-39.289 -29.236 -6.744 1 .00 35.77 C
ATOM 1916 CB 6LU B 51 -39.311 -29.522 -8.251 1, ■ 00 36.73 CATOM 1916 CB 6LU B 51 -39.311 -29.522 -8.251 1, ■ 00 36.73 C
ATOM 1917 CG GLU B 51 -39.195 - 28.264 -9.126 1, .00 39.18 CATOM 1917 CG GLU B 51 -39.195-28.264 -9.126 1, .00 39.18 C
ATOM 1918 CD 6LU B 51 -37.783 - 28.061 -9.653 1 .00 42.14 CATOM 1918 CD 6LU B 51 -37.783-28.061 -9.653 1 .00 42.14 C
ATOM 1919 0E1 GLU B 51 -37.495 -26.993 -10.245 1 ■ 00 38.37 0 Z8 ATOM 1919 0E1 GLU B 51 -37.495 -26.993 -10.245 1 ∎ 00 38.37 0 Z8
0 9 ,8ε 00' ι 390 •ε Z.L9'92- 889 n- 99 g nョ， 0 SS6L IN01V 0 9, 8ε 00 'ι 390 • ε Z.L9'92- 889 n- 99 g n, 0 SS6L IN01V
0 9S ·6ε 00' ι 02Ζ •ε i£L τζ- 99 a nai 0 WOIV0 9S 6ε 00 'ι 02Ζε i £ L τζ- 99 a nai 0 WOIV
0 82 ■ζ.ε 00' ι 899 'τ 699 '0£- 939 'θ - 99 9 Π3Ί ZQD £961 W01V0 82 ζ.ε 00 'ι 899' τ 699 '0 £-939' θ-99 9 Π3Ί ZQD £ 961 W01V
0 20 ■8ε 00' ι 099 S92■ ιε- 86ん 'Ζ - 99 a Π3Ί IQO 396 L IN01V0 20 ■ 8ε 00 'ι 099 S92 ■ ιε- 86' Ζ-99 a Π3Ί IQO 396 L IN01V
0 εε ■^ε 00 ι 9PL Ζ ιρρ 'οε - ΖΖΪ Z - 9S g Π31 90 156 L WOIV0 εε ■ ^ ε 00 ι 9PL Ζ ιρρ 'οε-ΖΖΪ Z-9S g Π31 90 156 L WOIV
0 OL ■8ε 00 ι LL9 'τ 8Ζ.6 '82； - 9S g nai ao 096 L WOIV0 OL ■ 8ε 00 ι LL9 'τ 8Ζ.6 '82 ；-9S g nai ao 096 L WOIV
0 L8 ■8ε 00 ι L2Z ζ ZZL 82- 92 s Π3Ί vo 6fr6L I/UOIV0 L8 8ε 00 ι L2Z ζ ZZL 82- 92 s Π3Ί vo 6fr6L I / UOIV
N οε ■8ε 00 ι 988 Ό d Z .82- 99 g nan N 1N01VN οε 8ε 00 ι 988 Ό d Z .82- 99 g nan N 1N01V
0 63 ■6ε 00 ι 6 Ό 693 "82- gg a dSV 0 mi WOIV0 63 ■ 6ε 00 ι 6 Ό 693 "82-gg a dSV 0 mi WOIV
0 03 'LZ 00 LVZ Ό 990 "82- 93 g dSV 0 9t-6L WOiV0 03 'LZ 00 LVZ Ό 990 "82-93 g dSV 0 9t-6L WOiV
0 80 00 ι 2£Ζ ■L - 9S .οε - 8εε -z.fr- 99 g dSV 200 ^61 IN01V0 80 00 ι 2 £ Ζ L-9S .οε-8εε -z.fr- 99 g dSV 200 ^ 61 IN01V
0 ιε ■w 00 L 628 •L- S6 'οε- 832 'Sfr- 99 8 dSV LOO WOIV0 ιε w 00 L 628L-S6 'οε- 832' Sfr- 99 8 dSV LOO WOIV
0 00 ι 8C9 ■L- 868 "62- οιε '9Ρ- 99 g dSV DO £V6l KllOiV0 00 ι 8C9 L- 868 "62- οιε '9Ρ- 99 g dSV DO £ V6l KllOiV
0 69 ■9ε 00 ι 806 Μ- 96ε "83- 98ε .9 99 dSV ao WOIV0 69 ■ 9ε 00 ι 806 96-96ε "83-98ε .9 99 dSV ao WOIV
0 ■9ε 00 ι 1£1 ■1- W)9 -LZ- ε 'sfe- S9 s dSV vo im WOIV0 ■ 9ε 00 ι 1 £ 1 ■ 1- W) 9 -LZ- ε 'sfe- S9 s dSV vo im WOIV
N £Z τζ 00 ι L9L ■L - 89Ζ. '12 - 910'^- 9S g dSV N 0 61 WOIVN £ Z τζ 00 ι L9L L-89Ζ. '12-910 '^-9S g dSV N 0 61 WOIV
0 IZ 00 ι 0L£ ■1 - LZ9 '93- ん Ofr.Sfr- 9 9 V1V 0 6S6L WOIV0 IZ 00 ι 0L £ ■ 1-LZ9 '93-Ofr.Sfr- 9 9 V1V 0 6S6L WOIV
0 01 -ιε 00 ■ι 992 ε . "93- 9LI τν- V9 a V1V 0 8S6L WOIV0 01 -ιε 00 ■ ι 992 ε. "93- 9LI τν- V9 a V1V 0 8S6L WOIV
0 εζ. ■SZ 00 Ί 060 ー Ζ 5 "93- s V V ao Z.S6L WO丄 V0 εζ. ■ SZ 00 Ί 060 ー Ζ 5 "93- s V V ao Z.S6L WO 丄 V
0 93 -63 00 ■L 'τ- 986 ' - 188■ Lt-- g V1V vo 9 61 WOIV0 93 -63 00 L 'τ- 986'-188 Lt- g V1V vo 9 61 WOIV
N 39 'L 00 "L L69 •τ- θ ·8Ζ- cos■ ι - ½ g Vつ V N 3861 WOIVN 39 'L 00 "L L69 τ-θ 8Ζ- cos ■ ι-½ g V V N 3861 WOIV
0 91 -93 00 L 'ο - ρερ 'sz- εε ' ιν- 8 mi 0 IN01V0 91 -93 00 L 'ο-ρερ' sz- εε 'ιν- 8 mi 0 IN01V
0 It- ■LZ 00 ■ι 9 - 900 '62- 09Z■ - 9 g mi 0 βΐ WOIV0 It- ■ LZ 00 ■ ι 9-900 '62-09Z ■-9 g mi 0 βΐ WOIV
0 11 ■οε 00 ■|. Ό - .9L3 ε - 9Z.3 '6S- g mi zoo 3 61. WOIV0 11 ■ οε 00 ■ |. Ό-.9L3 ε-9Z.3 '6S- g mi zoo 3 61. WOIV
0 99 •LZ 00 ■ι εζ.6 •0- '6Ζ- 699 8ε- ε9 ■g mi L90 l£6l WOIV0 99 • LZ 00 ■ ι εζ.6 • 0- '6Ζ- 699 8ε- ε9 ■ g mi L90 l £ 6l WOIV
〇 LL ■οε 00 Ί 689 ■0 - i L 'οε- 6ん 9 '6S- 8 9 ao 0Σ61 WOiV〇 LL ■ οε 00 Ί 689 ■ 0-i L 'οε- 6 9' 6S- 8 9 ao 0Σ61 WOiV
0 98 '6Z 00 •ι οε9 Ί- 8 ·οε - 988 'Ofr- 9 g mi vo 626 L WOIV0 98 '6Z 00 • ι οε9 Ί-8 οε-988' Ofr- 9 g mi vo 626 L WOIV
N S8 00 ■L 306 'τ- S88 'οε— 963 Ofr- ΐ g mi N 836 L WOIVN S8 00 L 306 'τ- S88' οε— 963 Ofr- ΐ g mi N 836 L WOIV
0 6ε "9 00 •L ow) ·ε - LSZ ZV- Ζ5 9 v，v 0 LZ61 WOIV0 6ε "9 00 • L ow) · ε-LSZ ZV- Ζ5 9 v, v 0 LZ61 WOIV
〇 09 εε 00 'L ε½ .ε - ■ 12- fL£ IV- Ζ5 g V1V 0 926 L INOiV○ 09 εε 00 'L ε½ .ε-∎ 12- fL £ IV- Ζ5 g V1V 0 926 L INOiV
0 29 'εε 00 ζη - - 999 'εε- L9£ Ofr- ZS V1V ao 326 L N01V0 29 'εε 00 ζη--999' εε- L9 £ Ofr- ZS V1V ao 326 L N01V
0 ん ε.εε 00 ■1· 8S6 - 19 L 'ζ - SS6 Ofr - Ζ9 g V1V vo VZ61 INOIV0 ε.εε 00 1 / 8S6-19 L 'ζ-SS6 Ofr-Ζ9 g V1V vo VZ61 INOIV
N ½-εε 00 ,ι 6½ '9- QZZ ΙΖ- fr66 '6S - 39 g V1V N £Z6l WOIVN ½-εε 00, ι 6½ '9- QZZ ΙΖ- fr66' 6S-39 g V1V N £ Z6l WOIV
0 00 •ι 626 1£9 '63- 9 IS ' - 12 ΠΊ9 0 3261 WOIV0 00 • ι 626 1 £ 9 '63 -9 IS '-12 ΠΊ9 0 3261 WOIV
0 so ε 00 •ι 680 ·9 - L90 'οε - 0L Ofr- 19 g Π19 0 WOIV0 so ε 00 • ι 680 9-L90 'οε-0L Ofr- 19 g Π19 0 WOIV
0 00 ■L OL ·6- Ζ.86 82- 896 '9S- 19 9 ΠΊ9 330 036 L WOIV 0 00 LOL 6- Ζ.86 82- 896 '9S- 19 9 ΠΊ9 330 036 L WOIV
SSZ.l.0/.00Zdf/X3d 0Cr.S0/600Z O ATOM 1956 N 6LU B 57 - 45. 200 -28. 256 4. 314 1. 00 42. 37 NSSZ.l.0 / .00Zdf / X3d 0Cr.S0 / 600Z O ATOM 1956 N 6LU B 57-45. 200 -28. 256 4. 314 1. 00 42. 37 N
ATOM 1957 CA GLU B 57 - 45. 821 -27. 414 5. 327 1. 00 44. 68 CATOM 1957 CA GLU B 57-45. 821 -27. 414 5. 327 1. 00 44. 68 C
ATOM 1958 CB 6LU B 57 -47. 025 - 28. 132 5. 935 1. 00 47. 69 CATOM 1958 CB 6LU B 57 -47. 025-28. 132 5. 935 1. 00 47. 69 C
ATOM 1959 CG GLU B 57 - 48. 199一 27. 216 6. 189 1. 00 55. 23 CATOM 1959 CG GLU B 57-48. 199 One 27. 216 6. 189 1. 00 55. 23 C
ATOM 1960 CD GLU B 57 -48. 564 - 26. 401 4. 958 1. 00 58. 69 CATOM 1960 CD GLU B 57 -48. 564-26. 401 4. 958 1. 00 58. 69 C
ATOM 1961 0E1 GLU B 57 -49. 224 -26. 959 4. 054 1. 00 59. 62 0ATOM 1961 0E1 GLU B 57 -49. 224 -26. 959 4. 054 1. 00 59. 62 0
ATOM 1962 0E2 GLU B 57 - 48. 187一 25. 204 4. 896 1. 00 61. 14 0ATOM 1962 0E2 GLU B 57-48. 187 1 25. 204 4. 896 1. 00 61. 14 0
ATOM 1963 C GLU B 57 -44. 822 -27. 065 6. 427 1. 00 43. 37 CATOM 1963 C GLU B 57 -44. 822 -27. 065 6. 427 1. 00 43. 37 C
ATOM 1964 0 GLU B 57 -44. 195 -27. 951 7. 013 1. 00 44. 44 0ATOM 1964 0 GLU B 57 -44. 195 -27. 951 7. 013 1. 00 44. 44 0
ATOM 1965 N THR B 58 -44. 673 -25. 774 6. 700 1. 00 41. 63 NATOM 1965 N THR B 58 -44. 673 -25. 774 6. 700 1. 00 41. 63 N
ATOM 1966 CA THR B 58 -43. 855 -25. 323 7. 819 1. 00 40. 96 CATOM 1966 CA THR B 58 -43. 855 -25. 323 7. 819 1. 00 40. 96 C
ATOM 1967 ' CB THR B 58 -42. 916 -24. 165 7. 395 1. 00 40. 36 CATOM 1967 'CB THR B 58 -42. 916 -24. 165 7. 395 1. 00 40. 36 C
ATOM 1968 061 THR B 58 -43. 690 -23. 068 6. 896 1. 00 39. 82 0ATOM 1968 061 THR B 58 -43. 690 -23. 068 6. 896 1. 00 39. 82 0
ATOM 1969 CG2 THR B 58 -41. 954 - 24. 627 6. 307 1. 00 39. 86 CATOM 1969 CG2 THR B 58 -41. 954-24. 627 6. 307 1. 00 39. 86 C
ATOM 1970 C THR B 58 -44. 731 -24. 866 8. 989 1. 00 41. 58 CATOM 1970 C THR B 58 -44. 731 -24. 866 8. 989 1. 00 41. 58 C
ATOM 1971 0 THR B 58 -45. 860 -24. 423 8. 797 1. 00 40. 38 0ATOM 1971 0 THR B 58 -45. 860 -24. 423 8. 797 1. 00 40. 38 0
ATOM 1972 N GLU B 59 -44. 213 - 24. 992 10. 204 1. 00 41. 99 NATOM 1972 N GLU B 59 -44. 213-24. 992 10. 204 1. 00 41. 99 N
ATOM 1973 CA GLU B 59 -44. 874 -24. 422 11. 369 1. 00 43. 72 CATOM 1973 CA GLU B 59 -44. 874 -24. 422 11. 369 1. 00 43. 72 C
ATOM 1974 CB GLU B 59 -45. 235 -25. 528 12. 366 1. 00 46. 23 CATOM 1974 CB GLU B 59 -45. 235 -25. 528 12. 366 1. 00 46. 23 C
ATOM 1975 C6 GLU B 59 -44. 073 - 26. 456 12. 694 1. 00 49. 83 CATOM 1975 C6 GLU B 59 -44. 073-26. 456 12. 694 1. 00 49. 83 C
ATOM 1976 CD GLU B 59 -44. 298 - 27. 275 13. 953 1. 00 52. 13 CATOM 1976 CD GLU B 59 -44. 298-27. 275 13. 953 1. 00 52. 13 C
ATOM 1977 0E1 GLU B 59 -43. 325 - 27. 888 14. 439 1. 00 52. 94 0ATOM 1977 0E1 GLU B 59 -43. 325-27. 888 14. 439 1. 00 52. 94 0
ATOM 1978 0E2 GLU B 59 -45. 442 -27. 307 14'. 458 1. . 00 54. 84 0ATOM 1978 0E2 GLU B 59 -45. 442 -27. 307 14 '. 458 1.. 00 54. 84 0
ATOM 1979 C GLU B 59 - 43. 960 -23. 399 12. 042 1. 00 43. 71 CATOM 1979 C GLU B 59-43. 960 -23. 399 12. 042 1. 00 43. 71 C
ATOM 1980 0 GLU B 59 - 42. 748 -23. 599 12. 125 1. , 00 41. 81 0ATOM 1980 0 GLU B 59-42. 748 -23. 599 12. 125 1., 00 41. 81 0
ATOM 1981 N LYS B 60 -44. 546 -22. 307 12. 524 1. , 00 43. 32 NATOM 1981 N LYS B 60 -44. 546 -22. 307 12. 524 1., 00 43. 32 N
ATOM 1982 CA LYS B 60 -43. 794 -21. 282 13. 242 1. , 00 43. 10 CATOM 1982 CA LYS B 60 -43. 794 -21. 282 13. 242 1., 00 43. 10 C
ATOM 1983 CB LYS B 60 -44. 671 - 20. 055 13. 491 1. . 00 43. 12 CATOM 1983 CB LYS B 60 -44. 671-20. 055 13. 491 1.. 00 43. 12 C
ATOM 1984 CG LYS B 60 -44. 920 -19. 206 12. 259 1. , 00 44. 85 CATOM 1984 CG LYS B 60 -44. 920 -19. 206 12. 259 1., 00 44. 85 C
ATOM 1985 CD LYS B 60 -43. 614 -18. 683 1. . 00 45. 93 CATOM 1985 CD LYS B 60 -43. 614 -18. 683 1.. 00 45. 93 C
ATOM 1986 CE LYS B 60 -43. 868 -17. 546 10. 705 1. . 0ひ 44. 67 CATOM 1986 CE LYS B 60 -43. 868 -17. 546 10. 705 1. .0 H 44. 67 C
ATOM 1987 NZ LYS B 60 -45. 016 -17. 846 9. 814 1. . 00 45. 20 NATOM 1987 NZ LYS B 60 -45. 016 -17. 846 9. 814 1.. 00 45. 20 N
ATOM 1988 C LYS B 60 -43. 264 -21. 792 14. 576 1. . 00 42. 34 CATOM 1988 C LYS B 60 -43. 264 -21. 792 14. 576 1.. 00 42. 34 C
ATOM 1989 0 LYS B 60 -43. 956 -22. 503 15. 297 1. . 00 43. 31 0ATOM 1989 0 LYS B 60 -43. 956 -22. 503 15. 297 1.. 00 43. 31 0
ATOM 1990 N VAL B 61 - 42. 028 -21. 421 14. 894 1 , . 00 41. 83 NATOM 1990 N VAL B 61-42. 028 -21. 421 14. 894 1,. 00 41. 83 N
ATOM 1991 CA VAL B 61 -41. 404 -21. 777 16. 162 1 , . 00 40. 39 C ATOM 1992 CB VAL B 61 -40.526 - 23.049 16.021 1.00 41.48 CATOM 1991 CA VAL B 61 -41. 404 -21. 777 16. 162 1,. 00 40. 39 C ATOM 1992 CB VAL B 61 -40.526-23.049 16.021 1.00 41.48 C
ATOM 1993 CG1 VAL B 61 -39.854 - 23.373 17.344 1. 00 42.88 CATOM 1993 CG1 VAL B 61 -39.854-23.373 17.344 1. 00 42.88 C
ATOM 1994 CG2 VAL B 61 -41. 372 -24.219 15.574 1. 00 42.04 CATOM 1994 CG2 VAL B 61 -41. 372 -24.219 15.574 1. 00 42.04 C
ATOM 1995 C VAL B 61 -40.516 - 20.616 16.611 1. 00 39.54 CATOM 1995 C VAL B 61 -40.516-20.616 16.611 1. 00 39.54 C
ATOM 1996 0 VAL B 61 -39.819 -20.015 15.794 1. 00 40.07 0ATOM 1996 0 VAL B 61 -39.819 -20.015 15.794 1. 00 40.07 0
ATOM 1997 N THR B 62 - 40.544 - 20.295 17. 902 1. 00 38.10 NATOM 1997 N THR B 62-40.544-20.295 17. 902 1. 00 38.10 N
ATOM 1998 CA THR B 62 -39.626 -19.298 18. 444 1. 00 36. 07 CATOM 1998 CA THR B 62 -39.626 -19.298 18. 444 1. 00 36. 07 C
ATOM 1999 CB THR B 62 -40.248 -18.458 19. 579 1. 00 36.45 CATOM 1999 CB THR B 62 -40.248 -18.458 19. 579 1. 00 36.45 C
ATOM 2000 0G1 THR B 62 - 40.475 -19.299 20. 720 1. 00 38.26 0ATOM 2000 0G1 THR B 62-40.475 -19.299 20. 720 1.00 38.26 0
ATOM 2001 CG2 THR B 62 -41. 546 -17.819 19. 128 1. 00 33.49 CATOM 2001 CG2 THR B 62 -41. 546 -17.819 19. 128 1. 00 33.49 C
ATOM 2002 C THR B 62 - 38.420 -20.001 19. 036 1. 00 34.52 CATOM 2002 C THR B 62-38.420 -20.001 19. 036 1.00 34.52 C
ATOM 2003 0 THR B 62 -38.555 -20.907 19. 865 1. 00 32.54 0ATOM 2003 0 THR B 62 -38.555 -20.907 19. 865 1. 00 32.54 0
ATOM 2004 N ILE B 63 - 37. 239 -19.571 18. 612 1. 00 32. 07 • NATOM 2004 N ILE B 63-37. 239 -19.571 18. 612 1. 00 32. 07 • N
ATOM 2005 CA ILE B 63 - 36. 003 -20.110 19. 147 1. 00 30. 10 CATOM 2005 CA ILE B 63-36. 003 -20.110 19. 147 1. 00 30. 10 C
ATOM 2006 CB ILE B 63 -35. 183 -20.794 18. 046 1. 00 30. 42 CATOM 2006 CB ILE B 63 -35. 183 -20.794 18. 046 1. 00 30. 42 C
ATOM 2007 CG2 ILE B 63 - 36. 034 - 21.868 17. 358 1. 00 30. 92 CATOM 2007 CG2 ILE B 63-36. 034-21.868 17. 358 1. 00 30. 92 C
ATOM 2008 CG1 ILE B 63 -34. 741 -19.757 17. 009 1. 00 31. 40 CATOM 2008 CG1 ILE B 63 -34. 741 -19.757 17. 009 1. 00 31. 40 C
ATOM 2009 CD1 ILE B 63 -33. 738 -20.275 15. 992 1. 00 30. 19 CATOM 2009 CD1 ILE B 63 -33. 738 -20.275 15. 992 1. 00 30. 19 C
ATOM 2010 C ILE B 63 -35. 219 -18.943 19. 704 1. 00 30. 15 CATOM 2010 C ILE B 63 -35. 219 -18.943 19. 704 1. 00 30. 15 C
ATOM 2011 0 ILE B 63 -35. 578 -17.783 19. 484 1. ,00 28. 57 0ATOM 2011 0 ILE B 63 -35. 578 -17.783 19. 484 1., 00 28. 57 0
ATOM 2012 N GLU B 64 -34. 152 -19.245 20. 431 1. 00 31. 49 NATOM 2012 N GLU B 64 -34. 152 -19.245 20. 431 1. 00 31. 49 N
ATOM 2013 CA GLU B 64 -33. 242 -18.208 20. 892 1. ,00 31. 50 CATOM 2013 CA GLU B 64 -33. 242 -18.208 20. 892 1., 00 31. 50 C
ATOM 2014 CB GLU B 64 -32. 385 -18.743 22.041 1. .00 32. 54 CATOM 2014 CB GLU B 64 -32. 385 -18.743 22.041 1. .00 32. 54 C
ATOM 2015 CG GLU B 64 -31. 741 -17.653 22. 876 1. ,00 38. 27 CATOM 2015 CG GLU B 64 -31. 741 -17.653 22. 876 1., 00 38. 27 C
ATOM 2016 CD GLU B 64 - 32. 769 -16.721 23. 503 1. ,00 43. 26 CATOM 2016 CD GLU B 64-32. 769 -16.721 23. 503 1., 00 43. 26 C
ATOM 2017 0E1 GLU B 64 - 33. 763 -17.225 24. 086 1. .00 42. 75 0ATOM 2017 0E1 GLU B 64-33. 763 -17.225 24. 086 1. .00 42. 75 0
ATOM 2018 0E2 GLU B 64 - 32. 582 -15.485 23. 409 1. .00 45. 23 0ATOM 2018 0E2 GLU B 64-32. 582 -15.485 23. 409 1. .00 45. 23 0
ATOM 2019 C GLU B 64 -32. 354 -17.795 19. 719 1. .00 31. 17 CATOM 2019 C GLU B 64 -32. 354 -17.795 19. 719 1. .00 31. 17 C
ATOM 2020 0 GLU B 64 -31. 520 -18.579 19. 257 1, .00 31. 02 0ATOM 2020 0 GLU B 64 -31. 520 -18.579 19. 257 1, .00 31. 02 0
ATOM' 2021 N GLY B 65 -32. 547 -16.578 19. 221 1. .00 29. 21 NATOM '2021 N GLY B 65 -32. 547 -16.578 19. 221 1. .00 29. 21 N
ATOM 2022 CA GLY B 65 - 31. 685 -16.086 18. 163 1, .00 29. 60 CATOM 2022 CA GLY B 65-31. 685 -16.086 18. 163 1, .00 29. 60 C
ATOM 2023 C GLY B 65 -30. 399 -15.545 18. 764 1, .00 31. 01 CATOM 2023 C GLY B 65 -30. 399 -15.545 18. 764 1, .00 31. 01 C
ATOM 2024 0 GLY B 65 -30. 270 -15.470 19. 987 1, .00 30. 41 0ATOM 2024 0 GLY B 65 -30. 270 -15.470 19. 987 1, .00 30. 41 0
ATOM 2025 N TRP B 66 -29. 443 -15.164 17. 922 1, .00 31. 95 NATOM 2025 N TRP B 66 -29. 443 -15.164 17. 922 1, .00 31. 95 N
ATOM 2026 CA TRP B 66 - 28. 147 -14.719 18. 434 1 .00 31. ,44 CATOM 2026 CA TRP B 66-28. 147 -14.719 18. 434 1 .00 31., 44 C
ATOM 2027 CB TRP B 66 -27. 180 -14.392 17. 286 1, .00 26. ,39 C ATOM 2028 CG TRP 6 66 -27.583 -13.220 16.465 1.00 25.69 CATOM 2027 CB TRP B 66 -27. 180 -14.392 17. 286 1, .00 26., 39 C ATOM 2028 CG TRP 6 66 -27.583 -13.220 16.465 1.00 25.69 C
ATOM 2029 CD2 TRP B 66 -27.085 -11. 878 16.573 1. 00 25.88 CATOM 2029 CD2 TRP B 66 -27.085 -11. 878 16.573 1. 00 25.88 C
ATOM 2030 CE2 TRP B 66 -27.780 -11. 100 15.627 1. 00 26.50 CATOM 2030 CE2 TRP B 66 -27.780 -11. 100 15.627 1. 00 26.50 C
ATOM 2031 CE3 TRP B 66 - 26.122 -11. 260 17.379 1. 00 25.88 CATOM 2031 CE3 TRP B 66-26.122 -11. 260 17.379 1. 00 25.88 C
ATOM 2032 CD1 TRP B 66 - 28.525 -13.200 15.483 1. 00 24.13 CATOM 2032 CD1 TRP B 66-28.525 -13.200 15.483 1.00 24.13 C
ATOM 2033 NE1 TRP B 66 -28.651 -11. 933 14.974 1. 00 24.69 NATOM 2033 NE1 TRP B 66 -28.651 -11. 933 14.974 1. 00 24.69 N
ATOM 2034 CZ2 TRP B 66 - 27, 547 -9.733 15.462 1. 00 27.89 CATOM 2034 CZ2 TRP B 66-27, 547 -9.733 15.462 1. 00 27.89 C
ATOM 2035 CZ3 TRP B 66 -25.891 - 9.902 17.215 1. 00 27.89 CATOM 2035 CZ3 TRP B 66 -25.891-9.902 17.215 1.00 27.89 C
ATOM 2036 CH2 TRP B 66 -26.601 -9.154 16.264 1. 00 29.65 C ATOM 2036 CH2 TRP B 66 -26.601 -9.154 16.264 1. 00 29.65 C
00  00
ATOM 2037 C TRP B 66 - 28.343 -13.497 19.317 1. 00 31.41 C o  ATOM 2037 C TRP B 66-28.343 -13.497 19.317 1. 00 31.41 Co
ATOM 2038 0 TRP B 66 -27.668 -13.350 20.336 1. 00 34.65 0 ATOM 2038 0 TRP B 66 -27.668 -13.350 20.336 1. 00 34.65 0
ATOM 2039 N ASN B 67 -29.282 -12. 635 18.940 1. 00 30.80 NATOM 2039 N ASN B 67 -29.282 -12. 635 18.940 1. 00 30.80 N
ATOM 2040 CA ASN B 67 -29.596 -11. 456 19.744 1. 00 32.31 . CATOM 2040 CA ASN B 67 -29.596 -11. 456 19.744 1. 00 32.31. C
ATOM 2041 CB ASN B 67 -29.440 -10. 190 18.896 1. 00 32.90 GATOM 2041 CB ASN B 67 -29.440 -10. 190 18.896 1. 00 32.90 G
ATOM 2042 CG ASN B 67 -30.327 -10. 200 .17.671 1. 00 34.82 CATOM 2042 CG ASN B 67 -30.327 -10. 200 .17.671 1. 00 34.82 C
ATOM 2043 0D1 ASN B 67 -11. 132 17.463 1. 00 35.60 0ATOM 2043 0D1 ASN B 67 -11. 132 17.463 1. 00 35.60 0
ATOM 2044 ND2 ASN B 67 -30.213 - 9. 165 16.846 1. 00 36.33 NATOM 2044 ND2 ASN B 67 -30.213-9. 165 16.846 1. 00 36.33 N
ATOM 2045 C ASN B 67 -31.005 -11. 495 20.354 1. 00 32.08 CATOM 2045 C ASN B 67 -31.005 -11. 495 20.354 1. 00 32.08 C
ATOM 2046 0 ASN B 67 -31.750 -10. 516 20.287 1. 00. 31.12 0ATOM 2046 0 ASN B 67 -31.750 -10. 516 20.287 1. 00. 31.12 0
ATOM 2047 N GLY B 68 -31.364 -12. 624 20.956 1. .00 32.32 NATOM 2047 N GLY B 68 -31.364 -12. 624 20.956 1. .00 32.32 N
ATOM 2048 CA GLY B 68 -32.683 -12. 744 21.554 1. ,00 32.35 CATOM 2048 CA GLY B 68 -32.683 -12. 744 21.554 1., 00 32.35 C
ATOM 2049 C GLY B 68 -33.674 - 13. 562 20.735 1. ,00 32.30 GATOM 2049 C GLY B 68 -33.674-13. 562 20.735 1., 00 32.30 G
ATOM 2050 0 GLY B 68 -33.338 -14. 068 19.661 1. .00 31.76 0ATOM 2050 0 GLY B 68 -33.338 -14. 068 19.661 1. .00 31.76 0
ATOM 2051 N PRO B 69 -34.918 -13. 702 21.224 1. ,00 31.69 NATOM 2051 N PRO B 69 -34.918 -13. 702 21.224 1., 00 31.69 N
ATOM 2052 CD PRO B 69 - 35.399 -13. 078 22.467 1. .00 31.14 CATOM 2052 CD PRO B 69-35.399 -13. 078 22.467 1. .00 31.14 C
ATOM 2053 CA PRO B 69 一 35.941 -14. 569 20.631 1. ,00 29.12 CATOM 2053 CA PRO B 69 1 35.941 -14. 569 20.631 1., 00 29.12 C
ATOM 2054 CB PRO B 69 -37.109 -14. 467 21.609 1. .00 30.67 CATOM 2054 CB PRO B 69 -37.109 -14. 467 21.609 1. .00 30.67 C
ATOM 2055 CG PRO B 69 -36.499 -13. 992 22.883 1. .00 31.76 CATOM 2055 CG PRO B 69 -36.499 -13. 992 22.883 1. .00 31.76 C
ATOM 2056 C PRO B 69 -36.345 -14. 162 19.215 1. .00 27.29 CATOM 2056 C PRO B 69 -36.345 -14. 162 19.215 1. .00 27.29 C
ATOM 2057 0 PRO B 69 -36.500 -12. 985 18.907 1, .00 27.97 0ATOM 2057 0 PRO B 69 -36.500 -12. 985 18.907 1, .00 27.97 0
ATOM 2058 N VAL B 70 -36.513 - 15. 154 18.356 1, .00 26.98 NATOM 2058 N VAL B 70 -36.513-15. 154 18.356 1, .00 26.98 N
ATOM 2059 CA VAL B 70 -36.945 -14. 912 16.993 1, .00 26.49 CATOM 2059 CA VAL B 70 -36.945 -14. 912 16.993 1, .00 26.49 C
ATOM 2060 CB VAL B 70 -35.737 -14. 783 16.026 1, .00 25.40 CATOM 2060 CB VAL B 70 -35.737 -14. 783 16.026 1, .00 25.40 C
ATOM 2061 CG1 VAL B 70 - 34.901 -16. 051 16.056 1 .00 24.06 CATOM 2061 CG1 VAL B 70-34.901 -16. 051 16.056 1 .00 24.06 C
ATOM 2062 C62 VAL B 70 -36.226 -14. 495 14.619 1, .00 23.57 CATOM 2062 C62 VAL B 70 -36.226 -14. 495 14.619 1, .00 23.57 C
ATOM 2063 C VAL B 70 一 37.819 -16. 067 16.552 1 .00 27.86 G ATOM 2064 0 VAL B 70 -37.575 -17.215 16.919 1.00 30.95 0ATOM 2063 C VAL B 70 1 37.819 -16. 067 16.552 1 .00 27.86 G ATOM 2064 0 VAL B 70 -37.575 -17.215 16.919 1.00 30.95 0
ATOM 2065 N GLU B 71 -38.848 -15.752 -15.779 1. 00 29.23 NATOM 2065 N GLU B 71 -38.848 -15.752 -15.779 1. 00 29.23 N
ATOM 2066 CA GLU B 71 - 39.744 - 6.762 15.246 1. 00 31.34 CATOM 2066 CA GLU B 71-39.744-6.762 15.246 1. 00 31.34 C
ATOM 2067 CB GLU B 71 -41.164 -16.195 15.114 1. 00 31.35 CATOM 2067 CB GLU B 71 -41.164 -16.195 15.114 1. 00 31.35 C
ATOM 2068 CG GLU B 71 -42.187 -17.222 14.649 1. 00 34.85 CATOM 2068 CG GLU B 71 -42.187 -17.222 14.649 1. 00 34.85 C
ATOM 2069 CD GLU B 71 - 43.615 -16.702 14.702 1. 00 35.30 CATOM 2069 CD GLU B 71-43.615 -16.702 14.702 1.00 35.30 C
ATOM 2070 0E1 GLU B 71 -44.284 -16.914 15.736 1. 00 35.01 0ATOM 2070 0E1 GLU B 71 -44.284 -16.914 15.736 1.00 35.01 0
ATOM 2071 0E2 GLU B 71 - 44.064 -16.089 13.710 1. 00 33.95 0ATOM 2071 0E2 GLU B 71-44.064 -16.089 13.710 1.00 33.95 0
ATOM 2072 C GLU B 71 -39.246 -17.233 13. 883 1. 00 31.00 CATOM 2072 C GLU B 71 -39.246 -17.233 13. 883 1.00 31.00 C
ATOM 2073 0 GLU B 71 -38.946 -16.424 13.007 1. 00 30.75 0ATOM 2073 0 GLU B 71 -38.946 -16.424 13.007 1. 00 30.75 0
ATOM 2074 N ILE B 72 - 39.164 -18.547 13. 714 1. 00 30.97 NATOM 2074 N ILE B 72-39.164 -18.547 13. 714 1. 00 30.97 N
ATOM 2075 CA ILE B 72 -38.709 -19.133 12. 458 1. 00 32.19 CATOM 2075 CA ILE B 72 -38.709 -19.133 12. 458 1. 00 32.19 C
ATOM 2076 CB ILE B 72 -37.342 -19.823 12. 643 1. 00 29.10 CATOM 2076 CB ILE B 72 -37.342 -19.823 12. 643 1. 00 29.10 C
ATOM 2077 CG2 ILE B 72 -36.328 -18.815 13. 167 1. 00 27.70 CATOM 2077 CG2 ILE B 72 -36.328 -18.815 13. 167 1. 00 27.70 C
ATOM 2078 CG1 ILE B 72 -37.477 -20.995 13. 621 1. .00 27.23 CATOM 2078 CG1 ILE B 72 -37.477 -20.995 13. 621 1. .00 27.23 C
ATOM 2079 CD1 ILE B 72 -36.312 -21.965 13. 586 1. 00 24.66 CATOM 2079 CD1 ILE B 72 -36.312 -21.965 13. 586 1. 00 24.66 C
ATOM 2080 C ILE B 72 -39.713 -20.160 11. 928 1. .00 32.57 CATOM 2080 C ILE B 72 -39.713 -20.160 11. 928 1. .00 32.57 C
ATOM 2081 0 ILE B 72 -40.595 -20.611 12. 662 1. .00 32.26 0ATOM 2081 0 ILE B 72 -40.595 -20.611 12. 662 1. .00 32.26 0
ATOM 2082 N ASP B 73 -39.573 -20.518 10. 652 1. ,00. 33.66 NATOM 2082 N ASP B 73 -39.573 -20.518 10. 652 1., 00. 33.66 N
ATOM 2083 CA ASP B 73 - 40.371 - 21.587 10. 044 1. ,00 34.55 CATOM 2083 CA ASP B 73-40.371-21.587 10. 044 1., 00 34.55 C
ATOM 2084 CB ASP B 73 -40.763 -21.220 8. 615 1. .00 36.41 CATOM 2084 CB ASP B 73 -40.763 -21.220 8.615 1. .00 36.41 C
ATOM 2085 CG ASP B 73 - 41.430 -19.868 8. 524 1. .00 41.18 CATOM 2085 CG ASP B 73-41.430 -19.868 8. 524 1. .00 41.18 C
ATOM 2086 0D1 ASP B 73 -40.792 -18.935 7. 983 1. .00 43.47 0ATOM 2086 0D1 ASP B 73 -40.792 -18.935 7. 983 1. .00 43.47 0
ATOM 2087 0D2 ASP B 73 - 42.586 -19.735 8. 992 1, .00 42.58 0ATOM 2087 0D2 ASP B 73-42.586 -19.735 8. 992 1, .00 42.58 0
ATOM 2088 C ASP B 73 -39.591 -22.893 10. 016 1, .00 34.44 CATOM 2088 C ASP B 73 -39.591 -22.893 10. 016 1, .00 34.44 C
ATOM 2089 0 ASP B 73 -38.452 -22.936 9. 564 1. .00 34.49 0ATOM 2089 0 ASP B 73 -38.452 -22.936 9. 564 1. .00 34.49 0
ATOM 2090 N GLN B 74 - 40.213 -23.961 10. 494 1, .00 35.35 NATOM 2090 N GLN B 74-40.213 -23.961 10. 494 1, .00 35.35 N
ATOM 2091 CA GLN B 74 -39.559 -25.260 10. 543 1, .00 37.08 CATOM 2091 CA GLN B 74 -39.559 -25.260 10. 543 1, .00 37.08 C
ATOM 2092 CB GLN B 74 -39.352 - 25.692 11. 995 1, .00 36.29 CATOM 2092 CB GLN B 74 -39.352-25.692 11. 995 1, .00 36.29 C
ATOM 2093 CG GLN B 74 -38.288 - 24.889 12. 716 1, .00 38.14 CATOM 2093 CG GLN B 74 -38.288-24.889 12. 716 1, .00 38.14 C
ATOM 2094 CD GLN B 74 -36.887 -25.152 12. 174 1 .00 38.45 CATOM 2094 CD GLN B 74 -36.887 -25.152 12. 174 1 .00 38.45 C
ATOM 2095 0E1 GLN B 74 -36.192 -26.054 12. 639 1, .00 36.35 0ATOM 2095 0E1 GLN B 74 -36.192 -26.054 12. 639 1, .00 36.35 0
ATOM 2096 NE2 GLN B 74 - 36.470 -24.360 11. 190 1 .00 36.24 NATOM 2096 NE2 GLN B 74-36.470 -24.360 11. 190 1 .00 36.24 N
ATOM 2097 C GLN B 74 -40.357 -26.324 9. 807 1 .00 38.72 CATOM 2097 C GLN B 74 -40.357 -26.324 9. 807 1 .00 38.72 C
ATOM 2098 0 GLN B 74 -41.580 - 26.223 9. 666 1 .00 37.83 0ATOM 2098 0 GLN B 74 -41.580-26.223 9.666 1 .00 37.83 0
ATOM 2099 N ILE B 75 -39.650 -27.341 9. 328 1 .00 39.30 N 18 ATOM 2099 N ILE B 75 -39.650 -27.341 9. 328 1 .00 39.30 N 18
N LZ■½ 001 ι L99 ' 060 ' ε - 198 Ί^- 6 8 Ski ZN 9ε 13 WO丄 VN LZ ½ 00 1 ι L99 '060' ε-198 Ί ^-6 8 Ski ZN 9ε 13 WO 丄 V
0 96 '2S 00■ L L89 ΈΙ ZLL ·9ε- 8S6 -Ζ^- 6L g s人 1 30 W01V0 96 '2S 00 ■ L L89 ΈΙ ZLL 9ε-8S6 -Ζ ^-6L g s 1 30 W01V
0 6ε OS 001 L L62 'ΖΪ 6Z.fr ·9ε- τν ' - 6ん 9 Ski GO εει.3 IN01V0 6ε OS 00 1 L L62 'ΖΪ 6Z.fr 9ε- τν'-6 9 Ski GO εει.3 IN01V
0 00' ι 62■ L 1 S8L 9ε- ζζ τν- 6Z. Q s人， 90 ζζιζ WO丄 V0 00 'ι 62 ■ L 1 S8L 9ε- ζζ τν-6 Z. Q s people, 90 ζζιζ WO 丄 V
0 38 ~n 00■ ι C88 '6 066 '9ε- QL6 ' - 6 Q SAT 80 1£IZ W01V0 38 ~ n 00 ι C88 '6 066' 9ε- QL6 '-6 Q SAT 80 1 £ IZ W01V
0 u - ^ οο■ ι 29fr '6 ^εο ' ε- 6L g s人， VO 0£lZ WOiV0 u-^ οο ■ ι 29fr '6 ^ εο' ε- 6L gs people, VO 0 £ lZ WOiV
N 98 00 ι 6 '6 2^9 "98- 009017- 6L SAT N 62 L3 W01VN 98 00 ι 6 '6 2 ^ 9 "98- 009017- 6L SAT N 62 L3 W01V
0 00■ L ん 9S OL 9LZ.-8C- ζ,εο Ofr- 8ん g Ski 0 SZIZ W01V0 00 L 9S OL 9LZ.-8C- ζ, εο Ofr-8 g Ski 0 SZIZ W01V
0 S8 -n 00 L 99C 01 ο½ ζ.ε- OZL '6S - 8L g S人 Ί 0 LZ\Z WOIV0 S8 -n 00 L 99C 01 ο½ ζ.ε- OZL '6S-8L g S people Ί 0 LZ \ Z WOIV
N 69 S 00 L 9LZ "91. t-οε '9ε- Ζ.96 ·9ε- 8Z. g s人つ ZN IN01VN 69 S 00 L 9LZ "91.t-οε '9ε-Ζ.96 9ε-8Z.g s per person ZN IN01V
0 6 ε 00 L LLl 'SL 88 L "98- £9 'L - 8Z. Q s人， 30 S313 WOIV0 6 ε 00 L LLl 'SL 88 L "98- £ 9' L-8Z. Q s people, 30 S313 WOIV
0 83 Έ9 00 L 906 -ει 86ε '5ε- 99Ζ. LZ- SL a s人， ao •vzvi WOIV0 83 Έ9 00 L 906 -ει 86ε '5ε- 99Ζ. LZ- SL a s people, ao • vzvi WOIV
0 03 LS 00 Ί- 696 'ΖΙ 9 1. ·9ε- 869 '8ε- 8Z. g S人 Ί 90 £ZiZ WOIV0 03 LS 00 Ί-696 'ΖΙ 9 1. 9ε-869' 8ε-8Z.g S people Ί 90 £ ZiZ WOIV
0 00 L Z60 ?1· 03 L -ζ.ε- 996 ζ. - 8ん S人 Ί ao ZIYI WOIV0 00 L Z60? 1 · 03 L -ζ.ε- 996 ζ.-8 N S Ί ao ZIYI WOIV
0 ^6 ^ 00 Ί 909 'OL sw) ' ε- W£ 8ε- 8 Q s人つ vo YlYl WO丄 V0 ^ 6 ^ 00 Ί 909 'OL sw)' ε- W £ 8ε-8 Q s per person vo YlYl WO 丄 V
N 00 L 89 L OL 99 "9ε- 6ε ι '8ε - 8Z. Q SAl N 0313 WOIVN 00 L 89 L OL 99 "9ε- 6ε ι '8ε-8Z-Q SAl N 0313 WOIV
0 86 wn 00 ■L 0ん 6 'ん LZ.L ·9ε- βε- LL 9 AID 0 6U3 WOIV0 86 w n 00 L 0 6 L LZ.L 9ε- βε- LL 9 AID 0 6U3 WOIV
0 Z0 00 . 698 '8 ί^ε 'SS- οει ·8ε- LL 9人，9 0 SllZ WOIV0 Z0 00 .698 '8 ί ^ ε' SS- οει 8ε- LL 9 people, 9 0 SllZ WOIV
0 00 L fr½ '8 W8 εε- SS6 τ.ε- LL 9人， 9 VO LViZ WOIV0 00 L fr½ '8 W8 εε- SS6 τ.ε- LL 9 people, 9 VO LViZ WOIV
N Lz -n 00 ■ι 66 6 t-66 "28- 009 '88- LL g人 9 N iiZ WOIVN Lz -n 00 ■ ι 66 6 t-66 "28- 009 '88-LL g people 9 N iiZ WOIV
0 εε·εΐ7 00 L 0Z.0 6 w>8 εε- 999 Ofr - 9L g SAl 0 9LL3 WOIV0 εε · εΐ 7 00 L 0Z.0 6 w> 8 εε-999 Ofr-9L g SAl 0 9LL3 WOIV
0 00 Ί ·6 966 WZ£- ΖΖ6 6ε- 9L g SAl 0 llZ WOIV0 00 Ί 6 966 W Z £-ΖΖ6 6ε-9 L g SAl 0 llZ WOIV
N It- '29 00 ,ί 228 "9 L ZL9 ·οε - 690 ' - 9L s S人， ZN IIZ IN01VN It- '29 00, ί 228 "9 L ZL9 · οε-690 '-9L s S, ZN IIZ IN01V
0 6ん 'ZS 00 L 08fr ' I . L69 'οε- SZL Ζ - 9L g SAl 30 WOIV0 6 'ZS 00 L 08fr' I. L69 'οε- SZL Ζ-9L g SAl 30 WOIV
0 08 IS 00 "1 Z5£'Zl βεο ' ιε- 09L■ YV- 9L a S人， ao z WOIV0 08 IS 00 "1 Z5 £ 'Zl βεο' ιε- 09L ■ YV- 9L a S person, ao z WOIV
〇 00 ■L 09031 99 " ιε- 019'21τ- 9ん 8 SAl 90 O Z WOIV○ 00 ■ L 09031 99 "ιε- 019'21τ-9 9 SAl 90 O Z WOIV
0 んん 00 Ί εεζ · " ρι ε- S8ん■ Lfr- 9L 9 S人， ao 6012 WOIV0 00 00 ε εεζ · ρι ε- S8 ■ Lfr-9L 9 S people, ao 6012 WOIV
0 00 ■L 6S9 ΌΙ 9L6.LS- ε09 Ofr - 9L 8 SAl vo 80 L2 WOIV0 00 L 6S9 ΌΙ 9L6.LS- ε09 Ofr-9L 8 SAl vo 80 L2 WOIV
N 00 09L ·6 L2L 'οε - Z6L Ofr- 9L g S人， N LOIZ WOIVN 00 09L 6L2L 'οε-Z6L Ofr- 9L g S, N LOIZ WOIV
0 08 ' 00 'L 0L8 OL 09^ '62- 382 ·6ε - L 9 311 0 9013 WOIV0 08 '00' L 0L8 OL 09 ^ '62-382 6ε-L 9 311 0 9013 WOIV
0 00 Ί ん 88 ·6 0S9 '62- εζ,ο Ofr - 5L g 311 0 90 LZ WOIV0 00 Ί 88 88 6S9 '62-εζ, ο Ofr-5L g 311 0 90 LZ WOIV
0 68 Ό 00 'L SOL '9 92ε "83- 60S '6S- SZ. g 311 ιαο OIZ WOIV0 68 Ό 00 'L SOL' 9 92ε "83-60S '6S- SZ.g 311 ιαο OIZ WOIV
〇 εん ·8ε 00 ■L W9 6fr6 -LZ- S68 '6 - 2L a 311 IQO ZOIZ WOIV〇 ε N 8ε 00 L W9 6fr6 -LZ- S68 '6-2L a 311 IQO ZOIZ WOIV
0 οι τν 00 890■ 6οε -οε- ζοε ofr- SL g 311 ZOO 3012 WOIV0 οι τν 00 890 ■ 6οε -οε- ζοε ofr- SL g 311 ZOO 3012 WOIV
0 ει 00 ■ι 90S 'ん 110 '62- 0L9 ·6ε- QL g Ξ1Ι ao 10LZ WOIV0 ει 00 ■ ι 90S '110 '62-0L9 6ε- QL g Ξ1Ι ao 10LZ WOIV
0 00 888 '8 199.82 - 68Ζ Ofr— L Q 311 vo 00 WOIV 0 00 888 '8 199.82-68Ζ Ofr— L Q 311 vo 00 WOIV
SS.l.0/Z,00idf/X3d 0CZ.S0/600Z ΟΛ\ ATOM 2136 C LYS B 79 -41.943 -37.207 7.943 1.00 42.26 CSS.l.0 / Z, 00idf / X3d 0CZ.S0 / 600Z ΟΛ \ ATOM 2136 C LYS B 79 -41.943 -37.207 7.943 1.00 42.26 C
ATOM 2137 0 LYS B 79 -43.007 -37.277 7.319 1. 00 41.27 0ATOM 2137 0 LYS B 79 -43.007 -37.277 7.319 1. 00 41.27 0
ATOM 2138 N ILE B 80 -40.748 - 37.268 7.358 1. 00 38.92 NATOM 2138 N ILE B 80 -40.748-37.268 7.358 1. 00 38.92 N
ATOM 2139 CA ILE B 80 -40.587 -37.630 5.952 1. 00 35.77 CATOM 2139 CA ILE B 80 -40.587 -37.630 5.952 1. 00 35.77 C
ATOM 2140 GB ILE B 80 -39.856 -36.517 5.170 1. 00 35.07 CATOM 2140 GB ILE B 80 -39.856 -36.517 5.170 1. 00 35.07 C
ATOM 2141 CG2 ILE B 80 -39.462 -37.012 3.784 1. 00 31.39 CATOM 2141 CG2 ILE B 80 -39.462 -37.012 3.784 1. 00 31.39 C
ATOM 2142 CG1 ILE B 80 -40.754 -35.280 5.085 1. 00 32.96 CATOM 2142 CG1 ILE B 80 -40.754 -35.280 5.085 1. 00 32.96 C
ATOM 2143 . CD1 ILE B 80 -40.093 -34.101 4.435 1. 00 31.60 CATOM 2143 .CD1 ILE B 80 -40.093 -34.101 4.435 1. 00 31.60 C
ATOM 2144 C ILE B 80 -39.791 -38.924 5.831 1. 00 35.31 CATOM 2144 C ILE B 80 -39.791 -38.924 5.831 1. 00 35.31 C
ATOM 2145 0 ILE B 80 -38.901 -39.196 6.634 1. 00 35.01 0ATOM 2145 0 ILE B 80 -38.901 -39.196 6.634 1. 00 35.01 0
ATOM 2146 N THR B 81 -40.122 - 39.728 4.831 1. 00 35.04 NATOM 2146 N THR B 81 -40.122-39.728 4.831 1. 00 35.04 N
ATOM 2147 'CA THR B 81 -39.444 -40.999 4.631 1. 00 35.43 CATOM 2147 'CA THR B 81 -39.444 -40.999 4.631 1.00 35.43 C
ATOM 2148 CB THR B 81 -40. 362 -42.181 4.987 1. 00 36.39 CATOM 2148 CB THR B 81 -40. 362 -42.181 4.987 1. 00 36.39 C
ATOM 2149 061 THR B 81 -40. 660 -42.146 6.388 1. 00 37.15 0ATOM 2149 061 THR B 81 -40. 660 -42.146 6.388 1. 00 37.15 0
ATOM 2150 CG2 THR B 81 -39. 680 -43.509 4.649 1. 00 37.25 CATOM 2150 CG2 THR B 81 -39. 680 -43.509 4.649 1. 00 37.25 C
ATOM 2151 C THR B 81 -38. 997 - 41.154 3.187 1. 00 34.94 CATOM 2151 C THR B 81 -38. 997-41.154 3.187 1. 00 34.94 C
ATOM 2152 0 THR B 81 -39. 794 -40.998 2.264 1. 00 36.72 0ATOM 2152 0 THR B 81 -39. 794 -40.998 2.264 1. 00 36.72 0
ATOM 2153 N VAL B 82 -37. 721 -41.458 2.988 1. 00 32.59 NATOM 2153 N VAL B 82 -37. 721 -41.458 2.988 1. 00 32.59 N
ATOM 2154 CA VAL B 82 - 37, 220 1.643 1. 00 31.87 CATOM 2154 CA VAL B 82-37, 220 1.643 1. 00 31.87 C
ATOM 2155 CB VAL B 82 -35. 749 1.495 1. ,00 32.26 CATOM 2155 CB VAL B 82 -35. 749 1.495 1., 00 32.26 C
ATOM 2156 CG1 VAL B 82 -34. 835 -42.093 2.351 1. ,00 32.83 CATOM 2156 CG1 VAL B 82 -34. 835 -42.093 2.351 1., 00 32.83 C
ATOM 2157 GG2 VAL B 82 -35. 327 0.038 1. .00 31.89 CATOM 2157 GG2 VAL B 82 -35. 327 0.038 1. .00 31.89 C
ATOM 2158 C VAL B 82 -37. 324 -43.187 ί.361 1. .00 30.55 CATOM 2158 C VAL B 82 -37. 324 -43.187 ί.361 1. .00 30.55 C
ATOM 2159 0 VAL B 82 -37. 056 -44.012 2.231 1. ,00 31.05 0ATOM 2159 0 VAL B 82 -37. 056 -44.012 2.231 1., 00 31.05 0
ATOM 2160 N VAL B 83 -37. 744 -43.533 0.149 1. ,00 29.95 NATOM 2160 N VAL B 83 -37. 744 -43.533 0.149 1., 00 29.95 N
ATOM 2161 CA VAL B 83 - 38. 042 -44.921 -0.179 1. .00 28.85 CATOM 2161 CA VAL B 83-38. 042 -44.921 -0.179 1. .00 28.85 C
ATOM 2162 CB VAL B 83 -39. 562 -45.137 - 0.330 1. .00 28.66 CATOM 2162 CB VAL B 83 -39. 562 -45.137-0.330 1. .00 28.66 C
ATOM 2163 CG1 VAL B 83 -39. 854 -46.604 -0.596 1, .00 29.23 CATOM 2163 CG1 VAL B 83 -39. 854 -46.604 -0.596 1, .00 29.23 C
ATOM 2164 CG2 VAL B 83 -40. 279 -44.669 0.931 1. .00 26.26 CATOM 2164 CG2 VAL B 83 -40. 279 -44.669 0.931 1. .00 26.26 C
ATOM 2165 G VAL B 83 -37. 356 -45.342 - 1■ 467 1, .00 28.53 CATOM 2165 G VAL B 83 -37. 356 -45.342-1 467 1, .00 28.53 C
ATOM 2166 0 VAL B 83 - 37. 971 - 45.357 -2.530 1. .00 29.31 0ATOM 2166 0 VAL B 83-37. 971-45.357 -2.530 1. .00 29.31 0
ATOM 2167 N PRO B 84 -36. 060 -45.677 -1.386 1, .00 27.87 NATOM 2167 N PRO B 84 -36. 060 -45.677 -1.386 1, .00 27.87 N
ATOM 2168 CD PRO B 84 -35. 217 - 45.566 - 0.179 1, .00 27.24 CATOM 2168 CD PRO B 84 -35. 217-45.566-0.179 1, .00 27.24 C
ATOM 2169 CA PRO B 84 - 35. 296 - 46.128 -2.550 1 .00 27.40 CATOM 2169 CA PRO B 84-35. 296-46.128 -2.550 1 .00 27.40 C
ATOM 2170 CB PRO B 84 -33. 848 -46.010 -2.091 1. .00 26.56 CATOM 2170 CB PRO B 84 -33. 848 -46.010 -2.091 1. .00 26.56 C
ATOM 2171 C6 PRO B 84 -33. 922 -46.187 -0.598 1 .00 24.20 C ATOM 2172 C PRO B 84 -35.659 -47.557 - 2.927 1.00 28.63 CATOM 2171 C6 PRO B 84 -33. 922 -46.187 -0.598 1 .00 24.20 C ATOM 2172 C PRO B 84 -35.659 -47.557-2.927 1.00 28.63 C
ATOM 2173 0 PRO B 84 - 35. 702 -48.433 - 2.066 1. 00 28.04 0ATOM 2173 0 PRO B 84-35. 702 -48.433-2.066 1. 00 28.04 0
ATOM 2174 N ILE B 85 -35. 915 -47.785 -4.213 1. 00 28.16 NATOM 2174 N ILE B 85 -35. 915 -47.785 -4.213 1. 00 28.16 N
ATOM 2175 CA ILE B 85 - 36. 172 - 49.127 - 4.721 1. 00 29.20 CATOM 2175 CA ILE B 85-36. 172-49.127-4.721 1. 00 29.20 C
ATOM 2176 CB ILE B 85 -37. 136 -49.087 -5.926 1. 00 26.50 CATOM 2176 CB ILE B 85 -37. 136 -49.087 -5.926 1. 00 26.50 C
ATOM 2177 CG2 ILE B 85 一 37. 446 -50.495 - 6.387 1. 00 24.30 CATOM 2177 CG2 ILE B 85 1 37. 446 -50.495-6.387 1. 00 24.30 C
ATOM 2178 CG1 ILE B 85 -38. 423 -48.359 -5.542 1. 00 26.10 CATOM 2178 CG1 ILE B 85 -38. 423 -48.359 -5.542 1. 00 26.10 C
ATOM 2179 CD1 ILE B 85 -39. 458 - 48.277 - 6.663 1. 00 23.76 CATOM 2179 CD1 ILE B 85 -39. 458-48.277-6.663 1. 00 23.76 C
ATOM 2180 C ILE B 85 - 34, 867 - 49.788 - 5.169 1. 00 30.78 CATOM 2180 C ILE B 85-34, 867-49.788-5.169 1. 00 30.78 C
ATO 2181 0 ILE B 85 -34.191 -49.284 - 6.067 1. 00 32.64 0ATO 2181 0 ILE B 85 -34.191 -49.284-6.067 1.00 32.64 0
ATOM 2182 N LEU B 86 -34.523 - 50.917 -4.557 1. 00 31.25 NATOM 2182 N LEU B 86 -34.523-50.917 -4.557 1. 00 31.25 N
ATOM 2183 CA LEU B 86 -33.280 -51. 622 - 4.878 1. 00 32.98 CATOM 2183 CA LEU B 86 -33.280 -51.622-4.878 1.00 32.98 C
ATOM 2184 CB LEU B 86 -33.064 -52. 780 -3. 904 1. 00 31.87 CATOM 2184 CB LEU B 86 -33.064 -52.780 -3.904 1.00 31.87 C
ATOM 2185 C6 LEU B 86 - 33. 065 -52. 411 -2. 424 1. 00 32.81 CATOM 2185 C6 LEU B 86-33. 065 -52. 411 -2. 424 1. 00 32.81 C
ATOM 2186 CD1 LEU B 86 -33. 080 -53. 672 - 1. 585 1. 00 33.47 CATOM 2186 CD1 LEU B 86 -33. 080 -53. 672-1. 585 1. 00 33.47 C
ATOM 2187 CD2 LEU B 86 -31. 847 -51. 555 - 2. 105 1. 00 33.99 CATOM 2187 CD2 LEU B 86 -31. 847 -51. 555-2. 105 1. 00 33.99 C
ATOM 2188 C LEU B 86 - 33. 291 -52. 167 - 6. 310 1. 00 32.82 CATOM 2188 C LEU B 86-33. 291 -52. 167-6. 310 1. 00 32.82 C
ATOM 2189 0 LEU B 86 - 34. 334 -52. 598 - 6. 805 1. 00 33.61 0ATOM 2189 0 LEU B 86-34. 334 -52. 598-6. 805 1. 00 33.61 0
ATOM 2190 N AR6 B 87 -32. 138 -52. 147 一 6. 975 1. 00 32.17 NATOM 2190 N AR6 B 87 -32. 138 -52. 147 One 6. 975 1. 00 32.17 N
ATOM 2191 CA ARG B 87 -30. 909 -51. 611 -6. 409 1. ,00 32.94 CATOM 2191 CA ARG B 87 -30. 909 -51. 611 -6. 409 1., 00 32.94 C
ATOM 2192 CB ARG B 87 -29. 693 -52. 310 -7. 013 1. 00 35.84 CATOM 2192 CB ARG B 87 -29. 693 -52. 310 -7. 013 1. 00 35.84 C
ATOM 2193 CG ARG B 87 -29. 576 -53. 779 - 6. 728 1. ,00 37.57 CATOM 2193 CG ARG B 87 -29. 576 -53. 779-6. 728 1., 00 37.57 C
ATOM 2194 CD ARG B 87 -28. 377 - 54. 328 -7. 476 1. .00 38.82 CATOM 2194 CD ARG B 87 -28. 377-54. 328 -7. 476 1. .00 38.82 C
ATOM 2195 NE ARG B 87 -28. 570 -54. 226 - 8. 921 1. ,00 40.11 NATOM 2195 NE ARG B 87 -28. 570 -54. 226-8. 921 1., 00 40.11 N
ATOM 2196 CZ ARG B 87 -27. 584 -54. 223 - 9. 809 1. .00 38.52 CATOM 2196 CZ ARG B 87 -27. 584 -54. 223-9. 809 1. .00 38.52 C
ATOM 2197 NH1 ARG B 87 - 27, 861 -54. 130 - 11. 103 1. .00 38.86 NATOM 2197 NH1 ARG B 87-27, 861 -54. 130-11. 103 1. .00 38.86 N
ATOM 2198 NH2 ARG B 87 - 26. 323 -54. 307 -9. 401 1. .00 35.76 .ATOM 2198 NH2 ARG B 87-26. 323 -54. 307 -9. 401 1. .00 35.76.
ATOM 2199 C ARG B 87 -30. 758 - 50. 120 -6. 677 1. ,00 31.44 CATOM 2199 C ARG B 87 -30. 758-50. 120 -6. 677 1., 00 31.44 C
ATOM 2200 0 ARG B 87 -30. 330 -49. 367 -5. 803 1, .00 27.87 0ATOM 2200 0 ARG B 87 -30. 330 -49. 367 -5. 803 1, .00 27.87 0
ATOM 2201 N ALA B 88 -31. 083 -49. 711 -7. 900 1. .00 32.13 NATOM 2201 N ALA B 88 -31. 083 -49. 711 -7. 900 1. .00 32.13 N
ATOM 2202 CA ALA B 88 -30. 635 -48. 423 - 8. 423 1, .00 34.02 CATOM 2202 CA ALA B 88 -30. 635 -48. 423-8. 423 1, .00 34.02 C
ATOM 2203 CB ALA B 88 -31. 041 -48. 284 - 9. 887 1, .00 32.88 CATOM 2203 CB ALA B 88 -31. 041 -48. 284-9. 887 1, .00 32.88 C
ATOM 2204 C ALA B 88 -31. 185 -47. 256 -7. 608 1, .00 34.92 CATOM 2204 C ALA B 88 -31. 185 -47. 256 -7. 608 1, .00 34.92 C
ATOM 2205 0 ALA B 88 -30. 617 -46. 164 -7. 600 1, ■ 00 36.11 0ATOM 2205 0 ALA B 88 -30. 617 -46. 164 -7. 600 1, ∎ 00 36.11 0
ATOM 2206 N GLY B 89 -32. ,289 - 47. 495 -6. 915 1 • 00 34.86 NATOM 2206 N GLY B 89 -32., 289-47. 495 -6. 915 1 • 00 34.86 N
ATOM 2207 CA GLY B 89 -32. 825 -46. 480 一 6. 036 1, ■ 00 34.20 C ATOM 2208 C GLY B 89 -45.969 -5.051 1.00 34.35 CATOM 2207 CA GLY B 89 -32. 825 -46. 480 One 6. 036 1, ■ 00 34.20 C ATOM 2208 C GLY B 89 -45.969 -5.051 1.00 34.35 C
ATOM 2209 0 GLY B 89 -31.858 -44.817 -4.619 1. 00 34.61 0ATOM 2209 0 GLY B 89 -31.858 -44.817 -4.619 1.00 34.61 0
ATOM 2210 N LEU B 90 -30.836 -46.811 -4.686 1. 00 32.93 NATOM 2210 N LEU B 90 -30.836 -46.811 -4.686 1. 00 32.93 N
ATOM 2211 CA LEU B 90 -29.848 -46.396 -3.700 1. 00 33.98 CATOM 2211 CA LEU B 90 -29.848 -46.396 -3.700 1.00 33.98 C
ATOM 2212 GB LEU B 90 -28.895 -47.543 -3.366 1. 00 33.89 CATOM 2212 GB LEU B 90 -28.895 -47.543 -3.366 1. 00 33.89 C
ATOM 2213 CG LEU B 90 -29.456 -48.676 -2.500 1. 00 38.13 CATOM 2213 CG LEU B 90 -29.456 -48.676 -2.500 1. 00 38.13 C
ATOM 2214 CD1 LEU B 90 - 28.369 -49.713 -2.243 1. 00 35.99 CATOM 2214 CD1 LEU B 90-28.369 -49.713 -2.243 1. 00 35.99 C
ATOM 2215 CD2 LEU B 90 -29.977 -48.107 - 1.182 1. 00 38.22 CATOM 2215 CD2 LEU B 90 -29.977 -48.107-1.182 1.00 38.22 C
ATOM 2216 C LEU B 90 -29.053 -45.215 -4.233 1. 00 33.19 CATOM 2216 C LEU B 90 -29.053 -45.215 -4.233 1.00 33.19 C
ATOM 2217 0 LEU B 90 -28.549 -44.399 -3.468 1. 00 33.78 0ATOM 2217 0 LEU B 90 -28.549 -44.399 -3.468 1. 00 33.78 0
ATOM 2218 N GLY B 91 -28.959 -45.124 -5.554 1. 00 32.70 NATOM 2218 N GLY B 91 -28.959 -45.124 -5.554 1. 00 32.70 N
ATOM 2219 ■CA GLY B 91 -28.052 -44.174 -6.165 1. 00 30.85 CATOM 2219 CA GLY B 91 -28.052 -44.174 -6.165 1. 00 30.85 C
ATOM 2220 C GLY B 91 -28.575 -42.754 -6.214 1. 00 30.06 CATOM 2220 C GLY B 91 -28.575 -42.754 -6.214 1. 00 30.06 C
ATOM 2221 0 GLY B 91 - 27.836 - 41.840 - 6.567 1. 00 28.02 0ATOM 2221 0 GLY B 91-27.836-41.840-6.567 1. 00 28.02 0
ATOM 2222 N MET B 92 -29.847 -42.568 -5.872 1. 00 30.50 NATOM 2222 N MET B 92 -29.847 -42.568 -5.872 1. 00 30.50 N
ATOM 2223 CA MET B 92 -30.443 -41.232 -5.811 1. 00 30.11 CATOM 2223 CA MET B 92 -30.443 -41.232 -5.811 1. 00 30.11 C
ATOM 2224 CB MET B 92 -41.224 -6.522 1. 00 29.68 CATOM 2224 CB MET B 92 -41.224 -6.522 1. 00 29.68 C
ATOM 2225 C6 MET B 92 -31.723 -41 · 283 -8.043 1. 00 30.21 CATOM 2225 C6 MET B 92 -31.723 -41283 -8.043 1.00 30.21 C
ATOM 2226 SD MET B 92 -33.331 -41.671 - 8.786 1. 00 32.25 SATOM 2226 SD MET B 92 -33.331 -41.671-8.786 1. 00 32.25 S
ATOM 2227 CE MET B 92 -34.141 - 40.099 - 8.731 1. 00 27.53 CATOM 2227 CE MET B 92 -34.141-40.099-8.731 1.00 27.53 C
ATOM 2228 C MET B 92 -30.632 -40.787 - 4.362 1. ,00 29.96 CATOM 2228 C MET B 92 -30.632 -40.787-4.362 1., 00 29.96 C
ATOM 2229 0 MET B 92 -30.938 -39.625 -4.085 1. 00 30.83 0ATOM 2229 0 MET B 92 -30.938 -39.625 -4.085 1.00 30.83 0
ATOM 2230 N MET B 93 -30.443 -41.725 -3.444 1. ,00 NATOM 2230 N MET B 93 -30.443 -41.725 -3.444 1., 00 N
ATOM 2231 CA MET B 93 -30.871 -41.566 -2.061 1. ,00 29.53 CATOM 2231 CA MET B 93 -30.871 -41.566 -2.061 1., 00 29.53 C
ATOM 2232 CB MET B 93 - 30.685 -42.898 -1.322 1. ,00 30.89 CATOM 2232 CB MET B 93-30.685 -42.898 -1.322 1., 00 30.89 C
ATOM 2233 CG MET B 93 - 42.897 0.123 1. .00 35.85 CATOM 2233 CG MET B 93-42.897 0.123 1. .00 35.85 C
ATOM 2234 SD MET B 93 - 30.727一 44.440 0.965 1. .00 40.52 SATOM 2234 SD MET B 93-30.727 1 44.440 0.965 1. .00 40.52 S
ATOM 2235 CE MET B 93 -28.992 -44.194 1.329 1. .00 38.21 CATOM 2235 CE MET B 93 -28.992 -44.194 1.329 1. .00 38.21 C
ATOM 2236 C MET B 93 -30.143 -40.438 -1.324 1, .00 27.91 CATOM 2236 C MET B 93 -30.143 -40.438 -1.324 1, .00 27.91 C
ATOM 2237 0 MET B 93 - 30.764 -39.687 -0.566 1, .00 25.95 0ATOM 2237 0 MET B 93-30.764 -39.687 -0.566 1, .00 25.95 0
ATOM 2238 N ASP B 94 - 28.836 -40.313 -1.552 1, .00 26.43 NATOM 2238 N ASP B 94-28.836 -40.313 -1.552 1, .00 26.43 N
ATOM 2239 CA ASP B 94 - 28.031 -39.325 - 0.842 1. .00 26.06 CATOM 2239 CA ASP B 94-28.031 -39.325-0.842 1. .00 26.06 C
ATOM 2240 CB ASP B 94 -26.543 -39.619 - 1.013 1, .00 29.28 CATOM 2240 CB ASP B 94 -26.543 -39.619-1.013 1, .00 29.28 C
ATOM 2241 CG ASP B 94 -26.084 -40.797 -0.181 1, .00 31.80 CATOM 2241 CG ASP B 94 -26.084 -40.797 -0.181 1, .00 31.80 C
ATOM 2242 0D1 ASP B 94 -24.878 -41.097 - 0.208 1 .00 29.44 0ATOM 2242 0D1 ASP B 94 -24.878 -41.097-0.208 1 .00 29.44 0
ATOM 2243 0D2 ASP B 94 一 26.934 -41.422 0.496 1, .00 34.98 0 ATOM 2244 C ASP B 94 -28.308 - 37.907 -1.299 1.00 27.15 CATOM 2243 0D2 ASP B 94 1 26.934 -41.422 0.496 1, .00 34.98 0 ATOM 2244 C ASP B 94 -28.308-37.907 -1.299 1.00 27.15 C
ATOM 2245 0 ASP B 94 -28.143 -36.959 -0.533 1. 00 25.99 0ATOM 2245 0 ASP B 94 -28.143 -36.959 -0.533 1.00 25.99 0
ATOM 2246 N GLY B 95 -28.717 -37.764 -2.554 1. 00 27.15 NATOM 2246 N GLY B 95 -28.717 -37.764 -2.554 1.00 27.15 N
ATOM 2247 CA GLY B 95 -29.149 -36.469 -3.035 1. 00 27.18 CATOM 2247 CA GLY B 95 -29.149 -36.469 -3.035 1. 00 27.18 C
ATOM 2248 C GLY B 95 -30.391 - 35.998 -2.297 1. 00 27.71 CATOM 2248 C GLY B 95 -30.391-35.998 -2.297 1.00 27.71 C
ATOM 2249 0 GLY B 95 -30.505 - 34.819 -1.949 1. 00 28.24 0ATOM 2249 0 GLY B 95 -30.505-34.819 -1.949 1.00 28.24 0
ATOM 2250 N VAL B 96 -31.320 -36.912 - 2.049 1. 00 26.15 NATOM 2250 N VAL B 96 -31.320 -36.912-2.049 1. 00 26.15 N
ATOM 2251 CA VAL B 96 - 32.546 - 36.562 -1.346 1. 00 27.52 CATOM 2251 CA VAL B 96-32.546-36.562 -1.346 1. 00 27.52 C
ATOM 2252 CB VAL B 96 -33.578 -37.723 -1■ 387 1. 00 28.78 CATOM 2252 CB VAL B 96 -33.578 -37.723 -1 ■ 387 1. 00 28.78 C
ATOM 2253 CG1 VAL B 96 -34.818 -37.339 - 0.594 1. 00 28.01 CATOM 2253 CG1 VAL B 96 -34.818 -37.339-0.594 1.00 28.01 C
ATOM 2254 CG2 VAL B 96 -33.955 -38.050 - 2.838 1. 00 26.56 CATOM 2254 CG2 VAL B 96 -33.955 -38.050-2.838 1. 00 26.56 C
ATOM 2255 C VAL B 96 - 32.255 -36.210 0.115 1. 00 28.93 CATOM 2255 C VAL B 96-32.255 -36.210 0.115 1. 00 28.93 C
ATOM 2256 0 VAL B 96 -32.806 -35.243 0.649 1. 00 27.00 0ATOM 2256 0 VAL B 96 -32.806 -35.243 0.649 1. 00 27.00 0
ATOM 2257 N LEU B 97 -31.387 -36.994 0.752 1. 00 28.39 NATOM 2257 N LEU B 97 -31.387 -36.994 0.752 1. 00 28.39 N
ATOM 2258 CA LEU B 97 - 31.044 -36.783 2.157 1. 00 28.92 CATOM 2258 CA LEU B 97-31.044 -36.783 2.157 1. 00 28.92 C
ATOM 2259 CB LEU B 97 - 30.214 -37.956 2.672 1. 00 28.16 CATOM 2259 CB LEU B 97-30.214 -37.956 2.672 1. 00 28.16 C
ATOM 2260 CG LEU B 97 -30.946 -39.301 2.756 1. 00 26.58 CATOM 2260 CG LEU B 97 -30.946 -39.301 2.756 1. 00 26.58 C
ATOM 2261 CD1 LEU B 97 - 29.966 -40.400 3.092 1. ,00 27.22 CATOM 2261 CD1 LEU B 97-29.966 -40.400 3.092 1., 00 27.22 C
ATOM 2262 CD2 LEU B 97 - 32.037 - 39.213 3.805 1. 00 24.03 CATOM 2262 CD2 LEU B 97-32.037-39.213 3.805 1.00 24.03 C
ATOM 2263 C LEU B 97 -30.269 -35.486 2.345 1. .00 30.57 CATOM 2263 C LEU B 97 -30.269 -35.486 2.345 1. .00 30.57 C
ATOM 2264 0 LEU B 97 -30.215 -34.926 3.438 1. ,00 31.81 0ATOM 2264 0 LEU B 97 -30.215 -34.926 3.438 1., 00 31.81 0
ATOM 2265 N GLU B 98 -29.661 -35.016 1.266 1. ,00 32.20 NATOM 2265 N GLU B 98 -29.661 -35.016 1.266 1., 00 32.20 N
ATOM 2266 CA GLU B 98 - 28.976 - 33.729 ΐ.262 1. ,00 33.72 CATOM 2266 CA GLU B 98-28.976-33.729 ΐ.262 1., 00 33.72 C
ATOM 2267 CB GLU B 98 - 28.423 -33.467 -0.143 1. .00 35.29 CATOM 2267 CB GLU B 98-28.423 -33.467 -0.143 1. .00 35.29 C
ATOM 2268 CG GLU B 98 -27.842 -32.084 -0.382 1. ,00 42.20 CATOM 2268 CG GLU B 98 -27.842 -32.084 -0.382 1., 00 42.20 C
ATOM 2269 CD GLU B 98 -27.486 -31.853 - 1.853 1. ,00 45.23 CATOM 2269 CD GLU B 98 -27.486 -31.853-1.853 1., 00 45.23 C
ATOM 2270 0E1 GLU B 98 -27.034 - 32.813 -2.522 1. .00 44.95 0ATOM 2270 0E1 GLU B 98 -27.034-32.813 -2.522 1. .00 44.95 0
ATOM 2271 0E2 GLU B 98 -27.662 -30.714 -2.341 1. .00 46.80 0ATOM 2271 0E2 GLU B 98 -27.662 -30.714 -2.341 1. .00 46.80 0
ATOM 2272 C GLU B 98 -29.979 -32.646 1.658 1. .00 32.90 CATOM 2272 C GLU B 98 -29.979 -32.646 1.658 1. .00 32.90 C
ATOM 2273 0 GLU B 98 -29.660 -31.713 2.396 1, .00 34.75 0ATOM 2273 0 GLU B 98 -29.660 -31.713 2.396 1, .00 34.75 0
ATOM 2274 N ASN B 99 - 31.205 -32.795 1, .00 30.76 NATOM 2274 N ASN B 99-31.205 -32.795 1, .00 30.76 N
ATOM 2275 CA ASN B 99 -32.238 -31.799 1.380 1, .00 30.45 CATOM 2275 CA ASN B 99 -32.238 -31.799 1.380 1, .00 30.45 C
ATOM 2276 CB ASN B 99 - 33.178 -31.796 0.178 1, .00 31.49 CATOM 2276 CB ASN B 99-33.178 -31.796 0.178 1, .00 31.49 C
ATOM 2277 CG ASN B 99 -32.521 -31.239 -1.065 1 • 00 30.01 CATOM 2277 CG ASN B 99 -32.521 -31.239 -1.065 1 • 00 30.01 C
ATOM 2278 0D1 ASN B 99 - 32.619 - 30.048 -1.343 1, .00 29.77 0ATOM 2278 0D1 ASN B 99-32.619-30.048 -1.343 1, .00 29.77 0
ATOM 2279 ND2 ASN B 99 - 32.099 一 1.816 1 .00 27.97 N
Figure imgf000093_0001
ATOM 2279 ND2 ASN B 99-32.099 One 1.816 1 .00 27.97 N
Figure imgf000093_0001
Z Z Z Z O O O O Z O O O Z O O O O Z O i O O Z O O ZZZZOOOOZOOOZOOOOZO i OOZOO
ATOM 2316 C ARG B 104 -36.223 -42.445 6.379 1.00 36.20 CATOM 2316 C ARG B 104 -36.223 -42.445 6.379 1.00 36.20 C
ATOM 2317 0 ARG B 104 -36.734 - 42.021 5.345 1. 00 38.07 0ATOM 2317 0 ARG B 104 -36.734-42.021 5.345 1. 00 38.07 0
ATOM 2318 N ILE B 105 -35.422 -43.503 6.410 1. 00 34.19 NATOM 2318 N ILE B 105 -35.422 -43.503 6.410 1. 00 34.19 N
ATOM 2319 CA ILE B 105 -35.128 -44.279 5.213 1. 00 33.32 CATOM 2319 CA ILE B 105 -35.128 -44.279 5.213 1. 00 33.32 C
ATOM 2320 CB ILE B 105 - 33.610 —44.448 5.019 1. 00 32.38 CATOM 2320 CB ILE B 105-33.610 --44.448 5.019 1. 00 32.38 C
ATOM 2321 C62 ILE B 105 -33.333 -45.220 3.741 1. 00 29.30 CATOM 2321 C62 ILE B 105 -33.333 -45.220 3.741 1. 00 29.30 C
ATOM 2322 C61 ILE B 105 -32.937 -43.071 4.996 1. 00 34.36 CATOM 2322 C61 ILE B 105 -32.937 -43.071 4.996 1.00 34.36 C
ATOM 2323 CD1 ILE B 105 -31. 430 -43.111 4.798 1. 00 37.28 CATOM 2323 CD1 ILE B 105 -31. 430 -43.111 4.798 1. 00 37.28 C
ATOM 2324 C ILE B 105 -35.765 -45.668 5.291 1. 00 33.87 CATOM 2324 C ILE B 105 -35.765 -45.668 5.291 1. 00 33.87 C
ATOM 2325 0 ILE B 105 -35.480 -46.447 6.202 1. 00 33.23 0ATOM 2325 0 ILE B 105 -35.480 -46.447 6.202 1. 00 33.23 0
ATOM 2326 N SER B 106 -36. 628 -45.977 4.334 1. 00 33. 88 NATOM 2326 N SER B 106 -36. 628 -45.977 4.334 1. 00 33. 88 N
ATOM 2327 CA SER B 106 -37. 229 -47.299 4.288 1. 00 34. 37 CATOM 2327 CA SER B 106 -37. 229 -47.299 4.288 1. 00 34. 37 C
ATOM 2328 CB SER B 106 -38. 727 -47.217 4.549 1. 00 33. 19 . CATOM 2328 CB SER B 106 -38. 727 -47.217 4.549 1. 00 33. 19. C
ATOM 2329 06 SER B 106 -39. 107 -48.227 5.464 1. 00 36. 35 0ATOM 2329 06 SER B 106 -39. 107 -48.227 5.464 1. 00 36. 35 0
ATOM 2330 C SER B 106 一 36. 975 - 47.957 2.947 1. 00 34. 37 CATOM 2330 C SER B 106 1 36. 975-47.957 2.947 1. 00 34. 37 C
ATOM 2331 0 SER B 106 -37. 658 - 47.671 1.965 1. 00 34. 89 0ATOM 2331 0 SER B 106 -37. 658-47.671 1.965 1. 00 34. 89 0
ATOM 2332 N VAL B 107 -35. 985 -48.841 2.924 1. 00 34. 08 NATOM 2332 N VAL B 107 -35. 985 -48.841 2.924 1. 00 34. 08 N
ATOM 2333 CA VAL B 107 -35. 570 -49.515 1.709 1. 00 34. 16 CATOM 2333 CA VAL B 107 -35. 570 -49.515 1.709 1. 00 34. 16 C
ATOM 2334 CB VAL B 107 -34. 228 - 50.251 1.914 1. 00 34. 63 CATOM 2334 CB VAL B 107 -34. 228-50.251 1.914 1. 00 34. 63 C
ATOM 2335 CG1 VAL B 107 - 33. 938 - 51.132 0.715 1. .00 36. 39 CATOM 2335 CG1 VAL B 107-33. 938-51.132 0.715 1. .00 36. 39 C
ATOM 2336 CG2 VAL B 107 - 33. 099 -49.244 2.105 1. 00 33. 41 CATOM 2336 CG2 VAL B 107-33. 099 -49.244 2.105 1. 00 33. 41 C
ATOM 2337 C VAL B 107 -36. 618 -50.530 1. ,00 35. 35 CATOM 2337 C VAL B 107 -36. 618 -50.530 1., 00 35. 35 C
ATOM 2338 0 VAL B 107 -37. 096 -51.314 2.114 1. ,00 37. 06 0ATOM 2338 0 VAL B 107 -37. 096 -51.314 2.114 1., 00 37. 06 0
ATOM 2339 N VAL B 108 -36. 975 -50.512 0.019 1, .00 34. 80 NATOM 2339 N VAL B 108 -36. 975 -50.512 0.019 1, .00 34. 80 N
ATOM 2340 CA VAL B 108 -37. 898 -51.496 -0.523 1. .00 35. 74 CATOM 2340 CA VAL B 108 -37. 898 -51.496 -0.523 1. .00 35. 74 C
ATOM 2341 CB VAL B 108 -39. 151 -50.819 - 1.110 1. ,00 35. 71 CATOM 2341 CB VAL B 108 -39. 151 -50.819-1.110 1., 00 35. 71 C
ATOM 2342 CG1 VAL B 108 -40. 016 -51.853 - 1.830 1. .00 34. 36 CATOM 2342 CG1 VAL B 108 -40. 016 -51.853-1.830 1. .00 34. 36 C
ATOM 2343 C62 VAL B 108 -39. 930 -50.132 - 0.001 1. .00 32. 50 CATOM 2343 C62 VAL B 108 -39. 930 -50.132-0.001 1. .00 32. 50 C
ATOM 2344 C VAL B 108 - 37. 210 -52.288 -1.623 1. .00 35. 80 CATOM 2344 C VAL B 108-37. 210 -52.288 -1.623 1. .00 35. 80 C
ATOM 2345 0 VAL B 108 - 36. 588 -51.704 -2.507 1, .00 33. 54 0ATOM 2345 0 VAL B 108-36. 588 -51.704 -2.507 1, .00 33. 54 0
ATOM 2346 N GLY B 109 -37. 317 -53.615 -1.548 1. .00 37. 20 NATOM 2346 N GLY B 109 -37. 317 -53.615 -1.548 1. .00 37. 20 N
ATOM 2347 CA GLY B 109 -36. 848 -54.472 -2.622 1, .00 39. 68 CATOM 2347 CA GLY B 109 -36. 848 -54.472 -2.622 1, .00 39. 68 C
ATOM 2348 C GLY B 109 -37. 991一 55.075 - 3, 426 1, .00 42. 77 CATOM 2348 C GLY B 109 -37. 991 1 55.075-3, 426 1, .00 42. 77 C
ATOM 2349 0 GLY B 109 - 39. 163 -54.899 -3.092 1, .00 43. 50 0ATOM 2349 0 GLY B 109-39. 163 -54.899 -3.092 1, .00 43. 50 0
ATOM 2350 N MET B 110 -37. 656 -55.787 -4.496 1 .00 46. 26 NATOM 2350 N MET B 110 -37. 656 -55.787 -4.496 1 .00 46. 26 N
ATOM 2351 CA MET B 110 一 38. 663一 56.458 -5.319 1, .00 48. 53 C ATOM 2352 CB MET B 110 -38.717 -55.830 - 6.718 1.00 47.52 CATOM 2351 CA MET B 110 1 38. 663 1 56.458 -5.319 1, .00 48. 53 C ATOM 2352 CB MET B 110 -38.717 -55.830-6.718 1.00 47.52 C
ATOM 2353 CG MET B 110 -39.297 -54.417 -6.754 1. 00 49.74 CATOM 2353 CG MET B 110 -39.297 -54.417 -6.754 1. 00 49.74 C
ATOM 2354 SD MET B 110 - 41.111 -54.367 -6. 694 1. 00 52.87 SATOM 2354 SD MET B 110-41.111 -54.367 -6. 694 1. 00 52.87 S
ATOM 2355 CE MET B 110 - 41.393 - 53.046 -5. 538 1. 00 52.13 CATOM 2355 CE MET B 110-41.393-53.046 -5. 538 1. 00 52.13 C
ATOM 2356 C MET B 110 -38.333 - 57.941 - 5. 435 1. 00 50.21 CATOM 2356 C MET B 110 -38.333-57.941-5. 435 1. 00 50.21 C
ATOM 2357 0 MET B 110 -37.182 - 58.308 -5. 660 1. 00 49.82 0ATOM 2357 0 MET B 110 -37.182-58.308 -5. 660 1. 00 49.82 0
ATOM 2358 N TYR B 111 - 39.345 - 58.788 - 5. 277 1. 00 53.84 NATOM 2358 N TYR B 111-39.345-58.788-5. 277 1. 00 53.84 N
ATOM 2359 CA TYR B 111 -39.160 -60.237 - 5. 373 1. 00 57.42 CATOM 2359 CA TYR B 111 -39.160 -60.237-5. 373 1. 00 57.42 C
ATOM 2360 CB TYR B 111 -40.242 -60.967 -4. 581 1. 00 59.24 CATOM 2360 CB TYR B 111 -40.242 -60.967 -4. 581 1. 00 59.24 C
ATOM 2361 CG TYR B 111 -39.787 -61.431 - 3. 225 1 00 62.82 CATOM 2361 CG TYR B 111 -39.787 -61.431-3. 225 1 00 62.82 C
ATOM 2362 CD1 TYR B 111 -40.429 -61.001 -2. 070 1 00 65.47 CATOM 2362 CD1 TYR B 111 -40.429 -61.001 -2. 070 1 00 65.47 C
ATOM 2363 'CE1 TYR B 111 -40.011 -61.426 -0. 818 1. 00 66.49 CATOM 2363 'CE1 TYR B 111 -40.011 -61.426 -0. 818 1. 00 66.49 C
ATOM 2364 CD2 TYR B 111 -38.712 -62.300 - 3. 095 1. 00 64.04 . CATOM 2364 CD2 TYR B 111 -38.712 -62.300-3.095 1.00 64.04 .C
ATOM 2365 CE2 TYR B 111 -38.287 -62.729 - 1. 852 1 00 66.35 CATOM 2365 CE2 TYR B 111 -38.287 -62.729-1. 852 1 00 66.35 C
ATOM 2366 CZ TYR B 111 - 38.940 -62.288 -0. 717 1 00 67.16 CATOM 2366 CZ TYR B 111-38.940 -62.288 -0. 717 1 00 67.16 C
ATOM 2367 OH TYR B 111 -38.519 - 62.709 0. 523 1 00 69.48 0ATOM 2367 OH TYR B 111 -38.519-62.709 0. 523 1 00 69.48 0
ATOM 2368 C TYR B 111 -39.204 - 60.714 - 6. 815 1 00 58.67 CATOM 2368 C TYR B 111 -39.204-60.714-6. 815 1 00 58.67 C
ATOM 2369 0 TYR B 111 -40.273 -60.774 -7. 421 1 00 59.16 0ATOM 2369 0 TYR B 111 -40.273 -60.774 -7. 421 1 00 59.16 0
ATOM 2370 N ARG B 112 -38.042 -61.063 -7. 356 1 00 60.09 NATOM 2370 N ARG B 112 -38.042 -61.063 -7. 356 1 00 60.09 N
ATOM 2371 CA ARG B 112 -37.946 -61.468 - 8. 752 1 00 61.44 CATOM 2371 CA ARG B 112 -37.946 -61.468-8. 752 1 00 61.44 C
ATOM 2372 CB ARG B 112 -37.462 -60.297 - 9. 607 1 00 63.06 CATOM 2372 CB ARG B 112 -37.462 -60.297-9. 607 1 00 63.06 C
ATOM 2373 CG ARG B 112 -38.154 - 58.978 -9. 307 1 00 63.86 CATOM 2373 CG ARG B 112 -38.154-58.978 -9. 307 1 00 63.86 C
ATOM 2374 CD ARG B 112 -38.093 -58.047 -10.502 1 00 66.23 CATOM 2374 CD ARG B 112 -38.093 -58.047 -10.502 1 00 66.23 C
ATOM 2375 NE ARG B 112 -39.145 -58.350 -11. 467 1 00 68.13 NATOM 2375 NE ARG B 112 -39.145 -58.350 -11. 467 1 00 68.13 N
ATOM 2376 CZ ARG B 112 -40.125 -57.513 -11. 792 1 00 69.74 CATOM 2376 CZ ARG B 112 -40.125 -57.513 -11. 792 1 00 69.74 C
ATOM 2377 NH1 ARG B 112 -40.191 -56.311 -11. 232 1 00 69.24 NATOM 2377 NH1 ARG B 112 -40.191 -56.311 -11. 232 1 00 69.24 N
ATOM 2378 NH2 ARG B 112 -41.048 -57.881 -12. 672 1 00 71.84 NATOM 2378 NH2 ARG B 112 -41.048 -57.881 -12. 672 1 00 71.84 N
ATOM 2379 C ARG B 112 -36.989 -62.644 -8. 912 1 00 61.92 CATOM 2379 C ARG B 112 -36.989 -62.644 -8. 912 1 00 61.92 C
ATOM 2380 0 ARG B 112 -37.417 -63.787 -9 062 1 00 61.80 0ATOM 2380 0 ARG B 112 -37.417 -63.787 -9 062 1 00 61.80 0
ATOM 2381 N LEU B 117 -42.813 -64.168 -12 549 1 00 73.06 NATOM 2381 N LEU B 117 -42.813 -64.168 -12 549 1 00 73.06 N
ATOM 2382 CA LEU B 117 -44.112 -63.534 -12 744 1 00 73.39 CATOM 2382 CA LEU B 117 -44.112 -63.534 -12 744 1 00 73.39 C
ATOM 2383 CB LEU B 117 -45.136 - 64.091 -11 746 1 00 73.45 CATOM 2383 CB LEU B 117 -45.136-64.091 -11 746 1 00 73.45 C
ATOM 2384 CG LEU B 117 -45.454 - 65.586 - 11 793 1 00 73.49 GATOM 2384 CG LEU B 117 -45.454-65.586-11 793 1 00 73.49 G
ATOM 2385 CD1 LEU B 117 -45.712 - 65.997 -13 233 1 00 73.49 CATOM 2385 CD1 LEU B 117 -45.712-65.997 -13 233 1 00 73.49 C
ATOM 2386 CD2 LEU B 117 -44.303 - 66.386 - 11 204 1 00 73.35 CATOM 2386 CD2 LEU B 117 -44.303-66.386-11 204 1 00 73.35 C
ATOM 2387 C LEU B 117 -44.014一 62.020 -12 566 1 • 00 73.85 C ATOM 2388 0 LEU B 117 -43.195 -61.356 - 13.207 1.00 73.31 0ATOM 2387 C LEU B 117 -44.014 1 62.020 -12 566 1 • 00 73.85 C ATOM 2388 0 LEU B 117 -43.195 -61.356-13.207 1.00 73.31 0
ATOM 2389 N GLU B 118 -44.865 -61. 489 - 11.689 1. 00 73.88 ΝATOM 2389 N GLU B 118 -44.865 -61. 489-11.689 1. 00 73.88 Ν
ATOM 2390 CA GLU B 118 -44.852 -60.073 1. 00 73.26 CATOM 2390 CA GLU B 118 -44.852 -60.073 1. 00 73.26 C
ATOM 2391 CB GLU B 118 -46.285 -59.546 - 11.224 1. 00 74.47 CATOM 2391 CB GLU B 118 -46.285 -59.546-11.224 1. 00 74.47 C
ATOM 2392 CG GLU B 118 -47.110 -60.230 -10.143 1. 00 76.52 CATOM 2392 CG GLU B 118 -47.110 -60.230 -10.143 1. 00 76.52 C
ATOM 2393 CD GLU B 118 - 48.513 -59.661 -10.028 1. 00 78.16 CATOM 2393 CD GLU B 118-48.513 -59.661 -10.028 1. 00 78.16 C
ATOM 2394 0E1 GLU B 118 -49.137 -59.822 -8.955 1. 00 78.21 0ATOM 2394 0E1 GLU B 118 -49.137 -59.822 -8.955 1. 00 78.21 0
ATOM 2395 0E2 GLU B 118 -48.991 一 59.053 -11.012 1. 00 78.44 0ATOM 2395 0E2 GLU B 118 -48.991 One 59.053 -11.012 1.00 78.44 0
ATOM 2396 C GLU B 118 -44.133 -59.885 -10.003 1. 00 72.25 CATOM 2396 C GLU B 118 -44.133 -59.885 -10.003 1. 00 72.25 C
ATOM 2397 0 GLU B 118 -44.065 -60.808 -9.186 1. 00 71.89 0ATOM 2397 0 GLU B 118 -44.065 -60.808 -9.186 1.00 71.89 0
ATOM 2398 N PRO B 119 -43.591 - 58. 679 -9.766 1. 00 70.74 ΝATOM 2398 N PRO B 119 -43.591-58. 679 -9.766 1. 00 70.74 Ν
ATOM 2399 CD PRO B 119 - 43.741 -57. 501 -10.641 1. 00 70.53 CATOM 2399 CD PRO B 119-43.741 -57. 501 -10.641 1. 00 70.53 C
ATOM 2400 CA PRO B 119 -42. 788 - 58. 379 -8.573 1. 00 68.35 CATOM 2400 CA PRO B 119 -42. 788-58. 379 -8.573 1. 00 68.35 C
ATOM 2401 CB PRO B 119 -42. 219 -56. 993 -8.863 1. 00 69.21 CATOM 2401 CB PRO B 119 -42. 219 -56. 993 -8.863 1. 00 69.21 C
ATOM 2402 CG PRO B 119 - 43. 216 -56. 370 -9.796 1. 00 70.61 CATOM 2402 CG PRO B 119-43. 216 -56. 370 -9.796 1. 00 70.61 C
ATOM 2403 C PRO B 119 -43. 596 -58. 397 -7.280 1. 00 66.24 CATOM 2403 C PRO B 119 -43. 596 -58. 397 -7.280 1. 00 66.24 C
ATOM 2404 0 PRO B 119 - 44. 761 -58. 006 -7.260 1. ,00 66.27 0ATOM 2404 0 PRO B 119-44. 761 -58. 006 -7.260 1., 00 66.27 0
ATOM 2405 N VAL B 120 - 42. 971 -58. 856 -6.203 1. .00 63.75 ΝATOM 2405 N VAL B 120-42. 971 -58. 856 -6.203 1. .00 63.75 Ν
ATOM 2406 CA VAL B 120 - 43. 549 -58. 715 -4.873 1. 00. 61.73 CATOM 2406 CA VAL B 120-43. 549 -58. 715 -4.873 1. 00. 61.73 C
ATOM 2407 CB VAL B 120 -43. 581 -60. 064 -4.125 1. ,00 62.54 CATOM 2407 CB VAL B 120 -43. 581 -60. 064 -4.125 1., 00 62.54 C
ATOM 2408 CG1 VAL B 120 -44. 231 -59. 885 - 2.764 1. ,00 62.94 CATOM 2408 CG1 VAL B 120 -44. 231 -59. 885-2.764 1., 00 62.94 C
ATOM 2409 CG2 VAL B 120 - 44. 337 -61. 095 -4.941 1. ,00 63.22 CATOM 2409 CG2 VAL B 120-44. 337 -61. 095 -4.941 1., 00 63.22 C
ATOM 2410 C VAL B 120 -42. 715 -57. 732 -4.059 1. ,00 59.75 CATOM 2410 C VAL B 120 -42. 715 -57.732 -4.059 1., 00 59.75 C
ATOM 2411 0 VAL B 120 - 41. 577 -58. 026 -3.694 1. .00 60.05 0ATOM 2411 0 VAL B 120-41. 577 -58. 026 -3.694 1. .00 60.05 0
ATOM 2412 N PRO B 121 -43. 272 -56. 546 -3.769 1. .00 58.03 ΝATOM 2412 N PRO B 121 -43. 272 -56. 546 -3.769 1. .00 58.03 Ν
ATOM 2413 CD PRO B 121 -44. 600 -56. 083 -4.212 1. .00 57.46 CATOM 2413 CD PRO B 121 -44. 600 -56. 083 -4.212 1. .00 57.46 C
ATOM 2414 CA PRO B 121 -42. 572 -55. 522 - 2.983 1. .00 55.18 CATOM 2414 CA PRO B 121 -42. 572 -55. 522-2.983 1. .00 55.18 C
ATOM 2415 CB PRO B 121 -43. 412 -54. 267 -3.208 1, .00 55.73 CATOM 2415 CB PRO B 121 -43. 412 -54. 267 -3.208 1, .00 55.73 C
ATOM 2416 CG PRO B 121 -44. 784 -54. 786 -3.465 1, .00 56.34 CATOM 2416 CG PRO B 121 -44. 784 -54. 786 -3.465 1, .00 56.34 C
ATOM 2417 C PRO B 121 - 42. 477 -55. 892 -1.502 1, .00 52.30 CATOM 2417 C PRO B 121-42. 477 -55. 892 -1.502 1, .00 52.30 C
ATOM 2418 0 PRO B 121 -43. 478 - 56. 235 - 0.878 1, .00 52.05 0ATOM 2418 0 PRO B 121 -43. 478-56. 235-0.878 1, .00 52.05 0
ATOM 2419 N TYR B 122 -41. 272 -55. 817 -0.947 1, .00 49.60 ΝATOM 2419 N TYR B 122 -41. 272 -55. 817 -0.947 1, .00 49.60 Ν
ATOM 2420 CA TYR B 122 -41. 060 -56. 107 0.467 1, .00 46.75 CATOM 2420 CA TYR B 122 -41. 060 -56. 107 0.467 1, .00 46.75 C
ATOM 2421 CB TYR B 122 -40. 376 -57. 467 0.626 1 .00 45.14 CATOM 2421 CB TYR B 122 -40. 376 -57. 467 0.626 1 .00 45.14 C
ATOM 2422 CG TYR B 122 - 39. 012 -57. 561 - 0.030 1 .00 45.87 CATOM 2422 CG TYR B 122-39. 012 -57. 561-0.030 1 .00 45.87 C
ATOM 2423 CD1 TYR B 122 -38. 880一 57. 952 -1.358 1, ■ 00 44.82 C ATOM 2424 CE1 TYR B 122 -37.636 -58.050 -1.956 1.00 43.77 CATOM 2423 CD1 TYR B 122 -38. 880 1 57. 952 -1.358 1, ■ 00 44.82 C ATOM 2424 CE1 TYR B 122 -37.636 -58.050 -1.956 1.00 43.77 C
ATOM 2425 CD2 TYR B 122 - 37.855 -57.268 0.682 1. 00 44.75 GATOM 2425 CD2 TYR B 122-37.855 -57.268 0.682 1. 00 44.75 G
ATOM 2426 CE2 TYR B 122 - 36.608 -57.362 0.093 1. 00 44.58 CATOM 2426 CE2 TYR B 122-36.608 -57.362 0.093 1. 00 44.58 C
ATOM 2427 CZ TYR B 122 -36.503 -57.754 -1 · 227 1. 00 44.76 CATOM 2427 CZ TYR B 122 -36.503 -57.754 -1 227 1. 00 44.76 C
ATOM 2428 OH TYR B 122 - 35.256 -57.855 -1.815 1. 00 43.18 0ATOM 2428 OH TYR B 122-35.256 -57.855 -1.815 1.00 43.18 0
ATOM 2429 C TYR B 122 -40.217 -55.032 1.150 1. 00 45.89 CATOM 2429 C TYR B 122 -40.217 -55.032 1.150 1. 00 45.89 C
ATOM 2430 0 TYR B 122 - 39.174 -54.624 0.631 1. 00 45.04 0ATOM 2430 0 TYR B 122-39.174 -54.624 0.631 1. 00 45.04 0
ATOM 2431 N PHE B 123 -40.672 -54.577 2.314 1. 00 44.81 NATOM 2431 N PHE B 123 -40.672 -54.577 2.314 1. 00 44.81 N
ATOM 2432 CA PHE B 123 -39.859 -53.714 3.165 1. 00 44.33 CATOM 2432 CA PHE B 123 -39.859 -53.714 3.165 1. 00 44.33 C
ATOM 2433 CB PHE B 123 -40.638 -53.269 4.401 1. 00 43.77 CATOM 2433 CB PHE B 123 -40.638 -53.269 4.401 1.00 43.77 C
ATOM 2434 CG PHE B 123 -41.698 -52.247 4.125 1. 00 42.55 CATOM 2434 CG PHE B 123 -41.698 -52.247 4.125 1. 00 42.55 C
ATOM 2435 'CD1 PHE B 123 - 43.041 -52.563 4.282 1. 00 41.59 CATOM 2435 'CD1 PHE B 123-43.041 -52.563 4.282 1. 00 41.59 C
ATOM 2436 CD2 PHE B 123 -41.356 -50.962 3.740 1. 00 40.87 CATOM 2436 CD2 PHE B 123 -41.356 -50.962 3.740 1.00 40.87 C
ATOM 2437 CE1 PHE B 123 -44.019 - 51.611 4.062 1. 00 41.02 CATOM 2437 CE1 PHE B 123 -44.019-51.611 4.062 1.00 41.02 C
ATOM 2438 CE2 PHE B 123 -42.331 -50.007 3.518 1. 00 39.38 GATOM 2438 CE2 PHE B 123 -42.331 -50.007 3.518 1. 00 39.38 G
ATOM 2439 CZ PHE B 123 -43.660 - 50.329 3.678 1. 00 39.68 CATOM 2439 CZ PHE B 123 -43.660-50.329 3.678 1. 00 39.68 C
ATOM 2440 C PHE B 123 - 38.656 -54.504 3.633 1. 00 45.26 CATOM 2440 C PHE B 123-38.656 -54.504 3.633 1. 00 45.26 C
ATOM 2441 0 PHE B 123 - 38.807 -55.617 4.123 1. 00 47.52 0ATOM 2441 0 PHE B 123-38.807 -55.617 4.123 1.00 47.52 0
ATOM 2442 N GLN B 124 -37.466 -53.932 3.501 1. 00 46.37 NATOM 2442 N GLN B 124 -37.466 -53.932 3.501 1. 00 46.37 N
ATOM 2443 CA GLN B 124 -36.272 -54.575 4.033 1. 00 47.75 CATOM 2443 CA GLN B 124 -36.272 -54.575 4.033 1. 00 47.75 C
ATOM 2444 CB GLN B 124 -35.033 -53.718 3.760 1. ,00 48.66 CATOM 2444 CB GLN B 124 -35.033 -53.718 3.760 1., 00 48.66 C
ATOM 2445 CG GLN B 124 - 33.724 -54.395 4.127 1. 00 48.19 CATOM 2445 CG GLN B 124-33.724 -54.395 4.127 1. 00 48.19 C
ATOM 2446 CD GLN B 124 -33.421 - 55.570 3.224 1. ,00 48.64 CATOM 2446 CD GLN B 124 -33.421-55.570 3.224 1., 00 48.64 C
ATOM 2447 0E1 GLN B 124 -32.723 -56.504 3.610 1. ,00 48.96 0ATOM 2447 0E1 GLN B 124 -32.723 -56.504 3.610 1., 00 48.96 0
ATOM 2448 NE2 GLN B 124 -33.947 -55.527 2.008 1. ,00 50.02 NATOM 2448 NE2 GLN B 124 -33.947 -55.527 2.008 1., 00 50.02 N
ATOM 2449 C GLN B 124 -36.448 -54.764 5.535 1. .00 48.81 CATOM 2449 C GLN B 124 -36.448 -54.764 5.535 1. .00 48.81 C
ATOM 2450 0 GLN B 124 -36.041 -55.777 6.096 1. ,00 49.55 0ATOM 2450 0 GLN B 124 -36.041 -55.777 6.096 1., 00 49.55 0
ATOM 2451 N LYS B 125 - 37, 058 -53.775 6.178 1. .00 50.41 NATOM 2451 N LYS B 125-37, 058 -53.775 6.178 1. .00 50.41 N
ATOM 2452 CA LYS B 125 -37.452 - 53.893 7.575 1. .00 53.10 CATOM 2452 CA LYS B 125 -37.452-53.893 7.575 1. .00 53.10 C
ATOM 2453 CB LYS B 125 -36.347 -53.344 8.484 1, .00 54.08 CATOM 2453 CB LYS B 125 -36.347 -53.344 8.484 1, .00 54.08 C
ATOM 2454 CG LYS B 125 -36.600 -51.941 9.005 1, .00 57.49 CATOM 2454 CG LYS B 125 -36.600 -51.941 9.005 1, .00 57.49 C
ATOM 2455 CD LYS B 125 - 37.147 -51.977 10.423 1, .00 59.28 CATOM 2455 CD LYS B 125-37.147 -51.977 10.423 1, .00 59.28 C
ATOM 2456 CE LYS B 125 -36.212 -52.742 11.351 1 .00 61.26 CATOM 2456 CE LYS B 125 -36.212 -52.742 11.351 1 .00 61.26 C
ATOM 2457 NZ LYS B 125 - 36.651 - 52.674 12.774 1, .00 62.80 NATOM 2457 NZ LYS B 125-36.651-52.674 12.774 1, .00 62.80 N
ATOM 2458 C LYS B 125 -38.758 -53.127 7.792 1 .00 53.75 CATOM 2458 C LYS B 125 -38.758 -53.127 7.792 1 .00 53.75 C
ATOM 2459 0 LYS B 125 -39.133 -52.292 6.975 1 .00 52.91 0 ATOM 2460 N LEU B 126 -39.442 -53.419 8.894 1.00 57.04 NATOM 2459 0 LYS B 125 -39.133 -52.292 6.975 1 .00 52.91 0 ATOM 2460 N LEU B 126 -39.442 -53.419 8.894 1.00 57.04 N
ATOM 2461 CA LEU B 126 - 40.819 - 52, 973 9.109 1. 00 59. 07 CATOM 2461 CA LEU B 126-40.819-52, 973 9.109 1. 00 59. 07 C
ATOM 2462 CB LEU B 126 —41. 375 -53. 586 10.405 1. 00 59. 89 CATOM 2462 CB LEU B 126 —41. 375 -53. 586 10.405 1. 00 59. 89 C
ATOM 2463 CG LEU B 126 -40.708 -53. 414 11. 782 1. 00 59. 44 CATOM 2463 CG LEU B 126 -40.708 -53. 414 11. 782 1. 00 59. 44 C
ATOM 2464 CD1 LEU B 126 -39.367 - 54. 129 11. 805 1. 00 57. 68 CATOM 2464 CD1 LEU B 126 -39.367-54. 129 11. 805 1. 00 57. 68 C
ATOM 2465 CD2 LEU B 126 -40.556 -51. 939 12.122 1. 00 59. 22 CATOM 2465 CD2 LEU B 126 -40.556 -51. 939 12.122 1. 00 59. 22 C
ATOM 2466 C LEU B 126 -41. 025 - 51. 458 9.129 1. 00 60. 76 CATOM 2466 C LEU B 126 -41. 025-51. 458 9.129 1. 00 60. 76 C
ATOM 2467 0 LEU B 126 - 40.109 - 50. 686 9.424 1. 00 64.06 0ATOM 2467 0 LEU B 126-40.109-50. 686 9.424 1. 00 64.06 0
ATOM 2468 N ILE B 130 -47. 401 -44. 200 9. 112 1. 00 70. 87 NATOM 2468 N ILE B 130 -47. 401 -44. 200 9. 112 1. 00 70. 87 N
ATOM 2469 CA ILE B 130 -48. 728 - 43. 662 9. 399 1. 00 72. 57 CATOM 2469 CA ILE B 130 -48. 728-43. 662 9. 399 1. 00 72. 57 C
ATOM 2470 CB ILE B 130 -49. 502一 44. 568 10. 399 1. 00 72. 88 CATOM 2470 CB ILE B 130 -49. 502 1 44. 568 10. 399 1. 00 72. 88 C
ATOM 2471 CG2 ILE B 130 -48. 696一 44. 764 11. 672 1. 00 73. 46 CATOM 2471 CG2 ILE B 130 -48. 696 1 44. 764 11. 672 1. 00 73. 46 C
ATOM 2472 CG1 ILE B 130 -50. 861 -43. 948 10. 724 1. 00 73. 13 ― CATOM 2472 CG1 ILE B 130 -50. 861 -43. 948 10. 724 1. 00 73. 13 ― C
ATOM 2473 CD1 ILE B 130 - 51. 685 -44. 770 11. 696 1. 00 73. 08 CATOM 2473 CD1 ILE B 130-51. 685 -44. 770 11. 696 1. 00 73. 08 C
ATOM 2474 C ILE B 130 -48. 668 -42. 238 9. 955 1. 00 72. 40 CATOM 2474 C ILE B 130 -48. 668 -42. 238 9. 955 1. 00 72. 40 C
ATOM 2475 0 ILE B 130 -49. 336 -41. 338 9. 445 1. 00 72. 82 0ATOM 2475 0 ILE B 130 -49. 336 -41. 338 9. 445 1. 00 72. 82 0
ATOM 2476 N ASP B 131 -47. 868 - 42. 035 10. 998 1. 00 72. 22 NATOM 2476 N ASP B 131 -47. 868-42. 035 10. 998 1. 00 72. 22 N
ATOM 2477 CA ASP B 131 -47. 601 - 40. 690 11. 502 1. 00 71. 60 CATOM 2477 CA ASP B 131 -47. 601-40. 690 11. 502 1. 00 71. 60 C
ATOM 2478 CB ASP B 131 -46. 905 -40. 763 12. 861 1. 00. 73. 63 CATOM 2478 CB ASP B 131 -46. 905 -40. 763 12. 861 1. 00. 73. 63 C
ATOM 2479 CG ASP B 131 -45. 654 -41. 620 12. 826 1. 00 75. 80 CATOM 2479 CG ASP B 131 -45. 654 -41. 620 12. 826 1. 00 75. 80 C
ATOM 2480 0D1 ASP B 131 一 44. 647 -41. 233 13. 458 1. 00 77. 30 0ATOM 2480 0D1 ASP B 131 1 44. 647 -41. 233 13. 458 1. 00 77. 30 0
ATOM 2481 0D2 ASP B 131 -45. 678 -42. 682 12. 165 1. 00 77. 06 0ATOM 2481 0D2 ASP B 131 -45. 678 -42. 682 12. 165 1. 00 77. 06 0
ATOM 2482 C ASP B 131 -46. 707 - 39. 965 10. 503 1. 00 70. 22 CATOM 2482 C ASP B 131 -46. 707-39. 965 10. 503 1. 00 70. 22 C
ATOM 2483 0 ASP B 131 -46. 556 -38. 741 10. 550 1. ,00 70. 54 0ATOM 2483 0 ASP B 131 -46. 556 -38. 741 10. 550 1., 00 70. 54 0
ATOM 2484 N GLU B 132 -46. 115 - 40. 746 9. 602 1. ,00 66. 98 NATOM 2484 N GLU B 132 -46. 115-40. 746 9. 602 1., 00 66. 98 N
ATOM 2485 CA GLU B 132 -45. 332 -40. 231 8. 486 1. 00 62. 77 CATOM 2485 CA GLU B 132 -45. 332 -40. 231 8. 486 1. 00 62. 77 C
ATOM 2486 CB GLU B 132 -44. 953 -41. 392 7. 561 1. 00 59. 87 CATOM 2486 CB GLU B 132 -44. 953 -41. 392 7. 561 1. 00 59. 87 C
ATOM 2487 CG GLU B 132 -44. 465 -40. 994 6. 180 1. ,00 57. 42 CATOM 2487 CG GLU B 132 -44. 465 -40. 994 6. 180 1., 00 57. 42 C
ATOM 2488 CD GLU B 132 一 44. 361 -42. 184 5. 239 1. ,00 55. 62 CATOM 2488 CD GLU B 132 1 44. 361 -42. 184 5. 239 1., 00 55. 62 C
ATOM 2489 0E1 GLU B 132 -45. 169 -42. 271 4. 288 1. ,00 54. 56 0ATOM 2489 0E1 GLU B 132 -45. 169 -42. 271 4. 288 1., 00 54. 56 0
ATOM 2490 0E2 GLU B 132 -43. 473 -43. 033 5. 451 1. .00 53. 47 0ATOM 2490 0E2 GLU B 132 -43. 473 -43. 033 5. 451 1. .00 53. 47 0
ATOM 2491 C GLU B 132 -46. 126 -39. 179 7. 716 1. ,00 61. 53 CATOM 2491 C GLU B 132 -46. 126 -39. 179 7. 716 1., 00 61. 53 C
ATOM 2492 0 GLU B 132 -47. 278 -39. 402 7. 356 1. , 00 62. 53 0ATOM 2492 0 GLU B 132 -47. 278 -39. 402 7. 356 1., 00 62. 53 0
ATOM 2493 N ARG B 133 -45. 511 -38. 029 7. 470 1. .00 60. 43 NATOM 2493 N ARG B 133 -45. 511 -38. 029 7. 470 1. .00 60. 43 N
ATOM 2494 CA ARG B 133 -46. 192 -36. 952 6. 766 1. .00 59. 77 CATOM 2494 CA ARG B 133 -46. 192 -36. 952 6. 766 1. .00 59. 77 C
ATOM 2495 CB ARG B 133 -45. 635一 35. 594 7. 202 1. .00 61. 40 C ATOM 2496 CG ARG B 133 -46.341 -34.406 6.557 1.00 65.29 CATOM 2495 CB ARG B 133 -45. 635 1 35. 594 7. 202 1. .00 61. 40 C ATOM 2496 CG ARG B 133 -46.341 -34.406 6.557 1.00 65.29 C
ATOM 2497 CD ARG B 133 -45. 443 -33. 174 6. 490 1. 00 68. 49 CATOM 2497 CD ARG B 133 -45. 443 -33. 174 6. 490 1. 00 68. 49 C
ATOM 2498 NE ARG B 133 -45. 289 -32. 529 7. 793 1. 00 71. 01 NATOM 2498 NE ARG B 133 -45. 289 -32. 529 7. 793 1. 00 71. 01 N
ATOM 2499 CZ ARG B 133 一 44. 420 -31. 555 8. 049 1. 00 71. 63 CATOM 2499 CZ ARG B 133 1 44. 420 -31. 555 8. 049 1. 00 71. 63 C
ATOM 2500 NH1 ARG B 133 -43. 620 -31. 108 7. 089 1. 00 71. 15 NATOM 2500 NH1 ARG B 133 -43. 620 -31. 108 7. 089 1. 00 71. 15 N
ATOM 2501 NH2 ARG B 133 -44. 351 -31. 031 9. 266 1. 00 71. 39 NATOM 2501 NH2 ARG B 133 -44. 351 -31. 031 9. 266 1. 00 71. 39 N
ATOM 2502 C ARG B 133 - 46. 059 -37. 102 5. 248 1. 00 57. 92 CATOM 2502 C ARG B 133-46. 059 -37. 102 5. 248 1. 00 57. 92 C
ATOM 2503 0 ARG B 133 -46. 905 -36. 616 4. 491 1. 00 58. 36 0ATOM 2503 0 ARG B 133 -46. 905 -36. 616 4. 491 1. 00 58. 36 0
ATOM 2504 N MET B 134 -45. 000 -37. 773 4. 805 1. 00 53. 71 NATOM 2504 N MET B 134 -45. 000 -37. 773 4. 805 1. 00 53. 71 N
ATOM 2505 CA MET B 134 -44. 758 -37. 950 3. 377 1. 00 49. 10 CATOM 2505 CA MET B 134 -44. 758 -37. 950 3. 377 1. 00 49. 10 C
ATOM 2506 CB MET B 134 -44. 330 - 36. 624 2. 747 1. 00 50. 32 CATOM 2506 CB MET B 134 -44. 330-36. 624 2. 747 1. 00 50. 32 C
ATOM 2507 CG MET B 134 - 43. 987 - 36. 719 1. 272 1. 00 51. 15 CATOM 2507 CG MET B 134-43. 987-36. 719 1. 272 1. 00 51. 15 C
ATOM 2508 SD MET B 134 -43. 387 -35. 154 0. 623 1. 00 54. 92 SATOM 2508 SD MET B 134 -43. 387 -35. 154 0. 623 1. 00 54. 92 S
ATOM 2509 CE MET B 134 -44. 776 -34. 086 0. 975 1. 00 55. 01 CATOM 2509 CE MET B 134 -44. 776 -34. 086 0. 975 1. 00 55. 01 C
ATOM 2510 C MET B 134 -43. 706 -39. 012 3. 082 1. 00 46. 57 CATOM 2510 C MET B 134 -43. 706 -39. 012 3. 082 1. 00 46. 57 C
ATOM 2511 0 MET B 134 -42. 733 -39. 177 3. 818 1. 00 45. 15 0ATOM 2511 0 MET B 134 -42. 733 -39. 177 3. 818 1. 00 45. 15 0
ATOM 2512 N ALA B 135 -43. 917 -39. 738 1. 993 1. 00 44. 38 NATOM 2512 N ALA B 135 -43. 917 -39. 738 1. 993 1. 00 44. 38 N
ATOM 2513 CA ALA B 135 -42. 929 -40. 690 1. 512 1. 00 40. 96 CATOM 2513 CA ALA B 135 -42. 929 -40. 690 1. 512 1. 00 40. 96 C
ATOM 2514 CB ALA B 135 -43. 543 -42. 085 1. 443 1. 00 40. 18 CATOM 2514 CB ALA B 135 -43. 543 -42. 085 1. 443 1. 00 40. 18 C
ATOM 2515 C ALA B 135 -42. 435 -40. 261 0. 133 1. 00 38. 54 CATOM 2515 C ALA B 135 -42. 435 -40. 261 0. 133 1. 00 38. 54 C
ATOM 2516 0 ALA B 135 - 43. 230 -39. 930 -0. 747 1. 00 36. 00 0ATOM 2516 0 ALA B 135-43. 230 -39. 930 -0. 747 1. 00 36. 00 0
ATOM 2517 N LEU B 136 -41. 117 - 40. 258 -0. 037 1. 00 36. 64 NATOM 2517 N LEU B 136 -41. 117-40. 258 -0. 037 1. 00 36. 64 N
ATOM 2518 CA LEU B 136 -40. 503 -40. 033 -r. 335 1. 00 34. 81 CATOM 2518 CA LEU B 136 -40. 503 -40. 033 -r. 335 1. 00 34. 81 C
ATOM 2519 CB LEU B 136 -39. 441 - 38. 933 - 1. 247 1. 00 36. 45 CATOM 2519 CB LEU B 136 -39. 441-38. 933-1. 247 1. 00 36. 45 C
ATOM 2520 CG LEU B 136 - 39. 851 -37. 456 -1. 291 1. 00 37. 42 CATOM 2520 CG LEU B 136-39. 851 -37. 456 -1. 291 1. 00 37. 42 C
ATOM 2521 CD1 LEU B 136 - 40. 826 -37. 145 - 0. 170 1. ,00 38. 59 CATOM 2521 CD1 LEU B 136-40. 826 -37. 145-0. 170 1., 00 38. 59 C
ATOM 2522 CD2 LEU B 136 - 38. 605 -36. 586 -1. 167 1. ,00 35. 58 CATOM 2522 CD2 LEU B 136-38. 605 -36. 586 -1. 167 1., 00 35. 58 C
ATOM 2523 C LEU B 136 -39. 846 -41. 325 -1. 806 1. 00 33. 98 CATOM 2523 C LEU B 136 -39. 846 -41. 325 -1. 806 1. 00 33. 98 C
ATOM 2524 0 LEU B 136 -38. 806 -41. 725 - 1. 290 1. 00 34. 24 0ATOM 2524 0 LEU B 136 -38. 806 -41. 725-1. 290 1. 00 34. 24 0
ATOM 2525 N ILE B 137 -40. 455 -41. 980 - 2. 783 1. ,00 31. 92 NATOM 2525 N ILE B 137 -40. 455 -41. 980-2. 783 1., 00 31. 92 N
ATOM 2526 CA ILE B 137 - 39. 832 -43. 133 -3. 400 1. ,00 31. 29 CATOM 2526 CA ILE B 137-39. 832 -43. 133 -3. 400 1., 00 31. 29 C
ATOM 2527 CB ILE B 137 -40. 889 -44. 129 -3. 904 1. 00 33. 59 CATOM 2527 CB ILE B 137 -40. 889 -44. 129 -3. 904 1. 00 33. 59 C
ATOM 2528 CG2 ILE B 137 -42. 239 -43. 472 - 3. 937 1. ,00 34. 15 CATOM 2528 CG2 ILE B 137 -42. 239 -43. 472-3. 937 1., 00 34. 15 C
ATOM 2529 CG1 ILE B 137 -40. 472 -44. 686 -5. 262 1. ,00 32. 49 CATOM 2529 CG1 ILE B 137 -40. 472 -44. 686 -5. 262 1., 00 32. 49 C
ATOM 2530 CD1 ILE B 137 -41. 572 -45. 410 -5. 977 1. 00 38. 85 CATOM 2530 CD1 ILE B 137 -41. 572 -45. 410 -5. 977 1. 00 38. 85 C
ATOM 2531 C ILE B 137 -38. 943 -42. 689 -4. 551 1. 00 29. 71 C ATOM 2532 0 I LE B 137 -39. 289 -41. 782 - 5. 308 1 . 00 30. 57 0ATOM 2531 C ILE B 137 -38. 943 -42. 689 -4. 551 1. 00 29. 71 C ATOM 2532 0 I LE B 137 -39. 289 -41. 782-5. 308 1. 00 30. 57 0
ATOM 2533 N VAL B 138 -37. 775 -43. 308 -4. 655 1 . 00 27. 97 NATOM 2533 N VAL B 138 -37. 775 -43. 308 -4.655 1 .00 27. 97 N
ATOM 2534 CA VAL B 138 -36. 822 -42. 937 - 5. 687 1 . 00 27. 35 CATOM 2534 CA VAL B 138 -36. 822 -42. 937-5. 687 1. 00 27. 35 C
ATOM 2535 CB VAL B 138 -35. 598 -42. 196 -5. 078 1. 00 27. 61 CATOM 2535 CB VAL B 138 -35. 598 -42. 196 -5. 078 1. 00 27. 61 C
ATOM 2536 CG1 VAL B 138 -36. 063 -40. 902 -4. 399 1 . 00 28. 30 CATOM 2536 CG1 VAL B 138 -36. 063 -40. 902 -4. 399 1. 00 28. 30 C
ATOM 2537 CG2 VAL B 138 - 34. 890 -43. 079 -4. 067 1 . 00 26. 90 CATOM 2537 CG2 VAL B 138-34. 890 -43. 079 -4. 067 1. 00 26. 90 C
ATOM 2538 C VAL B 138 -36. 359 -44. 161 -6. 462 1. 00 27. 69 CATOM 2538 C VAL B 138 -36. 359 -44. 161 -6. 462 1. 00 27. 69 C
ATOM 2539 0 VAL B 138 -36. 015 - 45. 186 - 5. 878 1. 00 27. 45 0ATOM 2539 0 VAL B 138 -36. 015-45. 186-5. 878 1. 00 27. 45 0
ATOM 2540 N ASP B 139 -36. 367 -44. 038 - 7. 785 1. 00 28. 37 NATOM 2540 N ASP B 139 -36. 367 -44. 038-7. 785 1. 00 28. 37 N
ATOM 2541 CA ASP B 139 -35. 974 -45. 108 - 8. 697 1 . 00 28. 70 CATOM 2541 CA ASP B 139 -35. 974 -45. 108-8. 697 1.00 00.70 C
ATOM 2542 CB ASP B 139 -37. 145 -46. 076 -8. 898 1. 00 30. 23 CATOM 2542 CB ASP B 139 -37. 145 -46. 076 -8. 898 1. 00 30. 23 C
ATOM 2543 CG ASP B 139 -36. 703 -47. 460 - 9. 338 1 . 00 31 . 25 CATOM 2543 CG ASP B 139 -36. 703 -47. 460-9. 338 1. 00 31 .25 C
ATOM 2544 0D1 ASP B 139 -35. 504 -47. 784 -9. 209 1 . 00 34. 28 0ATOM 2544 0D1 ASP B 139 -35. 504 -47. 784 -9. 209 1 .00 34. 28 0
ATOM 2545 0D2 ASP B 139 - 37. 565 -48. 232 - 9. 810 1. 00 32. 48 0ATOM 2545 0D2 ASP B 139-37. 565 -48. 232-9. 810 1. 00 32. 48 0
ATOM 2546 C ASP B 139 -35. 650 -44. 400 -10. 011 1 . 00 30. 00 CATOM 2546 C ASP B 139 -35. 650 -44. 400 -10. 011 1. 00 30. 00 C
ATOM 2547 0 ASP B 139 -36. 452 -43. 606 -10. 506 1 . 00 28. 15 0ATOM 2547 0 ASP B 139 -36. 452 -43. 606 -10. 506 1. 00 28. 15 0
ATOM 2548 N PRO B 140 -34. 465 -44. 664 -10. 585 1 . 00 29. 89 NATOM 2548 N PRO B 140 -34. 465 -44. 664 -10. 585 1. 00 29. 89 N
ATOM 2549 CD PRO B 140 - 33. 429 -45. 569 - 10. 064 1 . 00 29. 98 CATOM 2549 CD PRO B 140-33. 429 -45. 569-10. 064 1. 00 29. 98 C
ATOM . 2550 CA PRO B 140 -33. 983 -43. 892 -1 1. 738 1. 00 30. 27 CATOM. 2550 CA PRO B 140 -33. 983 -43. 892 -1 1. 738 1. 00 30. 27 C
ATOM 2551 CB PRO B 140 -32. 602 -44. 486 -12. 015 1 . 00 30. 85 CATOM 2551 CB PRO B 140 -32. 602 -44. 486 -12. 015 1 .00 30. 85 C
ATOM 2552 CG PRO B 140 -32. 174 -45. 042 -10. 701 1. 00 29. 97 CATOM 2552 CG PRO B 140 -32. 174 -45. 042 -10. 701 1. 00 29. 97 C
ATOM 2553 C PRO B 140 -34. 879 -43. 930 - 12. 977 1 . , 00 31 . 19 CATOM 2553 C PRO B 140 -34. 879 -43. 930-12. 977 1., 00 31 .19 C
ATOM 2554 0 PRO B 140 -35. 003 -42. 930 -13. 688 1 . 00 30. 88 0ATOM 2554 0 PRO B 140 -35. 003 -42. 930 -13. 688 1. 00 30. 88 0
ATOM 2555 -N MET B 141 - 35. 502 -45. 074 -13. 240 1. 00 31. 42 NATOM 2555 -N MET B 141-35. 502 -45. 074 -13. 240 1. 00 31. 42 N
ATOM 2556 CA MET B 141 -36. 238 -45. 249 -14. 488 1 . . 00 32. 43 CATOM 2556 CA MET B 141 -36. 238 -45. 249 -14. 488 1.. 00 32. 43 C
ATOM 2557 CB MET B 141 -35. 508 -46. 238 -15. 395 1 . 00 34. 66 CATOM 2557 CB MET B 141 -35. 508 -46. 238 -15. 395 1. 00 34. 66 C
ATOM 2558 CG MET B 141 -34. 049 -45. 915 -15. 615 1. , 00 36. 71 ' CATOM 2558 CG MET B 141 -34. 049 -45. 915 -15. 615 1., 00 36. 71 'C
ATOM 2559 SD MET B 141 -33. 265 -47. 139 - 16. 653 1 . , 00 43. 43 SATOM 2559 SD MET B 141 -33. 265 -47. 139-16. 653 1., 00 43. 43 S
ATOM 2560 CE MET B 141 -33. 688 -48. 651 -15. 762 1 . , 00 39. 34 CATOM 2560 CE MET B 141 -33. 688 -48. 651 -15. 762 1., 00 39. 34 C
ATOM 2561 C MET B 141 -37. 657 -45. 743 -14. 266 1. , 00 32. 89 GATOM 2561 C MET B 141 -37. 657 -45. 743 -14. 266 1., 00 32. 89 G
ATOM 2562 0 MET B 141 -37. 878 -46. 761 - 13. 609 1 . , 00 32. 77 0ATOM 2562 0 MET B 141 -37. 878 -46. 761-13. 609 1., 00 32. 77 0
ATOM 2563 N LEU B 142 -38. 617 -45. 016 -14. 827 1 . . 00 33. 05 NATOM 2563 N LEU B 142 -38. 617 -45. 016 -14. 827 1.. 00 33. 05 N
ATOM 2564 CA LEU B 142 -39. 999 -45. 467 -14. 873 1. , 00 31 . 54 CATOM 2564 CA LEU B 142 -39. 999 -45. 467 -14. 873 1., 00 31 .54 C
ATOM 2565 CB LEU B 142 -40. 936 - 44. 310 -14. 530 1. . 00 30. 61 CATOM 2565 CB LEU B 142 -40. 936-44. 310 -14. 530 1.. 00 30. 61 C
ATOM 2566 CG LEU B 142 - 42. 389 —44. 667 -14. 222 1 . , 00 30. 06 CATOM 2566 CG LEU B 142-42. 389 —44. 667 -14. 222 1., 00 30. 06 C
ATOM 2567 CD1 LEU B 142 一 42. 493 -45. 064 -12. 772 1. , 00 29. 44 C ATOM 2568 CD2 LEU B 142 -43.299 - 43.479 -14.502 1.00 30.45 CATOM 2567 CD1 LEU B 142 1 42. 493 -45. 064 -12. 772 1., 00 29. 44 C ATOM 2568 CD2 LEU B 142 -43.299-43.479 -14.502 1.00 30.45 C
ATOM 2569 C LEU B 142 -40.288 -45.964 -16. 291 1. 00 31. 52 CATOM 2569 C LEU B 142 -40.288 -45.964 -16. 291 1. 00 31. 52 C
ATOM 2570 0 LEU B 142 - 40.630 - 45.174 -17. 177 1. 00 32.12 0ATOM 2570 0 LEU B 142-40.630-45.174 -17. 177 1. 00 32.12 0
ATOM 2571 N ALA B 143 -40.146 -47. 267 -16. 505 1. 00 30.78 NATOM 2571 N ALA B 143 -40.146 -47. 267 -16. 505 1. 00 30.78 N
ATOM 2572 CA ALA B 143 -40.347 - 47. 836 -17. 831 1. 00 33.20 CATOM 2572 CA ALA B 143 -40.347-47. 836 -17. 831 1. 00 33.20 C
ATOM 2573 CB ALA B 143 -39.432 -49. 041 -18. 025 1. 00 32.10 CATOM 2573 CB ALA B 143 -39.432 -49. 041 -18. 025 1. 00 32.10 C
ATOM 2574 C ALA B 143 -41. 811 -48. 235 -18. 024 1. 00 34.76 CATOM 2574 C ALA B 143 -41. 811 -48. 235 -18. 024 1. 00 34.76 C
ATOM 2575 0 ALA B 143 - 42.569 - 47. 528 -18. 685 1. 00 35.78 0ATOM 2575 0 ALA B 143-42.569-47. 528 -18. 685 1. 00 35.78 0
ATOM 2576 N THR B 144 -42.209 -49. 359 -17. 434 1. 00 36.69 NATOM 2576 N THR B 144 -42.209 -49. 359 -17. 434 1. 00 36.69 N
ATOM 2577 CA THR B 144 - 43. 609 -49. 773 -17. 447 1. 00 38.00 CATOM 2577 CA THR B 144-43. 609 -49. 773 -17. 447 1. 00 38.00 C
ATOM 2578 CB THR B 144 - 43. 746 -51. 305 -17. 447 1. 00 39. 26 CATOM 2578 CB THR B 144-43. 746 -51. 305 -17. 447 1. 00 39. 26 C
ATOM 2579 061 THR B 144 -43. 054 -51. 839 -16. 315 1. 00 41. 81 0ATOM 2579 061 THR B 144 -43. 054 -51. 839 -16. 315 1. 00 41. 81 0
ATOM 2580 CG2 THR B 144 -43. 162 -51. 902 - 18. 721 1. 00 39. 32 . GATOM 2580 CG2 THR B 144 -43. 162 -51. 902-18. 721 1. 00 39. 32.
ATOM 2581 C THR B 144 -44. 313 -49. 238 -16. 214 1. 00 38. 48 CATOM 2581 C THR B 144 -44. 313 -49. 238 -16. 214 1. 00 38. 48 C
ATOM 2582 0 THR B 144 -45. 526一 49. 033 -16. 218 1. 00 39. 62 0ATOM 2582 0 THR B 144 -45. 526 1 49. 033 -16. 218 1. 00 39. 62 0
ATOM 2583 N GLY B 145 -43. 544一 49. 014 -15. 155 1. 00 39. 36 NATOM 2583 N GLY B 145 -43. 544 1 49. 014 -15. 155 1. 00 39. 36 N
ATOM 2584 CA GLY B 145 -44. 110 -48. 480 -13. 931 1. 00 38. 58 CATOM 2584 CA GLY B 145 -44. 110 -48. 480 -13. 931 1. 00 38. 58 C
ATOM 2585 C GLY B 145 -44. 474 -49. 566 -12. 940 1. 00 38. 26 CATOM 2585 C GLY B 145 -44. 474 -49. 566 -12. 940 1. 00 38. 26 C
ATOM 2586 0 GLY B 145 -45. 102 -49. 301 -11. 921 1. 00 37. 88 0ATOM 2586 0 GLY B 145 -45. 102 -49. 301 -11. 921 1. 00 37. 88 0
ATOM 2587 N GLY B 146 -44. 070 -50. 794 -13. 240 1. 00 38. 60 NATOM 2587 N GLY B 146 -44. 070 -50. 794 -13. 240 1. 00 38. 60 N
ATOM 2588 CA GLY B 146 -44. 402 -51. 910 -12. 376 1. 00 38. 58 CATOM 2588 CA GLY B 146 -44. 402 -51. 910 -12. 376 1. 00 38. 58 C
ATOM 2589 C GLY B 146 -43. 873 -51. 746 -10. 969 1. 00 38. 23 CATOM 2589 C GLY B 146 -43. 873 -51. 746 -10. 969 1. 00 38. 23 C
ATOM 2590 0 GLY B 146 -44. 630 -51. 772 -10.009 1. 00 39. 98 0ATOM 2590 0 GLY B 146 -44. 630 -51. 772 -10.009 1. 00 39. 98 0
ATOM 2591 N SER B 147 - 42. 564 -51. 573 -10. 847 1. ,00 40. 40 NATOM 2591 N SER B 147-42. 564 -51. 573 -10. 847 1., 00 40. 40 N
ATOM 2592 CA SER B 147 - 41. 926 -51. 420 -9. 545 1. .00 39. 49 CATOM 2592 CA SER B 147-41. 926 -51. 420 -9. 545 1. .00 39. 49 C
ATOM 2593 CB SER B 147 -40. 434 - 51. 160 -9. 725 1. .00 39. 92 CATOM 2593 CB SER B 147 -40. 434-51. 160 -9. 725 1. .00 39. 92 C
ATOM 2594 06 SER B 147 -39. 864 - 52. 106 -10. 605 1. ,00 43. 98 0ATOM 2594 06 SER B 147 -39. 864-52. 106 -10. 605 1., 00 43. 98 0
ATOM 2595 C SER B 147 - 42. 540 -50. 274 -8. 747 1. ,00 39. 09 CATOM 2595 C SER B 147-42. 540 -50. 274 -8. 747 1., 00 39. 09 C
ATOM 2596 0 SER B 147 -42. 827 -50. 422 -7. 559 1. ,00 39. 36 0ATOM 2596 0 SER B 147 -42. 827 -50. 422 -7. 559 1., 00 39. 36 0
ATOM 2597 N VAL B 148 -42. 742 -49. 133 -9. 397 1. ,00 37. 83 NATOM 2597 N VAL B 148 -42. 742 -49. 133 -9. 397 1., 00 37. 83 N
ATOM 2598 CA VAL B 148 -43. 230 -47. 951 -8. 692 1. .00 36. 73 CATOM 2598 CA VAL B 148 -43. 230 -47. 951 -8. 692 1. .00 36. 73 C
ATOM 2599 CB VAL B 148 - 43. 264 -46. 703 -9. 622 1. .00 37. 02 CATOM 2599 CB VAL B 148-43. 264 -46. 703 -9. 622 1. .00 37. 02 C
ATOM 2600 CG1 VAL B 148 -44. 254 -46. 915 -10. 748 1. .00 39. 45 CATOM 2600 CG1 VAL B 148 -44. 254 -46. 915 -10. 748 1. .00 39. 45 C
ATOM 2601 GG2 VAL B 148 -43. 644 - 45. 471 -8. 831 1. .00 37. 05 CATOM 2601 GG2 VAL B 148 -43. 644-45. 471 -8. 831 1. .00 37. 05 C
ATOM 2602 C VAL B 148 -44. 626 -48. 212 - 8. 149 1. .00 35. 22 CATOM 2602 C VAL B 148 -44. 626 -48. 212-8. 149 1. .00 35. 22 C
ATOM 2603 0 VAL B 148 -44. 926一 47.902 一 6. 993 1, .00 34. 22 0 ATOM 2604 N ILE B 149 -45.475 -48.801 - 8.982 1.00 34.77 NATOM 2603 0 VAL B 148 -44. 926 one 47.902 one 6. 993 1, .00 34. 22 0 ATOM 2604 N ILE B 149 -45.475 -48.801-8.982 1.00 34.77 N
ATOM 2605 CA ILE B 149 -46.869 -49.020 -8.611 1. 00 36.00 CATOM 2605 CA ILE B 149 -46.869 -49.020 -8.611 1. 00 36.00 C
ATOM 2606 CB ILE B 149 -47.686 -49.566 -9.814 1. 00 35.79 CATOM 2606 CB ILE B 149 -47.686 -49.566 -9.814 1. 00 35.79 C
ATOM 2607 CG2 ILE B 149 -49.086 - 49.938 -9.376 1. 00 36.33 CATOM 2607 CG2 ILE B 149 -49.086-49.938 -9.376 1. 00 36.33 C
ATOM 2608 CG1 ILE B 149 -47.742 -48.502 - 10.916 1. 00 35.31 CATOM 2608 CG1 ILE B 149 -47.742 -48.502-10.916 1. 00 35.31 C
ATOM 2609 CD1 ILE B 149 -48.451 - 48.946 -12.174 1. 00 34.66 CATOM 2609 CD1 ILE B 149 -48.451-48.946 -12.174 1.00 34.66 C
ATOM 2610 C ILE B 149 - 46.992 -49.975 -7.427 1. 00 34.41 CATOM 2610 C ILE B 149-46.992 -49.975 -7.427 1. 00 34.41 C
ATOM 2611 0 ILE B 149 - 47.761 -49.730 - 6.499 1. 00 33.92 0ATOM 2611 0 ILE B 149-47.761 -49.730-6.499 1. 00 33.92 0
ATOM 2612 N ALA B 150 - 46.213 - 51. 047 -7, 446 1. 00 34.17 NATOM 2612 N ALA B 150-46.213-51. 047 -7, 446 1. 00 34.17 N
ATOM 2613 CA ALA B 150 -46.280 -52.038 -6.387 1. 00 35.05 CATOM 2613 CA ALA B 150 -46.280 -52.038 -6.387 1. 00 35.05 C
ATOM 2614 CB ALA B 150 -45.500 - 53.273 - 6.791 1. 00 35. 14 CATOM 2614 CB ALA B 150 -45.500-53.273-6.791 1. 00 35. 14 C
ATOM 2615 ,C ALA B 150 - 45.752 -51. 490 -5.061 1. 00 36. 06 CATOM 2615, C ALA B 150-45.752 -51.490 -5.061 1.00 36.06 C
ATOM 2616 0 ALA B 150 -46.267 -51. 828 - 3.993 1. 00 37. 15 0ATOM 2616 0 ALA B 150 -46.267 -51. 828-3.993 1. 00 37. 15 0
ATOM 2617 N THR B 151 - 44.723 -50. 649 - 5.132 1. 00 35. 00 NATOM 2617 N THR B 151-44.723 -50. 649-5.132 1. 00 35. 00 N
ATOM 2618 CA THR B 151 -44.159 -50. 029 -3.938 1. 00 32. 95 CATOM 2618 CA THR B 151 -44.159 -50. 029 -3.938 1. 00 32. 95 C
ATOM 2619 CB THR B 151 -42.867 - 49. 247 -4.267 1. 00 31. 48 GATOM 2619 CB THR B 151 -42.867-49. 247 -4.267 1. 00 31. 48 G
ATOM 2620 0G1 THR B 151 - 41.920 -50. 124 -4.887 1. ,00 28. 33 0ATOM 2620 0G1 THR B 151-41.920 -50. 124 -4.887 1., 00 28. 33 0
ATOM 2621 CG2 THR B 151 -42.256 -48. 672 -3.000 1. ,00 32. 45 CATOM 2621 CG2 THR B 151 -42.256 -48. 672 -3.000 1., 00 32. 45 C
ATOM 2622 C THR B 151 -45.178 - 49. 065 -3.340 1. .00 33. 42 CATOM 2622 C THR B 151 -45.178-49. 065 -3.340 1. .00 33. 42 C
ATOM 2623 0 THR B 151 -45.296 -48. 946 -2.126 1. ,00 33. 61 0ATOM 2623 0 THR B 151 -45.296 -48. 946 -2.126 1., 00 33. 61 0
ATOM 2624 N ILE B 152 - 45.921 - 48. 382 -4.203 1. ,00 34. 63 ATOM 2624 N ILE B 152-45.921-48. 382 -4.203 1., 00 34. 63
ATOM 2625 CA ILE B 152 -46.988 -47. 498 -3.748 1. .00 34. 29 C ATOM 2625 CA ILE B 152 -46.988 -47. 498 -3.748 1. .00 34. 29 C
ATOM 2626 CB ILE B 152 -47.614 -46. 733 -4.935 1. .00 33. 44 CATOM 2626 CB ILE B 152 -47.614 -46. 733 -4.935 1. .00 33. 44 C
ATOM 2627 C62 ILE B 152 -48.819 -45. 921 - 4.475 1. .00 30. 41 CATOM 2627 C62 ILE B 152 -48.819 -45. 921-4.475 1. .00 30. 41 C
ATOM 2628 CG1 ILE B 152 -46.563 -45. 811 - 5.558 1. .00 30. 09 CATOM 2628 CG1 ILE B 152 -46.563 -45. 811-5.558 1. .00 30. 09 C
ATOM 2629 CD1 ILE B 152 - 47.023 -45. 154 -6.832 1, .00 33. 63 CATOM 2629 CD1 ILE B 152-47.023 -45. 154 -6.832 1, .00 33. 63 C
ATOM 2630 C ILE B 152 -48.061 -48. 316 - 3.040 1, .00 36. 62 CATOM 2630 C ILE B 152 -48.061 -48. 316-3.040 1, .00 36. 62 C
ATOM 2631 0 ILE B 152 -48.560 -47. 918 -1.985 1, .00 37. 49 0ATOM 2631 0 ILE B 152 -48.560 -47. 918 -1.985 1, .00 37. 49 0
ATOM 2632 N ASP B 153 -48.398 -49. 470 -3.610 1, .00 37. 08 NATOM 2632 N ASP B 153 -48.398 -49. 470 -3.610 1, .00 37. 08 N
ATOM 2633 CA ASP B 153 -49.319 -50. 393 - 2.957 1 .00 37. 64 CATOM 2633 CA ASP B 153 -49.319 -50. 393-2.957 1 .00 37. 64 C
ATOM 2634 CB ASP B 153 -49.481 -51. 678 -3.787 1, .00 37. 48 CATOM 2634 CB ASP B 153 -49.481 -51. 678 -3.787 1, .00 37. 48 C
ATOM 2635 C6 ASP B 153 -50.224 -51. 453 - 5.102 1, .00 38. 86 CATOM 2635 C6 ASP B 153 -50.224 -51. 453-5.102 1, .00 38. 86 C
ATOM 2636 0D1 ASP B 153 -51■ 050 -50. 518 - 5.197 1 .00 39. 46 0ATOM 2636 0D1 ASP B 153 -51 050 -50. 518-5.197 1 .00 39. 46 0
ATOM 263フ 0D2 ASP B 153 -49.981 -52. 229 -6.050 1 .00 40. 55 0ATOM 263F 0D2 ASP B 153 -49.981 -52. 229 -6.050 1 .00 40. 55 0
ATOM 2638 C ASP B 153 -48.792 - 50. 751 -1.563 1 • 00 37. 97 CATOM 2638 C ASP B 153 -48.792-50. 751 -1.563 1 • 00 37. 97 C
ATOM 2639 0 ASP B 153 -49.507 -50. 634 一 0.574 1 .00 39. 02 0 ATOM 2640 N LEU B 154 -47.539 -51.183 -1.488 1.00 38.46 NATOM 2639 0 ASP B 153 -49.507 -50. 634 1 0.574 1 .00 39. 02 0 ATOM 2640 N LEU B 154 -47.539 -51.183 -1.488 1.00 38.46 N
ATOM 2641 CA LEU B 154 -46.949 -51. 580 -0.212 1. 00 38.58 CATOM 2641 CA LEU B 154 -46.949 -51. 580 -0.212 1. 00 38.58 C
ATOM 2642 CB LEU B 154 -45.501 -52.024 -0.419 1. 00 37.96 CATOM 2642 CB LEU B 154 -45.501 -52.024 -0.419 1.00 37.96 C
ATOM 2643 CG LEU B 154 -44.778 -52.490 0.845 1. 00 38.56 CATOM 2643 CG LEU B 154 -44.778 -52.490 0.845 1. 00 38.56 C
ATOM 2644 CD1 LEU B 154 -45.235 - 53.900 1. 190 1. 00 38.92 CATOM 2644 CD1 LEU B 154 -45.235-53.900 1. 190 1.00 38.92 C
ATOM 2645 CD2 LEU B 154 -43.274 - 52.449 0.631 1. 00 37.15 CATOM 2645 CD2 LEU B 154 -43.274-52.449 0.631 1. 00 37.15 C
ATOM 2646 C LEU B 154 -46.994 -50.440 0.809 1. 00 38.40 CATOM 2646 C LEU B 154 -46.994 -50.440 0.809 1. 00 38.40 C
ATOM 2647 0 LEU B 154 一 47.463 -50.617 1. 933 1. 00 39.11 0ATOM 2647 0 LEU B 154 1 47.463 -50.617 1. 933 1. 00 39.11 0
ATOM 2648 N LEU B 155 -46.516 -49.267 0. 414 1. 00 38.83 NATOM 2648 N LEU B 155 -46.516 -49.267 0. 414 1. 00 38.83 N
ATOM 2649 CA LEU B 155 -46.505 - 48.121 1. 312 1. 00 39.36 CATOM 2649 CA LEU B 155 -46.505-48.121 1. 312 1. 00 39.36 C
ATOM 2650 CB LEU B 155 - 45.909 -46.898 0. 603 1. 00 38.25 CATOM 2650 CB LEU B 155-45.909 -46.898 0. 603 1. 00 38.25 C
ATOM 2651 ,C6 LEU B 155 -44. 407 -46. 933 0. 292 1. 00 36. 03 CATOM 2651, C6 LEU B 155 -44. 407 -46. 933 0. 292 1. 00 36. 03 C
ATOM 2652 CD1 LEU B 155 -43. 966 -45. 611 -0. 332 1. 00 33. 99 CATOM 2652 CD1 LEU B 155 -43. 966 -45. 611 -0. 332 1. 00 33. 99 C
ATOM 2653 CD2 LEU B 155 -43. 637 -47. 201 1. 571 1. 00 34. 60 CATOM 2653 CD2 LEU B 155 -43. 637 -47. 201 1. 571 1. 00 34. 60 C
ATOM 2654 C LEU B 155 -47. 915 -47. 805 1. 808 1. 00 41. 52 CATOM 2654 C LEU B 155 -47. 915 -47. 805 1. 808 1. 00 41. 52 C
ATOM 2655 0 LEU B 155 —48. 113 -47. 475 2. 978 1. 00 41. 38 0ATOM 2655 0 LEU B 155 --48. 113 -47. 475 2. 978 1. 00 41. 38 0
ATOM 2656 N LYS B 156 -48. 897 -47. 924 0. 920 1. ,00 43. 49 NATOM 2656 N LYS B 156 -48. 897 -47. 924 0. 920 1., 00 43. 49 N
ATOM 2657 CA LYS B 156 -50. 277 -47. 597 1. 262 1. 00 46. 03 CATOM 2657 CA LYS B 156 -50. 277 -47. 597 1. 262 1. 00 46. 03 C
ATOM 2658 CB LYS B 156 -51. 132 -47. 543 - 0. 009 1. .00 44. 69 CATOM 2658 CB LYS B 156 -51. 132 -47. 543-0. 009 1. .00 44. 69 C
ATOM 2659 CG LYS B 156 -50. 872 -46. 307 -0. 856 1. ,00 45. 53 CATOM 2659 CG LYS B 156 -50. 872 -46. 307 -0. 856 1., 00 45. 53 C
ATOM 2660 CD LYS B 156 -51. 903 - 46. 128 -1. 962 1. ,00 45. 73 CATOM 2660 CD LYS B 156 -51. 903-46. 128 -1. 962 1., 00 45. 73 C
ATOM 2661 CE LYS B 156 -51. 723 —44. 781 - 2. 649 1. ,00 45. 94 CATOM 2661 CE LYS B 156 -51. 723 —44. 781-2. 649 1., 00 45. 94 C
ATOM 2662 NZ LYS B 156 -52. 682 -44. 568 - 3. 767 1. ,00 48. 41 NATOM 2662 NZ LYS B 156 -52. 682 -44. 568-3. 767 1., 00 48. 41 N
ATOM 2663 C LYS B 156 -50. 895 - 48. 567 2. 274 1. .00 46. 62 CATOM 2663 C LYS B 156 -50. 895-48. 567 2. 274 1. .00 46. 62 C
ATOM 2664 0 LYS B 156 -51. 561 -48. 148 3. 219 1. ,00 46. 65 0ATOM 2664 0 LYS B 156 -51. 561 -48. 148 3. 219 1., 00 46. 65 0
ATOM 2665 N LYS B 157 -50. 673 - 49. 860 2. 085 1. .00 48. 60 NATOM 2665 N LYS B 157 -50. 673-49. 860 2. 085 1. .00 48. 60 N
ATOM 2666 CA LYS B 157 -51. 166 -50. 837 3. 044 1. .00 50. 61 CATOM 2666 CA LYS B 157 -51. 166 -50. 837 3. 044 1. .00 50. 61 C
ATOM 2667 CB LYS B 157 -50. 803 -52. 254 2. 593 1. ,00 53. 32 CATOM 2667 CB LYS B 157 -50. 803 -52. 254 2. 593 1., 00 53. 32 C
ATOM 2668 CG LYS B 157 -51. 448 - 52. 676 1. 277 1, .00 56. 73 CATOM 2668 CG LYS B 157 -51. 448-52. 676 1. 277 1, .00 56. 73 C
ATOM 2669 CD LYS B 157 -50. 800 -53. 940 0. 709 1. .00 57. 56 CATOM 2669 CD LYS B 157 -50. 800 -53. 940 0. 709 1. .00 57. 56 C
ATOM 2670 CE LYS B 157 -51. 143 -54. 123 -0. 769 1. .00 58. 91 CATOM 2670 CE LYS B 157 -51. 143 -54. 123 -0. 769 1. .00 58. 91 C
ATOM 2671 NZ LYS B 157 - 50. 334 -55. 203 -1. 413 1. .00 59. 58 NATOM 2671 NZ LYS B 157-50. 334 -55. 203 -1. 413 1. .00 59. 58 N
ATOM 2672 C LYS B 157 -50. 546 -50. 549 4. 404 1, .00 50. 45 CATOM 2672 C LYS B 157 -50. 546 -50. 549 4. 404 1, .00 50. 45 C
ATOM 2673 0 LYS B 157 -51. 137 -50. 846 5. 442 1, .00 50. 96 0ATOM 2673 0 LYS B 157 -51. 137 -50. 846 5. 442 1, .00 50. 96 0
ATOM 2674 N ALA B 158 - 49. 355 -49. 958 4. 391 1, .00 49. 55 NATOM 2674 N ALA B 158-49. 355 -49. 958 4. 391 1, .00 49. 55 N
ATOM 2675 CA ALA B 158 -48. 614 -49. 697 5. 619 1, .00 48. 71 C ATOM 2676 CB ALA B 158 -47.114 - 49.734 5.339 1.00 48.58 CATOM 2675 CA ALA B 158 -48. 614 -49. 697 5. 619 1, .00 48. 71 C ATOM 2676 CB ALA B 158 -47.114-49.734 5.339 1.00 48.58 C
ATOM 2677 C ALA B 158 -48.991 -48.369 6.276 1. 00 48.77 CATOM 2677 C ALA B 158 -48.991 -48.369 6.276 1. 00 48.77 C
ATOM 2678 0 ALA B 158 -48.420 - 47.994 7. 300 1. 00 48.92 0ATOM 2678 0 ALA B 158 -48.420-47.994 7.300 1.00 48.92 0
ATOM 2679 N GLY B 159 - 49.944 - 47.654 5.688 1. 00 47.67 NATOM 2679 N GLY B 159-49.944-47.654 5.688 1. 00 47.67 N
ATOM 2680 CA GLY B 159 -50.491 -46.487 6. 357 1. 00 47.73 CATOM 2680 CA GLY B 159 -50.491 -46.487 6. 357 1. 00 47.73 C
ATOM 2681 C GLY B 159 -50.125 -45.148 5. 746 1. 00 47.85 CATOM 2681 C GLY B 159 -50.125 -45.148 5. 746 1. 00 47.85 C
ATOM 2682 0 GLY B 159 -50.642 -44.114 6. 170 1. 00 47.96 0ATOM 2682 0 GLY B 159 -50.642 -44.114 6. 170 1.00 47.96 0
ATOM 2683 N SER B 160 - 49.245 -45.158 4. 749 1. 00 48.18 NATOM 2683 N SER B 160-49.245 -45.158 4. 749 1. 00 48.18 N
ATOM 2684 CA SER B 160 - 48.782 -43.919 4. 134 1. 00 47.78 CATOM 2684 CA SER B 160-48.782 -43.919 4. 134 1. 00 47.78 C
ATOM 2685 CB SER B 160 -47.857 -44.219 2. 951 1. 00 47.86 CATOM 2685 CB SER B 160 -47.857 -44.219 2. 951 1.00 47.86 C
ATOM 2686 OG SER B 160 -46.512 -44.334 3. 380 1. 00 45.45 0ATOM 2686 OG SER B 160 -46.512 -44.334 3. 380 1. 00 45.45 0
ATOM 2687 ,C SER B 160 -49.943 - 43.048 3. 674 1. 00 48.28 . CATOM 2687, C SER B 160 -49.943-43.048 3. 674 1. 00 48.28. C
ATOM 2688 0 SER B 160 -51.044 -43.538 3. 434 1. 00 49.57 0ATOM 2688 0 SER B 160 -51.044 -43.538 3. 434 1. 00 49.57 0
ATOM 2689 N SER B 161 -49.682 -41.751 3. 551 1. 00 48.20 NATOM 2689 N SER B 161 -49.682 -41.751 3. 551 1. 00 48.20 N
ATOM 2690 CA SER B 161 -50.737 -40.762 3. 389 1. 00 47.22 CATOM 2690 CA SER B 161 -50.737 -40.762 3. 389 1. 00 47.22 C
ATOM 2691 CB SER B 161 -50.730 -39.814 4. 589 1. 00 47.92 CATOM 2691 CB SER B 161 -50.730 -39.814 4. 589 1. 00 47.92 C
ATOM 2692 OG SER B 161 - 49.434 -39.747 5. 168 1. ,00 45.91 0ATOM 2692 OG SER B 161-49.434 -39.747 5. 168 1., 00 45.91 0
ATOM 2693 C SER B 161 -50.580 -39.972 2. 095 1. ,00 46.90 CATOM 2693 C SER B 161 -50.580 -39.972 2. 095 1., 00 46.90 C
ATOM 2694 0 SER B 161 - 51 · 485 -39.939 1. 265 1. ,00 48.29 0ATOM 2694 0 SER B 161-51 485 -39.939 1. 265 1., 00 48.29 0
ATOM 2695 N SER B 162 -49.435 -39.326 1. 924 1, ,00 44.22 NATOM 2695 N SER B 162 -49.435 -39.326 1. 924 1,, 00 44.22 N
ATOM 2696 CA SER B 162 -49.134 -38.695 0. 650 1. .00 43.02 CATOM 2696 CA SER B 162 -49.134 -38.695 0. 650 1. .00 43.02 C
ATOM 2697 CB SER B 162 -49.177 -37.170 0. 780 1. .00 43.23 CATOM 2697 CB SER B 162 -49.177 -37.170 0. 780 1. .00 43.23 C
ATOM 2698 OG SER B 162 - 48.216 -36.693 1'.704 1. .00 45.78 0ATOM 2698 OG SER B 162-48.216 -36.693 1'.704 1. .00 45.78 0
ATOM 2699 C SER B 162 -47.773 -39.149 0. 135 1, .00 41.27 CATOM 2699 C SER B 162 -47.773 -39.149 0. 135 1, .00 41.27 C
ATOM 2700 0 SER B 162 -46.757 -39.008 0. 811 1, .00 42.47 0ATOM 2700 0 SER B 162 -46.757 -39.008 0. 811 1, .00 42.47 0
ATOM 2701 N ILE B 163 - 47.770 -39.699 - 1. 069 1, .00 38.45 NATOM 2701 N ILE B 163-47.770 -39.699-1. 069 1, .00 38.45 N
ATOM 2702 CA ILE B 163 -46.569 -40.263 -1. 653 1, .00 36.28 GATOM 2702 CA ILE B 163 -46.569 -40.263 -1. 653 1, .00 36.28 G
ATOM 2703 CB ILE B 163 -46.820 -41.719 - 2. 085 1, .00 34.85 CATOM 2703 CB ILE B 163 -46.820 -41.719-2. 085 1, .00 34.85 C
ATOM 2704 CG2 ILE B 163 -45.559 -42.321 -2. 676 1, .00 35.89 CATOM 2704 CG2 ILE B 163 -45.559 -42.321 -2. 676 1, .00 35.89 C
ATOM 2705 C61 ILE B 163 - 47.255 - 42.539 -0. 872 1 .00 33.45 CATOM 2705 C61 ILE B 163-47.255-42.539 -0. 872 1 .00 33.45 C
ATOM 2706 CD1 ILE B 163 -47.781 -43.912 -1. 213 1 .00 32.92 CATOM 2706 CD1 ILE B 163 -47.781 -43.912 -1. 213 1 .00 32.92 C
ATOM 2707 C ILE B 163 -46.172 - 39.433 -2. 860 1 ,00 34.87 CATOM 2707 C ILE B 163 -46.172-39.433 -2. 860 1, 00 34.87 C
ATOM 2708 0 ILE B 163 - 47.022 -38.845 -3. 519 1 • 00 36.60 0ATOM 2708 0 ILE B 163-47.022 -38.845 -3. 519 1 • 00 36.60 0
ATOM 2709 N LYS B 164 -44.876 -39.366 - 3. 132 1 ■ 00 33.26 NATOM 2709 N LYS B 164 -44.876 -39.366-3. 132 1 ∎ 00 33.26 N
ATOM 2710 CA LYS B 164 -44.384 -38.746 -4. 357 1 .00 31.30 CATOM 2710 CA LYS B 164 -44.384 -38.746 -4. 357 1 .00 31.30 C
ATOM 2711 CB LYS B 164 -43.858一 37.335 一 4. ,093 1 .00 29.58 C ATOM 2712 CG LYS B 164 - 44.901 -36.380 - 3.549 1.00 28.48 CATOM 2711 CB LYS B 164 -43.858 One 37.335 One 4., 093 1 .00 29.58 C ATOM 2712 CG LYS B 164-44.901 -36.380-3.549 1.00 28.48 C
ATOM 2713 CD LYS B 164 - 44.411 -34.954 -3.529 1. 00 28.66 CATOM 2713 CD LYS B 164-44.411 -34.954 -3.529 1. 00 28.66 C
ATOM 2714 CE LYS B 164 - 45.536 -34.006 -3.137 1. 00 30.54 CATOM 2714 CE LYS B 164-45.536 -34.006 -3.137 1. 00 30.54 C
ATOM 2715 NZ LYS B 164 - 45.215 -32.589 -3.474 1. 00 31. 79 NATOM 2715 NZ LYS B 164-45.215 -32.589 -3.474 1. 00 31. 79 N
ATOM 2716 C LYS B 164 -43.270 - 39.597 -4.930 1. 00 32.20 CATOM 2716 C LYS B 164 -43.270-39.597 -4.930 1. 00 32.20 C
ATOM 2717 0 LYS B 164 -42.525 -40.251 -4.192 1. 00 32.23 0ATOM 2717 0 LYS B 164 -42.525 -40.251 -4.192 1.00 32.23 0
ATOM 2718 N VAL B 165 -43.165 - 39.594 -6.251 1. 00 30.92 NATOM 2718 N VAL B 165 -43.165-39.594 -6.251 1. 00 30.92 N
ATOM 2719 CA VAL B 165 -42.164 -40.390 - 6.924 1. 00 29.05 CATOM 2719 CA VAL B 165 -42.164 -40.390-6.924 1. 00 29.05 C
ATOM 2720 CB VAL B 165 - 42.810一 41. 334 -7.960 1. 00 30.43 CATOM 2720 CB VAL B 165-42.810 1 41. 334 -7.960 1. 00 30.43 C
ATOM 2721 CG1 VAL B 165 -41. 748 -42.240 -8.577 1. 00 29. 18 CATOM 2721 CG1 VAL B 165 -41. 748 -42.240 -8.577 1. 00 29. 18 C
ATOM 2722 C62 VAL B 165 - 43. 899 - 42.161 - 7.300 1. 00 29. 15 CATOM 2722 C62 VAL B 165-43. 899-42.161-7.300 1. 00 29. 15 C
ATOM 2723 G VAL B 165 - 41. 213 -39. 454 -7.638 1. 00 28. 76 CATOM 2723 G VAL B 165-41. 213 -39. 454 -7.638 1. 00 28. 76 C
ATOM 2724 0 VAL B 165 -41. 642 -38. 500 -8.284 1. 00 27. 62 _ 0ATOM 2724 0 VAL B 165 -41. 642 -38. 500 -8.284 1. 00 27. 62 _ 0
ATOM 2725 N LEU B 166 - 39. 921 -39. 730 -7.513 1. 00 28. 19 NATOM 2725 N LEU B 166-39. 921 -39. 730 -7.513 1. 00 28. 19 N
ATOM 2726 CA LEU B 166 -38. 905 -39. 017 -8.273 1. 00 29. 03 CATOM 2726 CA LEU B 166 -38. 905 -39. 017 -8.273 1. 00 29. 03 C
ATOM 2727 CB LEU B 166 -37. 930 -38. 309 -7.325 1. 00 29. 45 CATOM 2727 CB LEU B 166 -37. 930 -38. 309 -7.325 1. 00 29. 45 C
ATOM 2728 CG LEU B 166 - 38. 551 -37. 494 -6.181 1. 00 30. 13 CATOM 2728 CG LEU B 166-38. 551 -37. 494 -6.181 1. 00 30. 13 C
ATOM 2729 CD1 LEU B 166 - 37. 464 - 37. 066 - 5.197 1. 00 30. 83 CATOM 2729 CD1 LEU B 166-37. 464-37. 066-5.197 1. 00 30. 83 C
ATOM 2730 CD2 LEU B 166 - 39. 270 -36. 279 -6.743 1. 00 30. 20 CATOM 2730 CD2 LEU B 166-39. 270 -36. 279 -6.743 1. 00 30. 20 C
ATOM 2731 C LEU B 166 -38. 154 -40. 037 -9.118 1. 00 29. 53 CATOM 2731 C LEU B 166 -38. 154 -40. 037 -9.118 1. 00 29. 53 C
ATOM 2732 0 LEU B 166 -37. 676 - 41. 050 -8.606 1. 00 27. 37 0ATOM 2732 0 LEU B 166 -37. 676-41. 050 -8.606 1. 00 27. 37 0
ATOM 2733 N VAL B 167 -38. 062 -39. 770 -10.417 1. ,00 28. 70 NATOM 2733 N VAL B 167 -38. 062 -39. 770 -10.417 1., 00 28. 70 N
ATOM 2734 CA VAL B 167 - 37. 333 - 40. 647 -11'.322 1. ,00 26. 19 CATOM 2734 CA VAL B 167-37. 333-40. 647 -11'.322 1., 00 26. 19 C
ATOM 2735 CB VAL B 167 - 38. 306 -41. 546 -12.118 1. ,00 25. 12 CATOM 2735 CB VAL B 167-38. 306 -41. 546 -12.118 1., 00 25. 12 C
ATOM 2736 CG1 VAL B 167 -39. 303 -42. 181 -11. 61 1. .00 25. 33 CATOM 2736 CG1 VAL B 167 -39. 303 -42. 181 -11. 61 1. .00 25. 33 C
ATOM 2737 CG2 VAL B 167 - 39· 021 - 40. 748 -13.187 1. ,00 24. 18 CATOM 2737 CG2 VAL B 167-39 ・ 021-40. 748 -13.187 1., 00 24. 18 C
ATOM 2738 C VAL B 167 - 36. 488 - 39. 818 -12.284 1. .00 26. 84 CATOM 2738 C VAL B 167-36. 488-39. 818 -12.284 1. .00 26. 84 C
ATOM 2739 0 VAL B 167 - 36. 763 -38. 640 -12.500 1. .00 27. 48 0ATOM 2739 0 VAL B 167-36. 763 -38. 640 -12.500 1. .00 27. 48 0
ATOM 2740 N LEU B 168 -35. 450 -40. 428 - 12.846 1. .00 27. 16 NATOM 2740 N LEU B 168 -35. 450 -40. 428-12.846 1. .00 27. 16 N
ATOM 2741 CA LEU B 168 -34. 560 -39. 722 - 13.759 1. .00 29. 41 CATOM 2741 CA LEU B 168 -34. 560 -39. 722-13.759 1. .00 29. 41 C
ATOM 2742 CB LEU B 168 -33. 241 -40. 485 -13.906 1, .00. 29. 83 CATOM 2742 CB LEU B 168 -33. 241 -40. 485 -13.906 1, .00. 29. 83 C
ATOM 2743 CG LEU B 168 - 32. 044 - 39. 981 -13.099 1. .00 32. 06 CATOM 2743 CG LEU B 168-32. 044-39. 981 -13.099 1. .00 32. 06 C
ATOM 2744 CD1 LEU B 168 - 32. 513 -39. 212 -11.874 1, .00 33. 68 CATOM 2744 CD1 LEU B 168-32. 513 -39. 212 -11.874 1, .00 33. 68 C
ATOM 2745 GD2 LEU B 168 -31. 172 -41. 157 -12.711 1. .00 31. 30 CATOM 2745 GD2 LEU B 168 -31. 172 -41. 157 -12.711 1. .00 31. 30 C
ATOM 2746 C LEU B 168 -35. 221 - 39. 586 - 15.120 1, .00 29. 77 CATOM 2746 C LEU B 168 -35. 221-39. 586-15.120 1, .00 29. 77 C
ATOM 2747 0 LEU B 168 -35. 305 -38. 494 -15.680 1, .00 32. 13 0 ATOM 2748 N VAL B 169 - 35.686 -40.712 -15.644 1.00 28.63 ΝATOM 2747 0 LEU B 168 -35. 305 -38. 494 -15.680 1, .00 32. 13 0 ATOM 2748 N VAL B 169-35.686 -40.712 -15.644 1.00 28.63 Ν
ATOM 2749 CA VAL B 169 -36.284 —40.769 -16.970 1. 00 28.63 CATOM 2749 CA VAL B 169 -36.284 —40.769 -16.970 1. 00 28.63 C
ATOM 2750 CB VAL B 169 -35.334 -41.462 -17. 980 1. 00 28.15 CATOM 2750 CB VAL B 169 -35.334 -41.462 -17. 980 1. 00 28.15 C
ATOM 2751 CG1 VAL B 169 - 36.045 -41.699 - 19. 276 1. 00 30.68 CATOM 2751 CG1 VAL B 169-36.045 -41.699-19. 276 1. 00 30.68 C
ATOM 2752 CG2 VAL B 169 -34.114 -40.598 -18. 226 1. 00 27.79 CATOM 2752 CG2 VAL B 169 -34.114 -40.598 -18. 226 1. 00 27.79 C
ATOM 2753 C VAL B 169 -37.580 -41.560 -16. 889 1, 00 28.73 CATOM 2753 C VAL B 169 -37.580 -41.560 -16. 889 1, 00 28.73 C
ATOM 2754 0 VAL B 169 -37.634 -42.608 - 16. 244 1. 00 29.20 0ATOM 2754 0 VAL B 169 -37.634 -42.608-16. 244 1. 00 29.20 0
ATOM 2755 N ALA B 170 -38.626 -17. 536 1. 00 28.82 ΝATOM 2755 N ALA B 170 -38.626 -17. 536 1. 00 28.82 Ν
ATOM 2756 CA ALA B 170 -39.923 - 41.726 -17. 486 1. 00 30.86 CATOM 2756 CA ALA B 170 -39.923-41.726 -17. 486 1. 00 30.86 C
ATOM 2757 CB ALA B 170 - 40.894 - 40.920 -16. 629 1. 00 28.23 CATOM 2757 CB ALA B 170-40.894-40.920 -16. 629 1. 00 28.23 C
ATOM 2758 C ALA B 170 -40.494 1 ATOM 2758 C ALA B 170 -40.494 1
ATOM 2759 ,0 ALA B 170 - 40.425 ATOM 2759, 0 ALA B 170-40.425
O C O C
ATOM 2760 N ALA B 171 -41.047
Figure imgf000106_0001
O ATOM 2760 N ALA B 171 -41.047
Figure imgf000106_0001
O
ATOM 2761 CA ALA B 171 -41.806 -43.357 -20. 349 1. 00 32.33 C ATOM 2761 CA ALA B 171 -41.806 -43.357 -20. 349 1. 00 32.33 C
ATOM 2762 CB ALA B 171 -41 · 699 -44.823 -20. 721 1. 00 32.69 CATOM 2762 CB ALA B 171 -41 699 -44.823 -20. 721 1. 00 32.69 C
ATOM 2763 C ALA B 171 -43.273 - 42.973 -20. 139 1. 00 33.39 CATOM 2763 C ALA B 171 -43.273-42.973 -20. 139 1. 00 33.39 C
ATOM 2764 0 ALA B 171 -43.805 - 43· 085 -19. 037 1. 00 33.16 0ATOM 2764 0 ALA B 171 -43.805-43 085 -19. 037 1. 00 33.16 0
ATOM 2765 N PRO B 172 - 43.940 -42.500 -21. 198 1. 00 34.16 ΝATOM 2765 N PRO B 172-43.940 -42.500 -21. 198 1. 00 34.16 Ν
. 0 0  . 0 0
ATOM 2766 CD PRO B 172 - 43.363 - 42.054 -22. 477 1 00 32.81 C ATOM 2766 CD PRO B 172-43.363-42.054 -22. 477 1 00 32.81 C
ATOM 2767 CA PRO B 172 -45.382 -42.243 -21. 123 1. 00 35.39 CATOM 2767 CA PRO B 172 -45.382 -42.243 -21. 123 1. 00 35.39 C
ATOM 2768 CB PRO B 172 - 45.729 -41.769 -22. 532 1. 00 35.98 CATOM 2768 CB PRO B 172-45.729 -41.769 -22. 532 1. 00 35.98 C
ATOM 2769 CG PRO B 172 - 44.449 - 23. 052 1. ,00 33.39 GATOM 2769 CG PRO B 172-44.449-23. 052 1., 00 33.39 G
ATOM 2770 C PRO B 172 -46.171 - 43.492 -20.721 1. 00 38.36 CATOM 2770 C PRO B 172 -46.171-43.492 -20.721 1. 00 38.36 C
ATOM 2771 0 PRO B 172 -47.112 -43.419 -19. 924 1. ,00 38.64 0ATOM 2771 0 PRO B 172 -47.112 -43.419 -19. 924 1., 00 38.64 0
ATOM 2772 N GLU B 173 - 45.777 -44.638 - 21. 273 1. .00 39.91 ΝATOM 2772 N GLU B 173-45.777 -44.638-21. 273 1. .00 39.91 Ν
ATOM 2773 CA 6LU B 173 -46.413 -45.908 -20. 950 1. .00 41.28 CATOM 2773 CA 6LU B 173 -46.413 -45.908 -20. 950 1. .00 41.28 C
ATOM 2774 CB GLU B 173 - 45.695 -47.061 - 21. 664 1. .00 42.98 CATOM 2774 CB GLU B 173-45.695 -47.061-21. 664 1. .00 42.98 C
ATOM 2775 CG GLU B 173 -45.679 -46.960 -23. 180 1. .00 46.29 CATOM 2775 CG GLU B 173 -45.679 -46.960 -23. 180 1. .00 46.29 C
ATOM 2776 CD GLU B 173 -44.603 -46.018 -23. 691 1. .00 49.89 CATOM 2776 CD GLU B 173 -44.603 -46.018 -23. 691 1. .00 49.89 C
ATOM 2777 0E1 GLU B 173 - 43.604 -46.511 -24. 254 1, .00 0ATOM 2777 0E1 GLU B 173-43.604 -46.511 -24. 254 1, .00 0
ATOM 2778 0E2 GLU B 173 -44.754 -44.785 -23. 534 1, .00 50.55 0ATOM 2778 0E2 GLU B 173 -44.754 -44.785 -23. 534 1, .00 50.55 0
ATOM 2779 C GLU B 173 -46.372 -46.142 -19. 440 1, .00 41.30 CATOM 2779 C GLU B 173 -46.372 -46.142 -19. 440 1, .00 41.30 C
ATOM 2780 0 GLU B 173 -47.344 -46.603 -18. 838 1, .00 41.88 0ATOM 2780 0 GLU B 173 -47.344 -46.603 -18. 838 1, .00 41.88 0
ATOM 2781 N GLY B 174 -45.237 -45.825 -18. 833 1, .00 39.05 ΝATOM 2781 N GLY B 174 -45.237 -45.825 -18. 833 1, .00 39.05 Ν
ATOM 2782 CA 6LY B 174 -45.130 - 45.953 -17. ,396 1 .00 39.82 CATOM 2782 CA 6LY B 174 -45.130-45.953 -17., 396 1 .00 39.82 C
ATOM 2783 C GLY B 174 一 45.977 -44.907 -16. ,701 1 .00 38.79 C P T/JP2007/071755 ATOM 2783 C GLY B 174 1 45.977 -44.907 -16., 701 1 .00 38.79 C PT / JP2007 / 071755
ATOM 2784 0 6LY B 174 -46.686 -45.200 -15.739 1. 00 39.70 0ATOM 2784 0 6LY B 174 -46.686 -45.200 -15.739 1. 00 39.70 0
ATOM 2785 N ILE B 175 -45.915 -43.679 -17.195 1. 00 38.20 NATOM 2785 N ILE B 175 -45.915 -43.679 -17.195 1. 00 38.20 N
ATOM 2786 CA ILE B 175 -46.642 -42.592 -16.566 1. 00 38.58 CATOM 2786 CA ILE B 175 -46.642 -42.592 -16.566 1. 00 38.58 C
ATOM 2787 CB ILE B 175 -46.322 -41.245 -17.238 1. 00 37.68 CATOM 2787 CB ILE B 175 -46.322 -41.245 -17.238 1. 00 37.68 C
ATOM 2788 CG2 ILE B 175 -47.298 -40.173 -16.754 1. 00 36.39 CATOM 2788 CG2 ILE B 175 -47.298 -40.173 -16.754 1. 00 36.39 C
ATOM 2789 GG1 ILE B 175 -44.866 -40.860 -16.935 1. 00 36.01 CATOM 2789 GG1 ILE B 175 -44.866 -40.860 -16.935 1.00 36.01 C
ATOM 2790 CD1 ILE B 175 -44.383 - 39.602 -17.640 1. 00 32.89 CATOM 2790 CD1 ILE B 175 -44.383-39.602 -17.640 1.00 32.89 C
ATOM 2791 G ILE B 175 -48.144 - 42.843 -16.598 1. 00 38.94 CATOM 2791 G ILE B 175 -48.144-42.843 -16.598 1. 00 38.94 C
ATOM 2792 0 ILE B 175 - 48.819 -42.702 -15.577 1. 00 41.09 0ATOM 2792 0 ILE B 175-48.819 -42.702 -15.577 1.00 41.09 0
ATOM 2793 N ALA B 176 -48.660 -43.233 -17.760 1. 00 38.25 NATOM 2793 N ALA B 176 -48.660 -43.233 -17.760 1. 00 38.25 N
ATOM 2794 CA ALA B 176 -50.077 - 43.556 -17.894 1. 00 36.65 CATOM 2794 CA ALA B 176 -50.077-43.556 -17.894 1. 00 36.65 C
ATOM 2795 , CB ALA B 176 -50.366 -44.052 -19.300 1. 00 35.11 CATOM 2795, CB ALA B 176 -50.366 -44.052 -19.300 1.00 35.11 C
ATOM 2796 C ALA B 176 - 50.492 -44.612 -16.867 1. 00 36.86 CATOM 2796 C ALA B 176-50.492 -44.612 -16.867 1.00 36.86 C
ATOM 2797 0 ALA B 176 - 51.469 - 44.434 - 16.140 1. 00 37.79 0ATOM 2797 0 ALA B 176-51.469-44.434-16.140 1. 00 37.79 0
ATOM 2798 N ALA B 177 -49.742 -45.703 -16.792 1. 00 35.29 NATOM 2798 N ALA B 177 -49.742 -45.703 -16.792 1. 00 35.29 N
ATOM 2799 CA ALA B 177 - 50.060 -46.760 -15.848 1. 00 34.80 CATOM 2799 CA ALA B 177-50.060 -46.760 -15.848 1. 00 34.80 C
ATOM 2800 CB ALA B 177 - 49.071 -47.881 -15.996 1. 00 33.63 CATOM 2800 CB ALA B 177-49.071 -47.881 -15.996 1.00 33.63 C
ATOM 2801 C ALA B 177 -50.080 -46.255 -14.401 1. 00 37.41 CATOM 2801 C ALA B 177 -50.080 -46.255 -14.401 1.00 37.41 C
ATOM 2802 0 ALA B 177 -50.942 -46.651 -13.615 1. 00 39.56 0ATOM 2802 0 ALA B 177 -50.942 -46.651 -13.615 1. 00 39.56 0
ATOM 2803 N LEU B 178 - 49.140 -45.380 -14.051 1. 00 37.13 NATOM 2803 N LEU B 178-49.140 -45.380 -14.051 1. 00 37.13 N
ATOM 2804 CA LEU B 178 -49.090 -44.796 -12.709 1. 00 36.65 CATOM 2804 CA LEU B 178 -49.090 -44.796 -12.709 1.00 36.65 C
ATOM 2805 CB LEU B 178 -47.857 - 43.891 -12.567 1. ,00 35.80 CATOM 2805 CB LEU B 178 -47.857-43.891 -12.567 1., 00 35.80 C
ATOM 2806 CG LEU B 178 -47.222 -43.671 - 11.185 1. ,00 34.97 CATOM 2806 CG LEU B 178 -47.222 -43.671-11.185 1., 00 34.97 C
ATOM 2807 CD1 LEU B 178 - 46.273 - 42.487 -11.273 1. .00 35.07 CATOM 2807 CD1 LEU B 178-46.273-42.487 -11.273 1. .00 35.07 C
ATOM 2808 CD2 LEU B 178 -48.272 -43.414 -10.122 1. .00 34.37 CATOM 2808 CD2 LEU B 178 -48.272 -43.414 -10.122 1. .00 34.37 C
ATOM 2809 C LEU B 178 -50.344 -43.964 -12.444 1. .00 37.21 CATOM 2809 C LEU B 178 -50.344 -43.964 -12.444 1. .00 37.21 C
ATOM 2810 0 LEU B 178 - 50.940 -44.038 -11.368 1. .00 35.69 0ATOM 2810 0 LEU B 178-50.940 -44.038 -11.368 1. .00 35.69 0
ATOM 2811 N GLU B 179 -50.737 -43.159 -13.426 1. .00 39.38 NATOM 2811 N GLU B 179 -50.737 -43.159 -13.426 1. .00 39.38 N
ATOM 2812 CA GLU B 179 -51■ 868 -42.254 -13.249 1. .00 42.33 CATOM 2812 CA GLU B 179 -51 868 -42.254 -13.249 1. .00 42.33 C
ATOM 2813 CB 6LU B 179 -52.012 -41.330 -14.462 1. .00 42.68 CATOM 2813 CB 6LU B 179 -52.012 -41.330 -14.462 1. .00 42.68 C
ATOM 2814 CG GLU B 179 -50.778 - 40.493 -14.762 1, .00.45.68 CATOM 2814 CG GLU B 179 -50.778-40.493 -14.762 1, .00.45.68 C
ATOM 2815 CD GLU B 179 -51.100 -39.229 -15.548 1, .00 47.43 CATOM 2815 CD GLU B 179 -51.100 -39.229 -15.548 1, .00 47.43 C
ATOM 2816 0E1 GLU B 179 -50.483 -39.005 -16.612 1, .00 48.81 0ATOM 2816 0E1 GLU B 179 -50.483 -39.005 -16.612 1, .00 48.81 0
ATOM 2817 0E2 GLU B 179 -51.969 - 38.453 - 15.099 1, .00 49.40 0ATOM 2817 0E2 GLU B 179 -51.969-38.453-15.099 1, .00 49.40 0
ATOM 2818 C GLU B 179 -53.159 -43.041 -13.050 1, • 00 43.62 CATOM 2818 C GLU B 179 -53.159 -43.041 -13.050 1, • 00 43.62 C
ATOM 2819 0 GLU B 179 -54.069 -42.593 -12.349 1 • 00 44.86 0 ATOM 2820 N LYS B 180 -53.235 - 44.219 -13.661 1.00 43.22 NATOM 2819 0 GLU B 179 -54.069 -42.593 -12.349 1 • 00 44.86 0 ATOM 2820 N LYS B 180 -53.235-44.219 -13.661 1.00 43.22 N
ATOM 2821 CA LYS B 180 - 54.445 -45.023 - 13.600 1. 00 44.03 CATOM 2821 CA LYS B 180-54.445 -45.023-13.600 1. 00 44.03 C
ATOM 2822 CB LYS B 180 -54.470 -46.011 -14.770 1. 00 46.05 CATOM 2822 CB LYS B 180 -54.470 -46.011 -14.770 1.00 46.05 C
ATOM 2823 CG LYS B 180 -55.834 - 46.604 -15.069 1. 00 47.64 CATOM 2823 CG LYS B 180 -55.834-46.604 -15.069 1.00 47.64 C
ATOM 2824 CD LYS B 180 - 55.747 -47.584 - 16.227 1. 00 50.24 CATOM 2824 CD LYS B 180-55.747 -47.584-16.227 1. 00 50.24 C
ATOM 2825 CE LYS B 180 -57.052 -48.333 -16.429 1. 00 51.53 CATOM 2825 CE LYS B 180 -57.052 -48.333 -16.429 1. 00 51.53 C
ATOM 2826 NZ LYS B 180 -56. 830 -49.614 -17.159 1. 00 52.98 NATOM 2826 NZ LYS B 180 -56. 830 -49.614 -17.159 1. 00 52.98 N
ATOM 2827 C LYS B 180 - 54. 525 -45.774 -12.273 1. 00 43.08 CATOM 2827 C LYS B 180-54. 525 -45.774 -12.273 1. 00 43.08 C
ATOM 2828 0 LYS B 180 -55. 560 - 45.760 -11.607 1. 00 42.38 0ATOM 2828 0 LYS B 180 -55. 560-45.760 -11.607 1. 00 42.38 0
ATOM 2829 N ALA B 181 -53. 424 -46.413 -11.888 1. 00 41.56 NATOM 2829 N ALA B 181 -53. 424 -46.413 -11.888 1.00 41.56 N
ATOM 2830 CA ALA B 181 -53. 367 -47. 162 -10.639 1. 00 39.82 CATOM 2830 CA ALA B 181 -53. 367 -47. 162 -10.639 1. 00 39.82 C
ATOM 2831 ■ CB ALA B 181 - 52. 091 -47. 990 -10.579 1. 00 38.67 CATOM 2831 ■ CB ALA B 181-52. 091 -47. 990 -10.579 1. 00 38.67 C
ATOM 2832 C ALA B 181 -53. 446 -46. 259 - 9.421 1. 00 39.80 GATOM 2832 C ALA B 181 -53. 446 -46. 259-9.421 1. 00 39.80 G
ATOM 2833 0 ALA B 181 -54. 051 -46. 631 -8.419 1. 00 39.67 0ATOM 2833 0 ALA B 181 -54. 051 -46. 631 -8.419 1. 00 39.67 0
ATOM 2834 N HIS B 182 一 52. 831 -45. 080 - 9.508 1. 00 40.98 NATOM 2834 N HIS B 182 1 52. 831 -45. 080-9.508 1. 00 40.98 N
ATOM 2835 CA HIS B 182 -52. 705 -44. 173 -8.363 1. 00 41.47 CATOM 2835 CA HIS B 182 -52. 705 -44. 173 -8.363 1. 00 41.47 C
ATOM 2836 CB HIS B 182 - 51. 372 -44. 408 - 7.654 1. 00 38.25 CATOM 2836 CB HIS B 182-51. 372 -44. 408-7.654 1. 00 38.25 C
ATOM 2837 CG HIS B 182 - 51. 203 -45. 796 - 7.123 1. 00 36.94 CATOM 2837 CG HIS B 182-51. 203 -45. 796-7.123 1. 00 36.94 C
ATOM 2838 CD2 HIS B 182 - 50. 437 -46. 827 - 7.550 1. 00. 37.24 CATOM 2838 CD2 HIS B 182-50. 437 -46. 827-7.550 1. 00. 37.24 C
ATOM 2839 ND1 HIS B 182 - 51. 869 -46. 251 - 6.006 1. 00 36.99 NATOM 2839 ND1 HIS B 182-51. 869 -46. 251-6.006 1. 00 36.99 N
ATOM 2840 CE1 HIS B 182 -51. 520一 47. 503 -5.767 1. 00 35.52 CATOM 2840 CE1 HIS B 182 -51. 520 1 47. 503 -5.767 1. 00 35.52 C
ATOM 2841 NE2 HIS B 182 -50. 652 -47. 876 -6.689 1. .00 35.53 NATOM 2841 NE2 HIS B 182 -50. 652 -47. 876 -6.689 1. .00 35.53 N
ATOM 2842 C HIS B 182 - 52. 783 - 42. 701 -8.771 1. 00 43.53 CATOM 2842 C HIS B 182-52. 783-42. 701 -8.771 1. 00 43.53 C
ATOM 2843 0 HIS B 182 - 51. 767 -42. 018 -8.858 1. ,00 45.23 0ATOM 2843 0 HIS B 182-51. 767 -42. 018 -8.858 1., 00 45.23 0
ATOM 2844 N PRO B 183 -53. 995 -42. 188 -9.013 1. ,00 44.97 NATOM 2844 N PRO B 183 -53. 995 -42. 188 -9.013 1., 00 44.97 N
ATOM 2845 CD PRO B 183 -55. 298 - 42. 835 -8.785 1. .00 46.61 CATOM 2845 CD PRO B 183 -55. 298-42. 835 -8.785 1. .00 46.61 C
ATOM 2846 CA PRO B 183 -54. 140 -40. 831 -9.549 1. ,00 46.29 CATOM 2846 CA PRO B 183 -54. 140 -40. 831 -9.549 1., 00 46.29 C
ATOM 2847 CB PRO B 183 - 55. 632 -40. 727 - 9.863 1. .00 45.16 CATOM 2847 CB PRO B 183-55. 632 -40. 727-9.863 1. .00 45.16 C
ATOM 2848 CG PRO B 183 -56. 276 -41. 704 - 8.946 1. ,00 45.11 CATOM 2848 CG PRO B 183 -56. 276 -41. 704-8.946 1., 00 45.11 C
ATOM 2849 G PRO B 183 - 53· 672 - 39. 744 - 8.584 1. .00 47.34 CATOM 2849 G PRO B 183-53 672-39. 744-8.584 1. .00 47.34 C
ATOM 2850 0 PRO B 183 -53. 491 -38. 589 -8.974 1. .00 47.63 0ATOM 2850 0 PRO B 183 -53. 491 -38. 589 -8.974 1. .00 47.63 0
ATOM 2851 N ASP B 184 -53. 474 -40. 124 - 7.326 1. .00 48.28 NATOM 2851 N ASP B 184 -53. 474 -40. 124-7.326 1. .00 48.28 N
ATOM 2852 CA ASP B 184 - 53. 118 - 39. 170 -6.275 1. ,00 47.20 CATOM 2852 CA ASP B 184-53. 118-39. 170 -6.275 1., 00 47.20 C
ATOM 2853 CB ASP B 184 - 53. 736 -39. 610 -4.946 1, .00 48.38 CATOM 2853 CB ASP B 184-53. 736 -39. 610 -4.946 1, .00 48.38 C
ATOM 2854 CG ASP B 184 -53. 437 -41. 055 -4.619 1. .00 49.85 CATOM 2854 CG ASP B 184 -53. 437 -41. 055 -4.619 1. .00 49.85 C
ATOM 2855 0D1 ASP B 184 -53. 188 —41. 361 —3.432 1, .00 52.74 0 80ΐ ATOM 2855 0D1 ASP B 184 -53. 188 --41. 361 --3.432 1, .00 52.74 0 80ΐ
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SS.T.0/.00Zdf/X3d ATOM 2892 OH TYR B 188 -44.423 -31.367 -7.200 1.00 29.03 0SS.T.0 / .00Zdf / X3d ATOM 2892 OH TYR B 188 -44.423 -31.367 -7.200 1.00 29.03 0
ATOM 2893 C TYR B 188 -40.117 -36.477 -11.428 1. 00 27.69 CATOM 2893 C TYR B 188 -40.117 -36.477 -11.428 1. 00 27.69 C
ATOM 2894 0 TYR B 188 -39.460 -37.329 -10.843 1. 00 27.63 0ATOM 2894 0 TYR B 188 -39.460 -37.329 -10.843 1.00 27.63 0
ATOM 2895 N THR B 189 -39.902 -36.149 -12.692 1. 00 28.03 NATOM 2895 N THR B 189 -39.902 -36.149 -12.692 1. 00 28.03 N
ATOM 2896 CA THR B 189 -38.892 -36.823 -13.491 1. 00 27.93 CATOM 2896 CA THR B 189 -38.892 -36.823 -13.491 1. 00 27.93 C
ATOM 2897 CB THR B 189 -39.544 -37.668 -14.596 1. 00 26.85 CATOM 2897 CB THR B 189 -39.544 -37.668 -14.596 1.00 26.85 C
ATOM 2898 0G1 THR B 189 - 38.525 - 38.288 -15.387 1. 00 27.85 0ATOM 2898 0G1 THR B 189-38.525-38.288 -15.387 1. 00 27.85 0
ATOM 2899 CG2 THR B 189 -40.420 -36.794 -15.483 1. 00 26.08 CATOM 2899 CG2 THR B 189 -40.420 -36.794 -15.483 1.00 26.08 C
ATOM 2900 C THR B 189 -37.960 -35.812 -14.141 1. 00 27.66 CATOM 2900 C THR B 189 -37.960 -35.812 -14.141 1.00 27.66 C
ATOM 2901 0 THR B 189 -38. 402 -34.777 —14.618 1. 00 28.88 0ATOM 2901 0 THR B 189 -38. 402 -34.777 --14.618 1. 00 28.88 0
ATOM 2902 N ALA B 190 -36. 666 -36.108 -14.155 1. 00 29.43 NATOM 2902 N ALA B 190 -36.666 -36.108 -14.155 1.00 29.43 N
ATOM 2903 CA ALA B 190 一 35. 724 - 35.265 - 14.875 1. 00 29.22 .· CATOM 2903 CA ALA B 190 35.724-35.265-14.875 1. 00 29.22.
ATOM 2904 CB ALA B 190 -34. 305 -35.779 -14.673 1. 00 30.42 CATOM 2904 CB ALA B 190 -34. 305 -35.779 -14.673 1. 00 30.42 C
ATOM 2905 C ALA B 190 - 36. 083 - 35.242 -16.363 1. 00 29.26 CATOM 2905 C ALA B 190-36. 083-35.242 -16.363 1. 00 29.26 C
ATOM 2906 0 ALA B 190 -35. 708 - 34.323 -17.084n i 1. 00 29.23 0ATOM 2906 0 ALA B 190 -35. 708-34.323 -17.084n i 1. 00 29.23 0
ATOM 2907 N SER B 191 - 36. 821 -36.246 -16.825 1. ,00 29.83 NATOM 2907 N SER B 191-36. 821 -36.246 -16.825 1., 00 29.83 N
ATOM 2908 CA SER B 191 -37. 277 - 36.239 -18.212 1. 00 31.43 CATOM 2908 CA SER B 191 -37. 277-36.239 -18.212 1. 00 31.43 C
ATOM 2909 CB SER B 191 -36. 092 -36.518 -19.148 1. ,00 30.89 CATOM 2909 CB SER B 191 -36. 092 -36.518 -19.148 1., 00 30.89 C
ATOM 2910 OG SER B 191 -36. 500 -36.566 -20.505 1. 00 33.55 0ATOM 2910 OG SER B 191 -36. 500 -36.566 -20.505 1. 00 33.55 0
ATOM 2911 C SER B 191 -38. 433 -37.204 -18.531 1. ,00 31.23 cATOM 2911 C SER B 191 -38. 433 -37.204 -18.531 1., 00 31.23 c
ATOM 2912 0 SER B 191 -38. 591 -38.249 -17.907 1. ,00 27.23 0ATOM 2912 0 SER B 191 -38. 591 -38.249 -17.907 1., 00 27.23 0
ATOM 2913 N ILE B 192 -39. 239 - 36.823 -19.517 1. ,00 33.28 NATOM 2913 N ILE B 192 -39. 239-36.823 -19.517 1., 00 33.28 N
ATOM '2914 CA ILE B 192 -40. 227 -37.710 -20.120 1. .00 33.75 CATOM '2914 CA ILE B 192 -40. 227 -37.710 -20.120 1..00 33.75 C
ATOM 2915 CB ILE B 192 - 41. 589 -36.991 -20.266 1. .00 33.93 CATOM 2915 CB ILE B 192-41. 589 -36.991 -20.266 1. .00 33.93 C
ATOM 2916 CG2 ILE B 192 -42. 543 -37.832 1. .00 33.72 CATOM 2916 CG2 ILE B 192 -42. 543 -37.832 1. .00 33.72 C
ATOM 2917 CG1 ILE B 192 -42. 173 - 36.691 -18.882 1. .00 32.41 CATOM 2917 CG1 ILE B 192 -42. 173-36.691 -18.882 1. .00 32.41 C
ATOM 2918 CD1 ILE B 192 -43. 555 -36.064 - 18.923 1. .00 30.23 CATOM 2918 CD1 ILE B 192 -43. 555 -36.064-18.923 1. .00 30.23 C
ATOM 2919 C ILE B 192 -39. 723 -38.100 -21 · 508 1. .00 34.32 CATOM 2919 C ILE B 192 -39. 723 -38.100 -21 508 1. .00 34.32 C
ATOM 2920 0 ILE B 192 - 39. 773 -37.296 -22.436 1, .00 34.19 0ATOM 2920 0 ILE B 192-39. 773 -37.296 -22.436 1, .00 34.19 0
ATOM 2921 N ASP B 193 -39. 236 -39.327 1, .00 34.95 NATOM 2921 N ASP B 193 -39. 236 -39.327 1, .00 34.95 N
ATOM 2922 CA ASP B 193 - 38. 674 -39.761 -22.933 1, .00 36.17 GATOM 2922 CA ASP B 193-38. 674 -39.761 -22.933 1, .00 36.17 G
ATOM 2923 CB ASP B 193 -37. 734 -40.950 -22.719 1, .00 35.94 CATOM 2923 CB ASP B 193 -37. 734 -40.950 -22.719 1, .00 35.94 C
ATOM 2924 C6 ASP B 193 - 36. 347 -40.526 -22.260 1, .00 36.01 CATOM 2924 C6 ASP B 193-36. 347 -40.526 -22.260 1, .00 36.01 C
ATOM 2925 0D1 ASP B 193 - 36. 162 -39.351 -21.877 1 .00 35.96 0ATOM 2925 0D1 ASP B 193-36. 162 -39.351 -21.877 1 .00 35.96 0
ATOM 2926 0D2 ASP B 193 -35. 435 -41.373 -22.286 1, .00 37.34 0ATOM 2926 0D2 ASP B 193 -35. 435 -41.373 -22.286 1, .00 37.34 0
ATOM 2927 C ASP B 193 一 39, 730 -40.115 -23.988 1 • 00 37.77 C ATOM 2928 0 ASP B 193 - 40.931 -39.917 -23.780 1.00 35.55 0ATOM 2927 C ASP B 193 1 39, 730 -40.115 -23.988 1 • 00 37.77 C ATOM 2928 0 ASP B 193-40.931 -39.917 -23.780 1.00 35.55 0
ATOM 2929 N GLN B 194 - 39.274 -40.627 -25.130 1. 00 40.12 NATOM 2929 N GLN B 194-39.274 -40.627 -25.130 1. 00 40.12 N
ATOM 2930 CA GLN B 194 - 40.167 -40.857 -26.264 1. 00 42.05 CATOM 2930 CA GLN B 194-40.167 -40.857 -26.264 1. 00 42.05 C
ATOM 2931 CB GLN B 194 -39.371 -41.244 -27.504 1. 00 44.35 CATOM 2931 CB GLN B 194 -39.371 -41.244 -27.504 1. 00 44.35 C
ATOM 2932 CG GLN B 194 -38.342 -40.227 -27.920 1. 00 50.08 CATOM 2932 CG GLN B 194 -38.342 -40.227 -27.920 1.00 50.08 C
ATOM 2933 CD GLN B 194 -37.479 -40.728 -29.061 1. 00 53.41 CATOM 2933 CD GLN B 194 -37.479 -40.728 -29.061 1. 00 53.41 C
ATOM 2934 0E1 GLN B 194 -37.752 -41.787 -29.641 1. 00 55.01 0ATOM 2934 0E1 GLN B 194 -37.752 -41.787 -29.641 1. 00 55.01 0
ATOM 2935 NE2 GLN B 194 -36.430 -39.972 -29.391 1. 00 54.17 NATOM 2935 NE2 GLN B 194 -36.430 -39.972 -29.391 1. 00 54.17 N
ATOM 2936 C GLN B 194 一 41. 160 -41.963 -25. 956 1. 00 40.82 CATOM 2936 C GLN B 194 1 41. 160 -41.963 -25. 956 1. 00 40.82 C
ATOM 2937 0 GLN B 194 -42. 344 -41.853 - 26. 268 1. 00 41. 13 0ATOM 2937 0 GLN B 194 -42. 344 -41.853-26. 268 1. 00 41. 13 0
ATOM 2938 N GLY B 195 - 40. 661 -43.030 - 25. 345 1. 00 39.96 NATOM 2938 N GLY B 195-40. 661 -43.030-25. 345 1. 00 39.96 N
ATOM 2939 CA 6LY B 195 -41. 491 - 44.177 -25. 042 1. 00 38. 70 CATOM 2939 CA 6LY B 195 -41. 491-44.177 -25. 042 1. 00 38. 70 C
ATOM 2940 C GLY B 195 -40. 626 -45.403 -24. 840 1. 00 39. 37 CATOM 2940 C GLY B 195 -40. 626 -45.403 -24. 840 1. 00 39. 37 C
ATOM 2941 0 GLY B 195 - 39. 412 -45.291 -24. 626 1. 00 36. 23 0ATOM 2941 0 GLY B 195-39. 412 -45.291 -24. 626 1. 00 36. 23 0
ATOM 2942 N LEU B 196 -41. 250 -46.574 - 24. 907 1. 00 40. 83 NATOM 2942 N LEU B 196 -41. 250 -46.574-24. 907 1. 00 40. 83 N
ATOM 2943 CA LEU B 196 -40. 539 -47.834 -24. 730 1. 00 44. 36 CATOM 2943 CA LEU B 196 -40. 539 -47.834 -24. 730 1. 00 44. 36 C
ATOM 2944 CB LEU B 196 -41. 374 - 48.794 -23. 891 1. 00 43. 37 CATOM 2944 CB LEU B 196 -41. 374-48.794 -23. 891 1. 00 43. 37 C
ATOM 2945 CG LEU B 196 -41. 752 -48.306 -22. 495 1. 00 43. 86 GATOM 2945 CG LEU B 196 -41. 752 -48.306 -22. 495 1. 00 43. 86 G
ATOM 2946 CD1 LEU B 196 -42. 586 -49.367 -21. 791 1. 00 42. 63 CATOM 2946 CD1 LEU B 196 -42. 586 -49.367 -21. 791 1. 00 42. 63 C
ATOM 2947 CD2 LEU B 196 -40. 488 -48.015 -21. 713 1. 00 44. 22 CATOM 2947 CD2 LEU B 196 -40. 488 -48.015 -21. 713 1. 00 44. 22 C
ATOM 2948 C LEU B 196 -40. 194 -48.498 -26. 057 1. ,00 46. 33 CATOM 2948 C LEU B 196 -40. 194 -48.498 -26. 057 1., 00 46. 33 C
ATOM 2949 0 LEU B 196 -40. 965 -48.437 -27. 012 1. 00 46. 62 0ATOM 2949 0 LEU B 196 -40. 965 -48.437 -27. 012 1. 00 46. 62 0
ATOM 2950 N ASN B 197 -39. 027 -49.133 -26. 096 1. ,00 50. 07 NATOM 2950 N ASN B 197 -39. 027 -49.133 -26. 096 1., 00 50. 07 N
ATOM 2951 CA ASN B 197 -38. 603 -49.966 -27. 217 1. ,00 53. 61 CATOM 2951 CA ASN B 197 -38. 603 -49.966 -27. 217 1., 00 53. 61 C
ATOM 2952 CB ASN B 197 - 37. 301 -50.688 - 26. 863 1. ,00 53. 45 CATOM 2952 CB ASN B 197-37. 301 -50.688-26. 863 1., 00 53. 45 C
ATOM 2953 CG ASN B 197 - 36. 151 -50.305 -27. 768 1. .00 55. 36 CATOM 2953 CG ASN B 197-36. 151 -50.305 -27. 768 1. .00 55. 36 C
ATOM 2954 0D1 ASN B 197 - 36. 305 -49.496 -28. 688 1. .00 56. 56 0ATOM 2954 0D1 ASN B 197-36. 305 -49.496 -28. 688 1. .00 56. 56 0
ATOM 2955 ND2 ASN B 197 -34. 982 -50.885 -27. 510 1. .00 54. 64 NATOM 2955 ND2 ASN B 197 -34. 982 -50.885 -27. 510 1. .00 54. 64 N
ATOM 2956 C ASN B 197 -39. 647 -51.018 -27. 572 1. .00 57. 69 CATOM 2956 C ASN B 197 -39. 647 -51.018 -27. 572 1. .00 57. 69 C
ATOM 2957 0 ASN B 197 -40. 765 -51.016 -27. 058 1. .00 58. 45 0ATOM 2957 0 ASN B 197 -40. 765 -51.016 -27. 058 1. .00 58. 45 0
ATOM 2958 N GLU B 198 -39. 260 -51.928 -28. 455 1. .00 61. 03 NATOM 2958 N GLU B 198 -39. 260 -51.928 -28. 455 1. .00 61. 03 N
ATOM 2959 CA 6LU B 198 -40. 035 -53.134 -28. 703 1, .00 64. 11 CATOM 2959 CA 6LU B 198 -40. 035 -53.134 -28. 703 1, .00 64. 11 C
ATOM 2960 CB GLU B 198 -39. 442 -53.892 - 29. 895 1. .00 65. 19 CATOM 2960 CB GLU B 198 -39. 442 -53.892-29. 895 1. .00 65. 19 C
ATOM 2961 CG GLU B 198 -37. 969 -54.272 -29. 727 1. .00 68. 83 CATOM 2961 CG GLU B 198 -37. 969 -54.272 -29. 727 1. .00 68. 83 C
ATOM 2962 CD GLU B 198 -37. 014 - 53.093 -29. 894 1, .00 70. 95 CATOM 2962 CD GLU B 198 -37. 014-53.093 -29. 894 1, .00 70. 95 C
ATOM 2963 0E1 GLU B 198 一 35. 796一 53.279 -29. 675 1, .00 71. 38 0 JP2007/071755 ATOM 2963 0E1 GLU B 198 1 35. 796 1 53.279 -29. 675 1, .00 71. 38 0 JP2007 / 071755
ATOM 2964 0E2 6LU B 198 -37.477 -51.983 -30.244 1. 00 71.62 0ATOM 2964 0E2 6LU B 198 -37.477 -51.983 -30.244 1.00 71.62 0
ATOM 2965 C GLU B 198 -39.995 -54.015 -27.452 1. 00 65.19 CATOM 2965 C GLU B 198 -39.995 -54.015 -27.452 1. 00 65.19 C
ATOM 2966 0 GLU B 198 - 40.919 -54.794 -27.191 1. 00 65.15 0ATOM 2966 0 GLU B 198-40.919 -54.794 -27.191 1. 00 65.15 0
ATOM 2967 N HIS B 199 -38.920 -53.878 -26. 679 1. 00 65.91 ΝATOM 2967 N HIS B 199 -38.920 -53.878 -26. 679 1. 00 65.91 Ν
ATOM 2968 GA HIS B 199 -38.707 -54.707 -25. 500 1. 00 66.37 CATOM 2968 GA HIS B 199 -38.707 -54.707 -25. 500 1. 00 66.37 C
ATOM 2969 CB HIS B 199 -37.433 -55.533 -25. 672 1. 00 69.99 CATOM 2969 CB HIS B 199 -37.433 -55.533 -25. 672 1.00 69.99 C
ATOM 2970 C6 HIS B 199 -37.516 -56.541 -26. 776 1. 00 73.69 CATOM 2970 C6 HIS B 199 -37.516 -56.541 -26.776 1.00 73.69 C
ATOM 2971 CD2 HIS B 199 -36.689 -56.794 -27. 819 1. 00 75.49 GATOM 2971 CD2 HIS B 199 -36.689 -56.794 -27. 819 1. 00 75.49 G
ATOM 2972 ND1 HIS B 199 -38.560 -57.434 -26. 890 1. 00 74.98 ΝATOM 2972 ND1 HIS B 199 -38.560 -57.434 -26. 890 1. 00 74.98 Ν
ATOM 2973 CE1 HIS B 199 -38.374 - 58.193 -27. 956 1. 00 76.07 CATOM 2973 CE1 HIS B 199 -38.374-58.193 -27. 956 1. 00 76.07 C
ATOM 2974 NE2 HIS B 199 -37.245 -57.825 -28. 537 1. 00 76.83 ΝATOM 2974 NE2 HIS B 199 -37.245 -57.825 -28. 537 1. 00 76.83 Ν
ATOM 2975 C HIS B 199 -38.632 -53.911 - 24. 198 1. 00 64.51 CATOM 2975 C HIS B 199 -38.632 -53.911-24. 198 1. 00 64.51 C
ATOM 2976 0 HIS B 199 -37.749 -54.137 -23. 374 1. 00 63.85 0ATOM 2976 0 HIS B 199 -37.749 -54.137 -23. 374 1. 00 63.85 0
ATOM 2977 N GLY B 200 -39.561 -52.977 - 24. 025 1. 00 63.20 ΝATOM 2977 N GLY B 200 -39.561 -52.977-24. 025 1. 00 63.20 Ν
ATOM 2978 CA GLY B 200 -39.747 -52.330 -22. 737 1. 00 60.83 CATOM 2978 CA GLY B 200 -39.747 -52.330 -22. 737 1. 00 60.83 C
ATOM 2979 C GLY B 200 - 38.582 -51■ 507 -22. 211 1. 00 58.71 CATOM 2979 C GLY B 200-38.582 -51 507 -22. 211 1. 00 58.71 C
ATOM 2980 0 GLY B 200 -38.531 -51.204 -21. 018 1. 00 59.01 0ATOM 2980 0 GLY B 200 -38.531 -51.204 -21. 018 1. 00 59.01 0
ATOM 2981 N TYR B 201 -37.644 -23. 082 1. 00 55.85 ΝATOM 2981 N TYR B 201 -37.644 -23. 082 1. 00 55.85 Ν
ATOM 2982 CA TYR B 201 -36.542 - 50.275 -22. 680 1. ,00 52.03 CATOM 2982 CA TYR B 201 -36.542-50.275 -22. 680 1., 00 52.03 C
ATOM 2983 CB TYR B 201 -35.239 - 50.732 -23. 336 1. ,00 53.95 CATOM 2983 CB TYR B 201 -35.239-50.732 -23. 336 1., 00 53.95 C
ATOM 2984 CG TYR B 201 -34.854 -52.154 -22. 994 1. ,00 55.96 CATOM 2984 CG TYR B 201 -34.854 -52.154 -22. 994 1., 00 55.96 C
ATOM 2985 CD1 TYR B 201 -35.066 -53.189 -23. 899 1. ,00 56.90 CATOM 2985 CD1 TYR B 201 -35.066 -53.189 -23. 899 1., 00 56.90 C
ATOM 2986 CE1 TYR B 201 -34.737 -54.498 -23.583 1. ,00 57.18 CATOM 2986 CE1 TYR B 201 -34.737 -54.498 -23.583 1., 00 57.18 C
ATOM 2987 CD2 TYR B 201 -34.297 -52.467 - 21. 759 1. .00 56.01 CATOM 2987 CD2 TYR B 201 -34.297 -52.467-21. 759 1. .00 56.01 C
ATOM 2988 CE2 TYR B 201 -33.965 - 53.772 - 21. 434 1. .00 57.03 CATOM 2988 CE2 TYR B 201 -33.965-53.772-21. 434 1. .00 57.03 C
ATOM 2989 CZ TYR B 201 -34.189 - 54.783 -22. 349 1. .00 57.09 CATOM 2989 CZ TYR B 201 -34.189-54.783 -22. 349 1. .00 57.09 C
ATOM 2990 OH TYR B 201 -33.873 -56.083 -22. 023 1, .00 56.96 0ATOM 2990 OH TYR B 201 -33.873 -56.083 -22. 023 1, .00 56.96 0
ATOM 2991 C TYR B 201 -36.832 -48.825 -23. 058 1, .00 49.21 CATOM 2991 C TYR B 201 -36.832 -48.825 -23. 058 1, .00 49.21 C
ATOM 2992 0 TYR B 201 -37.209 -48.530 -24. 195 1, .00 47.53 0ATOM 2992 0 TYR B 201 -37.209 -48.530 -24. 195 1, .00 47.53 0
ATOM 2993 N lLE B 202 - 36.656 -47.925 -22. 095 1, .00 44.81 ΝATOM 2993 N lLE B 202-36.656 -47.925 -22. 095 1, .00 44.81 Ν
ATOM 2994 CA ILE B 202 -36.946 -46.514 - 22. 302 1 .00 41.15 CATOM 2994 CA ILE B 202 -36.946 -46.514-22. 302 1 .00 41.15 C
ATOM 2995 CB ILE B 202 -36.807 -45.728 -20. 996 1 .00 41.04 CATOM 2995 CB ILE B 202 -36.807 -45.728 -20. 996 1 .00 41.04 C
ATOM 2996 CG2 ILE B 202 -37.072 -44.255 -21. 250 1 .00 40.89 CATOM 2996 CG2 ILE B 202 -37.072 -44.255 -21. 250 1 .00 40.89 C
ATOM 2997 C61 ILE B 202 -37.769 -46.281 -19. 949 1 • 00 42.22 CATOM 2997 C61 ILE B 202 -37.769 -46.281 -19. 949 1 • 00 42.22 C
ATOM 2998 CD1 ILE B 202 -37.585 - 45.670 - 18. 564 1 • 00 43.12 CATOM 2998 CD1 ILE B 202 -37.585-45.670-18. 564 1 • 00 43.12 C
ATOM 2999 C ILE B 202 - 35.974 -45.916 -23. ,308 1 .00 39.13 C ATOM 3000 0 ILE B 202 -34.765 - 46.076 -23.171 1.00 38.26 0ATOM 2999 C ILE B 202-35.974 -45.916 -23., 308 1 .00 39.13 C ATOM 3000 0 ILE B 202 -34.765-46.076 -23.171 1.00 38.26 0
ATOM 3001 N ILE B 203 -36.492 -45.226 -24.317 1. 00 37.87 NATOM 3001 N ILE B 203 -36.492 -45.226 -24.317 1. 00 37.87 N
ATOM 3002 CA ILE B 203 -35.615 - 44.501 -25.230 1. 00 38.41 CATOM 3002 CA ILE B 203 -35.615-44.501 -25.230 1. 00 38.41 C
ATOM 3003 CB ILE B 203 -35.650 -45.089 -26.663 1. 00 38.56 CATOM 3003 CB ILE B 203 -35.650 -45.089 -26.663 1. 00 38.56 C
ATOM 3004 C62 ILE B 203 -35.366 -46.585 -26.624 1. 00 38.67 CATOM 3004 C62 ILE B 203 -35.366 -46.585 -26.624 1. 00 38.67 C
ATOM 3005 CG1 ILE B 203 -37.010 - 44.845 -27.303 1. 00 38.11 CATOM 3005 CG1 ILE B 203 -37.010-44.845 -27.303 1. 00 38.11 C
ATOM 3006 CD1 ILE B 203 -37.047 -45.221 -28.764 1. 00 37.85 CATOM 3006 CD1 ILE B 203 -37.047 -45.221 -28.764 1. 00 37.85 C
ATOM 3007 C ILE B 203 -35.961 -43.013 - 25.296 1. 00 38.20 CATOM 3007 C ILE B 203 -35.961 -43.013-25.296 1. 00 38.20 C
ATOM 3008 0 ILE B 203 一 37, 137 -42.629 -25.261 1. 00 37.90 0ATOM 3008 0 ILE B 203 One 37, 137 -42.629 -25.261 1. 00 37.90 0
ATOM 3009 N PRO B 204 -34.932 -42. 152 -25. 378 1. 00 37.34 NATOM 3009 N PRO B 204 -34.932 -42. 152 -25. 378 1. 00 37.34 N
ATOM 3010 CD PRO B 204 -35. 095 - 40. 697 -25. 526 1. 00 35. 96 CATOM 3010 CD PRO B 204 -35. 095-40. 697 -25. 526 1. 00 35. 96 C
ATOM 3011 CA PRO B 204 - 33. 519 -42. 560 -25. 411 1. 00 36. 71 CATOM 3011 CA PRO B 204-33. 519 -42. 560 -25. 411 1. 00 36. 71 C
ATOM 3012 CB PRO B 204 一 32. 772 -41. 260 - 25. 702 1. 00 36. 56 GATOM 3012 CB PRO B 204 One 32. 772 -41. 260-25. 702 1. 00 36. 56 G
ATOM 3013 CG PRO B 204 -33. 716 -40. 172 -25. 296 1. 00 38. 24 CATOM 3013 CG PRO B 204 -33. 716 -40. 172 -25. 296 1. 00 38. 24 C
ATOM 3014 C PRO B 204 -33. 007 -43. 249 -24. 148 1. 00 36. 74 CATOM 3014 C PRO B 204 -33. 007 -43. 249 -24. 148 1. 00 36. 74 C
ATOM 3015 0 PRO B 204 - 32. 015 -43. 974 -24. 195 1. 00 38. 57 0ATOM 3015 0 PRO B 204-32. 015 -43. 974 -24. 195 1. 00 38. 57 0
ATOM 3016 N GLY B 205 -33. 675 -43. 019 - 23. 024 1. .00 36. 16 NATOM 3016 N GLY B 205 -33. 675 -43. 019-23. 024 1. .00 36. 16 N
ATOM 301.7 CA GLY B 205 -33. 394 -43. 785 -21. 821 1. 00 35. 86 CATOM 301.7 CA GLY B 205 -33. 394 -43. 785 -21. 821 1. 00 35. 86 C
ATOM 3018 C GLY B 205 -31. 975 -43. 675 -21. 289 1. ,00 37. 13 CATOM 3018 C GLY B 205 -31. 975 -43. 675 -21. 289 1., 00 37. 13 C
ATOM 3019 0 GLY B 205 - 31. 183 - 42. 856 - 21. 763 1. ,00 38. 33 0ATOM 3019 0 GLY B 205-31. 183-42. 856-21. 763 1., 00 38. 33 0
ATOM 3020 N LEU B 206 -31. 656一 44. 507 -20. 299 1. ,00 35. 80 NATOM 3020 N LEU B 206 -31. 656 1 44. 507 -20. 299 1., 00 35. 80 N
ATOM 3021 GA LEU B 206 - 30. 338 -44. 503 -19. 674 1. ,00 36. 61 CATOM 3021 GA LEU B 206-30. 338 -44. 503 -19. 674 1., 00 36. 61 C
ATOM 3022 CB LEU B 206 -30. 462 -44. 218 -18. 176 1. .00 35. 96 CATOM 3022 CB LEU B 206 -30. 462 -44. 218 -18. 176 1. .00 35. 96 C
ATOM 3023 CG LEU B 206 - 31. 077 -42. 877 -17. 791 1. ,00 36. 85 CATOM 3023 CG LEU B 206-31. 077 -42. 877 -17. 791 1., 00 36. 85 C
ATOM 3024 CD1 LEU B 206 -30. 838 -42. 619 -16. 305 1. .00 35. 29 CATOM 3024 CD1 LEU B 206 -30. 838 -42. 619 -16. 305 1. .00 35. 29 C
ATOM 3025 CD2 LEU B 206 -30. 467 -41. 774 -18. 652 1. .00 34. 83 CATOM 3025 CD2 LEU B 206 -30. 467 -41. 774 -18. 652 1. .00 34. 83 C
ATOM 3026 C LEU B 206 -29. 603 -45. 829 -19. 861 1, .00 37. 57 CATOM 3026 C LEU B 206 -29. 603 -45. 829 -19. 861 1, .00 37. 57 C
ATOM 3027 0 LEU B 206 -28. 419 - 45. 942 -19. 543 1, .00 37. 88 0ATOM 3027 0 LEU B 206 -28. 419-45. 942 -19. 543 1, .00 37. 88 0
ATOM 3028 N GLY B 207 - 30. 304 -46. 835 -20. 365 1, .00 36. 70 NATOM 3028 N GLY B 207-30. 304 -46. 835 -20. 365 1, .00 36. 70 N
ATOM 3029 CA GLY B 207 - 29. 724 -48. 162 -20. 387 1, .00 38. 23 CATOM 3029 CA GLY B 207-29. 724 -48. 162 -20. 387 1, .00 38. 23 C
ATOM 3030 C GLY B 207 -30. 026 -48. 871 -19. 082 1, .00 38. 05 CATOM 3030 C GLY B 207 -30. 026 -48. 871 -19. 082 1, .00 38. 05 C
ATOM 3031 0 GLY B 207 -31. 142 -48. 780 -18. 574 1. .00 39. 70 0ATOM 3031 0 GLY B 207 -31. 142 -48. 780 -18. 574 1. .00 39. 70 0
ATOM 3032 N ASP B 208 -29. 048 -49. 577 -18. 532 1, .00 37. 50 NATOM 3032 N ASP B 208 -29. 048 -49. 577 -18. 532 1, .00 37. 50 N
ATOM 3033 GA ASP B 208 -29. 294 - 50. 328 -17. 311 1, .00 38. 62 CATOM 3033 GA ASP B 208 -29. 294-50. 328 -17. 311 1, .00 38. 62 C
ATOM 3034 CB ASP B 208 -28. 643 -51. 708 -17. 388 1, .00 42. 07 CATOM 3034 CB ASP B 208 -28. 643 -51. 708 -17. 388 1, .00 42. 07 C
ATOM 3035 CG ASP B 208 -29. 444 -52. 767 -16. 646 1, .00 48. 33 C ATOM 3036 0D1 ASP B 208 -30.112 -53.580 -17.324 1.00 51.50 0ATOM 3035 CG ASP B 208 -29. 444 -52. 767 -16. 646 1, .00 48. 33 C ATOM 3036 0D1 ASP B 208 -30.112 -53.580 -17.324 1.00 51.50 0
ATOM 3037 0D2 ASP B 208 -29.410 -52.788 -15.392 1. 00 47.77 0ATOM 3037 0D2 ASP B 208 -29.410 -52.788 -15.392 1. 00 47.77 0
ATOM 3038 C ASP B 208 -28.766 -49.572 -16.101 1. 00 37.03 CATOM 3038 C ASP B 208 -28.766 -49.572 -16.101 1.00 37.03 C
ATOM 3039 0 ASP B 208 -27.632 - 49.774 -15.674 1. 00 36.18 0ATOM 3039 0 ASP B 208 -27.632-49.774 -15.674 1. 00 36.18 0
ATOM 3040 N ALA B 209 - 29.608 -48.710 -15.549 1. 00 34.89 NATOM 3040 N ALA B 209-29.608 -48.710 -15.549 1. 00 34.89 N
ATOM 3041 CA ALA B 209 -29.199 -47.798 - 14. 489 1. 00 34.93 CATOM 3041 CA ALA B 209 -29.199 -47.798-14. 489 1. 00 34.93 C
ATOM 3042 CB ALA B 209 - 30.424 -47.017 -13. 976 1. 00 34.36 CATOM 3042 CB ALA B 209-30.424 -47.017 -13. 976 1.00 34.36 C
ATOM 3043 C ALA B 209 -28.495 -48.509 -13. 326 1. 00 32.81 CATOM 3043 C ALA B 209 -28.495 -48.509 -13. 326 1. 00 32.81 C
ATOM 3044 0 ALA B 209 -27.477 - 48.035 -12. 825 1. 00 31.03 0ATOM 3044 0 ALA B 209 -27.477-48.035 -12. 825 1. 00 31.03 0
ATOM 3045 N GLY B 210 一 29.035 - 49.644 -12. 903 1. 00 30.74 NATOM 3045 N GLY B 210 1 29.035-49.644 -12. 903 1. 00 30.74 N
ATOM 3046 CA GLY B 210 - 28.460 -50.337 - 11. 767 1. 00 30.25 CATOM 3046 CA GLY B 210-28.460 -50.337-11. 767 1.00 30.25 C
ATOM 3047 C GLY B 210 -27.017 - 50.735 - 11. 998 1. 00 32.44 CATOM 3047 C GLY B 210 -27.017-50.735-11. 998 1. 00 32.44 C
ATOM 3048 0 GLY B 210 -26.156 -50.536 -11. 137 1. 00 32.08 0ATOM 3048 0 GLY B 210 -26.156 -50.536 -11. 137 1. 00 32.08 0
ATOM 3049 N ASP B 211 - 26.745 -51.295 -13. 171 1. 00 33.52 NATOM 3049 N ASP B 211-26.745 -51.295 -13. 171 1. 00 33.52 N
ATOM 3050 CA ASP B 211 -25.394 -51.719 -13. 510 1. 00 33.69 CATOM 3050 CA ASP B 211 -25.394 -51.719 -13. 510 1. 00 33.69 C
ATOM 3051 CB ASP B 211 - 25.404 -52.497一 14. 827 1. 00 36.38 CATOM 3051 CB ASP B 211-25.404 -52.497 One 14. 827 1. 00 36.38 C
ATOM 3052 CG ASP B 211 -26.085 -53.845 -14. 703 1. ,00 38.06 CATOM 3052 CG ASP B 211 -26.085 -53.845 -14. 703 1., 00 38.06 C
ATOM 3053 0D1 ASP B 211 -26.007 -54.450 -13. 610 1. 00 39.38 0ATOM 3053 0D1 ASP B 211 -26.007 -54.450 -13. 610 1. 00 39.38 0
ATOM 3054 0D2 ASP B 211 -26.697 -54.299 -15. 699 1. ,00 39.79 0ATOM 3054 0D2 ASP B 211 -26.697 -54.299 -15. 699 1., 00 39.79 0
ATOM 3055 C ASP B 211 - 24.434 -50.530 -13. 614 1. ,00 33.17 CATOM 3055 C ASP B 211-24.434 -50.530 -13. 614 1., 00 33.17 C
ATOM 3056 0 ASP B 211 -23.275 -50.620 -13. 208 1. ,00 32.88 0ATOM 3056 0 ASP B 211 -23.275 -50.620 -13. 208 1., 00 32.88 0
ATOM 3057 N LYS B 212 -24.910 -49.414 -14. 151 1. .00 30.29 NATOM 3057 N LYS B 212 -24.910 -49.414 -14. 151 1. .00 30.29 N
ATOM 3058 CA LYS B 212 -24.059 -48.238 -14.261 1. ,00 31.71 CATOM 3058 CA LYS B 212 -24.059 -48.238 -14.261 1., 00 31.71 C
ATOM 3059 CB LYS B 212 -24.716 -47.188 -15. 161 1. .00 30.20 CATOM 3059 CB LYS B 212 -24.716 -47.188 -15. 161 1. .00 30.20 C
ATOM 3060 CG LYS B 212 - 24.925 - 47.681 -16. 585 1. .00 35.21 CATOM 3060 CG LYS B 212-24.925-47.681 -16. 585 1. .00 35.21 C
ATOM 3061 CD LYS B 212 -25.810 -46.752 -17. 400 1. .00 37.71 CATOM 3061 CD LYS B 212 -25.810 -46.752 -17. 400 1. .00 37.71 C
ATOM 3062 CE LYS B 212 -25.904 -47.209 -18. 851 1. .00 39.83 CATOM 3062 CE LYS B 212 -25.904 -47.209 -18. 851 1. .00 39.83 C
ATOM 3063 NZ LYS B 212 -24.610 -47.033 -19. 578 1. .00 42.00 NATOM 3063 NZ LYS B 212 -24.610 -47.033 -19. 578 1. .00 42.00 N
ATOM 3064 C LYS B 212 -23.779 -47.655 -12. 878 1. .00 31.40 CATOM 3064 C LYS B 212 -23.779 -47.655 -12. 878 1. .00 31.40 C
ATOM 3065 0 LYS B 212 - 22.686一 47.148 -12. 615 1, .00 33.04 0ATOM 3065 0 LYS B 212-22.686 1 47.148 -12. 615 1, .00 33.04 0
ATOM 3066 N ILE B 213 - 24.764 -47.737 -11. 990 1. .00 29.42 NATOM 3066 N ILE B 213-24.764 -47.737 -11. 990 1. .00 29.42 N
ATOM 3067 CA ILE B 213 - 24.590 -47.250 -10. 630 1, .00 31.08 CATOM 3067 CA ILE B 213-24.590 -47.250 -10. 630 1, .00 31.08 C
ATOM 3068 CB ILE B 213 - 25.964 - 47.093 -9. 929 1, .00 29.04 CATOM 3068 CB ILE B 213-25.964-47.093 -9. 929 1, .00 29.04 C
ATOM 3069 CG2 ILE B 213 -25.775 -46.859 -8. 431 1, .00 28.14 CATOM 3069 CG2 ILE B 213 -25.775 -46.859 -8. 431 1, .00 28.14 C
ATOM 3070 CG1 ILE B 213 -26.739 -45.944 -10. 586 1 .00 28.91 CATOM 3070 CG1 ILE B 213 -26.739 -45.944 -10. 586 1 .00 28.91 C
ATOM 3071 CD1 ILE B 213 -28.208一 45.864 -10. 199 1, .00 27.87 C ATOM 3071 CD1 ILE B 213 -28.208 1 45.864 -10. 199 1, .00 27.87 C
11S ATOM 3072 C ILE B 213 -23.685 -48.179 -9.808 1.0031.92 C11S ATOM 3072 C ILE B 213 -23.685 -48.179 -9.808 1.0031.92 C
ATOM 3073 0 ILE B 213 - 22.780 -47.724 -9.107 1. 00 31.94 0ATOM 3073 0 ILE B 213-22.780 -47.724 -9.107 1.00 31.94 0
ATOM 3074 N PHE B 214 -23.924 -49.479 -9.918 1. 00 34.11 NATOM 3074 N PHE B 214 -23.924 -49.479 -9.918 1. 00 34.11 N
ATOM 3075 CA PHE B 214 -23.261 -50.459 -9.069 1. 00 37.24 CATOM 3075 CA PHE B 214 -23.261 -50.459 -9.069 1.00 37.24 C
ATOM 3076 CB PHE B 214 -24.227 -51. 602 -8.747 1. 00 36.73 CATOM 3076 CB PHE B 214 -24.227 -51. 602 -8.747 1. 00 36.73 C
ATOM 3077 CG PHE B 214 - 25.242 -51. 242 - 7.708 1. 00 38.00 CATOM 3077 CG PHE B 214-25.242 -51. 242-7.708 1. 00 38.00 C
ATOM 3078 CD1 PHE B 214 -25.122 -51. 712 -6.411 1. 00 39.50 CATOM 3078 CD1 PHE B 214 -25.122 -51. 712 -6.411 1. 00 39.50 C
ATOM 3079 CD2 PHE B 214 -26.286 -50.384 -8.010 1. 00 36.99 CATOM 3079 CD2 PHE B 214 -26.286 -50.384 -8.010 1.00 36.99 C
ATOM 3080 CE1 PHE B 214 - 26.022 -51. 326 -5.434 1. 00 39.14 CATOM 3080 CE1 PHE B 214-26.022 -51. 326 -5.434 1. 00 39.14 C
ATOM 3081 CE2 PHE B 214 -27.185 -49. 997 -7.039 1. 00 38.10 CATOM 3081 CE2 PHE B 214 -27.185 -49. 997 -7.039 1. 00 38.10 C
ATOM 3082 CZ PHE B 214 - 27.053 - 50. 466 -5.750 1. 00 38.84 CATOM 3082 CZ PHE B 214-27.053-50. 466 -5.750 1. 00 38.84 C
ATOM 3083 C PHE B 214 -51. 019 -9.679 1. 00 39.22 CATOM 3083 C PHE B 214 -51. 019 -9.679 1. 00 39.22 C
ATOM 3084 0 PHE B 214 -21.281 -51. 804 -9.044 1. 00 36.67 0ATOM 3084 0 PHE B 214 -21.281 -51. 804 -9.044 1. 00 36.67 0
ATOM 3085 N 6LY B 215 -21.706 - 50. 608 -10.910 1. 00 42.57 NATOM 3085 N 6LY B 215 -21.706-50. 608 -10.910 1. 00 42.57 N
ATOM 3086 CA 6LY B 215 -20.574 -51. 166 -11.629 1. 00 46.51 CATOM 3086 CA 6LY B 215 -20.574 -51. 166 -11.629 1. 00 46.51 C
ATOM 3087 C GLY B 215 - 20.706 -52. 667 -11.789 1. 00 48.97 CATOM 3087 C GLY B 215-20.706 -52. 667 -11.789 1. 00 48.97 C
ATOM 3088 0 GLY B 215 -19.747 -53. 398 -11.607 1. 00 49.30 0ATOM 3088 0 GLY B 215 -19.747 -53. 398 -11.607 1. 00 49.30 0
ATOM 3089 N THR B 216 -53. 126 -12.131 1. 00 53.33 NATOM 3089 N THR B 216 -53. 126 -12.131 1. 00 53.33 N
ATOM 3090 CA THR B 216 -22.215 -54. 549 -12.126 1. ,00 58.09 CATOM 3090 CA THR B 216 -22.215 -54. 549 -12.126 1., 00 58.09 C
ATOM 3091 CB THR B 216 -23.562 -54. 796 -11.418 1. ,00 58.60 CATOM 3091 CB THR B 216 -23.562 -54. 796 -11.418 1., 00 58.60 C
ATOM 3092 0G1 THR B 216 -23.369 -54. 733 -10.000 1. ,00 58.81 0ATOM 3092 0G1 THR B 216 -23.369 -54. 733 -10.000 1., 00 58.81 0
ATOM 3093 CG2 THR B 216 -24.131 -56. 149 -11.802 1. 00 60.24 CATOM 3093 CG2 THR B 216 -24.131 -56. 149 -11.802 1.00 60.24 C
ATOM 3094 C THR B 216 -22.260 -55. 186 -13.514 1. ,00 60.87 CATOM 3094 C THR B 216 -22.260 -55. 186 -13.514 1., 00 60.87 C
ATOM 3095 0 THR B 216 - 21.899 -56. 350 -13.686 1. ,00 61.47 0ATOM 3095 0 THR B 216-21.899 -56. 350 -13.686 1., 00 61.47 0
ATOM 3096 N LYS B 217 -22.708 -54. 425 -14.503 1. .00 64.94 NATOM 3096 N LYS B 217 -22.708 -54. 425 -14.503 1. .00 64.94 N
ATOM 3097 CA LYS B 217 -22.784 - 54.928 - 15.869 1. .00 68.75 CATOM 3097 CA LYS B 217 -22.784-54.928-15.869 1. .00 68.75 C
ATOM 3098 CB LYS B 217 - 23.920 -55. 951 -15.992 1. .00 70.67 CATOM 3098 CB LYS B 217-23.920 -55. 951 -15.992 1. .00 70.67 C
ATOM 3099 CG LYS B 217 -23.954 - 56. 705 -17.321 1. .00 72.83 CATOM 3099 CG LYS B 217 -23.954-56. 705 -17.321 1. .00 72.83 C
ATOM 3100 CD LYS B 217 -22.621 -57. 386 -17.613 1. .00 74.05 CATOM 3100 CD LYS B 217 -22.621 -57. 386 -17.613 1. .00 74.05 C
ATOM 3101 CE LYS B 217 -22.824 -58. 705 -18.342 1, .00 74.38 CATOM 3101 CE LYS B 217 -22.824 -58. 705 -18.342 1, .00 74.38 C
ATOM 3102 NZ LYS B 217 -23.602 -59. 673 -17.514 1, .00 73.90 NATOM 3102 NZ LYS B 217 -23.602 -59. 673 -17.514 1, .00 73.90 N
ATOM 3103 C LYS B 217 -23.013 -53. 773 -16.840 1, .00 70.04 CATOM 3103 C LYS B 217 -23.013 -53. 773 -16.840 1, .00 70.04 C
ATOM 3104 0 LYS B 217 - 24.116 -53. 705 -17.430 1. .00 70.70 0ATOM 3104 0 LYS B 217-24.116 -53. 705 -17.430 1. .00 70.70 0
ATOM 3105 OXT LYS B 217 - 22.087 - 52. 943 -16.989 1 .00 70.58 0ATOM 3105 OXT LYS B 217-22.087-52. 943 -16.989 1 .00 70.58 0
TER 3106 LYS B 217 TER 3106 LYS B 217
ATOM 3107 CB LYS C 11 -18.803 -15. 715 -32.263 1 .00 38.41 C ATOM 3108 CG LYS C 11 - 17.873 -16.912 - 32.263 1.00 41.03ATOM 3107 CB LYS C 11 -18.803 -15. 715 -32.263 1 .00 38.41 C ATOM 3108 CG LYS C 11-17.873 -16.912-32.263 1.00 41.03
ATOM 3109 CD LYS C 11 -18.005 -17. 703 -33.553 1. 00 44.31ATOM 3109 CD LYS C 11 -18.005 -17. 703 -33.553 1. 00 44.31
ATOM 3110 CE LYS C 11 一 16.909 -18. 747 -33.663 1. 00 45.43ATOM 3110 CE LYS C 11 1 16.909 -18. 747 -33.663 1. 00 45.43
ATOM 3111 NZ LYS C 11 -16.838 -19. 593 -32.440 1. 00 49.14ATOM 3111 NZ LYS C 11 -16.838 -19. 593 -32.440 1. 00 49.14
ATOM 3112 C LYS C 11 - 17.269 -14. 403 - 30.798 1. 00 36.67ATOM 3112 C LYS C 11-17.269 -14. 403-30.798 1. 00 36.67
ATOM 3113 0 LYS C 11 - 16.567 -14. 111 - 31.765 1. 00 37.91ATOM 3113 0 LYS C 11-16.567 -14. 111-31.765 1. 00 37.91
ATOM 3114 N LYS C 11 - 19.679 - 13. 736 -31.063 1. 00 38.03ATOM 3114 N LYS C 11-19.679-13. 736 -31.063 1. 00 38.03
ATOM 3115 CA LYS C 11 -18.712 -14. 876 -30.992 1. 00 37.76ATOM 3115 CA LYS C 11 -18.712 -14. 876 -30.992 1. 00 37.76
ATOM 3116 N ILE C 12 -16.835 -14. 339 -29.543 1. 00 33.84ATOM 3116 N ILE C 12 -16.835 -14. 339 -29.543 1. 00 33.84
ATOM 3117 CA ILE C 12 -15.532 -13. 787 -29.201 1. 00 30.78ATOM 3117 CA ILE C 12 -15.532 -13. 787 -29.201 1. 00 30.78
ATOM 3118 CB ILE C 12 -15.649 -12. 785 -28.040 1. 00 29.95ATOM 3118 CB ILE C 12 -15.649 -12. 785 -28.040 1. 00 29.95
ATOM 3119 CG2 ILE C 12 -14.310 - 12. 151 -27.761 1. 00 27.78ATOM 3119 CG2 ILE C 12 -14.310-12. 151 -27.761 1. 00 27.78
ATOM 3120 CG1 ILE C 12 -16.701 -11. 726 -28.370 1. 00 31.05ATOM 3120 CG1 ILE C 12 -16.701 -11. 726 -28.370 1. 00 31.05
ATOM 3121 CD1 ILE C 12 -16.609 -11. 183 - 29.781 1. 00 34.78ATOM 3121 CD1 ILE C 12 -16.609 -11. 183-29.781 1. 00 34.78
ATOM 3122 C ILE C 12 -14.580一 14. 903 - 28.782 1. 00 31.81ATOM 3122 C ILE C 12 -14.580 One 14. 903-28.782 1. 00 31.81
ATOM 3123 0 ILE C 12 -14.847 -15. 639 -27.827 1. 00 32.24ATOM 3123 0 ILE C 12 -14.847 -15. 639 -27.827 1. 00 32.24
ATOM 3124 N VAL C 13 -13.463 -15. 021 -29.491 1. 00 30.09ATOM 3124 N VAL C 13 -13.463 -15. 021 -29.491 1. 00 30.09
ATOM 3125 CA VAL C 13 -12.547 -16. 133 -29.279 1. 00 28.85ATOM 3125 CA VAL C 13 -12.547 -16. 133 -29.279 1. 00 28.85
ATOM 3126 CB VAL C 13 -12.405 - 16. 966 -30.561 1. ,00 29.94ATOM 3126 CB VAL C 13 -12.405-16. 966 -30.561 1., 00 29.94
ATOM 3127 CG1 VAL C 13 -11 · 441 -18. 117 - 30.328 1. ,00 30.27ATOM 3127 CG1 VAL C 13 -11 441 -18. 117-30.328 1., 00 30.27
ATOM 3128 CG2 VAL C 13 -13.779 -17. 470 -31.010 1. ,00 28.73ATOM 3128 CG2 VAL C 13 -13.779 -17. 470 -31.010 1., 00 28.73
ATOM 3129 C VAL C 13 -15. 631 -28.883 1. ,00 28.44ATOM 3129 C VAL C 13 -15. 631 -28.883 1., 00 28.44
ATOM 3130 0 VAL C 13 -10.527 - 14. 934 -29'· 654 1. .00 29.69ATOM 3130 0 VAL C 13 -10.527-14. 934 -29 '· 654 1. .00 29.69
ATOM 3131 N GLU C 14 -10.715 -15. 978 - 27.684 1, .00 28.01ATOM 3131 N GLU C 14 -10.715 -15. 978-27.684 1, .00 28.01
ATOM 3132 CA GLU c 14 -9.312 -15. 774 -27.332 1. .00 30.01ATOM 3132 CA GLU c 14 -9.312 -15. 774 -27.332 1. .00 30.01
ATOM 3133 CB GLU c 14 -9.174 -15. 383 -25.857 1, .00 30.39ATOM 3133 CB GLU c 14 -9.174 -15. 383 -25.857 1, .00 30.39
ATOM 3134 CG GLU c 14 -7.733 -15. 111 -25.433 1, .00 33.76ATOM 3134 CG GLU c 14 -7.733 -15. 111 -25.433 1, .00 33.76
ATOM 3135 CD GLU c 14 -7.597 -14. 769 -23.960 1 .00 33.44ATOM 3135 CD GLU c 14 -7.597 -14. 769 -23.960 1 .00 33.44
ATOM 3136 0E1 GLU c 14 -8.593 -14. 878 - 23.218 1, .00 38.19ATOM 3136 0E1 GLU c 14 -8.593 -14. 878-23.218 1, .00 38.19
ATOM- 3137 0E2 GLU c 14 -6.489 -14. 389 - 23.539 1, .00 35.80ATOM- 3137 0E2 GLU c 14 -6.489 -14. 389-23.539 1, .00 35.80
ATOM 3138 C GLU c 14 -8.518 —17. 056 -27.601 1 .00 29.55ATOM 3138 C GLU c 14 -8.518 --17. 056 -27.601 1 .00 29.55
ATOM 3139 0 GLU c 14 -8.687 -18. 052 -26.897 1 ■ 00 30.66ATOM 3139 0 GLU c 14 -8.687 -18. 052 -26.897 1 ■ 00 30.66
ATOM 3140 N VAL c 15 -7.657 -17. 028 -28.619 1 .00 28.51ATOM 3140 N VAL c 15 -7.657 -17. 028 -28.619 1 .00 28.51
ATOM 3141 CA VAL c 15 -6.889 - 18. 210 -29.011 1 .00 25.40ATOM 3141 CA VAL c 15 -6.889-18. 210 -29.011 1 .00 25.40
ATOM 3142 CB VAL c 15 -6.187 -17. 998 -30.370 1 .00 26.36ATOM 3142 CB VAL c 15 -6.187 -17. 998 -30.370 1 .00 26.36
ATOM 3143 CG1 VAL c 15 -5.281 -19. 197一 30, 682 1 .00 20.35 ATOM 3144 CG2 VAL C 15 -7.234 -17.800 -31.471 1.0024.9.1 CATOM 3143 CG1 VAL c 15 -5.281 -19. 197 one 30, 682 1 .00 20.35 ATOM 3144 CG2 VAL C 15 -7.234 -17.800 -31.471 1.0024.9.1 C
ATOM 3145 C VAL C 15 -5.831 -18. 562一 27. 965 1.00 26.23 CATOM 3145 C VAL C 15 -5.831 -18. 562 27. 965 1.00 26.23 C
ATOM 3146 0 VAL C 15 -4.975 -17. 748 -27. 636 1 · 0027.43 0ATOM 3146 0 VAL C 15 -4.975 -17. 748 -27. 636 1 0027.43 0
ATOM 3147 N LYS C 16 -5.892 -19. 782 -27. 452 1.00 24.25 NATOM 3147 N LYS C 16 -5.892 -19. 782 -27. 452 1.00 24.25 N
ATOM 3148 CA LYS G 16 -5.067 - 20. 160 -26. 318 1.00 26.70 CATOM 3148 CA LYS G 16 -5.067-20. 160 -26. 318 1.00 26.70 C
ATOM 3149 CB LYS C 16 -5.937 -20. 815 -25. 244 1.00 28.15 CATOM 3149 CB LYS C 16 -5.937 -20. 815 -25. 244 1.00 28.15 C
ATOM 3150 CG LYS C 16 -7.116 - 19. 955 -24. 816 1.0034.22 CATOM 3150 CG LYS C 16 -7.116-19. 955 -24. 816 1.0034.22 C
ATOM 3151 CD LYS C 16 -7.019 -19. 551 -23. 362 1.00 34.49 CATOM 3151 CD LYS C 16 -7.019 -19. 551 -23. 362 1.00 34.49 C
ATOM 3152 CE LYS C 16 -7.994 -18. 431 -23. 057 1.0039.70 CATOM 3152 CE LYS C 16 -7.994 -18. 431 -23. 057 1.0039.70 C
ATOM 3153 NZ LYS C 16 -8.120 -18. 168 -21. 595 1.00 39.90 NATOM 3153 NZ LYS C 16 -8.120 -18. 168 -21.595 1.00 39.90 N
ATOM 3154 C LYS C 16 -3.926 -21. 097 -26. 698 1.00 24.66 GATOM 3154 C LYS C 16 -3.926 -21. 097 -26. 698 1.00 24.66 G
ATOM 3155 .0 LYS C 16 -3.151 -21. 519 - 25. 841 1.00 24.95 0ATOM 3155 .0 LYS C 16 -3.151 -21. 519-25. 841 1.00 24.95 0
ATOM 3156 N HIS C 17 -3.835 -21. 422 -27. 982 1.00 23.42 . NATOM 3156 N HIS C 17 -3.835 -21. 422 -27. 982 1.00 23.42 .N
ATOM 3157 CA HIS C 17 -2.782 -22. 284 -28. 500 1.00 22.18 CATOM 3157 CA HIS C 17 -2.782 -22. 284 -28. 500 1.00 22.18 C
ATOM 3158 CB HIS C 17 -2.849 -22. 297 - 30. 029 1.00 22.79 CATOM 3158 CB HIS C 17 -2.849 -22. 297-30. 029 1.00 22.79 C
ATOM 3159 C6 HIS C 17 -2.026 -23. 374 - 30. 665 1.0022.34 CATOM 3159 C6 HIS C 17 -2.026 -23. 374-30. 665 1.0022.34 C
ATOM 3160 CD2 HIS C 17 -2.383 - 24. 421 -31. 446 1.00 19.14 CATOM 3160 CD2 HIS C 17 -2.383-24. 421 -31. 446 1.00 19.14 C
ATOM 3161 ND1 HIS C 17 -0.652 - 23. 429 - 30. 549 1.00 21.78 NATOM 3161 ND1 HIS C 17 -0.652-23. 429-30. 549 1.00 21.78 N
ATOM 3162 CE1 HIS C 17 -0.200 -24. 465 - 31. 235 1.00 20.73 CATOM 3162 CE1 HIS C 17 -0.200 -24. 465-31. 235 1.00 20.73 C
ATOM 3163 NE2 HIS G 17 -1.229 - 25. 082 -31. 788 1.00 21.28 NATOM 3163 NE2 HIS G 17 -1.229-25. 082 -31. 788 1.00 21.28 N
ATOM 3164 C HIS C 17 -1.402 -21. 811 -28. 037 1.00 22.85 CATOM 3164 C HIS C 17 -1.402 -21. 811 -28. 037 1.00 22.85 C
ATOM 3165 0 HIS C 17 -1.095 - 20. 619 -28. 057 1.00 24.07 0ATOM 3165 0 HIS C 17 -1.095-20. 619 -28. 057 1.00 24.07 0
ATOM 3166 N PRO C 18 -0.548 -22. 750 -27. 613 1.00 22.74 NATOM 3166 N PRO C 18 -0.548 -22. 750 -27. 613 1.00 22.74 N
ATOM 3167 CD PRO C 18 -0.744 -24. 209 -27. 671 1.00 19.87 CATOM 3167 CD PRO C 18 -0.744 -24. 209 -27. 671 1.00 19.87 C
ATOM 3168 CA PRO C 18 0.716 -22. 382 -26. 965 1.00 21.07 CATOM 3168 CA PRO C 18 0.716 -22. 382 -26. 965 1.00 21.07 C
ATOM 3169 CB PRO C 18
Figure imgf000117_0001
-23. 719 -26. 492 1.00 21.29 CATOM 3169 CB PRO C 18
Figure imgf000117_0001
-23. 719 -26. 492 1.00 21.29 C
ATOM 3170 CG PRO C 18 0.615 -24. 746 -27. 364 1.00 19.48 CATOM 3170 CG PRO C 18 0.615 -24. 746 -27. 364 1.00 19.48 C
ATOM 3171 C PRO C 18 1.701 -21. 613一 27. 844 1.00 21.38 CATOM 3171 C PRO C 18 1.701 -21.613 one 27.844 1.00 21.38 C
ATOM 3172 0 PRO G 18 2.518 - 20. 856 - 27. 329 1.00 22.29 0ATOM 3172 0 PRO G 18 2.518-20. 856-27. 329 1.00 22.29 0
ATOM 3173 N LEU C 19 1.633 - 21. 797 -29. 157 1.00 20.50 NATOM 3173 N LEU C 19 1.633-21. 797 -29. 157 1.00 20.50 N
ATOM 3174 CA LEU e 19 2.482 -21. 016 - 30. 058 1.00.21.76 CATOM 3174 CA LEU e 19 2.482 -21. 016-30. 058 1.00.21.76 C
ATOM 3175 CB LEU c 19 2.477 -21. 614 -31. 466 1.00 19.87 CATOM 3175 CB LEU c 19 2.477 -21. 614 -31. 466 1.00 19.87 C
ATOM 3176 CG LEU c 19 3.066 -23. 013 -31. 645 1.00 20.40 CATOM 3176 CG LEU c 19 3.066 -23. 013 -31. 645 1.00 20.40 C
ATOM 3177 CD1 LEU c 19 3.101 -23. 344 -33. 131 1.00 18.35 CATOM 3177 CD1 LEU c 19 3.101 -23. 344 -33. 131 1.00 18.35 C
ATOM 3178 CD2 LEU c 19 4.464 -23. 076 -31. 034 1.00 17.59 CATOM 3178 CD2 LEU c 19 4.464 -23. 076 -31. 034 1.00 17.59 C
ATOM 3179 C LEU c 19 2.020 -19. 560 -30. 136 1.00 24.38 C ATOM 3180 0 LEU C 19 2.835 -18.631 -30.186 1.00 27.96 0ATOM 3179 C LEU c 19 2.020 -19. 560 -30. 136 1.00 24.38 C ATOM 3180 0 LEU C 19 2.835 -18.631 -30.186 1.00 27.96 0
ATOM 3181 N. VAL C 20 0. 709 -19.355 -30. 157 1. 00 24.79 ΝATOM 3181 N. VAL C 20 0. 709 -19.355 -30. 157 1. 00 24.79 Ν
ATOM 3182 CA VAL C 20 0. 179 -18.003 -30. 122 1. 00 23.50 CATOM 3182 CA VAL C 20 0. 179 -18.003 -30. 122 1. 00 23.50 C
ATOM 3183 CB VAL C 20 - 1. 355 -18.014 -30. 182 1. 00 21. 60 CATOM 3183 CB VAL C 20-1. 355 -18.014 -30. 182 1. 00 21. 60 C
ATOM 3184 C61 VAL C 20 -1. 876 -16.618 -30. 068 1. 00 22.91 CATOM 3184 C61 VAL C 20 -1. 876 -16.618 -30. 068 1. 00 22.91 C
ATOM 3185 CG2 VAL C 20 - 1. 818 -18.644 -31. 481 1. 00 14.04 CATOM 3185 CG2 VAL C 20-1. 818 -18.644 -31. 481 1. 00 14.04 C
ATOM 3186 C VAL C 20 0. 648 -17.359 -28. 825 1. 00 24.87 GATOM 3186 C VAL C 20 0. 648 -17.359 -28. 825 1. 00 24.87 G
ATOM 3187 0 VAL C 20 1. 240 -16.284 - 28. 836 1. 00 25.22 0ATOM 3187 0 VAL C 20 1. 240 -16.284-28. 836 1. 00 25.22 0
ATOM 3188 N LYS C 21 0. 422 -18.047 -27. 708 1. 00 26. 13 ΝATOM 3188 N LYS C 21 0. 422 -18.047 -27. 708 1. 00 26. 13 Ν
ATOM 3189 CA LYS C 21 0. 829 -17.534 -26. 404 1. 00 25. 78 CATOM 3189 CA LYS C 21 0. 829 -17.534 -26. 404 1. 00 25. 78 C
ATOM 3190 CB LYS C 21 0. 553 -18.570 -25. 319 1. 00 28. 09 CATOM 3190 CB LYS C 21 0. 553 -18.570 -25. 319 1. 00 28. 09 C
ATOM 3191 CG LYS C 21 - 0· 905 -18. 717 -24. 925 1. 00 29. 54 CATOM 3191 CG LYS C 21-0 · 905 -18. 717 -24. 925 1. 00 29. 54 C
ATOM 3192 CD LYS G 21 - 1. 026 -19. 730 -23. 793 1. 00 32. 86 CATOM 3192 CD LYS G 21-1. 026 -19. 730 -23. 793 1. 00 32. 86 C
ATOM 3193 CE LYS C 21 - 2. 417 -19. 726 -23. 169 1. 00 37. 22 CATOM 3193 CE LYS C 21-2. 417 -19. 726 -23. 169 1. 00 37. 22 C
ATOM 3194 NZ LYS C 21 -2. 911 -21. 116 -22. 909 1. 00 37. 82 ΝATOM 3194 NZ LYS C 21 -2. 911 -21. 116 -22. 909 1. 00 37. 82 Ν
ATOM 3195 C LYS C 21 2. 306 - 17. 191 -26. 392 1. 00 25. 85 CATOM 3195 C LYS C 21 2. 306-17. 191 -26. 392 1. 00 25. 85 C
ATOM 3196 0 LYS C 21 2. 717 一 16. 151 -25. 873 1. 00 25. 55 0ATOM 3196 0 LYS C 21 2. 717 One 16. 151 -25. 873 1. 00 25. 55 0
ATOM 3197 N HIS C 22 3. 104 -18. 082 -26. 969 1. ,00 25. 86 ΝATOM 3197 N HIS C 22 3. 104 -18. 082 -26. 969 1., 00 25. 86 Ν
ATOM 3198 CA HIS C 22 4.551 -17. 939 - 26. 955 1. ,00 23. 39 CATOM 3198 CA HIS C 22 4.551 -17. 939-26. 955 1., 00 23. 39 C
ATOM 3199 CB HIS C 22 5. 204 - 19. 232 -27. 477 1. 00 24. 00 CATOM 3199 CB HIS C 22 5. 204-19. 232 -27. 477 1. 00 24. 00 C
ATOM 3200 CG HIS C 22 6. 666 -19. 098 -27. 780 1. .00 23. 48 CATOM 3200 CG HIS C 22 6. 666 -19. 098 -27. 780 1. .00 23. 48 C
ATOM 3201 CD2 HIS C 22 7. 312 - 18. 825 - 28. 938 1. ,00 23. 90 CATOM 3201 CD2 HIS C 22 7. 312-18. 825-28. 938 1., 00 23. 90 C
ATOM 3202 ND1 HIS c 22 7. 644 -19. 231 -26.817 1. .00 25. 11 ΝATOM 3202 ND1 HIS c 22 7. 644 -19. 231 -26.817 1. .00 25. 11 Ν
ATOM 3203 CE1 HIS c 22 8. 829 -19. 042 -27. 370 1. ,00 26. 40 CATOM 3203 CE1 HIS c 22 8. 829 -19. 042 -27. 370 1., 00 26. 40 C
ATOM 3204 NE2 HIS c 22 8. 655 -18. 795 -28. 656 1. ,00 24. 39 ΝATOM 3204 NE2 HIS c 22 8. 655 -18. 795 -28. 656 1., 00 24. 39 Ν
ATOM 3205 C HIS c 22 4. 952 -16. 748 -27. 820 1. .00 22. 14 CATOM 3205 C HIS c 22 4. 952 -16. 748 -27. 820 1. .00 22. 14 C
ATOM 3206 0 HIS c 22 5. 720 -15. 888 - 27. 397 1. .00 23. 44 0ATOM 3206 0 HIS c 22 5. 720 -15. 888-27. 397 1. .00 23. 44 0
ATOM 3207 N LYS c 23 4. 415 -16. 692 -29. 029 1. .00 22. 82 ΝATOM 3207 N LYS c 23 4. 415 -16. 692 -29. 029 1. .00 22. 82 Ν
ATOM 3208 CA LYS c 23 4. 827 -15. 669 - 29. 976 1. .00 25. 27 CATOM 3208 CA LYS c 23 4. 827 -15. 669-29. 976 1. .00 25. 27 C
ATO 3209 CB LYS c 23 4. 306 -16. 013 -31. 369 1, .00 25. 02 CATO 3209 CB LYS c 23 4. 306 -16. 013 -31. 369 1, .00 25. 02 C
ATOM 3210 CG LYS c 23 4. 973 -17. 247 -31. 967 1, .00 24. 27 CATOM 3210 CG LYS c 23 4. 973 -17. 247 -31. 967 1, .00 24. 27 C
ATOM 3211 CD LYS c 23 4. 332 -17. 647 -33. 284 1. .00 22. 96 CATOM 3211 CD LYS c 23 4. 332 -17. 647 -33. 284 1. .00 22. 96 C
ATOM 3212 CE LYS c 23 4. 917 -18. 943 -33. 815 1, .00 25. 14 CATOM 3212 CE LYS c 23 4. 917 -18. 943 -33. 815 1, .00 25. 14 C
ATOM 3213 NZ LYS c 23 6. 326 -18. 815 -34. 305 1, .00 22. 73 ΝATOM 3213 NZ LYS c 23 6. 326 -18. 815 -34. 305 1, .00 22. 73 Ν
ATOM 3214 C LYS c 23 4. 344 -14. 290 -29. 549 1, .00 26. 46 CATOM 3214 C LYS c 23 4. 344 -14. 290 -29. 549 1, .00 26. 46 C
ATOM 3215 0 LYS c 23 5. 073 -13. 305 -29. 680 1, .00 29. 63 0 ATOM 3216 N LEU C 24 3.126一 14.226 - 29.020 1.00 26.36 NATOM 3215 0 LYS c 23 5. 073 -13. 305 -29. 680 1, .00 29. 63 0 ATOM 3216 N LEU C 24 3.126 One 14.226-29.020 1.00 26.36 N
ATOM 3217 CA LEU C 24 2.571 -12.974 -28. 518 1. 00 26.28 CATOM 3217 CA LEU C 24 2.571 -12.974 -28. 518 1. 00 26.28 C
ATOM 3218 CB LEU C 24 1.079 -13.156 -28. 208 1. 00 26.85 CATOM 3218 CB LEU C 24 1.079 -13.156 -28. 208 1. 00 26.85 C
ATOM 3219 CG LEU C 24 0.187 -11. 961 -27. 830 1. 00 29.49 CATOM 3219 CG LEU C 24 0.187 -11. 961 -27. 830 1. 00 29.49 C
ATOM 3220 CD1 LEU C 24 0.488 -11. 525 -26. 420 1. 00 29.60 CATOM 3220 CD1 LEU C 24 0.488 -11. 525 -26. 420 1. 00 29.60 C
ATOM 3221 GD2 LEU C 24 0.384 -10.814 -28. 809 1. 00 29.92 CATOM 3221 GD2 LEU C 24 0.384 -10.814 -28. 809 1. 00 29.92 C
ATOM 3222 C LEU C 24 3.329 -12. 525 -27. 268 1. 00 25.83 CATOM 3222 C LEU C 24 3.329 -12. 525 -27. 268 1. 00 25.83 C
ATOM 3223 0 LEU C 24 3.635 -11. 345 -27. 107 1. 00 27.61 0ATOM 3223 0 LEU C 24 3.635 -11. 345 -27. 107 1. 00 27.61 0
ATOM 3224 N 6LY C 25 3.647 -13. 462 -26. 387 1. 00 25.02 NATOM 3224 N 6LY C 25 3.647 -13. 462 -26. 387 1. 00 25.02 N
ATOM 3225 CA GLY C 25 4.409 -13. 101 -25. 204 1. 00 24.00 GATOM 3225 CA GLY C 25 4.409 -13. 101 -25. 204 1. 00 24.00 G
ATOM 3226 C 6LY C 25 5.734 -12. 421 -25. 527 1. 00 24.16 CATOM 3226 C 6LY C 25 5.734 -12. 421 -25. 527 1. 00 24.16 C
ATOM 3227 .0 GLY C 25 6.120 -11. 462 -24. 863 1. 00 26.23 0ATOM 3227 .0 GLY C 25 6.120 -11. 462 -24. 863 1. 00 26.23 0
ATOM 3228 N LEU C 26 6.441 -12. 903 -26. 543 1. 00 21.83 NATOM 3228 N LEU C 26 6.441 -12. 903 -26. 543 1. 00 21.83 N
ATOM 3229 CA LEU C 26 7.710 -12. 285 -26. 920 1. 00 22.30 CATOM 3229 CA LEU C 26 7.710 -12. 285 -26. 920 1. 00 22.30 C
ATOM 3230 CB LEU C 26 8.377 -13. 075 - 28. 048 1. 00 19.90 CATOM 3230 CB LEU C 26 8.377 -13. 075-28. 048 1.00 19.90 C
ATOM 3231 CG LEU C 26 8.940 -14. 447 - 27. 666 1. 00 21.82 CATOM 3231 CG LEU C 26 8.940 -14. 447-27. 666 1. 00 21.82 C
ATOM 3232 CD1 LEU C 26 9.473 - 15. 157 -28. 909 1. 00 20.00 CATOM 3232 CD1 LEU C 26 9.473-15. 157 -28. 909 1.00 20.00 C
ATOM 3233 CD2 LEU C 26 10.042 —14. 268 -26. 626 1. 00 19.33 CATOM 3233 CD2 LEU C 26 10.042 —14. 268 -26. 626 1. 00 19.33 C
ATOM 3234 C LEU C 26 7.532 -10. 825 - 27. 357 1. 00 22.54 CATOM 3234 C LEU C 26 7.532 -10. 825-27. 357 1. 00 22.54 C
ATOM 3235 0 LEU C 26 8.411 -9. 991 -27. 129 1. 00 21.69 0ATOM 3235 0 LEU C 26 8.411 -9. 991 -27. 129 1. 00 21.69 0
ATOM 3236 N MET C 27 6.395 -10. 520 -27. 975 1. 00 21.36 NATOM 3236 N MET C 27 6.395 -10. 520 -27. 975 1. 00 21.36 N
ATOM 3237 CA MET C 27 6.156 - 9. 178 -28. 506 1. 00 23.85 CATOM 3237 CA MET C 27 6.156-9. 178 -28. 506 1. 00 23.85 C
ATOM 3238 CB MET C 27 .4.864 - 9. 146 - 29L 328 1. ,00 20.66 CATOM 3238 CB MET C 27 .4.864-9. 146-29L 328 1., 00 20.66 C
ATOM 3239 CG MET C 27 4.893 -10. 096 -30. 501 1. ,00 18.99 CATOM 3239 CG MET C 27 4.893 -10. 096 -30. 501 1., 00 18.99 C
ATOM 3240 SD MET C 27 3.533 -9. 873 -31. 631 1. ,00 22.53 SATOM 3240 SD MET C 27 3.533 -9. 873 -31. 631 1., 00 22.53 S
ATOM 3241 CE MET C 27 3.825 -8. 167 -32. 166 1. ,00 22.44 CATOM 3241 CE MET C 27 3.825 -8. 167 -32. 166 1., 00 22.44 C
ATOM 3242 C MET C 27 6.087 -8. 139 -27. 398 1. ,00 24.79 CATOM 3242 C MET C 27 6.087 -8. 139 -27. 398 1., 00 24.79 C
ATOM 3243 0 MET c 27 6.264 -6. 947 -27. 652 1. ,00 25.33 0ATOM 3243 0 MET c 27 6.264 -6. 947 -27. 652 1., 00 25.33 0
ATOM 3244 N ARG c 28 5.846 -8. 601 -26. 172 1. .00 24.81 NATOM 3244 N ARG c 28 5.846 -8. 601 -26. 172 1. .00 24.81 N
ATOM 3245 CA ARG c 28 5.750 -7. 722 -25. 013 1. .00 25.76 CATOM 3245 CA ARG c 28 5.750 -7. 722 -25. 013 1. .00 25.76 C
ATOM 3246 CB ARG c 28 5.006 -8. 438 -23. 877 1. ,00 25.31 CATOM 3246 CB ARG c 28 5.006 -8. 438 -23. 877 1., 00 25.31 C
ATOM 3247 CG ARG c 28 3.595 -8. 910 -24. 236 1. .00 23.46 GATOM 3247 CG ARG c 28 3.595 -8. 910 -24. 236 1. .00 23.46 G
ATOM 3248 CD ARG c 28 2.785 - 9. 122 - 22. 976 1. .00 27.66 CATOM 3248 CD ARG c 28 2.785-9. 122-22. 976 1. .00 27.66 C
ATOM 3249 NE ARG c 28 1.573 -9, 915 -23. 170 1, .00 27.29 NATOM 3249 NE ARG c 28 1.573 -9, 915 -23. 170 1, .00 27.29 N
ATOM 3250 CZ ARG c 28 0.396 - 9. 411 -23. 524 1. .00 28.01 CATOM 3250 CZ ARG c 28 0.396-9. 411 -23. 524 1. .00 28.01 C
ATOM 3251 NH1 ARG G 28 0.266 -8. 110一 23, 737 1, .00 27.16 N ATOM 3252 NH2 ARG C 28 -0.658 -10.206 -23.645 1.00 27.59 ΝATOM 3251 NH1 ARG G 28 0.266 -8. 110 1 23, 737 1, .00 27.16 N ATOM 3252 NH2 ARG C 28 -0.658 -10.206 -23.645 1.00 27.59 Ν
ATOM 3253 C ARG C 28 7.124 -7. 258 -24. 517 1.00 26.79 CATOM 3253 C ARG C 28 7.124 -7. 258 -24. 517 1.00 26.79 C
ATOM 3254 0 ARG C 28 7.220 -6.386 -23. 653 1. 00 26.86 0ATOM 3254 0 ARG C 28 7.220 -6.386 -23. 653 1. 00 26.86 0
ATOM 3255 N GLU C 29 8.177 -7. 850 - 25. 070 1. 00 29.47 ΝATOM 3255 N GLU C 29 8.177 -7. 850-25. 070 1. 00 29.47 Ν
ATOM 3256 CA GLU C 29 9.548 - 7. 639 -24. 608 1. 00 33.79 CATOM 3256 CA GLU C 29 9.548-7. 639 -24. 608 1.00 33.79 C
ATOM 3257 CB GLU C 29 10.509 -8.437 -25. 494 1. 00 36.95 CATOM 3257 CB GLU C 29 10.509 -8.437 -25. 494 1. 00 36.95 C
ATOM 3258 CG GLU C 29 11.499 -9.337 -24. 759 1. 00 42.00 CATOM 3258 CG GLU C 29 11.499 -9.337 -24. 759 1. 00 42.00 C
ATOM 3259 CD GLU C 29 12.034 -10.462 -25. 647 1. 00 44.20 CATOM 3259 CD GLU C 29 12.034 -10.462 -25. 647 1. 00 44.20 C
ATOM 3260 0E1 GLU C 29 -10.512 -26. 847 1. 00 44.20 0ATOM 3260 0E1 GLU C 29 -10.512 -26. 847 1. 00 44.20 0
ATOM 3261 0E2 GLU C 29 12.812 - 11. 302 -25. 145 1. 00 46.91 0ATOM 3261 0E2 GLU C 29 12.812-11. 302 -25. 145 1. 00 46.91 0
ATOM 3262 C GLU C 29 9.941 一 6.162 - 24. 646 1. 00 36.17 CATOM 3262 C GLU C 29 9.941 One 6.162-24. 646 1. 00 36.17 C
ATOM 3263 0 GLU C 29 9.810 - 5.500 -25. 673 1. 00 33.36 0ATOM 3263 0 GLU C 29 9.810-5.500 -25. 673 1. 00 33.36 0
ATOM 3264 N GLN C 30 10.445 -5. 663 -23. 524 1. 00 40.57 ΝATOM 3264 N GLN C 30 10.445 -5. 663 -23. 524 1. 00 40.57 Ν
ATOM 3265 CA GLN C 30 10.806 -4. 256 -23. 388 1. 00 45.37 CATOM 3265 CA GLN C 30 10.806 -4. 256 -23. 388 1. 00 45.37 C
ATOM 3266 CB GLN G 30 11.574 -4. 036 - 22. 086 1. 00 47.67 CATOM 3266 CB GLN G 30 11.574 -4. 036-22. 086 1. 00 47.67 C
ATOM 3267 CG GLN C 30 12.056 -2. 604 -21. 891 1. 00 52.21 CATOM 3267 CG GLN C 30 12.056 -2. 604 -21. 891 1. 00 52.21 C
ATOM 3268 CD GLN C 30 13.041 -2. 480 - 20. 741 1. 00 53.91 CATOM 3268 CD GLN C 30 13.041 -2. 480-20. 741 1. 00 53.91 C
ATOM 3269 0E1 GLN C 30 14.236 - 2. 740 -20. 902 1. 00 53.33 0ATOM 3269 0E1 GLN C 30 14.236-2. 740 -20. 902 1. 00 53.33 0
ATOM 3270 NE2 GLN C 30 12.541 - 2. 084 - 19. 571 1. 00. 53.93 ΝATOM 3270 NE2 GLN C 30 12.541-2. 084-19. 571 1. 00. 53.93 Ν
ATOM 3271 C GLN C 30 11.640 - 3. 706 -24. 542 1. 00 46.26 CATOM 3271 C GLN C 30 11.640-3. 706 -24. 542 1. 00 46.26 C
ATOM 3272 0 GLN C 30 11.314 - 2. 664 -25. 107 1. .00 48.72 0ATOM 3272 0 GLN C 30 11.314-2. 664 -25. 107 1. .00 48.72 0
ATOM 3273 N ASP C 31 12.721 -4. 392 - 24. 884 1. 00 46.60 ΝATOM 3273 N ASP C 31 12.721 -4. 392-24. 884 1. 00 46.60 Ν
ATOM 3274 CA ASP C 31 Ϊ3.659 -3. 851 -25.858 1. ,00 48.84 CATOM 3274 CA ASP C 31 Ϊ3.659 -3. 851 -25.858 1., 00 48.84 C
ATOM 3275 CB ASP C 31 15.090 - 3. 934 -25. 314 1. ,00 52.15 CATOM 3275 CB ASP C 31 15.090-3. 934 -25. 314 1., 00 52.15 C
ATOM 3276 CG ASP C 31 15.628 -2. 576 -24. 893 1. ,00 55.71 CATOM 3276 CG ASP C 31 15.628 -2. 576 -24. 893 1., 00 55.71 C
ATOM 3277 0D1 ASP c 31 15.087 -1. 552 -25. 372 1, .00 56.76 0ATOM 3277 0D1 ASP c 31 15.087 -1. 552 -25. 372 1, .00 56.76 0
ATOM 3278 0D2 ASP c 31 16.587 -2. 529 -24. 089 1. .00 58.07 .0ATOM 3278 0D2 ASP c 31 16.587 -2. 529 -24. 089 1. .00 58.07 .0
ATOM 3279 C ASP c 31 13.584 一 4. 535 - 27. 218 1. .00 47.54 CATOM 3279 C ASP c 31 13.584 One 4. 535-27. 218 1. .00 47.54 C
ATOM 3280 0 ASP c 31 14.524 一 4. 464 -28. 007 1. .00 47.73 0ATOM 3280 0 ASP c 31 14.524 One 4.464 -28.007 1..00 47.73 0
ATOM 3281 N ILE c 32 12.457 -5. 186 -27. 488 1. .00 45.31 ΝATOM 3281 N ILE c 32 12.457 -5. 186 -27. 488 1. .00 45.31 Ν
ATOM 3282 CA ILE c 32 12.290 -5. 958 -28. 710 1. .00 41.08 CATOM 3282 CA ILE c 32 12.290 -5. 958 -28. 710 1. .00 41.08 C
ATOM 3283 CB ILE G 32 10.880 - 6. 571 - 28. 780 1. .00 38.93 CATOM 3283 CB ILE G 32 10.880-6. 571-28. 780 1. .00 38.93 C
ATOM 3284 CG2 ILE C 32 9.838 -5. 466 -28. 826 1, .00 39.14 CATOM 3284 CG2 ILE C 32 9.838 -5. 466 -28. 826 1, .00 39.14 C
ATOM 3285 CG1 ILE C 32 10.764 -7. 468 -30. 008 1, .00 37.31 CATOM 3285 CG1 ILE C 32 10.764 -7. 468 -30. 008 1, .00 37.31 C
ATOM 3286 CD1 ILE c 32 9.429 -8. 138 - 30. 138 1, .00 37.58 CATOM 3286 CD1 ILE c 32 9.429 -8. 138-30. 138 1, .00 37.58 C
ATOM 3287 C ILE c 32 12.530 -5. 091 -29. 948 1, .00 40.05 C ATOM 3288 0 ILE C 32 12.158 -3.916 - 29.982 1.00 40.91ATOM 3287 C ILE c 32 12.530 -5. 091 -29. 948 1, .00 40.05 C ATOM 3288 0 ILE C 32 12.158 -3.916-29.982 1.00 40.91
ATOM 3289 N SER C 33 13.158 -5.684 -30.959 1. 00 37.41ATOM 3289 N SER C 33 13.158 -5.684 -30.959 1. 00 37.41
ATOM 3290 CA SER c 33 13.622 -4.941 - 32.123 1. 00 34.25ATOM 3290 CA SER c 33 13.622 -4.941-32.123 1. 00 34.25
ATOM 3291 CB SER c 33 14.865 -5.613 - 32.704 1. 00 35.48ATOM 3291 CB SER c 33 14.865 -5.613-32.704 1. 00 35.48
ATOM 3292 OG SER c 33 14.515 -6.766 -33.456 1. 00 37.39ATOM 3292 OG SER c 33 14.515 -6.766 -33.456 1. 00 37.39
ATOM 3293 C SER c 33 12.548 -4.857 -33.202 1. 00 33.30ATOM 3293 C SER c 33 12.548 -4.857 -33.202 1. 00 33.30
ATOM 3294 0 SER c 33 11.647 - 5.692 - 33.267 1. 00 32.71ATOM 3294 0 SER c 33 11.647-5.692-33.267 1. 00 32.71
ATOM 3295 N TH c 34 12.655 - 3.848 -34.056 1. 00 32.93ATOM 3295 N TH c 34 12.655-3.848 -34.056 1. 00 32.93
ATOM 3296 CA THR c 34 11,689 - 3.655 -35.123 1. 00 33.10ATOM 3296 CA THR c 34 11,689-3.655 -35.123 1. 00 33.10
ATOM 3297 CB THR c 34 12.117 -2.521 -36.061 1. 00 34.55ATOM 3297 CB THR c 34 12.117 -2.521 -36.061 1.00 34.55
ATOM 3298 061 THR c 34 12.230 -1.302 -35.317 1. 00 37.05ATOM 3298 061 THR c 34 12.230 -1.302 -35.317 1.00 37.05
ATOM 3299 CG2 THR c 34 11.093 -2.337 -37.163 1: 00 34.56ATOM 3299 CG2 THR c 34 11.093 -2.337 -37.163 1: 00 34.56
ATOM 3300 C THR c 34 11.520 -4.918 -35.951 1. 00 33.59ATOM 3300 C THR c 34 11.520 -4.918 -35.951 1.00 33.59
ATOM 3301 0 THR c 34 10.397 -5.306 -36.276 1. 00 34.39ATOM 3301 0 THR c 34 10.397 -5.306 -36.276 1.00 34.39
ATOM 3302 N LYS c 35 12.632 -5.566 -36.292 1. 00 33.34ATOM 3302 N LYS c 35 12.632 -5.566 -36.292 1. 00 33.34
ATOM 3303 CA LYS c 35 12.570 -6.775 - 37.106 1. 00 31.25ATOM 3303 CA LYS c 35 12.570 -6.775-37.106 1. 00 31.25
ATOM 3304 CB LYS c 35 13.981 - 7.287 -37.419 1. 00 31.60ATOM 3304 CB LYS c 35 13.981-7.287 -37.419 1. 00 31.60
ATOM 3305 CG LYS c 35 13.973 - 8.533 -38.299 1. ,00 30.89ATOM 3305 CG LYS c 35 13.973-8.533 -38.299 1., 00 30.89
ATOM 3306 CD LYS c 35 15.368 -8.957 -38.701 1. 00. 34.56ATOM 3306 CD LYS c 35 15.368 -8.957 -38.701 1. 00. 34.56
ATOM 3307 CE LYS c 35 15.317 -10.141 -39.643 1. ,00 31.86ATOM 3307 CE LYS c 35 15.317 -10.141 -39.643 1., 00 31.86
ATOM 3308 NZ LYS c 35 14.420 -11.202 -39.114 1. .00 35.45ATOM 3308 NZ LYS c 35 14.420 -11.202 -39.114 1. .00 35.45
ATOM 3309 C LYS c 35 11.768 -7.884 -36.409 1. ,00 29.22ATOM 3309 C LYS c 35 11.768 -7.884 -36.409 1., 00 29.22
ATOM 3310 0 LYS c 35 10.853 -8.473 -36.990 1. .00 22.71ATOM 3310 0 LYS c 35 10.853 -8.473 -36.990 1. .00 22.71
ATOM 3311 N ARG c 36 12.117 -8.157 -35.160 1. .00 28.76ATOM 3311 N ARG c 36 12.117 -8.157 -35.160 1. .00 28.76
ATOM 3312 CA ARG c 36 11.481 -9.238 -34.419 1, .00 31.57ATOM 3312 CA ARG c 36 11.481 -9.238 -34.419 1, .00 31.57
ATOM 3313 CB ARG c 36 12.150 - 9.377 - 33.050 1. .00 33.57ATOM 3313 CB ARG c 36 12.150-9.377-33.050 1. .00 33.57
ATOM 3314 CG ARG c 36 12.177 - 10.794 -32.507 1, .00 43.50ATOM 3314 CG ARG c 36 12.177-10.794 -32.507 1, .00 43.50
ATOM 3315 CD ARG c 36 13.567 - 11.136 -31.963 1. .00 49.88ATOM 3315 CD ARG c 36 13.567-11.136 -31.963 1. .00 49.88
ATOM 3316 NE ARG c 36 14.178 -9.997 - 31.276 1, .00 54.09ATOM 3316 NE ARG c 36 14.178 -9.997-31.276 1, .00 54.09
ATOM 3317 CZ ARG c 36 15.157 -9.246 -31.779 1, .00 56.41ATOM 3317 CZ ARG c 36 15.157 -9.246 -31.779 1, .00 56.41
ATOM 3318 NH1 ARG c 36 15.636 -8.228 -31.076 1, .00 57.17ATOM 3318 NH1 ARG c 36 15.636 -8.228 -31.076 1, .00 57.17
ATOM 3319 NH2 ARG c 36 15.668 -9.515 -32.975 1 .00 56.45ATOM 3319 NH2 ARG c 36 15.668 -9.515 -32.975 1 .00 56.45
ATOM 3320 C ARG c 36 9.985 -8.954 - 34.258 1 .00 30.45ATOM 3320 C ARG c 36 9.985 -8.954-34.258 1 .00 30.45
ATOM 3321 0 ARG c 36 9.150 -9.799 -34.565 1 .00 29.01ATOM 3321 0 ARG c 36 9.150 -9.799 -34.565 1 .00 29.01
ATOM 3322 N PHE c 37 9.654 -7.748 -33.803 1 .00 30.90ATOM 3322 N PHE c 37 9.654 -7.748 -33.803 1 .00 30.90
ATOM 3323 CA PHE c 37 8.262 - 7.365 -33.578 1 .00 28.28 0 L0"93 00· ι 8½ ε- 619 Ofr 0 Π31 0 6SSS WOIVATOM 3323 CA PHE c 37 8.262-7.365 -33.578 1 .00 28.28 0 L0 "93 00 · ι 8½ ε- 619 Ofr 0 Π31 0 6 SSS WOIV
0 L9'92 001 ι 96 ,ζε - Z.69'8L- 99^ 'Z. 017 0 nai 300 89εε IN01V0 L9'92 00 1 ι 96, ζε-Z.69'8L- 99 ^ 'Z. 017 0 nai 300 89εε IN01V
0 00' ι 6ΐε ,LS - 0 'は- SOL '8 0 nai LOO ζ.9εε WOIV0 00 'ι 6ΐε, LS-0' is SOL '8 0 nai LOO ζ.9εε WOIV
0 6S "83 00' V εο9 Ζ£- ん 80 'ZL- 'ん O 0 Π3Ί 90 99εε IN01V0 6S "83 00 'V εο9 80 £-80' ZL- 'O 0 Π3Ί 90 99εε IN01V
0 00' V 960 ■εε - 08fr - 1 L - 9ΐε-9 O 0 nai ao 99εε W01V0 00 'V 960 εε-08fr-1 L-9ΐε-9 O 0 nai ao 99εε W01V
0 16 00' Ί ΖΖ ε- 068."- 0fr6 '3 O 0 Π31 VO ½εε W01V0 16 00 'Ί ε ε- 068. "-0fr6' 3 O 0 Π31 VO ½εε W01V
N ε'92 00' L 89t- ■9ε- - - U6 '9 Ofr 0 Π3Ί N ε9ε IN01V ό 91. '62 00 'ι 913 L€- OBI ·9 6 0 Π19 0 W01VN ε'92 00 'L 89t- ■ 9ε---U6' 9 Ofr 0 Π3Ί N ε9ε IN01V ό 91. '62 00 'ι 913 L €-OBI 9 6 0 Π19 0 W01V
0 Z0 6Z 00' L 63ん ■9ε - Z.2Z.-U- Ζ96 "9 6 0 mo 0 W01V0 Z0 6Z 00 'L 63 9ε-Z.2Z.-U- Ζ96 "9 6 0 mo 0 W01V
0 ん 00' L εεζ '6ε - 6εε ·νι- 9WTLL 6ε 0 niD 330 09εε W01V0 0 00 'L εεζ' 6ε-6εε νι- 9WTLL 6ε 0 niD 330 09εε W01V
0 00 L 91L ·6ε - 091 l- 998 ·8 6ε 0 niD L30 6½ε W01V0 00 L 91L 6ε-091 l- 998 8 6ε 0 niD L30 6½ε W01V
0 6 -n 00 . 800 6ε- ZL9 ΈΙ- 600 ΌΙ 6ε 0 me ao 8^ W01V0 6 -n 00 .800 6ε- ZL9 ΈΙ- 600 ΌΙ 6ε 0 me ao 8 ^ W01V
0 00 ι 989 8ε- 302 τι- ZLl OL 6ε 0 ma 90 mz W01V0 00 ι 989 8ε- 302 τι- ZLl OL 6ε 0 ma 90 mz W01V
0 00 ■ί ns■ ι L - Z.8 "6 6ε 0 HID ao 9½ε INOIV0 00 ■ ί ns ■ ι L-Z.8 "6 6ε 0 HID ao 9½ε INOIV
0 69 ι 00 ι 989 ζ.ε- ηΐ'ΐι- L90'8 6 0 Π19 VO 9^ W01V0 69 ι 00 ι 989 ζ.ε- ηΐ'ΐι- L90'8 6 0 Π19 VO 9 ^ W01V
N 93 63 00 . ■ζ.ε- L69 "6- S6l "8 6ε 0 mo N ^ε IN01VN 93 63 00 .ζ.ε- L69 "6- S6l" 8 6ε 0 mo N ^ ε IN01V
0 9 'οε 00 •ι 916 ,乙 ε- P5Z '6- 80 ·9 8 0 0 ε εε ΙΛΙΟ丄 V0 9 'οε 00 • ι 916, B ε- P5Z' 6- 80 9 8 0 0 ε εε ΙΛΙΟ 丄 V
0 86 '83 00 ■ι SZ9 ■.ε- 998.8 - SZ.L 'し 8ε 0 〇 ζ ζ W01V0 86 '83 00 ■ ι SZ9 ■ .ε- 998.8-SZ.L '8ε 0 ○ ζ ζ W01V
N LL '8 00 L οιν Vi■ L - 8 0 ZHN W01VN LL '8 00 L οιν Vi ■ L-8 0 ZHN W01V
N 6S'L£ 00 ■ι 89 L Z.9L Έ - LZZ'ii βε 0 LHN om W01VN 6S'L £ 00 ■ ι 89 L Z.9L Έ-LZZ'ii βε 0 LHN om W01V
0 89 9 00 ■!■ Z.6L .0ヤ- 60 ·τ- 686 '6 βε 0 10 6εεε WOIV0 89 9 00 ■! ■ Z.6L .0 YA-60 ・ τ-686 '6 βε 0 10 6εεε WOIV
N 83'9S 00 •1 910 ■O - 9 s ε- Z.Z.6 '8 8ε 0 HV 、 3N βεεε WOIVN 83'9S 00 • 1 910 O-9 s ε- Z.Z.6 '8 8ε 0 HV, 3N βεεε WOIV
0 L 'εε 00 ■L 89 ■6S- 0Ζ.6 - 93 L ·6 8ε 0 9¾iV ao εεε WOIV0 L 'εε 00 ■ L 89 ■ 6S- 0Ζ.6-93 L 6 8ε 0 9¾iV ao εεε WOIV
0 n ·εε 00 •ι 86^ ■8ε - Lん ε '9- 30fr ·8 βε 0 D¾V DO 9εεε IN01V0 n · εε 00 • ι 86 ^ ∎8ε-L ε '9-30fr · 8 βε 0 D¾V DO 9εεε IN01V
〇 9に οε 00 06S ■8ε - 898 ·9 - 6εε·8 8 0 9MV 90' 9εεε WOIV〇 9 and οε 00 06S 8ε-898 9-6εε8 8 0 9MV 90 '9εεε WOIV
0 00 ■1 083 LZ- S8C■ん- 8ε 0 OW VO ½ WOIV0 00 1 083 LZ-S8C 8/8 0 OW VO ½ WOIV
N L9' .3 00 ■ι LZ.6 ■9ε- zn 'L - L30'8 8ε 0 9¾JV N εεεε 1N01VN L9 '.3 00 ■ ι LZ.6 ■ 9ε-zn' L-L30'8 8ε 0 9¾JV N εεεε 1N01V
0 9CZ.2 00 'L 608 ε- 090 "8- 90S '9 L 0 3Hd 0 ζεεε WOIV0 9CZ.2 00 'L 608 ε- 090 "8- 90S' 9 L 0 3Hd 0 ζεεε WOIV
0 89 '82 00 ■L 8f8 ε - 8fr9 'L- on'L LZ 0 3Hd 0 ιεεε WOIV0 89 '82 00 L 8f8 ε-8fr9 'L- on'L LZ 0 3Hd 0 ιεεε WOIV
〇 ZL 'LZ 00 ■L 90S "ΐε- LL8 - 19 LZ 0 3Hd zo οεεε WOIV〇 ZL 'LZ 00 L 90S "ΐε- LL8-19 LZ 0 3Hd zo οεεε WOIV
0 ·%ζ 00 ■L ε99 ■ζε - 6 9 - L99 ε 0 3Hd 330 6ζεε IN01V0% ζ 00 ∎L ε99 ∎ζε-6 9-L99 ε 0 3Hd 330 6ζεε IN01V
0 Z 'LZ 00 Ί S99 'οε - ん Sfr .S- S9fr'9 L£ 0 3Hd L30 2ΖΖΖ WOIV0 Z 'LZ 00 Ί S99' οε-N Sfr .S- S9fr'9 L £ 0 3Hd L30 2ΖΖΖ WOIV
0 Ζ6 '9Ζ 00 ■1 ζζ ·εε - 386 - 898 'S LZ 0 3Hd ZQO LZZZ WOIV0 Ζ6 '9Ζ 00 1 1 ζζεε-386-898' S LZ 0 3Hd ZQO LZZZ WOIV
0 9L 'S3 00 ■L τη ■ιε- L9L "S- ん 99 '9 ん ε 0 3Hd iao 93εε INOiV0 9L 'S3 00 ■ L τη ■ ιε- L9L "S- 99 99' 9 ε 0 3Hd iao 93εε INOiV
0 LZ S3 00 ■L 9 'S- 288 ·9 0 3Hd 90 εε WOIV0 LZ S3 00 L 9 'S- 288 9 0 3Hd 90 εε WOIV
0 19 - Z 00 ■1 εζι ,εε— L16.S— LSI '8 ん ε D 3Hd ao WOIV 0 19-Z 00 ■ 1 εζι, εε— L16.S— LSI '8 ε D 3Hd ao WOIV
SSZ. 0/Z.00idf/X3d 0 ん S0/600 OAV ATOM 3360 0 LEU C 40 3.568 -12.211 -34.683 1.00 28.99 0SSZ. 0 / Z.00idf / X3d 0 S0 / 600 OAV ATOM 3360 0 LEU C 40 3.568 -12.211 -34.683 1.00 28.99 0
ATOM 3361 N ALA G 41 4.374 -10.209 - 35.323 1. 00 25.24 NATOM 3361 N ALA G 41 4.374 -10.209-35.323 1.00 25.24 N
ATOM 3362 CA ALA C 41 3.069 -9.678 -35.682 1. 00 23.26 CATOM 3362 CA ALA C 41 3.069 -9.678 -35.682 1. 00 23.26 C
ATOM 3363 CB ALA C 41 3.205 -8.235 -36.147 1. 00 22.59 CATOM 3363 CB ALA C 41 3.205 -8.235 -36.147 1.00 22.59 C
ATOM 3364 C ALA C 41 2.455 -10.523 -36.793 1. 00 24.89 CATOM 3364 C ALA C 41 2.455 -10.523 -36.793 1.00 24.89 C
ATOM 3365 0 ALA C 41 1.290 -10.939 - 36.714 1. 00 23.76 0ATOM 3365 0 ALA C 41 1.290 -10.939-36.714 1.00 23.76 0
ATOM 3366 N SER C 42 3.246 -10.782 - 37.828 1. 00 23.52 NATOM 3366 N SER C 42 3.246 -10.782-37.828 1. 00 23.52 N
ATOM 3367 CA SER C 42 2.772 - 11. 575 -38.952 1. 00 24.09 CATOM 3367 CA SER C 42 2.772-11. 575 -38.952 1. 00 24.09 C
ATOM 3368 CB SER C 42 3.759 -11. 493 - 40. 108 1. 00 23.78 CATOM 3368 CB SER C 42 3.759 -11. 493-40. 108 1. 00 23.78 C
ATOM 3369 OG SER C 42 3.069 - 11. 098 -41. 276 1. 00 30.23 0ATOM 3369 OG SER C 42 3.069-11. 098 -41. 276 1. 00 30.23 0
ATOM 3370 C SER G 42 2.541 -13.039 -38. 581 1. 00 22. 77 CATOM 3370 C SER G 42 2.541 -13.039 -38. 581 1. 00 22. 77 C
ATOM 3371 '0 ； SER C 42 1.564 - 13.648 - 39. 015 1. 00 21. 25 0ATOM 3371 '0 SER C 42 1.564-13.648-39. 015 1. 00 21. 25 0
ATOM 3372 N . 6LU C 43 3.432 -13. 593 -37. 769 1. 00 21. 44 NATOM 3372 N. 6LU C 43 3.432 -13. 593 -37. 769 1. 00 21. 44 N
ATOM 3373 CA GLU C 43 3.311 -14. 982 - 37. 351 1. 00 24. 94 CATOM 3373 CA GLU C 43 3.311 -14. 982-37. 351 1. 00 24. 94 C
ATOM 3374 CB GLU C 43 4.504 - 15. 380 -36. 463 1. 00 25. 49 CATOM 3374 CB GLU C 43 4.504-15. 380 -36. 463 1. 00 25. 49 C
ATOM 3375 CG GLU C 43 5.804 -15. 581 -37. 235 1. 00 24. 79 CATOM 3375 CG GLU C 43 5.804 -15. 581 -37. 235 1. 00 24. 79 C
ATOM 3376 CD GLU C 43 6.984 -15. 952 - 36. 349 1. 00 24. 72 CATOM 3376 CD GLU C 43 6.984 -15. 952-36. 349 1. 00 24. 72 C
ATOM 3377 0E1 GLU C 43 6.766 -16. 496 - 35. 250 1. 00 26. 17 0ATOM 3377 0E1 GLU C 43 6.766 -16. 496-35. 250 1. 00 26. 17 0
ATOM 3378 0E2 GLU C 43 8.137 -15. 697 -36. 755 1. ,00. 27. 47 0ATOM 3378 0E2 GLU C 43 8.137 -15. 697 -36. 755 1., 00. 27. 47 0
ATOM 3379 C GLU C 43 1.999 -15. 200 -36. 602 1. ,00 24. 32 CATOM 3379 C GLU C 43 1.999 -15. 200 -36. 602 1., 00 24. 32 C
ATOM 3380 0 GLU C 43 1.199 -16. 060 -36. 971 1. ,00 25. 03 0ATOM 3380 0 GLU C 43 1.199 -16. 060 -36. 971 1., 00 25. 03 0
ATOM 3381 N VAL C 44 1.769 -14. 407 -35. 560 1. ,00 24. 79 NATOM 3381 N VAL C 44 1.769 -14. 407 -35. 560 1., 00 24. 79 N
ATOM 3382 CA VAL G 44 0.544 -14. 526 -34. 781 1. ,00 22. 14 CATOM 3382 CA VAL G 44 0.544 -14. 526 -34. 781 1., 00 22. 14 C
ATOM 3383 CB VAL C 44 0.558 - 13. 569 -33. 572 1. .00 22. 23 CATOM 3383 CB VAL C 44 0.558-13. 569 -33. 572 1. .00 22. 23 C
ATOM 3384 CG1 VAL C 44 -0.759 -13. 638 -32. 825 1. ,00 18. 47 CATOM 3384 CG1 VAL C 44 -0.759 -13. 638 -32. 825 1., 00 18. 47 C
ATOM 3385 CG2 VAL C 44 1.698 -13. 943 -32. 652 1. .00 18. 00 CATOM 3385 CG2 VAL C 44 1.698 -13. 943 -32. 652 1. .00 18. 00 C
ATOM 3386 C VAL G 44 -0.651 -14. 227 -35. 659 1. .00 23. 03 CATOM 3386 C VAL G 44 -0.651 -14. 227 -35. 659 1. .00 23. 03 C
ATOM 3387 0 VAL C 44 -1 · 705 -14. 832 -35. 506 1. .00 23. 81 0ATOM 3387 0 VAL C 44 -1 705 -14. 832 -35. 506 1. .00 23. 81 0
ATOM 3388 N GLY C 45 -0.472 -13. 300 -36. 596 1. .00 24. 22 NATOM 3388 N GLY C 45 -0.472 -13. 300 -36. 596 1. .00 24. 22 N
ATOM 3389 CA GLY C 45 -1.526 -12. 998 -37. 545 1. .00 21. 28 CATOM 3389 CA GLY C 45 -1.526 -12. 998 -37. 545 1. .00 21. 28 C
ATOM 3390 C GLY C 45 -1.886 -14. 219 -38. 359 1. .00 20. 94 CATOM 3390 C GLY C 45 -1.886 -14. 219 -38. 359 1. .00 20. 94 C
ATOM 3391 0 GLY C 45 -3.064 -14. 534 -38. 540 1, .00 21. 16 0ATOM 3391 0 GLY C 45 -3.064 -14. 534 -38. 540 1, .00 21. 16 0
ATOM 3392 N SER C 46 -0.871 - 14. 917 -38. 853 1. .00 20. 42 NATOM 3392 N SER C 46 -0.871-14. 917 -38. 853 1. .00 20. 42 N
ATOM 3393 CA SER C 46 -1.093 -16. 146 -39. 599 1, .00 19. 90 CATOM 3393 CA SER C 46 -1.093 -16. 146 -39. 599 1, .00 19. 90 C
ATOM 3394 CB SER C 46 0.241 -16. 762 -40. 013 1. .00 19. 39 CATOM 3394 CB SER C 46 0.241 -16. 762 -40. 013 1. .00 19. 39 C
ATOM 3395 06 SER C 46 0.015 -17. 996 -40. 668 1, .00 22. 06 0 ATOM 3396 C SER C 46 -1.885 -17.177 -38.788 1.00 19.99 CATOM 3395 06 SER C 46 0.015 -17. 996 -40. 668 1, .00 22. 06 0 ATOM 3396 C SER C 46 -1.885 -17.177 -38.788 1.00 19.99 C
ATOM 3397 0 SER C 46 -2.853 -17.749 -39.277 1. 00 23.21 0ATOM 3397 0 SER C 46 -2.853 -17.749 -39.277 1.00 23.21 0
ATOM 3398 N LEU C 47 -1.475 - 17.414 -37.550 1. 00 20.20 NATOM 3398 N LEU C 47 -1.475-17.414 -37.550 1.00 20.20 N
ATOM 3399 GA LEU C 47 - 2.166 -18.387 -36.716 1. 00 22.19 CATOM 3399 GA LEU C 47-2.166 -18.387 -36.716 1. 00 22.19 C
ATOM 3400 CB LEU C 47 -1.394 -18.582 -35.405 1. 00 23.38 CATOM 3400 CB LEU C 47 -1.394 -18.582 -35.405 1. 00 23.38 C
ATOM 3401 CG LEU C 47 0.041 -19.088一 35, 614 1. 00 23.73 CATOM 3401 CG LEU C 47 0.041 -19.088 One 35, 614 1. 00 23.73 C
ATOM 3402 CD1 LEU C 47 0.635 -19.542 - 34.290 1. 00 24.10 CATOM 3402 CD1 LEU C 47 0.635 -19.542-34.290 1. 00 24.10 C
ATOM 3403 CD2 LEU C 47 0.037 -20.239 -36.619 1. 00 21.42 CATOM 3403 CD2 LEU C 47 0.037 -20.239 -36.619 1.00 21.42 C
ATOM 3404 C LEU C 47 - 3.624 -17.987 -36.437 1. 00 22.67 CATOM 3404 C LEU C 47-3.624 -17.987 -36.437 1. 00 22.67 C
ATOM 3405 0 LEU C 47 -4.518 -18.839 -36.426 1. 00 19.11 0ATOM 3405 0 LEU C 47 -4.518 -18.839 -36.426 1. 00 19.11 0
ATOM 3406 N LEU C 48 -3.866 -16.691 -36.240 1. 00 22.02 NATOM 3406 N LEU C 48 -3.866 -16.691 -36.240 1.00 22.02 N
ATOM 3407 ,CA LEU C 48 -5.225 -16.211 - 36.028 1. 00 22.54 CATOM 3407, CA LEU C 48 -5.225 -16.211-36.028 1. 00 22.54 C
ATOM 3408 CB LEU C 48 -5.203 -14.722一 35.689 1. 00 22.02 CATOM 3408 CB LEU C 48 -5.203 -14.722 1 35.689 1. 00 22.02 C
ATOM 3409 CG LEU C 48 - 4.678 -14.390 -34.291 1. 00 22.66 CATOM 3409 CG LEU C 48-4.678 -14.390 -34.291 1.00 22.66 C
ATOM 3410 CD1 LEU C 48 -4.759 -12.892 -34.055 1. 00 22.26 CATOM 3410 CD1 LEU C 48 -4.759 -12.892 -34.055 1. 00 22.26 C
ATOM 3411 CD2 LEU C 48 -5.503一 15.130 -33.252 1. 00 19.79 CATOM 3411 CD2 LEU C 48 -5.503 1 15.130 -33.252 1. 00 19.79 C
ATOM 3412 C LEU C 48 -6.117 -16.462 - 37.243 1. 00 23.04 CATOM 3412 C LEU C 48 -6.117 -16.462-37.243 1. 00 23.04 C
ATOM 3413 0 LEU c 48 -7.302 -16.785 -37.111 1. 00 22.83 0ATOM 3413 0 LEU c 48 -7.302 -16.785 -37.111 1.00 22.83 0
ATOM 3414 N THR c 49 -5.538 -16.328 - 38.430 1. 00 23.55 NATOM 3414 N THR c 49 -5.538 -16.328-38.430 1. 00 23.55 N
ATOM 3415 CA THR c 49 - 6.272 - 16.548 -39.664 1. ,00 23.20 CATOM 3415 CA THR c 49-6.272-16.548 -39.664 1., 00 23.20 C
ATOM 3416 CB THR c 49 -5.383 -16.287 -40.888 1. 00 24.81 CATOM 3416 CB THR c 49 -5.383 -16.287 -40.888 1.00 24.81 C
ATOM 3417 061 THR c 49 -4.996 -14.907 -40.915 1. ,00 26.77 0ATOM 3417 061 THR c 49 -4.996 -14.907 -40.915 1., 00 26.77 0
ATOM 3418 CG2 THR c 49 -6.126 -16.648 -42.173 1. .00 22.01 CATOM 3418 CG2 THR c 49 -6.126 -16.648 -42.173 1. .00 22.01 C
ATOM 3419 C THR c 49 -6.755 - 17.987 -39.733 1. ,00 24.32 CATOM 3419 C THR c 49 -6.755-17.987 -39.733 1., 00 24.32 C
ATOM 3420 0 THR c 49 -7.847 -18.275 -40.239 1. ,00 23.52 0ATOM 3420 0 THR c 49 -7.847 -18.275 -40.239 1., 00 23.52 0
ATOM 3421 N TYR c 50 -5.924 -18.891 -39.229 1. .00 25.28 NATOM 3421 N TYR c 50 -5.924 -18.891 -39.229 1. .00 25.28 N
ATOM 3422 CA TYR c 50 -6.221 -20.315 -39.300 1. .00 26.92 CATOM 3422 CA TYR c 50 -6.221 -20.315 -39.300 1. .00 26.92 C
ATOM 3423 CB TYR c 50 -5.015 -21.119 -38.809 1. .00 27.99 CATOM 3423 CB TYR c 50 -5.015 -21.119 -38.809 1. .00 27.99 C
ATOM 3424 CG TYR c 50 - 5.185 -22.611 -38.899 1. .00 26.77 CATOM 3424 CG TYR c 50-5.185 -22.611 -38.899 1. .00 26.77 C
ATOM 3425 CD1 TYR c 50 -5.150 -23.257 -40.125 1, .00 29.74 GATOM 3425 CD1 TYR c 50 -5.150 -23.257 -40.125 1, .00 29.74 G
ATOM 3426 CE1 TYR c 50 - 5.288 - 24.630 -40.214 1. .00 29.59 CATOM 3426 CE1 TYR c 50-5.288-24.630 -40.214 1. .00 29.59 C
ATOM 3427 CD2 TYR c 50 -5.366 -23.376 -37.763 1, .00 28.16 CATOM 3427 CD2 TYR c 50 -5.366 -23.376 -37.763 1, .00 28.16 C
ATOM 3428 CE2 TYR c 50 - 5.509 -24.747 - 37.843 1, .00 28.32 CATOM 3428 CE2 TYR c 50-5.509 -24.747-37.843 1, .00 28.32 C
ATOM 3429 CZ TYR c 50 -5.469 -25.366 -39.070 1, .00 28.11 CATOM 3429 CZ TYR c 50 -5.469 -25.366 -39.070 1, .00 28.11 C
ATOM 3430 OH TYR c 50 -5.637 - 26.723 -39.159 1, .00 30.80 0ATOM 3430 OH TYR c 50 -5.637-26.723 -39.159 1, .00 30.80 0
ATOM 3431 C TYR c 50 - 7.433 -20.587一 38.420 1, .00 27.07 C 5 ATOM 3431 C TYR c 50-7.433 -20.587 One 38.420 1, .00 27.07 C Five
ATOM 3432 0 TYR C 50 -8.410 -21.203 -38.844 1. 00 26.55 ATOM 3432 0 TYR C 50 -8.410 -21.203 -38.844 1.00 26.55
ATOM 3433 N GLU C 51 -7.367 -20.097 -37.194 1. 00 26.64  ATOM 3433 N GLU C 51 -7.367 -20.097 -37.194 1.00 26.64
ATOM 3434 CA GLU C 51 - 8.481 -20.200 -36.282 1. 00 28.92  ATOM 3434 CA GLU C 51-8.481 -20.200 -36.282 1. 00 28.92
ATOM 3435 CB GLU C 51 -8.106 -19.505 -34.979 1. 00  ATOM 3435 CB GLU C 51 -8.106 -19.505 -34.979 1. 00
ATOM 3436 CG GLU C 51 -8.709 -20.148 -33.761 1. 00 37.67  ATOM 3436 CG GLU C 51 -8.709 -20.148 -33.761 1. 00 37.67
ATOM 3437 CD GLU C 51 -8.076 -21.482 -33.451 1. 00 39.22  ATOM 3437 CD GLU C 51 -8.076 -21.482 -33.451 1. 00 39.22
ATOM 3438 0E1 GLU C 51 - 8.833一 22.462 -33.274 1. 00  ATOM 3438 0E1 GLU C 51-8.833 1 22.462 -33.274 1. 00
ATOM 3439 0E2 GLU C 51 -6.825 -21.547 -33.383 1. 00 39.30  ATOM 3439 0E2 GLU C 51 -6.825 -21.547 -33.383 1. 00 39.30
ATOM 3440 C GLU C 51 - 9.764 -19.581 —36.874 1. 00 29.51  ATOM 3440 C GLU C 51-9.764 -19.581 —36.874 1. 00 29.51
ATOM 3441 0 GLU C 51 -10.861 —20.127 -36.716 1. 00 29.62  ATOM 3441 0 GLU C 51 -10.861 —20.127 -36.716 1. 00 29.62
00  00
ATOM 3442 N ALA C 52 -9.620 -18.450 -37.563 1. 00 27.95  ATOM 3442 N ALA C 52 -9.620 -18.450 -37.563 1.00 27.95
ATOM 3443 CA ALA C 52 -10.770 -17.667 -38.003 1. 00 25.35  ATOM 3443 CA ALA C 52 -10.770 -17.667 -38.003 1. 00 25.35
ATOM 3444 CB ALA C 52 -10.385 -16.201 -38.155 1. 00 25.94  ATOM 3444 CB ALA C 52 -10.385 -16.201 -38.155 1. 00 25.94
ATOM 3445 C ALA C 52 -11.345 -18.178 -39.307 .1. 00 25.83  ATOM 3445 C ALA C 52 -11.345 -18.178 -39.307 .1. 00 25.83
ATOM 3446 0 ALA C 52 -12.438 -17.763 -39.711 1. 00 25.67  ATOM 3446 0 ALA C 52 -12.438 -17.763 -39.711 1. 00 25.67
ATOM 3447 N THR C 53 -10.614 -19.069 - 39.972 1. 00 24.06  ATOM 3447 N THR C 53 -10.614 -19.069-39.972 1. 00 24.06
ATOM 3448 CA THR C 53 -11.104 -19.654 -41.215 1. ,00 24.43  ATOM 3448 CA THR C 53 -11.104 -19.654 -41.215 1., 00 24.43
ATOM 3449 CB THR C 53 -10.088 -19.474 -42.348 1. ,00 25.96  ATOM 3449 CB THR C 53 -10.088 -19.474 -42.348 1., 00 25.96
ATOM 3450 0G1 THR G 53 -8.824 -20.026 -41.958 1. ,00 25.27  ATOM 3450 0G1 THR G 53 -8.824 -20.026 -41.958 1., 00 25.27
ATOM 3451 CG2 THR C 53 -9.935 -17.999 -42.681 1. ,00 25.66  ATOM 3451 CG2 THR C 53 -9.935 -17.999 -42.681 1., 00 25.66
ATOM 3452 C THR C 53 -11.469 -21.137 -41.121 1. .00 24.38  ATOM 3452 C THR C 53 -11.469 -21.137 -41.121 1. .00 24.38
ATOM 3453 0 THR C 53 -21.811 -42.140 1, .00 24.55  ATOM 3453 0 THR C 53 -21.811 -42.140 1, .00 24.55
ATOM 3454 N ALA C 54 -11.623 -21.641 -39.904 1. .00 25.34  ATOM 3454 N ALA C 54 -11.623 -21.641 -39.904 1. .00 25.34
ATOM 3455 CA ALA C 54 -12.054 -23.021 - 39.704 1. .00 28.08  ATOM 3455 CA ALA C 54 -12.054 -23.021-39.704 1. .00 28.08
ATOM 3456 CB ALA C 54 -12.046 -23.362 -38.226 1. .00 26.09  ATOM 3456 CB ALA C 54 -12.046 -23.362 -38.226 1. .00 26.09
ATOM 3457 C ALA C 54 -13.432 - 23.297 -40.289 1, .00 30.67  ATOM 3457 C ALA C 54 -13.432-23.297 -40.289 1, .00 30.67
ATOM 3458 0 ALA C 54 -13.745 -24.441 -40.623 1, .00 33.13  ATOM 3458 0 ALA C 54 -13.745 -24.441 -40.623 1, .00 33.13
ATOM 3459 N ASP c 55 -14.259 」22.260 -40.421 1, .00 34.16  ATOM 3459 N ASP c 55 -14.259 `` 22.260 -40.421 1, .00 34.16
ATOM 3460 CA ASP c 55 -15.632 -22.455 -40.893 1, .00 37.05  ATOM 3460 CA ASP c 55 -15.632 -22.455 -40.893 1, .00 37.05
ATOM 3461 CB ASP c 55 -16.629 -21.689 -40.004 1 .00 38.83  ATOM 3461 CB ASP c 55 -16.629 -21.689 -40.004 1 .00 38.83
ATOM 3462 CG ASP G 55 -16.456 - 20.176 -40.077 1 ■ 00 42.63  ATOM 3462 CG ASP G 55 -16.456-20.176 -40.077 1 ■ 00 42.63
ATOM 3463 0D1 ASP C 55 -15.789 -19.672 -41.008 1 ■ 00 44.84  ATOM 3463 0D1 ASP C 55 -15.789 -19.672 -41.008 1 ■ 00 44.84
ATOM 3464 0D2 ASP C 55 -16.998 -19.484 -39.188 1 • 00 44.90  ATOM 3464 0D2 ASP C 55 -16.998 -19.484 -39.188 1 • 00 44.90
ATOM 3465 C ASP C 55 -15.861 -22.092 - 42.358 1 ■ 00 37.94  ATOM 3465 C ASP C 55 -15.861 -22.092-42.358 1 ■ 00 37.94
ATOM 3466 0 ASP C 55 -16.986 -22.176 -42.856 1 .00 38.64  ATOM 3466 0 ASP C 55 -16.986 -22.176 -42.856 1 .00 38.64
ATOM 3467 N LEU c 56 -14.799 -21.699 -43.051 1 .00 38.08 ATOM 3468 CA LEU C 56 -14.892 -21.433 -44.481 1.00 39.66 CATOM 3467 N LEU c 56 -14.799 -21.699 -43.051 1 .00 38.08 ATOM 3468 CA LEU C 56 -14.892 -21.433 -44.481 1.00 39.66 C
ATOM 3469 CB LEU C 56 -13.498 -21.199 -45.059 1.00 39.35 CATOM 3469 CB LEU C 56 -13.498 -21.199 -45.059 1.00 39.35 C
ATOM 3470 CG LEU C 56 —12.953 -19.777 -44.913 1.00 39.55 GATOM 3470 CG LEU C 56 —12.953 -19.777 -44.913 1.00 39.55 G
ATOM 3471 CD1 LEU C 56 -11.463 -19.752 -45.222 1.0041.40 CATOM 3471 CD1 LEU C 56 -11.463 -19.752 -45.222 1.0041.40 C
ATOM 3472 CD2 LEU C 56 -13.716 -18.862 -45.858 1.00 38.34 CATOM 3472 CD2 LEU C 56 -13.716 -18.862 -45.858 1.00 38.34 C
ATOM 3473 C LEU C 56 - 15.567 -22.583 - 45.218 1.00 40.73 CATOM 3473 C LEU C 56-15.567 -22.583-45.218 1.00 40.73 C
ATOM 3474 0 LEU C 56 - 15.451 - 23.735 -44.815 1.00 41.37 0ATOM 3474 0 LEU C 56-15.451-23.735 -44.815 1.00 41.37 0
ATOM 3475 N GLU C 57 -16.277 -22.264 -46.296 1.0043.38 NATOM 3475 N GLU C 57 -16.277 -22.264 -46.296 1.0043.38 N
ATOM 3476 CA 6LU C 57 -16.987 -23.275 -47.080 1.00 45.62 CATOM 3476 CA 6LU C 57 -16.987 -23.275 -47.080 1.00 45.62 C
ATOM 3477 CB GLU C 57 -18.314 -22.715 -47.620 1.00 49.04 CATOM 3477 CB GLU C 57 -18.314 -22.715 -47.620 1.00 49.04 C
ATOM 3478 CG GLU G 57 -19.246 -22.115 -46.567 1.00 53.26 CATOM 3478 CG GLU G 57 -19.246 -22.115 -46.567 1.00 53.26 C
ATOM 3479 CD GLU C 57 -19.761 - 23.143 -45.569 1.00 57.06 CATOM 3479 CD GLU C 57 -19.761-23.143 -45.569 1.00 57.06 C
ATOM 3480 0E1 GLU C 57 -20.104 -24.271 -45.994 1.00 58.50 0ATOM 3480 0E1 GLU C 57 -20.104 -24.271 -45.994 1.00 58.50 0
ATOM 3481 0E2 GLU C 57 -19.823 -22.821 -44.359 1.0058.00 0ATOM 3481 0E2 GLU C 57 -19.823 -22.821 -44.359 1.0058.00 0
ATOM 3482 C GLU C 57 -16.132 -23.715 -48.258 1.00 44.89 CATOM 3482 C GLU C 57 -16.132 -23.715 -48.258 1.00 44.89 C
ATOM 3483 0 GLU C 57 -15.579 -22.883 -48.964 1.00 45.97 0ATOM 3483 0 GLU C 57 -15.579 -22.883 -48.964 1.00 45.97 0
ATOM 3484 N THR C 58 -16.032 -25.019 —48.480 1.00 45.15 NATOM 3484 N THR C 58 -16.032 -25.019 --48.480 1.00 45.15 N
ATOM 3485 CA THR C 58 -15.308 -25.519 -49.643 1.00 45.25 CATOM 3485 CA THR C 58 -15.308 -25.519 -49.643 1.00 45.25 C
ATOM 3486 CB THR C 58 一 14.271 -26.577 - 49.250 1.00 43.45 CATOM 3486 CB THR C 58 1 14.271 -26.577-49.250 1.00 43.45 C
ATOM 3487 0G1 THR C 58 -14.943 -27.776 -48.860 1.00 44.17 0ATOM 3487 0G1 THR C 58 -14.943 -27.776 -48.860 1.00 44.17 0
ATOM 3488 CG2 THR C 58 -13.427 - 26.090 -48.089 1.00 43.45 CATOM 3488 CG2 THR C 58 -13.427-26.090 -48.089 1.00 43.45 C
ATOM 3489 C THR C 58 -16.285 - 26.147 -50.630 1.0045.95 CATOM 3489 C THR C 58 -16.285-26.147 -50.630 1.0045.95 C
ATOM 3490 0 THR C 58 -17.429 -26.436一 50.279 1.00 46.47 0ATOM 3490 0 THR C 58 -17.429 -26.436 One 50.279 1.00 46.47 0
ATOM 3491 N GLU C 59 - 15.834 -26.348 -51.864 1.00 45.64 NATOM 3491 N GLU C 59-15.834 -26.348 -51.864 1.00 45.64 N
ATOM 3492 CA GLU c 59 -16.651 -27.010 -52.873 1.0046.80 CATOM 3492 CA GLU c 59 -16.651 -27.010 -52.873 1.0046.80 C
ATOM 3493 CB GLU c 59 -17.158 -25.998 - 53.900 1.00 48.11 CATOM 3493 CB GLU c 59 -17.158 -25.998-53.900 1.00 48.11 C
ATOM 3494 CG GLU c 59 -16.077 -25.455 - 54.818 1.00 52.65 CATOM 3494 CG GLU c 59 -16.077 -25.455-54.818 1.00 52.65 C
ATOM 3495 CD GLU c 59 -16.497 -24.187 -55.547 1.00 55.22 CATOM 3495 CD GLU c 59 -16.497 -24.187 -55.547 1.00 55.22 C
ATOM 3496 0E1 GLU c 59 -17.335 -23.430 - 55.005 1.00 56.12 0ATOM 3496 0E1 GLU c 59 -17.335 -23.430-55.005 1.00 56.12 0
ATOM 3497 0E2 GLU c 59 -15.987 - 23.949 -56.663 1.00 56.32 0ATOM 3497 0E2 GLU c 59 -15.987-23.949 -56.663 1.00 56.32 0
ATOM 3498 C GLU G 59 -15.850 -28.097 -53.579 1.00 46.35 CATOM 3498 C GLU G 59 -15.850 -28.097 -53.579 1.00 46.35 C
ATOM 3499 0 GLU C 59 一 14.632 -27.991 -53.719 1.0045.49 0ATOM 3499 0 GLU C 59 One 14.632 -27.991 -53.719 1.0045.49 0
ATOM 3500 N LYS C 60 -16.545 - 29.142 -54.018 1.0045.98 NATOM 3500 N LYS C 60 -16.545-29.142 -54.018 1.0045.98 N
ATOM 3501 CA LYS c 60 - 15.912 -30.268 -54.694 1.00 45.84 CATOM 3501 CA LYS c 60-15.912 -30.268 -54.694 1.00 45.84 C
ATOM 3502 CB LYS c 60 -16.828 -31.492 -54.658 1 · 00 44.48 CATOM 3502 CB LYS c 60 -16.828 -31.492 -54.658 1 00 44.48 C
ATOM 3503 CG LYS c 60 -17.202 -31.954一 53.264 1.0044.00 C ATOM 3504 CD LYS C 60 -15.992 - 32.453 - 52.509 1.00 44.67 CATOM 3503 CG LYS c 60 -17.202 -31.954 One 53.264 1.0044.00 C ATOM 3504 CD LYS C 60 -15.992-32.453-52.509 1.00 44.67 C
ATOM 3505 CE LYS C 60 -16.397 -33.313 -51. 326 1.00 44.46 CATOM 3505 CE LYS C 60 -16.397 -33.313 -51. 326 1.00 44.46 C
ATOM 3506 NZ LYS C 60 -15.224 -33.697 -50. 491 1.00 43.55 NATOM 3506 NZ LYS C 60 -15.224 -33.697 -50. 491 1.00 43.55 N
ATOM 3507 C LYS C 60 一 15.613 -29.921 -56. 141 1.00 45.75 CATOM 3507 C LYS C 60 1 15.613 -29.921 -56. 141 1.00 45.75 C
ATOM 3508 0 LYS C 60 -16.514 -29.588 -56. 904 1.00 46.03 0ATOM 3508 0 LYS C 60 -16.514 -29.588 -56. 904 1.00 46.03 0
ATOM 3509 N VAL C 61 -14.344 -29.997 - 56. 513 1.00 45.78 NATOM 3509 N VAL C 61 -14.344 -29.997-56. 513 1.00 45.78 N
ATOM 3510 CA VAL C 61 -13.959 -29.884 -57. 910 1.00 46.58 CATOM 3510 CA VAL C 61 -13.959 -29.884 -57. 910 1.00 46.58 C
ATOM 3511 CB VAL C 61 -13.026 -28.678 - 58. 139 1.00 47.74 CATOM 3511 CB VAL C 61 -13.026 -28.678-58. 139 1.00 47.74 C
ATOM 3512 CG1 VAL C 61 -12.860 -28.423 - 59. 628 1.00 47.93 CATOM 3512 CG1 VAL C 61 -12.860 -28.423-59. 628 1.00 47.93 C
ATOM 3513 CG2 VAL C 61 -13.583 -27.447 -57. 444 1.00 49.67 CATOM 3513 CG2 VAL C 61 -13.583 -27.447 -57. 444 1.00 49.67 C
ATOM 3514 C VAL C 61 -13.217 -58. 295 1.00 46.85 CATOM 3514 C VAL C 61 -13.217 -58. 295 1.00 46.85 C
ATOM 3515 .0 VAL C 61 - 12.555 -31.778 -57. 463 1.00 46.84 0ATOM 3515 .0 VAL C 61-12.555 -31.778 -57. 463 1.00 46.84 0
ATOM 3516 N THR C 62 -13.332 -59. 551 1 · 00 47.43 NATOM 3516 N THR C 62 -13.332 -59. 551 1 00 47.43 N
ATOM 3517 CA THR C 62 -12.575 -32.717 -60. 017 1.00 46.92 CATOM 3517 CA THR C 62 -12.575 -32.717 -60. 017 1.00 46.92 C
ATOM 3518 CB THR C 62 -13.455 -33.675 -60. 839 1.00 47.57 CATOM 3518 CB THR C 62 -13.455 -33.675 -60. 839 1.00 47.57 C
ATOM 3519 061 THR C 62 -13.928 -33.003 - 62. 014 1.00 51.34 0ATOM 3519 061 THR C 62 -13.928 -33.003-62. 014 1.00 51.34 0
ATOM 3520 CG2 THR C 62 -14.643 -34.140 -60. 009 1.00 45.03 CATOM 3520 CG2 THR C 62 -14.643 -34.140 -60. 009 1.00 45.03 C
ATOM 3521 C THR C 62 -11.409 -32.242 - 60. 869 1.00 46.21 CATOM 3521 C THR C 62 -11.409 -32.242-60. 869 1.00 46.21 C
ATOM 3522 0 THR C 62 -11.569 -31 · 371 -61. 729 1.00 45.26 0ATOM 3522 0 THR C 62 -11.569 -31 371 -61. 729 1.00 45.26 0
ATOM 3523 N ILE C 63 -10.235 -32.806 - 60. 607 1.00 44.42 NATOM 3523 N ILE C 63 -10.235 -32.806-60. 607 1.00 44.42 N
ATOM 3524 CA ILE C 63 -9.029 -32.465 -61. 347 1.00 43.58 CATOM 3524 CA ILE C 63 -9.029 -32.465 -61. 347 1.00 43.58 C
ATOM 3525 CB ILE C 63 -8.029 -31.698 -60. 462 1.00 43.67 CATOM 3525 CB ILE C 63 -8.029 -31.698 -60. 462 1.00 43.67 C
ATOM 3526 CG2 ILE C 63 -8.685 -30.448 -59.898 1.00 42.56 CATOM 3526 CG2 ILE C 63 -8.685 -30.448 -59.898 1.00 42.56 C
ATOM 3527 CG1 ILE c 63 -7.561 -32.605 - 59. 323 1.00 44.31 CATOM 3527 CG1 ILE c 63 -7.561 -32.605-59. 323 1.00 44.31 C
ATOM 3528 CD1 ILE c 63 -6.354 -32.092 -58. 576 1 · 00 44.88 CATOM 3528 CD1 ILE c 63 -6.354 -32.092 -58. 576 1 00 44.88 C
ATOM 3529 C ILE c 63 -8.353 -33.746 -61. 813 1.00 42.82 CATOM 3529 C ILE c 63 -8.353 -33.746 -61. 813 1.00 42.82 C
ATOM 3530 0 ILE c 63 -8.648 -34.830 -61. 319 1.00 40.78 0ATOM 3530 0 ILE c 63 -8.648 -34.830 -61. 319 1.00 40.78 0
ATOM 3531 N GLU c 64 -7.441 -33.616 -62. 766 1.00 43.80 NATOM 3531 N GLU c 64 -7.441 -33.616 -62. 766 1.00 43.80 N
ATOM 3532 CA GLU c 64 -6.630 - 34.743 - 63. 184 1.00 44.47 CATOM 3532 CA GLU c 64 -6.630-34.743-63. 184 1.00 44.47 C
ATOM 3533 CB GLU c 64 -6.128 -34.522 - 64. 611 1.00 46.29 CATOM 3533 CB GLU c 64 -6.128 -34.522-64. 611 1.00 46.29 C
ATOM 3534 CG GLU c 64 - 7.062 -35.062 - 65. 674 1.00.47.76 CATOM 3534 CG GLU c 64-7.062 -35.062-65. 674 1.00.47.76 C
ATOM 3535 CD GLU G 64 - 7.133 -36.576 -65. 652 1.00 48.92 CATOM 3535 CD GLU G 64-7.133 -36.576 -65. 652 1.00 48.92 C
ATOM 3536 0E1 GLU G 64 - 8.249 -37.116 -65. 799 1.00 50.69 0ATOM 3536 0E1 GLU G 64-8.249 -37.116 -65. 799 1.00 50.69 0
ATOM 3537 0E2 GLU C 64 -6.073 - 37.226 - 65. 484 1.00 46.66 0ATOM 3537 0E2 GLU C 64 -6.073-37.226-65. 484 1.00 46.66 0
ATOM 3538 C GLU C 64 -5.449 - 34.929 -62. 234 1.00 45.09 CATOM 3538 C GLU C 64 -5.449-34.929 -62. 234 1.00 45.09 C
ATOM 3539 0 GLU C 64 -4.553 -34.086一 62. 163 1.00 43.22 0 ATOM 3540 N GLY C 65 -5.459 -36.040 -61.504 1.00 44.88 NATOM 3539 0 GLU C 64 -4.553 -34.086 1 62. 163 1.00 43.22 0 ATOM 3540 N GLY C 65 -5.459 -36.040 -61.504 1.00 44.88 N
ATOM 3541 CA GLY C 65 -4.355 -36.355 -60.623 1.00 45.52 CATOM 3541 CA GLY C 65 -4.355 -36.355 -60.623 1.00 45.52 C
ATOM 3542 C GLY C 65 -3.268一 37.163 -61.311 1.00 47.69 CATOM 3542 C GLY C 65 -3.268 1 37.163 -61.311 1.00 47.69 C
ATOM 3543 0 GLY C 65 - 3.373 -37.509 -62.491 1.0046.81 0ATOM 3543 0 GLY C 65-3.373 -37.509 -62.491 1.0046.81 0
ATOM 3544 N TRP C 66 -2.218 -37.476 -60.561 1.00 49.43 NATOM 3544 N TRP C 66 -2.218 -37.476 -60.561 1.00 49.43 N
ATOM 3545 CA TRP C 66 -1.061 - 38.152 -61.120 1.00 51.09 CATOM 3545 CA TRP C 66 -1.061-38.152 -61.120 1.00 51.09 C
ATOM 3546 CB TRP C 66 0.029 -38.295 -60.058 1.0053.22 CATOM 3546 CB TRP C 66 0.029 -38.295 -60.058 1.0053.22 C
ATOM 3547 CG TRP C 66 -0.237 -39.394 -59.083 1.00 54.46 CATOM 3547 CG TRP C 66 -0.237 -39.394 -59.083 1.00 54.46 C
ATOM 3548 CD2 TRP C 66 0.252一 40.737 -59.155 1.00 55.14 CATOM 3548 CD2 TRP C 66 0.252 1 40.737 -59.155 1.00 55.14 C
ATOM 3549 CE2 TRP C 66 -0.249一 41.425一 58.032 1.0055.25 CATOM 3549 CE2 TRP C 66 -0.249 1 41.425 1 58.032 1.0055.25 C
ATOM 3550 CE3 TRP C 66 1.065 -41.424 -60.059 1.00 56.13 CATOM 3550 CE3 TRP C 66 1.065 -41.424 -60.059 1.00 56.13 C
ATOM 3551 CD1 TRP C 66 -0.993 - 39.322 -57.952 1.00 54.87 CATOM 3551 CD1 TRP C 66 -0.993-39.322 -57.952 1.00 54.87 C
ATOM 3552 NE1 TRP C 66 - 1.006 -40.540 -57.313 1.00 55.33 NATOM 3552 NE1 TRP C 66-1.006 -40.540 -57.313 1.00 55.33 N
ATOM 3553 CZ2 TRP C 66 0.035 -42.767 -57.789 1.00 56.58 CATOM 3553 CZ2 TRP C 66 0.035 -42.767 -57.789 1.00 56.58 C
ATOM 3554 CZ3 TRP C 66 1.348 -42.756 -59.817 1.00 57.78 CATOM 3554 CZ3 TRP C 66 1.348 -42.756 -59.817 1.00 57.78 C
ATOM 3555 CH2 TRP C 66 0.834 -43.413 -58.691 1.00 57.43 CATOM 3555 CH2 TRP C 66 0.834 -43.413 -58.691 1.00 57.43 C
ATOM 3556 C TRP C 66 -1.446 -39.527 -61.641 1.00 51.31 CATOM 3556 C TRP C 66 -1.446 -39.527 -61.641 1.00 51.31 C
ATOM 3557 0 TRP C 66 -0.711 -40.125 - 62.423 1.00 53.00 0ATOM 3557 0 TRP C 66 -0.711 -40.125-62.423 1.00 53.00 0
ATOM 3558 N ASN c 67 -2.595 -40.027 -61.201 1.00 50.44 NATOM 3558 N ASN c 67 -2.595 -40.027 -61.201 1.00 50.44 N
ATOM 3559 CA ASN c 67 - 3.047 -41.353 -61.599 1.00 50.48 CATOM 3559 CA ASN c 67-3.047 -41.353 -61.599 1.00 50.48 C
ATOM 3560 CB ASN c 67 -2.821 - 42.343 -60.452 1.00 53.11 CATOM 3560 CB ASN c 67 -2.821-42.343 -60.452 1.00 53.11 C
ATOM 3561 CG ASN c 67 -2.967 -43.790 -60.889 1.00 55.38 CATOM 3561 CG ASN c 67 -2.967 -43.790 -60.889 1.00 55.38 C
ATOM 3562 0D1 ASN c 67 -3.111 —44.083 —62.079 1.00 55.12 0ATOM 3562 0D1 ASN c 67 -3.111 --44.083 --62.079 1.00 55.12 0
ATOM 3563 ND2 ASN c 67 -2.929 -44.705 -59.925 1.00 56.01 NATOM 3563 ND2 ASN c 67 -2.929 -44.705 -59.925 1.00 56.01 N
ATOM 3564 C ASN c 67 -4.526 -41.349 -61.998 1.0049.39 CATOM 3564 C ASN c 67 -4.526 -41.349 -61.998 1.0049.39 C
ATOM 3565 0 ASN c 67 -5.284 -42.248 -61.626 1■ 0048.36 0ATOM 3565 0 ASN c 67 -5.284 -42.248 -61.626 1 ■ 0048.36 0
ATOM 3566 N GLY c 68 -4.930 -40.334—62.758 1.0047.94 NATOM 3566 N GLY c 68 -4.930 -40.334—62.758 1.0047.94 N
ATOM 3567 CA GLY c 68 -6.317 -40.228 -63.172 1.00 44.99 CATOM 3567 CA GLY c 68 -6.317 -40.228 -63.172 1.00 44.99 C
ATOM 3568 C GLY c 68 -7.101 -39.213 -62.362 1.00 43.86 CATOM 3568 C GLY c 68 -7.101 -39.213 -62.362 1.00 43.86 C
ATO 3569 0 GLY c 68 -6.569 -38.610 -61.434 1.0043.49 0ATO 3569 0 GLY c 68 -6.569 -38.610 -61.434 1.0043.49 0
ATOM 3570 N PRO c 69 -8.385 -39.012—62.687 1.00 42.62 NATOM 3570 N PRO c 69 -8.385 -39.012—62.687 1.00 42.62 N
ATOM 3571 CD PRO c 69 -9.117 -39.733 -63.742 1.00 41.58 CATOM 3571 CD PRO c 69 -9.117 -39.733 -63.742 1.00 41.58 C
ATOM 3572 CA PRO c 69 -9.226 - 38.003 -62.035 1.0041.95 CATOM 3572 CA PRO c 69 -9.226-38.003 -62.035 1.0041.95 C
ATOM 3573 CB PRO c 69 - 10.577 -38.159 -62.728 1.0040.98 CATOM 3573 CB PRO c 69-10.577 -38.159 -62.728 1.0040.98 C
ATOM 3574 CG PRO c 69 - 10.261 -38.819 -64.025 1.0042.29 CATOM 3574 CG PRO c 69-10.261 -38.819 -64.025 1.0042.29 C
ATOM 3575 C PRO c 69 一 9, 340 -38.200 -60.525 1.0041.96 C ATOM 3576 0 PRO C 69 -9.437 - 39.328 -60.038 1.0043.16 0ATOM 3575 C PRO c 69 I 9, 340 -38.200 -60.525 1.0041.96 C ATOM 3576 0 PRO C 69 -9.437-39.328 -60.038 1.0043.16 0
ATOM 3577 N VAL C 70 -9.327 37.092 -59.791 1. 00 40.23 NATOM 3577 N VAL C 70 -9.327 37.092 -59.791 1. 00 40.23 N
ATOM 3578 CA VAL C 70 -9.605 - 37.107 -58.360 1. 00 40.30 CATOM 3578 CA VAL C 70 -9.605-37.107 -58.360 1.00 40.30 C
ATOM 3579 CB VAL C 70 -8.304 -36.928 -57.538 1. 00 41.29 CATOM 3579 CB VAL C 70 -8.304 -36.928 -57.538 1. 00 41.29 C
ATOM 3580 C61 VAL C 70 -8.630 -36.821 - 56.063 1. 00 42.28 CATOM 3580 C61 VAL C 70 -8.630 -36.821-56.063 1. 00 42.28 C
ATOM 3581 CG2 VAL C 70 -7.378 -38.098 - 57.772 1. 00 42.51 CATOM 3581 CG2 VAL C 70 -7.378 -38.098-57.772 1. 00 42.51 C
ATOM 3582 C VAL C 70 -10.565 -35.975 - 58.007 1. 00 39.37 GATOM 3582 C VAL C 70 -10.565 -35.975-58.007 1. 00 39.37 G
ATOM 3583 0 VAL C 70 -10.478 -34.883 -58.562 1. 00 39.92 0ATOM 3583 0 VAL C 70 -10.478 -34.883 -58.562 1. 00 39.92 0
ATOM 3584 N 6LU C 71 - T11.483 -36.231 -57.083 1. 00 39.63 NATOM 3584 N 6LU C 71-T11.483 -36.231 -57.083 1. 00 39.63 N
ATOM 3585 CA 6LU C 71 -12.3o t18 -35.157 -56.556 1. 00 40.01 CATOM 3585 CA 6LU C 71 -12.3o t18 -35.157 -56.556 1.00 40.01 C
ATOM 3586 CB 6LU C 71 -13.664 - 35.707 -56.091 1. 00 40.54 CATOM 3586 CB 6LU C 71 -13.664-35.707 -56.091 1.00 40.54 C
ATOM 3587 ,CG GLU C 71 -14.636 -34.621 - 55.667 1. 00 45.34 C o ATOM 3587, CG GLU C 71 -14.636 -34.621-55.667 1.00 45.34 Co
ATOM 3588 CD 6LU C 71 -16.021 -35.149 -55.338 1. 00 46.96 . C ATOM 3588 CD 6LU C 71 -16.021 -35.149 -55.338 1. 00 46.96. C
ATOM 3589 0E1 GLU C 71 -16.936 -34.991 -56.179 1. 00 47.72 0ATOM 3589 0E1 GLU C 71 -16.936 -34.991 -56.179 1.00 47.72 0
ATOM 3590 0E2 GLU C 71 -16.194 -35.715 -54.237 1. 00 48.08 0ATOM 3590 0E2 GLU C 71 -16.194 -35.715 -54.237 1. 00 48.08 0
ATOM 3591 C GLU C 71 -34.476 - 55.389 1. 00 39.33 GATOM 3591 C GLU C 71 -34.476-55.389 1. 00 39.33 G
ATOM 3592 0 GLU C 71 -11.142 - 35.137 -54.463 1. 00 39.71 0ATOM 3592 0 GLU C 71 -11.142-35.137 -54.463 1. 00 39.71 0
ATOM 3593 N ILE C 72 -11 · 500 -33.154 -55.438 1. ,00 39.21 NATOM 3593 N ILE C 72 -11500 -33.154 -55.438 1., 00 39.21 N
ATOM 3594 CA ILE c 72 -10.788 -32.421 -54.396 1. .00 38.58 CATOM 3594 CA ILE c 72 -10.788 -32.421 -54.396 1. .00 38.58 C
ATOM 3595 CB ILE c 72 -9.505 -31.770 -54.935 1. 00 38.20 CATOM 3595 CB ILE c 72 -9.505 -31.770 -54.935 1. 00 38.20 C
ATOM 3596 CG2 ILE c 72 -8.570 -32.833 - 55.503 1. ,00 36.20 CATOM 3596 CG2 ILE c 72 -8.570 -32.833-55.503 1., 00 36.20 C
ATOM 3597 CG1 ILE c 72 -9.872 -30.743 - 56.009 1. ,00 37.32 CATOM 3597 CG1 ILE c 72 -9.872 -30.743-56.009 1., 00 37.32 C
ATOM 3598 CD1 ILE c 72 -8.890 -29.605 -56.134 1. .00 36.83 CATOM 3598 CD1 ILE c 72 -8.890 -29.605 -56.134 1. .00 36.83 C
ATOM 3599 C ILE c 72 -11.656 -31.314 -53.824 1. .00 40.08 CATOM 3599 C ILE c 72 -11.656 -31.314 -53.824 1. .00 40.08 C
ATOM 3600 0 ILE c 72 -12.676 -30.934 -54.410 1. .00 38.59 0ATOM 3600 0 ILE c 72 -12.676 -30.934 -54.410 1. .00 38.59 0
ATOM 3601 N ASP c 73 -30.789 - 52.679 1, .00 40.56 NATOM 3601 N ASP c 73 -30.789-52.679 1, .00 40.56 N
ATOM 3602 CA ASP c 73 -11.939 -29.676 -52.064 1, .00 41.81 CATOM 3602 CA ASP c 73 -11.939 -29.676 -52.064 1, .00 41.81 C
ATOM 3603 CB ASP c 73 -12.072 - 29.907 - 50.559 1, .00 43.07 CATOM 3603 CB ASP c 73 -12.072-29.907-50.559 1, .00 43.07 C
ATOM 3604 CG ASP c 73 - 12.943 -50.230 1, .00 43.69 CATOM 3604 CG ASP c 73-12.943 -50.230 1, .00 43.69 C
ATO 3605 0D1 ASP c 73 -12.377 -32.187 -49.965 1, .00 46.41 0ATO 3605 0D1 ASP c 73 -12.377 -32.187 -49.965 1, .00 46.41 0
ATOM 3606 0D2 ASP c 73 -14.188 -30.975 -50.234 1, .00 42.84 0ATOM 3606 0D2 ASP c 73 -14.188 -30.975 -50.234 1, .00 42.84 0
ATOM 3607 C ASP c 73 -11.213 -28.369 -52.333 1 .00 41.96 CATOM 3607 C ASP c 73 -11.213 -28.369 -52.333 1 .00 41.96 C
ATOM 3608 0 ASP c 73 -9.983 -28.317 -52.325 1 .00 41.30 0ATOM 3608 0 ASP c 73 -9.983 -28.317 -52.325 1 .00 41.30 0
ATOM 3609 N GLN c 74 -11.986 -27.315 -52.577 1 .00 42.31 NATOM 3609 N GLN c 74 -11.986 -27.315 -52.577 1 .00 42.31 N
ATOM 3610 CA GLN c 74 -11■ 428 -26.018 -52.938 1 • 00 42.85 CATOM 3610 CA GLN c 74 -11 ■ 428 -26.018 -52.938 1 • 00 42.85 C
ATOM 3611 CB GLN c 74 -11.460 -25.826一 54.454 1 ,00 42.16 C ATOM 3612 CG GLN C 74 -10.547 - 26.766 -55.224 1.00 43.95 CATOM 3611 CB GLN c 74 -11.460 -25.826 1 54.454 1, 00 42.16 C ATOM 3612 CG GLN C 74 -10.547-26.766 -55.224 1.00 43.95 C
ATOM 3613 CD GLN C 74 - 9.090 -26.332 -55.197 1. 00 43.96 CATOM 3613 CD GLN C 74-9.090 -26.332 -55.197 1. 00 43.96 C
ATOM 3614 0E1 GLN C 74 -8.696 - 25.394 -55.897 1. 00 42.88 0ATOM 3614 0E1 GLN C 74 -8.696-25.394 -55.897 1. 00 42.88 0
ATOM 3615 NE2 GLN C 74 -8.280 -27.016 -54.390 1. 00 42.88 NATOM 3615 NE2 GLN C 74 -8.280 -27.016 -54.390 1. 00 42.88 N
ATOM 3616 C GLN G 74 -12.194 -24.886 -52.287 1. 00 43.49 CATOM 3616 C GLN G 74 -12.194 -24.886 -52.287 1. 00 43.49 C
ATOM 3617 0 GLN C 74 -13.419 -24.914 -52.218 1. 00 45.63 0ATOM 3617 0 GLN C 74 -13.419 -24.914 -52.218 1. 00 45.63 0
ATOM 3618 N ILE C 75 -11.463 -23.885 -51. 816 1. 00 43.98 NATOM 3618 N ILE C 75 -11.463 -23.885 -51. 816 1. 00 43.98 N
ATOM 3619 CA ILE C 75 -12.057 -22.612 -51. 447 1. 00 46.17 CATOM 3619 CA ILE C 75 -12.057 -22.612 -51. 447 1. 00 46.17 C
ATOM 3620 CB ILE C 75 -11.382 -22.048 -50.183 1. 00 47.73 CATOM 3620 CB ILE C 75 -11.382 -22.048 -50.183 1.00 47.73 C
ATOM 3621 C62 ILE C 75 -12.000 -20.716 -49.800 1. 00 51.04 CATOM 3621 C62 ILE C 75 -12.000 -20.716 -49.800 1.00 51.04 C
ATOM 3622 CG1 ILE C 75 -11.560 -23.031 - 49. 028 1. 00 50.02 CATOM 3622 CG1 ILE C 75 -11.560 -23.031-49. 028 1. 00 50.02 C
ATOM 3623 , CD1 ILE C 75 -11.132 -22.471 -47. 692 1. 00 52.41 CATOM 3623, CD1 ILE C 75 -11.132 -22.471 -47. 692 1. 00 52.41 C
ATOM 3624 C ILE C 75 -11.870 -21.630 -52. 606 1. 00 46.61 CATOM 3624 C ILE C 75 -11.870 -21.630 -52. 606 1. 00 46.61 C
ATOM 3625 0 ILE C 75 -11.040 -21.850 -53. 488 1. 00 46.81 0ATOM 3625 0 ILE C 75 -11.040 -21.850 -53. 488 1. 00 46.81 0
ATOM 3626 N LYS C 76 -12.650 -20.556 -52. 615 1. ,00 47.08 NATOM 3626 N LYS C 76 -12.650 -20.556 -52. 615 1., 00 47.08 N
ATOM 3627 CA LYS C 76 - 12.419 -19.467 -53. 558 1. ,00 47.30 CATOM 3627 CA LYS C 76-12.419 -19.467 -53. 558 1., 00 47.30 C
ATOM 3628 CB LYS C 76 -13.754 -18.949 -54. 098 1. .00 50.05 CATOM 3628 CB LYS C 76 -13.754 -18.949 -54. 098 1. .00 50.05 C
ATOM 3629 CG LYS C 76 -14.622 -20.005 -54. 783 1. .00 51.14 CATOM 3629 CG LYS C 76 -14.622 -20.005 -54. 783 1. .00 51.14 C
ATOM 3630 CD LYS C 76 -14.126 -20.301 -56. 196 1. .00 52.67 CATOM 3630 CD LYS C 76 -14.126 -20.301 -56. 196 1. .00 52.67 C
ATOM 3631 CE LYS C 76 - 15.221 -20.932 -57. 053 1. .00 55.06 CATOM 3631 CE LYS C 76-15.221 -20.932 -57. 053 1. .00 55.06 C
ATOM 3632 NZ LYS C 76 -14.773 -21.222 -58. 455 1. ,00 52.51 NATOM 3632 NZ LYS C 76 -14.773 -21.222 -58. 455 1., 00 52.51 N
ATOM 3633 C LYS c .76 -11.675 - 18.334 -52. 847 1. ,00 46.47 CATOM 3633 C LYS c .76 -11.675-18.334 -52. 847 1., 00 46.47 C
ATOM 3634 0 LYS c 76 -12.293 -17.490 -52. 195 1, .00 46.57 0ATOM 3634 0 LYS c 76 -12.293 -17.490 -52. 195 1, .00 46.57 0
ATOM 3635 N GLY c 77 一 10.351 -18.320 -52. 977 1. .00 44.29 NATOM 3635 N GLY c 77 1 10.351 -18.320 -52. 977 1. .00 44.29 N
ATOM 3636 CA GLY c 77 -9.549 -17.303 - 52. 320 1. .00 42.25 CATOM 3636 CA GLY c 77 -9.549 -17.303-52. 320 1. .00 42.25 C
ATOM 3637 C GLY c 77 -9.931 -15.877 -52. 680 1. .00 41.71 CATOM 3637 C GLY c 77 -9.931 -15.877 -52. 680 1. .00 41.71 C
ATOM 3638 0 GLY c 77 - 9.976 -15.004 - 51. 811 1, .00 41.17 0ATOM 3638 0 GLY c 77-9.976 -15.004-51. 811 1, .00 41.17 0
ATOM 3639 N LYS c 78 -10.217 -15.641 -53. 956 1, .00 41.34 NATOM 3639 N LYS c 78 -10.217 -15.641 -53. 956 1, .00 41.34 N
ATOM 3640 CA LYS c 78 -10.558 -14.305 -54. 442 1, .00 41.48 CATOM 3640 CA LYS c 78 -10.558 -14.305 -54. 442 1, .00 41.48 C
ATO 3641 CB LYS c 78 -10.819 -14.343 -55. 949 1, .00 42.69 CATO 3641 CB LYS c 78 -10.819 -14.343 -55. 949 1, .00 42.69 C
ATOM 3642 CG LYS c 78 -9.581 -14.616 -56. 782 1 .00 46.30 CATOM 3642 CG LYS c 78 -9.581 -14.616 -56. 782 1 .00 46.30 C
ATOM 3643 CD LYS c 78 -9.855 -15.692 -57. 821 1 .00 49.98 CATOM 3643 CD LYS c 78 -9.855 -15.692 -57. 821 1 .00 49.98 C
ATOM 3644 CE LYS c 78 -10.895 -15.236 -58. 827 1 .00 50.46 CATOM 3644 CE LYS c 78 -10.895 -15.236 -58. 827 1 .00 50.46 C
ATOM 3645 NZ LYS c 78 -10.313 - 14.267 -59. 799 1 • 00 52.37 NATOM 3645 NZ LYS c 78 -10.313-14.267 -59. 799 1 • 00 52.37 N
ATOM 3646 C LYS c 78 -11.773 -13.704 -53. 738 1 • 00 40.46 CATOM 3646 C LYS c 78 -11.773 -13.704 -53. 738 1 • 00 40.46 C
ATOM 3647 0 LYS c 78 -11.931 -12.479 -53. 695 1 .00 39.00 0 ATOM 3648 N LYS C 79 - 12.629 -14.564 -53.194 1.00 37.88 NATOM 3647 0 LYS c 78 -11.931 -12.479 -53. 695 1 .00 39.00 0 ATOM 3648 N LYS C 79-12.629 -14.564 -53.194 1.00 37.88 N
ATOM 3649 CA LYS C 79 -13.840 "14.104 -52.531 1. 00 38.68 CATOM 3649 CA LYS C 79 -13.840 "14.104 -52.531 1. 00 38.68 C
ATOM 3650 CB LYS C 79 -14.930 -15.173 -52.621 1. 00 41.38 CATOM 3650 CB LYS C 79 -14.930 -15.173 -52.621 1.00 41.38 C
ATOM 3651 CG LYS C 79 -15.379 -15.463 -54.046 1. 00 45.34 CATOM 3651 CG LYS C 79 -15.379 -15.463 -54.046 1. 00 45.34 C
ATOM 3652 CD LYS C 79 -16.526 -16.462 -54.089 1. 00 48.58 CATOM 3652 CD LYS C 79 -16.526 -16.462 -54.089 1. 00 48.58 C
ATOM 3653 CE LYS C 79 - 17.874一 15.761 - 54.091 1. 00 51.03 CATOM 3653 CE LYS C 79-17.874 1 15.761-54.091 1.00 51.03 C
ATOM 3654 NZ LYS C 79 -18.010一 14.842 -55.254 1. 00 53.69 NATOM 3654 NZ LYS C 79 -18.010 One 14.842 -55.254 1. 00 53.69 N
ATOM 3655 C LYS C 79 -13.575 -13.743 - 51.071 1. 00 37.19 CATOM 3655 C LYS C 79 -13.575 -13.743-51.071 1. 00 37.19 C
ATOM, 3656 0 LYS C 79 -14.508 -13.494 -50.301 1. 00 36.68 0ATOM, 3656 0 LYS C 79 -14.508 -13.494 -50.301 1.00 36.68 0
ATOM 3657 N ILE C 80 -12.298 -13.714 -50.696 1. 00 33.68 NATOM 3657 N ILE C 80 -12.298 -13.714 -50.696 1. 00 33.68 N
ATOM 3658 CA ILE C 80 - 11.900 - 13.224 -49.384 1. 00 30.49 CATOM 3658 CA ILE C 80-11.900-13.224 -49.384 1. 00 30.49 C
ATOM 3659 CB ILE C 80 -11.039 -14.278 48.628 1. 00 30.39 . CATOM 3659 CB ILE C 80 -11.039 -14.278 48.628 1. 00 30.39. C
ATOM 3660 CG2 ILE C 80 -10.601 -13.735 -47.279 1. 00 26.09 . CATOM 3660 CG2 ILE C 80 -10.601 -13.735 -47.279 1.00 26.09 .C
ATOM 3661 C61 ILE C 80 -11.845 -15.564 -48.426 1. 00 30.71 CATOM 3661 C61 ILE C 80 -11.845 -15.564 -48.426 1. 00 30.71 C
ATOM 3662 CD1 ILE C 80 -11.125 -16.616 - 47.595 1. 00 28.69 CATOM 3662 CD1 ILE C 80 -11.125 -16.616-47.595 1. 00 28.69 C
ATOM 3663 C ILE C 80 -11.098 -11.932 -49.533 1. 00 29.51 CATOM 3663 C ILE C 80 -11.098 -11.932 -49.533 1. 00 29.51 C
ATOM 3664 0 ILE C 80 -10.199 - 11.850 -50.376 1. 00 30.92 0ATOM 3664 0 ILE C 80 -10.199-11.850 -50.376 1. 00 30.92 0
ATOM 3665 N THR C 81 -11.429 -10.929 -48.718 1. 00 27.34 NATOM 3665 N THR C 81 -11.429 -10.929 -48.718 1. 00 27.34 N
ATOM 3666 CA THR C 81 -10.671 -9.679 -48.669 1. ,00 24.20 CATOM 3666 CA THR C 81 -10.671 -9.679 -48.669 1., 00 24.20 C
ATOM 3667 CB THR C 81 -11.583 -8.439 -48.830 1. ,00 24.63 CATOM 3667 CB THR C 81 -11.583 -8.439 -48.830 1., 00 24.63 C
ATOM 3668 0G1 THR C 81 - 12.367 -8.549 - 50.024 1. ,00 27.93 0ATOM 3668 0G1 THR C 81-12.367 -8.549-50.024 1., 00 27.93 0
ATOM 3669 CG2 THR C 81 -10.740 - 7.172 -48.898 1. ,00 22.31 CATOM 3669 CG2 THR C 81 -10.740-7.172 -48.898 1., 00 22.31 C
ATOM 3670 C THR C 81 -9.970 -9.542 -47.316 1. .00 25.25 CATOM 3670 C THR C 81 -9.970 -9.542 -47.316 1. .00 25.25 C
ATOM 3671 0 THR C 81 -10.602 -9.679 -46.264 1. .00 24.15 0ATOM 3671 0 THR C 81 -10.602 -9.679 -46.264 1. .00 24.15 0
ATOM 3672 N VAL c 82 -8.670 -9.254 -47.338 1. .00 23.63 NATOM 3672 N VAL c 82 -8.670 -9.254 -47.338 1. .00 23.63 N
ATOM 3673 CA VAL c 82 - 7.989 -8.834 -46.125 1. .00 23.81 CATOM 3673 CA VAL c 82-7.989 -8.834 -46.125 1. .00 23.81 C
ATOM 3674 CB VAL c 82 -6.527 -9.259 - 46.107 1, .00 25.32 CATOM 3674 CB VAL c 82 -6.527 -9.259-46.107 1, .00 25.32 C
ATOM 3675 CG1 VAL c 82 -5.972 -9.079 - 44.701 1, .00 25.02 CATOM 3675 CG1 VAL c 82 -5.972 -9.079-44.701 1, .00 25.02 C
ATOM 3676 CG2 VAL c 82 - 6.391 -10.678 -46.593 1, .00 28.27 CATOM 3676 CG2 VAL c 82-6.391 -10.678 -46.593 1, .00 28.27 C
ATOM 3677 C VAL c 82 -8.018 -7.314 - 46.035 1, .00 23.89 CATOM 3677 C VAL c 82 -8.018 -7.314-46.035 1, .00 23.89 C
ATOM 3678 0 VAL c 82 -7.792 - 6.617 -47.029 1 .00 23.74 0ATOM 3678 0 VAL c 82 -7.792-6.617 -47.029 1 .00 23.74 0
ATOM 3679 N VAL c 83 -8.287 -6.808 - 44.836 1 .00 23.90 NATOM 3679 N VAL c 83 -8.287 -6.808-44.836 1 .00 23.90 N
ATOM 3680 CA VAL c 83 -8.537 -5.384 - 44.633 1 .00 20.61 CATOM 3680 CA VAL c 83 -8.537 -5.384-44.633 1 .00 20.61 C
ATOM 3681 CB VAL c 83 -10.019 -5.136 -44.289 1 .00 22.60 CATOM 3681 CB VAL c 83 -10.019 -5.136 -44.289 1 .00 22.60 C
ATOM 3682 C61 VAL c 83 -10.246 -3.663 -43.958 1 .00 20.56 CATOM 3682 C61 VAL c 83 -10.246 -3.663 -43.958 1 .00 20.56 C
ATOM 3683 CG2 VAL c 83 -10.895 -5.563 -45.461 1 .00 18.54 G ATOM 3684 C VAL C 83 - 7.663 -4.861 -43.506 1.00 20.82 CATOM 3683 CG2 VAL c 83 -10.895 -5.563 -45.461 1 .00 18.54 G ATOM 3684 C VAL C 83-7.663 -4.861 -43.506 1.00 20.82 C
ATOM 3685 0 VAL C 83 -8.078 - 4.812 -42.353 1.00 22.46 0ATOM 3685 0 VAL C 83 -8.078-4.812 -42.353 1.00 22.46 0
ATOM 3686 N PRO C 84 - 6.422 - 4.479 -43.831 1 · 00 20.66 NATOM 3686 N PRO C 84-6.422-4.479 -43.831 1 00 20.66 N
ATOM 3687 CD PRO C 84 -5.780 - 4.609 - 45.157 1.00 18.75 CATOM 3687 CD PRO C 84 -5.780-4.609-45.157 1.00 18.75 C
ATOM 3688 CA PRO C 84 -5.528 -3.891 -42.836 1.00 19.93 CATOM 3688 CA PRO C 84 -5.528 -3.891 -42.836 1.00 19.93 C
ATOM 3689 CB PRO C 84 -4.162 -3.941 -43.513 1.00 20.97 CATOM 3689 CB PRO C 84 -4.162 -3.941 -43.513 1.00 20.97 C
ATOM 3690 C6 PRO C 84 - 4.482 - 3.876 -44.994 1.00 19.74 CATOM 3690 C6 PRO C 84-4.482-3.876 -44.994 1.00 19.74 C
ATOM 3691 C PRO C 84 -5.951 -2.462 -42.543 1.00 21.86 CATOM 3691 C PRO C 84 -5.951 -2.462 -42.543 1.00 21.86 C
ATOM 3692 0 PRO C 84 -6.254 - 1.699 -43.462 1.00 20.40 0 ATOM 3692 0 PRO C 84 -6.254-1.699 -43.462 1.00 20.40 0
I I
ATOM 3693 N ILE C 85 -5.966 -2.104 -41.263 1.00 21.99 NATOM 3693 N ILE C 85 -5.966 -2.104 -41.263 1.00 21.99 N
ATOM 3694 GA ILE C 85 -6.218 -0.734 -40.860 1.00 21.26 CATOM 3694 GA ILE C 85 -6.218 -0.734 -40.860 1.00 21.26 C
ATOM 3695 CB ILE C 85 -6.966 一 0.693 -39.514 1.00 21.02 ノ GATOM 3695 CB ILE C 85 -6.966 1 0.693 -39.514 1.00 21.02
ATOM 3696 CG2 ILE C 85 - 7.105 0.738 -39.036 1.00 15.87 CATOM 3696 CG2 ILE C 85-7.105 0.738 -39.036 1.00 15.87 C
ATOM 3697 CG1 ILE C 85 -8.344 -1.336 -39.681 1.00 20.34 CATOM 3697 CG1 ILE C 85 -8.344 -1.336 -39.681 1.00 20.34 C
ATOM 3698 CD1 ILE C 85 - 9.212 -1.277 -38.437 1.00 26.00 CATOM 3698 CD1 ILE C 85-9.212 -1.277 -38.437 1.00 26.00 C
ATOM 3699 C ILE C 85 -4.904 0.035 -40.752 1.0020.90 CATOM 3699 C ILE C 85 -4.904 0.035 -40.752 1.0020.90 C
ATOM 3700 0 ILE C 85 -4.003 - 0.351 -40.020 1■ 00 20.64 0ATOM 3700 0 ILE C 85 -4.003-0.351 -40.020 1 ■ 00 20.64 0
ATOM 3701 N LEU C 86 -4.810 1.133 -41.482 1.00 21.14 NATOM 3701 N LEU C 86 -4.810 1.133 -41.482 1.00 21.14 N
ATOM 3702 CA LEU C 86 - 3.520 1.697 -41.816 1.0024.95 CATOM 3702 CA LEU C 86-3.520 1.697 -41.816 1.0024.95 C
ATOM 3703 CB LEU C 86 -3.666 2.866 -42.787 1.00 25.07 CATOM 3703 CB LEU C 86 -3.666 2.866 -42.787 1.00 25.07 C
ATOM 3704 CG LEU C 86 - 3.400 2.370 -44.205 1.00 22.90 CATOM 3704 CG LEU C 86-3.400 2.370 -44.205 1.00 22.90 C
ATOM 3705 CD1 LEU C 86 -3.579 3.490 -45.193 1.0022.96 CATOM 3705 CD1 LEU C 86 -3.579 3.490 -45.193 1.0022.96 C
ATOM 3706 CD2 LEU C 86 1.796 -44.266 1.00 21.80 CATOM 3706 CD2 LEU C 86 1.796 -44.266 1.00 21.80 C
ATOM 3707 C LEU C 86 - 2.618 2.115 -40.682 1.00 27.31 GATOM 3707 C LEU C 86-2.618 2.115 -40.682 1.00 27.31 G
ATOM 3708 0 LEU C 86 -3.055 2.526 - 39.602 1.00 26.21 0ATOM 3708 0 LEU C 86 -3.055 2.526-39.602 1.00 26.21 0
ATOM 3709 N AR6 C 87 - 1.334 2.060 -41.016 1.00 29.28 NATOM 3709 N AR6 C 87-1.334 2.060 -41.016 1.00 29.28 N
ATOM 3710 CA ARG C 87 - 0· 267 1.672 -40.124 1 · 00 29.03 CATOM 3710 CA ARG C 87-0 267 1.672 -40.124 1 00 29.03 C
ATOM 3711 CB ARG c 87 - 0.151 2.668 -38.981 1.0031.94 CATOM 3711 CB ARG c 87-0.151 2.668 -38.981 1.0031.94 C
ATOM 3712 CG ARG c 87 0.506 3.960 -39.453 1.00 33.11 CATOM 3712 CG ARG c 87 0.506 3.960 -39.453 1.00 33.11 C
ATOM 3713 CD ARG c 87 1.273 4.626 -38.337 1.00 31.52 CATOM 3713 CD ARG c 87 1.273 4.626 -38.337 1.00 31.52 C
ATOM 3714 NE ARG c 87 2.700 4.642 -38.601 1.0024.59 NATOM 3714 NE ARG c 87 2.700 4.642 -38.601 1.0024.59 N
ATOM 3715 CZ ARG c 87 3.625 4.728 -37.654 1.00 28.52 CATOM 3715 CZ ARG c 87 3.625 4.728 -37.654 1.00 28.52 C
ATOM 3716 NH1 ARG c 87 3.270 4.795 -36.376 1.00 25.54 NATOM 3716 NH1 ARG c 87 3.270 4.795 -36.376 1.00 25.54 N
ATOM 3717 NH2 ARG c 87 4.906 4.779 - 37.990 1.0030.55 NATOM 3717 NH2 ARG c 87 4.906 4.779-37.990 1.0030.55 N
ATOM 3718 C ARG c 87 -0.412 0.245 -39.620 1.00 26.41 CATOM 3718 C ARG c 87 -0.412 0.245 -39.620 1.00 26.41 C
ATOM 3719 0 ARG c 87 -0.269 - 0.699 -40.399 1.00 26.64 0 ATOM 3720 N ALA C 88 -0.701 0.083 - 38.336 1.00 23.53 NATOM 3719 0 ARG c 87 -0.269-0.699 -40.399 1.00 26.64 0 ATOM 3720 N ALA C 88 -0.701 0.083-38.336 1.00 23.53 N
ATOM 3721 CA ALA G 88 -0.331 - 1.139 - 37.653 1. 00 21.34 CATOM 3721 CA ALA G 88 -0.331-1.139-37.653 1. 00 21.34 C
ATOM 3722 CB ALA C 88 -0.761 - 1.069 - 36.209 1. 00 21.59 CATOM 3722 CB ALA C 88 -0.761-1.069-36.209 1. 00 21.59 C
ATOM 3723 C ALA C 88 -0.882 -2.404 -38.325 1. 00 23.73 CATOM 3723 C ALA C 88 -0.882 -2.404 -38.325 1. 00 23.73 C
ATOM 3724 0 ALA C 88 - 0.212 -3.437 -38.340 1. 00 25.01 0ATOM 3724 0 ALA C 88-0.212 -3.437 -38.340 1. 00 25.01 0
ATOM 3725 N GLY C 89 - 2.082 -2.326 -38.897 1. 00 22.35 NATOM 3725 N GLY C 89-2.082 -2.326 -38.897 1.00 22.35 N
ATOM 3726 CA GLY C 89 -2.622 -3.464 - 39. 628 1. 00 23.34 CATOM 3726 CA GLY C 89 -2.622 -3.464-39. 628 1. 00 23.34 C
ATOM 3727 C GLY C 89 -1.695 -4.064 -40. 686 1. 00 22.86 CATOM 3727 C GLY C 89 -1.695 -4.064 -40. 686 1. 00 22.86 C
ATOM 3728 0 GLY C 89 -1.669 - 5.274 -40. 878 1. 00 23.87 0ATOM 3728 0 GLY C 89 -1.669-5.274 -40. 878 1. 00 23.87 0
ATOM 3729 N LEU C 90 - 0.930 - 3.229 - 41. 376 1. 00 22.86 NATOM 3729 N LEU C 90-0.930-3.229-41. 376 1. 00 22.86 N
ATOM 3730 CA LEU C 90 -0.043 -3.711 -42. 434 1. 00 23.57 CATOM 3730 CA LEU C 90 -0.043 -3.711 -42. 434 1. 00 23.57 C
ATOM 3731 CB LEU C 90 0.792 - 2.568 - 43. 006 1. 00 21.55 CATOM 3731 CB LEU C 90 0.792-2.568-43. 006 1. 00 21.55 C
ATOM 3732 CG LEU c 90 0.048 -1.533 -43. 844 1 00 25.12 CATOM 3732 CG LEU c 90 0.048 -1.533 -43. 844 1 00 25.12 C
ATOM 3733 CD1 LEU c 90 1.020 -0.450 -44. 266 1. 00 24.95 CATOM 3733 CD1 LEU c 90 1.020 -0.450 -44. 266 1. 00 24.95 C
ATOM 3734 CD2 LEU c 90 - 0.579 -2.191 - 45. 061 1. 00 24.48 CATOM 3734 CD2 LEU c 90-0.579 -2.191-45. 061 1. 00 24.48 C
ATOM 3735 C LEU c 90 0.895 -4.786 -41. 914 1. 00 22.23 CATOM 3735 C LEU c 90 0.895 -4.786 -41. 914 1. 00 22.23 C
ATOM 3736 0 LEU c 90 1.305 -5.664 - 42. 658 1. 00 24.66 0ATOM 3736 0 LEU c 90 1.305 -5.664-42. 658 1. 00 24.66 0
ATOM 3737 N GLY c 91 1.225 —4.710 -40. 632 1. ,00 21.67 NATOM 3737 N GLY c 91 1.225 —4.710 -40. 632 1., 00 21.67 N
ATOM 3738 CA GLY c 91 2.189 -5.628 -40. 055 1. ,00 22.09 CATOM 3738 CA GLY c 91 2.189 -5.628 -40. 055 1., 00 22.09 C
ATOM 3739 C GLY c 91 1.657 -7.024 -39. 805 1. 00 23.05 CATOM 3739 C GLY c 91 1.657 -7.024 -39. 805 1.00 23.05 C
ATOM 3740 0 GLY c 91 2.415 - 7.929 -39. 449 1. ,00 25.46 0ATOM 3740 0 GLY c 91 2.415-7.929 -39. 449 1., 00 25.46 0
ATOM 3741 N MET c 92 0.353 - 7.202 -39. 976 1. ,00 21.48 NATOM 3741 N MET c 92 0.353-7.202 -39. 976 1., 00 21.48 N
ATOM 3742 CA MET c 92 -0.259 -8.514 -39.849 1. ,00 20.67 CATOM 3742 CA MET c 92 -0.259 -8.514 -39.849 1., 00 20.67 C
ATOM 3743 CB MET c 92 -1.514 -8.433 -38. 977 1. .00 20.56 CATOM 3743 CB MET c 92 -1.514 -8.433 -38. 977 1. .00 20.56 C
ATOM 3744 CG MET c 92 -1.230 -8.329 -37. 498 1. .00 22.15 CATOM 3744 CG MET c 92 -1.230 -8.329 -37. 498 1. .00 22.15 C
ATOM 3745 SD MET c 92 -2.663 - 7.823 - 36. 560 1, .00 27.11 SATOM 3745 SD MET c 92 -2.663-7.823-36. 560 1, .00 27.11 S
ATOM 3746 CE MET c 92 -3.677 - 9.330 - 36. 663 1, .00 25.33 CATOM 3746 CE MET c 92 -3.677-9.330-36. 663 1, .00 25.33 C
ATOM 3747 C MET c 92 -0.627 - 9.043 -41. 229 1, .00 22.66 CATOM 3747 C MET c 92 -0.627-9.043 -41. 229 1, .00 22.66 C
ATOM 3748 0 MET c 92 -0.981 -10.213 - 41. 376 1, .00 22.52 0ATOM 3748 0 MET c 92 -0.981 -10.213-41. 376 1, .00 22.52 0
ATOM 3749 N MET c 93 -0.532 - 8.179 -42. 240 1, .00 23.03 NATOM 3749 N MET c 93 -0.532-8.179 -42. 240 1, .00 23.03 N
ATOM 3750 CA MET c 93 -1.124 - 8.475 -43. 539 1, .00 24.67 CATOM 3750 CA MET c 93 -1.124-8.475 -43. 539 1, .00 24.67 C
ATOM 3751 CB MET c 93 -1.026 -7.263一 44. 480 1 .00 24.72 CATOM 3751 CB MET c 93 -1.026 -7.263 One 44. 480 1 .00 24.72 C
ATOM 3752 CG MET c 93 -1.910 -7.384 -45. 723 1 ■ 00 25.93 CATOM 3752 CG MET c 93 -1.910 -7.384 -45. 723 1 ■ 00 25.93 C
ATOM 3753 SD MET c 93 -1.728 -6.006 - 46. 895 1 • 00 32.45 SATOM 3753 SD MET c 93 -1.728 -6.006-46. 895 1 • 00 32.45 S
ATOM 3754 CE MET c 93 0.003 -5.597 -46. 675 1 • 00 28.34 CATOM 3754 CE MET c 93 0.003 -5.597 -46. 675 1 • 00 28.34 C
ATOM 3755 C MET c 93 -0.513 -9.696 -44. 211 1 ■ 00 23.09 C ATOM 3756 0 MET C 93 -1.244 -10.535 -44.736 1.00 23.91 0ATOM 3755 C MET c 93 -0.513 -9.696 -44. 211 1 ■ 00 23.09 C ATOM 3756 0 MET C 93 -1.244 -10.535 -44.736 1.00 23.91 0
ATOM 3757 N ASP C 94 0.815 - 9.805 -44.188 1. 00 23.60 ΝATOM 3757 N ASP C 94 0.815-9.805 -44.188 1. 00 23.60 Ν
ATOM 3758 CA ASP C 94 1.500 -10.922 -44.842 1. 00 24.31 CATOM 3758 CA ASP C 94 1.500 -10.922 -44.842 1.00 24.31 C
ATOM 3759 CB ASP G 94 3.023 -10.771 -44.747 1. 00 22.61 CATOM 3759 CB ASP G 94 3.023 -10.771 -44.747 1. 00 22.61 C
ATOM 3760 CG ASP C 94 3.574 - 9.747 -45.726 1. 00 26.40 CATOM 3760 CG ASP C 94 3.574-9.747 -45.726 1. 00 26.40 C
ATOM 3761 0D1 ASP C 94 2.835 - 9.355 - 46.654 1. 00 25.09 0ATOM 3761 0D1 ASP C 94 2.835-9.355-46.654 1.00 25.09 0
ATOM 3762 0D2 ASP C 94 4.748 -9.337 - 45. 564 1. 00 26.38 0ATOM 3762 0D2 ASP C 94 4.748 -9.337-45. 564 1. 00 26.38 0
ATOM 3763 C ASP C 94 1.098 -12.254 —44. 213 1. 00 25.29 CATOM 3763 C ASP C 94 1.098 -12.254 —44. 213 1. 00 25.29 C
ATOM 3764 0 ASP C 94 1.037 -13.282 —44. 893 1. 00 25.50 0ATOM 3764 0 ASP C 94 1.037 -13.282 --44. 893 1. 00 25.50 0
ATOM 3765 N GLY C 95 0.830 -12. 226 -42. 913 1. 00 24.00 ΝATOM 3765 N GLY C 95 0.830 -12. 226 -42. 913 1. 00 24.00 Ν
ATOM 3766 CA 6LY C 95 0.532 -13. 449 -42. 198 1. 00 26.00 CATOM 3766 CA 6LY C 95 0.532 -13. 449 -42. 198 1. 00 26.00 C
ATOM 3767 C GLY C 95 -0.812 -13. 98.4 -42. 640 1. 00 27.41 CATOM 3767 C GLY C 95 -0.812 -13. 98.4 -42. 640 1. 00 27.41 C
ATOM 3768 0 GLY C 95 -1 · 000 -15 200 -42. 744 1. 00 27.95 0ATOM 3768 0 GLY C 95 -1 000 -15 200 -42.744 1.00 27.95 0
ATOM 3769 N VAL C 96 -1.743 -13. 080 -42. 924 1. 00 25.41 ΝATOM 3769 N VAL C 96 -1.743 -13. 080 -42. 924 1. 00 25.41 Ν
ATOM 3770 CA VAL C 96 - 3.045 -13. 495 -43. 435 1. 00 25.35 CATOM 3770 CA VAL C 96-3.045 -13. 495 -43. 435 1. 00 25.35 C
ATOM 3771 CB VAL C 96 -4.050一 12, 323 - 43. 474 1. ,00 24.50 CATOM 3771 CB VAL C 96 -4.050 1 12, 323-43. 474 1., 00 24.50 C
ATOM 3772 CG1 VAL C 96 -5.322 -12. 756 -44. 184 1. ,00 23.33 GATOM 3772 CG1 VAL C 96 -5.322 -12. 756 -44. 184 1., 00 23.33 G
ATOM 3773 CG2 VAL C 96 -4.355 - 11. 858 -42. 063 1. 00 25.84 CATOM 3773 CG2 VAL C 96 -4.355-11. 858 -42. 063 1. 00 25.84 C
ATOM 3774 C VAL C 96 -2.920 -14. 060 -44. 839 1. ,00 24.38 CATOM 3774 C VAL C 96 -2.920 -14. 060 -44. 839 1., 00 24.38 C
ATOM 3775 0 VAL C 96 -3.534 -15. 077 -45. 158 1. ,00 22.65 0ATOM 3775 0 VAL C 96 -3.534 -15. 077 -45. 158 1., 00 22.65 0
ATOM 3776 N LEU C 97 -2.124 -13. 397 - 45. 674 1. ,00 25.11 ΝATOM 3776 N LEU C 97 -2.124 -13. 397-45. 674 1., 00 25.11 Ν
ATOM 3777 CA LEU C 97 -1.998 -13. 774 -47. 082 1. .00 25.99 CATOM 3777 CA LEU C 97 -1.998 -13. 774 -47. 082 1. .00 25.99 C
ATOM 3778 CB LEU G 97 -1.295 -12. 658 - 47.868 1. .00 21.71 CATOM 3778 CB LEU G 97 -1.295 -12. 658-47.868 1. .00 21.71 C
ATOM 3779 CG LEU C 97 -2.039 -11. 314 -47. 913 1. .00 23.68 CATOM 3779 CG LEU C 97 -2.039 -11. 314 -47. 913 1. .00 23.68 C
ATOM 3780 CD1 LEU C 97 -1.112 - 10. 222 -48. 448 1. .00 19.17 CATOM 3780 CD1 LEU C 97 -1.112-10. 222 -48. 448 1. .00 19.17 C
ATOM 3781 CD2 LEU C 97 -3.302 - 11. 449 -48. 776 1, .00 18.82 CATOM 3781 CD2 LEU C 97 -3.302-11. 449 -48. 776 1, .00 18.82 C
ATOM 3782 C LEU C 97 - 1.243 -15. 097 -47. 265 1. .00 27.34 CATOM 3782 C LEU C 97-1.243 -15. 097 -47. 265 1. .00 27.34 C
ATOM 3783 0 LEU C 97 -1.470 -15. 815 - 48. 242 1. .00 27.28 0ATOM 3783 0 LEU C 97 -1.470 -15. 815-48. 242 1. .00 27.28 0
ATOM 3784 N GLU C 98 -0.350 -15. 423 -46. 333 1, .00 28.39 ΝATOM 3784 N GLU C 98 -0.350 -15. 423 -46. 333 1, .00 28.39 Ν
ATOM 3785 CA GLU C 98 0.288 -16. 741 -46. 342 1, .00 31.36 GATOM 3785 CA GLU C 98 0.288 -16. 741 -46. 342 1, .00 31.36 G
ATOM 3786 CB GLU C 98 1.045 -16. 996一 45. 033 1, .00 36.73 CATOM 3786 CB GLU C 98 1.045 -16. 996 One 45. 033 1, .00 36.73 C
ATOM 3787 CG GLU C 98 2.258 -16. 120 -44. 781 1 .00 42.53 GATOM 3787 CG GLU C 98 2.258 -16. 120 -44. 781 1 .00 42.53 G
ATOM 3788 CD GLU c 98 2.953 -16. 465 -43. 463 1 .00 47.85 CATOM 3788 CD GLU c 98 2.953 -16. 465 -43. 463 1 .00 47.85 C
ATOM 3789 0E1 GLU c 98 3.633 - 15. 577 -42. 891 1, .00 50.38 0ATOM 3789 0E1 GLU c 98 3.633-15. 577 -42. 891 1, .00 50.38 0
ATOM 3790 0E2 GLU c 98 2.818 -17. 624 -42. 998 1 ■ 00 46.16 0ATOM 3790 0E2 GLU c 98 2.818 -17. 624 -42. 998 1 ∎ 00 46.16 0
ATOM 3791 C GLU c 98 - 0· 793一 17. 813 -46. 493 1 • 00 29.34 C ATOM 3792 0 GLU C 98 - 0.652 - 18.743 -47.284 1.00 30.95 0ATOM 3791 C GLU c 98-0 793 1 17. 813 -46. 493 1 • 00 29.34 C ATOM 3792 0 GLU C 98-0.652-18.743 -47.284 1.00 30.95 0
ATOM 3793 N ASN C 99 —1.871 -17.663 -45.727 1. 00 26.45 NATOM 3793 N ASN C 99 —1.871 -17.663 -45.727 1. 00 26.45 N
ATOM 3794 CA ASN C 99 - 2.952 -18.645 - 45.678 1. 00 24.22 CATOM 3794 CA ASN C 99-2.952 -18.645-45.678 1. 00 24.22 C
ATOM 3795 CB ASN G 99 -3.772 -18.453 - 44.402 1. 00 20.56 CATOM 3795 CB ASN G 99 -3.772 -18.453-44.402 1. 00 20.56 C
ATOM 3796 CG ASN C 99 - 3.001 - 18.842 - 43.161 1. 00 22.65 CATOM 3796 CG ASN C 99-3.001-18.842-43.161 1. 00 22.65 C
ATOM 3797 0D1 ASN C 99 -3.065 -19.987 -42.719 1. 00 23.58 0ATOM 3797 0D1 ASN C 99 -3.065 -19.987 -42.719 1. 00 23.58 0
ATOM 3798 ND2 ASN C 99 -2.252 -17.896 -42.598 1. 00 19.92 NATOM 3798 ND2 ASN C 99 -2.252 -17.896 -42.598 1. 00 19.92 N
ATOM 3799 C ASN C 99 -3.877 -18.590 -46.884 1. 00 25.68 CATOM 3799 C ASN C 99 -3.877 -18.590 -46.884 1.00 25.68 C
ATOM 3800 0 ASN C 99 -4.383 -19.624 -47.334 1. 00 24.53 0ATOM 3800 0 ASN C 99 -4.383 -19.624 -47.334 1.00 24.53 0
ATOM 3801 N VAL C 100 -4.115 -17.380 - 47.391 1. 00 24.46 NATOM 3801 N VAL C 100 -4.115 -17.380-47.391 1. 00 24.46 N
ATOM 3802 CA VAL C 100 -5.048 -17.181 -48.498 1. 00 24.57 CATOM 3802 CA VAL C 100 -5.048 -17.181 -48.498 1. 00 24.57 C
ATOM 3803 .CB VAL C 100 -6.415 - 16.658 -47.990 1. 00 27.45 CATOM 3803 .CB VAL C 100 -6.415-16.658 -47.990 1.00 27.45 C
ATOM 3804 CG1 VAL C 100 - 7.398 -16.556 - 49.143 1. 00 29.53 . CATOM 3804 CG1 VAL C 100-7.398 -16.556-49.143 1. 00 29.53. C
ATOM 3805 CG2 VAL C 100 -6.971 -17.587 - 46.925 1. 00 27.76 GATOM 3805 CG2 VAL C 100 -6.971 -17.587-46.925 1.00 27.76 G
ATOM 3806 C VAL C ioo - 4.442 - 16.170 -49.472 1. 00 24.78 CATOM 3806 C VAL C ioo-4.442-16.170 -49.472 1. 00 24.78 C
ATOM 3807 0 VAL C 100 -4.880 -15.026 -49.558 1. 00 22.21 0ATOM 3807 0 VAL C 100 -4.880 -15.026 -49.558 1. 00 22.21 0
ATOM 3808 N PRO C 101 -3.402 -16.591 -50.212 1. 00 25.46 NATOM 3808 N PRO C 101 -3.402 -16.591 -50.212 1. 00 25.46 N
ATOM 3809 CD PRO C 101 - 2.899 -17.975 - 50.205 1. 00 23.98 CATOM 3809 CD PRO C 101-2.899 -17.975-50.205 1.00 23.98 C
ATOM 3810 CA PRO C 101 -2.592 -15.723 -51.071 1. ,00 26.72 CATOM 3810 CA PRO C 101 -2.592 -15.723 -51.071 1., 00 26.72 C
ATOM 3811 CB PRO C 101 - 1.444 -16.625 -51.524 1. ,00 25.81 CATOM 3811 CB PRO C 101-1.444 -16.625 -51.524 1., 00 25.81 C
ATOM 3812 CG PRO C 101 -1.968一 17.995 -51.384 1. .00 25.88 CATOM 3812 CG PRO C 101 -1.968 1 17.995 -51.384 1. .00 25.88 C
ATOM 3813 C PRO C 101 - 3.354 -15.132 - 52.250 1. .00 28.11 CATOM 3813 C PRO C 101-3.354 -15.132-52.250 1. .00 28.11 C
ATOM 3814 0 PRO C 101 - 2.824 -14.291 -52.976 1. .00 27.00 0ATOM 3814 0 PRO C 101-2.824 -14.291 -52.976 1. .00 27.00 0
ATOM 3815 N SER C 102 - 4.590 -15.579 -52.438 1. .00 28.79 NATOM 3815 N SER C 102-4.590 -15.579 -52.438 1. .00 28.79 N
ATOM 3816 CA SER C 102 -5.426 -15.084 -53.526 1, .00 31.06 CATOM 3816 CA SER C 102 -5.426 -15.084 -53.526 1, .00 31.06 C
ATOM 3817 CB SER C 102 -6.210 -16.239 -54.154 1, .00 32.18 CATOM 3817 CB SER C 102 -6.210 -16.239 -54.154 1, .00 32.18 C
ATOM 3818 OG SER C 102 - 5.326 -17.185 -54.733 1. .00 38.18 0ATOM 3818 OG SER C 102-5.326 -17.185 -54.733 1. .00 38.18 0
ATOM 3819 C SER C 102 - 6.400 -14.000 -53.069 1. .00 29.96 CATOM 3819 C SER C 102-6.400 -14.000 -53.069 1. .00 29.96 C
ATOM 3820 0 SER c 102 -7.108 -13.420 -53.887 1. .00 30.15 0ATOM 3820 0 SER c 102 -7.108 -13.420 -53.887 1. .00 30.15 0
ATOM 3821 N ALA c 103 -6.437 - 13.736 -51.764 1, .00 28.37 NATOM 3821 N ALA c 103 -6.437-13.736 -51.764 1, .00 28.37 N
ATOM 3822 CA ALA c 103 -7.383 -12.775 -51.202 1, .00 27.48 CATOM 3822 CA ALA c 103 -7.383 -12.775 -51.202 1, .00 27.48 C
ATOM 3823 CB ALA c 103 -7.254 - 12.727 - 49.683 1, .00 24.82 CATOM 3823 CB ALA c 103 -7.254-12.727-49.683 1, .00 24.82 C
ATOM 3824 C ALA c 103 -7.160 -11.382 -51.770 1, .00 27.08 CATOM 3824 C ALA c 103 -7.160 -11.382 -51.770 1, .00 27.08 C
ATOM 3825 0 ALA c 103 -6.036 -10.999 -52.086 1 .00 26.01 0ATOM 3825 0 ALA c 103 -6.036 -10.999 -52.086 1 .00 26.01 0
ATOM 3826 N AR6 c 104 -8.248 -10.629 -51.886 1 .00 27.36 NATOM 3826 N AR6 c 104 -8.248 -10.629 -51.886 1 .00 27.36 N
ATOM 3827 CA AR6 c 104 -8.170 —9.205一 52.163 1 ■ 00 24.55 C ATOM 3828 CB ARG C 104 -9.559 -8.624 -52.382 1.00 27.39 CATOM 3827 CA AR6 c 104 -8.170 --9.205 1 52.163 1 ■ 00 24.55 C ATOM 3828 CB ARG C 104 -9.559 -8.624 -52.382 1.00 27.39 C
ATOM 3829 CG A G C 104 -10. 075 -8.719 -53.793 1. 00 31.79 CATOM 3829 CG A G C 104 -10. 075 -8.719 -53.793 1.00 31.79 C
ATOM 3830 CD ARG C 104 -11. 081 - 7.599 -54.050 1. 00 34.77 CATOM 3830 CD ARG C 104 -11. 081-7.599 -54.050 1.00 34.77 C
ATOM 3831 NE ARG C 104 - 11. 949 -7.390 -52.891 1. 00 34.79 NATOM 3831 NE ARG C 104-11. 949 -7.390 -52.891 1.00 34.79 N
ATOM 3832 CZ AR6 C 104 -13. 063 -6.664 - 52. 909 1. 00 35.51 CATOM 3832 CZ AR6 C 104 -13. 063 -6.664-52. 909 1. 00 35.51 C
ATOM 3833 NH1 ARG C 104 -13. 790 -6.533 -51. 804 1. 00 35.08 NATOM 3833 NH1 ARG C 104 -13. 790 -6.533 -51. 804 1. 00 35.08 N
ATOM 3834 NH2 ARG C 104 -13. 449 -6.072 -54. 030 1. 00 33.41 NATOM 3834 NH2 ARG C 104 -13. 449 -6.072 -54. 030 1. 00 33.41 N
ATOM 3835 C ARG C 104 - 7. 537 -8.504 - 50. 977 1. 00 23.94 CATOM 3835 C ARG C 104-7. 537 -8.504-50. 977 1. 00 23.94 C
ATOM 3836 0 ARG C 104 - 7, 506 - 9.036 -49. 868 1. 00 22.12 0ATOM 3836 0 ARG C 104-7, 506-9.036 -49. 868 1. 00 22.12 0
ATOM 3837 N ILE C 105 -7. 032 -7.304 -51. 224 1. 00 21.61 NATOM 3837 N ILE C 105 -7. 032 -7.304 -51. 224 1. 00 21.61 N
ATOM 3838 CA ILE C 105 - 6. 557 -6.452 -50. 162 1. 00 21.64 CATOM 3838 CA ILE C 105-6. 557 -6.452 -50. 162 1. 00 21.64 C
ATOM 3839 ■CB ILE C 105 -5. 032 -6.286 -50. 242 1. 00 23.38 CATOM 3839 CB ILE C 105 -5. 032 -6.286 -50. 242 1. 00 23.38 C
ATOM 3840 C62 ILE C 105 -4. 535 -5.429 -49. 096 1. 00 21.02 CATOM 3840 C62 ILE C 105 -4. 535 -5.429 -49. 096 1. 00 21.02 C
ATOM 3841 C61 ILE C 105 - 4.369 - 7.669 -50. 194 1. 00 25.64 CATOM 3841 C61 ILE C 105-4.369-7.669 -50. 194 1. 00 25.64 C
ATOM 3842 CD1 ILE C 105 -2. 853 -7.627 -50. 232 1. 00 27.03 CATOM 3842 CD1 ILE C 105 -2. 853 -7.627 -50. 232 1. 00 27.03 C
ATOM 3843 C ILE C 105 - 7. 236 -5.101 -50. 301 1. 00 22.16 CATOM 3843 C ILE C 105-7. 236 -5.101 -50. 301 1.00 22.16 C
ATOM 3844 0 ILE C 105 - 7. 164 - 4.469 -51. 357 1. 00 23.34 0ATOM 3844 0 ILE C 105-7. 164-4.469 -51. 357 1. 00 23.34 0
ATOM 3845 N SER C 106 -7. 922 -4.671 -49. 243 1. 00 21.82 NATOM 3845 N SER C 106 -7. 922 -4.671 -49. 243 1. 00 21.82 N
ATOM 3846 CA SER C 106 -8. 498 -3.334 -49. 204 1. 00 21.06 CATOM 3846 CA SER C 106 -8. 498 -3.334 -49. 204 1. 00 21.06 C
ATOM 3847 CB SER C 106 - 10. 024 -3.395 -49. 176 1. 00 24.14 CATOM 3847 CB SER C 106-10. 024 -3.395 -49. 176 1. 00 24.14 C
ATOM 3848 OG SER C 106 -10. 533 - 3.932 -50. 384 1. ,00 30.32 0ATOM 3848 OG SER C 106 -10. 533-3.932 -50. 384 1., 00 30.32 0
ATOM 3849 G SER C 106 - 8. 000 -2.627 -47. 962 1. ,00 21.73 CATOM 3849 G SER C 106-8. 000 -2.627 -47. 962 1., 00 21.73 C
ATOM 3850 0 SER C 106 - 8. 523 -2.832 - 46· 867 1. .00 21.65 0ATOM 3850 0 SER C 106-8. 523 -2.832-46 867 1. .00 21.65 0
ATOM 3851 N VAL C 107 -6. 980 -1.800 -48. 140 1. ,00 20.86 NATOM 3851 N VAL C 107 -6. 980 -1.800 -48. 140 1., 00 20.86 N
ATOM 3852 CA VAL c 107 - 6. 440 -1.015 -47. 048 1. ,00 21.20 CATOM 3852 CA VAL c 107-6. 440 -1.015 -47. 048 1., 00 21.20 C
ATOM 3853 CB VAL c 107 -5. 130 -0.329 -47. 483 1. ,00 21.47 CATOM 3853 CB VAL c 107 -5. 130 -0.329 -47. 483 1., 00 21.47 C
ATOM 3854 CG1 VAL c 107 -4.660 0.614 -46. 409 1. ,00 23.78 CATOM 3854 CG1 VAL c 107 -4.660 0.614 -46. 409 1., 00 23.78 C
ATOM 3855 CG2 VAL c 107 -4. 059 -1.380 -47. 767 1. .00 21.68 CATOM 3855 CG2 VAL c 107 -4. 059 -1.380 -47. 767 1. .00 21.68 C
ATOM 3856 C VAL c 107 -7. 464 0.037 -46. 618 1. .00 21.35 CATOM 3856 C VAL c 107 -7. 464 0.037 -46. 618 1. .00 21.35 C
ATOM 3857 0 VAL c 107 -8. 109 0.668 -47. 449 1. .00 21.49 0ATOM 3857 0 VAL c 107 -8. 109 0.668 -47. 449 1. .00 21.49 0
ATOM 3858 N VAL c 108 -7. ,620 0.206 -45. 315 1. .00 21.97 NATOM 3858 N VAL c 108 -7., 620 0.206 -45. 315 1. .00 21.97 N
ATOM 3859 CA VAL c 108 - 8. ,502 1.226 -44. 772 1, .00 21.77 CATOM 3859 CA VAL c 108-8., 502 1.226 -44. 772 1, .00 21.77 C
ATOM 3860 CB VAL c 108 -9. 630 0.604 -43. 931 1, .00 20.25 CATOM 3860 CB VAL c 108 -9. 630 0.604 -43. 931 1, .00 20.25 C
ATOM 3861 CG1 VAL c 108 -10. ,410 1.705 -43. , 195 1 .00 19.95 CATOM 3861 CG1 VAL c 108 -10., 410 1.705 -43., 195 1 .00 19.95 C
ATOM 3862 C62 VAL c 108 -10. ,572 -0.182 -44. ,835 1 .00 23.16 CATOM 3862 C62 VAL c 108 -10., 572 -0.182 -44., 835 1 .00 23.16 C
ATOM 3863 C VAL c 108 -7. ,700 2.163 -43. ,892 1 .00 24.27 C 9ST ATOM 3863 C VAL c 108 -7., 700 2.163 -43., 892 1 .00 24.27 C 9ST
0 L8 83 00 L SOS ん ε - ε89 ·9- Zii 0 0 668 W01V 0 L8 83 00 L SOS ε-ε89 9- Zii 0 0 668 W01V
0 08 "L9 00 L SZL ε- Ζΐ9 ΈΙ l£L 'L- Zll 0 9¾V 0 868E W01V0 08 "L9 00 L SZL ε- Ζΐ9 ΈΙ l £ L 'L- Zll 0 9¾V 0 868E W01V
N 09 00 ι 016 frS - ½6' 0Z.9 ,ん- Zll 0 gyv 3HN ん 68ε 匪 VN 09 00 ι 016 frS-½6 '0Z.9, N-Zll 0 gyv 3HN 68ε 匪 V
N 88 00 L 6frl 098 ·8 - ZU 0 IHN 968 W01VN 88 00 L 6frl 098 8-ZU 0 IHN 968 W01V
0 n' 00 ι 398 ε- 9VZ'L 9Z.fr 'L- Zll 0 DMV ZO 9688 IN01V0 n '00 ι 398 ε- 9VZ'L 9Z.fr' L- Zll 0 DMV ZO 9688 IN01V
N 00 ι 9½ ■ss - ZL8'L £Z5 "9- Zll 0 DMV 3N 68ε 匪 VN 00 ι 9½ ss-ZL8'L £ Z5 "9- Zll 0 DMV 3N 68ε 匪 V
3 69 OS 00 ι S89 5ε- ZZS ·6 9SS ·9- Zll 0 9¾V GO 68ε 碰 V3 69 OS 00 ι S89 5ε- ZZS 6 9SS 9- Zll 0 9¾V GO 68ε 碰 V
0 8S'6fr 00 L 91Ζ. -9ε- εε6·6 Z.9L 'L - Zll 0 EWV DO 268C IN01V0 8S'6fr 00 L 91Ζ.-9ε- εε6 ・ 6 Z.9L 'L-Zll 0 EWV DO 268C IN01V
0 69 '8fr 00 L 288 ■9ε-
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906 ·9- Zii 0 9¾V ao L68S IN01V0 69 '8fr 00 L 288 9ε-
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0 93 '8fr 00 ι 59L ■£ε- 9Ζo tΙ 'ΖΙ Ot-6 'L- Zll 0 9yv V。 068ε 匪 V0 93 '8fr 00 ι 59L ■ £ ε- 9Ζo tΙ' ΖΙ Ot-6 'L- Zll 0 9yv V. 068ε 匪 V
N S9 'ε 00 L ΖΙ ■6ε- 609■ U S88 ん- Zll 0 DMV . N 688 隱 VN S9 'ε 00 L ΖΙ 6ε- 609 U S88-Zll 0 DMV. N 688 隱 V
0 09 Z 00 L SLO ·6ε- 8^6 ΌΙ 120 '0卜 III 0 人丄 0 8888 WOIV0 09 Z 00 L SLO 6ε- 8 ^ 6 ΌΙ 120 '0 卜 III 0 Human 0 0 8888 WOIV
0 S9'Lfr 00 L 089 ■6ε- 690 'U L96 '8- III 0 M人丄 0 Ζ.88 W01V0 S9'Lfr 00 L 089 6ε- 690 'U L96' 8- III 0 M Human 丄 0 Ζ.88 W01V
0 0fr'6fr 00 L 9C9 ' - 6ε . OL ·6- III 0 HO 9888 WOIV0 0fr'6fr 00 L 9C9 '-6ε .OL 6-III 0 HO 9888 WOIV
〇 L0 OS 00 L 893 ■9fr- 868 '01· 2t-9 "6- III 0 y人丄 ZO 988C WOIV〇 L0 OS 00 L 893 9fr- 868 '01 2t-9 "6- III 0 y People ZO 988C WOIV
0 9Z "8fr 00 L fr99 ■Sfr - 098 ΌΙ C8Z. '01·— III 0 y人丄 330 88ε WOIV0 9Z "8fr 00 L fr99 ■ Sfr-098 ΌΙ C8Z. '01 · —III 0 y person 丄 330 88ε WOIV
0 LL '8fr 00 1 8LZ ■η- SOO'll 088 L- III 0 y人丄 200 ε88ε WOIV0 LL '8fr 00 1 8LZ η- SOO'll 088 L- III 0 y Human 200 ε88ε WOIV
0 69 '6f 00 L 209 L80'LL LOfr "8- lil 0 y人丄 L30 388ε WOIV0 69 '6f 00 L 209 L80'LL LOfr "8- lil 0 y Human L30 388ε WOIV
0 00 L Lll n- 609 "8- III 0 M人丄 Lao 188ε WOIV0 00 L Lll n- 609 "8- III 0 M Human Lao 188ε WOIV
0 S8.9 00 L ■Sfr - 8W '6- III 0 DO 088ε WOIV0 S8.9 00 LSfr-8W '6- III 0 DO 088ε WOIV
0 9V£ 00 L LL6 29ε " IL8 '6- III D M人丄 ao 6LS2 IN01V0 9V £ 00 L LL6 29ε "IL8 '6- III D M People ao 6LS2 IN01V
0 LQ Ofr 00 L IZl ' - 369 ΌΙ "8- IU 0 y人丄 vo 8 8ε WOIV0 LQ Ofr 00 L IZl '-369 ΌΙ "8- IU 0 y people vo 8 8ε WOIV
N 18'Ζ.ε 00 L Wl 29 L ·6 960 "6- III 0 y人丄 N LL8Z WOIVN 18'Ζ.ε 00 L Wl 29 L6 960 `` 6- III 0 y People 丄 N LL8Z WOIV
0 . 08-3ε 00 L 929 - 8L9 "8 900 'L - on 0 丄ョ IN 0 9 8ε WOIV0 .08-3ε 00 L 929-8L9 "8 900 'L-on 0 IN IN 0 9 8ε WOIV
0 80 "9ε 00 •1 SW_ ηζ ·8 89 L "8- OIL 0 丄ョ W 0 9Z.8C WOIV0 80 "9ε 00 • 1 SW_ ηζ 8 89 L" 8- OIL 0 丄 W 0 9Z.8C WOIV
0 8ん '6ε 00 "1 6Z.8 ' ε - 909 9 L6Z · 11- 0は 0 丄ョ W 30 WOIV s 00 Ί 9 90S L9 Ot- Oil 0 13W as ε 8ε NOiV0 8 '6ε 00' '1 6Z.8' ε-909 9 L6Z11-0 is 0 W W 30 WOIV s 00 Ί 9 90S L9 Ot- Oil 0 13W as ε 8ε NOiV
0 08.9S 00 Ί ZOS ■βε- LZ.6 6 L '8- Oil 0 丄ョ IN 90 ZL Z WOIV0 08.9S 00 Ί ZOS βε- LZ.6 6 L '8- Oil 0 IN IN 90 ZL Z WOIV
0 Ζ.8'9ε 00 L LLO ■6ε- 6S 9 96 '8- Oil 0 丄ョ IN ao VL 2 IN01V0 Ζ.8'9ε 00 L LLO 6ε-6S 9 96 '8- Oil 0 IN IN ao VL 2 IN01V
0 8 "9 00 'ϊ LS9 ■017- ZZQ ,9 009 '8- OIL 0 13W vo ο乙 8ε WOIV0 8 "9 00 'ϊ LS9 017- ZZQ, 9 009' 8- OIL 0 13W vo
N 83 '3 00 "L ■ - 2S6.S Z9L 'L- OIL 0 丄ョ W N 6988 WOIVN 83 '3 00 "L ■-2S6.S Z9L' L- OIL 0 丄 W N 6988 WOIV
0 60 '62 00 Ί zn 886 LLP '6— 60 L 0 A19 0 898 WOIV0 60 '62 00 Ί zn 886 LLP '6— 60 L 0 A19 0 898 WOIV
0 69 "63 00 "1 m ' — L i -S OLZ -8- 601 D AID 0 ん 98ε WOIV0 69 "63 00" 1 m '— L i -S OLZ -8- 601 D AID 0 98ε WOIV
0 29 "83 00 Ί SSfr ZLZ 'L - 601. 0 kid vo 9988 WOIV0 29 "83 00 Ί SSfr ZLZ 'L-601.0 0 kid vo 9988 WOIV
N 89'£3 00 Ί 990 n- 9P ·ε 816 '一 60 L 〇 人つ 9 N 5988 WOIVN 89 '£ 3 00 Ί 990 n- 9P ε 816' One 60 L 〇 9 N 5988 WOIV
0 89 00 .L LQO 'Sfr— OZL'l 068.9— 80 L 0 1VA 0 8S WOIV 0 89 00 .L LQO 'Sfr— OZL'l 068.9— 80 L 0 1VA 0 8S WOIV
SS.lZ,0/.00Zdf/X3d 0£Z.S0/600Z OAV 1755 SS.lZ, 0 / .00Zdf / X3d 0 £ Z.S0 / 600Z OAV 1755
ATOM 3900 N ASN C 113 -8.749 14.361 -38.173 1. 00 54.15 NATOM 3900 N ASN C 113 -8.749 14.361 -38.173 1. 00 54.15 N
ATOM 3901 CA ASN c 113 -8.729 15.818 -38.178 1. 00 56.01 CATOM 3901 CA ASN c 113 -8.729 15.818 -38.178 1. 00 56.01 C
ATOM 3902 CB ASN c 113 -9.417 16.335 - 39.449 1. 00 57.57 CATOM 3902 CB ASN c 113 -9.417 16.335-39.449 1. 00 57.57 C
ATOM 3903 CG ASN c 113 -9.168 17.812 -39.697 1. 00 58.80 CATOM 3903 CG ASN c 113 -9.168 17.812 -39.697 1.00 58.80 C
ATOM 3904 0D1 ASN c 113 -8.496 18.485 -38. 916 1. 00 59.32 0ATOM 3904 0D1 ASN c 113 -8.496 18.485 -38. 916 1.00 59.32 0
ATOM 3905 ND2 ASN c 113 -9.716 18.324 - 40. 796 1. 00 59.50 NATOM 3905 ND2 ASN c 113 -9.716 18.324-40. 796 1. 00 59.50 N
ATOM 3906 C ASN c 113 -9.465 16.316 -36. 936 1. 00 57.02 CATOM 3906 C ASN c 113 -9.465 16.316 -36.936 1. 00 57.02 C
ATOM 3907 0 ASN c 113 -10.479 15.747 -36. 530 1. 00 57.04 0ATOM 3907 0 ASN c 113 -10.479 15.747 -36. 530 1. 00 57.04 0
ATOM 3908 N GLU c 114 -8.946 17.376 -36. 331 1. 00 57.67 NATOM 3908 N GLU c 114 -8.946 17.376 -36. 331 1. 00 57.67 N
ATOM 3909 CA GLU c 114 -9.518 17.912 -35. 101 1. 00 58.41 CATOM 3909 CA GLU c 114 -9.518 17.912 -35. 101 1. 00 58.41 C
ATOM 3910 CB GLU G 114 -8.554 18.927 -34. 488 1. 00 58.83 CATOM 3910 CB GLU G 114 -8.554 18.927 -34. 488 1. 00 58.83 C
ATOM 3911 CG GLU C 114 -7.086 18.598 -34. 732 1. 00 60.90 CATOM 3911 CG GLU C 114 -7.086 18.598 -34. 732 1. 00 60.90 C
ATOM 3912 CD GLU c 114 -6.658 18.848 -36. 175 1. 00 62.10 CATOM 3912 CD GLU c 114 -6.658 18.848 -36. 175 1. 00 62.10 C
ATOM 3913 0E1 GLU c 114 -6.631 20.028 - 36. 595 1. 00 63.06 0ATOM 3913 0E1 GLU c 114 -6.631 20.028-36. 595 1. 00 63.06 0
ATOM 3914 0E2 GLU c 114 -6.349 17.868 -36. 888 1. 00 60.87 0ATOM 3914 0E2 GLU c 114 -6.349 17.868 -36. 888 1. 00 60.87 0
ATOM 3915 C GLU c 114 - 10.863 18.580 -35. 386 1. 00 58.57 CATOM 3915 C GLU c 114-10.863 18.580 -35. 386 1. 00 58.57 C
ATOM 3916 0 GLU c 114 -11.810 18.461 -34. 604 1. 00 57.62 0ATOM 3916 0 GLU c 114 -11.810 18.461 -34. 604 1. 00 57.62 0
ATOM 3917 N GLU c 115 -10.938 19.272 -36. 518 1. 00 58.18 NATOM 3917 N GLU c 115 -10.938 19.272 -36. 518 1. 00 58.18 N
ATOM 3918 CA GLU c 115 -12.119 20.042 - 36. 880 1. ,00 57.99 CATOM 3918 CA GLU c 115 -12.119 20.042-36. 880 1., 00 57.99 C
ATOM 3919 CB GLU c 115 -11.746 21.111一 37. 910 1. .00 60.01 CATOM 3919 CB GLU c 115 -11.746 21.111 One 37. 910 1. .00 60.01 C
ATOM 3920 CG GLU c 115 -10.586 20.740 -38. 809 1. ,00 61.65 CATOM 3920 CG GLU c 115 -10.586 20.740 -38. 809 1., 00 61.65 C
ATOM 3921 CD GLU c 115 -9.485 - 38. 775 1. ,00 64.00 CATOM 3921 CD GLU c 115 -9.485-38. 775 1., 00 64.00 C
ATOM 3922 0E1 GLU c 115 - 9.283 22.472 -39.801 1. ,00 64.14 0ATOM 3922 0E1 GLU c 115-9.283 22.472 -39.801 1., 00 64.14 0
ATOM 3923 0E2 GLU c 115 -8.823 21.915 -37. 721 1. .00 64.82 0ATOM 3923 0E2 GLU c 115 -8.823 21.915 -37. 721 1. .00 64.82 0
ATOM 3924 C GLU c 115 -13.270 19.198 -37. 415 1. .00 56.87 CATOM 3924 C GLU c 115 -13.270 19.198 -37. 415 1. .00 56.87 C
ATOM 3925 0 GLU c 115 -14.334 19.726 -37. 745 1. .00 54.94 0ATOM 3925 0 GLU c 115 -14.334 19.726 -37. 745 1. .00 54.94 0
ATOM 3926 N THR c 116 -13.057 17.889 -37. 508 1, .00 56.42 NATOM 3926 N THR c 116 -13.057 17.889 -37. 508 1, .00 56.42 N
ATOM 3927 CA THR c 116 -14.125 16.976 -37. 903 1, .00 56.17 CATOM 3927 CA THR c 116 -14.125 16.976 -37. 903 1, .00 56.17 C
ATOM 3928 CB THR c 116 -13.644 15.995 -39. 001 1 .00 55.65 CATOM 3928 CB THR c 116 -13.644 15.995 -39. 001 1 .00 55.65 C
ATOM 3929 061 THR c 116 -14.716 15.113 -39. 355 1 .00 57.01 0ATOM 3929 061 THR c 116 -14.716 15.113 -39. 355 1 .00 57.01 0
ATOM 3930 CG2 THR c 116 -12.464 15.172 -38. 512 1 .00 56.03 CATOM 3930 CG2 THR c 116 -12.464 15.172 -38. 512 1 .00 56.03 C
ATOM 3931 C THR c 116 -14.631 16.191 -36. 690 1 ,00 56.08 CATOM 3931 C THR c 116 -14.631 16.191 -36.690 1, 00 56.08 C
ATOM 3932 0 THR c 116 -15.799 15.801 -36. 626 1 .00 54.81 0ATOM 3932 0 THR c 116 -15.799 15.801 -36. 626 1 .00 54.81 0
ATOM 3933 N LEU c 117 -13.742 15.970 -35. ,725 1 .00 57.42 NATOM 3933 N LEU c 117 -13.742 15.970 -35., 725 1 .00 57.42 N
ATOM 3934 CA LEU G 117 -14.127 15.380 -34. ,449 1 .00 58.43 CATOM 3934 CA LEU G 117 -14.127 15.380 -34., 449 1 .00 58.43 C
ATOM 3935 CB LEU G 117 -15.095 16.313一 33. .722 1 .00 59.70 C ATOM 3936 C6 LEU C 117 -14.606 17.719 - 33, 370 1.00 59.44 CATOM 3935 CB LEU G 117 -15.095 16.313 One 33..722 1 .00 59.70 C ATOM 3936 C6 LEU C 117 -14.606 17.719-33, 370 1.00 59.44 C
ATOM 3937 CD1 LEU C 117 -15.778 18.558 -32.882 1. 00 60.11 CATOM 3937 CD1 LEU C 117 -15.778 18.558 -32.882 1.00 60.11 C
ATOM 3938 CD2 LEU C 117 -13.528 17.626 -32.302 1. 00 61.07 CATOM 3938 CD2 LEU C 117 -13.528 17.626 -32.302 1. 00 61.07 C
ATOM 3939 C LEU C 117 - 14.790 14.022 -34.647 1. 00 58.32 CATOM 3939 C LEU C 117-14.790 14.022 -34.647 1. 00 58.32 C
ATOM 3940 0 LEU C 117 -15.780 13.709 -33.983 1. 00 58.11 0ATOM 3940 0 LEU C 117 -15.780 13.709 -33.983 1.00 58.11 0
ATOM 3941 N GLU C 118 -14.251 13.219 -35.561 1. 00 58.12 NATOM 3941 N GLU C 118 -14.251 13.219 -35.561 1. 00 58.12 N
ATOM 3942 CA GLU C 118 -14.942 12.011 - 35. 987 1. 00 57.75 CATOM 3942 CA GLU C 118 -14.942 12.011-35. 987 1. 00 57.75 C
ATOM 3943 CB GLU G 118 -14.801 11.826 - 37. 497 1. 00 59.97 CATOM 3943 CB GLU G 118 -14.801 11.826-37. 497 1. 00 59.97 C
ATOM 3944 CG GLU C 118 -16,036 11.214 - 38. 147 1. 00 62.52 CATOM 3944 CG GLU C 118 -16,036 11.214-38. 147 1. 00 62.52 C
ATOM 3945 CD GLU C 118 -17.108 12.249 -38. 438 1. 00 62.94 CATOM 3945 CD GLU C 118 -17.108 12.249 -38. 438 1. 00 62.94 C
ATOM 3946 0E1 GLU C 118 -16.869 13.447 -38. 164 1. 00 62.82 0ATOM 3946 0E1 GLU C 118 -16.869 13.447 -38. 164 1. 00 62.82 0
ATOM 3947 0E2 GLU C 118 -18.186 11.863 - 38. 943 1. 00 62.16 0ATOM 3947 0E2 GLU C 118 -18.186 11.863-38. 943 1. 00 62.16 0
ATOM 3948 C GLU C 118 -14.487 10.759 -35. 232 1. 00 55.52 CATOM 3948 C GLU C 118 -14.487 10.759 -35. 232 1. 00 55.52 C
ATOM 3949 0 GLU C 118 -15.200 10.302 -34. 339 1. 00 56.36 0ATOM 3949 0 GLU C 118 -15.200 10.302 -34. 339 1. 00 56.36 0
ATOM 3950 N PRO C 119 -13.314 10.168 -35. 567 1. 00 53.12 NATOM 3950 N PRO C 119 -13.314 10.168 -35. 567 1. 00 53.12 N
ATOM 3951 CD PRO C 119 - 12.618 9.600 -34. 398 1. 00 52.07 CATOM 3951 CD PRO C 119-12.618 9.600 -34. 398 1. 00 52.07 C
ATOM 3952 CA PRO C 119 -12.450 10.125 -36. 762 1. 00 48.45 CATOM 3952 CA PRO C 119 -12.450 10.125 -36.762 1. 00 48.45 C
ATOM 3953 CB PRO C 119 -11.162 9.480 - 36. 251 1. 00 50.16 CATOM 3953 CB PRO C 119 -11.162 9.480-36. 251 1. 00 50.16 C
ATOM 3954 CG PRO C 119 9.706 -34. 783 1. ,00 50.56 CATOM 3954 CG PRO C 119 9.706 -34. 783 1., 00 50.56 C
ATOM 3955 C PRO C 119 -13.060 9.315 -37. 913 1. ,00 44.31 CATOM 3955 C PRO C 119 -13.060 9.315 -37. 913 1., 00 44.31 C
ATOM 3956 0 PRO C 119 -14.009 8.560 -37. 716 1. ,00 43.27 0ATOM 3956 0 PRO C 119 -14.009 8.560 -37. 716 1., 00 43.27 0
ATOM 3957 N VAL C 120 -12.503 9.465 - 39. 110 1. ,00 40.49 NATOM 3957 N VAL C 120 -12.503 9.465-39. 110 1., 00 40.49 N
ATOM 3958 CA VAL c 120 -13.163 8.985 -40.326 1. .00 39.02 CATOM 3958 CA VAL c 120 -13.163 8.985 -40.326 1. .00 39.02 C
ATOM 3959 CB VAL c 120 -13.302 10.127 -41. 358 1. .00 39.32 CATOM 3959 CB VAL c 120 -13.302 10.127 -41. 358 1. .00 39.32 C
ATOM 3960 CG1 VAL c 120 -14.056 9.637 -42. 574 1. .00 38.96 CATOM 3960 CG1 VAL c 120 -14.056 9.637 -42. 574 1. .00 38.96 C
ATOM 3961 CG2 VAL c 120 -14.001 11.318 -40. 734 1. .00 40.64 CATOM 3961 CG2 VAL c 120 -14.001 11.318 -40. 734 1. .00 40.64 C
ATOM 3962 C VAL c 120 - 12.428 7.827 -41. 020 1, .00 36.70 CATOM 3962 C VAL c 120-12.428 7.827 -41. 020 1, .00 36.70 C
ATOM 3963 0 VAL c 120 -11.290 7.974 -41. 453 1, .00 35.65 0ATOM 3963 0 VAL c 120 -11.290 7.974 -41. 453 1, .00 35.65 0
ATOM 3964 N PRO c 121 -13.086 6.665 -41. 152 1, .00 35.27 NATOM 3964 N PRO c 121 -13.086 6.665 -41. 152 1, .00 35.27 N
ATOM 3965 CD PRO c 121 -14.377 6.315 -40. 532 1, .00 34.91 CATOM 3965 CD PRO c 121 -14.377 6.315 -40. 532 1, .00 34.91 C
ATOM 3966 CA PRO c 121 -12.559 5.562 -41. 966 1 .00 32.29 CATOM 3966 CA PRO c 121 -12.559 5.562 -41. 966 1 .00 32.29 C
ATOM 3967 CB PRO c 121 -13.424 4.378 -41. 558 1, .00 31.81 CATOM 3967 CB PRO c 121 -13.424 4.378 -41. 558 1, .00 31.81 C
ATOM 3968 CG PRO G 121 -14.726 4.998 -41. 187 1, .00 34.47 CATOM 3968 CG PRO G 121 -14.726 4.998 -41. 187 1, .00 34.47 C
ATOM 3969 C PRO c 121 -12.671 5.851 -43. 468 1, .00 30.58 CATOM 3969 C PRO c 121 -12.671 5.851 -43. 468 1, .00 30.58 C
ATOM 3970 0 PRO c 121 -13.663 6.411 -43. 931 1 .00 31.11 0ATOM 3970 0 PRO c 121 -13.663 6.411 -43. 931 1 .00 31.11 0
ATOM 3971 N TYR c 122 -11.658 5.462 -44. 230 1 • 00 28.08 N 621 ATOM 3971 N TYR c 122 -11.658 5.462 -44. 230 1 • 00 28.08 N 621
0 LL'Z 00· L OZL '99- 6½'l 898 ·8- 931 0 s人， αο LOOP W01V 0 LL'Z 00L OZL '99 -6½'l 898 8 931 0 s people, αο LOOP W01V
0 68 Ofr 00· I WL '9S- 69ε 'Ζ v -6- S3L 0 s人， 90 900fr W01V0 68 Ofr 00 · I WL '9S- 69ε' Ζ v -6- S3L 0 s, 90 900fr W01V
0 '6S 00' I SfrS S - 9ΐζτ 9S9 '8- 931 0 s人つ ao SOOfr W01V0 '6S 00' I SfrS S-9ΐζτ 9S9 '8- 931 0 s people ao SOOfr W01V
0 19'ζ.ε ΟΟ' I IZZ '89- ζζ6 'τ 02f '6 - 9ZI 0 SAT νο ΡΟΟ^ W01V0 19'ζ.ε ΟΟ 'I IZZ '89-ζζ6' τ 02f '6-9ZI 0 SAT νο ΡΟΟ ^ W01V
N 09'9ε 00 ' L Z.6'L9- Ζ.06 Ζ 899 ·8 - 931 0 s人， Ν SOOfr WOIVN 09'9ε 00 'L Z.6'L9- Ζ.06 Ζ 899 · 8-931 0 s, Ν SOOfr WOIV
0 LI■££ 00' L 882 '39- 986 S8 'ん - Zl 3 N1D 0 ΖΟΟ 1N01V0 LI ££ 00 'L 882 '39 -986 S8'-Zl 3 N1D 0 ΖΟΟ 1N01V
0 8fr ·εε 00 I 299'LS- 9ん 6 ·ε V66 'L - m 0 ΝΊ9 0 WO W01V0 8fr εε 00 I 299'LS-9 9 ε V66 'L-m 0 ΝΊ9 0 WO W01V
N 9S'9S 00' L 9SS '8 906 ' LZS — m 0 N19 Zョ N OOOfr W01VN 9S'9S 00 'L 9SS' 8 906 'LZS — m 0 N19 Zo N OOOfr W01V
0 39 ·8ε 00■ 1· βε I 09- 166 ,9 6.6 ·ε- Zl 0 ΝΊ9 130 6668 W01V0 39 8ε 00 ■ 1βε I 09- 166, 9 6.6ε- Zl 0 ΝΊ9 130 6668 W01V
0 L8.ん ε 00 L O'S 9 9 - Zl 0 ΝΊ9 αο 866Ε 1N01V0 L8. Ε 00 L O'S 9 9-Zl 0 ΝΊ9 αο 866Ε 1N01V
0 93 ' 00 Ί Z2 '09- ½8·ε 956 - m 0 N19 90 66ε W01V0 93 '00 Ί Z2 '09-½8 · ε 956-m 0 N19 90 66ε W01V
0 00' L 310 Ό9- ηι ε 902 ·9- 0 ΝΊ9 80 966ε 隱 V0 00 'L 310 Ό9- ηι ε 902 9- 0 ΝΊ9 80 966ε 隱 V
0 06 ZS 00 I 03 L OS - 196 ·ε ん 8fr 'L- m 0 N1D νο 566 W01V0 06 ZS 00 I 03 L OS-196 ε 8fr 'L- m 0 N1D νο 566 W01V
N 08 οε 00 l L6S ·ε C89 '8- 0 N19 Ν P66S W01VN 08 οε 00 l L6Sεε C89 '8- 0 N19 Ν P66S W01V
0 'οε 00 l ん OS '6fr— 1.8L '9 698 ·6 - ZZl 0 3Hd 0 S66S W01V0 'οε 00 l OS' 6fr— 1.8L '9 698 6-ZZl 0 3Hd 0 S66S W01V
0 90 "ΐε 00 Ί 9S I "6f- ζο 889 '6- £Zl 0 3Hd 0 3668 WOIV0 90 "ΐε 00 Ί 9S I" 6f- ζο 889 '6- £ Zl 0 3Hd 0 3668 WOIV
0 οι 'ζε 00 'I. 19Z '8fr - Ζ51 Ό- £Zl 0 3Hd ζο 166£ W01V0 οι 'ζε 00' I. 19Z '8fr-Ζ51 Ό- £ Zl 0 3Hd ζο 166 £ W01V
0 90 2 00 L 38ε "8fr- 9£1 'L UO'SL- SZl 0 3Hd 230 066 WOIV0 90 2 00 L 38ε "8fr- 9 £ 1 'L UO'SL- SZl 0 3Hd 230 066 WOIV
0 00 989 Ό- 09 'ει- ΖΖΪ 0 3Hd L30 686Ε WO丄 V0 00 989 09- 09 'ει- ΖΖΪ 0 3Hd L30 686Ε WO 丄 V
0 ε8 οε 00 'I Lし L -8fr- QU 'Ζ 9ん 0 Ή- Zl 0 3Hd 200 8868 W01V0 ε8 οε 00 'I L L -8fr- QU' Ζ 9 ん-Zl 0 3Hd 200 8868 W01V
0 00 'L 606 ·8ト δΟί-Ό ηνζι- ZZl 0 3Hd ιαο /.86 賺 V0 00 'L 606 8t δΟί-Ό ηνζι- ZZl 0 3Hd ιαο /.86 賺 V
0 9L 'οε 00 ■L 8tO "6fr- 6εζ.Ί τし L ζν- ZZl 0 3Hd DO 9868 1N01V0 9L 'οε 00 ■ L 8tO "6fr-6εζ.Ί τ L ζν- ZZl 0 3Hd DO 9868 1N01V
0 06 SZ 00 Ί 2½ '6fr - ILL U- Ul 0 3Hd ao 9869 隠 V0 06 SZ 00 Ί 2½ '6fr-ILL U- Ul 0 3Hd ao 9869 Hidden V
0 00 'I '8fr -. OH ·ε Ζ.08 '01 - ZZi 0 3Hd νο 86ε WO丄 V0 00 'I' 8fr-. OH · ε Ζ.08 '01-ZZi 0 3Hd νο 86ε WO 丄 V
N ΖΖ 6Ζ .00 ■L 329 'ん - 060 US'Ll- ZZY 〇 3Hd Ν' S86S 隠 VN ΖΖ 6Ζ .00 ■ L 329 'N-060 US'Ll- ZZY ○ 3Hd
0 L6'93 00 ■i S06 "Sfr- o - 9S6 "6- ZZl 0 y人丄 0 286ε IN01V0 L6'93 00 i S06 "Sfr-o-9S6" 6-ZZl 0 y People 0 286ε IN01V
0 t-9 '82 00 Ί 08S ·9 66 ZL6 'Ot - ZZl 0 y人丄 0 L86S WO上 V0 t-9 '82 00 Ί 08S 966 ZL6 'Ot-ZZl 0 y Human 0 L86S WO V
0 00 ■L 66 'η- 619 'Ζ. 99 '9- ZZl 0 Μλΐ ΗΟ 0868 W01V0 00 L 66 'η- 619' Ζ. 99 '9- ZZl 0 Μλΐ ΗΟ 0868 W01V
0 96 '83 00 -L vn 'st-- VL 986 "9- ZZl 0 y人丄 ζο 6 6ε IN01V0 96 '83 00 -L vn 'st-- VL 986 "9- ZZl 0 y people ζο 6 6ε IN01V
0 38 "92 00 Ί εο 600·ん IfS 'L - ZZl 0 iU丄 330 8 6ε W01V0 38 "92 00 ε εο 600 · IfS 'L-ZZl 0 iU 丄 330 8 6ε W01V
0 S9'LZ 00 Ί £ '9fr - LS8'9 L69 ·8- ZZl 0 Μλΐ ZQ LL6S WOiV0 S9'LZ 00 Ί £ '9fr-LS8'9 L69 8-ZZl 0 Μλΐ ZQ LL6S WOiV
0 61 6Ζ 00 'I 961 'η- ん S6 'L - ZZl 0 y人上 L30 9Ζ.68 匪 V0 61 6Ζ 00 'I 961' η- S6 'L-ZZl 0 y Person L30 9Ζ.68 匪 V
0 VZ '9Ζ 00 "I 119 'η- 99'L 683 '6- ZZl 0 y人丄 LGO sん 6ε IN01V0 VZ '9Ζ 00 "I 119' η-99'L 683 '6- ZZl 0 y Human LGO s 6ε IN01V
0 ZQ'LZ 00 'L ILL '9fr- ZZl 'L S89 '6- ZZl 0 y人丄 90 WOIV0 ZQ'LZ 00 'L ILL' 9fr- ZZl 'L S89' 6- ZZl 0 y People 90 WOIV
0 W92 00 ■L 90 L "9fr- tS6'9 03 L ·\Υ- ZZl 0 ϋ人丄 ao εζ,θε IN01V0 W92 00 L 90 L "9fr- tS6'9 03 L · \ Υ- ZZl 0 ϋ 人 丄 ao εζ, θε IN01V
0 18'LZ 00 ■L εζ.9 "Sfr- ん 09 'S LZL'U- ZZl 0 Μλΐ νο ZL62 WOIV 0 18'LZ 00 ■ L εζ.9 "Sfr-n 09 'S LZL'U- ZZl 0 Μλΐ νο ZL62 WOIV
SSLlL0/L00Zdr/13d SSLlL0 / L00Zdr / 13d
0C∑.S0/600Z OJX ATOM 4008 CE LYS C 125 -9.545 1.564 -58.082 1.0044.47 C0C∑.S0 / 600Z OJX ATOM 4008 CE LYS C 125 -9.545 1.564 -58.082 1.0044.47 C
ATOM 4009 NZ LYS c 125 -9.041 0.658 -59.155 1. 00 43.42 NATOM 4009 NZ LYS c 125 -9.041 0.658 -59.155 1. 00 43.42 N
ATOM 4010 C LYS c 125 -10.764 2.233 -53.028 1. 00 38.73 CATOM 4010 C LYS c 125 -10.764 2.233 -53.028 1. 00 38.73 C
ATOM 4011 0 LYS c 125 - 10.819 1.084 -52.596 1. 00 38.17 0ATOM 4011 0 LYS c 125-10.819 1.084 -52.596 1. 00 38.17 0
ATOM 4012 N LEU c 126 -11. 846 2.927 -53.362 1. 00 39.62 NATOM 4012 N LEU c 126 -11. 846 2.927 -53.362 1. 00 39.62 N
ATOM 4013 CA LEU c 126 -13.172 2.426 - 53.039 1. 00 42.71 CATOM 4013 CA LEU c 126 -13.172 2.426-53.039 1. 00 42.71 C
ATOM 4014 CB LEU c 126 -14.211 3.561 -53.137 1. 00 44.58 CATOM 4014 CB LEU c 126 -14.211 3.561 -53.137 1. 00 44.58 C
ATOM 4015 CG LEU c 126 -14.812 4.092 -54. 445 1. 00 47.25 CATOM 4015 CG LEU c 126 -14.812 4.092 -54. 445 1. 00 47.25 C
ATOM 4016 CD1 LEU c 126 -13.836 3.914 -55. 610 1. 00 49.72 CATOM 4016 CD1 LEU c 126 -13.836 3.914 -55. 610 1. 00 49.72 C
ATOM 4017 CD2 LEU c 126 -16.121 3.366 -54. 714 1. 00 47.87 cATOM 4017 CD2 LEU c 126 -16.121 3.366 -54. 714 1.00 47.87 c
ATOM 4018 C LEU c 126 -13.547 1.250 - 53. 934 1. 00 42.61 cATOM 4018 C LEU c 126 -13.547 1.250-53. 934 1. 00 42.61 c
ATOM 4019 ,0 LEU c 126 - 13.242 1.240 -55. 125 1. 00 42.48 0ATOM 4019, 0 LEU c 126-13.242 1.240 -55. 125 1. 00 42.48 0
ATOM 4020 N VAL c 127 - 14. 184 0.246 -53. 338 1. 00 43.18 ―ATOM 4020 N VAL c 127-14. 184 0.246 -53. 338 1. 00 43.18 ―
ATOM 4021 CA VAL c 127 -14. 549 -0.978 - 54. 045 1. 00 45.17 GATOM 4021 CA VAL c 127 -14. 549 -0.978-54. 045 1. 00 45.17 G
ATOM 4022 CB VAL c 127 -13. 475 -2.083 -53. 857 1. 00 46.21 CATOM 4022 CB VAL c 127 -13. 475 -2.083 -53. 857 1. 00 46.21 C
ATOM 4023 CG1 VAL c 127 -12. 193 -1.697 -54. 575 1. 00 45.37 CATOM 4023 CG1 VAL c 127 -12. 193 -1.697 -54. 575 1. 00 45.37 C
ATOM 4024 CG2 VAL c 127 -13. 205 -2.292 -52. 373 1. 00 45.17 CATOM 4024 CG2 VAL c 127 -13. 205 -2.292 -52. 373 1. 00 45.17 C
ATOM 4025 C VAL c 127 -15. 886 -1.520 -53. 539 1. ,00 46.19 CATOM 4025 C VAL c 127 -15. 886 -1.520 -53. 539 1., 00 46.19 C
ATOM 4026 0 VAL c 127 -16. 413 - 1.048 -52. 530 1. 00 48.24 o 0ATOM 4026 0 VAL c 127 -16. 413-1.048 -52. 530 1. 00 48.24 o 0
ATOM 4027 N SER c 128 -16. 434 -2.508 -54. 239 1. 00 45.77 NATOM 4027 N SER c 128 -16. 434 -2.508 -54. 239 1. 00 45.77 N
ATOM 4028 CA SER c 128 -17. 650 -3.168 - 53. 778 1. ,00 47.29 CATOM 4028 CA SER c 128 -17. 650 -3.168-53. 778 1., 00 47.29 C
ATOM 4029 CB SER c 128 -18. 596 -3.435 -54. 950 1. ,00 46.84 CATOM 4029 CB SER c 128 -18. 596 -3.435 -54. 950 1., 00 46.84 C
ATOM 4030 OG SER c 128 -18. 061 -4.427 -55.810 1. ,00 51.26 0ATOM 4030 OG SER c 128 -18. 061 -4.427 -55.810 1., 00 51.26 0
ATOM 4031 C SER c 128 -17. 315 -4.488 -53. 091 1. .00 46.15 CATOM 4031 C SER c 128 -17. 315 -4.488 -53. 091 1. .00 46.15 C
ATOM 4032 0 SER c 128 -16. 447 -5.232 -53. 547 1. .00 43.88 0ATOM 4032 0 SER c 128 -16. 447 -5.232 -53. 547 1. .00 43.88 0
ATOM 4033 N ASN c 129 -18. 015 -4.767 -51. 996 1. .00 46.24 NATOM 4033 N ASN c 129 -18. 015 -4.767 -51. 996 1. .00 46.24 N
ATOM 4034 CA ASN c 129 -17. 866 - 6.025 - 51. 278 1. .00 47.01 CATOM 4034 CA ASN c 129 -17. 866-6.025-51. 278 1. .00 47.01 C
ATOM 4035 CB ASN c 129 -17. 686 -5.766 -49. 782 1, .00 45.15 CATOM 4035 CB ASN c 129 -17. 686 -5.766 -49. 782 1, .00 45.15 C
ATOM 4036 CG ASN c 129 一 16. 515 -4.854 -49. 483 1. .00 44.91 CATOM 4036 CG ASN c 129 1 16. 515 -4.854 -49. 483 1. .00 44.91 C
ATOM 4037 0D1 ASN c 129 -15. 467 -4.933 -50. 126 1. .00 44.23 0ATOM 4037 0D1 ASN c 129 -15. 467 -4.933 -50. 126 1. .00 44.23 0
ATOM 4038 ND2 ASN c 129 -16. 688 -3.980 -48. 500 1, .00 45.41 NATOM 4038 ND2 ASN c 129 -16. 688 -3.980 -48. 500 1, .00 45.41 N
ATOM 4039 C ASN c 129 -19. 084 -6.918 -51. 480 1, .00 49.12 CATOM 4039 C ASN c 129 -19. 084 -6.918 -51. 480 1, .00 49.12 C
ATOM 4040 0 ASN c 129 -19. 366 -7.784 -50. 650 1 .00 51.00 0ATOM 4040 0 ASN c 129 -19. 366 -7.784 -50. 650 1 .00 51.00 0
ATOM 4041 N ILE c 130 -19. 814 -6.707 -52. 570 1 .00 49.98 NATOM 4041 N ILE c 130 -19. 814 -6.707 -52. 570 1 .00 49.98 N
ATOM 4042 CA ILE c 130 -21. 022 -7.490 -52. 823 1 .00 CATOM 4042 CA ILE c 130 -21. 022 -7.490 -52. 823 1 .00 C
ATOM 4043 CB ILE c 130 -21. 885 - 6.866 -53. 955 1 • 00 C ATOM 4044 CG2 ILE C 130 - 23.101 -7.744 - 54.227 1.00 50.07 CATOM 4043 CB ILE c 130 -21. 885-6.866 -53. 955 1 • 00 C ATOM 4044 CG2 ILE C 130-23.101 -7.744-54.227 1.00 50.07 C
ATOM 4045 GG1 ILE c 130 -22.344 -5.461 - 53.556 1. 00 52.53 CATOM 4045 GG1 ILE c 130 -22.344 -5.461-53.556 1. 00 52.53 C
ATOM 4046 CD1 ILE c 130 - 23.324 -5.441 -52.400 1. 00 53.13 CATOM 4046 CD1 ILE c 130-23.324 -5.441 -52.400 1. 00 53.13 C
ATOM 4047 C ILE c 130 - 20.693 - 8.937 -53.197 1. 00 50.40 CATOM 4047 C ILE c 130-20.693-8.937 -53.197 1. 00 50.40 C
ATOM 4048 0 ILE c 130 -21.397 -9.857 -52. 791 1. 00 51.03 0ATOM 4048 0 ILE c 130 -21.397 -9.857 -52. 791 1. 00 51.03 0
ATOM 4049 N ASP c 131 -19.622 -9.137 - 53. 964 1. 00 49.68 NATOM 4049 N ASP c 131 -19.622 -9.137-53. 964 1. 00 49.68 N
ATOM 4050 CA ASP c 131 -19.219 -10.484 -54. 375 1. 00 49.36 CATOM 4050 CA ASP c 131 -19.219 -10.484 -54. 375 1. 00 49.36 C
ATOM 4051 CB ASP c 131 -18.518 -10.446 -55. 744 1. 00 CATOM 4051 CB ASP c 131 -18.518 -10.446 -55. 744 1. 00 C
ATOM 4052 C6 ASP c 131 -19.381 - 9.820 -56. 836 1. 00 53.59 cATOM 4052 C6 ASP c 131 -19.381-9.820 -56. 836 1. 00 53.59 c
ATOM 4053 0D1 ASP c 131 -20.588 -10.141 -56. 918 1. 00 54.44 0ATOM 4053 0D1 ASP c 131 -20.588 -10.141 -56. 918 1. 00 54.44 0
ATOM 4054 0D2 ASP c 131 -18.847 -9.002 -57. 619 1. 00 54.26 0ATOM 4054 0D2 ASP c 131 -18.847 -9.002 -57. 619 1. 00 54.26 0
ATOM 4055 C ASP c 131 -18.280 -11.115 -53. 344 1. 00 47.70 GATOM 4055 C ASP c 131 -18.280 -11.115 -53. 344 1. 00 47.70 G
ATOM 4056 0 ASP c 131 -17.701 -12.173 -53. 578 1. 00 48.34 0ATOM 4056 0 ASP c 131 -17.701 -12.173 -53. 578 1. 00 48.34 0
ATOM 4057 N GLU c 132 -18.133 -10.456 - 52. 203 1. 00 45.31 NATOM 4057 N GLU c 132 -18.133 -10.456-52. 203 1. 00 45.31 N
ATOM 4058 CA GLU c 132 -17.164 -10.864 -51. 198 1. 00 43.68 CATOM 4058 CA GLU c 132 -17.164 -10.864 -51. 198 1. 00 43.68 C
ATOM 4059 CB GLU c 132 - 16.656 -9.622 -50. 468 1. 00 42.10 CATOM 4059 CB GLU c 132-16.656 -9.622 -50. 468 1. 00 42.10 C
ATOM 4060 CG GLU c 132 -15.959 -9.892 - 49. 160 1. 00 39.73 CATOM 4060 CG GLU c 132 -15.959 -9.892-49. 160 1. 00 39.73 C
ATOM 4061 CD GLU c 132 -15.837 - 8.636 -48. 324 1. ,00 40.15 CATOM 4061 CD GLU c 132 -15.837-8.636 -48. 324 1., 00 40.15 C
ATOM 4062 0E1 GLU c 132 -16.680 -8.445 -47. 419 1. .00 39.20o t 0ATOM 4062 0E1 GLU c 132 -16.680 -8.445 -47. 419 1. .00 39.20o t 0
ATOM 4063 0E2 GLU c 132 -14.904 -7.840 -48. 574 1. ,00 38.12 0ATOM 4063 0E2 GLU c 132 -14.904 -7.840 -48. 574 1., 00 38.12 0
ATOM 4064 C GLU c 132 -17.785 -11.838 - 50. 203 1. ,00 42.80 CATOM 4064 C GLU c 132 -17.785 -11.838-50. 203 1., 00 42.80 C
ATOM 4065 0 GLU c 132 -18.812 -11.542 -49. 607 1. ,00 44.48 0ATOM 4065 0 GLU c 132 -18.812 -11.542 -49. 607 1., 00 44.48 0
ATOM 4066 N ARG c 133 -17.163 - 12.995 -50.020 1. .00 NATOM 4066 N ARG c 133 -17.163-12.995 -50.020 1. .00 N
ATOM 4067 CA ARG c 133 -17.704 -14.003 -49. 114 1. .00 42.01 cATOM 4067 CA ARG c 133 -17.704 -14.003 -49. 114 1. .00 42.01 c
ATOM 4068 CB ARG c 133 -17.163 -15.392 - 49. 470 1, .00 45.71 cATOM 4068 CB ARG c 133 -17.163 -15.392-49. 470 1, .00 45.71 c
ATOM 4069 CG ARG c 133 -17.721 -15.964 - 50. 769 1. .00 cATOM 4069 CG ARG c 133 -17.721 -15.964-50. 769 1. .00 c
ATOM 4070 CD ARG c 133 -18.485 -17.268 -50. 541 1, .00 54.29 cATOM 4070 CD ARG c 133 -18.485 -17.268 -50. 541 1, .00 54.29 c
ATOM 4071 NE ARG c 133 -17.719 -18.442 -50. 956 1, .00 58.21 NATOM 4071 NE ARG c 133 -17.719 -18.442 -50. 956 1, .00 58.21 N
ATOM 4072 CZ ARG c 133 -18.181 -19.690 -50. 912 1 .00 60.24 cATOM 4072 CZ ARG c 133 -18.181 -19.690 -50. 912 1 .00 60.24 c
ATOM 4073 NH1 ARG c 133 -19.410 -19.928 -50. 468 1, .00 59.85 NATOM 4073 NH1 ARG c 133 -19.410 -19.928 -50. 468 1, .00 59.85 N
ATOM 4074 NH2 ARG c 133 -17.416 -20.699 - 51. 313 1, .00. 60.31 NATOM 4074 NH2 ARG c 133 -17.416 -20.699-51. 313 1, .00. 60.31 N
ATOM 4075 C ARG c 133 -17.378 -13.689 -47. 659 1 .00 40.23 CATOM 4075 C ARG c 133 -17.378 -13.689 -47. 659 1 .00 40.23 C
ATOM 4076 0 ARG c 133 -18.186 -13.928 -46. 765 1, .00 39.39 0ATOM 4076 0 ARG c 133 -18.186 -13.928 -46. 765 1, .00 39.39 0
ATOM 4077 N MET c 134 -16.187 - 13.156 - 47. 423 1 .00 38.08 NATOM 4077 N MET c 134 -16.187-13.156-47. 423 1 .00 38.08 N
ATOM 4078 CA MET c 134 -15.798 -12.767 -46. 076 1 .00 36.79 CATOM 4078 CA MET c 134 -15.798 -12.767 -46. 076 1 .00 36.79 C
ATOM 4079 CB MET c 134 -15.314 -13.979 -45. ,280 1 .00 38.38 C ATOM 4080 CG MET C 134 一 14.915 - 13.639 -43.859 1.0041.23 CATOM 4079 CB MET c 134 -15.314 -13.979 -45., 280 1 .00 38.38 C ATOM 4080 CG MET C 134 1 14.915-13.639 -43.859 1.0041.23 C
ATOM 4081 SD MET C 134 -14.380 -15.079 -42.933 1.0049.97 SATOM 4081 SD MET C 134 -14.380 -15.079 -42.933 1.0049.97 S
ATOM 4082 CE MET C 134 -13.450 -15.944 -44.192 1.0046.67 CATOM 4082 CE MET C 134 -13.450 -15.944 -44.192 1.0046.67 C
ATOM 4083 C MET C 134 - 14.702 -11.717 —46.091 1.0035.00 CATOM 4083 C MET C 134-14.702 -11.717 —46.091 1.0035.00 C
ATOM 4084 0 MET C 134 -13.872 -11.675 -47.002 1.00 34.91 0ATOM 4084 0 MET C 134 -13.872 -11.675 -47.002 1.00 34.91 0
ATOM 4085 N ALA C 135 -14.701 -10.877 -45.065 1.00 30.95 NATOM 4085 N ALA C 135 -14.701 -10.877 -45.065 1.00 30.95 N
ATOM 4086 CA ALA C 135 -13.689 - 9.852 -44.924 1.00 28.39 CATOM 4086 CA ALA C 135 -13.689-9.852 -44.924 1.00 28.39 C
ATOM 4087 CB ALA C 135 -14.338 -8.483 - 44.956 1.0025.94 CATOM 4087 CB ALA C 135 -14.338 -8.483-44.956 1.0025.94 C
ATOM 4088 C ALA C 135 - 12.980 -10.070 -43.600 1.00 28.09 CATOM 4088 C ALA C 135-12.980 -10.070 -43.600 1.00 28.09 C
ATOM 4089 0 ALA C 135 -13.628 -10.238 -42.568 1.00 30.20 0ATOM 4089 0 ALA C 135 -13.628 -10.238 -42.568 1.00 30.20 0
ATOM 4090 N LEU C 136 一 i 1.651 -10.077 - 43.634 1.00 25.68 NATOM 4090 N LEU C 136 i 1.651 -10.077-43.634 1.00 25.68 N
ATOM 4091 CA. LEU C 13€ - 10.858 -10.239 -42.427 1.00 24.79 CATOM 4091 CA. LEU C 13 €-10.858 -10.239 -42.427 1.00 24.79 C
ATOM 4092 CB LEU C 136 - 9.878 -11.408 -42.587 1.00 24.56 CATOM 4092 CB LEU C 136-9.878 -11.408 -42.587 1.00 24.56 C
ATOM 4093 CG LEU C 136 -10.446 -12.835 -42.527 1.00 28.70 CATOM 4093 CG LEU C 136 -10.446 -12.835 -42.527 1.00 28.70 C
ATOM 4094 CD1 LEU C 136 -11.722 -12.929 -43.342 1.00 29.04 CATOM 4094 CD1 LEU C 136 -11.722 -12.929 -43.342 1.00 29.04 C
ATOM 4095 CD2 LEU C 136 -9.420 -13.822 -43.062 1.00 26.67 CATOM 4095 CD2 LEU C 136 -9.420 -13.822 -43.062 1.00 26.67 C
ATOM 4096 C LEU C 136 -10.089 -8.950 -42.150 1.00 24.24 CATOM 4096 C LEU C 136 -10.089 -8.950 -42.150 1.00 24.24 C
ATOM 4097 0 LEU C 136 -9.014 -8.730 - 42.705 1.00 23.14 0ATOM 4097 0 LEU C 136 -9.014 -8.730-42.705 1.00 23.14 0
ATOM 4098 N ILE C 137 -10.639 -8.091 -41.302 1.00 22.55 NATOM 4098 N ILE C 137 -10.639 -8.091 -41.302 1.00 22.55 N
ATOM 4099 CA ILE C 137 - 9.954 -6.850 -41.011 1.00 23.48 CATOM 4099 CA ILE C 137-9.954 -6.850 -41.011 1.00 23.48 C
ATOM 4100 CB ILE C 137 -10.952 -5.697 -40.611 1.0024.13 CATOM 4100 CB ILE C 137 -10.952 -5.697 -40.611 1.0024.13 C
ATOM 4101 CG2 ILE c 137 -12.377 - 6.124 -40.828 1.00 23.20 CATOM 4101 CG2 ILE c 137 -12.377-6.124 -40.828 1.00 23.20 C
ATOM 4102 CG1 ILE c 137 -10.737 -5.274 -39.168 1.00 21.68 CATOM 4102 CG1 ILE c 137 -10.737 -5.274 -39.168 1.00 21.68 C
ATOM 4103 CD1 ILE c 137 - 9.535 -4.404 - 38.980 1.00 22.84 CATOM 4103 CD1 ILE c 137-9.535 -4.404-38.980 1.00 22.84 C
ATOM 4104 C ILE c 137 -8.935 -7.118 -39.904 1.00 23.01 CATOM 4104 C ILE c 137 -8.935 -7.118 -39.904 1.00 23.01 C
ATOM 4105 0 ILE c 137 -9.235 -7.760 -38.895 1.00 23.43 0ATOM 4105 0 ILE c 137 -9.235 -7.760 -38.895 1.00 23.43 0
ATOM 4106 N VAL c 138 -7.713 -6.650 -40.114 1.00 20.41 NATOM 4106 N VAL c 138 -7.713 -6.650 -40.114 1.00 20.41 N
ATOM 4107 CA VAL c 138 -6.645 - 6.962 -39.191 1.00 20.93 CATOM 4107 CA VAL c 138 -6.645-6.962 -39.191 1.00 20.93 C
ATOM 4108 CB VAL c 138 - 5.512 -7.776 - 39.884 1.00 20.83 CATOM 4108 CB VAL c 138-5.512 -7.776-39.884 1.00 20.83 C
ATOM 4109 C61 VAL c 138 - 6.076 -9.064 -40.451 1.00 19.07 CATOM 4109 C61 VAL c 138-6.076 -9.064 -40.451 1.00 19.07 C
ATOM 4110 CG2 VAL c 138 -4.873 -6.965 -40.982 1.00 16.89 CATOM 4110 CG2 VAL c 138 -4.873 -6.965 -40.982 1.00 16.89 C
ATOM 4111 C VAL c 138 -6.070 - 5.697 -38.596 1.00 21.63 CATOM 4111 C VAL c 138 -6.070-5.697 -38.596 1.00 21.63 C
ATOM 4112 0 VAL c 138 -5.821 -4.722 -39.297 1.00 23.10 0ATOM 4112 0 VAL c 138 -5.821 -4.722 -39.297 1.00 23.10 0
ATOM 4113 N ASP c 139 -5.872 -5.720 -37.290 1.0022.42 NATOM 4113 N ASP c 139 -5.872 -5.720 -37.290 1.0022.42 N
ATOM 4114 CA ASP c 139 -5.309 -4.589 -36,585 1.00 24.24 CATOM 4114 CA ASP c 139 -5.309 -4.589 -36,585 1.00 24.24 C
ATOM 4115 CB ASP c 139 -6.412 -3.553 -36.322 1.0027.11 C ATOM 4116 C6 ASP C 139 -5.860 -2.178 -36.006 1.00 30.99 CATOM 4115 CB ASP c 139 -6.412 -3.553 -36.322 1.0027.11 C ATOM 4116 C6 ASP C 139 -5.860 -2.178 -36.006 1.00 30.99 C
ATOM 4117 0D1 ASP C 139 -4.642 -1.969 -36. 205 1. 00 33.30 0ATOM 4117 0D1 ASP C 139 -4.642 -1.969 -36. 205 1.00 33.30 0
ATOM 4118 0D2 ASP C 139 -6.641 -1.307 -35. 560 1. 00 34.23 0ATOM 4118 0D2 ASP C 139 -6.641 -1.307 -35. 560 1. 00 34.23 0
ATOM 4119 C ASP C 139 - 4.738 -5.133 - 35. 271 1. 00 23.69 CATOM 4119 C ASP C 139-4.738 -5.133-35. 271 1. 00 23.69 C
ATOM 4120 0 ASP C 139 -5.395 - 5.878 -34.566 1. 00 25.94 0ATOM 4120 0 ASP C 139 -5.395-5.878 -34.566 1.00 25.94 0
ATOM 4121 N PRO C 1 0 -3.498 -4.774 -34.941 1. 00 22.97 NATOM 4121 N PRO C 1 0 -3.498 -4.774 -34.941 1. 00 22.97 N
ATOM 4122 CD PRO C 140 -2.573 -4.008 - 35.790 1. 00 22.29 CATOM 4122 CD PRO C 140 -2.573 -4.008-35.790 1.00 22.29 C
ATOM 4123 CA PRO C 140 -2.838 - 5.285 - 33.736 1. 00 24.30 CATOM 4123 CA PRO C 140 -2.838-5.285-33.736 1. 00 24.30 C
ATOM 4124 CB PRO C 140 -1.477 -4.601 -33.763 1. 00 22.57 CATOM 4124 CB PRO C 140 -1.477 -4.601 -33.763 1.00 22.57 C
ATOM 4125 CG PRO C 140 -1.237 - 4.357 - 35.216 1. 00 24.32 CATOM 4125 CG PRO C 140 -1.237-4.357-35.216 1. 00 24.32 C
ATOM 4126 C PRO C 140 -3.562 00 - 5.064 - 32.405 1. 00 26.62 CATOM 4126 C PRO C 140 -3.562 00-5.064-32.405 1.00 26.62 C
ATOM 4127 0 PRO C 140 -3.642 -5.980 -31: 582 1. 00 26.02 0ATOM 4127 0 PRO C 140 -3.642 -5.980 -31: 582 1. 00 26.02 0
ATOM 4128 N MET C 141 -4.078 - 3.859 00 -32.179 1. 00 26.48 NATOM 4128 N MET C 141 -4.078-3.859 00 -32.179 1.00 26.48 N
ATOM 4129 CA MET C 141 -4.605 -3.517 - 30. 862 1. 00 27.76 CATOM 4129 CA MET C 141 -4.605 -3.517-30. 862 1. 00 27.76 C
ATOM 4130 CB MET C 141 -3.686 - 2.500 -30. 195 1. 00 25.82 CATOM 4130 CB MET C 141 -3.686-2.500 -30. 195 1. 00 25.82 C
ATOM 4131 CG MET C 141 -2.267 -2.984 -30. 060 1. ,00 26.13 CATOM 4131 CG MET C 141 -2.267 -2.984 -30. 060 1., 00 26.13 C
ATOM 4132 SD MET C 141 -1.283 -1.884 -29. 054 1. 00 29.50 SATOM 4132 SD MET C 141 -1.283 -1.884 -29. 054 1. 00 29.50 S
ATOM 4133 CE MET C 141 -0.256 -29. 822 1. ,00 27.22 CATOM 4133 CE MET C 141 -0.256 -29. 822 1., 00 27.22 C
ATOM 4134 C MET C 141 -6.034 -2.982 -30. 879 1. .00 27.58 CATOM 4134 C MET C 141 -6.034 -2.982 -30. 879 1. .00 27.58 C
ATOM 4135 0 MET C 141 -6.319 -1.971 -31. 507 1. .00 30.56 0ATOM 4135 0 MET C 141 -6.319 -1.971 -31. 507 1. .00 30.56 0
ATOM 4136 N LEU C 142 -6.922 -3.670 -30. 177 1. .00 27.80 NATOM 4136 N LEU C 142 -6.922 -3.670 -30. 177 1. .00 27.80 N
ATOM 4137 CA LEU C 142 -8.308 - 3.242 -30. 029 1. .00 27.58 CATOM 4137 CA LEU C 142 -8.308-3.242 -30. 029 1. .00 27.58 C
ATOM 4138 CB LEU C 142 -9.232 -4.442 -30. 220 1. .00 28.95 CATOM 4138 CB LEU C 142 -9.232 -4.442 -30. 220 1. .00 28.95 C
ATOM 4139 CG LEU C 142 -10.728 -4.228 -30. 432 1. .00 29.33 CATOM 4139 CG LEU C 142 -10.728 -4.228 -30. 432 1. .00 29.33 C
ATOM 4140 CD1 LEU C 142 -10.970 -3.709 - 31. 834 1, .00 31.16 CATOM 4140 CD1 LEU C 142 -10.970 -3.709-31. 834 1, .00 31.16 C
ATOM 4141 CD2 LEU c 142 -11.465 -5.558 - 30. 247 1, .00 31.53 CATOM 4141 CD2 LEU c 142 -11.465 -5.558-30. 247 1, .00 31.53 C
ATOM 4142 C LEU c 1 2 -8.482 -2.674 - 28. 618 1 .00 26.62 CATOM 4142 C LEU c 1 2 -8.482 -2.674-28. 618 1 .00 26.62 C
ATOM 4143 0 LEU c 142 -8.820 -3.404 - 27. 690 1, .00 24.00 0ATOM 4143 0 LEU c 142 -8.820 -3.404-27. 690 1, .00 24.00 0
ATOM 4144 N ALA c 143 -8.237 -1.376 -28. 464 1 .00 26.16 NATOM 4144 N ALA c 143 -8.237 -1.376 -28. 464 1 .00 26.16 N
ATOM 4145 CA ALA c 143 -8.264 -0.735 - 27. 155 1 • 00 28.25 CATOM 4145 CA ALA c 143 -8.264 -0.735-27. 155 1 • 00 28.25 C
ATOM 4146 CB ALA c 143 -7.272 0.433 -27. 117 1 ■ 00 27.47 CATOM 4146 CB ALA c 143 -7.272 0.433 -27. 117 1 ■ 00 27.47 C
ATOM 4147 C ALA c 143 -9.666 -0.249 -26. 816 1 • 00 28.96 CATOM 4147 C ALA c 143 -9.666 -0.249 -26. 816 1 • 00 28.96 C
ATOM 4148 0 ALA c 143 - 10.276 -0.725 - 25. 858 1 .00 30.83 0ATOM 4148 0 ALA c 143-10.276 -0.725-25. 858 1 .00 30.83 0
ATOM 4149 N THR c 144 -10.188 0.682 -27. 606 1 .00 29.60 NATOM 4149 N THR c 144 -10.188 0.682 -27. 606 1 .00 29.60 N
ATOM 4150 CA THR G 144 -11.552 -27. 397 1 .00 29.17 CATOM 4150 CA THR G 144 -11.552 -27. 397 1 .00 29.17 C
ATOM 4151 GB THR c 144 -11.644 2.687 -27. 532 1 .00 29.83 C ffj ATOM 4151 GB THR c 144 -11.644 2.687 -27. 532 1 .00 29.83 C ffj
0 π 'ττ οο· ι 989 ん ε- 369 ·ε SZ6 ' — 09 L 0 V1V so W01V 0 π 'ττ οο · ι 989 ε- 369 · ε SZ6' — 09 L 0 V1V so W01V
0 んん ζ οο· L 698 ζ.ε- S9 'τ 8L8"9l- 09 L 0 V1V vo 98 W01V0 ζ οο · L 698 ζ.ε- S9 'τ 8L8 "9l- 09 L 0 V1V vo 98 W01V
N 9 τζ οο■ ι ZSL ■9ε - SS9 ΈΙ.- 09 L 0 V1V N 98l.fr W01VN 9 τζ οο ■ ι ZSL ■ 9ε-SS9 ΈΙ.- 09 L 0 V1V N 98l.fr W01V
0 63 001 ι ■/.ε- 06 L Ό LOZ -LI- 6f L 0 311 0 8 W01V0 63 00 1 ι / .ε- 06 L Ό LOZ -LI- 6f L 0 311 0 8 W01V
0 9L ' Ζ 00' L Ζ.89 ■9ε- 1 9 ·0 00 9L - 6frL 0 an 0 WOiV0 9L 'Ζ 00' L Ζ.89 9ε- 1 9 0 00 9L-6frL 0 an 0 WOiV
0 38 οε ΌΟ■ '1· S99 οεζ .ο - 90 L -Z.L- 6t-L 3 311 Lao WOIV0 38 οε ΌΟ ■ '1 · S99 οεζ .ο-90 L -Z.L- 6t-L 3 311 Lao WOIV
0 00' ι 966 ζζ- 818 Ό - 989 9L- 6frL 0 311 LDD L8 WOIV0 00 'ι 966 ζζ- 818 Ό-989 9L- 6frL 0 311 LDD L8 WOIV
0 63 '92 00' L 36ε ε- 9EL 0 690 '8 L- 617 L 0 311 390 08 WOIV0 63 '92 00 'L 36ε ε- 9EL 0 690' 8 L- 617 L 0 311 390 08 WOIV
0 . SZ οο■ ι 9ΖΙ νε- ΡΟΖ 0 999 '9L- 6PI 0 311 90 6Z.Lt- WOIV0 .SZ οο ■ ι 9ΖΙ νε- ΡΟΖ 0 999 '9L- 6PI 0 311 90 6Z.Lt- WOIV
0 63 3 00■ L 96ε θε- L£ .0- 860 -91- 6frL 0 311 VO 8ん WOIV0 63 3 00 L 96ε θε- L £ .0- 860 -91- 6frL 0 311 VO 8
N 80 ' 2 00■ L L93 "9ε- L69 Ό- εζ.9 ' l- 6 I 0 311 . N LLl^ WOIVN 80 '2 00 ■ L L93 "9ε- L69 Ό- εζ.9' l- 6 I 0 311. N LLl ^ WOIV
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0 ん 9 £Ζ 00 L 0Ζ "9ε- 911 τ- 80801- 0 IVA ZOO LW WOIV0 9 £ Ζ 00 L 0Ζ "9ε- 911 τ-80801- 0 IVA ZOO LW WOIV
0 66 00' ι 6S9 ss- PSL ·ε- 8 0 IVA LDO SLIP WOIV0 66 00 'ι 6S9 ss- PSL ε- 8 0 IVA LDO SLIP WOIV
0 LS Z 00 ι ^60 ■SS - 9S9 'Ζ- Ζ.93 'ΖΙ- 8 0 IVA ao ZLI WOIV0 LS Z 00 ι ^ 60 SS-9S9 'Ζ- Ζ.93' ΖΙ- 8 0 IVA ao ZLI WOIV
0 98'83 00 V ん 86 ■ss- εん ε■ L - ZL 'Zl- Q l 0 IVA vo ILIV WOIV0 98'83 00 V 86 ss-ε ε ■ L-ZL 'Zl- Q l 0 IVA vo ILIV WOIV
N 66 'τι 00 ι 9ζ.ε '9ε- L81 Ό- 688' - 8 0 IVA N OLl WOIVN 66 'τι 00 ι 9ζ.ε' 9ε- L81 Ό-688 '-8 0 IVA N OLl WOIV
0 6 '£Ζ 00 Ί 613 'ん ε- 990 Ί 291 τι- 〇 yas 0 69 WOIV0 6 '£ Ζ 00 613 613' ε- 990 291 τι- 〇 yas 0 69 WOIV
0 61 'ττ 00 Ί S90 "9ε- 6^6.0 09 ' - m 0 Mas 0 89 WOIV0 61 'ττ 00 Ί S90 "9ε- 6 ^ 6.0 09'-m 0 Mas 0 89 WOIV
0 11 93 00 ■ι 689 ε- PL6 Ζ Κ6 "8- 0 M3S 90 L9l^ INOiV0 11 93 00 ιι 689 ε- PL6 Ζ Κ6 "8- 0 M3S 90 L9l ^ INOiV
0 S8.LZ 00 ■L Ζ.82 s - 968 "1 989 '6- 0 «3S ao 991V WOIV0 S8.LZ 00 ■ L Ζ.82 s-968 "1 989 '6- 0« 3S ao 991V WOIV
0 91 ΖΖ 00 εοε "9ε- ζζι Ζ 960 ' I L- 0 vo 99lfr WOIV0 91 ΖΖ 00 εοε "9ε- ζζι Ζ 960 'I L- 0 vo 99lfr WOIV
N 3ο ζ 00 Ί o VZZ Z L l 0 yョ s N 9lt WOIVN 3ο ζ 00 Ί o VZZ Z L l 0 y s N 9lt WOIV
0 98'9Ζ 00 Ί ε- 9ZL 9 I 0人つ 9 0' S9 WOIV0 98'9Ζ 00 Ί ε- 9ZL 9 I 0 people 9 0 'S9 WOIV
〇 Li ' Z 00 Η ΖΖ8 •εε - 'τ 016 -ΖΪ- 9frL 0 AID 0 Z9i WOIV〇 Li 'Z 00 Η ΖΖ8εε-' τ 016 -ΖΪ- 9frL 0 AID 0 Z9i WOIV
0 16 ΈΖ 00 Ί ん 8ε 'Ζ£- Ζ88 Ζ 9εε ·εト 9frl 0人" 19 vo 191 WOIV0 16 ΈΖ 00 Ί 8ε 'Ζ £-Ζ88 Ζ 9εε · εt 9frl 0 ”19 vo 191 WOIV
N 96 ZZ 00 Ί 'ΐ.ε- 6WL εοθ -ζι- 9 I 0 AID N 09 WOIVN 96 ZZ 00 Ί 'ΐ.ε-6 WL εοθ -ζι- 9 I 0 AID N 09 WOIV
0 9802 00 Ί 889 ■ζε- U3O ζη ·ει- 9frL 0 AID 0 6S INOIV0 9802 00 Ί 889 ζε- U3O ζη · ει- 9frL 0 AID 0 6S INOIV
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0 QL ZZ 00 'L 909 'οε— LLfr Ό- 9S8 ζι- St L 0 人， 9 o WOIV0 QL ZZ 00 'L 909' οε— LLfr 9- 9S8 ζι- St L 0 people, 9 o WOIV
N WS3 00 ■!■ 2Ζ.9 62- ZLI Ό 666 ' L L- 9frL 0人 Ί9 N 951V WOIVN WS3 00 ■! ■ 2Ζ.9 62- ZLI 666 666 'L L- 9frL 0 people Ί 9 N 951V WOIV
0 8S '82 00 ·!■ L01 ,8 - 08C Ό 869 ·ε卜 PVl 0 mi 0 SSL WOIV0 8S '82 00 ·! ■ L01, 8-08C Ό869 ε 卜 PVl 0 mi 0 SSL WOIV
0 00 ■L L6S ,83 - εε9 ο S'ZL— nv 0 i 0 ½L17 WOIV0 00 L L6S, 83-εε9 ο S'ZL— nv 0 i 0 ½L17 WOIV
0 ιζ ·οε 00 Η L19 93- 9^9 ΌΙ- m 0 mi 390 INOiV0 ιζ οε 00 Η L19 93- 9 ^ 9 ΌΙ- m 0 mi 390 INOiV
0 ζο ,ζε 00 Ί 088 '82- 990 'ε ½ε ' — 0 mi L90 Z lf WOIV 0 ζο, ζε 00 Ί 088 '82-990 'ε ½ε' — 0 mi L90 Z lf WOIV
SSZ,T.0/.00Zdf/X3d TJP2007/071755 SSZ, T.0 / .00Zdf / X3d TJP2007 / 071755
ATOM 4188 C ALA C 150 -15.503 1.782 -39.189 1. 00 24.99 CATOM 4188 C ALA C 150 -15.503 1.782 -39.189 1.00 24.99 C
ATOM 4189 0 ALA C 150 -16.195 1.999 - 40.188 1. 00 25.69 0ATOM 4189 0 ALA C 150 -16.195 1.999-40.188 1.00 25.69 0
ATOM 4190 N THR C 151 -14.467 0.946 -39.197 1. 00 24.96 NATOM 4190 N THR C 151 -14.467 0.946 -39.197 1. 00 24.96 N
ATOM 4191 CA THR C 151 -14.097 0.203 -40.400 1. 00 24.49 CATOM 4191 CA THR C 151 -14.097 0.203 -40.400 1.00 24.49 C
ATOM 4192 CB THR C 151 -12.809 -0.637 -40.163 1. 00 25.27 CATOM 4192 CB THR C 151 -12.809 -0.637 -40.163 1. 00 25.27 C
ATOM 4193 061 THR C 151 -11.733 0.237 -39.802 1. 00 23.26 0ATOM 4193 061 THR C 151 -11.733 0.237 -39.802 1.00 23.26 0
ATOM 4194 C62 THR C 151 -12.418 -1.409 -41.421 1. 00 22.15 CATOM 4194 C62 THR C 151 -12.418 -1.409 -41.421 1. 00 22.15 C
ATOM 4195 C THR C 151 -15.237 -0.722 -40.819 1. 00 24.87 CATOM 4195 C THR C 151 -15.237 -0.722 -40.819 1.00 24.87 C
ATOM 4196 0 THR C 151 - 15.600 -0.791 -41.997 1. 00 23.81 0ATOM 4196 0 THR C 151-15.600 -0.791 -41.997 1.00 23.81 0
ATOM 4197 N ILE C 152 -15.812 -1 · 427 -39.852 1. 00 26.51 NATOM 4197 N ILE C 152 -15.812 -1 427 -39.852 1. 00 26.51 N
ATOM 4198 CA ILE C 152 -16.904 -2.338 - 40.158 1. 00 28.01 CATOM 4198 CA ILE C 152 -16.904 -2.338-40.158 1. 00 28.01 C
ATOM 4199 CB ILE C 152 -17.408 - 3, 051 -38.890 1. 00 27.73 CATOM 4199 CB ILE C 152 -17.408-3, 051 -38.890 1. 00 27.73 C
ATOM 4200 CG2 ILE C 152 -18.597 -3.938 -39.226 1. 00 25.32 CATOM 4200 CG2 ILE C 152 -18.597 -3.938 -39.226 1. 00 25.32 C
ATOM 4201 C61 ILE C 152 -16.276 -3.881 -38.283 1. 00 25.75 CATOM 4201 C61 ILE C 152 -16.276 -3.881 -38.283 1. 00 25.75 C
ATOM 4202 CD1 ILE C 152 -16.686 -4.669 -37.075 1. 00 24.74 CATOM 4202 CD1 ILE C 152 -16.686 -4.669 -37.075 1. 00 24.74 C
ATOM 4203 C ILE C 152 -18.064 -1.583 - 40.807 1. 00 30.66 CATOM 4203 C ILE C 152 -18.064 -1.583-40.807 1.00 30.66 C
ATOM 4204 0 ILE C 152 -18.641 -2.054 -41.797 1. 00 31.92 0ATOM 4204 0 ILE C 152 -18.641 -2.054 -41.797 1.00 31.92 0
ATOM 4205 N ASP C 153 - 18.394 -0.411 -40.262 1. 00 29.43 NATOM 4205 N ASP C 153-18.394 -0.411 -40.262 1. 00 29.43 N
ATOM 4206 CA ASP c 153 -19.441 0.422 -40.846 1. 00 30.45 CATOM 4206 CA ASP c 153 -19.441 0.422 -40.846 1. 00 30.45 C
ATOM 4207 CB ASP c 153 -19.574 1.739 -40.075 1. ,00 32.68 CATOM 4207 CB ASP c 153 -19.574 1.739 -40.075 1., 00 32.68 C
ATOM 4208 CG ASP c 153 -20.113 1.546 -38.659 1. ,00 33.86 CATOM 4208 CG ASP c 153 -20.113 1.546 -38.659 1., 00 33.86 C
ATOM 4209 0D1 ASP c 153 -20.948 0.638 -38.456 1. ,00 34.99 0ATOM 4209 0D1 ASP c 153 -20.948 0.638 -38.456 1., 00 34.99 0
ATOM 4210 0D2 ASP c 153 -t9.703 2.305 -37.752 1. ,00 32.67 0ATOM 4210 0D2 ASP c 153 -t9.703 2.305 -37.752 1., 00 32.67 0
ATOM 4211 C ASP G 153 -19.087 0.709 -42.298 1. ,00 30.78 CATOM 4211 C ASP G 153 -19.087 0.709 -42.298 1., 00 30.78 C
ATOM 4212 0 ASP C 153 -19.928 0.604 -43. '191 1. ,00 32.60 0ATOM 4212 0 ASP C 153 -19.928 0.604 -43. '191 1., 00 32.60 0
ATOM 4213 N LEU C 154 -17.826 1.056 -42.526 1. ,00 30.34 NATOM 4213 N LEU C 154 -17.826 1.056 -42.526 1., 00 30.34 N
ATOM 4214 CA LEU C 154 -17.318 1.280 - 43.873 1. .00 28.37 CATOM 4214 CA LEU C 154 -17.318 1.280-43.873 1. .00 28.37 C
ATOM 4215 CB LEU c 154 -15.827 1.617 -43.804 1, .00 27.90 CATOM 4215 CB LEU c 154 -15.827 1.617 -43.804 1, .00 27.90 C
ATOM 4216 C6 LEU c 154 -15.184 2.566 -44.820 1, .00 28.84 CATOM 4216 C6 LEU c 154 -15.184 2.566 -44.820 1, .00 28.84 C
ATOM 4217 CD1 LEU c 154 -13.901 1.939 -45.348 1, .00 26.13 CATOM 4217 CD1 LEU c 154 -13.901 1.939 -45.348 1, .00 26.13 C
ATOM 4218 CD2 LEU e 154 -16.144 2.870 -45.949 1, .00. 28.01 CATOM 4218 CD2 LEU e 154 -16.144 2.870 -45.949 1, .00. 28.01 C
ATOM 4219 C LEU c 154 -17.537 0.041 -44.745 1, .00 27.83 CATOM 4219 C LEU c 154 -17.537 0.041 -44.745 1, .00 27.83 C
ATOM 4220 0 LEU c 154 -18.078 0.139 - 45.847 1, .00 27.60 0ATOM 4220 0 LEU c 154 -18.078 0.139-45.847 1, .00 27.60 0
ATOM 4221 N LEU c 155 -17.120 - 1.126 -44.255 1, .00 27.97 NATOM 4221 N LEU c 155 -17.120-1.126 -44.255 1, .00 27.97 N
ATOM 4222 CA LEU c 155 -17.253 -2.362 -45.034 1, .00 27.53 CATOM 4222 CA LEU c 155 -17.253 -2.362 -45.034 1, .00 27.53 C
ATOM 4223 CB LEU c 155 -16.499 -3.516 -44.370 1 .00 25.95 C ATOM 4224 CG LEU C 155 -14.982 -3.427 -44.212 1.00 27.67 CATOM 4223 CB LEU c 155 -16.499 -3.516 -44.370 1 .00 25.95 C ATOM 4224 CG LEU C 155 -14.982 -3.427 -44.212 1.00 27.67 C
ATOM 4225 CD1 LEU C 155 - 14.466 -4.764 -43.684 1. 00 23. 55 CATOM 4225 CD1 LEU C 155-14.466 -4.764 -43.684 1. 00 23. 55 C
ATOM 4226 CD2 LEU C 155 -14.329 -3.074 -45.537 1. 00 27. 09 CATOM 4226 CD2 LEU C 155 -14.329 -3.074 -45.537 1. 00 27. 09 C
ATOM 4227 C LEU C 155 -18.714 -2.782 -45.232 1. 00 28. 03 CATOM 4227 C LEU C 155 -18.714 -2.782 -45.232 1. 00 28. 03 C
ATOM 4228 0 LEU C 155 -19.087 -3.243 -46.302 1. 00 26. 77 0ATOM 4228 0 LEU C 155 -19.087 -3.243 -46.302 1. 00 26. 77 0
ATOM 4229 N LYS C 156 -19.535 -2.630 -44.197 1. 00 28. 95 NATOM 4229 N LYS C 156 -19.535 -2.630 -44.197 1. 00 28. 95 N
ATOM 4230 CA LYS C 156 -20.949 -2.961 -44.312 1. 00 31. 09 GATOM 4230 CA LYS C 156 -20.949 -2.961 -44.312 1. 00 31. 09 G
ATOM 4231 CB LYS C 156 -21.650 - 2.834 -42.957 1. 00 30. 59 CATOM 4231 CB LYS C 156 -21.650-2.834 -42.957 1. 00 30. 59 C
ATOM 4232 CG LYS C 156 - 21.537 -4.073 -42.097 1. 00 31. 28 CATOM 4232 CG LYS C 156-21.537 -4.073 -42.097 1. 00 31. 28 C
ATOM 4233 CD LYS C 156 - 22.282 -3.923 -40.783 1. 00 34. 45 CATOM 4233 CD LYS C 156-22.282 -3.923 -40.783 1.00 34. 45 C
ATOM 4234 CE LYS C 156 -22.305 -5.247 -40.018 1. 00 37. 05 CATOM 4234 CE LYS C 156 -22.305 -5.247 -40.018 1.00 37. 05 C
ATOM 4235 NZ LYS C 156 - 22.574 -5.045 -38.562 1. 00 37. 19 NATOM 4235 NZ LYS C 156-22.574 -5.045 -38.562 1. 00 37. 19 N
ATOM 4236 C LYS C 156 -2.077 -45.329 1. 00 32. 72 CATOM 4236 C LYS C 156 -2.077 -45.329 1. 00 32. 72 C
ATOM 4237 0 LYS C 156 -22.532 -2.544 -46.053 1. 00 33. 72 0ATOM 4237 0 LYS C 156 -22.532 -2.544 -46.053 1.00 33. 72 0
ATOM 4238 N ALA C 157 -21.274 - 0.804 -45.386 1. 00 33. 79 NATOM 4238 N ALA C 157 -21.274-0.804 -45.386 1. 00 33. 79 N
ATOM 4239 CA ALA C 157 -21.887 0.112 -46.339 1. 00 34.60 CATOM 4239 CA ALA C 157 -21.887 0.112 -46.339 1. 00 34.60 C
ATOM 4240 CB ALA C 157 - 21.424 1.544 -46.076 1. ,00 35. 65 CATOM 4240 CB ALA C 157-21.424 1.544 -46.076 1., 00 35. 65 C
ATOM 4241 C ALA C 157 -21.511 -0.315 -47.749 1. ,00 36. 68 CATOM 4241 C ALA C 157 -21.511 -0.315 -47.749 1., 00 36.68 C
ATOM 4242 0 ALA C 157 - 22.331 -0.249 -48.672 1, ,00 .38. 40 0ATOM 4242 0 ALA C 157-22.331 -0.249 -48.672 1,, 00 .38. 40 0
ATOM 4243 N ALA C 158 -20.275 -0.777 -47.910 1. .00 35. 31 NATOM 4243 N ALA C 158 -20.275 -0.777 -47.910 1. .00 35. 31 N
ATOM 4244 CA ALA C 158 -19.770 -1.140 -49.227 1. .00 34. 58 CATOM 4244 CA ALA C 158 -19.770 -1.140 -49.227 1. .00 34. 58 C
ATOM 4245 CB ALA C 158 - 18.247 -1.191 -49.208 1. .00 34. 51 CATOM 4245 CB ALA C 158-18.247 -1.191 -49.208 1. .00 34. 51 C
ATOM 4246 C ALA C 158 - 20.335 - 2.478 -49.693 1. .00 34. 63 CATOM 4246 C ALA C 158-20.335-2.478 -49.693 1. .00 34. 63 C
ATOM 4247 0 ALA C 158 -20.107 -2.889 - 50.832 1. .00 34. 34 0ATOM 4247 0 ALA C 158 -20.107 -2.889-50.832 1. .00 34. 34 0
ATOM 4248 N GLY c 159 -21.062 -3.160 -48.813 1. .00 33. 83 NATOM 4248 N GLY c 159 -21.062 -3.160 -48.813 1. .00 33. 83 N
ATOM 4249 CA 6LY c 159 -21.714 - 4.397 -49.210 1, .00 33. 89 CATOM 4249 CA 6LY c 159 -21.714-4.397 -49.210 1, .00 33. 89 C
ATOM 4250 C GLY c 159 - 21.230 - 5.663 -48.524 1, .00 34. 91 CATOM 4250 C GLY c 159-21.230-5.663 -48.524 1, .00 34. 91 C
ATOM 4251 0 GLY c 159 -21.758 -6.746 -48.790 1, .00 33. 72 0ATOM 4251 0 GLY c 159 -21.758 -6.746 -48.790 1, .00 33. 72 0
ATOM 4252 N SER c 160 - 20.236 -5.544 -47.645 1, .00 34. 67 NATOM 4252 N SER c 160-20.236 -5.544 -47.645 1, .00 34. 67 N
ATOM 4253 CA SER c 160 - 19.747 -6.702 -46.900 1, .00 37. 19 CATOM 4253 CA SER c 160-19.747 -6.702 -46.900 1, .00 37. 19 C
ATOM 4254 CB SER c 160 - 18.642 -6.292 -45.917 1, .00 38. 78 CATOM 4254 CB SER c 160-18.642 -6.292 -45.917 1, .00 38. 78 C
ATOM 4255 OG SER c 160 -17.390 -6.155 -46.571 1, .00 40. 76 0ATOM 4255 OG SER c 160 -17.390 -6.155 -46.571 1, .00 40. 76 0
ATOM 4256 C SER c 160 -20.887 -7.359 - 46.127 1 .00 37. 18 CATOM 4256 C SER c 160 -20.887 -7.359-46.127 1 .00 37. 18 C
ATOM 4257 0 SER c 160 -21.778 -6.674 - 45.625 1 .00 37. ,48 0ATOM 4257 0 SER c 160 -21.778 -6.674-45.625 1 .00 37., 48 0
ATOM 4258 N SER c 161 - 20.850 -8.683 - 46.025 1 .00 36. ,30 NATOM 4258 N SER c 161-20.850 -8.683-46.025 1 .00 36., 30 N
ATOM 4259 CA SER c 161 -21.909 -9.419 -45.339 1 ■ 00 36. ,85 C ATOM 4260 CB SER C 161 - 22.689 -10.250 -46.351 1.00 36.08 CATOM 4259 CA SER c 161 -21.909 -9.419 -45.339 1 ∎ 00 36., 85 C ATOM 4260 CB SER C 161-22.689 -10.250 -46.351 1.00 36.08 C
ATOM 4261 OG SE C 61 -21.852 -11.222 -46.945 1. 00 36. 39 0ATOM 4261 OG SE C 61 -21.852 -11.222 -46.945 1. 00 36. 39 0
ATOM 4262 C SER G 161 - 21.383 -10.328 -44.221 1. 00 37. 77 CATOM 4262 C SER G 161-21.383 -10.328 -44.221 1. 00 37. 77 C
ATOM 4263 0 SER C 161 -22.051 -10.533 -43.202 1. 00 38. 81 0ATOM 4263 0 SER C 161 -22.051 -10.533 -43.202 1. 00 38. 81 0
ATOM 4264 N SER C 162 -20.195 -10.886 -44. 416 1. 00 35. 74 NATOM 4264 N SER C 162 -20.195 -10.886 -44. 416 1. 00 35. 74 N
ATOM 4265 CA SER C 162 -19.551 - 11.654 -43. 361 1. 00 33. 37 CATOM 4265 CA SER C 162 -19.551-11.654 -43. 361 1. 00 33. 37 C
ATOM 4266 CB SER C 162 -19.441 -13.126 - 43. 763 1. 00 35. 11 CATOM 4266 CB SER C 162 -19.441 -13.126-43. 763 1. 00 35. 11 C
ATOM 4267 06 SER C 162 -18.797 -13.885 -42. 751 1. 00 38. 27 0ATOM 4267 06 SER C 162 -18.797 -13.885 -42. 751 1. 00 38. 27 0
ATOM 4268 C SER C 162 -18.167 -11.086 -43. 061 1. 00 31. 82 CATOM 4268 C SER C 162 -18.167 -11.086 -43. 061 1. 00 31. 82 C
ATOM 4269 0 SER G 162 -17.324 -10.953 -43. 955 1. 00 31. 65 0ATOM 4269 0 SER G 162 -17.324 -10.953 -43. 955 1. 00 31. 65 0
ATOM 4270 N ILE C 163 -17.946 -10.757 -41. 794 1. 00 28. 08 NATOM 4270 N ILE C 163 -17.946 -10.757 -41. 794 1. 00 28. 08 N
ATOM 4271 CA ILE C 163 -16.787 - 9.983 -41. 390 1. 00 26. 00 CATOM 4271 CA ILE C 163 -16.787-9.983 -41. 390 1. 00 26. 00 C
ATOM 4272 CB ILE C 163 -17.167 -8.511 -41. 140 1. 00 23. 13 CATOM 4272 CB ILE C 163 -17.167 -8.511 -41. 140 1. 00 23. 13 C
ATOM 4273 CG2 ILE C 163 -15.965 -7.745 -40. 612 1. 00 24.45 CATOM 4273 CG2 ILE C 163 -15.965 -7.745 -40. 612 1. 00 24.45 C
ATOM 4274 CG1 ILE C 163 - 17.676 -7.878 -42. 432 1. 00 24.83 CATOM 4274 CG1 ILE C 163-17.676 -7.878 -42. 432 1. 00 24.83 C
ATOM 4275 CD1 ILE C 163 -18.207 -6.455 -42. 253 1. 00 26.88 CATOM 4275 CD1 ILE C 163 -18.207 -6.455 -42. 253 1.00 26.88 C
ATOM 4276 C ILE C 163 -16.212 -10.554 - 40. 105 1. ,00 25.45 CATOM 4276 C ILE C 163 -16.212 -10.554-40. 105 1., 00 25.45 C
ATOM 4277 0 ILE C 163 - 16.953 -10.844 -39. 175 1. 00 24.87 0ATOM 4277 0 ILE C 163-16.953 -10.844 -39. 175 1. 00 24.87 0
ATOM 4278 N LYS C 164 -14.892 -10.710 -40. 068 1. ,00 24. 55 NATOM 4278 N LYS C 164 -14.892 -10.710 -40. 068 1., 00 24. 55 N
ATOM 4279 CA LYS C 164 -14.178 -11.138 - 38. 869 1, ,00 24. 33 CATOM 4279 CA LYS C 164 -14.178 -11.138-38. 869 1,, 00 24. 33 C
ATOM 4280 CB LYS C 164 -13.650 -12.568 -39. 043 1. ,00 22. 91 CATOM 4280 CB LYS C 164 -13.650 -12.568 -39. 043 1., 00 22. 91 C
ATOM 4281 CG LYS C 164 一 14.709 - 13.557 - 39. 517 1. .00 25. 26 CATOM 4281 CG LYS C 164 I 14.709-13.557-39. 517 1. .00 25. 26 C
ATOM 4282 CD LYS C 164 -14.180 - 14.988 -39.611 1. .00 26. 10 CATOM 4282 CD LYS C 164 -14.180-14.988 -39.611 1. .00 26. 10 C
ATOM 4283 CE LYS C 164 -15.319 -15.974 -39. 887 1. .00 26. 00 CATOM 4283 CE LYS C 164 -15.319 -15.974 -39. 887 1. .00 26. 00 C
ATOM 4284 NZ LYS C 164 -15.151 -17.256 -39. 118 1. .00 28. 53 NATOM 4284 NZ LYS C 164 -15.151 -17.256 -39. 118 1. .00 28. 53 N
ATOM 4285 C LYS C 164 -13.010 -10.187 - 38. 629 1. .00 23. 28 CATOM 4285 C LYS C 164 -13.010 -10.187-38. 629 1. .00 23. 28 C
ATOM 4286 0 LYS C 164 -12.434 - 9.648 -39. 571 1, .00 22. 37 0ATOM 4286 0 LYS C 164 -12.434-9.648 -39. 571 1, .00 22. 37 0
ATOM 4287 N VAL c 165 -12.670 -9.985 -37. 363 1, .00 23. 08 NATOM 4287 N VAL c 165 -12.670 -9.985 -37. 363 1, .00 23. 08 N
ATOM 4288 CA VAL c 165 -11.592 -9.087 -36. 985 1, .00 23. 71 CATOM 4288 CA VAL c 165 -11.592 -9.087 -36.985 1, .00 23. 71 C
ATOM 4289 CB VAL c 165 - 12.109 -8.010 -36. 012 1, .00 23. 60 CATOM 4289 CB VAL c 165-12.109 -8.010 -36. 012 1, .00 23. 60 C
ATOM 4290 CG1 VAL c 165 -10.981 - 7.064 -35. 626 1 .00 19. 98 CATOM 4290 CG1 VAL c 165 -10.981-7.064 -35. 626 1 .00 19. 98 C
ATOM 4291 CG2 VAし c 165 -13.266 -7.256 -36. 648 1 .00 20. 12 CATOM 4291 CG2 VA c 165 -13.266 -7.256 -36.648 1 .00 20. 12 C
ATOM 4292 C VAL c 165 - 10.483 -9.886 -36. 297 1 .00 25. 41 CATOM 4292 C VAL c 165-10.483 -9.886 -36.297 1 .00 25. 41 C
ATOM 4293 0 VAL c 165 -10.757 -10.681 - 35. 401 1 • 00 26. ,70 0ATOM 4293 0 VAL c 165 -10.757 -10.681-35. 401 1 • 00 26., 70 0
ATOM 4294 N LEU c 166 - 9.237 -9.690 - 36. 717 1 .00 24. 51 NATOM 4294 N LEU c 166-9.237 -9.690-36. 717 1 .00 24. 51 N
ATOM 4295 CA LEU c 166 -8.124一 10.348 —36. ,039 1 .00 23, ,45 C ATOM 4296 CB LEU C 166 -7.263 - 11.132 -37.027 1.00 20.78 CATOM 4295 CA LEU c 166 -8.124 1 10.348 —36., 039 1 .00 23,, 45 C ATOM 4296 CB LEU C 166 -7.263-11.132 -37.027 1.00 20.78 C
ATOM 4297 ce LEU C 166 - 7. 997 -11. 877 -38. 137 1. 00 23.39 CATOM 4297 ce LEU C 166-7. 997 -11. 877 -38. 137 1. 00 23.39 C
ATOM 4298 CD1 LEU C 166 - 7. 005 -12.643 -39. 009 1. 00 24.68 CATOM 4298 CD1 LEU C 166-7. 005 -12.643 -39. 009 1.00 24.68 C
ATOM 4299 CD2 LEU C 166 -8.997 -12.811 -37. 530 1. 00 24.95 CATOM 4299 CD2 LEU C 166 -8.997 -12.811 -37. 530 1.00 24.95 C
ATOM 4300 C LEU G 166 - 7.261 - 9.305 -35. 345 1. 00 21. 92 CATOM 4300 C LEU G 166-7.261-9.305 -35. 345 1. 00 21. 92 C
ATOM 4301 0 LEU C 166 -6.766 -8.378 -35. 982 1. 00 20.46 0ATOM 4301 0 LEU C 166 -6.766 -8.378 -35. 982 1. 00 20.46 0
ATOM 4302 N VAL C 167 -7. 081 -9.456一 34.038 1. 00 20.38 NATOM 4302 N VAL C 167 -7. 081 -9.456 1 34.038 1. 00 20.38 N
ATOM 4303 CA VAL C 167 - 6.207 -8.556 -33. 318 1. 00 20.91 CATOM 4303 CA VAL C 167-6.207 -8.556 -33. 318 1. 00 20.91 C
ATOM 4304 CB VAL C 167 - 7. 034 -7.558 -32. 494 1. 00 21. 15 CATOM 4304 CB VAL C 167-7. 034 -7.558 -32. 494 1. 00 21. 15 C
ATOM 4305 C61 VAL C 167 - 8.187 -7. 030 -33. 354 1. 00 19.32 CATOM 4305 C61 VAL C 167-8.187 -7. 030 -33. 354 1. 00 19.32 C
ATOM 4306 CG2 VAL C 167 -7. 554 -8.209 - 31. 237 1. 00 19.82 CATOM 4306 CG2 VAL C 167 -7. 554 -8.209-31. 237 1. 00 19.82 C
ATOM 4307 C VAL C 167 - 5. 244 -9.318 -32. 419 1. 00 22.21 CATOM 4307 C VAL C 167-5. 244 -9.318 -32. 419 1. 00 22.21 C
ATOM 4308 0 VAL C 167 - 5. 529 - 10. 437 -32. 006 1. 00 23. 10 0ATOM 4308 0 VAL C 167-5. 529-10. 437 -32. 006 1. 00 23. 10 0
ATOM 4309 N LEU C 168 -4. 096 -8. 712 -32. 130 1. 00 22. 76 NATOM 4309 N LEU C 168 -4. 096 -8. 712 -32. 130 1. 00 22. 76 N
ATOM 4310 CA LEU C 168 -3. 090 -9. 325 -31. 268 1. 00 21. 51 CATOM 4310 CA LEU C 168 -3. 090 -9. 325 -31. 268 1. 00 21. 51 C
ATOM 4311 CB LEU C 168 - 1. 732 -8. 649 -31. 497 1. 00 20. 44 CATOM 4311 CB LEU C 168-1. 732 -8. 649 -31. 497 1. 00 20. 44 C
ATOM 4312 CG LEU C 168 - 0. 794 - 9. 324 -32. 512 1. 00 21. 50 CATOM 4312 CG LEU C 168-0. 794-9. 324 -32. 512 1. 00 21. 50 C
ATOM 4313 CD1 LEU C 168 - 1. 584 - 9. 905 - 33. 649 1. 00 20. 81 CATOM 4313 CD1 LEU C 168-1. 584-9. 905-33. 649 1. 00 20. 81 C
ATOM 4314 CD2 LEU C 168 0. 225 -8. 328 -33. 028 1. .00 19. 04 CATOM 4314 CD2 LEU C 168 0. 225 -8. 328 -33. 028 1. .00 19. 04 C
ATOM 4315 C LEU C 168 -3. 501 -9. 206 -29. 802 1. 00 23. 01 CATOM 4315 C LEU C 168 -3. 501 -9. 206 -29. 802 1.00 23. 01 C
ATOM 4316 0 LEU C 168 -3. 330 - 10. 137 - 29. 010 1. 00 20. 94 0ATOM 4316 0 LEU C 168 -3. 330-10. 137-29. 010 1. 00 20. 94 0
ATOM 4317 N VAL C 169 4. 065 - 8. 054 -29. 450 1. ,00 24. 45 NATOM 4317 N VAL C 169 4. 065-8. 054 -29. 450 1., 00 24. 45 N
ATOM 4318 CA VAL C 169 - 4. 472 -7. 786 -28.078 1. ,00 24. 65 CATOM 4318 CA VAL C 169-4. 472 -7. 786 -28.078 1., 00 24. 65 C
ATOM 4319 CB VAL C 169 -3. 326 -7. 112 -27. 299 1. .00 28. 57 CATOM 4319 CB VAL C 169 -3. 326 -7. 112 -27. 299 1. .00 28. 57 C
ATOM 4320 CG1 VAL C 169 -2. 965 -5. 771 - 27. 943 1. ,00 27. 39 CATOM 4320 CG1 VAL C 169 -2. 965 -5. 771-27. 943 1., 00 27. 39 C
ATOM 4321 CG2 VAL C 169 - 3. 735 -6. 920 -25. 860 1. ,00 32. 76 CATOM 4321 CG2 VAL C 169-3. 735 -6. 920 -25. 860 1., 00 32. 76 C
ATOM 4322 C VAL C 169 -5. 726 - 6. 904 -28. 002 1. ,00 24. 21 CATOM 4322 C VAL C 169 -5. 726-6. 904 -28. 002 1., 00 24. 21 C
ATOM 4323 0 VAL C 169 -5. 935 -6. 029 -28. 840 1. .00 24. 66 0ATOM 4323 0 VAL C 169 -5. 935 -6. 029 -28. 840 1. .00 24. 66 0
ATOM 4324 N ALA C 170 -6. 557 -7. 148 -26. 993 1. .00 22. 80 NATOM 4324 N ALA C 170 -6. 557 -7. 148 -26. 993 1. .00 22. 80 N
ATO 4325 CA ALA c 170 -7. 847 -6. 486 - 26. 883 1. .00 22. 45 CATO 4325 CA ALA c 170 -7. 847 -6. 486-26. 883 1. .00 22. 45 C
ATOM 4326 CB ALA c 170 -8. 907 -7. 319 -27. 565 1, .00 21. 01 CATOM 4326 CB ALA c 170 -8. 907 -7. 319 -27. 565 1, .00 21. 01 C
ATOM 4327 C ALA c 170 -8. 221 - 6. 248 -25. 422 1. .00 24. 63 CATOM 4327 C ALA c 170 -8. 221-6. 248 -25. 422 1. .00 24. 63 C
ATOM 4328 0 ALA c 170 -8. 076 -7. 132 -24. 580 1. .00 25. 77 0ATOM 4328 0 ALA c 170 -8. 076 -7. 132 -24. 580 1. .00 25. 77 0
ATOM 4329 N ALA c 171 - 8. 690 -5. 043 -25. 120 1, .00 26. 75 NATOM 4329 N ALA c 171-8. 690 -5. 043 -25. 120 1, .00 26. 75 N
ATOM 4330 CA ALA c 171 -9. 179 -4. 733 -23. 779 1, .00 28. 35 CATOM 4330 CA ALA c 171 -9. 179 -4. 733 -23. 779 1, .00 28. 35 C
ATOM 4331 CB ALA c 171 -8. 947 —3. 264 -23. 456 1. .00 27. 33 C ATOM 4332 C ALA C 171 - 10.665 -5.049 -23.735 1.00 29.55 CATOM 4331 CB ALA c 171 -8. 947 —3. 264 -23. 456 1. .00 27. 33 C ATOM 4332 C ALA C 171-10.665 -5.049 -23.735 1.00 29.55 C
ATOM 4333 0 ALA C 171 -11.354 -4.967 -24.757 1. 00 29.58 0ATOM 4333 0 ALA C 171 -11.354 -4.967 -24.757 1. 00 29.58 0
ATOM 4334 N PRO C 172 -11.178 -5.417 -22.551 1. 00 29.31 NATOM 4334 N PRO C 172 -11.178 -5.417 -22.551 1. 00 29.31 N
ATOM 4335 CD PRO C 172 - 10.431 - 5.569 -21. 291 1. 00 30.00 CATOM 4335 CD PRO C 172-10.431-5.569 -21. 291 1.00 30.00 C
ATOM 4336 CA PRO C 172 -12.590 -5.797 -22.400 1. 00 30.19 CATOM 4336 CA PRO C 172 -12.590 -5.797 -22.400 1. 00 30.19 C
ATOM 4337 CB PRO C 172 - 12.749 -6.002 -20. 888 1. 00 28.34 CATOM 4337 CB PRO C 172-12.749 -6.002 -20. 888 1. 00 28.34 C
ATOM 4338 C6 PRO C 172 -11.372 -6.394 - 20. 434 1. 00 28.54 CATOM 4338 C6 PRO C 172 -11.372 -6.394-20. 434 1. 00 28.54 C
ATOM 4339 C PRO C 172 -13.573 -4.765 -22. 956 1. 00 30.09 CATOM 4339 C PRO C 172 -13.573 -4.765 -22. 956 1. 00 30.09 C
ATOM 4340 0 PRO C 172 -14.502 -5.119 -23. 684 1. 00 31.36 0ATOM 4340 0 PRO C 172 -14.502 -5.119 -23. 684 1. 00 31.36 0
ATOM 4341 N 6LU C 173 -13.352 -3.493 -22. 632 1. 00 29.16 NATOM 4341 N 6LU C 173 -13.352 -3.493 -22. 632 1. 00 29.16 N
ATOM 4342 CA 6LU C 173 -14.272 -2.439 -23. 037 1. 00 30.84 CATOM 4342 CA 6LU C 173 -14.272 -2.439 -23. 037 1. 00 30.84 C
ATOM 4343 CB GLU C 173 -13.919 -1.136 - 22, 328 1. 00 35.33 CATOM 4343 CB GLU C 173 -13.919 -1.136-22, 328 1. 00 35.33 C
ATOM 4344 CG GLU C 173 - 12.617 -0.515 -22. 770 1. 00 38.29 . CATOM 4344 CG GLU C 173-12.617 -0.515 -22. 770 1. 00 38.29. C
ATOM 4345 CD GLU C 173 - 12.199 0.616 -21. 857 1. 00 43.11 CATOM 4345 CD GLU C 173-12.199 0.616 -21.857 1.00 43.11 C
ATOM 4346 0E1 GLU C 173 -12.457 1.791 - 22. 202 1. 00 45.63 0ATOM 4346 0E1 GLU C 173 -12.457 1.791-22. 202 1.00 45.63 0
ATOM 4347 0E2 GLU C 173 -11.620 0.329 -20. 787 1. 00 45.48 0ATOM 4347 0E2 GLU C 173 -11.620 0.329 -20. 787 1. 00 45.48 0
ATOM 4348 C GLU C 173 -14.290 -2.206 -24. 543 1. ,00 29.65 CATOM 4348 C GLU C 173 -14.290 -2.206 -24. 543 1., 00 29.65 C
ATOM 4349 0 GLU C 173 -15.324 -1.858 - 25. 110 1. ,00 29.19 0ATOM 4349 0 GLU C 173 -15.324 -1.858-25. 110 1., 00 29.19 0
ATOM 4350 N GLY C 174 -13.141 - 2.390 -25. 187 1. ,00 29.16 NATOM 4350 N GLY C 174 -13.141-2.390 -25. 187 1., 00 29.16 N
ATOM 4351 CA GLY C 174 - 13.103 -2.393 -26. 636 1. .00 25.16 CATOM 4351 CA GLY C 174-13.103 -2.393 -26. 636 1. .00 25.16 C
ATOM 4352 C GLY C 174 -13.955 -3.516 -27. 189 1. .00 24.48 CATOM 4352 C GLY C 174 -13.955 -3.516 -27. 189 1. .00 24.48 C
ATOM 4353 0 GLY C 174 -14.733 -3.316 -28. 121 1. .00 25.26 0ATOM 4353 0 GLY C 174 -14.733 -3.316 -28. 121 1. .00 25.26 0
ATOM 4354 N ILE C 175 -13.823 - 4.703 -26.608 1, .00 23.67 NATOM 4354 N ILE C 175 -13.823-4.703 -26.608 1, .00 23.67 N
ATOM 4355 CA ILE C 175 - 14.622 -5.839 - 27. 043 1, .00 23.88 CATOM 4355 CA ILE C 175-14.622 -5.839-27. 043 1, .00 23.88 C
ATOM 4356 CB ILE C 175 - 14.196 - 7.143 -26. 329 1. .00 25.49 CATOM 4356 CB ILE C 175-14.196-7.143 -26. 329 1. .00 25.49 C
ATOM 4357 CG2 ILE C 175 -15.046 -8.298 -26. 804 1, ■ 00 25.68 CATOM 4357 CG2 ILE C 175 -15.046 -8.298 -26. 804 1, ∎ 00 25.68 C
ATOM 4358 C61 ILE C 175 -12.733 - 7.464 -26. 641 1, .00 25.82 CATOM 4358 C61 ILE C 175 -12.733-7.464 -26. 641 1, .00 25.82 C
ATOM 4359 CD1 ILE c 175 -12.130 -8.495 -25. 706 1, .00 28.17 CATOM 4359 CD1 ILE c 175 -12.130 -8.495 -25. 706 1, .00 28.17 C
ATOM 4360 C ILE c 175 -16.097 - 5.582 -26. 767 1 .00 24.80 CATOM 4360 C ILE c 175 -16.097-5.582 -26.767 1 .00 24.80 C
ATOM 4361 0 ILE c 175 -16.950 -5.915 -27. 585 1 • 00 24.94 0ATOM 4361 0 ILE c 175 -16.950 -5.915 -27. 585 1 • 00 24.94 0
ATOM 4362 N ALA G 176 -16.402 - 4.975 -25. 623 1 ■ 00. 25.10 NATOM 4362 N ALA G 176 -16.402-4.975 -25. 623 1 ∎ 00. 25.10 N
ATOM 4363 CA ALA C 176 -17.790 -4.679 -25. 292 1 .00 26.65 CATOM 4363 CA ALA C 176 -17.790 -4.679 -25. 292 1 .00 26.65 C
ATOM 4364 CB ALA C 176 -17.887 - 4.100 - 23. ,881 1 .00 27.04 CATOM 4364 CB ALA C 176 -17.887-4.100-23., 881 1 .00 27.04 C
ATOM 4365 C ALA C 176 -18.414 -3.718 -26. ,304 1 .00 27.46 CATOM 4365 C ALA C 176 -18.414 -3.718 -26., 304 1 .00 27.46 C
ATOM 4366 0 ALA C 176 -19.533 -3.938 -26. .769 1 .00 28.96 0ATOM 4366 0 ALA C 176 -19.533 -3.938 -26..769 1 .00 28.96 0
ATOM 4367 N ALA c 177 -17.687 -2.661 -26. .653 1 .00 27.15 N ATOM 4368 CA ALA C 177 -18.151 -27.674 1.00 28.24 CATOM 4367 N ALA c 177 -17.687 -2.661 -26..653 1 .00 27.15 N ATOM 4368 CA ALA C 177 -18.151 -27.674 1.00 28.24 C
ATOM 4369 CB ALA C 177 -17.195 - 0.536 -27.767 1. 00 26.20 CATOM 4369 CB ALA C 177 -17.195-0.536 -27.767 1. 00 26.20 C
ATOM 4370 C ALA C 177 -18.288 -2.391 -29.044 1. 00 30.20 CATOM 4370 C ALA C 177 -18.288 -2.391 -29.044 1. 00 30.20 C
ATOM 4371 0 ALA C 177 -19.115 -1.986 -29. 858 1. 00 30.77 0ATOM 4371 0 ALA C 177 -19.115 -1.986 -29. 858 1. 00 30.77 0
ATOM 4372 N LEU C 178 -17.472 -3.412 -29. 299 1. 00 32.16 NATOM 4372 N LEU C 178 -17.472 -3.412 -29. 299 1. 00 32.16 N
ATOM 4373 CA LEU C 178 -17.520 -4.125 -30. 573 1. 00 32.66 CATOM 4373 CA LEU C 178 -17.520 -4.125 -30. 573 1. 00 32.66 C
ATOM 4374 CB LEU C 178 -16.311 -5.053 -30. 712 1. 00 32.62 CATOM 4374 CB LEU C 178 -16.311 -5.053 -30. 712 1. 00 32.62 C
ATOM 4375 CG LEU C 178 -15.818 -5.395 -32. 121 1. 00 33.36 CATOM 4375 CG LEU C 178 -15.818 -5.395 -32. 121 1. 00 33.36 C
ATOM 4376 CD1 LEU C 178 -15.250 - 6.802 - 32. 106 1. 00 30.90 CATOM 4376 CD1 LEU C 178 -15.250-6.802-32. 106 1. 00 30.90 C
ATOM 4377 CD2 LEU C 178 -16.942 -5.282 -33. 142 1. 00 32.62 CATOM 4377 CD2 LEU C 178 -16.942 -5.282 -33. 142 1. 00 32.62 C
ATOM 4378 C LEU C 178 - 18.795 - 4.955 -30. 644 1. 00 33.51 CATOM 4378 C LEU C 178-18.795-4.955 -30. 644 1. 00 33.51 C
ATOM 4379 .0 LEU C 178 -19.519 -4.911 -31. 636 1. 00 33.84 0ATOM 4379 .0 LEU C 178 -19.519 -4.911 -31. 636 1. 00 33.84 0
ATOM 4380 N 6LU C 179 - 19. 063 -5.717 -29. 590 1. 00 34.21 .ATOM 4380 N 6LU C 179-19. 063 -5.717 -29. 590 1. 00 34.21.
ATOM 4381 CA GLU G 179 -20. 252 - 6.551 - 29. 557 1. 00 36.90 CATOM 4381 CA GLU G 179 -20. 252-6.551-29. 557 1. 00 36.90 C
ATOM 4382 CB GLU C 179 -20. 293 -7.362 -28. 258 1. 00 38.81 CATOM 4382 CB GLU C 179 -20. 293 -7.362 -28. 258 1. 00 38.81 C
ATOM 4383 CG GLU C 179 -19. 081 - 8.260 -28. 043 1. 00 42.09 cATOM 4383 CG GLU C 179 -19. 081-8.260 -28. 043 1. 00 42.09 c
ATOM 4384 CD GLU C 179 —19. 230 -9.167 - 26. 827 1. 00 43.95 cATOM 4384 CD GLU C 179 —19. 230 -9.167-26. 827 1. 00 43.95 c
ATOM 4385 0E1 GLU C 179 -18. 989 -8.689 -25. 695 1. 00 44.27 0ATOM 4385 0E1 GLU C 179 -18. 989 -8.689 -25. 695 1. 00 44.27 0
ATOM 4386 0E2 GLU C 179 -19. 587 -10.355 - 27. 008 1. .00 42.30 0ATOM 4386 0E2 GLU C 179 -19. 587 -10.355-27. 008 1. .00 42.30 0
ATOM 4387 C GLU C 179 - 21. 501 -5.680 -29. 664 1. ,00 37.56 GATOM 4387 C GLU C 179-21. 501 -5.680 -29. 664 1., 00 37.56 G
ATOM 4388 0 GLU C 179 -22. 430 -5.985 -30. 417 1. ,00 38.29 0ATOM 4388 0 GLU C 179 -22. 430 -5.985 -30. 417 1., 00 38.29 0
ATOM 4389 N LYS C 180 -21. 513 -4.585 - 28. 918 1. .00 37.21 NATOM 4389 N LYS C 180 -21. 513 -4.585-28. 918 1. .00 37.21 N
ATOM 4390 CA LYS C 180 -22. 674 -3.709 1. .00 37.87 CATOM 4390 CA LYS C 180 -22. 674 -3.709 1. .00 37.87 C
ATOM 4391 CB LYS C 180 - 22. 413 - 2.558 -27. 904 1. .00 39.34 CATOM 4391 CB LYS C 180-22. 413-2.558 -27. 904 1. .00 39.34 C
ATOM 4392 CG LYS C 180 -23. 636 -1.741 -27. 532 1. .00 43.66 CATOM 4392 CG LYS C 180 -23. 636 -1.741 -27. 532 1. .00 43.66 C
ATOM 4393 CD LYS C 180 -23. 288 -0.724 - 26. 449 1, .00 46.80 CATOM 4393 CD LYS C 180 -23. 288 -0.724-26. 449 1, .00 46.80 C
ATOM 4394 CE LYS C 180 - 24. 375 0.328 - 26. 300 1, .00 49.82 GATOM 4394 CE LYS C 180-24. 375 0.328-26. 300 1, .00 49.82 G
ATOM 4395 NZ LYS C 180 -23. 807 1.676 -25. 989 1. .00 51.50 NATOM 4395 NZ LYS C 180 -23. 807 1.676 -25. 989 1. .00 51.50 N
ATOM 4396 C LYS c 180 - 23. 004 - 3.162 -30. 275 1, .00 35.51 CATOM 4396 C LYS c 180-23. 004-3.162 -30. 275 1, .00 35.51 C
ATOM 4397 0 LYS c 180 - 24. 144 -3.246 - 30. 726 1, .00 35.69 0ATOM 4397 0 LYS c 180-24. 144 -3.246-30. 726 1, .00 35.69 0
ATOM 4398 N ALA c 181 -22. 005 -2.616 -30. 960 1, .00 33.73 NATOM 4398 N ALA c 181 -22. 005 -2.616 -30. 960 1, .00 33.73 N
ATOM 4399 CA ALA c 181 -22. 237 - 1.963 -32. 247 1 .00 32.58 CATOM 4399 CA ALA c 181 -22. 237-1.963 -32. 247 1 .00 32.58 C
ATOM 4400 CB ALA c 181 - 21. 074 -1.044 -32. 585 t .00 30.33 CATOM 4400 CB ALA c 181-21. 074 -1.044 -32. 585 t .00 30.33 C
ATOM 4401 C ALA c 181 -22. 447 -2.958 -33. 376 1, .00 31.38 CATOM 4401 C ALA c 181 -22. 447 -2.958 -33. 376 1, .00 31.38 C
ATOM 4402 0 ALA c 181 - 23. 220 -2.708 -34. 303 1 ■ 00 32.05 0ATOM 4402 0 ALA c 181-23. 220 -2.708 -34. 303 1 ∎ 00 32.05 0
ATOM 4403 N HIS c 182 一 21. 747 —4.083一 33. 302 1 • 00 N JP2007/071755 ATOM 4403 N HIS c 182 1 21. 747 —4.083 1 33. 302 1 • 00 N JP2007 / 071755
ATOM 4404 CA HIS C 182 -21. 795 -5.077 -34.363 1. 0033.01 CATOM 4404 CA HIS C 182 -21. 795 -5.077 -34.363 1. 0033.01 C
ATOM 4405 CB HIS C 182 - 20. 617 -4.873 -35.310 1. 00 32.12 CATOM 4405 CB HIS C 182-20. 617 -4.873 -35.310 1. 00 32.12 C
ATOM 4406 GG HIS C 182 -20. 622 - 3.549 -36.005 1. 00 30.23 CATOM 4406 GG HIS C 182 -20. 622-3.549 -36.005 1. 00 30.23 C
ATOM 4407 CD2 HIS C 182 -19. 889 -2.430一 35.797 1. 00 31.52 CATOM 4407 CD2 HIS C 182 -19. 889 -2.430 1 35.797 1. 00 31.52 C
ATOM 4408 ND1 HIS C 182 -21. 446 -3.276 -37.075 1. 00 29.55 NATOM 4408 ND1 HIS C 182 -21. 446 -3.276 -37.075 1. 00 29.55 N
ATOM 4409 CE1 HIS C 182 -21. 219 -2.046 -37.499 1. 0030.92 CATOM 4409 CE1 HIS C 182 -21. 219 -2.046 -37.499 1. 0030.92 C
ATOM 4410 NE2 HIS C 182 -20. 278 - 1.510 - 36.741 1. 00 33.12 NATOM 4410 NE2 HIS C 182 -20. 278-1.510-36.741 1. 00 33.12 N
ATOM 4411 C HIS C 182 -21. 771 -6.497 -33.798 1. 00 34.25 CATOM 4411 C HIS C 182 -21. 771 -6.497 -33.798 1. 00 34.25 C
ATOM 4412 0 HIS C 182 -20. 734 -7.162 -33.785 1. 0036.52 0ATOM 4412 0 HIS C 182 -20. 734 -7.162 -33.785 1. 0036.52 0
ATOM 4413 N PRO C 183 -22. 926 -6.979 - 33.321 1. 00 33.70 NATOM 4413 N PRO C 183 -22. 926 -6.979-33.321 1. 00 33.70 N
ATOM 4414 CD PRO C 183 -24. 218 -6.269 -33.331 1. 00 32.35 CATOM 4414 CD PRO C 183 -24. 218 -6.269 -33.331 1. 00 32.35 C
ATOM 4415 ,CA PRO C 183 -23. 020 -8.286 -32.668 1. 0032.09 CATOM 4415, CA PRO C 183 -23. 020 -8.286 -32.668 1. 0032.09 C
ATOM 4416 CB PRO C 183 -24. 406 -8.267 -32.031 1. 00 31.83 CATOM 4416 CB PRO C 183 -24. 406 -8.267 -32.031 1. 00 31.83 C
ATOM 4417 CG PRO C 183 -25. 192 - 7.325 - 32.886 1. 00 32.82 CATOM 4417 CG PRO C 183 -25. 192-7.325-32.886 1. 00 32.82 C
ATOM 4418 C PRO C 183 -22. 849 -9.448 - 33.638 1. 00 31.60 CATOM 4418 C PRO C 183 -22. 849 -9.448-33.638 1. 00 31.60 C
ATOM 4419 0 PRO C 183 -22. 709 -10.598 -33.225 1. 00 31.71 0ATOM 4419 0 PRO C 183 -22. 709 -10.598 -33.225 1. 00 31.71 0
ATOM 4420 N ASP C 184 -22. 863 -9.146 -34.929 1. 0031.80 NATOM 4420 N ASP C 184 -22. 863 -9.146 -34.929 1. 0031.80 N
ATOM 4421 CA ASP C 184 -22. 793 -10.186 -35.948 1. 00 31.79 CATOM 4421 CA ASP C 184 -22. 793 -10.186 -35.948 1. 00 31.79 C
ATOM 4422 CB ASP C 184 -23. 660 -9.798 -37.146 1. 00 34.14 CATOM 4422 CB ASP C 184 -23. 660 -9.798 -37.146 1. 00 34.14 C
ATOM 4423 CG ASP C 184 -23. 265 -8.460 -37.735 1. .00 39.25 CATOM 4423 CG ASP C 184 -23. 265 -8.460 -37.735 1. .00 39.25 C
ATOM 4424 0D1 ASP C 184 -23. 439 -8.272 - 38.958 1. , 00 40.93 0ATOM 4424 0D1 ASP C 184 -23. 439 -8.272-38.958 1., 00 40.93 0
ATOM 4425 0D2 ASP C 184 -22. 773 - 7.596 -36.973 1. , 0041.24 0ATOM 4425 0D2 ASP C 184 -22. 773-7.596 -36.973 1., 0041.24 0
ATOM 4426 C ASP C 184 -21. 363 - 10.441 -36.415 1. ,00 31.86 CATOM 4426 C ASP C 184 -21.363-10.441 -36.415 1., 00 31.86 C
ATOM 4427 0 ASP c 184 -21. 132 -11.278 -37.288 1. ,00 31.02 0ATOM 4427 0 ASP c 184 -21. 132 -11.278 -37.288 1., 00 31.02 0
ATOM 4428 N VAL c 185 -20. 403 - 9.719 - 35.840 1. ,0031.60 NATOM 4428 N VAL c 185 -20. 403-9.719-35.840 1., 0031.60 N
ATOM 4429 CA VAし c 185 -19. 012 -9.838 -36.276 1. .00 29.49 CATOM 4429 CA VA c 185 -19. 012 -9.838 -36.276 1. .00 29.49 C
ATOM 4430 CB VAL c 185 -18. 372 -8.452 -36.494 1, .00 31.27 CATOM 4430 CB VAL c 185 -18. 372 -8.452 -36.494 1, .00 31.27 C
ATOM 4431 CG1 VAL c 185 -16. 906 -8.617 -36.912 1. .00 30.57 CATOM 4431 CG1 VAL c 185 -16. 906 -8.617 -36.912 1..00 30.57 C
ATOM 4432 CG2 VAL c 185 -19. 159 -7.673 -37.553 1, .00 27.52 CATOM 4432 CG2 VAL c 185 -19. 159 -7.673 -37.553 1, .00 27.52 C
ATO 4433 C VAL c 185 -18. 160 -10.605 -35.283 1, .00 28.61 CATO 4433 C VAL c 185 -18. 160 -10.605 -35.283 1, .00 28.61 C
ATOM 4434 0 VAL c 185 - 18. 114 -10.263 -34.104 1, .00.28.40 0ATOM 4434 0 VAL c 185-18. 114 -10.263 -34.104 1, .00.28.40 0
ATOM 4435 N GLU c 186 一 17. 478 -11.641 -35.770 1 .00 29.34 NATOM 4435 N GLU c 186 1 17. 478 -11.641 -35.770 1 .00 29.34 N
ATOM 4436 CA GLU c 186 -16. 590 -12.450 -34.935 1 ■ 00 27.81 CATOM 4436 CA GLU c 186 -16. 590 -12.450 -34.935 1 ■ 00 27.81 C
ATOM 4437 CB GLU c 186 -16. 242 -13.759 -35.642 1 • 00 29.85 CATOM 4437 CB GLU c 186 -16. 242 -13.759 -35.642 1 • 00 29.85 C
ATOM 4438 C6 GLU c 186 -17. 430 - 14.593 -36.057 1 • 00 33.25 CATOM 4438 C6 GLU c 186 -17. 430-14.593 -36.057 1 • 00 33.25 C
ATOM 4439 CD GLU c 186 一 17. 047 -16.027 -36.322 1 .00 35.24 C ATOM 4440 0E1 GLU C 186 -17.933 -16.818 -36.688 1.00 36.53 0ATOM 4439 CD GLU c 186 1 17. 047 -16.027 -36.322 1 .00 35.24 C ATOM 4440 0E1 GLU C 186 -17.933 -16.818 -36.688 1.00 36.53 0
ATOM 4441 0E2 GLU C 186 -15.854 -16.364 -36.162 1. 00 39.53 0ATOM 4441 0E2 GLU C 186 -15.854 -16.364 -36.162 1.00 39.53 0
ATOM 4442 C GLU C 186 一 15.287 -11.725 —34.592 1. 00 26.64 CATOM 4442 C GLU C 186 1 15.287 -11.725 —34.592 1. 00 26.64 C
ATOM 4443 0 GLU C 186 -14.717 -11.017 -35.420 1. 00 25.82 0ATOM 4443 0 GLU C 186 -14.717 -11.017 -35.420 1.00 25.82 0
ATOM 4444 N LEU C 187 -14.820 -11.915 -33.366 1. 00 25.86 NATOM 4444 N LEU C 187 -14.820 -11.915 -33.366 1. 00 25.86 N
ATOM 4445 CA LEU C 187 - 13.491 -11.465 -32.979 1. 00 27.20 CATOM 4445 CA LEU C 187-13.491 -11.465 -32.979 1. 00 27.20 C
ATOM 4446 CB LEU C 187 -13.582 -10.537 1. 00 25.30 CATOM 4446 CB LEU C 187 -13.582 -10.537 1. 00 25.30 C
ATOM 4447 CG LEU C 187 -12.263 -9.941 -31.254 1. 00 26.29 CATOM 4447 CG LEU C 187 -12.263 -9.941 -31.254 1. 00 26.29 C
ATOM 4448 CD1 LEU C 187 -11.758 - 8.932 -32.266 1. 00 23.47 CATOM 4448 CD1 LEU C 187 -11.758-8.932 -32.266 1. 00 23.47 C
ATOM 4449 CD2 LEU C 187 -12.459 -9.285 -29.895 1. 00 24.91 CATOM 4449 CD2 LEU C 187 -12.459 -9.285 -29.895 1.00 24.91 C
ATOM 4450 C LEU C 187 -12.567 -12.656 -32.663 1. 00 27.89 CATOM 4450 C LEU C 187 -12.567 -12.656 -32.663 1. 00 27.89 C
ATOM 4451 ,0 LEU C 187 -12.929 -13.563 -31.902 1. 00 25.43 0ATOM 4451, 0 LEU C 187 -12.929 -13.563 -31.902 1.00 25.43 0
ATOM 4452 N TYR C 188 -11.378 -12.642 -33.257 1. 00 27.15 -ATOM 4452 N TYR C 188 -11.378 -12.642 -33.257 1. 00 27.15-
ATOM 4453 CA TYR C 188 -10.298 -13.535 - 32.855 1. 00 27.85 CATOM 4453 CA TYR C 188 -10.298 -13.535-32.855 1. 00 27.85 C
ATOM 4454 CB TYR C 188 - 9.876 -14.432 -34.02 003 1. 00 27.89 CATOM 4454 CB TYR C 188-9.876 -14.432 -34.02 003 1. 00 27.89 C
ATOM 4455 CG TYR C 188 - 10.954 -15.389 - 34.461 1. 00 28.39 CATOM 4455 CG TYR C 188-10.954 -15.389-34.461 1.00 28.39 C
ATOM 4456 CD1 TYR C 188 -11.972 - 14.972 -35.305 1. 00 28.19 CATOM 4456 CD1 TYR C 188 -11.972-14.972 -35.305 1. 00 28.19 C
ATOM 4457 CE1 TYR C 188 - 12.970 -15.833 -35.697 1. 00 28.25 CATOM 4457 CE1 TYR C 188-12.970 -15.833 -35.697 1.00 28.25 C
ATOM 4458 CD2 TYR C 188 -10.964 ，16.707 -34.021 1. 00 27.65 CATOM 4458 CD2 TYR C 188 -10.964, 16.707 -34.021 1.00 27.65 C
ATOM 4459 CE2 TYR C 188 - 11.960 -17.577 - 34.408 1. .00 27.72 CATOM 4459 CE2 TYR C 188-11.960 -17.577-34.408 1. .00 27.72 C
ATOM 4460 CZ TYR C 188 -12.962 -17.133 - 35.246 1. .00 27.98 CATOM 4460 CZ TYR C 188 -12.962 -17.133-35.246 1. .00 27.98 C
ATOM 4461 OH TYR C 188 -13.969 -17.983 -35.636 1. .00 30.13 0ATOM 4461 OH TYR C 188 -13.969 -17.983 -35.636 1. .00 30.13 0
ATOM 4462 C TYR C 188 」9.099 -12.720 -32.387 1. .00 27.72 CATOM 4462 C TYR C 188 `` 9.099 -12.720 -32.387 1. .00 27.72 C
ATOM 4463 0 TYR C 188 -8.540 -11.918 -33.138 1, .00 27.66 0ATOM 4463 0 TYR C 188 -8.540 -11.918 -33.138 1, .00 27.66 0
ATOM 4464 N THR C 189 -8.700 - 12.935 -31.143 1, .00 26.62 NATOM 4464 N THR C 189 -8.700-12.935 -31.143 1, .00 26.62 N
ATOM 4465 CA THR C 189 -7.598 -12.186 - 30.566 1, .00 24.18 CATOM 4465 CA THR C 189 -7.598 -12.186-30.566 1, .00 24.18 C
ATOM 4466 CB THR C 189 -8.112 -11.201 -29.507 1 .00 23.65 CATOM 4466 CB THR C 189 -8.112 -11.201 -29.507 1 .00 23.65 C
ATOM 4467 0G1 THR c 189 - 7.001 -10.560 -28.868 1, .00 22.35 0ATOM 4467 0G1 THR c 189-7.001 -10.560 -28.868 1, .00 22.35 0
ATOM 4468 CG2 THR c 189 -8.958 -11.936 - 28.470 1 ,00 19.95 CATOM 4468 CG2 THR c 189 -8.958 -11.936-28.470 1, 00 19.95 C
ATOM 4469 C THR c 189 -6.593 -13.139 -29.923 1 .00 25.18 GATOM 4469 C THR c 189 -6.593 -13.139 -29.923 1 .00 25.18 G
ATOM 4470 0 THR c 189 -6.958 -14.228 -29.463 1 .00 23.94 0ATOM 4470 0 THR c 189 -6.958 -14.228 -29.463 1 .00 23.94 0
ATOM 4471 N ALA c 190 - 5.329 - 12.727 - 29.899 1 .00 23.95 NATOM 4471 N ALA c 190-5.329-12.727-29.899 1 .00 23.95 N
ATOM 4472 CA ALA c 190 -4.277 -13.544 - 29.308 1 .00 24.15 CATOM 4472 CA ALA c 190 -4.277 -13.544-29.308 1 .00 24.15 C
ATOM 4473 CB ALA c 190 -2.914 -13.129 -29.861 1 .00 19.04 CATOM 4473 CB ALA c 190 -2.914 -13.129 -29.861 1 .00 19.04 C
ATOM 4474 C ALA c 190 - 4.308 -13.392 -27.792 1 .00 24.34 CATOM 4474 C ALA c 190-4.308 -13.392 -27.792 1 .00 24.34 C
ATOM 4475 0 ALA c 190 - 3.838 -14.262一 27.057 1 .00 24.22 0 7071755 ATOM 4475 0 ALA c 190-3.838 -14.262 1 27.057 1 .00 24.22 0 7071755
ATOM 4476 N SER C 191 -4.870一 12. 283 -27.326 1. 00 25.74 NATOM 4476 N SER C 191 -4.870 One 12. 283 -27.326 1. 00 25.74 N
ATOM 4477 CA SER C 191 -5.093一 12, 107 -25.906 1. 00 26.50 CATOM 4477 CA SER C 191 -5.093 1 12, 107 -25.906 1. 00 26.50 C
ATOM 4478 CB SER C 191 - 3.800 -11. 680 - 25.226 1. 00 27.73 CATOM 4478 CB SER C 191-3.800 -11. 680-25.226 1. 00 27.73 C
ATOM 4479 OG SER C 191 - 3.963 -11. 713 -23.820 1. 00 29.83 0ATOM 4479 OG SER C 191-3.963 -11. 713 -23.820 1.00 29.83 0
ATOM 4480 C SER C 191 -6.195 -11. 114 -25.556 1. 00 26.09 CATOM 4480 C SER C 191 -6.195 -11. 114 -25.556 1. 00 26.09 C
ATOM 4481 0 SER C 191 -6.333 -10. 065 -26.177 1. 00 26.65 0ATOM 4481 0 SER C 191 -6.333 -10. 065 -26.177 1.00 26.65 0
ATOM 4482 N ILE C 192 -6.986 -11. 461 -24.552 1. 00 26.45 NATOM 4482 N ILE C 192 -6.986 -11. 461 -24.552 1. 00 26.45 N
ATOM 4483 CA ILE C 192 -7.792 -10. 477 -23.857 1. 00 25.80 CATOM 4483 CA ILE C 192 -7.792 -10.477 -23.857 1.00 25.80 C
ATOM 4484 CB ILE C 192 -9.132 - 11. 081 - 23.406 1. 00 26.75 CATOM 4484 CB ILE C 192 -9.132-11. 081-23.406 1.00 26.75 C
ATOM 4485 CG2 ILE C 192 -9.944 -10. 051 - 22.645 1. 00 26.09 CATOM 4485 CG2 ILE C 192 -9.944 -10. 051-22.645 1. 00 26.09 C
ATOM 4486 CG1 ILE C 192 -9.909 -11. 570 -24.628 1. 00 28.57 CATOM 4486 CG1 ILE C 192 -9.909 -11. 570 -24.628 1. 00 28.57 C
ATOM 4487 CD1 ILE C 192 -11.306 -12. 058 -24,319 1. 00 30.86 CATOM 4487 CD1 ILE C 192 -11.306 -12. 058 -24,319 1. 00 30.86 C
ATOM 4488 C ILE C 192 -6. 988 -10. 025 -22.642 1. 00 27.13 CATOM 4488 C ILE C 192 -6. 988 -10. 025 -22.642 1. 00 27.13 C
ATOM 4489 0 ILE C 192 -6. 757 -10. 813 -21.723 1. 00 25.62 0ATOM 4489 0 ILE C 192 -6. 757 -10. 813 -21.723 1. 00 25.62 0
ATOM 4490 N ASP C 193 -6. 545 -8. 766 -22.651 1. 00 26.19 NATOM 4490 N ASP C 193 -6. 545 -8. 766 -22.651 1. 00 26.19 N
ATOM 4491 CA ASP C 193 -5. 728 -8. 240 -21.562 1. 00 27.79 CATOM 4491 CA ASP C 193 -5. 728 -8. 240 -21.562 1. 00 27.79 C
ATOM 4492 CB ASP C 193 一 4. 714 -7. 208 -22.105 1. 00 29.15 CATOM 4492 CB ASP C 193 One 4. 714 -7. 208 -22.105 1. 00 29.15 C
ATOM 4493 C6 ASP C 193 -3. 556 -7. 861 -22.892 1. , 00 33.51 CATOM 4493 C6 ASP C 193 -3. 556 -7. 861 -22.892 1., 00 33.51 C
ATOM 4494 0D1 ASP C 193 -3. 585 - 9. Q96 - 23.103 1. , 00 34.53 0ATOM 4494 0D1 ASP C 193 -3. 585-9. Q96-23.103 1., 00 34.53 0
ATOM 4495 0D2 ASP C 193 - 2. 607 -7. 146 -23.302 1. , 00 32.06 0ATOM 4495 0D2 ASP C 193-2. 607 -7. 146 -23.302 1., 00 32.06 0
ATOM 4496 C ASP C 193 -6. 597 - 7. 627 -20.453 1, .00 28.98 CATOM 4496 C ASP C 193 -6. 597-7. 627 -20.453 1, .00 28.98 C
ATOM 4497 0 ASP C 193 -7. 816 - 7. 815 -20.433 1. .00 25.42 0ATOM 4497 0 ASP C 193 -7. 816-7. 815 -20.433 1. .00 25.42 0
ATOM 4498 N GLN C 194 5. 970 -6. 907 - 19.524 1. .00 29.98 NATOM 4498 N GLN C 194 5. 970 -6. 907-19.524 1. .00 29.98 N
ATOM 4499 CA 6LN C 194 -6. 652 - 6. 479 -18.311 1. ■ 00 32.59 CATOM 4499 CA 6LN C 194 -6. 652-6. 479 -18.311 1. ■ 00 32.59 C
ATOM 4500 CB GLN c 194 -5. 635 - 6. 148 - 17.221 1, .00 36.97 CATOM 4500 CB GLN c 194 -5. 635-6. 148-17.221 1, .00 36.97 C
ATOM 4501 C6 GLN c 194 —4. 466 - 7. 110 -17.135 1, .0040.66 CATOM 4501 C6 GLN c 194 —4. 466-7. 110 -17.135 1, .0040.66 C
ATOM 4502 CD GLN c 194 - 3. 293 -6. 490 -16.406 1 • 0043.66 CATOM 4502 CD GLN c 194-3. 293 -6. 490 -16.406 1 • 0043.66 C
ATOM 4503 0E1 GLN c 194 - 3. 454 - 5. 498 -15.697 1 .0046.94 0ATOM 4503 0E1 GLN c 194-3. 454-5. 498 -15.697 1 .0046.94 0
ATOM 4504 NE2 GLN c 194 - 2. 106 -7. 062 -16.580 1 .00 45.22 NATOM 4504 NE2 GLN c 194-2. 106 -7. 062 -16.580 1 .00 45.22 N
ATOM 4505 C GLN c 194 - 7. 534 -5. 262 -18.564 1 .00 32.70 CATOM 4505 C GLN c 194-7. 534 -5. 262 -18.564 1 .00 32.70 C
ATOM 4506 0 GLN c 194 -8. 709 - 5. 259 -18.203 1 .0031.90 0ATOM 4506 0 GLN c 194 -8. 709-5. 259 -18.203 1 .0031.90 0
ATOM 4507 N GLY c 195 - 6. 964 一 4. 231 -19.188 1 • 00 33.36 NATOM 4507 N GLY c 195-6. 964 one 4. 231 -19.188 1 • 00 33.36 N
ATOM 4508 CA 6LY c 195 - 7. 745 - 3. 058 -19.554 1 .00 32.42 CATOM 4508 CA 6LY c 195-7. 745-3. 058 -19.554 1 .00 32.42 C
ATOM 4509 C GLY c 195 -6. 901 - 1. 928 -20.117 1 .00 33.18 CATOM 4509 C GLY c 195 -6. 901-1. 928 -20.117 1 .00 33.18 C
ATOM 4510 0 GLY c 195 -5. 836 -2. 159 -20.700 1 .00 31.49 0ATOM 4510 0 GLY c 195 -5. 836 -2. 159 -20.700 1 .00 31.49 0
ATOM 4511 N LEU c 196 一 7. 383 一 0. 698 -19.952 1 ■ 00 34.49 N TJP2007/071755 ATOM 4511 N LEU c 196 1 7. 383 1 0. 698 -19.952 1 ■ 00 34.49 N TJP2007 / 071755
ATOM 4512 CA LEU C 196 -6. 630 0.488 -20.360 1. 00 35.38 CATOM 4512 CA LEU C 196 -6. 630 0.488 -20.360 1. 00 35.38 C
ATOM 4513 CB LEU C 196 -7. 512 1.414 -21.201 1. 00 34.52 CATOM 4513 CB LEU C 196 -7. 512 1.414 -21.201 1.00 34.52 C
ATOM 4514 CG LEU C 196 - 8. 229 0.797 -22.406 1. 00 35.17 CATOM 4514 CG LEU C 196-8. 229 0.797 -22.406 1. 00 35.17 C
ATOM 4515 CD1 LEU C 196 - 9. 026 1.864 -23.140 1. 00 34.81 CATOM 4515 CD1 LEU C 196-9. 026 1.864 -23.140 1.00 34.81 C
ATOM 4516 CD2 LEU C 196 -7. 211 0.173 -23.339 1. 00 33.76 CATOM 4516 CD2 LEU C 196 -7. 211 0.173 -23.339 1. 00 33.76 C
ATOM 4517 C LEU G 196 -6. 127 1.239 -19.130 1. 00 37.71 CATOM 4517 C LEU G 196 -6. 127 1.239 -19.130 1.00 37.71 C
ATOM 4518 0 LEU C 196 -6. 774 1.234 -18.082 1. 00 39.90 0ATOM 4518 0 LEU C 196 -6.774 1.234 -18.082 1.00 39.90 0
ATOM 4519 N ASN C 197 -4. 969 1.877 - 19.250 1. 00 39.14 NATOM 4519 N ASN C 197 -4. 969 1.877-19.250 1.00 39.14 N
ATOM 4520 CA ASN C 197 - 4, 465 2.716 -18.170 1. 00 40.85 CATOM 4520 CA ASN C 197-4, 465 2.716 -18.170 1. 00 40.85 C
ATOM 4521 CB ASN C 197 -2.937 2.607 -18.059 1. 00 40.32 CATOM 4521 CB ASN C 197 -2.937 2.607 -18.059 1.00 40.32 C
ATOM 4522 CG ASN C 197 -2.220 3.006 -19.336 1. 00 38.92 CATOM 4522 CG ASN C 197 -2.220 3.006 -19.336 1. 00 38.92 C
ATOM 4523 0D1 ASN C 197 -2.802 3.620 -20.228 1. 00 40.72 0ATOM 4523 0D1 ASN C 197 -2.802 3.620 -20.228 1.00 40.72 0
ATOM 4524 ND2 ASN C 197 - 0.948 2.655 -19.428 1. 00 38.19 NATOM 4524 ND2 ASN C 197-0.948 2.655 -19.428 1. 00 38.19 N
ATOM 4525 C ASN G 197 - 4.868 4.163 -18.403 1. 00 42.72 CATOM 4525 C ASN G 197-4.868 4.163 -18.403 1. 00 42.72 C
ATOM 4526 0 ASN C 197 -5.573 4.473 -19.368 1. 00 43.39 0ATOM 4526 0 ASN C 197 -5.573 4.473 -19.368 1. 00 43.39 0
ATOM 4527 N GLU C 198 - 4.428 5.049 -17.516 1. 00 44.83 NATOM 4527 N GLU C 198-4.428 5.049 -17.516 1.00 44.83 N
ATOM 4528 CA GLU C 198 - 4.748 6.467 -17.648 1. 00 46.65 CATOM 4528 CA GLU C 198-4.748 6.467 -17.648 1. 00 46.65 C
ATOM 4529 CB GLU C 198 -3.946 7.292 - 16.636 1. 00 48.31 CATOM 4529 CB GLU C 198 -3.946 7.292-16.636 1. 00 48.31 C
ATOM 4530 C6 GLU C 198 —4. 502 7.257 -15.219 1. .00 51.45 CATOM 4530 C6 GLU C 198 —4. 502 7.257 -15.219 1. .00 51.45 C
ATOM 4531 CD GLU C 198 -3. 823 8.264 -14.299 1. ,00 53.88 CATOM 4531 CD GLU C 198 -3. 823 8.264 -14.299 1., 00 53.88 C
ATOM 4532 0E1 GLU C 198 -2. 577 8.195 -14.153 1. .00 52.20 0ATOM 4532 0E1 GLU C 198 -2. 577 8.195 -14.153 1. .00 52.20 0
ATOM 4533 0E2 GLU C 198 -4. 536 9.124 -13.730 1. .00 52.91 0ATOM 4533 0E2 GLU C 198 -4. 536 9.124 -13.730 1. .00 52.91 0
ATOM 4534 C GLU G 198 -4. 452 6.960 -19.061 1, .00 46.03 CATOM 4534 C GLU G 198 -4. 452 6.960 -19.061 1, .00 46.03 C
ATOM ' 4535 0 GLU C 198 - 5. 229 7.718 -19.645 1. .00 46.26 0ATOM '4535 0 GLU C 198-5. 229 7.718 -19.645 1. .00 46.26 0
ATOM 4536 N HIS C 199 -3. 332 6.511 -19.614 1. .00 44.73 : NATOM 4536 N HIS C 199 -3. 332 6.511 -19.614 1. .00 44.73 : N
ATOM 4537 CA HIS C 199 - 2. 902 6.982 -20.922 1. .00 44.02 CATOM 4537 CA HIS C 199-2. 902 6.982 -20.922 1. .00 44.02 C
ATOM 4538 CB HIS C 199 -1. 373 6.959 - 20.996 1, .00 44.48 CATOM 4538 CB HIS C 199 -1. 373 6.959-20.996 1, .00 44.48 C
ATOM 4539 CG HIS C 199 - 0· 719 7.947 -20.080 1, .00 46.52 CATOM 4539 CG HIS C 199-0 719 7.947 -20.080 1, .00 46.52 C
ATOM 4540 CD2 HIS C 199 - 0. 532 9.282 -20.199 1, .00 46.06 CATOM 4540 CD2 HIS C 199-0. 532 9.282 -20.199 1, .00 46.06 C
ATOM 4541 ND1 HIS C 199 -0. 169 7.590 - 18.867 1, .00 46.57 NATOM 4541 ND1 HIS C 199 -0. 169 7.590-18.867 1, .00 46.57 N
ATOM 4542 CE1 HIS G 199 0. 332 8.662 - 18.280 1 .00 45.56 CATOM 4542 CE1 HIS G 199 0. 332 8.662-18.280 1 .00 45.56 C
ATOM 4543 NE2 HIS C 199 0. 125 9.702 -19.067 1 .00 47.23 NATOM 4543 NE2 HIS C 199 0. 125 9.702 -19.067 1 .00 47.23 N
ATOM 4544 C HIS C 199 - 3. 512 6.201 -22.084 1 • 00 41.62 CATOM 4544 C HIS C 199-3. 512 6.201 -22.084 1 • 00 41.62 C
ATOM 4545 0 HIS C 199 -3. 111 6.371 -23.237 1 .00 39.89 0ATOM 4545 0 HIS C 199 -3. 111 6.371 -23.237 1 .00 39.89 0
ATOM 4546 N 6LY C 200 一 4. 487 5.349 -21.776 1 • 00 41.15 NATOM 4546 N 6LY C 200 One 4. 487 5.349 -21.776 1 • 00 41.15 N
ATOM 4547 CA GLY C 200 -5. 238 4.677 -22.822 1 .00 38.02 C P T/JP2007/071755 ATOM 4547 CA GLY C 200 -5. 238 4.677 -22.822 1 .00 38.02 C PT / JP2007 / 071755
ATOM 4548 C 6LY C 200 -4.486 3.542 -23.491 1. 00 37.35 CATOM 4548 C 6LY C 200 -4.486 3.542 -23.491 1. 00 37.35 C
ATOM 4549 0 GLY G 200 -4.789 . 3.179 -24.628 1. 00 36.72 0ATOM 4549 0 GLY G 200 -4.789. 3.179 -24.628 1. 00 36.72 0
ATOM 4550 N TYR C 201 -3.500 2.984 -22.794 1. 00 35.34 ΝATOM 4550 N TYR C 201 -3.500 2.984 -22.794 1.00 35.34 Ν
ATOM 4551 CA TYR C 201 -2.760 1.834 -23.306 1. 00 33.14 CATOM 4551 CA TYR C 201 -2.760 1.834 -23.306 1. 00 33.14 C
ATOM 4552 CB TYR C 201 -1.311 1.867 -22.837 1. 00 34.62 CATOM 4552 CB TYR C 201 -1.311 1.867 -22.837 1.00 34.62 C
ATOM 4553 CG TYR C 201 -0.413 2.775 - 23.636 1. 00 37.75 CATOM 4553 CG TYR C 201 -0.413 2.775-23.636 1.00 37.75 C
ATOM 4554 CD1 TYR C 201 0.061 3.964 -23.095 1. 00 36.66 CATOM 4554 CD1 TYR C 201 0.061 3.964 -23.095 1. 00 36.66 C
ATOM 4555 CE1 TYR C 201 0.928 4.770 -23.800 1. 00 38.34 CATOM 4555 CE1 TYR C 201 0.928 4.770 -23.800 1.00 38.34 C
ATOM 4556 GD2 TYR C 201 0.002 2.419 - 24.912 1. 00 36.54 CATOM 4556 GD2 TYR C 201 0.002 2.419-24.912 1. 00 36.54 C
ATOM 4557 CE2 TYR G 201 0.869 3.214 -25.623 1. 00 39.77 CATOM 4557 CE2 TYR G 201 0.869 3.214 -25.623 1. 00 39.77 C
ATOM 4558 CZ TYR C 201 1.333 4.390 - 25.063 1. 00 40.01 G ATOM 4558 CZ TYR C 201 1.333 4.390-25.063 1.00 40.01 G
I I
ATOM 4559 ,0H TYR C 201 2.222 5.173 - 25.764 1. 00 39.10 0ATOM 4559, 0H TYR C 201 2.222 5.173-25.764 1.00 39.10 0
ATOM 4560 C TYR C 201 - 3.384 0.550 -22.814 1. 00 31.82 C ATOM 4560 C TYR C 201-3.384 0.550 -22.814 1.00 31.82 C
I I
ATOM 4561 0 TYR C 201 - 3.833 0.463 -21.677 1. 00 32.28 0ATOM 4561 0 TYR C 201-3.833 0.463 -21.677 1. 00 32.28 0
ATOM 4562 N ILE C 202 -3.399 - 0· 461 -23.66 017 1. 00 30.54 ΝATOM 4562 N ILE C 202 -3.399-0 461 -23.66 017 1. 00 30.54 Ν
ATOM 4563 CA ILE C 202 -3.791 -23.217 1. 00 29.03 CATOM 4563 CA ILE C 202 -3.791 -23.217 1. 00 29.03 C
ATOM 4564 CB ILE C 202 -3.984 - 2.714 -24.407 1. 00 25.29 CATOM 4564 CB ILE C 202 -3.984-2.714 -24.407 1. 00 25.29 C
ATOM 4565 CG2 ILE C 202 - 4.472 -4.070 -23.935 1. ,00 24.77 CATOM 4565 CG2 ILE C 202-4.472 -4.070 -23.935 1., 00 24.77 C
ATOM 4566 CG1 ILE C 202 - 4.998 -2.100 -25.361 1. .00 21.50 CATOM 4566 CG1 ILE C 202-4.998 -2.100 -25.361 1. .00 21.50 C
ATOM 4567 CD1 ILE C 202 - 5.431 -3.022 -26.466 1. ,00 23.65 CATOM 4567 CD1 ILE C 202-5.431 -3.022 -26.466 1., 00 23.65 C
ATOM 4568 C ILE C 202 -2.708 -2.324 -22.287 1. .00 29.20 CATOM 4568 C ILE C 202 -2.708 -2.324 -22.287 1. .00 29.20 C
ATOM 4569 0 ILE C 202 -1.521 - 2.224 - 22.581 1. .00 29.41 0ATOM 4569 0 ILE C 202 -1.521-2.224-22.581 1. .00 29.41 0
ATOM 4570 N ILE C 203 3.125 - 2.867 1. .00 29.54 ΝATOM 4570 N ILE C 203 3.125-2.867 1. .00 29.54 Ν
ATOM 4571 CA ILE C 203 - 2.202 -3.469 -20.197 1. .00 29.83 CATOM 4571 CA ILE C 203-2.202 -3.469 -20.197 1. .00 29.83 C
ATOM 4572 CB ILE C 203 -2.323 -2.818 -18.795 1. .00 29.18 CATOM 4572 CB ILE C 203 -2.323 -2.818 -18.795 1. .00 29.18 C
ATOM 4573 CG2 ILE c 203 -1■ 288 - 3.426 - 17.850 1. .00 29.42 CATOM 4573 CG2 ILE c 203 -1 288-3.426-17.850 1. .00 29.42 C
ATOM 4574 CG1 ILE c 203 - 2.108 - 1.303 - 18.889 1. .00 27.64 CATOM 4574 CG1 ILE c 203-2.108-1.303-18.889 1. .00 27.64 C
ATOM 4575 CD1 ILE c 203 -0.700 -0.889 - 19.266 1. .00 25.55 CATOM 4575 CD1 ILE c 203 -0.700 -0.889-19.266 1. .00 25.55 C
ATOM 4576 C ILE c 203 -2.561 -4.946 - 20.075 1. .00 31.46 CATOM 4576 C ILE c 203 -2.561 -4.946-20.075 1. .00 31.46 C
ATOM 4577 0 ILE c 203 -3.736 -5.299 -19.966 1' .00 30.30 0ATOM 4577 0 ILE c 203 -3.736 -5.299 -19.966 1 '.00 30.30 0
ATOM 4578 N PRO G 204 -1.553 -5.832 -20.107 1 .00 33.17 ΝATOM 4578 N PRO G 204 -1.553 -5.832 -20.107 1 .00 33.17 Ν
ATOM 4579 CD PRO C 204 -1.757 -7.280 -19.926 1 .00 33.54 CATOM 4579 CD PRO C 204 -1.757 -7.280 -19.926 1 .00 33.54 C
ATOM 4580 CA PRO C 204 -0.141 - 5.501 - 20.341 1 ■ 00 33.07 CATOM 4580 CA PRO C 204 -0.141-5.501-20.341 1 ∎ 00 33.07 C
ATOM 4581 CB PRO C 204 0.585 -6.825 - 20.121 1 ■ 00 32.47 CATOM 4581 CB PRO C 204 0.585 -6.825-20.121 1 ∎ 00 32.47 C
ATOM 4582 CG PRO c 204 - 0.457 - 7.866 - 20.384 1 ■ 00 33.71 CATOM 4582 CG PRO c 204-0.457-7.866-20.384 1 ■ 00 33.71 C
ATOM 4583 C PRO c 204 0.112 -4.942 -21.737 1 ■ 00 32.91 C 5 ATOM 4583 C PRO c 204 0.112 -4.942 -21.737 1 ∎ 00 32.91 C Five
ATOM 4584 0 PRO C 204 1. 050 -4.172 -21.943 1. 00 34.00 0ATOM 4584 0 PRO C 204 1. 050 -4.172 -21.943 1. 00 34.00 0
ATOM 4585 N 6LY C 205 -0.723 - 5.339 -22.691 1. 00 31.15 NATOM 4585 N 6LY C 205 -0.723-5.339 -22.691 1.00 31.15 N
ATOM 4586 CA GLY C 205 -0.648 -4.767 -24.024 1. 00 31.26 CATOM 4586 CA GLY C 205 -0.648 -4.767 -24.024 1. 00 31.26 C
ATOM 4587 C GLY C 205 0.727 - 4.829 -24.663 1. 00 29.91 CATOM 4587 C GLY C 205 0.727-4.829 -24.663 1. 00 29.91 C
ATOM 4588 0 GLY C 205 1. 581 -5.591 - 24.225 1. 00 30.07 0ATOM 4588 0 GLY C 205 1. 581 -5.591-24.225 1.00 30.07 0
ATOM 4589 N LEU C 206 0.941 -4.012 -25.693 1. 00 29.65 NATOM 4589 N LEU C 206 0.941 -4.012 -25.693 1. 00 29.65 N
ATOM 4590 CA LEU C 206. 2.153 - 4.081 -26.500 1. 00 28.23 CATOM 4590 CA LEU C 206. 2.153-4.081 -26.500 1. 00 28.23 C
ATOM 4591 CB LEU C 206 1. 819 -4.638 -27.880 1. 00 25.50 CATOM 4591 CB LEU C 206 1. 819 -4.638 -27.880 1. 00 25.50 C
ATOM 4592 C6 LEU C 206 1. 179 - 6.023 -27.912 1. 00 24.15 CATOM 4592 C6 LEU C 206 1. 179-6.023 -27.912 1. 00 24.15 C
ATOM 4593 CD1 LEU C 206 0. 640 - 6.291 -29.296 1. 00 23.53 CATOM 4593 CD1 LEU C 206 0. 640-6.291 -29.296 1. 00 23.53 C
ATOM 4594 CD2 LEU C 206 2. 197 - 7.075 -27.511 1. 00 24.08 CATOM 4594 CD2 LEU C 206 2. 197-7.075 -27.511 1. 00 24.08 C
ATOM 4595 ,C LEU C 206 2. 867 -2.734 -26.663 1. 00 28.36 CATOM 4595, C LEU C 206 2. 867 -2.734 -26.663 1. 00 28.36 C
ATOM 4596 0 LEU C 206 3. 912 -2.657 -27.306 1. 00 28.53 0ATOM 4596 0 LEU C 206 3. 912 -2.657 -27.306 1. 00 28.53 0
ATOM 4597 N GLY C 207 2. 304 - 1.676 -26.092 1. 00 27.75 NATOM 4597 N GLY C 207 2. 304-1.676 -26.092 1. 00 27.75 N
ATOM 4598 CA GLY C 207 2. 877 -0.358 -26.285 1. 00 24.98 C ATOM 4598 CA GLY C 207 2. 877 -0.358 -26.285 1.00 24.98 C
o  o
ATOM 4599 C GLY C 207 2. 507 0.222 -27.637 1. 00 25.89 C ATOM 4599 C GLY C 207 2. 507 0.222 -27.637 1. 00 25.89 C
ATOM 4600 0 GLY C 207 1. 457 - 0.096 -28.191 1. 00 25.13 0ATOM 4600 0 GLY C 207 1. 457-0.096 -28.191 1. 00 25.13 0
ATOM 4601 N ASP C 208 3. 372 1.075 -28.176 1. 00 26.13 NATOM 4601 N ASP C 208 3. 372 1.075 -28.176 1. 00 26.13 N
ATOM 4602 CA ASP C 208 3. 110 1.709 -29.460 1. 00 26.85 CATOM 4602 CA ASP C 208 3. 110 1.709 -29.460 1.00 26.85 C
ATOM 4603 CB ASP C 208 4. 001 2.943 -29.626 1. 00 29.71 CATOM 4603 CB ASP C 208 4. 001 2.943 -29.626 1. 00 29.71 C
ATOM 4604 CG ASP C 208 3. 769 3.973 -28.544 1. ,00 32.90 CATOM 4604 CG ASP C 208 3. 769 3.973 -28.544 1., 00 32.90 C
ATOM 4605 0D1 ASP C 208 2. 593 4.356 - 28.344 1. ,00 36.64 0ATOM 4605 0D1 ASP C 208 2. 593 4.356-28.344 1., 00 36.64 0
ATOM 4606 0D2 ASP c 208 4. 752 4.396 -27.889 1. ,00 34.46 0ATOM 4606 0D2 ASP c 208 4.752 4.396 -27.889 1., 00 34.46 0
ATOM 4607 C ASP c 208 3. 381 0.732 -30.590 1. .00 26.52 CATOM 4607 C ASP c 208 3. 381 0.732 -30.590 1. .00 26.52 C
ATOM 4608 0 ASP c 208 4.445 0.782 -31.219 1. .00 26.14 0ATOM 4608 0 ASP c 208 4.445 0.782 -31.219 1. .00 26.14 0
ATOM 4609 N ALA c 209 2. 416 -0.146 -30.855 1. .00 25.74 NATOM 4609 N ALA c 209 2. 416 -0.146 -30.855 1. .00 25.74 N
ATOM 4610 CA ALA c 209 2. 592 -1.204 1. .00 26.00 CATOM 4610 CA ALA c 209 2. 592 -1.204 1. .00 26.00 C
ATOM 4611 CB ALA c 209 1. 402 -2.166 - 31.820 1. .00 26.00 CATOM 4611 CB ALA c 209 1. 402 -2.166-31.820 1. .00 26.00 C
ATOM 4612 C ALA c 209 2. 760 -0.625 -33.253 1. , 00 25.61 CATOM 4612 C ALA c 209 2. 760 -0.625 -33.253 1., 00 25.61 C
ATOM 4613 0 ALA c 209 3. 491 - 1.171 -34.083 1, .00 26.24 0ATOM 4613 0 ALA c 209 3. 491-1.171 -34.083 1, .00 26.24 0
ATOM 4614 N GLY c 210 2. 079 0.480 -33.514 1, .00 24.47 NATOM 4614 N GLY c 210 2. 079 0.480 -33.514 1, .00 24.47 N
ATOM 4615 CA GLY c 210 2. 283 1.175 - 34.770 1, .00 23.64 CATOM 4615 CA GLY c 210 2. 283 1.175-34.770 1, .00 23.64 C
ATOM 4616 C GLY c 210 3. 739 1.541 - 34.985 1, .00 24.35 CATOM 4616 C GLY c 210 3. 739 1.541-34.985 1, .00 24.35 C
ATOM 4617 0 GLY c 210 4. 315 1.234 -36.032 1, .00 24.94 0ATOM 4617 0 GLY c 210 4. 315 1.234 -36.032 1, .00 24.94 0
ATOM 4618 N ASP c 211 4. 350 2.187 -33.998 1 .00 24.43 NATOM 4618 N ASP c 211 4. 350 2.187 -33.998 1 .00 24.43 N
ATOM 4619 CA ASP c 211 5. 726 2.645 -34.156 1 .00 28.14 C P2007/071755 ATOM 4619 CA ASP c 211 5. 726 2.645 -34.156 1 .00 28.14 C P2007 / 071755
ATOM 4620 CB ASP C 211 6.085 3.643 - 33.048 1. 00 30.16 CATOM 4620 CB ASP C 211 6.085 3.643-33.048 1. 00 30.16 C
ATOM 4621 CG ASP C 211 5.431 5.003 -33.254 1. 00 34.51 CATOM 4621 CG ASP C 211 5.431 5.003 -33.254 1.00 34.51 C
ATOM 4622 0D1 ASP C 211 5.062 5.333 -34.405 1. 00 32.30 0ATOM 4622 0D1 ASP C 211 5.062 5.333 -34.405 1.00 32.30 0
ATOM 4623 0D2 ASP C 211 5.289 5. 742 -32.258 1. 00 37.23 0ATOM 4623 0D2 ASP C 211 5.289 5. 742 -32.258 1. 00 37.23 0
ATOM 4624 C ASP C 211 6.743 1. 496 -34.176 1. 00 28.21 CATOM 4624 C ASP C 211 6.743 1. 496 -34.176 1. 00 28.21 C
ATOM 4625 0 ASP C 211 7.724 1. 547 -34.913 1. 00 28.65 0ATOM 4625 0 ASP C 211 7.724 1. 547 -34.913 1. 00 28.65 0
ATOM 4626 N LYS C 212 6.500 0.462 -33.375 1. 00 27.03 NATOM 4626 N LYS C 212 6.500 0.462 -33.375 1. 00 27.03 N
ATOM 4627 CA LYS C 212 7.403 -0.682 -33.312 1. 00 26.65 CATOM 4627 CA LYS C 212 7.403 -0.682 -33.312 1. 00 26.65 C
ATOM 4628 CB LYS C 212 7.076 - 1. 542 -32.092 1. 00 25.83 CATOM 4628 CB LYS C 212 7.076-1. 542 -32.092 1. 00 25.83 C
ATOM 4629 CG LYS C 212 7.376 -0.866 -30.768 1. 00 26.73 CATOM 4629 CG LYS C 212 7.376 -0.866 -30.768 1.00 26.73 C
ATOM 4630 CD LYS C 212 6.463 -1. 403 -29.691 1. 00 28.40 CATOM 4630 CD LYS C 212 6.463 -1. 403 -29.691 1. 00 28.40 C
ATOM 4631 CE LYS C 212 7.196 - 1. 612 -28.396 1. 00 30.58 CATOM 4631 CE LYS C 212 7.196-1. 612 -28.396 1. 00 30.58 C
ATOM 4632 NZ LYS C 212 6.306 - 2. 296 -27.428 1. 00 32.71 NATOM 4632 NZ LYS C 212 6.306-2. 296 -27.428 1. 00 32.71 N
ATOM 4633 C LYS C 212 7.356 - 1. 551 -34.568 1. 00 26.39 CATOM 4633 C LYS C 212 7.356-1. 551 -34.568 1. 00 26.39 C
ATOM 4634 0 LYS C 212 8.314 -2. 260 -34.875 1. 00 30.24 0ATOM 4634 0 LYS C 212 8.314 -2. 260 -34.875 1. 00 30.24 0
ATOM 4635 N ILE C 213 6.241 - 1. 514 - 35.288 1. 00 24.71 NATOM 4635 N ILE C 213 6.241-1. 514-35.288 1. 00 24.71 N
ATOM 4636 CA ILE C 213 6.182 -2. 178 -36.579 1. 00 22.79 CATOM 4636 CA ILE C 213 6.182 -2. 178 -36.579 1. 00 22.79 C
ATOM 4637 CB ILE C 213 4.736 -2. 442 -37.021 1. 00 22.33 CATOM 4637 CB ILE C 213 4.736 -2. 442 -37.021 1. 00 22.33 C
ATOM 4638 CG2 ILE C 213 4.710 - 2. 831 -38.483 1. ,00 21.68 CATOM 4638 CG2 ILE C 213 4.710-2. 831 -38.483 1., 00 21.68 C
ATOM 4639 CG1 ILE C 213 4.115 - 3. 536 - 36.152 1. .00 23.48 CATOM 4639 CG1 ILE C 213 4.115-3. 536-36.152 1. .00 23.48 C
ATOM 4640 CD1 ILE C 213 2.638 - 3. 761 -36.402 1. .00 19.37 CATOM 4640 CD1 ILE C 213 2.638-3. 761 -36.402 1. .00 19.37 C
ATOM 4641 C ILE C 213 6.873 -1. 354 -37.657 1. .00 22.94 CATOM 4641 C ILE C 213 6.873 -1. 354 -37.657 1. .00 22.94 C
ATOM 4642 0 ILE C 213 7.600 - 1. 891 -38.484 1, ,00 22.68 0ATOM 4642 0 ILE C 213 7.600-1. 891 -38.484 1,, 00 22.68 0
ATOM 4643 N PHE C 214 6.653 - 0. 044一 37.641 1. .00 23.27 NATOM 4643 N PHE C 214 6.653-0. 044 1 37.641 1. .00 23.27 N
ATOM 4644 CA PHE c 214 7.186 0. 822 -38.684 1. .00 23.12 CATOM 4644 CA PHE c 214 7.186 0. 822 -38.684 1. .00 23.12 C
ATOM 4645 CB PHE c 214 6.182 1. 942 -38.986 1. .00 24.23 CATOM 4645 CB PHE c 214 6.182 1. 942 -38.986 1. .00 24.23 C
ATOM 4646 CG PHE c 214 4.999 1. 480 -39.795 1, .00 26.78 CATOM 4646 CG PHE c 214 4.999 1. 480 -39.795 1, .00 26.78 C
ATOM 4647 CD1 PHE c 214 4.845 1. 880 -41.117 1, .00 25.91 CATOM 4647 CD1 PHE c 214 4.845 1. 880 -41.117 1, .00 25.91 C
ATOM 4648 CD2 PHE G 214 4.073 0. 590 - 39.254 1, .00 27.24 CATOM 4648 CD2 PHE G 214 4.073 0. 590-39.254 1, .00 27.24 C
ATOM 4649 CE1 PHE C 214 3.788 1. 399 - 41■ 892 1, .00 26.17 GATOM 4649 CE1 PHE C 214 3.788 1. 399-41 ■ 892 1, .00 26.17 G
ATOM 4650 CE2 PHE C 214 3.012 0. 102 - 40.024 1, .00 27.67 CATOM 4650 CE2 PHE C 214 3.012 0. 102-40.024 1, .00 27.67 C
ATOM 4651 CZ PHE C 214 2.875 0. 510 -41.346 1, .00 27.64 CATOM 4651 CZ PHE C 214 2.875 0. 510 -41.346 1, .00 27.64 C
ATOM 4652 C PHE G 214 8.557 1. 403 -38.341 1, .00 23.43 CATOM 4652 C PHE G 214 8.557 1. 403 -38.341 1, .00 23.43 C
ATOM 4653 0 PHE C 214 9.233 1. 959 - 39.202 1 .00 20.52 0ATOM 4653 0 PHE C 214 9.233 1. 959-39.202 1 .00 20.52 0
ATOM 4654 N 6LY C 215 8.956 1. ,268 -37.080 1 .00 21.92 NATOM 4654 N 6LY C 215 8.956 1., 268 -37.080 1 .00 21.92 N
ATOM 4655 CA GLY C 215 10.278 1. , 699 -36.661 1 ■ 00 25.47 C ATOM 4656 C GLY C 215 10.354 3.200 -36.477 1.00 28.04 CATOM 4655 CA GLY C 215 10.278 1., 699 -36.661 1 ∎ 00 25.47 C ATOM 4656 C GLY C 215 10.354 3.200 -36.477 1.00 28.04 C
ATOM 4657 0 GLY C 215 11.384 3.814 -36. 738 1.00 26.42 0ATOM 4657 0 GLY C 215 11.384 3.814 -36. 738 1.00 26.42 0
ATOM 4658 N THR C 216 9.256 3.793 -36. 029 1.00 31.50 NATOM 4658 N THR C 216 9.256 3.793 -36. 029 1.00 31.50 N
ATOM 4659 CA THR C 216 9.148 5.242 -35. 953 1.00 35.50 CATOM 4659 CA THR C 216 9.148 5.242 -35. 953 1.00 35.50 C
ATOM 4660 CB THR C 216 7.922 5.747 -36. 729 1.00 34.44 CATOM 4660 CB THR C 216 7.922 5.747 -36.729 1.00 34.44 C
ATOM 4661 0G1 THR C 216 6.763 5.016 -36. 311 1.00 34.87 0ATOM 4661 0G1 THR C 216 6.763 5.016 -36. 311 1.00 34.87 0
ATOM 4662 CG2 THR C 216 8.121 5.567 -38. 222 1.00 35.57 CATOM 4662 CG2 THR C 216 8.121 5.567 -38. 222 1.00 35.57 C
ATOM 4663 C THR C 216 9.060 5.754 -34. 523 1.00 39.59 CATOM 4663 C THR C 216 9.060 5.754 -34. 523 1.00 39.59 C
ATOM 4664 0 THR C 216 9, 479 5.082 -33. 580 1.00 39.66 0ATOM 4664 0 THR C 216 9, 479 5.082 -33. 580 1.00 39.66 0
ATOM 4665 N LYS C 217 8.506 6.952 -34. 375 1.00 44.74 NATOM 4665 N LYS C 217 8.506 6.952 -34. 375 1.00 44.74 N
ATOM 4666 GA LYS C 217 8.635 7.719 - 33. 141 1.00 49.83 CATOM 4666 GA LYS C 217 8.635 7.719-33. 141 1.00 49.83 C
ATOM 4667 CB LYS C 217 9.505 8.960 - 33. 387 1.00 51.54 CATOM 4667 CB LYS C 217 9.505 8.960-33. 387 1.00 51.54 C
ATOM 4668 CG LYS C 217 10.830 8.682 -34. 095 1.00 52.81 CATOM 4668 CG LYS C 217 10.830 8.682 -34. 095 1.00 52.81 C
ATOM 4669 CD LYS C 217 10.640 8.477 -35. 601 1.00 52.85 CATOM 4669 CD LYS C 217 10.640 8.477 -35. 601 1.00 52.85 C
ATOM 4670 CE LYS C 217 11.949 8.078 -36. 283 1.00 53.43 GATOM 4670 CE LYS C 217 11.949 8.078 -36.283 1.00 53.43 G
ATOM 4671 NZ LYS C 217 12.569 6.847一 35. 697 1.00 53.76 NATOM 4671 NZ LYS C 217 12.569 6.847 1 35. 697 1.00 53.76 N
ATOM 4672 C LYS C 217 7.271 8.145 -32. 590 1.00 51.54 GATOM 4672 C LYS C 217 7.271 8.145 -32. 590 1.00 51.54 G
ATOM 4673 0 LYS C 217 7.032 7.932 -31. 380 1.00 52.97 0ATOM 4673 0 LYS C 217 7.032 7.932 -31. 380 1.00 52.97 0
ATOM 4674 OXT LYS c 217 6.464 8.698 -33. 368 1.00 52.31 0ATOM 4674 OXT LYS c 217 6.464 8.698 -33. 368 1.00 52.31 0
TER 4675 LYS c 217 TER 4675 LYS c 217
ATOM 4676 CB LYS D 11 -4.082 -39.843 -30. 708 1.00 35.97 C ATOM 4676 CB LYS D 11 -4.082 -39.843 -30. 708 1.00 35.97 C
ATOM 4677 CG LYS D 11 -5.127 -38.819 -31. 122 1.00 39.33 CATOM 4677 CG LYS D 11 -5.127 -38.819 -31. 122 1.00 39.33 C
ATOM 4678 CD LYS D 11 - 4.679 - 37. 401 -30. 759 1.00 42.37 CATOM 4678 CD LYS D 11-4.679-37. 401 -30. 759 1.00 42.37 C
ATOM 4679 CE LYS D 11 - 5.860 -36. 470 -30. 541 1 · 00 44.05 CATOM 4679 CE LYS D 11-5.860 -36. 470 -30. 541 1 00 44.05 C
ATOM 4680 NZ LYS D 11 -5.418 -35. 089 -30. 188 1.00 46.44 NATOM 4680 NZ LYS D 11 -5.418 -35. 089 -30. 188 1.00 46.44 N
ATOM 4681 C LYS D 11 -3.718 -40. 578 -33. 068 1.00 32.06 CATOM 4681 C LYS D 11 -3.718 -40. 578 -33. 068 1.00 32.06 C
ATOM 4682 0 LYS D 11 - 2.694 -39. 959 -33. 357 1.00 33.57 0ATOM 4682 0 LYS D 11-2.694 -39. 959 -33. 357 1.00 33.57 0
ATOM 4683 N LYS D 11 -2.954 -42. 010 -31. 123 1.00 32.44 NATOM 4683 N LYS D 11 -2.954 -42. 010 -31. 123 1.00 32.44 N
ATOM 4684 CA LYS D 11 -3.990 -41. 054 -31. 633 1.00 33.95 CATOM 4684 CA LYS D 11 -3.990 -41. 054 -31. 633 1.00 33.95 C
ATOM 4685 N ILE D 12 -4.663 - 40. 861 -33. 951 1.00 29.28 NATOM 4685 N ILE D 12 -4.663-40. 861 -33. 951 1.00 29.28 N
ATOM 4686 CA ILE D 12 -4.494一 40. 665 -35. 380 1.00 27.74 CATOM 4686 CA ILE D 12 -4.494 1 40. 665 -35. 380 1.00 27.74 C
ATOM 4687 CB ILE D 12 -4.822 -41. 968 -36. 141 1.00 27.88 CATOM 4687 CB ILE D 12 -4.822 -41. 968 -36. 141 1.00 27.88 C
ATOM 4688 CG2 ILE D 12 -4.578 -41. 781 -37. 626 1.00 29.09 CATOM 4688 CG2 ILE D 12 -4.578 -41. 781 -37. 626 1.00 29.09 C
ATOM 4689 CG1 ILE D 12 -4.007 -43. 137 -35. 562 1.00 31.39 CATOM 4689 CG1 ILE D 12 -4.007 -43. 137 -35. 562 1.00 31.39 C
ATOM 4690 CD1 ILE D 12 -2.491 -42. 974一 35. 648 1.00 28.40 CATOM 4690 CD1 ILE D 12 -2.491 -42. 974 1 35. 648 1.00 28.40 C
ATOM 4691 C ILE D 12 一 5.454 -39. 573一 35. 854 1.00 27.20 C ATOM 4692 0 ILE D 12 -6.665 - 39.762 - 35.830 1.00 23.10 0ATOM 4691 C ILE D 12 1 5.454 -39. 573 1 35. 854 1.00 27.20 C ATOM 4692 0 ILE D 12 -6.665-39.762-35.830 1.00 23.10 0
ATOM 4693 N VAL D 13 -4.904 -38.445 -36. 301 1.00 27.74 NATOM 4693 N VAL D 13 -4.904 -38.445 -36. 301 1.00 27.74 N
ATOM 4694 CA VAL D 13 -5.699 -37.253 -36. 617 1.00 27.59 CATOM 4694 CA VAL D 13 -5.699 -37.253 -36. 617 1.00 27.59 C
ATOM 4695 CB VAL D. 13 -5.206 -36.019 -35.. 821 1.00 26.16 CATOM 4695 CB VAL D. 13 -5.206 -36.019 -35 .. 821 1.00 26.16 C
ATOM 4696 CG1 VAL D 13 - 6.026 -34.801 -36. 197 1.00 28.30 CATOM 4696 CG1 VAL D 13-6.026 -34.801 -36. 197 1.00 28.30 C
ATOM 4697 CG2 VAL D 13 -5.296 - 36.277 -34. 332 1.00 26.57 CATOM 4697 CG2 VAL D 13 -5.296-36.277 -34. 332 1.00 26.57 C
ATOM 4698 C VAL D 13 -5.667 -36.885 -38. 100 1.0027.62 CATOM 4698 C VAL D 13 -5.667 -36.885 -38. 100 1.0027.62 C
ATOM 4699 0 VAL D 13 -4.631 -36.507 -38. 631 1.00 28.79 0ATOM 4699 0 VAL D 13 -4.631 -36.507 -38. 631 1.00 28.79 0
ATOM 4700 N GLU D 14 -6.808 -36.982 -38. 767 1.00 29.49 NATOM 4700 N GLU D 14 -6.808 -36.982 -38. 767 1.00 29.49 N
ATOM 4701 CA GLU D 14 -6.921 -36.454 -40. 116 1.00 31.15 CATOM 4701 CA GLU D 14 -6.921 -36.454 -40. 116 1.00 31.15 C
ATOM 4702 CB GLU D 14 -7.898n -37.294 -40. 942 1.00 30.78 CATOM 4702 CB GLU D 14 -7.898n -37.294 -40. 942 1.00 30.78 C
ATOM 4703 ,CG GLU D 14 -8.113 -36.757 -42. 346 1.0033.02 CATOM 4703, CG GLU D 14 -8.113 -36.757 -42. 346 1.0033.02 C
ATOM 4704 CD GLU D 14 -9.039 -37.628 -43. 169 1.00 35.04 CATOM 4704 CD GLU D 14 -9.039 -37.628 -43. 169 1.00 35.04 C
ATOM 4705 0E1 GLU D 14 -10.048 -38.118 -42. 617 1.0037.88 0ATOM 4705 0E1 GLU D 14 -10.048 -38.118 -42. 617 1.0037.88 0
ATOM 4706 0E2 GLU D 14 - 8.756 -37.826一 44. 367 1.0033.83 0ATOM 4706 0E2 GLU D 14-8.756 -37.826 1 44. 367 1.0033.83 0
ATOM 4707 C GLU D 14 -7.411 - 35.009 -40. 045 1.00 32.33 CATOM 4707 C GLU D 14 -7.411-35.009 -40. 045 1.00 32.33 C
ATOM 4708 0 GLU D 14 -8.585 -34.747 -39. 772 1.0033.36 0ATOM 4708 0 GLU D 14 -8.585 -34.747 -39. 772 1.0033.36 0
ATOM 4709 N VAL D 15 -6.505 - 34.073 -40. 286 1.00 32.98 NATOM 4709 N VAL D 15 -6.505-34.073 -40. 286 1.00 32.98 N
ATOM 4710 CA VAL D 15 -6.822 - 32.662 -40. 130 1.00 32.23 CATOM 4710 CA VAL D 15 -6.822-32.662 -40. 130 1.00 32.23 C
ATOM 4711 CB VAL D 15 -5.546 -31.818 -40. 167 1.0032.96 CATOM 4711 CB VAL D 15 -5.546 -31.818 -40. 167 1.0032.96 C
ATOM 4712 CG1 VAL D 15 - 5.890 -30.340 -40. 097 1.00 32.88 CATOM 4712 CG1 VAL D 15-5.890 -30.340 -40. 097 1.00 32.88 C
ATOM 4713 CG2 VAL D 15 -4.648 -32.212 -38. 999 1.0033.01 CATOM 4713 CG2 VAL D 15 -4.648 -32.212 -38. 999 1.0033.01 C
ATOM 4714 C VAL D 15 -7.764 -32.221 -41： 236 1.0031.60 CATOM 4714 C VAL D 15 -7.764 -32.221 -41: 236 1.0031.60 C
ATOM 4715 0 VAL D 15 -7.493 -32.448 -42. 413 1.00 34.69 0ATOM 4715 0 VAL D 15 -7.493 -32.448 -42. 413 1.00 34.69 0
ATOM 4716 N LYS D 16 - 8.876 -31.599 -40. 861 1.0028.49 NATOM 4716 N LYS D 16-8.876 -31.599 -40. 861 1.0028.49 N
ATOM 4717 CA LYS D 16 -9.949 -31.387 -41. 817 1.00 27.79 CATOM 4717 CA LYS D 16 -9.949 -31.387 -41.817 1.00 27.79 C
ATOM 4718 CB LYS D 16 - 32, 127 -41. 349 1.0029.53 CATOM 4718 CB LYS D 16-32, 127 -41. 349 1.0029.53 C
ATOM 4719 C6 LYS D 16 -11.122 - 33.634 -41. 578 1.0032.92 CATOM 4719 C6 LYS D 16 -11.122-33.634 -41. 578 1.0032.92 C
ATOM 4720 CD LYS D 16 -12.016 -34.403 -40. 633 1.0034.56 CATOM 4720 CD LYS D 16 -12.016 -34.403 -40. 633 1.0034.56 C
ATOM 4721 CE LYS D 16 -12.234 -35.821 -41. 134 1.0035.68 CATOM 4721 CE LYS D 16 -12.234 -35.821 -41. 134 1.0035.68 C
ATOM 4722 NZ LYS D 16 -13.535 -36.383 -40. 652 1.0038.29 NATOM 4722 NZ LYS D 16 -13.535 -36.383 -40. 652 1.0038.29 N
ATOM 4723 C LYS D 16 -10.260 -29.920 -42. 082 1.00 25.86 CATOM 4723 C LYS D 16 -10.260 -29.920 -42. 082 1.00 25.86 C
ATOM 4724 0 LYS D 16 -11.220 -29.596 - 42. 789 1.0026.76 0ATOM 4724 0 LYS D 16 -11.220 -29.596-42. 789 1.0026.76 0
ATOM 4725 N HIS D 17 -9.438 - 29.041 -41. 520 1.00 23.05 NATOM 4725 N HIS D 17 -9.438-29.041 -41. 520 1.00 23.05 N
ATOM 4726 CA HIS D 17 -9.567 -27.602 -41. 738 1.00 22.44 CATOM 4726 CA HIS D 17 -9.567 -27.602 -41. 738 1.00 22.44 C
ATOM 4727 CB HIS D 17 —8.370 -26.872一 41. 107 1.0020.27 C 5 ATOM 4727 CB HIS D 17 --8.370 -26.872 One 41. 107 1.0020.27 C Five
ATOM ,4728 CG HIS D 17 -8.502 -25. 380 -41. 103 1. 00 20.24 ATOM, 4728 CG HIS D 17 -8.502 -25. 380 -41. 103 1.00 20.24
ATOM 4729 CD2 HIS D 17 - 8.679 -24. 504 -40. 084 1. 00 19.26  ATOM 4729 CD2 HIS D 17-8.679 -24. 504 -40. 084 1. 00 19.26
ATOM 4730 ND1 HIS D 17 -8.468 -24. 626 -42. 258 1. 00 17.66  ATOM 4730 ND1 HIS D 17 -8.468 -24. 626 -42. 258 1. 00 17.66
ATOM 4731 CE1 HIS D 17 - 8.623 -23. 350 -41. 949 1. 00 20.48  ATOM 4731 CE1 HIS D 17-8.623 -23. 350 -41. 949 1. 00 20.48
ATOM 4732 NE2 HIS D 17 - 8.755 - 23. 249 -40. 637 1. 00 20.23  ATOM 4732 NE2 HIS D 17-8.755-23. 249 -40. 637 1. 00 20.23
ATOM 4733 C HIS D 17 -9.629 -27. 310 -43. 232 1. 00 21.46  ATOM 4733 C HIS D 17 -9.629 -27. 310 -43. 232 1. 00 21.46
ATOM 4734 0 HIS D 17 -8.863 -27. 863 -44. 014 1. 00 25.13  ATOM 4734 0 HIS D 17 -8.863 -27. 863 -44. 014 1. 00 25.13
ATOM 4735 N PRO D 18 -10.546 -26. 429 -43. 649 1. 00 23.35  ATOM 4735 N PRO D 18 -10.546 -26. 429 -43. 649 1. 00 23.35
ATOM 4736 CD PRO D 18 - I11.472 -25. 670 -42. 796 1. 00 21.13  ATOM 4736 CD PRO D 18-I11.472 -25. 670 -42. 796 1. 00 21.13
ATOM 4737 CA PRO D 18 - 10.75 o4 -26. 149 -45. 074 1. 00 22.28  ATOM 4737 CA PRO D 18-10.75 o4 -26. 149 -45. 074 1. 00 22.28
ATOM 4738 GB PRO D 18 -25. 144 -45. 084 1. 00 21.91  ATOM 4738 GB PRO D 18 -25. 144 -45. 084 1.00 21.91
ATOM 4739 CG PRO D. 18 -11.959 -24. 600 -43. 711 1. 0ひ 21.69  ATOM 4739 CG PRO D. 18 -11.959 -24. 600 -43. 711 1. 0 21.69
ATOM 4740 C PRO D 18 -9.536 -25. 651 -45. 846 1. 00 23.38  ATOM 4740 C PRO D 18 -9.536 -25. 651 -45. 846 1. 00 23.38
ATOM 4741 0 PRO D 18 - 9.403 -25. 936 - 47. 037 1. 00 25.54  ATOM 4741 0 PRO D 18-9.403 -25. 936-47. 037 1. 00 25.54
ATOM 4742 N LEU D 19 -8.642 -24. 924 -45. 185 1. 00 23.95  ATOM 4742 N LEU D 19 -8.642 -24. 924 -45. 185 1. 00 23.95
ATOM 4743 CA LEU D 19 -7.401 -24. 506 -45. 842 1. 00 23.43  ATOM 4743 CA LEU D 19 -7.401 -24. 506 -45. 842 1. 00 23.43
ATOM 4744 CB LEU D 19 - 6.669 -23. 442 -45. 007 1. 00 24.09  ATOM 4744 CB LEU D 19-6.669 -23. 442 -45. 007 1. 00 24.09
ATOM 4745 CG LEU D 19 -7.376 -22. 078 -44. 895 1. 00 22.59  ATOM 4745 CG LEU D 19 -7.376 -22. 078 -44. 895 1. 00 22.59
ATOM 4746 CD1 LEU D 19 -6.519 -21. 102 —44. 100 1. 00 21.12  ATOM 4746 CD1 LEU D 19 -6.519 -21. 102 —44. 100 1. 00 21.12
ATOM 4747 CD2 LEU D 19 -7.645 -21. 530 -46. 283 1. 00 21.62  ATOM 4747 CD2 LEU D 19 -7.645 -21. 530 -46. 283 1. 00 21.62
ATOM 4748 C LEU D 19 - 6.471 -25. 690 - 46. 109 1. ,00 23.81  ATOM 4748 C LEU D 19-6.471 -25. 690-46. 109 1., 00 23.81
ATOM 4749 0 LEU D 19 - 5.870 - 25. 776 -47. 177 1. ,00 23.92  ATOM 4749 0 LEU D 19-5.870-25. 776 -47. 177 1., 00 23.92
ATOM 4750 N VAL D 20 -6.355 -26. 609 -45. 154 1. ,00 22.80  ATOM 4750 N VAL D 20 -6.355 -26. 609 -45. 154 1., 00 22.80
ATOM 4751 CA VAL D 20 -5.566 - 27. 810 -45. 398 1. ,00 21.42  ATOM 4751 CA VAL D 20 -5.566-27. 810 -45. 398 1., 00 21.42
ATOM 4752 CB VAL D 20 - 5.497 -28. 712 -44. 139 1. ,00 20.10  ATOM 4752 CB VAL D 20-5.497 -28. 712 -44. 139 1., 00 20.10
ATOM 4753 CG1 VAL D 20 -4.778 - 30. 002 - 44. 458 1, .00 18.15  ATOM 4753 CG1 VAL D 20 -4.778-30. 002-44. 458 1, .00 18.15
ATOM 4754 C62 VAL D 20 -4.743 -28. 004 -43. 036 1, .00 16.08  ATOM 4754 C62 VAL D 20 -4.743 -28. 004 -43. 036 1, .00 16.08
ATOM 4755 C VAL D 20 -6.158 -28. 588 - 46. 578 1. .00 22.61  ATOM 4755 C VAL D 20 -6.158 -28. 588-46. 578 1. .00 22.61
ATOM 4756 0 VAL D 20 - 5.432 -29. 009 -47. 472 1. .00 22.86  ATOM 4756 0 VAL D 20-5.432 -29. 009 -47. 472 1. .00 22.86
ATOM 4757 N LYS D 21 -7.477 -28. 746 -46. 605 1, .00 24.43  ATOM 4757 N LYS D 21 -7.477 -28. 746 -46. 605 1, .00 24.43
ATOM 4758 CA LYS D 21 - 8.122 -29. 427 - 47. 725 1, .00 26.19  ATOM 4758 CA LYS D 21-8.122 -29. 427-47. 725 1, .00 26.19
ATOM 4759 CB LYS D 21 - 9.631 -29. 510 -47. 518 1, .00 29.26  ATOM 4759 CB LYS D 21-9.631 -29. 510 -47. 518 1, .00 29.26
ATOM 4760 CG LYS D 21 -10.100 - 30. 408 -46. 389 1 .00 32.26  ATOM 4760 CG LYS D 21 -10.100-30. 408 -46. 389 1 .00 32.26
ATOM 4761 CD LYS D 21 -11.620 -30. 512 -46. 434 1 .00 32.27  ATOM 4761 CD LYS D 21 -11.620 -30. 512 -46. 434 1 .00 32.27
ATOM 4762 CE LYS D 21 -12.183 -31. 194 -45. 207 1 .00 34.20  ATOM 4762 CE LYS D 21 -12.183 -31. 194 -45. 207 1 .00 34.20
ATOM 4763 NZ LYS D 21 —13.668 -31. 043一 45. 142 1 .00 35.71 ATOM 4764 C LYS D 21 -7.856 -28.718 -49.052 1.00 26.76 CATOM 4763 NZ LYS D 21 —13.668 -31. 043 1 45. 142 1 .00 35.71 ATOM 4764 C LYS D 21 -7.856 -28.718 -49.052 1.00 26.76 C
ATOM 4765 0 LYS D 21 -7.542 -29.361 -50. 056 1. 00 25. 73 0ATOM 4765 0 LYS D 21 -7.542 -29.361 -50. 056 1. 00 25. 73 0
ATOM 4766 N HIS D 22 - 7.993 -27.394一 49. 059 1. 00 25. 36 NATOM 4766 N HIS D 22-7.993 -27.394 One 49. 059 1. 00 25. 36 N
ATOM 4767 GA HIS D 22 -7.760 -26.612 -50. 273 1. 00 24. 11 CATOM 4767 GA HIS D 22 -7.760 -26.612 -50. 273 1. 00 24. 11 C
ATOM 4768 CB HIS D 22 -8.065 -25.129 -50. 003 1. 00 24. 53 CATOM 4768 CB HIS D 22 -8.065 -25.129 -50. 003 1. 00 24. 53 C
ATOM 4769 CG HIS D 22 -7.697 -24.215 -51. 132 1. 00 23. 89 CATOM 4769 CG HIS D 22 -7.697 -24.215 -51. 132 1. 00 23. 89 C
ATOM 4770 CD2 HIS D 22 -6.677 -23.334 -51■ 270 1. 00 24.27 CATOM 4770 CD2 HIS D 22 -6.677 -23.334 -51 270 1.00 24.27 C
ATOM 4771 ND1 HIS D 22 -8.434 - 24.133 - 52. 295 1. 00 22.94 NATOM 4771 ND1 HIS D 22 -8.434-24.133-52. 295 1. 00 22.94 N
ATOM 4772 CE1 HIS D 22 -7.885 -23.239 -53. 099 1. 00 23. 49 CATOM 4772 CE1 HIS D 22 -7.885 -23.239 -53. 099 1. 00 23. 49 C
ATOM 4773 NE2 HIS D 22 -6.817 -22.740 - 52. 502 1. 00 25. 66 NATOM 4773 NE2 HIS D 22 -6.817 -22.740-52. 502 1. 00 25. 66 N
ATOM 4774 C HIS D 22 - 6.319 - 26.769一 50. 773- 1. 00 24. 93 CATOM 4774 C HIS D 22-6.319-26.769 1 50. 773-1. 00 24. 93 C
ATOM 4775 .0 HIS D 22 -6.089 -27.050 -51. 947 1. 00 24.85 . 0ATOM 4775 .0 HIS D 22 -6.089 -27.050 -51. 947 1. 00 24.85. 0
ATOM 4776 N LYS D 23 -5.352 -26.600 -49. 877 1. 00 25. 22 NATOM 4776 N LYS D 23 -5.352 -26.600 -49. 877 1. 00 25. 22 N
ATOM 4777 CA LYS D 23 - 3.954 -26.647 -50. 262 1. 00 25. 90 CATOM 4777 CA LYS D 23-3.954 -26.647 -50. 262 1. 00 25. 90 C
ATOM 4778 CB LYS D 23 - 3.074 -26.164 - 49. 107 1. 00 26.70 CATOM 4778 CB LYS D 23-3.074 -26.164-49. 107 1. 00 26.70 C
ATOM 4779 CG LYS D 23 -3.034 -24.640 -48. 965 1. 00 28. 68 CATOM 4779 CG LYS D 23 -3.034 -24.640 -48. 965 1. 00 28. 68 C
ATOM 4780 CD LYS D 23 -2.637 -24.192 -47. 562 1. 00 26.85 CATOM 4780 CD LYS D 23 -2.637 -24.192 -47. 562 1. 00 26.85 C
ATOM 4781 CE LYS D 23 -3.123 - 22.772 -47. 266 1. 00 25.88 CATOM 4781 CE LYS D 23 -3.123-22.772 -47. 266 1. 00 25.88 C
ATOM 4782 NZ LYS D 23 -2.417 - 21.727 -48. 068 1. 00 23. 94 NATOM 4782 NZ LYS D 23 -2.417-21.727 -48. 068 1. 00 23. 94 N
ATOM 4783 C LYS D 23 -3.541 -28.052 -50. 698 1. ,00 28.32 CATOM 4783 C LYS D 23 -3.541 -28.052 -50. 698 1., 00 28.32 C
ATOM 4784 0 LYS D 23 -2.864 -28.207 -51. 714 1. ,00 27. 50 0ATOM 4784 0 LYS D 23 -2.864 -28.207 -51. 714 1., 00 27. 50 0
ATOM 4785 N LEU D 24 - 3.961 - 29.072 -49. 947 1. .00 28.29 NATOM 4785 N LEU D 24-3.961-29.072 -49. 947 1. .00 28.29 N
ATOM 4786 CA LEU D 24 -3.659 - 30.457 -50. 316 1. .00 28.99 CATOM 4786 CA LEU D 24 -3.659-30.457 -50. 316 1. .00 28.99 C
ATOM 4787 CB LEU D 24 -4.211 -31.439 -49. 265 1. .00 29. 23 CATOM 4787 CB LEU D 24 -4.211 -31.439 -49. 265 1. .00 29. 23 C
ATOM 4788 CG LEU D 24 - 4.158 -32.944 -49. 598 1, .00 30.05 CATOM 4788 CG LEU D 24-4.158 -32.944 -49. 598 1, .00 30.05 C
ATOM 4789 CD1 LEU D 24 - 4.378 -33.777 - 48. 337 1, .00 30.15 CATOM 4789 CD1 LEU D 24-4.378 -33.777-48. 337 1, .00 30.15 C
ATOM 4790 CD2 LEU D 24 - 5, 233 -33.286 -50. 613 1, .00 28.18 CATOM 4790 CD2 LEU D 24-5, 233 -33.286 -50. 613 1, .00 28.18 C
ATOM 4791 C LEU D 24 -4.262 -30.770 -51. 684 1, .00 28. 88 CATOM 4791 C LEU D 24 -4.262 -30.770 -51. 684 1, .00 28. 88 C
ATOM 4792 0 LEU D 24 - 3.645 -31.453 -52. 499 1 .00 29.41 0ATOM 4792 0 LEU D 24-3.645 -31.453 -52. 499 1 .00 29.41 0
ATO 4793 N GLY D 25 -5.460 -30.255 -51. 934 1 .00 27.58 NATO 4793 N GLY D 25 -5.460 -30.255 -51. 934 1 .00 27.58 N
ATOM 4794 CA GLY D 25 -6.118 -30.513 -53. 200 1 ■ 00. 29.32 CATOM 4794 CA GLY D 25 -6.118 -30.513 -53. 200 1 ■ 00. 29.32 C
ATOM 4795 C GLY D 25 -5.331 -30.018 -54. 400 1 .00 29. 69 CATOM 4795 C GLY D 25 -5.331 -30.018 -54. 400 1 .00 29. 69 C
ATOM 4796 0 GLY D 25 -5.243 - 30.699 -55. 418 1 .00 31.36 0ATOM 4796 0 GLY D 25 -5.243-30.699 -55. 418 1 .00 31.36 0
ATOM 4797 N LEU D 26 -4.756 - 28.826 -54. 289 1 .00 28. 67 NATOM 4797 N LEU D 26 -4.756-28.826 -54. 289 1 .00 28. 67 N
ATOM 4798 CA LEU D 26 -3.964 -28.271 -55. 374 1 .00 26. 89 CATOM 4798 CA LEU D 26 -3.964 -28.271 -55. 374 1 .00 26. 89 C
ATOM 4799 CB LEU D 26 -3.515 - 26.844 - 55. 015 1 .00 27.22 C ATOM 4800 CG LEU D 26 - 4.652 - 25.808 - 55.056 1.00 27.90 CATOM 4799 CB LEU D 26 -3.515-26.844-55. 015 1 .00 27.22 C ATOM 4800 CG LEU D 26-4.652-25.808-55.056 1.00 27.90 C
ATOM 4801 CD1 LEU D 26 -A.234 -24.513 -54.393 1. 00 25.34 CATOM 4801 CD1 LEU D 26 -A.234 -24.513 -54.393 1.00 25.34 C
ATOM 4802 GD2 LEU D 26 -5.049 -25.571 - 56.502 1. 00 26.97 CATOM 4802 GD2 LEU D 26 -5.049 -25.571-56.502 1.00 26.97 C
ATOM 4803 C LEU D 26 -2.758 - 29.161 -55.663 1. 00 27.36 CATOM 4803 C LEU D 26 -2.758-29.161 -55.663 1. 00 27.36 C
ATOM 4804 0 LEU D 26 -2.321 -29.269 -56.810 1. 00 27.58 0ATOM 4804 0 LEU D 26 -2.321 -29.269 -56.810 1.00 27.58 0
ATOM 4805 N MET D 27 -2.232 -29.814 -54.626 1. 00 26.11 NATOM 4805 N MET D 27 -2.232 -29.814 -54.626 1.00 26.11 N
ATOM 4806 CA MET D 27 -1.062 -30.671 - 54.792 1. 00 26.84 CATOM 4806 CA MET D 27 -1.062 -30.671-54.792 1. 00 26.84 C
ATOM 4807 CB MET D 27 -0.489 -31. 069 -53.425 1. 00 28.13 CATOM 4807 CB MET D 27 -0.489 -31. 069 -53.425 1. 00 28.13 C
ATOM 4808 CG MET D 27 0.036 -29.907 -52.583 1. 00 24.50 CATOM 4808 CG MET D 27 0.036 -29.907 -52.583 1.00 24.50 C
ATOM 4809 SD MET D 27 0.786 - 30.446 - 51.023 1. 00 24.75 SATOM 4809 SD MET D 27 0.786-30.446-51.023 1. 00 24.75 S
ATOM 4810 CE MET D 27 2.475 - 30.896 -51.587 1. 00 19.54 CATOM 4810 CE MET D 27 2.475-30.896 -51.587 1. 00 19.54 C
ATOM 4811 C MET D 27 -1.366 -31. 928 -55.606 1. 00 27.95 CATOM 4811 C MET D 27 -1.366 -31. 928 -55.606 1. 00 27.95 C
ATOM 4812 0 MET D 27 -0.466 -32.537 -56.180 1. 00 28.72 0ATOM 4812 0 MET D 27 -0.466 -32.537 -56.180 1.00 28.72 0
ATOM 4813 N ARG D 28 -2.631 -32. 324 -55.671 1. 00 29.31 NATOM 4813 N ARG D 28 -2.631 -32. 324 -55.671 1. 00 29.31 N
ATOM 4814 CA AR6 D 28 - 2.965 - 33.554 -56.372 1. 00 30.49 CATOM 4814 CA AR6 D 28-2.965-33.554 -56.372 1. 00 30.49 C
ATOM 4815 CB ARG D 28 -4.319 -34.085 -55.889 1. ,00 29.95 CATOM 4815 CB ARG D 28 -4.319 -34.085 -55.889 1., 00 29.95 C
ATOM 4816 CG ARG D 28 -4.352 -34.480 -54.410 1. 00 29.89 CATOM 4816 CG ARG D 28 -4.352 -34.480 -54.410 1. 00 29.89 C
ATOM 4817 CD ARG D 28 -5.589 -35.306 -54.107 1. .00 29.57 CATOM 4817 CD ARG D 28 -5.589 -35.306 -54.107 1..00 29.57 C
ATOM 4818 NE ARG D 28 - 5.796 -35.531 -52.675 1. ,00 31.52 NATOM 4818 NE ARG D 28-5.796 -35.531 -52.675 1., 00 31.52 N
ATOM 4819 CZ ARG D 28 -5.369 - 36.604 -52.009 1. .00 30.48 CATOM 4819 CZ ARG D 28 -5.369-36.604 -52.009 1. .00 30.48 C
ATOM 4820 NH1 ARG D 28 - 4.700 -37.558 -52.640 1. ,00 30.49 NATOM 4820 NH1 ARG D 28-4.700 -37.558 -52.640 1., 00 30.49 N
ATOM 4821 NH2 ARG D 28 -5.633 -36.735 -50.715 1. .00 28.78 NATOM 4821 NH2 ARG D 28 -5.633 -36.735 -50.715 1. .00 28.78 N
ATOM 4822 C ARG D 28 -2.985 - 33.358 - 57.889 1, .00 33.00 CATOM 4822 C ARG D 28 -2.985-33.358-57.889 1, .00 33.00 C
ATOM 4823 0 ARG D 28 -3.059 -34.327 -58.643 1. .00 31.38 0ATOM 4823 0 ARG D 28 -3.059 -34.327 -58.643 1. .00 31.38 0
ATOM 4824 N GLU D 29 - 2.919 -32.105 -58.332 1, .00 36.30 NATOM 4824 N GLU D 29-2.919 -32.105 -58.332 1, .00 36.30 N
ATOM 4825 CA GLU D 29 - 2.981 -31. 785一 59.759 1 .00 42.81 CATOM 4825 CA GLU D 29-2.981 -31. 785 1 59.759 1 .00 42.81 C
ATOM 4826 CB GLU D 29 - 3.172 -30. 282 - 59.947 1, .00 46.69 CATOM 4826 CB GLU D 29-3.172 -30. 282-59.947 1, .00 46.69 C
ATOM 4827 CG GLU D 29 -2.918 - 29. 793 -61.368 1 .00 53.21 CATOM 4827 CG GLU D 29 -2.918-29. 793 -61.368 1 .00 53.21 C
ATOM 4828 CD GLU D 29 -2.763 - 28. 278 -61.439 1 • 00 57.48 CATOM 4828 CD GLU D 29 -2.763-28. 278 -61.439 1 • 00 57.48 C
ATOM 4829 0E1 GLU D 29 -1.721 -27. 806 -61.953 1 .00 57.49 0ATOM 4829 0E1 GLU D 29 -1.721 -27. 806 -61.953 1 .00 57.49 0
ATOM 4830 0E2 GLU D 29 -3.683 -27. 560 -60.974 1 ■ 00 59.41 0ATOM 4830 0E2 GLU D 29 -3.683 -27. 560 -60.974 1 ∎ 00 59.41 0
ATOM 4831 C GLU D 29 -1.722 -32. 225 - 60.502 1 .00 43.60 CATOM 4831 C GLU D 29 -1.722 -32. 225-60.502 1 .00 43.60 C
ATOM 4832 0 GLU D 29 -0.629 - 31. 759 -60.201 1 ■ 00 44.29 0ATOM 4832 0 GLU D 29 -0.629-31. 759 -60.201 1 ■ 00 44.29 0
ATOM 4833 N 6LN D 30 -1 · 881 - 33. 105 -61.485 1 .00 46.51 NATOM 4833 N 6LN D 30 -1 881-33. 105 -61.485 1 .00 46.51 N
ATOM 4834 CA GLN D 30 -0.739 - 33. 740 -62.147 1 .00 49.40 CATOM 4834 CA GLN D 30 -0.739-33. 740 -62.147 1 .00 49.40 C
ATOM 4835 CB GLN D 30 -1.224一 34. 703 -63.236 1 .00 51.80 C ATOM 4836 C6 6LN D 30 -1.891 -34.018 -64.435 1.00 54.95 CATOM 4835 CB GLN D 30 -1.224 1 34. 703 -63.236 1 .00 51.80 C ATOM 4836 C6 6LN D 30 -1.891 -34.018 -64.435 1.00 54.95 C
ATOM 4837 CD 6LN D 30 -1.947 34.911 -65.673 1.0057.46 CATOM 4837 CD 6LN D 30 -1.947 34.911 -65.673 1.0057.46 C
ATOM 4838 0E1 6LN D 30 -1.234 - 35.917 -65.764 1.00 57.65 0ATOM 4838 0E1 6LN D 30 -1.234-35.917 -65.764 1.00 57.65 0
ATOM 4839 NE2 GLN D 30 -2.797 -34.544 -66.634 1.00 56.79 NATOM 4839 NE2 GLN D 30 -2.797 -34.544 -66.634 1.00 56.79 N
ATOM 4840 C GLN D 30 0.227 -32.732 - 62.770 1.00 50.34 CATOM 4840 C GLN D 30 0.227 -32.732-62.770 1.00 50.34 C
ATOM 4841 0 GLN D 30 1.446 -32.872 -62.661 1.00 50.04 0ATOM 4841 0 GLN D 30 1.446 -32.872 -62.661 1.00 50.04 0
ATOM 4842 N ASP D 31 -0.324 -31.716 -63.424 1.00 50.59 NATOM 4842 N ASP D 31 -0.324 -31.716 -63.424 1.00 50.59 N
ATOM 4843 CA ASP D 31 0.478 -30.783 -64.205 1.00 51.69 CATOM 4843 CA ASP D 31 0.478 -30.783 -64.205 1.00 51.69 C
ATOM 4844 CB ASP D 31 - 0.339 -30.275 -65.392 1.00 54.57 CATOM 4844 CB ASP D 31-0.339 -30.275 -65.392 1.00 54.57 C
ATOM 4845 CG ASP D 31 - 1.720 -29.800 -64.982 1.00 58.40 CATOM 4845 CG ASP D 31-1.720 -29.800 -64.982 1.00 58.40 C
ATOM 4846 0D1 ASP D 31 -2.033 -28.611 -65.204 1.00 60.78 0ATOM 4846 0D1 ASP D 31 -2.033 -28.611 -65.204 1.00 60.78 0
ATOM 4847 .0D2 ASP D 31 -2.493 -30.619 -64.433 1.00 60.25 0ATOM 4847 .0D2 ASP D 31 -2.493 -30.619 -64.433 1.00 60.25 0
ATOM 4848 C ASP D 31 0.961 -29.598 -63.369 1.00 49： 93 CATOM 4848 C ASP D 31 0.961 -29.598 -63.369 1.00 49: 93 C
ATOM 4849 0 ASP D 31 1.060 -28.476 -63.869 1.0051.00 0ATOM 4849 0 ASP D 31 1.060 -28.476 -63.869 1.0051.00 0
ATOM 4850 N ILE D 32 1.258 -29.851 -62.098 1.0045.77 NATOM 4850 N ILE D 32 1.258 -29.851 -62.098 1.0045.77 N
ATOM 4851 CA ILE D 32 1.693 -28.792 -61.194 1.00 41.53 CATOM 4851 CA ILE D 32 1.693 -28.792 -61.194 1.00 41.53 C
ATOM 4852 CB ILE D 32 1.271 —29.091 -59.731 1.00 39.96 CATOM 4852 CB ILE D 32 1.271 -29.091 -59.731 1.00 39.96 C
ATOM 4853 CG2 ILE D 32 1.941 - 30.363 -59.243 1.00 36.91 CATOM 4853 CG2 ILE D 32 1.941-30.363 -59.243 1.00 36.91 C
ATOM 4854 CG1 ILE D 32 1.659 -27.925 -58.826 1.00 38.71 CATOM 4854 CG1 ILE D 32 1.659 -27.925 -58.826 1.00 38.71 C
ATOM 4855 CD1 ILE D 32 1.153 -28.061 -57.401 1.00 39.57 CATOM 4855 CD1 ILE D 32 1.153 -28.061 -57.401 1.00 39.57 C
ATOM 4856 C ILE D 32 3.209 -28.632 -61.256 1.00 39.11 CATOM 4856 C ILE D 32 3.209 -28.632 -61.256 1.00 39.11 C
ATOM 4857 0 ILE D 32 3.936 -29.611 -61.429 1.00 38.36 0ATOM 4857 0 ILE D 32 3.936 -29.611 -61.429 1.00 38.36 0
ATOM 4858 N SER D 33 3.674 -27.393 -61'.110 1.00 36.16 NATOM 4858 N SER D 33 3.674 -27.393 -61'.110 1.00 36.16 N
ATOM 4859 CA SER D 33 5.093 -27.074 -61 · 240 1.00 34.67 CATOM 4859 CA SER D 33 5.093 -27.074 -61240 1.00 34.67 C
ATOM 4860 CB SER D 33 5.276 - 25.590 -61.532 1.00 32.34 CATOM 4860 CB SER D 33 5.276-25.590 -61.532 1.00 32.34 C
ATOM 4861 06 SER D 33 5.122 - 24.837 -60.338 1.00 35.14 0ATOM 4861 06 SER D 33 5.122-24.837 -60.338 1.00 35.14 0
ATOM 4862 C SER D 33 5.827 -27.410 -59.949 1.00 34.48 CATOM 4862 C SER D 33 5.827 -27.410 -59.949 1.00 34.48 C
ATOM 4863 0 SER D 33 5.212 -27.520 -58.893 1.00 37.08 0ATOM 4863 0 SER D 33 5.212 -27.520 -58.893 1.00 37.08 0
ATOM 4864 N THR D 34 7.145 -27.539 -60.022 1.00 31.93 NATOM 4864 N THR D 34 7.145 -27.539 -60.022 1.00 31.93 N
ATO 4865 CA THR D 34 7.898 -27.936 -58.852 1.00 32.29 CATO 4865 CA THR D 34 7.898 -27.936 -58.852 1.00 32.29 C
ATOM 4866 CB THR D 34 9.366 -28.287 -59.219 1.00 32.58 CATOM 4866 CB THR D 34 9.366 -28.287 -59.219 1.00 32.58 C
ATOM 4867 061 THR D 34 10.004 -28.916 - 58.102 1.00 33.51 0ATOM 4867 061 THR D 34 10.004 -28.916-58.102 1.00 33.51 0
ATOM 4868 CG2 THR D 34 10.144 -27.039 -59.565 1.0036.37 CATOM 4868 CG2 THR D 34 10.144 -27.039 -59.565 1.0036.37 C
ATOM 4869 C THR D 34 7.871 - 26.830 -57.798 1.00 31.61 CATOM 4869 C THR D 34 7.871-26.830 -57.798 1.00 31.61 C
ATOM 4870 0 THR D 34 7.892 -27.101 -56.604 1.00 32.30 0ATOM 4870 0 THR D 34 7.892 -27.101 -56.604 1.00 32.30 0
ATOM 4871 N LYS D 35 7.811 -25.579 -58.233 1.00 32.25 N ATOM 4872 CA LYS D 35 7.798 -24.467 -57.294 1.00 31.07ATOM 4871 N LYS D 35 7.811 -25.579 -58.233 1.00 32.25 N ATOM 4872 CA LYS D 35 7.798 -24.467 -57.294 1.00 31.07
ATOM 4873 CB LYS D 35 7.897 - 23.133 -58.038 1. 00 33.69ATOM 4873 CB LYS D 35 7.897-23.133 -58.038 1. 00 33.69
ATOM 4874 CG LYS D 35 7.864 -21.921 -57.122 1. 00 35.31ATOM 4874 CG LYS D 35 7.864 -21.921 -57.122 1. 00 35.31
ATOM 4875 CD LYS D 35 6.916 -20.848 -57.650 1. 00 39.87ATOM 4875 CD LYS D 35 6.916 -20.848 -57.650 1. 00 39.87
ATOM 4876 CE LYS D 35 7.072 -19.526 -56.884 1. 00 42.44ATOM 4876 CE LYS D 35 7.072 -19.526 -56.884 1. 00 42.44
ATOM 4877 NZ LYS D 35 6.815 -19.641 - 55.407 1. 00 41.77ATOM 4877 NZ LYS D 35 6.815 -19.641-55.407 1.00 41.77
ATOM 4878 C LYS D 35 6.526 -24.483 -56.453 1. 00 30.26ATOM 4878 C LYS D 35 6.526 -24.483 -56.453 1. 00 30.26
ATOM 4879 0 LYS D 35 6.584 -24.384 - 55.224 1. 00 28.68ATOM 4879 0 LYS D 35 6.584 -24.384-55.224 1. 00 28.68
ATOM 4880 N ARG D 36 5.382 -24.620 -57.118 1. 00 28.47ATOM 4880 N ARG D 36 5.382 -24.620 -57.118 1.00 28.47
ATOM 4881 CA ARG D 36 4.088 -24.572 - 56.439 1. 00 27.63ATOM 4881 CA ARG D 36 4.088 -24.572-56.439 1. 00 27.63
ATOM 4882 CB AR6 D 36 2.958 - 24, 547 -57.471 1. 00 30.47ATOM 4882 CB AR6 D 36 2.958-24, 547 -57.471 1. 00 30.47
ATOM 4883 CG ARG D 36 1.572 -24.401 -56.869 1. 00 34.55ATOM 4883 CG ARG D 36 1.572 -24.401 -56.869 1.00 34.55
ATOM 4884 CD ARG D 36 1.372 -23.011 -56.289 1. 00 39.00ATOM 4884 CD ARG D 36 1.372 -23.011 -56.289 1.00 39.00
ATOM 4885 NE ARG D 36 1.307 -21.983 -57.326 1. 00 43.43ATOM 4885 NE ARG D 36 1.307 -21.983 -57.326 1. 00 43.43
ATOM 4886 CZ ARG D 36 1.652 -20.711 -57.137 1. 00 44.82ATOM 4886 CZ ARG D 36 1.652 -20.711 -57.137 1. 00 44.82
ATOM 4887 NH1 ARG D 36 2.090 - 20.315 -55.953 1. 00 47.10ATOM 4887 NH1 ARG D 36 2.090-20.315 -55.953 1.00 47.10
ATOM 4888 NH2 ARG D 36 1.553 -19.832 -58.125 1. 00 47.08ATOM 4888 NH2 ARG D 36 1.553 -19.832 -58.125 1.00 47.08
ATOM 4889 C ARG D 36 3.895 -25.762 - 55.495 1. 00 26.55ATOM 4889 C ARG D 36 3.895 -25.762-55.495 1. 00 26.55
ATOM 4890 0 ARG D 36 3.371 -25.615 -54.380 1. ,00 22.24ATOM 4890 0 ARG D 36 3.371 -25.615 -54.380 1., 00 22.24
ATOM 4891 N PHE D 37 4.326 -26.937 - 55.947 1. .00 26.03ATOM 4891 N PHE D 37 4.326 -26.937-55.947 1. .00 26.03
ATOM 4892 CA PHE D 37 4.253 - 28.146 -55.133 1. ,00 26.35ATOM 4892 CA PHE D 37 4.253-28.146 -55.133 1., 00 26.35
ATOM 4893 CB PHE D 37 4.745 -29.357 -55.934 1. .00 24.56ATOM 4893 CB PHE D 37 4.745 -29.357 -55.934 1. .00 24.56
ATOM 4894 CG PHE D 37 4.461 -30.680 -55.273 1. .00 25.15ATOM 4894 CG PHE D 37 4.461 -30.680 -55.273 1. .00 25.15
ATOM 4895 CD1 PHE D 37 3.346 -31.424 -55.632 1, .00 27.12ATOM 4895 CD1 PHE D 37 3.346 -31.424 -55.632 1, .00 27.12
ATOM 4896 CD2 PHE D 37 5.307 -31.176 -54.293 1, .00 27.22ATOM 4896 CD2 PHE D 37 5.307 -31.176 -54.293 1, .00 27.22
ATOM 4897 CE1 PHE D 37 3.079 -32.645 -55.023 1, .00 30.07ATOM 4897 CE1 PHE D 37 3.079 -32.645 -55.023 1, .00 30.07
ATOM 4898 CE2 PHE D 37 5.054 - 32.394 - 53.676 1, .00 28.31ATOM 4898 CE2 PHE D 37 5.054-32.394-53.676 1, .00 28.31
ATOM 4899 CZ PHE D 37 3.935 -33.131 -54.043 1 • 00 30.71ATOM 4899 CZ PHE D 37 3.935 -33.131 -54.043 1 • 00 30.71
ATOM 4900 C PHE D 37 5.113 -27.972 -53.890 1 • 00 26.48ATOM 4900 C PHE D 37 5.113 -27.972 -53.890 1 • 00 26.48
ATOM 4901 0 PHE D 37 4.730 - 28.376 -52.796 1 • 00 28.97ATOM 4901 0 PHE D 37 4.730-28.376 -52.796 1 • 00 28.97
ATOM 4902 N ARG D 38 6.271 -27.349 -54.073 1 ■ 00 27.98ATOM 4902 N ARG D 38 6.271 -27.349 -54.073 1 ■ 00 27.98
ATOM 4903 CA ARG D 38 7.273 -27.207 -53.023 1 .00 29.73ATOM 4903 CA ARG D 38 7.273 -27.207 -53.023 1 .00 29.73
ATOM 4904 CB ARG D 38 8.562 -26.645 -53.626 1 .00 31.17ATOM 4904 CB ARG D 38 8.562 -26.645 -53.626 1 .00 31.17
ATOM 4905 CG ARG D 38 9.783 -26.725 -52.731 1 .00 37.07ATOM 4905 CG ARG D 38 9.783 -26.725 -52.731 1 .00 37.07
ATOM 4906 CD ARG D 38 11.022 - 26.174 - 53.451 1 .00 38.67ATOM 4906 CD ARG D 38 11.022-26.174-53.451 1 .00 38.67
ATOM 4907 NE ARG D 38 11.042 -26.516 -54.874 1 .00 39.74 ATOM 4908 CZ ARG D 38 12.132 - 26.474 - 55.636 1.00 40.99 CATOM 4907 NE ARG D 38 11.042 -26.516 -54.874 1 .00 39.74 ATOM 4908 CZ ARG D 38 12.132-26.474-55.636 1.00 40.99 C
ATOM 4909 NH1 ARG D 38 13.291 - 26.108 - 55. 110 1. 00 44.85 NATOM 4909 NH1 ARG D 38 13.291-26.108-55. 110 1. 00 44.85 N
ATOM 4910 NH2 ARG D 38 12.068 -26.784 -56. 923 1. 00 41.53 NATOM 4910 NH2 ARG D 38 12.068 -26.784 -56. 923 1. 00 41.53 N
ATOM 4911 C ARG D 38 6.793 -26.303 -51. 892 1. 00 30.48 CATOM 4911 C ARG D 38 6.793 -26.303 -51. 892 1. 00 30.48 C
ATOM 4912 0 ARG D 38 7.091 -26.545 -50. 724 1. 00 31.80 0ATOM 4912 0 ARG D 38 7.091 -26.545 -50. 724 1. 00 31.80 0
ATOM 4913 N 6LU D 39 6.051 -25.258 - 52. 229 1. 00 30.72 NATOM 4913 N 6LU D 39 6.051 -25.258-52. 229 1. 00 30.72 N
ATOM 4914 CA GLU D 39 5.571 -24.352 - 51. 196 1. 00 32.78 CATOM 4914 CA GLU D 39 5.571 -24.352-51. 196 1. 00 32.78 C
ATOM 4915 CB 6LU D 39 5.391 -22.932 -51. 755 1. 00 36.73 CATOM 4915 CB 6LU D 39 5.391 -22.932 -51. 755 1. 00 36.73 C
ATOM 4916 C6 GLU D 39 4.503 -22.824 - 52. 974 1. 00 41.25 CATOM 4916 C6 GLU D 39 4.503 -22.824-52. 974 1.00 41.25 C
ATOM 4917 CD GLU D 39 4.179 -21.381 -53. 317 1. 00 45.62 CATOM 4917 CD GLU D 39 4.179 -21.381 -53. 317 1. 00 45.62 C
ATOM 4918 0E1 GLU D 39 4.041 -20.564 -52. 380 1. 00 49.26 0ATOM 4918 0E1 GLU D 39 4.041 -20.564 -52. 380 1. 00 49.26 0
ATOM 4919 ΌΕ2 GLU D 39 4.065 -21.063 -54. 521 1. 00 47.23 0ATOM 4919 ΌΕ2 GLU D 39 4.065 -21.063 -54. 521 1.00 47.23 0
ATOM 4920 C GLU D 39 4.277 - 24.831 - 50. 548 1. 00 29.98 CATOM 4920 C GLU D 39 4.277-24.831-50. 548 1. 00 29.98 C
ATOM 4921 0 GLU D 39 4.079 -24.636 -49. 354 1. 00 30.09 0ATOM 4921 0 GLU D 39 4.079 -24.636 -49. 354 1. 00 30.09 0
ATOM 4922 N LEU D 40 3.403 - 25.460 -51. 331 1. 00 27.71 NATOM 4922 N LEU D 40 3.403-25.460 -51. 331 1. 00 27.71 N
ATOM 4923 CA LEU D 40 2.222 -26.117 - 50. 770 1. 00 25.73 CATOM 4923 CA LEU D 40 2.222 -26.117-50. 770 1.00 25.73 C
ATOM 4924 CB LEU D 40 1.376 -26.721 - 51. 885 1. 00 23.55 CATOM 4924 CB LEU D 40 1.376 -26.721-51. 885 1. 00 23.55 C
ATOM 4925 GG LEU D 40 0.593 -25.681 -52. 683 1. 00 25.96 CATOM 4925 GG LEU D 40 0.593 -25.681 -52. 683 1. 00 25.96 C
ATOM 4926 CD1 LEU D 40 -0.081 -26.326 -53. 875 1. 00 25.16 CATOM 4926 CD1 LEU D 40 -0.081 -26.326 -53. 875 1. 00 25.16 C
ATOM 4927 CD2 LEU D 40 -0.442 - 25.031 - 51. 758 1. 00 26.50 CATOM 4927 CD2 LEU D 40 -0.442-25.031-51. 758 1. 00 26.50 C
ATOM 4928 C LEU D 40 2.602 -27.204 - 49. 763 1. 00 24.60 CATOM 4928 C LEU D 40 2.602 -27.204-49. 763 1. 00 24.60 C
ATOM 4929 0 LEU D 40 1.970 -27.334 - 48. 725 1. 00 24.03 0ATOM 4929 0 LEU D 40 1.970 -27.334-48. 725 1.00 24.03 0
ATOM 4930 N ALA D 41 3.650 -27.967 -50.067 1. 00 24.21 NATOM 4930 N ALA D 41 3.650 -27.967 -50.067 1.00 24.21 N
ATOM 4931 CA ALA D 41 4.130 - 28.986 -49. 149 1. ,00 24.46 CATOM 4931 CA ALA D 41 4.130-28.986 -49. 149 1., 00 24.46 C
ATOM 4932 CB ALA D 41 5.296 - 29.757 -49. 772 1. ,00 27.12 CATOM 4932 CB ALA D 41 5.296-29.757 -49. 772 1., 00 27.12 C
ATOM 4933 C ALA D 41 4.565 - 28.340 - 47. 846 1. .00 24.28 CATOM 4933 C ALA D 41 4.565-28.340-47. 846 1. .00 24.28 C
ATOM 4934 0 ALA D 41 4.390 -28.910 -46. 774 1. .00 26.32 0ATOM 4934 0 ALA D 41 4.390 -28.910 -46.774 1..00 26.32 0
ATOM 4935 N SER D 42 5.126 -27.141 - 47. 935 1. .00 23.64 NATOM 4935 N SER D 42 5.126 -27.141-47. 935 1. .00 23.64 N
ATOM 4936 CA SER D 42 5.551 -26.439 -46. 740 1. .00 22.19 CATOM 4936 CA SER D 42 5.551 -26.439 -46. 740 1. .00 22.19 C
ATO 4937 CB SER D 42 6.599 -25.389 -47. 096 1, .00 23.58 GATO 4937 CB SER D 42 6.599 -25.389 -47. 096 1, .00 23.58 G
ATOM 4938 OG SER D 42 7.435 - 25.139 -45. 981 1. .00 28.84 0ATOM 4938 OG SER D 42 7.435-25.139 -45. 981 1. .00 28.84 0
ATOM 4939 C SER D 42 4.373 -25.775 -46. 018 1. .00 21.79 CATOM 4939 C SER D 42 4.373 -25.775 -46. 018 1. .00 21.79 C
ATOM 4940 0 SER D 42 4.315 -25.751 -44. 790 1, .00 20.02 0ATOM 4940 0 SER D 42 4.315 -25.751 -44. 790 1, .00 20.02 0
ATOM 4941 N GLU D 43 3.433 -25.228 -46. 771 1, .00 21.16 NATOM 4941 N GLU D 43 3.433 -25.228 -46. 771 1, .00 21.16 N
ATOM 4942 CA GLU D 43 2.286 -24.593 -46. 133 1, .00 23.54 GATOM 4942 CA GLU D 43 2.286 -24.593 -46. 133 1, .00 23.54 G
ATOM 4943 CB GLU D 43 1.390 -23.924 -47. 178 1. .00 23.43 C ATOM 4944 CG 6LU D 43 - 22.563 -47.610 1.00 23.62ATOM 4943 CB GLU D 43 1.390 -23.924 -47. 178 1. .00 23.43 C ATOM 4944 CG 6LU D 43-22.563 -47.610 1.00 23.62
ATOM 4945 CD GLU D 43 1.409 -22.166 -48. 976 •1. 00 24.21ATOM 4945 CD GLU D 43 1.409 -22.166 -48. 976 • 1.00 24.21
ATOM 4946 0E1 GLU D 43 0.268 -22.523 -49. 325 1. 00 24.51ATOM 4946 0E1 GLU D 43 0.268 -22.523 -49. 325 1. 00 24.51
ATOM 4947 0E2 GLU D 43 2.169 -21.492 -49. 703 1. 00 28.25ATOM 4947 0E2 GLU D 43 2.169 -21.492 -49. 703 1. 00 28.25
ATOM 4948 C GLU D 43 1.484 -25.602 - 45. 319 1. 00 23.81ATOM 4948 C GLU D 43 1.484 -25.602-45. 319 1. 00 23.81
ATOM 4949 0 GLU D 43 1.215 -25.380 -44. 135 1. 00 24.30ATOM 4949 0 GLU D 43 1.215 -25.380 -44. 135 1. 00 24.30
ATOM 4950 N VAL D 44 1.121 -26.717 -45. 943 1. 00 24.31ATOM 4950 N VAL D 44 1.121 -26.717 -45. 943 1. 00 24.31
ATOM 4951 CA VAL D 44 0.348 -27.735 - 45. 248 1. 00 25.12ATOM 4951 CA VAL D 44 0.348 -27.735-45. 248 1. 00 25.12
ATOM 4952 GB VAL D 44 -0.062 -28.869 -46. 206 1. 00 26.37ATOM 4952 GB VAL D 44 -0.062 -28.869 -46. 206 1. 00 26.37
ATOM 4953 CG1 VAL D 44 1.170 - 29.433 -46. 874 1. 00 34.50ATOM 4953 CG1 VAL D 44 1.170-29.433 -46. 874 1. 00 34.50
ATOM 4954 CG2 VAL D 44 -0.798 -29.965 -45. 446 1. 00 25.26ATOM 4954 CG2 VAL D 44 -0.798 -29.965 -45. 446 1. 00 25.26
ATOM 4955 C VAL D 44 1.145 - 28.298 -44. 072 1. 00 23.87ATOM 4955 C VAL D 44 1.145-28.298 -44. 072 1. 00 23.87
ATOM 4956 0 VAL D 44 0.597 -28.521 - 42. 998 1. 00 26.25ATOM 4956 0 VAL D 44 0.597 -28.521-42. 998 1. 00 26.25
ATOM 4957 N GLY D 45 2.444 -28.499 -44. 255 1. 00 22.55ATOM 4957 N GLY D 45 2.444 -28.499 -44. 255 1. 00 22.55
ATOM 4958 CA GLY D 45 3.261 - 28.921 - 43. 130 1. 00 21.41ATOM 4958 CA GLY D 45 3.261-28.921-43. 130 1. 00 21.41
ATOM 4959 C GLY D 45 3.153 -27.947 -41. 960 1. 00 22.26ATOM 4959 C GLY D 45 3.153 -27.947 -41. 960 1. 00 22.26
ATOM 4960 0 GLY D 45 3.091 -28.347 -40. 797 1. ,00 20.27ATOM 4960 0 GLY D 45 3.091 -28.347 -40. 797 1., 00 20.27
ATOM 4961 N SER D 46 3.127 - 26.656 - 42. 271 1. 00 20.30ATOM 4961 N SER D 46 3.127-26.656-42. 271 1. 00 20.30
ATOM 4962 CA SER D 46 2.960 - 25.629 - 41. 253 1. ,00 18.61ATOM 4962 CA SER D 46 2.960-25.629-41. 253 1., 00 18.61
ATOM 4963 CB SER D 46 2.986 -24.235 -41. 890 1. ,00 18.56ATOM 4963 CB SER D 46 2.986 -24.235 -41. 890 1., 00 18.56
ATOM 4964 OG SER D 46 3.029 -23.248 -40. 883 1. ,00 17.72ATOM 4964 OG SER D 46 3.029 -23.248 -40. 883 1., 00 17.72
ATOM 4965 C SER D 46 1.641 -25.802 -40. 505 1. .00 18.23ATOM 4965 C SER D 46 1.641 -25.802 -40. 505 1. .00 18.23
ATOM 4966 0 SER D 46 1.609 -25.778 -39. 276 1. ,00 17.68ATOM 4966 0 SER D 46 1.609 -25.778 -39. 276 1., 00 17.68
ATOM 4967 N LEU D 47 0.554 -25.986 - 41. 248 1. ,00 17.00ATOM 4967 N LEU D 47 0.554 -25.986-41. 248 1., 00 17.00
ATOM 4968 CA LEU D 47 -0.755 -26.171 -40. 630 1. .00 18.85ATOM 4968 CA LEU D 47 -0.755 -26.171 -40. 630 1. .00 18.85
ATOM 4969 GB LEU D 47 -1.837 -26.207 -41. 712 1. .00 17.78ATOM 4969 GB LEU D 47 -1.837 -26.207 -41. 712 1. .00 17.78
ATOM 4970 CG LEU D 47 -1.759 -24.996 -42. 657 1, .00 20.10ATOM 4970 CG LEU D 47 -1.759 -24.996 -42.657 1, .00 20.10
ATOM 4971 CD1 LEU D 47 - 2.937 -25.000 - 43. 638 1. .00 17.01ATOM 4971 CD1 LEU D 47-2.937 -25.000-43. 638 1. .00 17.01
ATOM 4972 CD2 LEU D 47 -1.730 -23.709 -41. 826 1. .00 15.85ATOM 4972 CD2 LEU D 47 -1.730 -23.709 -41. 826 1. .00 15.85
ATO 4973 C LEU D 47 -0.816 -27.436 -39. 763 1, .00 19.72ATO 4973 C LEU D 47 -0.816 -27.436 -39. 763 1, .00 19.72
ATOM 4974 0 LEU D 47 - 1.434 -27.438 -38. 696 1, .00 19.38ATOM 4974 0 LEU D 47-1.434 -27.438 -38. 696 1, .00 19.38
ATOM 4975 N LEU D 48 -0.153 -28.502 -40. 211 1 .00 21.50ATOM 4975 N LEU D 48 -0.153 -28.502 -40. 211 1 .00 21.50
ATOM 4976 CA LEU D 48 - 0.095 - 29.742 -39. 447 1, .00 21.44ATOM 4976 CA LEU D 48-0.095-29.742 -39. 447 1, .00 21.44
ATOM 4977 CB LEU D 48 0.567 -30.837 -40. 284 1, .00 21.06ATOM 4977 CB LEU D 48 0.567 -30.837 -40. 284 1, .00 21.06
ATOM 4978 CG LEU D 48 -0.223 -41. 546 1 ■ 00 25.44ATOM 4978 CG LEU D 48 -0.223 -41. 546 1 ■ 00 25.44
ATOM 4979 CD1 LEU D 48 0.595 -32.149 -42. 400 1 • 00 25.20 ATOM 4980 CD2 LEU D 48 -1.579 -31.811 - 41.163 1.00 23.61 CATOM 4979 CD1 LEU D 48 0.595 -32.149 -42. 400 1 • 00 25.20 ATOM 4980 CD2 LEU D 48 -1.579 -31.811-41.163 1.00 23.61 C
ATOM 4981 C LEU D 48 0.667 -29.544 -38.136 1. 00 22.30 CATOM 4981 C LEU D 48 0.667 -29.544 -38.136 1. 00 22.30 C
ATOM 4982 0 LEU D 48 0.303 -30.108 -37.105 1. 00 22.33 0ATOM 4982 0 LEU D 48 0.303 -30.108 -37.105 1.00 22.33 0
ATOM 4983 N THR D 49 1.716 -28.727 - 38.176 1. 00 23.56 NATOM 4983 N THR D 49 1.716 -28.727-38.176 1. 00 23.56 N
ATOM 4984 CA THR D 49 2.511 -28. 34 -36.991 1. 00 23.27 CATOM 4984 CA THR D 49 2.511 -28. 34 -36.991 1. 00 23.27 C
ATOM 4985 CB THR D 49 3.691 -27.516 -37. 359 1. 00 25.20 CATOM 4985 CB THR D 49 3.691 -27.516 -37. 359 1. 00 25.20 C
ATOM 4986 0G1 THR D 49 4.523 -28.180 -38. 321 1. 00 27.09 0ATOM 4986 0G1 THR D 49 4.523 -28.180 -38. 321 1. 00 27.09 0
ATOM 4987 CG2 THR D 49 4.516 -27.172 -36. 136 1. 00 23.40 GATOM 4987 CG2 THR D 49 4.516 -27.172 -36. 136 1. 00 23.40 G
ATOM 4988 C THR D 49 1.650 -27.769 -35. 914 1. 00 25.42 CATOM 4988 C THR D 49 1.650 -27.769 -35. 914 1.00 25.42 C
ATOM 4989 0 THR D 49 1.805 -28.035 -34. 720 1. 00 25.37 0ATOM 4989 0 THR D 49 1.805 -28.035 -34. 720 1.00 25.37 0
ATOM 4990 N TY D 50 0.722 - 26.922 -36. 347 1. 00 25.83 NATOM 4990 N TY D 50 0.722-26.922 -36. 347 1. 00 25.83 N
ATOM 4991 CA TYR D 50 -0.153 -26.204 - 35. 435 1. 00 26.92 CATOM 4991 CA TYR D 50 -0.153 -26.204-35. 435 1. 00 26.92 C
ATOM 4992 CB TYR D 50 -0.984 -25.184 -36. 214 1. 00 27.94 CATOM 4992 CB TYR D 50 -0.984 -25.184 -36. 214 1. 00 27.94 C
ATOM 4993 CG TYR D 50 -1.857 - 24· 293 -35. 361 1. 00 27.21 CATOM 4993 CG TYR D 50 -1.857-24 293 -35. 361 1. 00 27.21 C
ATOM 4994 CD1 TYR D 50 -1.311 -23.239 -34. 644 1. 00 28.80 GATOM 4994 CD1 TYR D 50 -1.311 -23.239 -34. 644 1. 00 28.80 G
ATOM 4995 CE1 TYR D 50 -2.112 - 22.382 -33. 913 1. 00 29.57 GATOM 4995 CE1 TYR D 50 -2.112-22.382 -33. 913 1. 00 29.57 G
ATOM 4996 CD2 TYR D 50 - 3.235 -24.472 - 35. 318 1. .00 30.87 CATOM 4996 CD2 TYR D 50-3.235 -24.472-35. 318 1. .00 30.87 C
ATOM 4997 CE2 TYR D 50 - 4.048 -23.619 - 34. 584 1. ,00 29.93 CATOM 4997 CE2 TYR D 50-4.048 -23.619-34. 584 1., 00 29.93 C
ATOM 4998 CZ TYR D 50 -3.478 - 22.576 - 33. 884 1. ,00 29.93 CATOM 4998 CZ TYR D 50 -3.478-22.576-33. 884 1., 00 29.93 C
ATOM 4999 OH TYR D 50 -4.270 -21.731 -33. 1 0 1. .00 30.41 0ATOM 4999 OH TYR D 50 -4.270 -21.731 -33. 1 0 1. .00 30.41 0
ATOM 5000 C TYR D 50 - 1.081 -27.184 - 34. 732 1. .00 27.35 CATOM 5000 C TYR D 50-1.081 -27.184-34. 732 1. .00 27.35 C
ATOM 5001 0 TYR D 50 - 1.248 -27.145 -33. 514 1. .00 24.79 0ATOM 5001 0 TYR D 50-1.248 -27.145 -33. 514 1. .00 24.79 0
ATOM 5002 N GLU D 51 - 1.693 -28.053 - 35'.524 1. .00 27.76 NATOM 5002 N GLU D 51-1.693 -28.053-35'.524 1. .00 27.76 N
ATOM 5003 CA GLU D 51 -2.551 -29.094 -34. 998 1, .00 29.07 CATOM 5003 CA GLU D 51 -2.551 -29.094 -34. 998 1, .00 29.07 C
ATOM 5004 CB GLU D 51 -3.089 -29.941 - 36. 154 1, .00 29.59 CATOM 5004 CB GLU D 51 -3.089 -29.941-36. 154 1, .00 29.59 C
ATOM 5005 Cfi GLU D 51 - 3.963 - 29.160 -37. 118 1, .00 34.32 CATOM 5005 Cfi GLU D 51-3.963-29.160 -37. 118 1, .00 34.32 C
ATOM 5006 CD GLU D 51 -5.291 - 28.768 -36. 491 1, .00 35.17 CATOM 5006 CD GLU D 51 -5.291-28.768 -36. 491 1, .00 35.17 C
ATOM 5007 0E1 GLU D 51 -5.680 -29.421 -35. 499 1, .00 34.54 0ATOM 5007 0E1 GLU D 51 -5.680 -29.421 -35. 499 1, .00 34.54 0
ATOM 5008 0E2 GLU D 51 -5.942 -27.814 -36. 988 1, .00 34.18 0ATOM 5008 0E2 GLU D 51 -5.942 -27.814 -36. 988 1, .00 34.18 0
ATOM 5009 C GLU D 51 -1.785 - 29.973 -34. 013 .1 .00 28.07 CATOM 5009 C GLU D 51 -1.785-29.973 -34. 013 .1 .00 28.07 C
ATOM 5010 0 GLU D 51 -2.297 -30.317 - 32. 951 1 .00 28.02 0ATOM 5010 0 GLU D 51 -2.297 -30.317-32. 951 1 .00 28.02 0
ATOM 5011 N ALA D 52 -0.550 -30.318 - 34. 362 1 .00 27.26 NATOM 5011 N ALA D 52 -0.550 -30.318-34. 362 1 .00 27.26 N
ATOM 5012 CA ALA D 52 0.204 -31.302 -33. 596 1 .00 26.84 CATOM 5012 CA ALA D 52 0.204 -31.302 -33. 596 1 .00 26.84 C
ATOM 5013 CB ALA D 52 1.269 -31.937 - 34. 477 1 .00 25.50 CATOM 5013 CB ALA D 52 1.269 -31.937-34. 477 1 .00 25.50 C
ATOM 5014 C ALA D 52 0.845 -30.725 -32. 332 1 .00 26.79 CATOM 5014 C ALA D 52 0.845 -30.725 -32. 332 1 .00 26.79 C
ATOM 5015 0 ALA D 52 1.266 -31.481 一 31. 454 1 ■ 00 27.32 0 ATOM 5016 N THR D 53 0.927 -29.399 -32.236 1.00 24.62 NATOM 5015 0 ALA D 52 1.266 -31.481 One 31. 454 1 ∎ 00 27.32 0 ATOM 5016 N THR D 53 0.927 -29.399 -32.236 1.00 24.62 N
ATOM 5017 CA THR D 53 1.526 -28.768 -31.063 1. 00 26.23 CATOM 5017 CA THR D 53 1.526 -28.768 -31.063 1.00 26.23 C
ATOM 5018 CB THR D 53 2.541 - 27.675 -31.466 1. 00 26.76 CATOM 5018 CB THR D 53 2.541-27.675 -31.466 1. 00 26.76 C
ATOM 5019 0G1 THR D 53 1.905 - 26.727 -32.328 1. 00 29.63 0ATOM 5019 0G1 THR D 53 1.905-26.727 -32.328 1.00 29.63 0
ATOM 5020 CG2 THR D 53 3.728 -28.287 -32.180 1. 00 28.13 CATOM 5020 CG2 THR D 53 3.728 -28.287 -32.180 1. 00 28.13 C
ATOM 5021 C THR D 53 0.499 -28.149 -30.105 1. 00 25.56 CATOM 5021 C THR D 53 0.499 -28.149 -30.105 1. 00 25.56 C
ATOM 5022 0 THR D 53 0.865 -27.559 - 29.087 1. 00 26.49 0ATOM 5022 0 THR D 53 0.865 -27.559-29.087 1.00 26.49 0
ATOM 5023 N ALA D 54 -0.780 - 28.293 - 30.432 1. 00 24.30 NATOM 5023 N ALA D 54 -0.780-28.293-30.432 1. 00 24.30 N
ATOM 5024 CA ALA D 54 -1.861 -27.738 -29.626 1. 00 25.08 CATOM 5024 CA ALA D 54 -1.861 -27.738 -29.626 1. 00 25.08 C
ATOM 5025 CB ALA D 54 - 3.197 -28.202 -30.178 1. 00 24.10 CATOM 5025 CB ALA D 54-3.197 -28.202 -30.178 1. 00 24.10 C
ATOM 5026 C ALA D 54 - 1.746 - 28.126 -28.155 1. 00 26.24 CATOM 5026 C ALA D 54-1.746-28.126 -28.155 1.00 26.24 C
ATOM 5027 .0 ALA D 54 - 2.245 -27.427 -27.276 1. 00 25.64 0ATOM 5027 .0 ALA D 54-2.245 -27.427 -27.276 1. 00 25.64 0
ATOM 5028 N ASP D 55 -1.077 -29.240 -27.887 1. 00 28.46 .ATOM 5028 N ASP D 55 -1.077 -29.240 -27.887 1. 00 28.46.
ATOM 5029 CA ASP D 55 -1.039 - 29.795 -26.539 1. 00 32.27 CATOM 5029 CA ASP D 55 -1.039-29.795 -26.539 1. 00 32.27 C
ATOM 5030 CB ASP D 55 - 1.264 -31.304 -26.600 1. 00 37.68 CATOM 5030 CB ASP D 55-1.264 -31.304 -26.600 1.00 37.68 C
ATOM 5031 CG ASP D 55 -0.327 -31.991 -27.578 1. 00 42.08 CATOM 5031 CG ASP D 55 -0.327 -31.991 -27.578 1. 00 42.08 C
ATOM 5032 0D1 ASP D 55 0.319 - 31.280 - 28.384 1. 00 47.50 .0ATOM 5032 0D1 ASP D 55 0.319-31.280-28.384 1. 00 47.50 .0
ATOM 5033 0D2 ASP D 55 - 0.233 -33.236 -27.545 1. ,00 44.09 0ATOM 5033 0D2 ASP D 55-0.233 -33.236 -27.545 1., 00 44.09 0
ATOM 5034 C ASP D 55 0.281 -29.501 -25.834 1. ,00 32.80 CATOM 5034 C ASP D 55 0.281 -29.501 -25.834 1., 00 32.80 C
ATOM 5035 0 ASP D 55 0.428 -29.763 -24.640 1. .00 33.86 0ATOM 5035 0 ASP D 55 0.428 -29.763 -24.640 1. .00 33.86 0
ATOM 5036 N LEU D 56 1.240 - 28.956 -26.574 1. .00 31.03 NATOM 5036 N LEU D 56 1.240-28.956 -26.574 1. .00 31.03 N
ATOM 5037 CA LEU D 56 2.528 -28.598 -25.999 1. ,00 29.53 CATOM 5037 CA LEU D 56 2.528 -28.598 -25.999 1., 00 29.53 C
ATOM 5038 CB LEU D 56 3.385 -27.915 -27.058 1. .00 30.90 CATOM 5038 CB LEU D 56 3.385 -27.915 -27.058 1. .00 30.90 C
ATOM 5039 CG LEU D 56 4.821 -27.588 -26.667 1. .00 33.06 CATOM 5039 CG LEU D 56 4.821 -27.588 -26.667 1. .00 33.06 C
ATOM 5040 CD1 LEU D 56 5.598 - 28.881 -26.448 1. .00 34.20 CATOM 5040 CD1 LEU D 56 5.598-28.881 -26.448 1. .00 34.20 C
ATOM 5041 CD2 LEU D 56 5.458 -26.758 - 27.767 1, .00 34.23 CATOM 5041 CD2 LEU D 56 5.458 -26.758-27.767 1, .00 34.23 C
ATOM 5042 C LEU D 56 2.313 -27.657 -24.821 1, .00 28.86 CATOM 5042 C LEU D 56 2.313 -27.657 -24.821 1, .00 28.86 C
ATOM 5043 0 LEU D 56 1.469 -26.768 -24.886 1 .00 28.25 0ATOM 5043 0 LEU D 56 1.469 -26.768 -24.886 1 .00 28.25 0
ATOM 5044 N GLU D 57 3.072 -27.849 -23.745 1 .00 28.07 NATOM 5044 N GLU D 57 3.072 -27.849 -23.745 1 .00 28.07 N
ATOM 5045 CA GLU D 57 2.905 -27.018 -22.554 1, .00 28.10 CATOM 5045 CA GLU D 57 2.905 -27.018 -22.554 1, .00 28.10 C
ATOM 5046 CB GLU D 57 3.450 -27.722 -21.309 1 • 00 28.51 CATOM 5046 CB GLU D 57 3.450 -27.722 -21.309 1 • 00 28.51 C
ATOM 5047 CG GLU D 57 4: 957 -27.633 1 .00 30.17 CATOM 5047 CG GLU D 57 4: 957 -27.633 1 .00 30.17 C
ATOM 5048 CD GLU D 57 5.692 - 28.694 - 21.959 1 .00 29.84 CATOM 5048 CD GLU D 57 5.692-28.694-21.959 1 .00 29.84 C
ATOM 5049 0E1 GLU D 57 5.028 -29.511 -22.633 1 • 00 31.87 0ATOM 5049 0E1 GLU D 57 5.028 -29.511 -22.633 1 • 00 31.87 0
ATOM 5050 0E2 GLU D 57 6.937 -28.712 - 21.905 1 .00 29.62 0ATOM 5050 0E2 GLU D 57 6.937 -28.712-21.905 1 .00 29.62 0
ATOM 5051 C GLU D 57 3.601 -25.669 - 22.687 1 .00 28.17 C ATOM 5052 0 GLU D 57 4.579 - 25.525 - 23.424 1.00 25.99ATOM 5051 C GLU D 57 3.601 -25.669-22.687 1 .00 28.17 C ATOM 5052 0 GLU D 57 4.579-25.525-23.424 1.00 25.99
ATOM 5053 N THR D 58 3.084 - 24.683 -21■ 962 1. 00 27.43ATOM 5053 N THR D 58 3.084-24.683 -21 ■ 962 1. 00 27.43
ATOM 5054 CA THR D 58 3.782 -23.417 -21.779 1. 00 28.34ATOM 5054 CA THR D 58 3.782 -23.417 -21.779 1. 00 28.34
ATOM 5055 CB THR D 58 2.878 -22.208 -22.118 1. 00 28.86ATOM 5055 CB THR D 58 2.878 -22.208 -22.118 1. 00 28.86
ATOM 5056 0G1 THR D 58 1.694 -22.246 - 21.306 1. 00 29.60ATOM 5056 0G1 THR D 58 1.694 -22.246-21.306 1. 00 29.60
ATOM 5057 CG2 THR D 58 2.488 -22.232 -23.585 1. 00 26.18ATOM 5057 CG2 THR D 58 2.488 -22.232 -23.585 1.00 26.18
ATOM 5058 C THR D 58 4.226 -23.291 - 20.331 1. 00 28.88ATOM 5058 C THR D 58 4.226 -23.291-20.331 1. 00 28.88
ATOM 5059 0 THR D 58 3.685 -23.966 -19.446 1. 00 27.69ATOM 5059 0 THR D 58 3.685 -23.966 -19.446 1. 00 27.69
ATOM 5060 N GLU D 59 5.219 -22.437 -20.101 1. 00 28.46ATOM 5060 N GLU D 59 5.219 -22.437 -20.101 1. 00 28.46
ATOM 5061 CA GLU D 59 5.604 -22.052 -18.750 1. 00 30.96ATOM 5061 CA GLU D 59 5.604 -22.052 -18.750 1. 00 30.96
ATOM 5062 CB GLU D 59 7.010 -22.569 -18.434 1. 00 32.55ATOM 5062 CB GLU D 59 7.010 -22.569 -18.434 1. 00 32.55
ATOM 5063 C6 GLU D 59 7.082 -24.083 -18, 360 1. 00 37.26ATOM 5063 C6 GLU D 59 7.082 -24.083 -18, 360 1. 00 37.26
ATOM 5064 CD GLU D 59 8.448 -24.589 -17.948 1. 00 39.52ATOM 5064 CD GLU D 59 8.448 -24.589 -17.948 1. 00 39.52
ATOM 5065 0E1 GLU D 59 9.451 -23.903 -18.241 1. 00 42.91ATOM 5065 0E1 GLU D 59 9.451 -23.903 -18.241 1. 00 42.91
ATOM 5066 0E2 GLU D 59 8.512 -25.674 - 17.328 1. 00 40.94ATOM 5066 0E2 GLU D 59 8.512 -25.674-17.328 1. 00 40.94
ATOM 5067 C GLU D 59 5.549 - 20.535 -18.556 1. 00 30.88ATOM 5067 C GLU D 59 5.549-20.535 -18.556 1. 00 30.88
ATOM 5068 0 GLU D 59 5.891 -19.765 -19.460 1. 00 29.72ATOM 5068 0 GLU D 59 5.891 -19.765 -19.460 1. 00 29.72
ATOM 5069 N LYS D 60 5.114 -20.110 -17.374 1. 00 28.81ATOM 5069 N LYS D 60 5.114 -20.110 -17.374 1. 00 28.81
ATOM 5070 CA LYS D 60 5.066 -18.693 -17.066 1. 00 30.24ATOM 5070 CA LYS D 60 5.066 -18.693 -17.066 1. 00 30.24
ATOM 5071 CB LYS D 60 4.215 -18.437 -15.821 1. 00 29.85ATOM 5071 CB LYS D 60 4.215 -18.437 -15.821 1. 00 29.85
ATOM 5072 CG LYS D 60 2.784 -18.911 -15.909 1. ,00 31.33ATOM 5072 CG LYS D 60 2.784 -18.911 -15.909 1., 00 31.33
ATOM 5073 CD LYS D 60 2.050 -18.653—14.591 1. .00 33.69ATOM 5073 CD LYS D 60 2.050 -18.653—14.591 1. .00 33.69
ATOM 5074 CE LYS D 60 0.562 -18.984 - 14'· 695 1. .00 33.30ATOM 5074 CE LYS D 60 0.562 -18.984-14 '695 1. .00 33.30
ATOM 5075 NZ LYS D 60 -0.149 —18.676 -13.433 1. .00 35.32ATOM 5075 NZ LYS D 60 -0.149 —18.676 -13.433 1. .00 35.32
ATOM 5076 C LYS D 60 6.475 -18.175 -16.822 1. .00 30.08ATOM 5076 C LYS D 60 6.475 -18.175 -16.822 1. .00 30.08
ATOM 5077 0 LYS D 60 7.220 -18.726 -16.012 1, .00 29.57ATOM 5077 0 LYS D 60 7.220 -18.726 -16.012 1, .00 29.57
ATOM 5078 N VAL D 61 6.836 -17.103 -17.513 1, .00 31.49ATOM 5078 N VAL D 61 6.836 -17.103 -17.513 1, .00 31.49
ATOM 5079 CA VAL D 61 8.129 -16.470 -17.285 1, .00 32.73ATOM 5079 CA VAL D 61 8.129 -16.470 -17.285 1, .00 32.73
ATOM 5080 CB VAL D 61 9.109 -16.773 -18.441 1 .00 32.59ATOM 5080 CB VAL D 61 9.109 -16.773 -18.441 1 .00 32.59
ATOM' 5081 CG1 VAL D 61 10.491一 16.228 -18.108 1 .00 31.51ATOM '5081 CG1 VAL D 61 10.491 1 16.228 -18.108 1 .00 31.51
ATOM 5082 CG2 VAL D 61 9.170 -18.270 -18.680 1 • 00 31.57ATOM 5082 CG2 VAL D 61 9.170 -18.270 -18.680 1 • 00 31.57
ATOM 5083 C VAL D 61 7.963 -14.963 -17.153 1 ,00 32.87ATOM 5083 C VAL D 61 7.963 -14.963 -17.153 1, 00 32.87
ATOM 5084 0 VAL D 61 7.252 -14.334—17.939 1 .00 30.51ATOM 5084 0 VAL D 61 7.252 -14.334—17.939 1 .00 30.51
ATOM 5085 N THR D 62 8.618 -14.383 -16.153 1 .00 32.88ATOM 5085 N THR D 62 8.618 -14.383 -16.153 1 .00 32.88
ATOM 5086 CA THR D 62 8.531 -12.944 -15.956 1 .00 34.11ATOM 5086 CA THR D 62 8.531 -12.944 -15.956 1 .00 34.11
ATOM 5087 CB THR D 62 8.539一 12.584 -14.458 1 .00 34.66 ATOM 5088 061 THR D 62 7.281 -12.947 -13.887 1.00 33.61 0ATOM 5087 CB THR D 62 8.539 One 12.584 -14.458 1 .00 34.66 ATOM 5088 061 THR D 62 7.281 -12.947 -13.887 1.00 33.61 0
ATOM 5089 CG2 THR D 62 8.763 -11.090 -14. 260 1. 00 36.31 CATOM 5089 CG2 THR D 62 8.763 -11.090 -14. 260 1. 00 36.31 C
ATOM 5090 C THR D 62 9.661 -12.211 -16. 658 1. 00 33.76 CATOM 5090 C THR D 62 9.661 -12.211 -16. 658 1. 00 33.76 C
ATOM 5091 0 THR D 62 10.834 -12.437 -16. 366 1. 00 34.08 0ATOM 5091 0 THR D 62 10.834 -12.437 -16. 366 1. 00 34.08 0
ATOM 5092 N ILE D 63 9.292 -11.340 -17. 595 1. 00 32.53 NATOM 5092 N ILE D 63 9.292 -11.340 -17. 595 1. 00 32.53 N
ATOM 5093 CA ILE D 63 10.262 -10.547 -18. 336 1. 00 33.96 CATOM 5093 CA ILE D 63 10.262 -10.547 -18. 336 1. 00 33.96 C
ATOM 5094 CB ILE D 63 10.204 - 10.841 -19. 853 1. 00 33.54 CATOM 5094 CB ILE D 63 10.204-10.841 -19. 853 1. 00 33.54 C
ATOM 5095 CG2 ILE D 63 10.564 -12.302 -20. 129 1. 00 31.94 CATOM 5095 CG2 ILE D 63 10.564 -12.302 -20. 129 1. 00 31.94 C
ATOM 5096 C61 ILE D 63 8.808 -10.512 -20. 384 1. 00 32.39 CATOM 5096 C61 ILE D 63 8.808 -10.512 -20. 384 1. 00 32.39 C
ATOM 5097 CD1 ILE D 63 8.744 -10.397 -21. 883 1. 00 32.18 CATOM 5097 CD1 ILE D 63 8.744 -10.397 -21. 883 1. 00 32.18 C
ATOM 5098 C ILE D 63 9.995 - 9.057 -18. 150 1. 00 35.95 CATOM 5098 C ILE D 63 9.995-9.057 -18. 150 1. 00 35.95 C
ATOM 5099 0 ILE D 63 8.870 -8.643 -17. 852 1. 00 35.61 0ATOM 5099 0 ILE D 63 8.870 -8.643 -17. 852 1. 00 35.61 0
ATOM 5100 N GLU D 64 11.034 -8.252 -18. 330 1. 00 36.84 .ATOM 5100 N GLU D 64 11.034 -8.252 -18. 330 1. 00 36.84.
ATOM 5101 CA GLU D 64 10.849 -6.820 - 18. 488 1. 00 38.36 CATOM 5101 CA GLU D 64 10.849 -6.820-18. 488 1. 00 38.36 C
ATOM 5102 CB GLU D 64 12.206 -6.111 -18. 543 1. 00 41.05 CATOM 5102 CB GLU D 64 12.206 -6.111 -18. 543 1. 00 41.05 C
ATOM 5103 CG GLU D 64 12.649 -5.529 -17. 209 1. 00 45.74 CATOM 5103 CG GLU D 64 12.649 -5.529 -17. 209 1. 00 45.74 C
ATOM 5104 CD GLU D 64 11.782 -4.356 -16. 771 1. 00 50.75 CATOM 5104 CD GLU D 64 11.782 -4.356 -16. 771 1.00 50.75 C
ATOM 5105 0E1 GLU D 64 11.568 -4.198 -15. 548 1. 00 52.61 0ATOM 5105 0E1 GLU D 64 11.568 -4.198 -15. 548 1. 00 52.61 0
ATOM 5106 0E2 GLU D 64 11.311 -3.590 -17. 648 1. ,00 50.80 0ATOM 5106 0E2 GLU D 64 11.311 -3.590 -17. 648 1., 00 50.80 0
ATOM 5107 C GLU D 64 10.073 - 6.558 -19. 772 1. ,00 37.16 CATOM 5107 C GLU D 64 10.073-6.558 -19. 772 1., 00 37.16 C
ATOM 5108 0 GLU D 64 10.558 -6.821 -20. 872 1. 00 36.74 0ATOM 5108 0 GLU D 64 10.558 -6.821 -20. 872 1. 00 36.74 0
ATOM 5109 N GLY D 65 8.858 -6.044 -19. 621 1. 00 37.62 NATOM 5109 N GLY D 65 8.858 -6.044 -19. 621 1. 00 37.62 N
ATOM 5110 CA GLY D 65 8.054 -5.683 -20.770 1. ,00 36.52 CATOM 5110 CA GLY D 65 8.054 -5.683 -20.770 1., 00 36.52 C
ATOM 5111 C GLY D 65 8.252 -4.231 -21. 152 1. ,00 36.72 CATOM 5111 C GLY D 65 8.252 -4.231 -21.152 1., 00 36.72 C
ATOM 5112 0 GLY D 65 9.134 -3.553 -20. 632 1. ,00 36.94 0ATOM 5112 0 GLY D 65 9.134 -3.553 -20. 632 1., 00 36.94 0
ATOM 5113 N TRP D 66 7.420 -3.756 -22. 068 1. .00 37.45 NATOM 5113 N TRP D 66 7.420 -3.756 -22. 068 1. .00 37.45 N
ATOM 5114 CA T P D 66 7.524 -2.398 - 22. 582 1. .00 36.81 CATOM 5114 CA T P D 66 7.524 -2.398-22. 582 1. .00 36.81 C
ATOM 5115 CB TRP D 66 6.617 - 2.244 -23. 802 1. .00 33.95 CATOM 5115 CB TRP D 66 6.617-2.244 -23. 802 1. .00 33.95 C
ATOM 5116 CG TRP D 66 5.183 -2.283 -23. 447 1. .00 32.67 CATOM 5116 CG TRP D 66 5.183 -2.283 -23. 447 1. .00 32.67 C
ATOM 5117 CD2 TRP D 66 4.362 - 1.166 - 23. 094 1, .00 33.40 CATOM 5117 CD2 TRP D 66 4.362-1.166-23. 094 1, .00 33.40 C
ATOM 5118 CE2 TRP D 66 3.072 -1.668 -22. 818 1, .00 34.41 CATOM 5118 CE2 TRP D 66 3.072 -1.668 -22. 818 1, .00 34.41 C
ATOM 5119 CE3 TRP D 66 4.590 0.210 -22. 987 1, .00 29.90 CATOM 5119 CE3 TRP D 66 4.590 0.210 -22. 987 1, .00 29.90 C
ATOM 5120 CD1 TRP D 66 4.385 -3.386 -23. 373 1 .00 32.79 CATOM 5120 CD1 TRP D 66 4.385 -3.386 -23. 373 1 .00 32.79 C
ATOM 5121 NE1 TRP D 66 3.114 -3.026 -22. 996 1 .00 33.74 NATOM 5121 NE1 TRP D 66 3.114 -3.026 -22. 996 1 .00 33.74 N
ATOM 5122 CZ2 TRP D 66 2.014 -0.843 -22. 441 1 .00 32.75 CATOM 5122 CZ2 TRP D 66 2.014 -0.843 -22. 441 1 .00 32.75 C
ATOM 5123 CZ3 TRP D 66 3.541 1.027 -22. 615 1 .00 29.85 C ATOM 5124 CH2 TRP D 66 0.498 -22.345 1.00 33.29 CATOM 5123 CZ3 TRP D 66 3.541 1.027 -22. 615 1 .00 29.85 C ATOM 5124 CH2 TRP D 66 0.498 -22.345 1.00 33.29 C
ATOM 5125 C TRP D 66 7. 122 -1 · 382 -21. 518 1. 00 37.74 CATOM 5125 C TRP D 66 7. 122 -1 382 -21. 518 1. 00 37.74 C
ATOM 5126 0 TRP D 66 7.544 -0.227 -21. 554 1. 00 37.66 0ATOM 5126 0 TRP D 66 7.544 -0.227 -21. 554 1.00 37.66 0
ATOM 5127 N ASN D 67 6.293 -1.819 -20.578 1. 00 39.82 NATOM 5127 N ASN D 67 6.293 -1.819 -20.578 1. 00 39.82 N
ATOM 5128 CA ASN D 67 5.796 -0.947 -19.516 1. 00 40.32 CATOM 5128 CA ASN D 67 5.796 -0.947 -19.516 1.00 40.32 C
ATOM 5129 CB ASN D 67 4.264 -0.873 -19.571 1. 00 40.44 CATOM 5129 CB ASN D 67 4.264 -0.873 -19.571 1.00 40.44 C
ATOM 5130 GG ASN D 67 3.690 0.128 -18. 582 1. 00 42.88 CATOM 5130 GG ASN D 67 3.690 0.128 -18. 582 1. 00 42.88 C
ATOM 5131 0D1 ASN D 67 2.571 -0.035 - 18. 086 1. 00 44.18 0ATOM 5131 0D1 ASN D 67 2.571 -0.035-18. 086 1. 00 44.18 0
ATOM 5132 ND2 ASN D 67 4.453 -18. 292 1. 00 42.02 NATOM 5132 ND2 ASN D 67 4.453 -18. 292 1. 00 42.02 N
ATOM 5133 C ASN D 67 6.241 -1 · 482 - 18. 159 1. 00 39.94 CATOM 5133 C ASN D 67 6.241 -1 482-18. 159 1. 00 39.94 C
ATOM 5134 0 ASN D 67 5.617 -1.207 -17. 137 1. 00 41.13 0ATOM 5134 0 ASN D 67 5.617 -1.207 -17. 137 1. 00 41.13 0
ATOM 5135 N GLY D 68 7. 322 -2.255 - 18. 159 1. 00 40.29 NATOM 5135 N GLY D 68 7. 322 -2.255-18. 159 1. 00 40.29 N
ATOM 5136 CA GLY D 68 7. 798 - 2.858 -16. 926 1. 00 40.56 CATOM 5136 CA GLY D 68 7. 798-2.858 -16. 926 1. 00 40.56 C
ATOM 5137 C GLY D 68 7. 675 -4.371 - 16. 906 1. 00 40.37 CATOM 5137 C GLY D 68 7. 675 -4.371-16. 906 1. 00 40.37 C
ATOM 5138 0 GLY D 68 7. 366 -4.991 -17. 927 1. 00 38.38 0ATOM 5138 0 GLY D 68 7. 366 -4.991 -17. 927 1. 00 38.38 0
ATOM 5139 N PRO D 69 7. 907 -4.996 -15. 739 1. 00 40.61 NATOM 5139 N PRO D 69 7. 907 -4.996 -15. 739 1. 00 40.61 N
ATOM 5140 CD PRO 0 69 8.179 -4.310 - 14. 467 1. 00 40.85 CATOM 5140 CD PRO 0 69 8.179 -4.310-14. 467 1. 00 40.85 C
ATOM 5141 CA PRO D 69 7. 927 -6.455 - 15. 580 1. .00 40.30 CATOM 5141 CA PRO D 69 7. 927 -6.455-15. 580 1. .00 40.30 C
ATOM 5142 CB PRO D 69 8.254 -6.654 -14. 100 1. 00 40.55 CATOM 5142 CB PRO D 69 8.254 -6.654 -14. 100 1. 00 40.55 C
ATOM 5143 CG PRO D 69 8.869 - 5.367 -13. 665 1. 00 41.13 CATOM 5143 CG PRO D 69 8.869-5.367 -13. 665 1. 00 41.13 C
ATOM 5144 C PRO D 69 6.584 -7.080 -15. 943 1. ,00 39.10 CATOM 5144 C PRO D 69 6.584 -7.080 -15. 943 1., 00 39.10 C
ATOM 5145 0 PRO D 69 5.556 -6.728 - 15. 376 1, ,00 40.66 0ATOM 5145 0 PRO D 69 5.556 -6.728-15. 376 1,, 00 40.66 0
ATOM 5146 N VAL D 70 6.590 -8.009 -16.886 1. ,00 37.33 NATOM 5146 N VAL D 70 6.590 -8.009 -16.886 1., 00 37.33 N
ATOM 5147 CA VAL D 70 5.356 - 8.681 -17.258 1. .00 35.14 CATOM 5147 CA VAL D 70 5.356-8.681 -17.258 1. .00 35.14 C
ATOM 5148 CB VAL D 70 4.827 -8.155 -18.597 1. .00 33.45 CATOM 5148 CB VAL D 70 4.827 -8.155 -18.597 1. .00 33.45 C
ATOM 5149 CG1 VAL D 70 5. 841 -8.423 -19.691 1, .00 29.60 CATOM 5149 CG1 VAL D 70 5. 841 -8.423 -19.691 1, .00 29.60 C
ATOM 5150 C62 VAL D 70 3. 501 -8.798 -18. 919 1. .00 31.53 CATOM 5150 C62 VAL D 70 3. 501 -8.798 -18. 919 1. .00 31.53 C
ATOM 5151 C VAL D 70 5. 551 -10.195 - 17. 352 1. .00 36.56 CATOM 5151 C VAL D 70 5. 551 -10.195-17. 352 1. .00 36.56 C
ATOM 5152 0 VAL D 70 6. 572 -10.680 - 17. 853 1, .00 36.03 0ATOM 5152 0 VAL D 70 6. 572 -10.680-17. 853 1, .00 36.03 0
ATOM' 5153 N GLU D 71 4. 563 -10.933 -16. 857 1, .00 35.99 NATOM '5153 N GLU D 71 4. 563 -10.933 -16. 857 1, .00 35.99 N
ATOM 5154 CA GLU D 71 4. 615 -12.382 -16. 857 1, .00 35.23 CATOM 5154 CA GLU D 71 4. 615 -12.382 -16. 857 1, .00 35.23 C
ATOM 5155 CB GLU D 71 3. 922 -12.923 -15. ,610 1 • 00 36.25 CATOM 5155 CB GLU D 71 3. 922 -12.923 -15., 610 1 • 00 36.25 C
ATOM 5156 CG GLU D 71 3. 500 -14.373 - 15. 723 1 .00 36.91 CATOM 5156 CG GLU D 71 3. 500 -14.373-15. 723 1 .00 36.91 C
ATOM 5157 CD GLU D 71 3. 384 -15.054 -14. 380 1 ■ 00 35.48 CATOM 5157 CD GLU D 71 3. 384 -15.054 -14. 380 1 ■ 00 35.48 C
ATOM 5158 0E1 GLU D 71 2. 273 -15.495 -14. .024 1 .00 35.12 0ATOM 5158 0E1 GLU D 71 2. 273 -15.495 -14. .024 1 .00 35.12 0
ATOM 5159 0E2 GLU D 71 4. 416 -15.148 —13. .685 1 .00 37.52 0 ATOM 5160 C GLU D 71 3.951 -12.947 -18.108 1.0034.66ATOM 5159 0E2 GLU D 71 4. 416 -15.148 —13..685 1 .00 37.52 0 ATOM 5160 C GLU D 71 3.951 -12.947 -18.108 1.0034.66
ATOM 5161 0 GLU D 71 2.758一 12. 750 -18. 326 1. 00 34.52ATOM 5161 0 GLU D 71 2.758 1 12. 750 -18. 326 1. 00 34.52
ATOM 5162 N ILE D 72 4.734 -13. 655 -18. 918 1. 00 31.99ATOM 5162 N ILE D 72 4.734 -13. 655 -18. 918 1. 00 31.99
ATOM 5163 CA ILE D . 72 4.240 -14. 233 -20. 160 1. 00 29.25ATOM 5163 CA ILE D. 72 4.240 -14. 233 -20. 160 1. 00 29.25
ATOM 5164 CB ILE D 72 5.020 -13. 685 -21. 363 1. 00 28.20ATOM 5164 CB ILE D 72 5.020 -13. 685 -21. 363 1. 00 28.20
ATOM 5165 CG2 ILE D 72 4.882 -12. 170 -21. 411 1. 00 27.39ATOM 5165 CG2 ILE D 72 4.882 -12. 170 -21. 411 1. 00 27.39
ATOM 5166 CG1 ILE D 72 6.501 -14. 058 -21. 245 1. 00 28.82ATOM 5166 CG1 ILE D 72 6.501 -14. 058 -21. 245 1. 00 28.82
ATOM 5167 CD1 ILE D 72 7.317 -13. 689 -22. 453 1. 00 25.30ATOM 5167 CD1 ILE D 72 7.317 -13. 689 -22. 453 1. 00 25.30
ATOM 5168 C ILE D 72 4.334 -15. 755 -20. 164 1. 00 29.91ATOM 5168 C ILE D 72 4.334 -15. 755 -20. 164 1. 00 29.91
ATOM 5169 0 ILE D 72 4.961 - 16. 354 -19. 290 1. 00 28.36ATOM 5169 0 ILE D 72 4.961-16. 354 -19. 290 1. 00 28.36
ATOM 5170 N ASP D 73 3.695 -16. 377 -21. 148 1. 00 29.76ATOM 5170 N ASP D 73 3.695 -16. 377 -21. 148 1. 00 29.76
ATOM 5171 CA ASP D 73 3.788 - 17. 821 -21. 323 1. 00 30.18ATOM 5171 CA ASP D 73 3.788-17. 821 -21. 323 1. 00 30.18
ATOM 5172 CB ASP D 73 2.419 -18. 408 -21. 708 1. 00 33.58ATOM 5172 CB ASP D 73 2.419 -18. 408 -21. 708 1. 00 33.58
ATOM 5173 CG ASP D 73 1.318 -18. 056 -20. 710 1. 00 35.93ATOM 5173 CG ASP D 73 1.318 -18. 056 -20. 710 1. 00 35.93
ATOM 5174 0D1 ASP D 73 0.388 -17. 315 - 21. 098 1. 00 40.36ATOM 5174 0D1 ASP D 73 0.388 -17. 315-21. 098 1. 00 40.36
ATOM 5175 0D2 ASP D 73 1.376 -18. 519 -19. 549 1. 00 33.96ATOM 5175 0D2 ASP D 73 1.376 -18. 519 -19. 549 1. 00 33.96
ATOM 5176 C ASP D 73 4.802 - 18. 131 -22. 426 1. 00 30.69ATOM 5176 C ASP D 73 4.802-18. 131 -22. 426 1. 00 30.69
ATOM 5177 0 ASP D 73 4.842 -17. 446 - 23. 453 1. 00 30.29ATOM 5177 0 ASP D 73 4.842 -17. 446-23. 453 1. 00 30.29
ATOM 5178 N GLN D 74 5.614 -19. 165 -22. 208 1. 00 29.18ATOM 5178 N GLN D 74 5.614 -19. 165 -22. 208 1. 00 29.18
ATOM 5179 CA GLN D 74 6.625 -19. 574 -23. 181 1. 00 29.17ATOM 5179 CA GLN D 74 6.625 -19. 574 -23. 181 1. 00 29.17
ATOM 5180 CB GLN D 74 8.007 -19. 083 -22. 743 1. ,00 30.65ATOM 5180 CB GLN D 74 8.007 -19. 083 -22. 743 1., 00 30.65
ATOM 5181 CG GLN D 74 8.141 -17. 579 -22. 674 1. ,00 33.29ATOM 5181 CG GLN D 74 8.141 -17. 579 -22. 674 1., 00 33.29
ATOM 5182 CD GLN D 74 8.283 -16. 948 - 24. 040 1. 00 35.11ATOM 5182 CD GLN D 74 8.283 -16. 948-24. 040 1. 00 35.11
ATOM 5183 0E1 GLN D 74 9.396 -16. 777一 24. 543 1. ,00 39.17ATOM 5183 0E1 GLN D 74 9.396 -16.777 1 24.543 1., 00 39.17
ATOM 5184 NE2 GLN D 74 7.158 -16. 600 -24. 653 1. ,00 34.02ATOM 5184 NE2 GLN D 74 7.158 -16. 600 -24. 653 1., 00 34.02
ATOM 5185 C GLN D 74 6.688 - 21. 088 -23. 373 1. ,00 27.83ATOM 5185 C GLN D 74 6.688-21. 088 -23. 373 1., 00 27.83
ATOM 5186 0 GLN D 74 6.466 -21. 853 - 22. 434 1. .00 25.42ATOM 5186 0 GLN D 74 6.466 -21. 853-22. 434 1. .00 25.42
ATOM 5187 N ILE D 75 7.003 -21. 517 -24. 591 1. .00 27.38ATOM 5187 N ILE D 75 7.003 -21. 517 -24. 591 1. .00 27.38
ATOM 5188 CA ILE D 75 7.387 -22. 908 -24. 823 1. .00 27.07ATOM 5188 CA ILE D 75 7.387 -22. 908 -24. 823 1. .00 27.07
ATOM 5189 CB ILE D 75 6.818 -23. 446 -26. 139 1. .00 25.07ATOM 5189 CB ILE D 75 6.818 -23. 446 -26. 139 1. .00 25.07
ATOM 5190 CG2 ILE D 75 5.334 -23. 204 -26. 183 1, .00.24.07ATOM 5190 CG2 ILE D 75 5.334 -23. 204 -26. 183 1, .00.24.07
ATOM 5191 CG1 ILE D 75 7.547 -22. 805 -27. 322 1, .00 23.09ATOM 5191 CG1 ILE D 75 7.547 -22. 805 -27. 322 1, .00 23.09
ATOM 5192 CD1 ILE D 75 7.182 -23. 392 -28. 669 1, .00 23.75ATOM 5192 CD1 ILE D 75 7.182 -23. 392 -28. 669 1, .00 23.75
ATOM 5193 C ILE D 75 8.908 - 23. 038一 24. 888 1 .00 27.47ATOM 5193 C ILE D 75 8.908-23. 038 1 24. 888 1 .00 27.47
ATOM 5194 0 ILE D 75 9.624 -22. 044 -24. 931 1, .00 28.07ATOM 5194 0 ILE D 75 9.624 -22. 044 -24. 931 1, .00 28.07
ATOM 5195 N LYS D 76 9.401 -24. 270 -24. 890 1 .00 30.06 ATOM 5196 CA LYS D 76 10. 833 - 24. 507 -25. 053 1. 00 31. 82 CATOM 5195 N LYS D 76 9.401 -24. 270 -24. 890 1 .00 30.06 ATOM 5196 CA LYS D 76 10. 833-24. 507 -25. 053 1. 00 31. 82 C
ATOM 5197 CB LYS D 76 11. 298 -25. 598 -24. 086 1. 00 34. 67 CATOM 5197 CB LYS D 76 11. 298 -25. 598 -24. 086 1. 00 34. 67 C
ATOM 5198 C6 LYS D 76 10. 893 -25. 377 - 22. 634 1. 00 38. 34 CATOM 5198 C6 LYS D 76 10. 893 -25. 377-22. 634 1. 00 38. 34 C
ATOM 5199 CD LYS D 76 12. 049 -24. 857 -21. 788 1. 00 41. 49 CATOM 5199 CD LYS D 76 12. 049 -24. 857 -21. 788 1. 00 41. 49 C
ATOM 5200 CE LYS D 76 11. 752 -24. 998 -20. 295 1. 00 42. 59 CATOM 5200 CE LYS D 76 11. 752 -24. 998 -20. 295 1. 00 42. 59 C
ATOM 5201 NZ LYS D 76 11. 288 -26. 379 -19. 957 1. 00 42. 94 ΝATOM 5201 NZ LYS D 76 11. 288 -26. 379 -19. 957 1. 00 42. 94 Ν
ATOM 5202 C LYS D 76 11. 127 -24. 937 -26. 491 1. 00 30. 50 CATOM 5202 C LYS D 76 11. 127 -24. 937 -26. 491 1. 00 30. 50 C
ATOM 5203 0 LYS D 76 -26. 126 -26. 788 1. 00 30. 52 0ATOM 5203 0 LYS D 76 -26. 126 -26. 788 1. 00 30. 52 0
ATOM 5204 N 6LY D 77 11. 350 - 23. 969 -27. 374 1. 00 28. 35 ΝATOM 5204 N 6LY D 77 11. 350-23. 969 -27. 374 1. 00 28. 35 Ν
ATOM 5205 CA GLY D 77 11. 480 -24. 276 -28. 786 1. 00 27. 44 CATOM 5205 CA GLY D 77 11. 480 -24. 276 -28. 786 1. 00 27. 44 C
ATOM 5206 C GLY D 77 12. 685 - 25. 136 -29. 109 1. 00 28. 65 CATOM 5206 C GLY D 77 12. 685-25. 136 -29. 109 1. 00 28. 65 C
ATOM 5207 0 GLY D 77 12. 624 - 25. 998 -29. 989 1. 00 27. 42 0ATOM 5207 0 GLY D 77 12. 624-25. 998 -29. 989 1. 00 27. 42 0
ATOM 5208 N LYS D 78 13. 782 -24. 907 - 28. 395 1. 00 29. 26 ΝATOM 5208 N LYS D 78 13. 782 -24. 907-28. 395 1. 00 29. 26 Ν
ATOM 5209 CA LYS D 78 15. 004 - 25. 672 -28. 603 1. 00 30. 35 CATOM 5209 CA LYS D 78 15. 004-25. 672 -28. 603 1. 00 30. 35 C
ATOM 5210 CB LYS D 78 16. 129 -25. 158 -27. 694 1. 00 32. 11 CATOM 5210 CB LYS D 78 16. 129 -25. 158 -27. 694 1. 00 32. 11 C
ATOM 5211 C6 LYS D 78 16. 614 -23. 740 -27. 991 1. 00 36. 12 CATOM 5211 C6 LYS D 78 16. 614 -23. 740 -27. 991 1. 00 36. 12 C
ATOM 5212 CD LYS D 78 18. 034 - 23. 521 - 27. 445 1. 00 39. 65 CATOM 5212 CD LYS D 78 18. 034-23. 521-27. 445 1. 00 39. 65 C
ATOM 5213 CE LYS D 78 18. 338 -22. 039 -27. 205 1. 00 43. 23 CATOM 5213 CE LYS D 78 18. 338 -22. 039 -27. 205 1. 00 43. 23 C
ATOM 5214 NZ LYS D 78 19. 798 -21. 694 -27. 250 1. 00 .42. 56 ΝATOM 5214 NZ LYS D 78 19. 798 -21. 694 -27. 250 1. 00 .42. 56 Ν
ATOM 5215 C LYS D 78 14. 780 - 27. 158 -28. 333 1. 00 29. 24 CATOM 5215 C LYS D 78 14. 780-27. 158 -28. 333 1. 00 29. 24 C
ATOM 5216 0 LYS D 78 15. 357 -28. 002 -29. 011 1. , 00 31. 95 0ATOM 5216 0 LYS D 78 15. 357 -28. 002 -29. 011 1., 00 31. 95 0
ATOM 5217 N LYS D 79 13. 944 -27. 478 - 27. 351 1. , 00 26. 85 ΝATOM 5217 N LYS D 79 13. 944 -27. 478-27. 351 1., 00 26. 85 Ν
ATOM . 5218 CA LYS D 79 1'3. 693 -28. 870 -27. 000 1. , 00 24. 55 CATOM. 5218 CA LYS D 79 1'3. 693 -28. 870 -27. 000 1., 00 24. 55 C
ATOM 5219 CB LYS D 79 13. 043 - 28. 978 -25. 612 1. . 00 26. 32 CATOM 5219 CB LYS D 79 13. 043-28. 978 -25. 612 1.. 00 26. 32 C
ATOM 5220 C6 LYS D 79 13. 845 -28. 394 -24. 447 1 , . 00 28. 98 CATOM 5220 C6 LYS D 79 13. 845 -28. 394 -24. 447 1,. 00 28. 98 C
ATOM 5221 CD LYS 0 79 15. 274 -28. 029 -24. 823 1. . 00 33. 15 CATOM 5221 CD LYS 0 79 15. 274 -28. 029 -24. 823 1.. 00 33. 15 C
ATOM 5222 CE LYS D 79 16. 239 -29. 191 -24. 570 1 , . 00 35. 82 CATOM 5222 CE LYS D 79 16. 239 -29. 191 -24. 570 1,. 00 35. 82 C
ATOM 5223 NZ LYS D 79 17. 669 -28. 758 -24. 632 1 , 00 36. 87 ΝATOM 5223 NZ LYS D 79 17. 669 -28. 758 -24. 632 1, 00 36. 87 Ν
ATOM 5224 C LYS D 79 12. 781 -29. 536 -28. 029 1 , . 00 23. 06 CATOM 5224 C LYS D 79 12. 781 -29. 536 -28. 029 1,. 00 23. 06 C
ATOM 5225 0 LYS D 79 12. 370 -30. 685 -27. 855 1 . 00 22. 09 0ATOM 5225 0 LYS D 79 12. 370 -30. 685 -27. 855 1. 00 22. 09 0
ATOM 5226 N I LE D 80 12. 454 -28. 816 -29. 094 1 ■ 00 20. 20 ΝATOM 5226 N I LE D 80 12. 454 -28. 816 -29. 094 1 ■ 00 20. 20 Ν
ATOM 5227 CA I LE D 80 11. 684 -29. 403 -30. 182 1 . 00 23. 66 CATOM 5227 CA I LE D 80 11. 684 -29. 403 -30. 182 1. 00 23. 66 C
ATOM 5228 CB I LE D 80 10. 651 -28. 395 -30. 756 1 . 00 25. 86 CATOM 5228 CB I LE D 80 10. 651 -28. 395 -30. 756 1. 00 25. 86 C
ATOM 5229 C62 I LE D 80 9. 854 -29. 044 -31. 873 1 . 00 20. 36 CATOM 5229 C62 I LE D 80 9. 854 -29. 044 -31. 873 1. 00 20. 36 C
ATOM 5230 CG1 I LE D 80 9. 685 -27. 944 -29. 662 1 . 00 25. 33 CATOM 5230 CG1 I LE D 80 9. 685 -27. 944 -29. 662 1. 00 25. 33 C
ATOM 5231 CD1 I LE D 80 8. 533 -28. 901 -29. 445 1 . 00 27. 99 C ATOM 5232 C !LE D 80 12.647 -29.818 -31.294 1.0023.80 CATOM 5231 CD1 I LE D 80 8. 533 -28. 901 -29. 445 1. 00 27. 99 C ATOM 5232 C! LE D 80 12.647 -29.818 -31.294 1.0023.80 C
ATOM 5233 0 ILE D 80 13.577 -29.081 - 31. 632 1. 00 23.75 0ATOM 5233 0 ILE D 80 13.577 -29.081-31. 632 1.00 23.75 0
ATOM 5234 N THR D 81 12.439 -31. 003 -31. 854 1. 00 25.08 NATOM 5234 N THR D 81 12.439 -31. 003 -31. 854 1. 00 25.08 N
ATOM 5235 CA THR D 81 13.286 -31. 461 -32.952 1. 00 24.73 CATOM 5235 CA THR D 81 13.286 -31. 461 -32.952 1. 00 24.73 C
ATOM 5236 CB THR D 81 14.111 -32.712 -32.570 1. 00 25.83 CATOM 5236 CB THR D 81 14.111 -32.712 -32.570 1. 00 25.83 C
ATOM 5237 061 THR D 81 14.951 -32.417 -31. 445 1. 00 26.95 0ATOM 5237 061 THR D 81 14.951 -32.417 -31. 445 1. 00 26.95 0
ATOM 5238 C62 THR D 81 14.990 -33.143 -33. 746 1. 00 22.92 CATOM 5238 C62 THR D 81 14.990 -33.143 -33. 746 1. 00 22.92 C
ATOM 5239 C THR D 81 12.455 -31. 799一 34. 170 1. 00 23.76 CATOM 5239 C THR D 81 12.455 -31.799 One 34.170 1.00 23.76 C
ATOM 5240 0 THR D 81 11. 532 -32.612 -34. 098 1. 00 23.44 0ATOM 5240 0 THR D 81 11. 532 -32.612 -34. 098 1.00 23.44 0
ATOM 5241 N VAL D 82 12.776 -31. 170 -35. 294 1. 00 21. 11 NATOM 5241 N VAL D 82 12.776 -31. 170 -35. 294 1. 00 21. 11 N
ATOM 5242 CA VAL D 82 12.135 -31. 532 -36. 544 1. 00 21. 50 CATOM 5242 CA VAL D 82 12.135 -31. 532 -36. 544 1. 00 21. 50 C
ATOM 5243 CB VAL D 82 11. 987 -30.318 -37. 456 1. 00 22.92 CATOM 5243 CB VAL D 82 11. 987 -30.318 -37. 456 1. 00 22.92 C
ATOM 5244 C61 VAL D 82 11. 140 -30.676 -38. 658 1. 00 20.60 CATOM 5244 C61 VAL D 82 11. 140 -30.676 -38. 658 1. 00 20.60 C
ATOM 5245 C62 VAL D 82 11. 391 -29.174 - 36. 680 1. 00 28.44 CATOM 5245 C62 VAL D 82 11. 391 -29.174-36. 680 1. 00 28.44 C
ATOM 5246 C VAL D 82 13.004 -32.564 -37. 248 1. 00 21. 42 CATOM 5246 C VAL D 82 13.004 -32.564 -37. 248 1. 00 21. 42 C
ATOM 5247 0 VAL D 82 14.215 - 32.378 -37. 372 1. 00 19.87 0ATOM 5247 0 VAL D 82 14.215-32.378 -37. 372 1. 00 19.87 0
ATOM 5248 N VAL D 83 12.375 - 33.642 -37. 709 1. 00 21. 45 NATOM 5248 N VAL D 83 12.375-33.642 -37. 709 1. 00 21. 45 N
ATOM 5249 CA VAL D 83 13.082 -34.780 -38. 285 1. 00 19.30 CATOM 5249 CA VAL D 83 13.082 -34.780 -38. 285 1. 00 19.30 C
ATOM 5250 CB VAL D 83 12.931 - 36.035 -37. 387 1. ,00 20.30 CATOM 5250 CB VAL D 83 12.931-36.035 -37. 387 1., 00 20.30 C
ATOM 5251 CG1 VAL D 83 13.682 - 37.220 - 38. 007 1. ,00 21. 02 CATOM 5251 CG1 VAL D 83 13.682-37.220-38. 007 1., 00 21. 02 C
ATOM 5252 CG2 VAL D 83 13.478 -35.744 -35. 989 1. ,00 19.50 CATOM 5252 CG2 VAL D 83 13.478 -35.744 -35. 989 1., 00 19.50 C
ATOM 5253 C VAL D 83 12.548 -35.100 -39. 679 1, .00 19.25 CATOM 5253 C VAL D 83 12.548 -35.100 -39. 679 1, .00 19.25 C
ATOM 5254 0 VAL D 83 11. 647 -35.922 -39.846 1, .00 20. 53 0ATOM 5254 0 VAL D 83 11. 647 -35.922 -39.846 1, .00 20. 53 0
ATOM 5255 N PRO D 84 13.092 - 34.438 - 40.702 1. .00 17. 88 NATOM 5255 N PRO D 84 13.092-34.438-40.702 1. .00 17. 88 N
ATOM 5256 CD PRO D 84 14. 026 - 33. 296 -40. 637 1. .00 17. 38 CATOM 5256 CD PRO D 84 14. 026-33. 296 -40. 637 1. .00 17. 38 C
ATOM 5257 CA PRO D 84 12. 676 - 34. 740 -42. 071 1, .00 16. 89 CATOM 5257 CA PRO D 84 12. 676-34. 740 -42. 071 1, .00 16. 89 C
ATOM 5258 CB PRO D 84 13. 113 -33. 508 -42. 857 1 .00 15. 88 CATOM 5258 CB PRO D 84 13. 113 -33. 508 -42. 857 1 .00 15. 88 C
ATOM 5259 C6 PRO D 84 14. 301 - 32. 985 - 42. 095 1, .00 16. 62 CATOM 5259 C6 PRO D 84 14. 301-32. 985-42. 095 1, .00 16. 62 C
ATOM 5260 C PRO D 84 13. 329 -36. 021 -42. ,594 1 .00 18. 84 CATOM 5260 C PRO D 84 13. 329 -36. 021 -42., 594 1 .00 18. 84 C
ATOM 5261 0 PRO D 84 14. 536 -36. 220 - 42. ,443 1 .00 16. 36 0ATOM 5261 0 PRO D 84 14. 536 -36. 220-42., 443 1 .00 16. 36 0
ATOM 5262 N ILE D 85 12. 523 -36. 884 -43. .209 1 ■ 00 19. 08 NATOM 5262 N ILE D 85 12. 523 -36. 884 -43. .209 1 ■ 00 19. 08 N
ATOM 5263 CA ILE D 85 13. 046 -38. 049 -43. ,896 1 ■ 00 19. 68 CATOM 5263 CA ILE D 85 13. 046 -38. 049 -43., 896 1 ■ 00 19. 68 C
ATOM 5264 CB ILE D 85 11. 994 - 39. 176 -43. .956 1 .00 19. 66 CATOM 5264 CB ILE D 85 11. 994-39. 176 -43..956 1 .00 19. 66 C
ATOM 5265 CG2 E D 85 12. 624一 40. 428 - 44. .538 1 .00 17. 45 CATOM 5265 CG2 E D 85 12. 624 1 40. 428-44. .538 1 .00 17. 45 C
ATOM 5266 CG1 ILE D 85 11. 448 -39. 470 -42, .559 1 .00 18. 16 CATOM 5266 CG1 ILE D 85 11. 448 -39. 470 -42, .559 1 .00 18. 16 C
ATOM 5267 GD1 ILE D 85 10. 332 -40. .495 -42, .539 1 .00 17. 62 C ATOM 5268 C ILE D 85 13.444 -37.675 -45.331 1.00 20.49 CATOM 5267 GD1 ILE D 85 10. 332 -40..495 -42, .539 1 .00 17. 62 C ATOM 5268 C ILE D 85 13.444 -37.675 -45.331 1.00 20.49 C
ATOM 5269 0 ILE D 85 12.600 -37.276 -46.131 1. 00 20.33 0ATOM 5269 0 ILE D 85 12.600 -37.276 -46.131 1.00 20.33 0
ATOM 5270 N LEU D 86 14.731 -37.811 -45.646 1. 00 22.04 NATOM 5270 N LEU D 86 14.731 -37.811 -45.646 1. 00 22.04 N
ATOM 5271 CA LEU D 86 15.238 -37.557 -46.993 1. 00 22.39 CATOM 5271 CA LEU D 86 15.238 -37.557 -46.993 1.00 22.39 C
ATOM 5272 CB LEU D 86 16.735 -37.803 -47.047 1. 00 20.39 CATOM 5272 CB LEU D 86 16.735 -37.803 -47.047 1. 00 20.39 C
ATOM 5273 CG LEU D 86 17.559 -36.798 -46.264 1. 00 20.02 CATOM 5273 CG LEU D 86 17.559 -36.798 -46.264 1.00 20.02 C
ATOM 5274 CD1 LEU D 86 19.019 -37.208 -46. 303 1. 00 19.60 CATOM 5274 CD1 LEU D 86 19.019 -37.208 -46. 303 1. 00 19.60 C
ATOM 5275 CD2 LEU D 86 17.354 -35.412 -46. 865 1. 00 17.73 CATOM 5275 CD2 LEU D 86 17.354 -35.412 -46. 865 1. 00 17.73 C
ATOM 5276 C LEU D 86 14.573 -38.474 - 47. 986 1. 00 23.03 CATOM 5276 C LEU D 86 14.573 -38.474-47. 986 1.00 23.03 C
ATOM 5277 0 LEU D 86 14.336 -39.627 -47. 678 1. 00 25.78 0ATOM 5277 0 LEU D 86 14.336 -39.627 -47. 678 1. 00 25.78 0
ATOM 5278 N ARG D 87 14.273 - 37.970一 49. 177 1. 00 24.16 NATOM 5278 N ARG D 87 14.273-37.970 One 49. 177 1.00 24.16 N
ATOM 5279 CA ARG D 87 14.485 -36.566 - 49. 519 1. 00 23.64 CATOM 5279 CA ARG D 87 14.485 -36.566-49. 519 1. 00 23.64 C
ATOM 5280 CB ARG D 87 14.786 - 36.430 -51. 009 1. 00 24.40 CATOM 5280 CB ARG D 87 14.786-36.430 -51. 009 1.00 24.40 C
ATOM 5281 CG ARG D 87 15.867 -37.341 -51. 539 1. 00 24.60 CATOM 5281 CG ARG D 87 15.867 -37.341 -51. 539 1. 00 24.60 C
ATOM 5282 CD ARG D 87 16.063 -37.116 - 53. 026 1. 00 18.01 CATOM 5282 CD ARG D 87 16.063 -37.116-53. 026 1.00 18.01 C
ATOM 5283 NE ARG D 87 14.947 - 37.675 - 53. 774 1. 00 20.19 NATOM 5283 NE ARG D 87 14.947-37.675-53. 774 1. 00 20.19 N
ATOM 5284 CZ ARG 0 87 14.597 -37.295 -54. 996 1. 00 17.03 CATOM 5284 CZ ARG 0 87 14.597 -37.295 -54. 996 1.00 17.03 C
ATOM 5285 NH1 ARG D 87 15.279 -36.344 - 55. 616 1. 00 18.73 NATOM 5285 NH1 ARG D 87 15.279 -36.344-55. 616 1. 00 18.73 N
ATOM 5286 NH2 ARG D 87 13.564 -37.870 -55. 593 1. 00 .15.25 NATOM 5286 NH2 ARG D 87 13.564 -37.870 -55. 593 1. 00 .15.25 N
ATOM 5287 C ARG D 87 13.244 -35.731 -49. 213 1. 00 23.19 CATOM 5287 C ARG D 87 13.244 -35.731 -49. 213 1.00 23.19 C
ATOM 5288 0 ARG D 87 13.343 -34.601 -48. 743 1. ,00 23.18 0ATOM 5288 0 ARG D 87 13.343 -34.601 -48. 743 1., 00 23.18 0
ATOM 5289 N ALA D 88 12.079 -36.304 —49. 497 1. ,00 23.84 NATOM 5289 N ALA D 88 12.079 -36.304 —49. 497 1., 00 23.84 N
ATOM 5290 CA ALA 0 88 10.831 -35.560 -49.570 1. .00 24.54 CATOM 5290 CA ALA 0 88 10.831 -35.560 -49.570 1. .00 24.54 C
ATOM 5291 CB ALA D 88 9.694 -36.503 -49. 935 1. ,00 25.50 CATOM 5291 CB ALA D 88 9.694 -36.503 -49. 935 1., 00 25.50 C
ATOM 5292 C ALA D 88 10.489 -34.802 - 48. 294 1. ,00 25.83 CATOM 5292 C ALA D 88 10.489 -34.802-48. 294 1., 00 25.83 C
ATOM 5293 0 ALA D 88 9.867 -33.751 -48. 349 1. .00 27.26 0ATOM 5293 0 ALA D 88 9.867 -33.751 -48. 349 1. .00 27.26 0
ATOM 5294 N GLY D 89 10.892 - 35.335 -47. 147 1. .00 27.05 NATOM 5294 N GLY D 89 10.892-35.335 -47. 147 1. .00 27.05 N
ATOM 5295 CA 6LY D 89 10.650 -34.641 -45. 899 1. .00 26.97 CATOM 5295 CA 6LY D 89 10.650 -34.641 -45. 899 1. .00 26.97 C
ATOM 5296 C GLY D 89 11.176 - 33, 212 -45. 890 1, .00 29.18 CATOM 5296 C GLY D 89 11.176-33, 212 -45. 890 1, .00 29.18 C
ATO 5297 0 GLY D 89 10.636 -32.361 -45. 176 1, .00 28.83 0ATO 5297 0 GLY D 89 10.636 -32.361 -45. 176 1, .00 28.83 0
ATOM 5298 N LEU D 90 12.219 -32.932 -46. 670 1, .00 26.50 NATOM 5298 N LEU D 90 12.219 -32.932 -46. 670 1, .00 26.50 N
ATOM 5299 CA LEU D 90 12.814 -31.599 -46. 656 1 .00 26.91 CATOM 5299 CA LEU D 90 12.814 -31.599 -46. 656 1 .00 26.91 C
ATOM 5300 CB LEU D 90 14.150 -31.584 -47. 405 1 .00 26.73 CATOM 5300 CB LEU D 90 14.150 -31.584 -47. 405 1 .00 26.73 C
ATOM 5301 CG LEU D 90 15.351 -32.057 -46. 582 1 .00 27.12 CATOM 5301 CG LEU D 90 15.351 -32.057 -46. 582 1 .00 27.12 C
ATOM 5302 CD1 LEU D 90 16.621 -31.796 -47. ,352 1 ■ 00 28.19 CATOM 5302 CD1 LEU D 90 16.621 -31.796 -47., 352 1 ∎ 00 28.19 C
ATOM 5303 CD2 LEU D 90 15.394 -31.333 -45. ,244 1 .00 29.20 C ATOM 5304 C LEU D 90 11.894 - 30.523 -47.233 1.00 26.25 CATOM 5303 CD2 LEU D 90 15.394 -31.333 -45., 244 1 .00 29.20 C ATOM 5304 C LEU D 90 11.894-30.523 -47.233 1.00 26.25 C
ATOM 5305 0 LEU D 90 12.082 29.342 - 46.971 1.00 26.44 0ATOM 5305 0 LEU D 90 12.082 29.342-46.971 1.00 26.44 0
ATOM 5306 N GLY D 91 10.894 -30.934 -48.005 1.00 26.09 NATOM 5306 N GLY D 91 10.894 -30.934 -48.005 1.00 26.09 N
ATOM 5307 CA GLY D 91 9.934 -29.987一 48.539 1.00 25.59 CATOM 5307 CA GLY D 91 9.934 -29.987 1 48.539 1.00 25.59 C
ATOM 5308 C GLY D 91 8.946 -29.512 —47.492 1.00 26.88 CATOM 5308 C GLY D 91 8.946 -29.512 --47.492 1.00 26.88 C
ATOM 5309 0 GLY D 91 8.300 -28.486 -47.659 1.00 27.16 0ATOM 5309 0 GLY D 91 8.300 -28.486 -47.659 1.00 27.16 0
ATOM 5310 N MET D 92 8.825一 30.256 -46.402 1.00 28.05 NATOM 5310 N MET D 92 8.825 One 30.256 -46.402 1.00 28.05 N
ATOM 5311 CA MET D 92 7.890 - 29.898 -45.341 1.00 27.25 CATOM 5311 CA MET D 92 7.890-29.898 -45.341 1.00 27.25 C
ATOM 5312 CB MET D 92 7.176 -31.153 -44.813 1.00 26.93 CATOM 5312 CB MET D 92 7.176 -31.153 -44.813 1.00 26.93 C
ATOM 5313 GG MET D 92 6.141 -31.737 -45.780 1.00 26.29 CATOM 5313 GG MET D 92 6.141 -31.737 -45.780 1.00 26.29 C
ATOM 5314 SD MET D 92 5.520 - 33.374 -45.302 1.00 29.00 SATOM 5314 SD MET D 92 5.520-33.374 -45.302 1.00 29.00 S
ATOM 5315 ,CE MET D 92 4.365 -32.947 -43.948 1.00 24.42 CATOM 5315, CE MET D 92 4.365 -32.947 -43.948 1.00 24.42 C
ATOM 5316 C MET D 92 8.615 -29.196 -44.201 1.00 26.60 CATOM 5316 C MET D 92 8.615 -29.196 -44.201 1.00 26.60 C
ATOM 5317 0 MET D 92 7.992 -28.560 -43.361 1.00 26.87 0ATOM 5317 0 MET D 92 7.992 -28.560 -43.361 1.00 26.87 0
ATOM 5318 N MET D 93 9.936 -29.302 -44.184 1.00 26.06 NATOM 5318 N MET D 93 9.936 -29.302 -44.184 1.00 26.06 N
ATOM 5319 CA MET D 93 10.714 - 28.846 -43.046 1.00 26.20 CATOM 5319 CA MET D 93 10.714-28.846 -43.046 1.00 26.20 C
ATOM 5320 CB MET D 93 12.212 -29.097 -43.285 1.00 27.07 CATOM 5320 CB MET D 93 12.212 -29.097 -43.285 1.00 27.07 C
ATOM 5321 CG MET D 93 13.076 -28.868 -42.046 1.00 26.47 CATOM 5321 CG MET D 93 13.076 -28.868 -42.046 1.00 26.47 C
ATOM 5322 SD MET D 93 14.838 -29.053 -42.326 1.00 30.90 SATOM 5322 SD MET D 93 14.838 -29.053 -42.326 1.00 30.90 S
ATOM 5323 CE MET D 93 15.069 - 28.226 -43.884 1.00 25.92 CATOM 5323 CE MET D 93 15.069-28.226 -43.884 1.00 25.92 C
ATOM 5324 C MET D 93 10.488 -27.371 -42.723 1.00 26.76 CATOM 5324 C MET D 93 10.488 -27.371 -42.723 1.00 26.76 C
ATOM 5325 0 MET D 93 10.273 -27.019 -41.563 1.00 28.49 0ATOM 5325 0 MET D 93 10.273 -27.019 -41.563 1.00 28.49 0
ATOM 5326 N ASP D 94 TO.542一 26.508 -43.737 1.00 26.06 NATOM 5326 N ASP D 94 TO.542 1 26.508 -43.737 1.00 26.06 N
ATOM 5327 CA ASP D 94 10.447 -25.068 -43.505 1.00 25.30 CATOM 5327 CA ASP D 94 10.447 -25.068 -43.505 1.00 25.30 C
ATOM 5328 CB ASP D 94 10.630 -24.288 -44.813 1.00 27.64 CATOM 5328 CB ASP D 94 10.630 -24.288 -44.813 1.00 27.64 C
ATOM 5329 CG ASP D 94 12.081 -24.214 -45.254 1 · 00 30.75 CATOM 5329 CG ASP D 94 12.081 -24.214 -45.254 1 00 30.75 C
ATOM 5330 0D1 ASP D 94 12.322 -23.712 -46.373 1.00 30.78 0ATOM 5330 0D1 ASP D 94 12.322 -23.712 -46.373 1.00 30.78 0
ATOM 5331 0D2 ASP D 94 12.975，24.653 -44.491 1.00 32.45 0ATOM 5331 0D2 ASP D 94 12.975, 24.653 -44.491 1.00 32.45 0
ATOM 5332 C ASP D 94 9.110一 24, 687 -42.891 1.00 25.06 CATOM 5332 C ASP D 94 9.110 1 24, 687 -42.891 1.00 25.06 C
ATOM 5333 0 ASP D 94 9.041 -23.791 -42.048 1.00 23.81 0ATOM 5333 0 ASP D 94 9.041 -23.791 -42.048 1.00 23.81 0
ATOM 5334 N GLY D 95 8.052 -25.367 - 43.327 1.00 24.81 NATOM 5334 N GLY D 95 8.052 -25.367-43.327 1.00 24.81 N
ATOM 5335 CA GLY D 95 6.746 -25.152 -42.741 1.00 24.46 CATOM 5335 CA GLY D 95 6.746 -25.152 -42.741 1.00 24.46 C
ATOM 5336 C GLY D 95 6.761 -25.400 -41.241 1.00 25.16 CATOM 5336 C GLY D 95 6.761 -25.400 -41.241 1.00 25.16 C
ATOM 5337 0 GLY D 95 6.203 -24.613 -40.474 1.00 26.20 0ATOM 5337 0 GLY D 95 6.203 -24.613 -40.474 1.00 26.20 0
ATOM 5338 N VAL D 96 7.403 -26.483 -40.810 1.00 21.26 NATOM 5338 N VAL D 96 7.403 -26.483 -40.810 1.00 21.26 N
ATOM 5339 CA VAL D 96 7.436 - 26.807 -39.390 1.00 20.76 C JP2007/071755 ATOM 5339 CA VAL D 96 7.436-26.807 -39.390 1.00 20.76 C JP2007 / 071755
ATOM 5340 CB VAL D 96 8.117 - 28. 179 -39. 112 1. 00 21.16 CATOM 5340 CB VAL D 96 8.117-28. 179 -39. 112 1. 00 21.16 C
ATOM 5341 CG1 VAL D 96 8.037 - 28. 510 -37. 638 1. 00 16.53 CATOM 5341 CG1 VAL D 96 8.037-28. 510 -37. 638 1. 00 16.53 C
ATOM 5342 CG2 VAL D 96 7.470 -29. 265 -39. 938 1. 00 21.70 CATOM 5342 CG2 VAL D 96 7.470 -29. 265 -39. 938 1. 00 21.70 C
ATOM 5343 C VAL D 96 8.240 -25. 732 -38. 679 1. 00 22.76 CATOM 5343 C VAL D 96 8.240 -25. 732 -38. 679 1. 00 22.76 C
ATOM 5344 0 VAL D 96 7.840 -25. 236 - 37. 628 1. 00 22.47 0ATOM 5344 0 VAL D 96 7.840 -25. 236-37. 628 1. 00 22.47 0
ATOM 5345 N LEU D 97 9.379 -25. 378 -39. 265 1. 00 23.07 NATOM 5345 N LEU D 97 9.379 -25. 378 -39. 265 1. 00 23.07 N
ATOM 5346 CA LEU D 97 10.293 -24. 415 -38. 666 1. 00 26.17 CATOM 5346 CA LEU D 97 10.293 -24. 415 -38. 666 1. 00 26.17 C
ATOM 5347 CB LEU D 9フ 11.609 -24. 381 -39. 458 1. 00 28.30 CATOM 5347 CB LEU D 9F 11.609 -24. 381 -39. 458 1. 00 28.30 C
ATOM 5348 CG LEU D 97 12.522 -25. 607 -39. 370 1. 00 27.01 CATOM 5348 CG LEU D 97 12.522 -25. 607 -39. 370 1. 00 27.01 C
ATOM 5349 CD1 LEU D 97 13.755 - 25. 379 - 40. 231 1. 00 26.40 CATOM 5349 CD1 LEU D 97 13.755-25. 379-40. 231 1. 00 26.40 C
ATOM 5350 CD2 LEU D 97 12.916 -25. 847 -37. 924 1. 00 26.41 CATOM 5350 CD2 LEU D 97 12.916 -25. 847 -37. 924 1. 00 26.41 C
ATOM 5351 C LEU D 97 9.724 -22. 995 - 38. 575 1. 00 26.46 CATOM 5351 C LEU D 97 9.724 -22. 995-38. 575 1. 00 26.46 C
ATOM 5352 0 LEU D 97 10.148 -22. 205 -37. 729 1. 00 25.84 0ATOM 5352 0 LEU D 97 10.148 -22. 205 -37. 729 1. 00 25.84 0
ATOM 5353 N 6LU D 98 8.776 -22. 668 - 39. 446 1. 00 27.27 NATOM 5353 N 6LU D 98 8.776 -22. 668-39. 446 1. 00 27.27 N
ATOM 5354 CA GLU D 98 8.121 -21. 367 -39. 383 1. 00 28.99 CATOM 5354 CA GLU D 98 8.121 -21. 367 -39. 383 1. 00 28.99 C
ATOM 5355 CB GLU D 98 7.150 -21. 199 -40. 555 1. 00 32.24 CATOM 5355 CB GLU D 98 7.150 -21. 199 -40. 555 1. 00 32.24 C
ATOM 5356 CG GLU D 98 7.805 -20. 747 -41. 846 1. 00 41.45 CATOM 5356 CG GLU D 98 7.805 -20. 747 -41. 846 1. 00 41.45 C
ATOM 5357 CD GLU D 98 6.873 -20. 860 - 43. 045 1. ,00 44.96 CATOM 5357 CD GLU D 98 6.873 -20. 860-43. 045 1., 00 44.96 C
ATOM 5358 0E1 GLU D 98 5.686 -21. 210 -42. 847 1. .00 48.15 0ATOM 5358 0E1 GLU D 98 5.686 -21. 210 -42. 847 1. .00 48.15 0
ATOM 5359 0E2 GLU D 98 7.330 -20. 603 -44. 183 1. .00 46.76 0ATOM 5359 0E2 GLU D 98 7.330 -20. 603 -44. 183 1. .00 46.76 0
ATOM 5360 C GLU D 98 7.362 -21. 203 -38. 060 1. .00 27.69 CATOM 5360 C GLU D 98 7.362 -21. 203 -38. 060 1. .00 27.69 C
ATOM 5361 0 GLU D 98 7.310 - 20. 104 - 37. 495 1. .00 26.29 0ATOM 5361 0 GLU D 98 7.310-20. 104-37. 495 1. .00 26.29 0
ATOM 5362 N ASN D 99 6.784 -22. 303 -37'.581 1. .00 23.97 NATOM 5362 N ASN D 99 6.784 -22. 303 -37'.581 1. .00 23.97 N
ATOM 5363 CA ASN D 99 6.086 -22. 341 - 36. 299 1. .00 23.31 CATOM 5363 CA ASN D 99 6.086 -22. 341-36. 299 1. .00 23.31 C
ATOM 5364 CB ASN D 99 5.186 -23. 572 -36. 234 1. .00 23.44 CATOM 5364 CB ASN D 99 5.186 -23. 572 -36. 234 1. .00 23.44 C
ATOM 5365 CG ASN D 99 4.008 -23. 479 -37. 168 1. .00 24.78 CATOM 5365 CG ASN D 99 4.008 -23. 479 -37. 168 1. .00 24.78 C
ATOM 5366 0D1 ASN D 99 2.912 -23. 112 - 36. 758 1, .00 30.19 0ATOM 5366 0D1 ASN D 99 2.912 -23. 112-36. 758 1, .00 30.19 0
ATOM 5367 ND2 ASN D 99 4.221 -23. 811 -38. 431 1, .00 26.43 NATOM 5367 ND2 ASN D 99 4.221 -23. 811 -38. 431 1, .00 26.43 N
ATOM 5368 C ASN D 99 7.023一 22. 360 -35. 096 1, .00 23.47 CATOM 5368 C ASN D 99 7.023 One 22. 360 -35. 096 1, .00 23.47 C
ATOM' 5369 0 ASN D 99 6.788 -21. 664 -34. 116 1, .00 22.16 0ATOM '5369 0 ASN D 99 6.788 -21. 664 -34. 116 1, .00 22.16 0
ATOM 5370 N VAL D 100 8.070 -23. 181 -35. 165 1, .00 24.71 NATOM 5370 N VAL D 100 8.070 -23. 181 -35. 165 1, .00 24.71 N
ATOM 5371 CA VAL D 100 9.004 -23. 344 -34. 055 1 .00 24.36 CATOM 5371 CA VAL D 100 9.004 -23. 344 -34. 055 1 .00 24.36 C
ATOM 5372 CB VAL D 100 8.908 -24. 762 -33. 466 1 .00 24.87 CATOM 5372 CB VAL D 100 8.908 -24. 762 -33. 466 1 .00 24.87 C
ATOM 5373 CG1 VAL D 100 9.486 - 24. 793 -32. 072 1 • 00 23.20 CATOM 5373 CG1 VAL D 100 9.486-24. 793 -32. 072 1 • 00 23.20 C
ATOM 5374 C62 VAL D 100 7.474 -25. 220 - 33. 464 1 • 00 28.91 CATOM 5374 C62 VAL D 100 7.474 -25. 220-33. 464 1 • 00 28.91 C
ATOM 5375 C VAL D 100 10.435一 23. 125 -34. 560 1 • 00 26.52 C ATOM 5376 0 VAL D 100 11.202 -24.071 -34.717 1.00 28.76 0ATOM 5375 C VAL D 100 10.435 One 23. 125 -34. 560 1 • 00 26.52 C ATOM 5376 0 VAL D 100 11.202 -24.071 -34.717 1.00 28.76 0
ATOM 5377 N PRO D 101 10.807 -21.868 -34. 827 1. 00 27.02 NATOM 5377 N PRO D 101 10.807 -21.868 -34. 827 1. 00 27.02 N
ATOM 5378 CD PRO D 101 10.000 -20.658 -34. 592 1. 00 26.39 CATOM 5378 CD PRO D 101 10.000 -20.658 -34. 592 1. 00 26.39 C
ATOM 5379 CA PRO D 101 12.092 -21.555 -35. 464 1. 00 27.75 CATOM 5379 CA PRO D 101 12.092 -21.555 -35. 464 1. 00 27.75 C
ATOM 5380 CB PRO D 101 11.971 -20.075 - 35. 817 1. 00 26.37 CATOM 5380 CB PRO D 101 11.971 -20.075-35. 817 1. 00 26.37 C
ATOM 5381 CG PRO D 101 10.987 -19.540 -34.830 1. 00 27.66 CATOM 5381 CG PRO D 101 10.987 -19.540 -34.830 1.00 27.66 C
ATOM 5382 C PRO D 101 13.317 -21.833一 34. 599 1. 00 28.56 CATOM 5382 C PRO D 101 13.317 -21.833 1 34. 599 1. 00 28.56 C
ATOM 5383 0 PRO D 101 14.441 -21.814一 35. 093 1. 00 29.42 0ATOM 5383 0 PRO D 101 14.441 -21.814 1 35. 093 1.00 29.42 0
ATOM 5384 N SER D 102 13.099 -22.079 -33. 312 1. 00 28.30 NATOM 5384 N SER D 102 13.099 -22.079 -33. 312 1. 00 28.30 N
ATOM 5385 CA SER D 102 14.182 -22.435 -32. 408 1. 00 28.69 CATOM 5385 CA SER D 102 14.182 -22.435 -32. 408 1. 00 28.69 C
ATOM 5386 CB SER D 102 13.776 - 22.146 -30. 957 1. 00 32.24 CATOM 5386 CB SER D 102 13.776-22.146 -30. 957 1. 00 32.24 C
ATOM 5387 OG SER D 102 13.717 -20.755 -30. 699 1. 00 34.90 0ATOM 5387 OG SER D 102 13.717 -20.755 -30. 699 1.00 34.90 0
ATOM 5388 C SER D 102 14.561 -23.908 -32. 528 1. 00 28.20 CATOM 5388 C SER D 102 14.561 -23.908 -32. 528 1. 00 28.20 C
ATOM 5389 0 SER D 102 15.637 - 24.328 -32. 070 1. 00 27.94 0ATOM 5389 0 SER D 102 15.637-24.328 -32. 070 1.00 27.94 0
ATOM 5390 N ALA D 103 13.669 -24.687 - 33. 137 1. ,00 25.55 NATOM 5390 N ALA D 103 13.669 -24.687-33. 137 1., 00 25.55 N
ATOM 5391 CA ALA D 103 13.775 -26.144 -33. 125 1. ,00 25.64 CATOM 5391 CA ALA D 103 13.775 -26.144 -33. 125 1., 00 25.64 C
ATOM 5392 CB ALA 0 103 12.598 - 26.763 -33. 877 1. ,00 25.46 CATOM 5392 CB ALA 0 103 12.598-26.763 -33. 877 1., 00 25.46 C
ATOM 5393 C ALA D 103 15.081 - 26.677 - 33. 696 1. ,00 24.39 CATOM 5393 C ALA D 103 15.081-26.677-33. 696 1., 00 24.39 C
ATOM 5394 0 ALA D 103 15.682 -26.091 -34. 591 1. ,00 22.69 0ATOM 5394 0 ALA D 103 15.682 -26.091 -34. 591 1., 00 22.69 0
ATOM 5395 N ARG D 104 15.503 -27.812 -33. 159 1. .00 26.62 NATOM 5395 N ARG D 104 15.503 -27.812 -33. 159 1. .00 26.62 N
ATOM 5396 CA ARG D 104 16.662 -28.528 -33. 657 1. .00 25.24 CATOM 5396 CA ARG D 104 16.662 -28.528 -33. 657 1. .00 25.24 C
ATOM 5397 CB ARG D 104 17.164 - 29.505 -32. 589 1. .00 25.66 CATOM 5397 CB ARG D 104 17.164-29.505 -32. 589 1. .00 25.66 C
ATOM 5398 CG ARG D 104 18.440 -30.257 -32.965 1. ,00 29.66 CATOM 5398 CG ARG D 104 18.440 -30.257 -32.965 1., 00 29.66 C
ATOM 5399 CD ARG D 104 18.934 -31.110 -31. 804 1. .00 30.06 CATOM 5399 CD ARG D 104 18.934 -31.110 -31. 804 1. .00 30.06 C
ATOM 5400 NE ARG D 104 17.899 - 32.035 -31. 357 1. .00 32.71 NATOM 5400 NE ARG D 104 17.899-32.035 -31. 357 1. .00 32.71 N
ATOM 5401 CZ ARG D 104 18.124 -33.101 - 30. 599 1. .00 31.61 CATOM 5401 CZ ARG D 104 18.124 -33.101-30. 599 1. .00 31.61 C
ATOM 5402 NH1 ARG D 104 19.357 - 33.381 -30. 197 1, .00 32.34 NATOM 5402 NH1 ARG D 104 19.357-33.381 -30. 197 1, .00 32.34 N
ATOM 5403 NH2 ARG D 104 17.114 -33.887 -30. 247 1, .00 30.70 NATOM 5403 NH2 ARG D 104 17.114 -33.887 -30. 247 1, .00 30.70 N
ATOM 5404 C ARG D 104 16.237 - 29.283 - 34. 907 1, .00 24.52 CATOM 5404 C ARG D 104 16.237-29.283-34. 907 1, .00 24.52 C
ATOM 5405 0 ARG D 104 15.069 -29.624 - 35. 067 1, .00 24.83 0ATOM 5405 0 ARG D 104 15.069 -29.624-35. 067 1, .00 24.83 0
ATOM 5406 N ILE D 105 17.185 -29.533 -35. 798 1, .00 24.25 NATOM 5406 N ILE D 105 17.185 -29.533 -35. 798 1, .00 24.25 N
ATOM 5407 CA ILE D 105 16.893 -30.268 -37. 018 1 .00 23.80 CATOM 5407 CA ILE D 105 16.893 -30.268 -37. 018 1 .00 23.80 C
ATOM 5408 CB ILE D 105 17.206 -29.413 -38. 276 1 .00 26.75 CATOM 5408 CB ILE D 105 17.206 -29.413 -38. 276 1 .00 26.75 C
ATOM 5409 CG2 ILE D 105 16.876 -30.196 -39. 538 1, .00 26.07 CATOM 5409 CG2 ILE D 105 16.876 -30.196 -39. 538 1, .00 26.07 C
ATOM 5410 CG1 ILE D 105 16.409 - 28.107 -38. ,241 1 • 00 28.18 CATOM 5410 CG1 ILE D 105 16.409-28.107 -38., 241 1 • 00 28.18 C
ATOM 5411 GD1 ILE D 105 16.611一 27.226 -39. 470 1 • 00 29.80 C ATOM 5412 C ILE D 105 17.764 -31.520 - 37.050 1.00 22.69 CATOM 5411 GD1 ILE D 105 16.611 One 27.226 -39. 470 1 • 00 29.80 C ATOM 5412 C ILE D 105 17.764 -31.520-37.050 1.00 22.69 C
ATOM 5413 0 ILE D 105 18.988 -31.423 - 36. 987 1. 00 20.27 0ATOM 5413 0 ILE D 105 18.988 -31.423-36. 987 1.00 20.27 0
ATOM 5414 N SER D 106 17.119 -32.684 -37. 136 1. 00 22.61 NATOM 5414 N SER D 106 17.119 -32.684 -37. 136 1. 00 22.61 N
ATOM 5415 GA SER D 106 17.798 -33.966 - 37. 299 1. 00 22.64 CATOM 5415 GA SER D 106 17.798 -33.966-37. 299 1. 00 22.64 C
ATOM 5416 CB SER D 106 17.504 - 34.898 -36. 121 1. 00 24.41 CATOM 5416 CB SER D 106 17.504-34.898 -36. 121 1. 00 24.41 C
ATOM 5417 OG SER D 106 18.355 -34.623 -35. 024 1. 00 28.23 0ATOM 5417 OG SER D 106 18.355 -34.623 -35. 024 1. 00 28.23 0
ATOM 5418 C SER D 106 17.326 -34.641 -38. 566 1. 00 22.74 CATOM 5418 C SER D 106 17.326 -34.641 -38. 566 1. 00 22.74 C
ATOM 5419 0 SER D 106 16.271一 35.271 -38. 584 1. 00 23.29 0ATOM 5419 0 SER D 106 16.271 One 35.271 -38. 584 1. 00 23.29 0
ATOM 5420 N VAL D 107 18.110 -34.518 - 39. 626 1. 00 22.49 NATOM 5420 N VAL D 107 18.110 -34.518-39. 626 1. 00 22.49 N
ATOM 5421 CA VAL D 107 17.810 -35.221 -40. 864 1. 00 23.78 CATOM 5421 CA VAL D 107 17.810 -35.221 -40. 864 1. 00 23.78 C
ATOM 5422 CB VAL D 107 18.604 -34.620 -42. 020 1. 00 24.74 CATOM 5422 CB VAL D 107 18.604 -34.620 -42. 020 1. 00 24.74 C
ATOM 5423 . GG1 VAL ひ 107 17.768 -33.609 -42. 743. 1. 00 25.57 CATOM 5423 .GG1 VAL H 107 17.768 -33.609 -42. 743. 1. 00 25.57 C
ATOM 5424 CG2 VAL D 107 19.853 - 33.944 -41. 461 1. 00 28.48 CATOM 5424 CG2 VAL D 107 19.853-33.944 -41. 461 1. 00 28.48 C
ATOM 5425 C VAL D 107 18.153 -36.704 -40. 746 1. 00 22.07 CATOM 5425 C VAL D 107 18.153 -36.704 -40. 746 1. 00 22.07 C
ATOM 5426 0 VAL D 107 19.218 - 37.059 -40. 260 1. ,00 18.50 0ATOM 5426 0 VAL D 107 19.218-37.059 -40.260 1., 00 18.50 0
ATOM 5427 N VAL D 108 17.233 - 37.553 -41. 194 1. 00 24.18 NATOM 5427 N VAL D 108 17.233-37.553 -41. 194 1. 00 24.18 N
ATOM 5428 CA VAL D 108 17.437 -38.992 -41. 230 1. ,00 25.92 CATOM 5428 CA VAL D 108 17.437 -38.992 -41.230 1., 00 25.92 C
ATOM 5429 CB VAL D 108 16.447 -39.714 -40. 300 1. ,00 24.71 CATOM 5429 CB VAL D 108 16.447 -39.714 -40. 300 1., 00 24.71 C
ATOM 5430 C61 VAL D 108 15.043 -39.231 -40. 573 1. .00 28.67 CATOM 5430 C61 VAL D 108 15.043 -39.231 -40. 573 1. .00 28.67 C
ATOM 5431 CG2 VAL D 108 16.500 -41 · 211 -40. 542 1. ,00 26.25 CATOM 5431 CG2 VAL D 108 16.500 -41 · 211 -40. 542 1., 00 26.25 C
ATOM 5432 C VAL D 108 17.241 -39.523 -42. 647 1. ,00 27.70 CATOM 5432 C VAL D 108 17.241 -39.523 -42. 647 1., 00 27.70 C
ATOM 5433 0 VAL D 108 16.314 -39.118 - 43. 342 1. .00 26.25 0ATOM 5433 0 VAL D 108 16.314 -39.118-43. 342 1. .00 26.25 0
ATOM 5434 N GLY D 109 18.118 -40.434 -43.067 1. ,00 30.55 NATOM 5434 N GLY D 109 18.118 -40.434 -43.067 1., 00 30.55 N
ATOM 5435 CA 6LY D 109 17.963 -41.076 -44. 362 1. .00 32.00 CATOM 5435 CA 6LY D 109 17.963 -41.076 -44. 362 1. .00 32.00 C
ATOM 5436 C GLY D 109 17.649 -42.569 -44. 315 1. ,00 34.16 CATOM 5436 C GLY D 109 17.649 -42.569 -44. 315 1., 00 34.16 C
ATOM 5437 0 GLY D 109 17.618 -43.194 - 43. 252 1. .00 33.24 0ATOM 5437 0 GLY D 109 17.618 -43.194-43. 252 1. .00 33.24 0
ATOM 5438 N MET D 110 17.399 -43.138 -45. 487 1. .00 34.79 NATOM 5438 N MET D 110 17.399 -43.138 -45. 487 1. .00 34.79 N
ATOM 5439 CA MET D 110 17.246 -44.574 -45. 622 1, .00 36.81 CATOM 5439 CA MET D 110 17.246 -44.574 -45. 622 1, .00 36.81 C
ATOM 5440 CB MET D 110 15.889 -44.895 - 46. 260 1. .00 38.53 CATOM 5440 CB MET D 110 15.889 -44.895-46. 260 1. .00 38.53 C
ATOM 5441 CG MET D 110 14.676 -44.423 -45. 459 1, .00 42.60 CATOM 5441 CG MET D 110 14.676 -44.423 -45. 459 1, .00 42.60 C
ATOM 5442 SD MET D 110 14.473 - 45.285 -43. 872 1, .00 46.27 SATOM 5442 SD MET D 110 14.473-45.285 -43. 872 1, .00 46.27 S
ATOM 5443 CE MET D 110 14.623 -43.929 -42. 737 1, .00 46.56 CATOM 5443 CE MET D 110 14.623 -43.929 -42. 737 1, .00 46.56 C
ATOM 5444 C MET D 110 18.372 -45.099 -46. 513 1, .00 37.45 CATOM 5444 C MET D 110 18.372 -45.099 -46. 513 1, .00 37.45 C
ATOM 5445 0 MET D 110 18.472 -44.701 -47. 669 1, .00 35.96 0ATOM 5445 0 MET D 110 18.472 -44.701 -47. 669 1, .00 35.96 0
ATOM 5446 N TY D 111 19.225 - 45.972 -45. ,981 1 .00 38.17 NATOM 5446 N TY D 111 19.225-45.972 -45., 981 1 .00 38.17 N
ATOM 5447 CA TYR D 111 20.155 -46.711 -46. 830 1 .00 40.58 C ATOM 5448 CB TYR D 111 21 · 201 - 47.469 -46.001 1.0042.26 CATOM 5447 CA TYR D 111 20.155 -46.711 -46. 830 1 .00 40.58 C ATOM 5448 CB TYR D 111 21 201-47.469 -46.001 1.0042.26 C
ATOM 5449 CG TYR D 111 22.324 - 46. 626 -45. 423 1.0045.69 CATOM 5449 CG TYR D 111 22.324-46. 626 -45. 423 1.0045.69 C
ATOM 5450 CD1 TYR D 111 23.032 - 45. 722 -46. 212 1.0046.50 CATOM 5450 CD1 TYR D 111 23.032-45. 722 -46. 212 1.0046.50 C
ATOM 5451 CE1 TYR D 111 24.068 -44. 951 -45. 671 1.0046.98 CATOM 5451 CE1 TYR D 111 24.068 -44. 951 -45. 671 1.0046.98 C
ATOM 5452 CD2 TYR D 111 22.686 -46. 740 -44. 079 1.0046.45 CATOM 5452 CD2 TYR D 111 22.686 -46. 740 -44. 079 1.0046.45 C
ATOM 5453 CE2 TYR D" 111 23.716 -45. 980 -43. 535 1.0043.72 CATOM 5453 CE2 TYR D "111 23.716 -45. 980 -43. 535 1.0043.72 C
ATOM 5454 CZ TYR D 111 24.400 -45. 089 -44. 331 1.0045.97 CATOM 5454 CZ TYR D 111 24.400 -45. 089 -44. 331 1.0045.97 C
ATOM 5455 OH TYR D 111 25.406 -44. 327 - 43. 780 1.0046.18 0ATOM 5455 OH TYR D 111 25.406 -44. 327-43. 780 1.0046.18 0
ATOM 5456 C TYR D 111 19.311 - 47. 716 -47. 592 1.0042.34 CATOM 5456 C TYR D 111 19.311-47. 716 -47. 592 1.0042.34 C
ATOM 5457 0 TYR D 111 18.519 -48. 435 -46. 991 1.00.42.92 0ATOM 5457 0 TYR D 111 18.519 -48. 435 -46. 991 1.00.42.92 0
ATOM 5458 N ARG D 112 19.463 - 47. 766 -48. 910 1.0044.37 NATOM 5458 N ARG D 112 19.463-47. 766 -48. 910 1.0044.37 N
ATOM 5459 CA ARG D 112 18.720 -48. 736 -49. 703 1.0048.85 CATOM 5459 CA ARG D 112 18.720 -48. 736 -49. 703 1.0048.85 C
ATOM 5460 CB ARG D 112 17.678 - 48: 021 -50. 569 1.0051.35 CATOM 5460 CB ARG D 112 17.678-48: 021 -50. 569 1.0051.35 C
ATOM 5461 CG ARG D 112 16.589 -47. 322 -49. 762 1.00 54.43 CATOM 5461 CG ARG D 112 16.589 -47. 322 -49. 762 1.00 54.43 C
ATOM 5462 CD ARG D 112 15.505 -46. 756 -50. 661 1.0057.21 CATOM 5462 CD ARG D 112 15.505 -46. 756 -50. 661 1.0057.21 C
ATOM 5463 NE ARG D 112 14.633 -45. 820 -49. 954 1.00 58.70 NATOM 5463 NE ARG D 112 14.633 -45. 820 -49. 954 1.00 58.70 N
ATOM 5464 CZ ARG D 112 14.837 -44. 506 -49. 895 1.00 60.17 CATOM 5464 CZ ARG D 112 14.837 -44. 506 -49. 895 1.00 60.17 C
ATOM 5465 NH1 ARG D 112 15.887 -43. 964 - 50. 501 1.00 60.48 NATOM 5465 NH1 ARG D 112 15.887 -43. 964-50. 501 1.00 60.48 N
ATOM 5466 NH2 ARG D 112 13.987 -43. 730 -49. 235 1.00 62.25 NATOM 5466 NH2 ARG D 112 13.987 -43. 730 -49. 235 1.00 62.25 N
ATOM 5467 C ARG D 112 19.632 -49. 588 -50. 580 1.0049.36 CATOM 5467 C ARG D 112 19.632 -49. 588 -50. 580 1.0049.36 C
ATOM 5468 0 ARG D 112 19.930 -49. 231 -51. 716 1.0049.85 0ATOM 5468 0 ARG D 112 19.930 -49. 231 -51. 716 1.0049.85 0
ATOM 5469 N ASN D 113 20.075 -50. 718 -50. 043 1.0049.82 NATOM 5469 N ASN D 113 20.075 -50. 718 -50. 043 1.0049.82 N
ATOM 5470 CA ASN D 113 20.912 -51. 639 -50. 796 1.00 50.43 CATOM 5470 CA ASN D 113 20.912 -51. 639 -50. 796 1.00 50.43 C
ATOM 5471 CB ASN D 113 22.302 - 51. 734 -50. 162 1.0051.12 CATOM 5471 CB ASN D 113 22.302-51. 734 -50. 162 1.0051.12 C
ATOM 5472 CG ASN D 113 23.242 -52. 639 - 50. 946 1.00 53.75 CATOM 5472 CG ASN D 113 23.242 -52. 639-50. 946 1.00 53.75 C
ATOM 5473 0D1 ASN D 113 22.839 -53. 295 -51. 914 1.00 53.40 0ATOM 5473 0D1 ASN D 113 22.839 -53. 295 -51. 914 1.00 53.40 0
ATOM 5474 ND2 ASN D 113 24.506 -52. 679 -50. 530 1 · 00 53.75 NATOM 5474 ND2 ASN D 113 24.506 -52.679 -50.530 1 00 53.75 N
ATOM 5475 C ASN D 113 20.279 - 53. 021 -50. 844 1.00 50.60 CATOM 5475 C ASN D 113 20.279-53. 021 -50. 844 1.00 50.60 C
ATOM 5476 0 ASN D 113 19.772 - 53. 519 -49. 839 1.0049.48 0ATOM 5476 0 ASN D 113 19.772-53. 519 -49. 839 1.0049.48 0
ATOM 5477 N GLU D 114 20.311 - 53. 637 -52. 020 1.0051.84 NATOM 5477 N GLU D 114 20.311-53. 637 -52. 020 1.0051.84 N
ATOM 5478 CA GLU D 114 19.885 -55. 020 -52. 163 1.0053.79 CATOM 5478 CA GLU D 114 19.885 -55. 020 -52. 163 1.0053.79 C
ATOM 5479 CB GLU D 114 20.132 -55. 499 -53. 595 1.00 56.21 CATOM 5479 CB GLU D 114 20.132 -55. 499 -53. 595 1.00 56.21 C
ATOM 5480 CG GLU D 114 18.938 -55. 329 - 54. 523 1.00 60.85 CATOM 5480 CG GLU D 114 18.938 -55. 329-54. 523 1.00 60.85 C
ATOM 5481 CD GLU D 114 17.757 -56. 206 -54. 126 1.00 63.12 CATOM 5481 CD GLU D 114 17.757 -56. 206 -54. 126 1.00 63.12 C
ATOM 5482 0E1 GLU D 114 17.309 - 57. 025 -54. 963 1.00 62.50 0ATOM 5482 0E1 GLU D 114 17.309-57. 025 -54. 963 1.00 62.50 0
ATOM 5483 0E2 GLU D 114 17.278一 56, 076一 52. 976 1.00 64.41 0 ATOM 5484 C GLU D 114 20.610 - 55.942 -51.181 1.00 53.21 CATOM 5483 0E2 GLU D 114 17.278 1 56, 076 1 52. 976 1.00 64.41 0 ATOM 5484 C GLU D 114 20.610-55.942 -51.181 1.00 53.21 C
ATOM 5485 0 6LU D 114 20.043 -56.928 -50. 715 1. 00 52.95 0ATOM 5485 0 6LU D 114 20.043 -56.928 -50. 715 1.00 52.95 0
ATOM 5486 N GLU D 115 21.859 -55.613 -50. 863 1. 00 52.61 NATOM 5486 N GLU D 115 21.859 -55.613 -50. 863 1. 00 52.61 N
ATOM 5487 CA GLU D 115 22.693一 56.491 -50. 049 1. 00 53.27 CATOM 5487 CA GLU D 115 22.693 1 56.491 -50. 049 1. 00 53.27 C
ATOM 5488 CB GLU D 115 24.153 -56.041 - 50. 093 1. 00 55.13 CATOM 5488 CB GLU D 115 24.153 -56.041-50. 093 1. 00 55.13 C
ATOM 5489 CG GLU D 115 24.879 -56.403 -51. 374 1. 00 58.23 CATOM 5489 CG GLU D 115 24.879 -56.403 -51. 374 1. 00 58.23 C
ATOM 5490 CD GLU D 115 24.412 -55.582 -52. 555 1. 00 60.85 CATOM 5490 CD GLU D 115 24.412 -55.582 -52. 555 1. 00 60.85 C
ATOM 5491 0E1 GLU D 115 25.059 -54.553 -52. 848 1. 00 62.53 0ATOM 5491 0E1 GLU D 115 25.059 -54.553 -52. 848 1. 00 62.53 0
ATOM 5492 0E2 GLU D 115 23.402 -55.962 -53. 190 1. 00 61.37 0ATOM 5492 0E2 GLU D 115 23.402 -55.962 -53. 190 1. 00 61.37 0
ATOM 5493 C GLU D 115 22.252 -56.580 - 48. 594 1. 00 52.68 CATOM 5493 C GLU D 115 22.252 -56.580-48. 594 1. 00 52.68 C
ATOM 5494 0 GLU D 115 22.578 -57.550 -47. 909 1. 00 51.40 0ATOM 5494 0 GLU D 115 22.578 -57.550 -47. 909 1.00 51.40 0
ATOM 5495 .N THR D 116 21.527 -55.570 - 48. 119 1. 00 51.10 NATOM 5495 .N THR D 116 21.527 -55.570-48. 119 1. 00 51.10 N
ATOM 5496 CA THR D 116 -55.534 -46. 718 1. 00 50.35 CATOM 5496 CA THR D 116 -55.534 -46. 718 1. 00 50.35 C
ATOM 5497 CB THR D 116 -54.105 -46. 140 1. 00 49.97 CATOM 5497 CB THR D 116 -54.105 -46. 140 1. 00 49.97 C
ATOM 5498 0G1 THR D 116 20.260 -53.260 -46. 824 1. 00 48.47 0ATOM 5498 0G1 THR D 116 20.260 -53.260 -46. 824 1. 00 48.47 0
ATOM 5499 GG2 THR D 116 22.603 - 53.539 -46. 296 1. 00 47.77 CATOM 5499 GG2 THR D 116 22.603-53.539 -46. 296 1. 00 47.77 C
ATOM 5500 C THR D 116 19.704 -56.064 -46. 537 1. 00 50.75 CATOM 5500 C THR D 116 19.704 -56.064 -46. 537 1. 00 50.75 C
ATOM 5501 0 THR D 116 19.011 -56.346 -47. 509 1. 00 51.19 0ATOM 5501 0 THR D 116 19.011 -56.346 -47. 509 1.00 51.19 0
ATOM 5502 N LEU D 117 19.286 - 56.199 - 45. 284 1. ,00 52.40 NATOM 5502 N LEU D 117 19.286-56.199-45. 284 1., 00 52.40 N
ATOM 5503 CA LEU D 117 18.031 -56.865 -44. 954 1. .00 54.07 CATOM 5503 CA LEU D 117 18.031 -56.865 -44. 954 1. .00 54.07 C
ATOM 5504 CB LEU D 117 18.011 - 57.225 -43. 465 1. 00 53.99 CATOM 5504 CB LEU D 117 18.011-57.225 -43. 465 1. 00 53.99 C
ATOM 5505 C6 LEU D 117 16.726 -57.850 - 42. 917 1. ,00 55.31 CATOM 5505 C6 LEU D 117 16.726 -57.850-42. 917 1., 00 55.31 C
ATOM 5506 CD1 LEU D 117 16.345 -59.072 -43.740 1. ,00 53.98 CATOM 5506 CD1 LEU D 117 16.345 -59.072 -43.740 1., 00 53.98 C
ATOM 5507 CD2 LEU D 117 16.934 -58.225 -41. 462 1. .00 54.10 CATOM 5507 CD2 LEU D 117 16.934 -58.225 -41. 462 1. .00 54.10 C
ATOM 5508 C LEU D 117 16.818 - 56.002 -45. 290 1. .00 54.61 GATOM 5508 C LEU D 117 16.818-56.002 -45. 290 1. .00 54.61 G
ATOM 5509 0 LEU D 117 15.847 -56.470 -45. 888 1, .00 55.58 0ATOM 5509 0 LEU D 117 15.847 -56.470 -45. 888 1, .00 55.58 0
ATOM 5510 N GLU D 118 16.876 -54.740 -44. 893 1. .00 54.69 . NATOM 5510 N GLU D 118 16.876 -54.740 -44. 893 1. .00 54.69. N
ATOM 5511 CA GLU D 118 15.798 -53.805 -45. 169 1. .00 54.28 CATOM 5511 CA GLU D 118 15.798 -53.805 -45. 169 1. .00 54.28 C
ATOM 5512 CB GLU D 118 14.909 -53.643 -43. 935 1, .00 56.41 CATOM 5512 CB GLU D 118 14.909 -53.643 -43. 935 1, .00 56.41 C
ATO 5513 CG GLU D 118 14.286 - 54.935 -43. 431 1, .00 61.32 CATO 5513 CG GLU D 118 14.286-54.935 -43. 431 1, .00 61.32 C
ATOM 5514 CD GLU D 118 13.770 -54.820 -42. 003 1 .00 63.28 CATOM 5514 CD GLU D 118 13.770 -54.820 -42. 003 1 .00 63.28 C
ATOM 5515 0E1 GLU D 118 14.419 -54.134 -41. 182 1, .00 62.64 0ATOM 5515 0E1 GLU D 118 14.419 -54.134 -41. 182 1, .00 62.64 0
ATOM 5516 0E2 GLU D 118 12.712 -55.416 - 41. 703 1 .00 65.46 0ATOM 5516 0E2 GLU D 118 12.712 -55.416-41. 703 1 .00 65.46 0
ATOM 5517 C GLU D 118 16.425 -52.469 -45. 520 1 • 00 52.04 CATOM 5517 C GLU D 118 16.425 -52.469 -45. 520 1 • 00 52.04 C
ATOM 5518 0 GLU D 118 17.646 -52.319 -45. 483 1 .00 52.20 0ATOM 5518 0 GLU D 118 17.646 -52.319 -45. 483 1 .00 52.20 0
ATOM 5519 N PRO D 119 15.598 -51.479一 45. 875 1 ■ 00 49.93 N ATOM 5520 CD PRO D 119 14.279 -51.575 -46.525 1.00 49.84 CATOM 5519 N PRO D 119 15.598 -51.479 1 45. 875 1 ■ 00 49.93 N ATOM 5520 CD PRO D 119 14.279 -51.575 -46.525 1.00 49.84 C
ATOM 5521 CA PRO D 119 16.054 -50.092 -45.756 1. 00 46.92 CATOM 5521 CA PRO D 119 16.054 -50.092 -45.756 1. 00 46.92 C
ATOM 5522 CB PRO D 119 14.856 -49.279 -46.242 1. 00 47.69 CATOM 5522 CB PRO D 119 14.856 -49.279 -46.242 1. 00 47.69 C
ATOM 5523 CG PRO D 119 14.114 -50.216 -47.145 1. 00 48.77 CATOM 5523 CG PRO D 119 14.114 -50.216 -47.145 1. 00 48.77 C
ATOM 5524 C PRO D 119 16.397 -49.792 -44.299 1. 00 44.44 CATOM 5524 C PRO D 119 16.397 -49.792 -44.299 1.00 44.44 C
ATOM 5525 0 PRO D 119 15.583 -50.011 -43.401 1. 00 45.45 0ATOM 5525 0 PRO D 119 15.583 -50.011 -43.401 1.00 45.45 0
ATOM 5526 N VAL D 120 17.603 -49.305 -44.056 1. 00 40.16 NATOM 5526 N VAL D 120 17.603 -49.305 -44.056 1. 00 40.16 N
ATOM 5527 CA VAL D 120 17.960 -48.890 -42.712 1. 00 40.29 CATOM 5527 CA VAL D 120 17.960 -48.890 -42.712 1. 00 40.29 C
ATOM 5528 CB VAL D 120 19.322 -49.487 -42.281 1. 00 40.18 GATOM 5528 CB VAL D 120 19.322 -49.487 -42.281 1.00 40.18 G
ATOM 5529 CG1 VAL D 120 19.182 -50.991 -42.057 1. 00 41.53 CATOM 5529 CG1 VAL D 120 19.182 -50.991 -42.057 1.00 41.53 C
ATOM 5530 CG2 VAL D 120 20.365 -49.223 - 43.350 1. 00 40.85 CATOM 5530 CG2 VAL D 120 20.365 -49.223-43.350 1. 00 40.85 C
ATOM 5531 C VAL D 120 18.002 -47.368一 42.586 1. 00 39.21 CATOM 5531 C VAL D 120 18.002 -47.368 One 42.586 1. 00 39.21 C
ATOM 5532 0 VAL D 120 18.651 -46.675 -43.372 1. 00 38.73 0ATOM 5532 0 VAL D 120 18.651 -46.675 -43.372 1. 00 38.73 0
ATOM 5533 N PRO D 121 17.289 -46.829 -41.588 1. 00 37.36 NATOM 5533 N PRO D 121 17.289 -46.829 -41.588 1. 00 37.36 N
ATOM 5534 CD PRO D 121 16.397 - 47.590 -40.696 1. 00 35.27 CATOM 5534 CD PRO D 121 16.397-47.590 -40.696 1. 00 35.27 C
ATOM 5535 CA PRO D 121 17.352 - 45.406 1. 00 36.27 CATOM 5535 CA PRO D 121 17.352-45.406 1. 00 36.27 C
ATOM 5536 CB PRO D 121 16.245 -45.248 -40.194 1. ,00 36.27 CATOM 5536 CB PRO D 121 16.245 -45.248 -40.194 1., 00 36.27 C
ATOM 5537 CG PRO D 121 16.102 -46.620 -39.589 1. 00 36.51 CATOM 5537 CG PRO D 121 16.102 -46.620 -39.589 1. 00 36.51 C
ATOM 5538 C PRO D 121 18.725 -45.025 -40.673 1. ,00 34.96 CATOM 5538 C PRO D 121 18.725 -45.025 -40.673 1., 00 34.96 C
ATOM 5539 0 PRO D 121 19.398 -45.849 - 40.045 1. ,00 34.34 0ATOM 5539 0 PRO D 121 19.398 -45.849-40.045 1., 00 34.34 0
ATOM 5540 TYR D 122 19.140 -43.781 -40.898 1. ,00 33.83 NATOM 5540 TYR D 122 19.140 -43.781 -40.898 1., 00 33.83 N
ATOM 5541 CA TYR D 122 20.377 -43.279 -40.297 1. .00 32.12 CATOM 5541 CA TYR D 122 20.377 -43.279 -40.297 1. .00 32.12 C
ATOM 5542 CB TYR D 122 21.586 -43.619 -41'.179 1. ,00 30.04 CATOM 5542 CB TYR D 122 21.586 -43.619 -41'.179 1., 00 30.04 C
ATOM 5543 CG TYR D 122 21.553 -42.995 - 42.559 1, .00 28.53 cATOM 5543 CG TYR D 122 21.553 -42.995-42.559 1, .00 28.53 c
ATOM 5544 CD1 TYR D 122 22.092 -41.734 -42.790 1. .00 29.52 cATOM 5544 CD1 TYR D 122 22.092 -41.734 -42.790 1. .00 29.52 c
ATOM 5545 CE1 TYR D 122 22.081 -44.057 1, .00 28.26 cATOM 5545 CE1 TYR D 122 22.081 -44.057 1, .00 28.26 c
ATOM 5546 CD2 TYR D 122 21.001 -43.675 -43.632 1, .00 26.75 cATOM 5546 CD2 TYR D 122 21.001 -43.675 -43.632 1, .00 26.75 c
ATOM 5547 CE2 TYR D 122 20.984 -43.124 -44.897 1, .00 27.64 cATOM 5547 CE2 TYR D 122 20.984 -43.124 -44.897 1, .00 27.64 c
ATOM 5548 CZ TYR D 122 21.526 -41.875 - 45.106 1, .00 28.29 cATOM 5548 CZ TYR D 122 21.526 -41.875-45.106 1, .00 28.29 c
ATOM 5549 OH TYR D 122 21.515 -41.334 -46.369 1, .00 25.82 0ATOM 5549 OH TYR D 122 21.515 -41.334 -46.369 1, .00 25.82 0
ATOM 5550 C TYR D 122 20.334 -41.775 -40.069 1 .00 31.20 cATOM 5550 C TYR D 122 20.334 -41.775 -40.069 1 .00 31.20 c
ATOM 5551 0 TYR D 122 19.688 - 41.048 -40.817 1 • 00 0ATOM 5551 0 TYR D 122 19.688-41.048 -40.817 1 • 00 0
ATOM 5552 N PHE D 123 21.030 -41.325 - 39.030 1, .00 30.73 NATOM 5552 N PHE D 123 21.030 -41.325-39.030 1, .00 30.73 N
ATOM 5553 CA PHE D 123 21■ 246 - 39.902 - 38.788 1 ■ 00 32.19 cATOM 5553 CA PHE D 123 21 ■ 246-39.902-38.788 1 ■ 00 32.19 c
ATOM 5554 CB PHE D 123 21.744 - 39.667 -37.359 1 .00 31.58 cATOM 5554 CB PHE D 123 21.744-39.667 -37.359 1 .00 31.58 c
ATOM 5555 CG PHE D 123 20.703 - 39.893 - 36.304 1 .00 31.58 c ATOM 5556 CD1 PHE D 123 19.648 -39.010 -36.155 1.00 29.83 GATOM 5555 CG PHE D 123 20.703-39.893-36.304 1 .00 31.58 c ATOM 5556 CD1 PHE D 123 19.648 -39.010 -36.155 1.00 29.83 G
ATOM 5557 CD2 PHE D 123 20.797 -40.971 - 35.442 1. 00 29.33 CATOM 5557 CD2 PHE D 123 20.797 -40.971-35.442 1. 00 29.33 C
ATOM 5558 CE1 PHE D 123 18.709 -39.192 -35.169 1. 00 30.67 CATOM 5558 CE1 PHE D 123 18.709 -39.192 -35.169 1. 00 30.67 C
ATOM 5559 CE2 PHE D 123 19.858 -41.162 -34.449 1. 00 31.80 CATOM 5559 CE2 PHE D 123 19.858 -41.162 -34.449 1. 00 31.80 C
ATOM 5560 CZ PHE D 123 18.811 -40.272 -34.310 1. 00 31.70 CATOM 5560 CZ PHE D 123 18.811 -40.272 -34.310 1. 00 31.70 C
ATOM 5561 C PHE D 123 22.287 - 39.353 -39. 754 1. 00 33.49 CATOM 5561 C PHE D 123 22.287-39.353 -39. 754 1. 00 33.49 C
ATOM 5562 0 PHE D 123 23.330. - 39.979 -39. 984 1. 00 32.79 0ATOM 5562 0 PHE D 123 23.330.- 39.979 -39. 984 1. 00 32.79 0
ATOM 5563 N GLN D 124 22.019 -38.179 -40. 314 1. 00 31.74 NATOM 5563 N GLN D 124 22.019 -38.179 -40. 314 1. 00 31.74 N
ATOM 5564 CA GLN D 124 23.043 -37.510 -41. 099 1. 00 31.81 CATOM 5564 CA GLN D 124 23.043 -37.510 -41. 099 1.00 31.81 C
ATOM 5565 CB GLN D 124 22.487 - 36.255 - 41. 772 1. 00 31.55 CATOM 5565 CB GLN D 124 22.487-36.255-41. 772 1. 00 31.55 C
ATOM 5566 C6 GLN D 124 23.421 - 35.683 -42. 806 1. 00 28.63 CATOM 5566 C6 GLN D 124 23.421-35.683 -42. 806 1. 00 28.63 C
ATOM 5567 CD GLN D 124 23.761 -36.695 -43. 878 1. 00 27.42 CATOM 5567 CD GLN D 124 23.761 -36.695 -43. 878 1. 00 27.42 C
ATOM 5568 0E1 GLN D 124 22.896 - 37.442 - 44. 334 1. 00 24.20 0ATOM 5568 0E1 GLN D 124 22.896-37.442-44. 334 1. 00 24.20 0
ATOM 5569 NE2 GLN D 124 25.028 - 36.729 -44. 284 1. 00 26.91 NATOM 5569 NE2 GLN D 124 25.028-36.729 -44. 284 1. 00 26.91 N
ATOM 5570 C GLN D 124 24.172 -37.132 -40. 160 1. 00 30.81 CATOM 5570 C GLN D 124 24.172 -37.132 -40. 160 1. 00 30.81 C
ATOM 5571 0 GLN D 124 25.339 -37.277 -40. 499 1. 00 31.37 0ATOM 5571 0 GLN D 124 25.339 -37.277 -40. 499 1. 00 31.37 0
ATOM 5572 N LYS D 125 23.813 -36.636 - 38. 978 1. 00 31.26 NATOM 5572 N LYS D 125 23.813 -36.636-38. 978 1. 00 31.26 N
ATOM 5573 CA LYS D 125 24.761 -36.505 -37. 877 1. 00 30.83 CATOM 5573 CA LYS D 125 24.761 -36.505 -37. 877 1. 00 30.83 C
ATOM 5574 CB LYS D 125 25.118 -35.040 -37. 622 1. .00 32.81 CATOM 5574 CB LYS D 125 25.118 -35.040 -37. 622 1. .00 32.81 C
ATOM 5575 CG LYS D 125 26.034 -34.877 - 36. 410 1. ,00 33.84 CATOM 5575 CG LYS D 125 26.034 -34.877-36. 410 1., 00 33.84 C
ATOM 5576 CD LYS D 125 26.521 -33.459 -36. 212 1. ,00 35.58 CATOM 5576 CD LYS D 125 26.521 -33.459 -36. 212 1., 00 35.58 C
ATOM 5577 CE LYS D 125 27.556 -33.418 -35. 092 1. .00 38.81 CATOM 5577 CE LYS D 125 27.556 -33.418 -35. 092 1. .00 38.81 C
ATOM 5578 NZ LYS D 125 28.264 -32.110 -35.000 1. .00 40.99 NATOM 5578 NZ LYS D 125 28.264 -32.110 -35.000 1. .00 40.99 N
ATOM 5579 C LYS D 125 24.173 -37.097 - 36. 605 1. .00 30.70 CATOM 5579 C LYS D 125 24.173 -37.097-36. 605 1. .00 30.70 C
ATOM 5580 0 LYS D 125 23.003 -36.909 -36. 306 1. .00 30.34 0ATOM 5580 0 LYS D 125 23.003 -36.909 -36. 306 1. .00 30.34 0
ATOM 5581 N LEU D 126 24.994 -37.808 - 35. 848 1, .00 33.29 NATOM 5581 N LEU D 126 24.994 -37.808-35. 848 1, .00 33.29 N
ATOM 5582 CA LEU D 126 24.513 -38.510 - 34. 666 1, .00 33.47 CATOM 5582 CA LEU D 126 24.513 -38.510-34. 666 1, .00 33.47 C
ATOM 5583 CB LEU D 126 25.517 - 39.590 - 34. 252 1, .00 34.71 CATOM 5583 CB LEU D 126 25.517-39.590-34. 252 1, .00 34.71 C
ATOM 5584 CG LEU D 126 25.040 -40.817 -33. 459 1 .00 37.46 CATOM 5584 CG LEU D 126 25.040 -40.817 -33. 459 1 .00 37.46 C
ATOM 5585 CD1 LEU D 126 26.260 -41.461 -32. 822 1, .00 38.41 GATOM 5585 CD1 LEU D 126 26.260 -41.461 -32. 822 1, .00 38.41 G
ATOM 5586 CD2 LEU D 126 24.031 -40.445 -32. 385 1, .00 35.66 CATOM 5586 CD2 LEU D 126 24.031 -40.445 -32. 385 1, .00 35.66 C
ATOM 5587 C LEU D 126 24.351 -37.501 - 33. 542 1, .00 32.68 CATOM 5587 C LEU D 126 24.351 -37.501-33. 542 1, .00 32.68 C
ATOM 5588 0 LEU D 126 25.288 -36.773 -33. 221 1 .00 30.70 0ATOM 5588 0 LEU D 126 25.288 -36.773 -33. 221 1 .00 30.70 0
ATOM 5589 N VAL D 127 23.156 -37.461 - 32. 955 1 .00 33.23 NATOM 5589 N VAL D 127 23.156 -37.461-32. 955 1 .00 33.23 N
ATOM 5590 CA VAL D 127 22.882 -36.624 -31. 790 1 .00 33.16 CATOM 5590 CA VAL D 127 22.882 -36.624 -31. 790 1 .00 33.16 C
ATOM 5591 CB VAL D 127 22.002一 35.407 -32. 165 1 ■ 00 32.47 C ATOM 5592 CG1 VAL D 127 22.767 -34.476 - 33.073 1.00 30.65 CATOM 5591 CB VAL D 127 22.002 1 35.407 -32. 165 1 ■ 00 32.47 C ATOM 5592 CG1 VAL D 127 22.767 -34.476-33.073 1.00 30.65 C
ATOM 5593 C62 VAL D 127 20.723 -35.872 -32. 853 1. 00 32.43 CATOM 5593 C62 VAL D 127 20.723 -35.872 -32. 853 1. 00 32.43 C
ATOM 5594 C VAL D 127 22.166 -37.436 -30. 710 1. 00 35.00 CATOM 5594 C VAL D 127 22.166 -37.436 -30. 710 1.00 35.00 C
ATOM 5595 0 VAL D 127 21.611 -38.503 -30. 992 1. 00 35.10 0ATOM 5595 0 VAL D 127 21.611 -38.503 -30. 992 1. 00 35.10 0
ATOM 5596 N SER D 128 22.189 -36.938 -29. 475 1. 00 35.43 NATOM 5596 N SER D 128 22.189 -36.938 -29.475 1. 00 35.43 N
ATOM 5597 CA SER D 128 21.431 -37.557 -28. 388 1. 00 35.57 CATOM 5597 CA SER D 128 21.431 -37.557 -28. 388 1. 00 35.57 C
ATOM 5598 CB SER D 128 22.198一 37.471 - 27. 073 1. 00 36.43 CATOM 5598 CB SER D 128 22.198 1 37.471-27. 073 1. 00 36.43 C
ATOM 5599 OG SER D 128 21.433 - 38.027 -26. 015 1. 00 39.44 0ATOM 5599 OG SER D 128 21.433-38.027 -26. 015 1. 00 39.44 0
ATOM 5600 C SER D 128 20.089 -36.870 - 28. 214 1. 00 35.99 CATOM 5600 C SER D 128 20.089 -36.870-28. 214 1. 00 35.99 C
ATOM 5601 0 SER D 128 19.999 -35.647 -28. 292 1. 00 36.30 0ATOM 5601 0 SER D 128 19.999 -35.647 -28. 292 1. 00 36.30 0
ATOM 5602 N ASN D 129 19.050 - 37.663 -27. 971 1. 00 36.38 NATOM 5602 N ASN D 129 19.050-37.663 -27. 971 1. 00 36.38 N
ATOM 5603 CA ASN D. 129 17.700 - 37.141 -27. 802 1. 00 36.88 CATOM 5603 CA ASN D. 129 17.700-37.141 -27. 802 1.00 36.88 C
ATOM 5604 CB ASN D 129 16.708 -37.927 -28. 670 1. 00 36.94 CATOM 5604 CB ASN D 129 16.708 -37.927 -28. 670 1.00 36.94 C
ATOM 5605 CG ASN D 129 16.902 -37.683 -30. 152 1. 00 35.30 CATOM 5605 CG ASN D 129 16.902 -37.683 -30. 152 1. 00 35.30 C
ATOM 5606 0D1 ASN D 129 17.572 -36.734 -30. 553 1. 00 34.19 0ATOM 5606 0D1 ASN D 129 17.572 -36.734 -30. 553 1. 00 34.19 0
ATOM 5607 ND2 ASN D 129 16.311 -38.541 -30. 977 1. 00 33.70 NATOM 5607 ND2 ASN D 129 16.311 -38.541 -30. 977 1. 00 33.70 N
ATOM 5608 C ASN D 129 17.242 -37.213 - 26. 347 1. 00 38.33 CATOM 5608 C ASN D 129 17.242 -37.213-26. 347 1. 00 38.33 C
ATOM 5609 0 ASN D 129 16.051 -37.355 -26. 078 1. 00 38.51 0ATOM 5609 0 ASN D 129 16.051 -37.355 -26. 078 1. 00 38.51 0
ATOM 5610 N ILE D 130 18.176 -37.118 -25. 408 1. ,00 39.64 NATOM 5610 N ILE D 130 18.176 -37.118 -25. 408 1., 00 39.64 N
ATOM 5611 CA ILE D 130 17.824 -37.293 -24. 007 1. ,00 42.76 CATOM 5611 CA ILE D 130 17.824 -37.293 -24. 007 1., 00 42.76 C
ATOM 5612 CB ILE D 130 19.077 - 37.555 - 23. 138 1. .00 44.38 CATOM 5612 CB ILE D 130 19.077-37.555-23. 138 1. .00 44.38 C
ATOM 5613 CG2 ILE D 130 18.765 -37.290 -21. 677 1. .00 45.37 CATOM 5613 CG2 ILE D 130 18.765 -37.290 -21. 677 1. .00 45.37 C
ATOM 5614 CG1 ILE D 130 19.549 -39.000 -23.336 1. .00 46.42 CATOM 5614 CG1 ILE D 130 19.549 -39.000 -23.336 1. .00 46.42 C
ATOM 5615 CD1 ILE D 130 20.715 - 39.401 -22. 443 1. .00 47.11 CATOM 5615 CD1 ILE D 130 20.715-39.401 -22. 443 1. .00 47.11 C
ATOM 5616 C ILE D 130 17.043 - 36. 123 -23. 418 1, .00 43.41 CATOM 5616 C ILE D 130 17.043-36. 123 -23. 418 1, .00 43.41 C
ATOM 5617 0 ILE D 130 16.035 -36. 332 - 22. 742 1, .00 44.57 0ATOM 5617 0 ILE D 130 16.035 -36. 332-22. 742 1, .00 44.57 0
ATOM 5618 N ASP D 131 17.495一 34. 899 -23. 674 1, .00 42.35 NATOM 5618 N ASP D 131 17.495 1 34. 899 -23. 674 1, .00 42.35 N
ATOM 5619 CA ASP D 131 16.837 -33. 721 -23. 111 1 ■ 00 43.21 CATOM 5619 CA ASP D 131 16.837 -33. 721 -23. 111 1 ■ 00 43.21 C
ATOM 5620 CB ASP D 131 17.848 -32. 588 -22. 925 1 .00 48.92 CATOM 5620 CB ASP D 131 17.848 -32. 588 -22. 925 1 .00 48.92 C
ATOM 5621 CG ASP D 131 19.147 - 33. 057 -22. 286 1 .00 54.22 CATOM 5621 CG ASP D 131 19.147-33. 057 -22. 286 1 .00 54.22 C
ATOM 5622 0D1 ASP D 131 19.111 —34. 019 -21. 484 1 .00 55.78 0ATOM 5622 0D1 ASP D 131 19.111 —34. 019 -21. 484 1 .00 55.78 0
ATOM 5623 0D2 ASP D 131 20.207 - 32. 460 -22. 592 1 .00 56.74 0ATOM 5623 0D2 ASP D 131 20.207-32. 460 -22. 592 1 .00 56.74 0
ATOM 5624 C ASP D 131 15.692 -33. 225 -23. 995 1 .00 41.47 CATOM 5624 C ASP D 131 15.692 -33. 225 -23. 995 1 .00 41.47 C
ATOM 5625 0 ASP D 131 15.119 -32. 165 -23. 747 1 ■ 00 41.04 0ATOM 5625 0 ASP D 131 15.119 -32. 165 -23.747 1 ■ 00 41.04 0
ATOM 5626 N GLU D 132 15.369 -33. 996 - 25. 027 1 .00 38.81 NATOM 5626 N GLU D 132 15.369 -33. 996-25. 027 1 .00 38.81 N
ATOM 5627 CA 6LU D 132 14.404 -33. 577 -26. 034 1 .00 36.20 C ATOM 5628 CB 6LU D 132 14.570 -34.438一 27.290 1.00 34.98 CATOM 5627 CA 6LU D 132 14.404 -33. 577 -26. 034 1 .00 36.20 C ATOM 5628 CB 6LU D 132 14.570 -34.438 One 27.290 1.00 34.98 C
ATOM 5629 CG 6LU D 132 13.443 -34.321 - 28.302 1. 00 34.23 CATOM 5629 CG 6LU D 132 13.443 -34.321-28.302 1.00 34.23 C
ATOM 5630 CD 6LU D 132 13.588 -35.300 -29.454 1. 00 34.78 CATOM 5630 CD 6LU D 132 13.588 -35.300 -29.454 1.00 34.78 C
ATOM 5631 0E1 GLU D 132 14.402 - 35.029 - 30.366 1. 00 36.52 0ATOM 5631 0E1 GLU D 132 14.402-35.029-30.366 1.00 36.52 0
ATOM 5632 0E2 6LU D 132 12.893 -36.339 -29.447 1. 00 32.31 0ATOM 5632 0E2 6LU D 132 12.893 -36.339 -29.447 1. 00 32.31 0
ATOM 5633 C GLU D 132 12.972 -33.690 -25.512 1. 00 36.15 CATOM 5633 C GLU D 132 12.972 -33.690 -25.512 1. 00 36.15 C
ATOM 5634 0 GLU D 132 12.585 -34.715 -24.953 1. 00 38.00 0ATOM 5634 0 GLU D 132 12.585 -34.715 -24.953 1.00 38.00 0
ATOM 5635 N ARG D 133 12.182 -32.638 -25. 695 1. 00 33.28 NATOM 5635 N ARG D 133 12.182 -32.638 -25. 695 1. 00 33.28 N
ATOM 5636 CA ARG D 133 10.788 - 32.662 -25. 266 1. 00 31.64 CATOM 5636 CA ARG D 133 10.788-32.662 -25. 266 1. 00 31.64 C
ATOM 5637 CB AR6 D 133 10.284 -31. 234 -25. 036 1. 00 31.26 CATOM 5637 CB AR6 D 133 10.284 -31. 234 -25. 036 1. 00 31.26 C
ATOM 5638 C6 ARG D 133 8.769 -31. 104 -24. 946 1. 00 30.34 C ATOM 5638 C6 ARG D 133 8.769 -31. 104 -24. 946 1. 00 30.34 C
1  1
ATOM 5639 CD ARG D 133 8.199 -31 8.5 9 •59 -23. 838 1. 00 29.61 C ATOM 5639 CD ARG D 133 8.199 -31 8.5 9 • 59 -23. 838 1. 00 29.61 C
ATOM 5640 NE ARG D 133 6.758 -31. 784 - 23. 704 1. 00 29.67 _ NATOM 5640 NE ARG D 133 6.758 -31. 784-23. 704 1. 00 29.67 _ N
ATOM 5641 CZ ARG D 133 5.855 -32.477 -24. 388 1. 00 32.05 CATOM 5641 CZ ARG D 133 5.855 -32.477 -24. 388 1. 00 32.05 C
ATOM 5642 NH1 ARG D 133 6.245 -33.399 - 25. 255 1. 00 32.13 NATOM 5642 NH1 ARG D 133 6.245 -33.399-25. 255 1. 00 32.13 N
ATOM 5643 NH2 ARG D 133 4.559 -32.242 -24. 216 1. ,00 32.49 NATOM 5643 NH2 ARG D 133 4.559 -32.242 -24. 216 1., 00 32.49 N
ATOM 5644 C ARG D 133 9.908 -33.356 -26. 301 1. 00 31.31 CATOM 5644 C ARG D 133 9.908 -33.356 -26. 301 1. 00 31.31 C
ATOM 5645 0 ARG D 133 9.035 -34.155 -25. 962 1. ,00 29.18 0ATOM 5645 0 ARG D 133 9.035 -34.155 -25. 962 1., 00 29.18 0
ATOM 5646 N MET D 134 10.140 - 33.051 -27. 571 1. ,00 30.41 NATOM 5646 N MET D 134 10.140-33.051 -27. 571 1., 00 30.41 N
ATOM 5647 CA MET D 134 9.309 -33.616 -28. 615 1. .00 30.10 CATOM 5647 CA MET D 134 9.309 -33.616 -28.615 1. .00 30.10 C
ATOM 5648 CB MET D 134 8.006 -32.825 -28. 722 1, .00 31.12 CATOM 5648 CB MET D 134 8.006 -32.825 -28.722 1, .00 31.12 C
ATOM 5649 CG MET D 134 7.009 -33.397 - 29. 705 1. .00 33.35 CATOM 5649 CG MET D 134 7.009 -33.397-29. 705 1. .00 33.35 C
ATOM 5650 SD MET D 134 5.425 -32.553 -29.610 1, .00 36.04 SATOM 5650 SD MET D 134 5.425 -32.553 -29.610 1, .00 36.04 S
ATOM 5651 CE MET D 134 5.922 -30.933 - 30.045 1 .00 36.35 CATOM 5651 CE MET D 134 5.922 -30.933-30.045 1 .00 36.35 C
ATOM 5652 C MET D 134 10.018 - 33.633 -29.964 1, .00 30.22 CATOM 5652 C MET D 134 10.018-33.633 -29.964 1, .00 30.22 C
ATOM 5653 0 MET D 134 10.730 - 32. 687 - 30.325 1 .00 30.24 0ATOM 5653 0 MET D 134 10.730-32. 687-30.325 1 .00 30.24 0
ATOM 5654 N ALA 0 135 9.816 - 34. 721 - 30. 701 1 • 00 26.99 NATOM 5654 N ALA 0 135 9.816-34. 721-30. 701 1 • 00 26.99 N
ATOM 5655 CA ALA D 135 10.272 - 34. 818 -32. 078 1 ■ 00 24.95 CATOM 5655 CA ALA D 135 10.272-34. 818 -32. 078 1 ■ 00 24.95 C
ATOM 5656 CB ALA D 135 11.102 -36. 078 - 32. 274 1 ■ 00 24.67 CATOM 5656 CB ALA D 135 11.102 -36. 078-32. 274 1 ∎ 00 24.67 C
ATOM 5657 C ALA D 135 9.072 - 34. 846 -33. 005 1 .00 23.55 CATOM 5657 C ALA D 135 9.072-34. 846 -33. 005 1 .00 23.55 C
ATOM 5658 0 ALA D 135 8.067 -35. 480 - 32. 711 1 • 00 20.68 0ATOM 5658 0 ALA D 135 8.067 -35. 480-32. 711 1 • 00 20.68 0
ATOM 5659 N LEU D 136 9.190 -34. 145 -34. , 124 1 .00 23.75 NATOM 5659 N LEU D 136 9.190 -34. 145 -34., 124 1 .00 23.75 N
ATOM 5660 CA LEU D 136 8.181 -34. 162 - 35. 169 1 .00 24.20 CATOM 5660 CA LEU D 136 8.181 -34. 162-35. 169 1 .00 24.20 C
ATOM 5661 CB LEU D 136 7.674 - 32. 742 -35. ,431 1 .00 26.26 CATOM 5661 CB LEU D 136 7.674-32. 742 -35., 431 1 .00 26.26 C
ATOM 5662 CG LEU D 136 6.569 -32. 136 - 34. ,552 1 .00 29.58 CATOM 5662 CG LEU D 136 6.569 -32. 136-34., 552 1 .00 29.58 C
ATOM 5663 CD1 LEU D 136 6.482 —32. 855 -33. .225 1 .00 31.27 C 98T ATOM 5663 CD1 LEU D 136 6.482 --32. 855 -33..225 1 .00 31.27 C 98T
0 5z οε 00" ι 8ΐε a law ao 669S W01V 0 5z οε 00 "ι 8ΐε a law ao 669S W01V
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0 29 S3 00, L 89^ L - η£ "9ε- 98 OH a oyd vo 2693 W01V0 29 S3 00, L 89 ^ L-η £ "9ε- 98 OH a oyd vo 2693 W01V
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N 83 '92 00' ι LVL •9fr - Ot-9 "9ε- 901 ·9 a OMd N 0699 WOIVN 83 '92 00 'ι LVL • 9fr-Ot-9 "9ε- 901 9 a OMd N 0699 WOIV
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0 S6'92 00' ι 9η 098 '9C- 660 "9 6ε i a dSV 0 8899 WOIV0 S6'92 00 'ι 9η 098' 9C- 660 "9 6ε i a dSV 0 8899 WOIV
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0 99 '93 00 V LZL 096 '9S- Wfr ' . 6ε L a dSV vo C899 IN01V0 99 '93 00 V LZL 096 '9S- Wfr'. 6ε L adSV vo C899 IN01V
N 9ί ' 2 00 Ύ ■Sfr - 661 '9ε- L9Z 'L 6 L a dSV N Z899 WOIVN 9ί '2 00 ΎSfr-661' 9ε- L9Z 'L 6 L a dSV N Z899 WOIV
0 ει. ζζ 00 IV6 ■zv- L90 '9C- on 6 8ε i a IVA 0 L899 WOIV0 ει. Ζζ 00 IV6 ■ zv- L90 '9C- on 6 8ε i a IVA 0 L899 WOIV
0 si τζ 00 969 . - 6S8 '9ε- 893 '8 8 i a IVA 0 0899 WOIV0 si τζ 00 969 .- 6S8 '9ε- 893' 8 8 i a IVA 0 0899 WOIV
0 8ん '02 00 8Z.8 •i^- ιζζ εε- ½S '6 a IVA 390 6L99 WOIV0 8 '02 00 8Z.8 i ^-ιζζ εε- ½S '6 a IVA 390 6L99 WOIV
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0 ητζ 00 999 ■Lfr- 699 'εε - 090 '8 8 i G ΊΥΛ ao LL9 IN01V0 ητζ 00 999Lfr- 699 'εε-090' 8 8 i G ΊΥΛ ao LL9 IN01V
0 66' 13 00 ■ν £ 'Lfr- ωι -9ε- 0/18 'L 8ε L a IVA vo 9乙 9S WOIV0 66 '13 00 ν £' Lfr- ωι -9ε- 0/18 'L 8ε L a IVA vo 9 O 9S WOIV
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0 08 Ζ 00 m ·6ε - LL6 ZIO '8 LZl a 311 0 EZ.99 WOIV0 08 Ζ 00 m6ε-LL6 ZIO '8 LZl a 311 0 EZ.99 WOIV
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0 ZV61 00 ■6ε- 91L '8S - 231 '6 ん ει G 311 390 0Z.99 IN01V0 ZV61 00 6ε- 91L '8S-231' 6 ει G 311 390 0Z.99 IN01V
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0 8t-'6L 00 -L 390 '8S - 03S '9ε- εζ.8 ·8 LZi a 311 vo 8999 WOIV0 8t-'6L 00 -L 390 '8S-03S' 9ε- εζ.8 8 LZi a 311 vo 8999 WOIV
N n iz 00 8178 '9 - 06 '98- ½ε '8 L£i a 311 N .999 WOIVN n iz 00 8178 '9-06 '98-½ε' 8 L £ i a 311 N .999 WOIV
0 ΟΖ ' Ζ 00 910'ζ.ε- 8 .6 99 L a nai 0 9999 WOIV0 ΟΖ 'Ζ 00 910'ζ.ε- 8.6 99 L a nai 0 9999 WOIV
0 00 ■L '9ε- 9ZL ε， 938 "8 9SI G Π31 0 9999 WOIV0 00 L '9ε-9ZL ε, 938 "8 9SI G Π31 0 9999 WOIV
0 ·οε 00 ■L Ζ5Ζ ε - 9 Όε- ½8 ,9 9SL a Π3Ί ZQO W99 WOIV 0 · οε 00 ■ L Ζ5Ζ ε-9 Όε- ½8, 9 9SL a Π3Ί ZQO W99 WOIV
^LlLO/LOOZdT/lDd 0 S0/600Z OAV ATOM 5700 GG MET D 141 3. 680 -39. 315 - 50. 370 1. 00 31. 32 C^ LlLO / LOOZdT / lDd 0 S0 / 600Z OAV ATOM 5700 GG MET D 141 3. 680 -39. 315-50. 370 1. 00 31. 32 C
ATOM 5701 SD MET D 141 4. 111 - 39. 924 - 52. 006 1. 00 38. 13 SATOM 5701 SD MET D 141 4. 111-39. 924-52. 006 1. 00 38. 13 S
ATOM 5702 CE MET D 141 2. 494 -40. 024 -52. 741 1. 00 32. 76 CATOM 5702 CE MET D 141 2. 494 -40. 024 -52. 741 1. 00 32. 76 C
ATOM 5703 C MET D 141 3. 840 -41. 032 - 46. 907 1. 00 32. 28 CATOM 5703 C MET D 141 3. 840 -41. 032-46. 907 1. 00 32. 28 C
ATOM 5704 0 MET D 141 4. 953 -41. 550 -46. 824 1. 00 32. 72 0ATOM 5704 0 MET D 141 4. 953 -41. 550 -46. 824 1. 00 32. 72 0
ATOM 5705 N LEU D 142 2. 816 - 41. 427 -46. 157 1. 00 33. 84 NATOM 5705 N LEU D 142 2. 816-41. 427 -46. 157 1. 00 33. 84 N
ATOM 5706 CA LEU D 142 2. 926 -42. 628 -45. 342 1. 00 32. 54 CATOM 5706 CA LEU D 142 2. 926 -42. 628 -45. 342 1. 00 32. 54 C
ATOM 5707 CB LEU D 142 2. 295 -42. 414 -43. 971 1. 00 30. 71 CATOM 5707 CB LEU D 142 2. 295 -42. 414 -43. 971 1. 00 30. 71 C
ATOM 5708 CG LEU D 142 2. 704 - 43. 503 -42. 978 1. 00 27. 98 CATOM 5708 CG LEU D 142 2. 704-43. 503 -42. 978 1. 00 27. 98 C
ATOM 5709 CD1 LEU D 142 3. 961 -43. 072 -42. 299 1. 00 28. 61 CATOM 5709 CD1 LEU D 142 3. 961 -43. 072 -42. 299 1. 00 28. 61 C
0 0  0 0
ATOM 5710 CD2 LEU D 142 1. 631 - 43. 739 -41. 958 1. 00 27. 58 C ATOM 5710 CD2 LEU D 142 1. 631-43. 739 -41. 958 1. 00 27. 58 C
ATOM 5711 C LEU D 142 2. 210 -43. 761 -46. 064 1. 00 33. 03 CATOM 5711 C LEU D 142 2. 210 -43. 761 -46. 064 1. 00 33. 03 C
ATOM 5712 0 LEU D 142 0. 994 - 43. 933 -45. 921 1. 00 35. 03 0ATOM 5712 0 LEU D 142 0. 994-43. 933 -45. 921 1. 00 35. 03 0
ATOM 5713 N ALA D 143 2. 966 -44. 525 - 46. 848 1. 00 32. 20 NATOM 5713 N ALA D 143 2. 966 -44. 525-46. 848 1. 00 32. 20 N
ATOM 5714 CA ALA D 143 2. 383 -45. 521 - 47. 740 1. 00 32. 37 CATOM 5714 CA ALA D 143 2. 383 -45. 521-47. 740 1. 00 32. 37 C
ATOM 5715 CB ALA D 143 3. 244 -45. 665 -48. 998 1. 00 31. 63 CATOM 5715 CB ALA D 143 3. 244 -45. 665 -48. 998 1. 00 31. 63 C
ATOM 5716 C ALA D 143 2. 236 -46. 869 -47. 036 1 , , 00 32. 72 CATOM 5716 C ALA D 143 2. 236 -46. 869 -47. 036 1,, 00 32. 72 C
ATOM 5717 0 ALA D 143 -47. 242 -46. 633 1. 00 33. 02 0ATOM 5717 0 ALA D 143 -47. 242 -46. 633 1. 00 33. 02 0
ATOM 5718 N THR D 144 3. 341 - 47. 594 -46. 884 1. , 00 34. 05 NATOM 5718 N THR D 144 3. 341-47. 594 -46. 884 1., 00 34. 05 N
ATOM 5719 CA THR D 144 3. 347 -48. 832 -46. 099 1. , 00 35. 24 CATOM 5719 CA THR D 144 3. 347 -48. 832 -46. 099 1., 00 35. 24 C
ATOM 5720 CB THR D 144 4. 386 -49. 841 - 46. 639 1. , 00 35. 58 CATOM 5720 CB THR D 144 4. 386 -49. 841-46. 639 1., 00 35. 58 C
ATOM 5721 0G1 THR D 144 5. 699 -49. 279 -46. 539 1. , 00 36. 83 0ATOM 5721 0G1 THR D 144 5. 699 -49. 279 -46. 539 1., 00 36. 83 0
ATOM 5722 CG2 THR D 144 4. 103 - 50. 178 -48. 090 1. , 00 36. 22 CATOM 5722 CG2 THR D 144 4. 103-50. 178 -48. 090 1., 00 36. 22 C
ATOM 5723 C THR D 144 3. 678 - 48. 551 -44. 632 1. . 00 35. 41 CATOM 5723 C THR D 144 3. 678-48. 551 -44. 632 1.. 00 35. 41 C
ATOM 5724 0 THR D 144 3. 212 -49. 255 -43. 744 1. . 00 35. 66 0ATOM 5724 0 THR D 144 3. 212 -49. 255 -43. 744 1.. 00 35. 66 0
ATOM 5725 N GLY D 145 4. 486 -47. 520 - 44. 390 1. , 00 34. 99 NATOM 5725 N GLY D 145 4. 486 -47. 520-44. 390 1., 00 34. 99 N
ATOM 5726 CA 6LY D 145 4. 871 - 47. 166 -43. 035 1. . 00 33. 64 CATOM 5726 CA 6LY D 145 4. 871-47. 166 -43. 035 1.. 00 33. 64 C
ATOM 5727 C GLY D 145 6. 333 - 47. 438 -42. 721 1. . 00 33. 25 CATOM 5727 C GLY D 145 6. 333-47. 438 -42. 721 1.. 00 33. 25 C
ATOM 5728 0 GLY D 145 6. 826 - 47. 070 -41. 655 1 , . 00 31. 97 0ATOM 5728 0 GLY D 145 6. 826-47. 070 -41. 655 1,. 00 31. 97 0
ATOM 5729 N GLY D 146 7. 032 -48. 080 -43. 654 1. . 00 33. 06 NATOM 5729 N GLY D 146 7. 032 -48. 080 -43. 654 1.. 00 33. 06 N
ATOM 5730 CA GLY D 146 8. 390 -48. 521 -43. 386 1 , . 00 30. 84 CATOM 5730 CA GLY D 146 8. 390 -48. 521 -43. 386 1,. 00 30. 84 C
ATOM 5731 C GLY D 146 9. 336 -47. 413 -42. 961 1 , . 00 28. 86 GATOM 5731 C GLY D 146 9. 336 -47. 413 -42. 961 1,. 00 28. 86 G
ATOM 5732 0 GLY D 146 9. 991 -47. 509 - 41. 925 1 , . 00 30. 13 0ATOM 5732 0 GLY D 146 9. 991 -47. 509-41. 925 1,. 00 30. 13 0
ATOM 5733 N SER D 147 9. 406 - 46. 353 -43. 754 1 , . 00 27. 28 NATOM 5733 N SER D 147 9. 406-46. 353 -43. 754 1,. 00 27. 28 N
ATOM 5734 CA SER D 147 10. 309 - 45. 247 - 43. 469 1. . 00 26. 18 CATOM 5734 CA SER D 147 10. 309-45. 247-43. 469 1.. 00 26. 18 C
ATOM 5735 CB SER D 147 10. 153一 44, 152 -44. 525 1 . 00 26. , 84 C ATOM 5736 OG SER D 147 10.735 -44.536 -45.755 1.00 27.44 0ATOM 5735 CB SER D 147 10. 153 1 44, 152 -44. 525 1. 00 26., 84 C ATOM 5736 OG SER D 147 10.735 -44.536 -45.755 1.00 27.44 0
ATOM 573フ C SER D 147 10.099 - 44.642 -42.087 1. 00 25.02 CATOM 573 C C SER D 147 10.099-44.642 -42.087 1.00 25.02 C
ATOM 5738 0 SER D 147 11.062 -44.412 -41.356 1. 00 26.24 0ATOM 5738 0 SER D 147 11.062 -44.412 -41.356 1.00 26.24 0
ATOM 5739 N VAL D 148 8.847 -44.377 -41.731 1. 00 22.56 NATOM 5739 N VAL D 148 8.847 -44.377 -41.731 1. 00 22.56 N
ATOM 5740 CA VAL D 148 8.534 -43.721 -40.459 1. 00 23.30 CATOM 5740 CA VAL D 148 8.534 -43.721 -40.459 1.00 23.30 C
ATOM 5741 CB VAL D 148 7.064 -43.233 -40.431 1. 00 23.73 CATOM 5741 CB VAL D 148 7.064 -43.233 -40.431 1. 00 23.73 C
ATOM 5742 CG1 VAL D 148 6.711 -42.717 -39.038 1. 00 26.91 CATOM 5742 CG1 VAL D 148 6.711 -42.717 -39.038 1. 00 26.91 C
ATOM 5743 CG2 VAL D 148 6.872 -42.113 -41.443 1. 00 24.47 CATOM 5743 CG2 VAL D 148 6.872 -42.113 -41.443 1.00 24.47 C
ATOM 5744 C VAL D 148 8.770 -44.637 -39.260 1. 00 22.46 GATOM 5744 C VAL D 148 8.770 -44.637 -39.260 1. 00 22.46 G
ATOM 5745 0 VAL D 148 9.412 -44.258 -38.274 1. 00 20.55 0ATOM 5745 0 VAL D 148 9.412 -44.258 -38.274 1. 00 20.55 0
ATOM 5746 N ILE D 149 8.252 -45.853 -39.355 1. 00 25.88 NATOM 5746 N ILE D 149 8.252 -45.853 -39.355 1. 00 25.88 N
ATOM 5747 CA ILE D 149 8.436 -46.842 - 38.304 1. 00. 27.33 CATOM 5747 CA ILE D 149 8.436 -46.842-38.304 1. 00. 27.33 C
ATOM 5748 CB ILE D 149 ' 7.756 -48.175 -38.686 1. 00 27.85 ― CATOM 5748 CB ILE D 149 '7.756 -48.175 -38.686 1. 00 27.85 ― C
ATOM 5749 CG2 ILE D 149 8.185 -49.259 -37.726 1. 00 22.43 CATOM 5749 CG2 ILE D 149 8.185 -49.259 -37.726 1. 00 22.43 C
ATOM 5750 CG1 ILE D 149 6.229 - 47.983 - 38.712 1. 00 26.19 CATOM 5750 CG1 ILE D 149 6.229-47.983-38.712 1. 00 26.19 C
ATOM 5751 CD1 ILE D 149 5.451 -49.122 - 39.369 1. 00 24.85 CATOM 5751 CD1 ILE D 149 5.451 -49.122-39.369 1.00 24.85 C
ATOM 5752 C ILE D 149 9.922 -47.074 -38.045 1. ,00 27.46 CATOM 5752 C ILE D 149 9.922 -47.074 -38.045 1., 00 27.46 C
ATOM 5753 0 ILE D 149 10.360 -47.145 - 36.896 1. ,00 29.86 0ATOM 5753 0 ILE D 149 10.360 -47.145-36.896 1., 00 29.86 0
ATOM 5754 N ALA D 150 10.705 -47.162 -39.110 1. .00 27.10 NATOM 5754 N ALA D 150 10.705 -47.162 -39.110 1. .00 27.10 N
ATOM 5755 CA ALA D 150 12.146 -47.306 -38.945 1. .00 27.95 CATOM 5755 CA ALA D 150 12.146 -47.306 -38.945 1. .00 27.95 C
ATOM 5756 CB ALA D 150 12.815 - 47· 564 - 40.293 1. .00 26.89 CATOM 5756 CB ALA D 150 12.815-47 564-40.293 1. .00 26.89 C
ATOM 5757 C ALA D 150 12.724 -46.053 -38.306 1. .00 28.07 CATOM 5757 C ALA D 150 12.724 -46.053 -38.306 1. .00 28.07 C
ATOM 5758 0 ALA D 150 1'3.569 - 46.139 -37.419 1. .00 29.73 0ATOM 5758 0 ALA D 150 1'3.569-46.139 -37.419 1. .00 29.73 0
ATOM 5759 N THR D 151 12.264 -44.884 -38.745 1, .00 27.22 NATOM 5759 N THR D 151 12.264 -44.884 -38.745 1, .00 27.22 N
ATOM 5760 CA THR D 151 12.774 -43.637 -38.187 1, .00 25.63 CATOM 5760 CA THR D 151 12.774 -43.637 -38.187 1, .00 25.63 C
ATOM 5761 CB THR D 151 12.216 -42.405 -38.934 1, .00 25.12 CATOM 5761 CB THR D 151 12.216 -42.405 -38.934 1, .00 25.12 C
ATOM 5762 061 THR D 151 12.617 -42.462 - 40.307 1 .00 27.33 .0ATOM 5762 061 THR D 151 12.617 -42.462-40.307 1 .00 27.33 .0
ATOM 5763 CG2 THR D 151 12.749 -38.317 1 .00 19.57 CATOM 5763 CG2 THR D 151 12.749 -38.317 1 .00 19.57 C
ATOM 5764 C THR D 151 12.439 -43.513 -36.701 1 .00 25.16 CATOM 5764 C THR D 151 12.439 -43.513 -36.701 1 .00 25.16 C
ATOM 5765 0 THR D 151 13.248 -43.021 -35.920 1 .00 25.33 0ATOM 5765 0 THR D 151 13.248 -43.021 -35.920 1 .00 25.33 0
ATOM 5766 N ILE D 152 11.252 -43.961 -36.303 1 .00 25.40 NATOM 5766 N ILE D 152 11.252 -43.961 -36.303 1 .00 25.40 N
ATOM 5767 CA ILE D 152 10.906 -43.936 -34.883 1 .00 27.04 CATOM 5767 CA ILE D 152 10.906 -43.936 -34.883 1 .00 27.04 C
ATOM 5768 CB ILE D 152 9.452 - 44.349 -34.647 1 .00 28.05 CATOM 5768 CB ILE D 152 9.452-44.349 -34.647 1 .00 28.05 C
ATOM 5769 C62 ILE D 152 9.191 -44.462 -33.148 1 .00 24.50 CATOM 5769 C62 ILE D 152 9.191 -44.462 -33.148 1 .00 24.50 C
ATOM 5770 C61 ILE D 152 8.516 -43.322 -35.297 1 .00 28.02 CATOM 5770 C61 ILE D 152 8.516 -43.322 -35.297 1 .00 28.02 C
ATOM 5771 CD1 ILE D 152 7.123 -43.839 -35.570 1 .00 30.11 C ATOM 5772 C ILE D 152 11.809 -44.859 -34.076 1.00 28.04 CATOM 5771 CD1 ILE D 152 7.123 -43.839 -35.570 1 .00 30.11 C ATOM 5772 C ILE D 152 11.809 -44.859 -34.076 1.00 28.04 C
ATOM 5773 0 ILE D 152 12.214 -44.521 - 32.958 1. 00 28.69 0ATOM 5773 0 ILE D 152 12.214 -44.521-32.958 1.00 28.69 0
ATOM 5774 N ASP D 153 12.133 -46.017 -34.651 1. 00 27.26 NATOM 5774 N ASP D 153 12.133 -46.017 -34.651 1. 00 27.26 N
ATOM 5775 CA ASP D 153 13.091 -46.926 -34.036 1. 00 26.85 CATOM 5775 CA ASP D 153 13.091 -46.926 -34.036 1. 00 26.85 C
ATOM 5776 CB ASP D 153 13.339 - 48.148 -34.931 1. 00 27.17 CATOM 5776 CB ASP D 153 13.339-48.148 -34.931 1.00 27.17 C
ATOM 5777 CG ASP D 153 12.132 -49.070 - 35.023 1. 00 26.88 CATOM 5777 CG ASP D 153 12.132 -49.070-35.023 1.00 26.88 C
ATOM 5778 0D1 ASP D 153 12.068 -49.862 - 35.980 1. 00 28.72 0ATOM 5778 0D1 ASP D 153 12.068 -49.862-35.980 1.00 28.72 0
ATOM 5779 0D2 ASP D 153 - 49.008 -34.143 1. 00 30.59 0ATOM 5779 0D2 ASP D 153-49.008 -34.143 1. 00 30.59 0
ATOM 5780 C ASP D 153 14.402 -46.189 - 33.817 1. 00 26.49 CATOM 5780 C ASP D 153 14.402 -46.189-33.817 1.00 26.49 C
ATOM 5781 0 ASP D 153 14.971 -46.221 -32.726 1. 00 27.86 0ATOM 5781 0 ASP D 153 14.971 -46.221 -32.726 1. 00 27.86 0
ATOM 5782 N LEU D 154 14.870 -45.516 - 34.859 1. 00 26.55 NATOM 5782 N LEU D 154 14.870 -45.516-34.859 1. 00 26.55 N
ATOM 5783 GA LEU D 154 16.086 -44.714 - 34.776 1. 00 27.20 CATOM 5783 GA LEU D 154 16.086 -44.714-34.776 1. 00 27.20 C
ATOM 5784 CB LEU D 154 16.321 -43.979 -36.099 1. 00 26.52 CATOM 5784 CB LEU D 154 16.321 -43.979 -36.099 1.00 26.52 C
ATOM 5785 CG LEU D 154 17.744 -44.002 - 36.663 1. 00 29.38 CATOM 5785 CG LEU D 154 17.744 -44.002-36.663 1. 00 29.38 C
ATOM 5786 CD1 LEU D 154 17.969 -42.790 -37.580 1. 00 23.28 CATOM 5786 CD1 LEU D 154 17.969 -42.790 -37.580 1. 00 23.28 C
ATOM 5787 CD2 LEU D 154 18.735 -43.998 - 35.526 1. 00 26.23 CATOM 5787 CD2 LEU D 154 18.735 -43.998-35.526 1. 00 26.23 C
ATOM 5788 C LEU D 154 15.990 -43.694 - 33.637 1. 00 27.08 CATOM 5788 C LEU D 154 15.990 -43.694-33.637 1. 00 27.08 C
ATOM 5789 0 LEU D 154 16.875 -43.636 -32.773 1. .00 27.88 0ATOM 5789 0 LEU D 154 16.875 -43.636 -32.773 1. .00 27.88 0
ATOM 5790 N LEU D 155 14.915 - 42.899 -33.631 1. .00 24.94 NATOM 5790 N LEU D 155 14.915-42.899 -33.631 1. .00 24.94 N
ATOM 5791 CA LEU D 155 14.761 -41.817 -32.651 1. 00 24.55 CATOM 5791 CA LEU D 155 14.761 -41.817 -32.651 1. 00 24.55 C
ATOM 5792 CB LEU D 155 13.536 -40.946 -32.982 1. ,00 23.09 CATOM 5792 CB LEU D 155 13.536 -40.946 -32.982 1., 00 23.09 C
ATOM 5793 CG LEU D 155 13.508 -40.084 - 34.255 1. ,00 21.66 CATOM 5793 CG LEU D 155 13.508 -40.084-34.255 1., 00 21.66 C
ATOM 5794 CD1 LEU D 155 12.334 -39.124 -34.157 1. ,00 22.14 CATOM 5794 CD1 LEU D 155 12.334 -39.124 -34.157 1., 00 22.14 C
ATOM 5795 CD2 LEU D 155 14.804 - 39.297 -34.422 1. ,00 18.64 CATOM 5795 CD2 LEU D 155 14.804-39.297 -34.422 1., 00 18.64 C
ATOM 5796 C LEU D 155 14.625 -42.338 -31.219 1. ,00 25.36 CATOM 5796 C LEU D 155 14.625 -42.338 -31.219 1., 00 25.36 C
ATOM 5797 0 LEU D 155 15.205 -41.777 - 30.293 1. ,00 22.92 0ATOM 5797 0 LEU D 155 15.205 -41.777-30.293 1., 00 22.92 0
ATOM 5798 N LYS D 156 13.854 -43.411 - 31.045 1. .00 28.04 NATOM 5798 N LYS D 156 13.854 -43.411-31.045 1. .00 28.04 N
ATOM 5799 CA LYS D 156 13.644 - 43.993 -29.721 1. .00 29.73 CATOM 5799 CA LYS D 156 13.644-43.993 -29.721 1. .00 29.73 C
ATOM 5800 CB LYS D 156 12.595 - 45.116 -29.782 1. .00 29.70 CATOM 5800 CB LYS D 156 12.595-45.116 -29.782 1. .00 29.70 C
ATOM 5801 CG LYS D 156 11.157 -44.605 - 29.605 1, .00 30.44 CATOM 5801 CG LYS D 156 11.157 -44.605-29.605 1, .00 30.44 C
ATOM 5802 CD LYS D 156 10.115 -45.640 - 30.006 1, .00 31.42 CATOM 5802 CD LYS D 156 10.115 -45.640-30.006 1, .00 31.42 C
ATOM 5803 CE LYS D 156 8.723 -45.233 -29.533 1, .00 32.65 CATOM 5803 CE LYS D 156 8.723 -45.233 -29.533 1, .00 32.65 C
ATOM 5804 NZ LYS D 156 7.671 -46.197 -29.993 1, .00 34.21 NATOM 5804 NZ LYS D 156 7.671 -46.197 -29.993 1, .00 34.21 N
ATOM 5805 C LYS D 156 14.939 -44.510 -29.113 1, .00 29.82 CATOM 5805 C LYS D 156 14.939 -44.510 -29.113 1, .00 29.82 C
ATOM 5806 0 LYS D 156 15.256 -44.184 - 27.967 1 .00 27.80 0ATOM 5806 0 LYS D 156 15.256 -44.184-27.967 1 .00 27.80 0
ATOM 5807 N LYS D 157 15.701 -45.288 -29.883 1 .00 32.16 N ATOM 5808 CA LYS D 157 17.029 - 45.721 -29.438 1.00 32.40 CATOM 5807 N LYS D 157 15.701 -45.288 -29.883 1 .00 32.16 N ATOM 5808 CA LYS D 157 17.029-45.721 -29.438 1.00 32.40 C
ATOM 5809 CB LYS D 157 17.755 -46. 499 -30.533 1. 00 35.10 CATOM 5809 CB LYS D 157 17.755 -46. 499 -30.533 1. 00 35.10 C
ATOM 5810 C6 LYS D 157 19.249 -46. 643 -30.262 1. 00 40.62 CATOM 5810 C6 LYS D 157 19.249 -46. 643 -30.262 1.00 40.62 C
ATOM 5811 CD LYS D 157 19.883 -47. 759 -31. 088 1. 00 46.06 CATOM 5811 CD LYS D 157 19.883 -47. 759 -31. 088 1. 00 46.06 C
ATOM 5812 CE LYS D 157 20.444 -48. 866 -30.191 1. 00 50.34 CATOM 5812 CE LYS D 157 20.444 -48. 866 -30.191 1. 00 50.34 C
ATOM 5813 NZ LYS D 157 19.377 -49. 557 -29.396 1. 00 49.84 NATOM 5813 NZ LYS D 157 19.377 -49. 557 -29.396 1. 00 49.84 N
ATOM 5814 C LYS D 157 17.907 —44. 553 - 29.011 1. 00 31.80 CATOM 5814 C LYS D 157 17.907 —44. 553-29.011 1. 00 31.80 C
ATOM 5815 0 LYS D 157 18.632 -44. 648 -28. 021 1. 00 34.15 0ATOM 5815 0 LYS D 157 18.632 -44. 648 -28. 021 1. 00 34.15 0
ATOM 5816 N ALA D 158 17.843 -43. 452 - 29. 755 1. 00 30.89 NATOM 5816 N ALA D 158 17.843 -43. 452-29. 755 1. 00 30.89 N
ATOM 5817 CA ALA D 158 18.603 -42. 250 - 29. 412 1. 00 29.31 CATOM 5817 CA ALA D 158 18.603 -42. 250-29. 412 1. 00 29.31 C
ATOM 5818 CB ALA D 158 18.645 -41. 296 -30. 609 1. 00 29.53 CATOM 5818 CB ALA D 158 18.645 -41. 296 -30. 609 1. 00 29.53 C
ATOM 5819 C ALA D 158 18.027 -41. 526 -28. 190 1. 00 29.14 CATOM 5819 C ALA D 158 18.027 -41. 526 -28. 190 1. 00 29.14 C
ATOM 5820 0 ALA D 158 18.634 - 40. 600 -27. 667 1. 00 27.79 . 0ATOM 5820 0 ALA D 158 18.634-40. 600 -27. 667 1. 00 27.79. 0
ATOM 5821 N GLY D 159 16.853 -41. 939 - 27. 737 1. 00 29.38 NATOM 5821 N GLY D 159 16.853 -41. 939-27. 737 1. 00 29.38 N
ATOM 5822 CA 6LY D 159 16.359 -41. 413 -26. 477 1. 00 30.79 CATOM 5822 CA 6LY D 159 16.359 -41. 413 -26. 477 1. 00 30.79 C
ATOM 5823 C GLY D 159 15.178 -40.461 -26. 555 1. 00 31.56 CATOM 5823 C GLY D 159 15.178 -40.461 -26. 555 1. 00 31.56 C
ATOM 5824 0 GLY D 159 14.850 - 39.809 - 25. 566 1. 00 32.78 0ATOM 5824 0 GLY D 159 14.850-39.809-25. 566 1. 00 32.78 0
ATOM 5825 N SER D 160 14.526 -40.378 -27. 710. 1. 00 30.92 NATOM 5825 N SER D 160 14.526 -40.378 -27. 710. 1. 00 30.92 N
ATOM 5826 CA SER D 160 13.310 -39.580 -27. 819 1. 00 .31.34 CATOM 5826 CA SER D 160 13.310 -39.580 -27. 819 1. 00 .31.34 C
ATOM 5827 CB SER D 160 12.855 -39.487 -29. 277 1. 00 30.03 CATOM 5827 CB SER D 160 12.855 -39.487 -29. 277 1. 00 30.03 C
ATOM 5828 OG SER D 160 13.758 - 38.698 - 30. 036 1. .00 29.47 0ATOM 5828 OG SER D 160 13.758-38.698-30. 036 1. .00 29.47 0
ATOM 5829 C SER D 160 12.214 -40.217 -26. 983 1. ,00 32.08 CATOM 5829 C SER D 160 12.214 -40.217 -26. 983 1., 00 32.08 C
ATOM 5830 0 SER D 160 12.055 -41. 439 -26'.989 1. ,00 35.22 0ATOM 5830 0 SER D 160 12.055 -41. 439 -26'.989 1., 00 35.22 0
ATOM 5831 N SER D 161 11.454 -39. 394 -26. 269 1. ,00 31.26 NATOM 5831 N SER D 161 11.454 -39. 394 -26. 269 1., 00 31.26 N
ATOM 5832 CA SER D 161 10.411 - 39. 907 -25. 390 1. .00 29.72 CATOM 5832 CA SER D 161 10.411-39. 907 -25. 390 1. .00 29.72 C
ATOM 5833 CB SER D 161 10.673 -39. 456 - 23. 963 1. .00 29.88 CATOM 5833 CB SER D 161 10.673 -39. 456-23. 963 1. .00 29.88 C
ATOM 5834 OG SER D 161 10.968 -38. 077 -23. 943 1. .00 32.07 0ATOM 5834 OG SER D 161 10.968 -38. 077 -23. 943 1. .00 32.07 0
ATOM 5835 C SER D 161 9.022 -39. 463 -25. 813 1, .00 29.82 CATOM 5835 C SER D 161 9.022 -39. 463 -25. 813 1, .00 29.82 C
ATOM 5836 0 SER D 161 8.026 - 39. 824 -25. 185 1, .00 30.88 0ATOM 5836 0 SER D 161 8.026-39. 824 -25. 185 1, .00 30.88 0
ATOM 5837 N SER D 162 8.952 -38. 676 -26. 877 1, .00 29.13 NATOM 5837 N SER D 162 8.952 -38. 676 -26. 877 1, .00 29.13 N
ATOM 5838 CA SER D 162 7.667 -38. 189 -27. 358 1, .00 27.28 CATOM 5838 CA SER D 162 7.667 -38. 189 -27. 358 1, .00 27.28 C
ATOM 5839 CB SER D 162 7.219 -36. 988 -26. 521 1, .00 27.54 CATOM 5839 CB SER D 162 7.219 -36. 988 -26. 521 1, .00 27.54 C
ATOM 5840 OG SER D 162 5.891 -36. ,631 - 26. ,840 1 • 00 29.72 0ATOM 5840 OG SER D 162 5.891 -36., 631-26., 840 1 • 00 29.72 0
ATOM 5841 C SER D 162 7.766 -37. 797 -28. 827 1 .00 25.47 CATOM 5841 C SER D 162 7.766 -37. 797 -28. 827 1 .00 25.47 C
ATOM 5842 0 SER D 162 8.544 -36. ,921 -29. ,202 1 .00 24.42 0ATOM 5842 0 SER D 162 8.544 -36., 921 -29., 202 1 .00 24.42 0
ATOM 5843 N ILE D 163 6.969一 38. ,451一 29. ,658 1 .00 23.67 N ATOM 5844 CA ILE D 163 7.170 -38.380 -31.093 1.00 22.49 CATOM 5843 N ILE D 163 6.969 One 38., 451 One 29., 658 1 .00 23.67 N ATOM 5844 CA ILE D 163 7.170 -38.380 -31.093 1.00 22.49 C
ATOM 5845 CB ILE D 163 7.838 -39.654 -31.644 1. 00 23.28 CATOM 5845 CB ILE D 163 7.838 -39.654 -31.644 1. 00 23.28 C
ATOM 5846 CG2 ILE D 163 7.942 - 39.557 -33.164 1. 00 20.61 CATOM 5846 CG2 ILE D 163 7.942-39.557 -33.164 1.00 20.61 C
ATOM 5847 CG1 ILE D 163 9.205 -39.856 -30.990 1. 00 24.00 CATOM 5847 CG1 ILE D 163 9.205 -39.856 -30.990 1.00 24.00 C
ATOM 5848 CD1 ILE 0 163 9.725 -41.277 -31.109 1. 00 28.20 CATOM 5848 CD1 ILE 0 163 9.725 -41.277 -31.109 1. 00 28.20 C
ATOM 5849 G ILE D 163 5.846 -38.259 -31.788 1. 00 21.61 CATOM 5849 G ILE D 163 5.846 -38.259 -31.788 1. 00 21.61 C
ATOM 5850 0 ILE D 163 4.950 -39.049 -31.544 1. 00 23.04 0ATOM 5850 0 ILE D 163 4.950 -39.049 -31.544 1.00 23.04 0
ATOM 5851 N LYS D 164 5.732 -37.285 -32.678 1. 00 20.26 NATOM 5851 N LYS D 164 5.732 -37.285 -32.678 1. 00 20.26 N
ATOM 5852 CA LYS D 164 4.573 -37.194 -33.542 1. 00 21.27 CATOM 5852 CA LYS D 164 4.573 -37.194 -33.542 1. 00 21.27 C
ATOM 5853 CB LYS D 164 3.830 -35.893 -33.259 1. 00 21.57 CATOM 5853 CB LYS D 164 3.830 -35.893 -33.259 1.00 21.57 C
ATOM 5854 CG LYS D 164 3.685 - 35.599 -31.786 1. 00 22.05 CATOM 5854 CG LYS D 164 3.685-35.599 -31.786 1.00 22.05 C
ATOM 5855 CD LYS D 164 2.431 -34.806 - 31.525 1. 00 25.59 CATOM 5855 CD LYS D 164 2.431 -34.806-31.525 1. 00 25.59 C
ATOM 5856 CE LYS D 164 2.255 -34.512 -30.047 1. 00 27.58 CATOM 5856 CE LYS D 164 2.255 -34.512 -30.047 1.00 27.58 C
ATOM 5857 NZ LYS D 164 1.029 -33.692 -29.844 1. 00 30.88 NATOM 5857 NZ LYS D 164 1.029 -33.692 -29.844 1. 00 30.88 N
ATOM 5858 C LYS D 164 5.039 - 37.240 - 34.994 1. 00 20.11 CATOM 5858 C LYS D 164 5.039-37.240-34.994 1. 00 20.11 C
ATOM 5859 0 LYS D 164 6.150 -36.813 -35.300 1. 00 19.81 0ATOM 5859 0 LYS D 164 6.150 -36.813 -35.300 1. 00 19.81 0
ATOM 5860 N VAL D 165 4.191 -37.766 - 35.873 1. 00 19.26 NATOM 5860 N VAL D 165 4.191 -37.766-35.873 1. 00 19.26 N
ATOM 5861 CA VAL D 165 4.491 -37.839 -37.298 1. 00 20.25 CATOM 5861 CA VAL D 165 4.491 -37.839 -37.298 1.00 20.25 C
ATOM 5862 CB VAL D 165 4.414 -39.284 —37.815 1. 00 18.59 CATOM 5862 CB VAL D 165 4.414 -39.284 --37.815 1.00 18.59 C
ATOM 5863 CG1 VAL D 165 4.632 - 39.299 -39.314 1. .00 17.87 CATOM 5863 CG1 VAL D 165 4.632-39.299 -39.314 1. .00 17.87 C
ATOM 5864 CG2 VAL D 165 5.452 - 40.141 -37.128 1. ,00 17.87 CATOM 5864 CG2 VAL D 165 5.452-40.141 -37.128 1., 00 17.87 C
ATOM 5865 C VAL D 165 3.546 -36.995 -38.148 1. ,00 21.77 CATOM 5865 C VAL D 165 3.546 -36.995 -38.148 1., 00 21.77 C
ATOM 5866 0 VAL D 165 2.332 -37.181 -38.107 1. ,00 22.38 0ATOM 5866 0 VAL D 165 2.332 -37.181 -38.107 1., 00 22.38 0
ATOM 5867 N LEU D 166 4.113 -36.081 -38.933 1. .00 21.57 NATOM 5867 N LEU D 166 4.113 -36.081 -38.933 1. .00 21.57 N
ATOM 5868 CA LEU D 166 3.327 -35.224 -39.816 1. ,00 22.25 CATOM 5868 CA LEU D 166 3.327 -35.224 -39.816 1., 00 22.25 C
ATOM 5869 CB LEU D 166 3.798 -33.769 -39.682 1, .00 20.22 CATOM 5869 CB LEU D 166 3.798 -33.769 -39.682 1, .00 20.22 C
ATOM 5870 CG LEU D 166 3.372 -32.936 -38.463 1, .00 20.93 CATOM 5870 CG LEU D 166 3.372 -32.936 -38.463 1, .00 20.93 C
ATOM 5871 CD1 LEU D 166 3.328 -33.776 -37.197 1, .00 18.89 CATOM 5871 CD1 LEU D 166 3.328 -33.776 -37.197 1, .00 18.89 C
ATOM 5872 CD2 LEU D 166 4.352 -31.764 - 38.310 1, .00 18.12 CATOM 5872 CD2 LEU D 166 4.352 -31.764-38.310 1, .00 18.12 C
ATOM 5873 C LEU D 166 3.452 - 35.675 -41.274 1, .00 21.83 GATOM 5873 C LEU D 166 3.452-35.675 -41.274 1, .00 21.83 G
ATOM 5874 0 LEU D 166 4.546 -35.693 - 41.837 1, .00 22.01 0ATOM 5874 0 LEU D 166 4.546 -35.693-41.837 1, .00 22.01 0
ATOM 5875 N VAL D 167 2.332 -36.025 -41.894 1 .00 22.32 NATOM 5875 N VAL D 167 2.332 -36.025 -41.894 1 .00 22.32 N
ATOM 5876 CA VAL D 167 2.372 -36.496 -43.270 1 .00 22.80 CATOM 5876 CA VAL D 167 2.372 -36.496 -43.270 1 .00 22.80 C
ATOM 5877 CB VAL D 167 2.094 - 38.022 -43.341 1 .00 23.72 CATOM 5877 CB VAL D 167 2.094-38.022 -43.341 1 .00 23.72 C
ATOM 5878 CG1 VAL D 167 0.612 -38.281 -43.345 1 ■ 00 23.15 CATOM 5878 CG1 VAL D 167 0.612 -38.281 -43.345 1 ∎ 00 23.15 C
ATOM 5879 CG2 VAL D 167 2.724 -38.612 -44.573 1 ■ 00 28.43 C ATOM 5880 C VAL D 167 1.333 -35.760 -44.106 1.00 21.78 CATOM 5879 CG2 VAL D 167 2.724 -38.612 -44.573 1 ∎ 00 28.43 C ATOM 5880 C VAL D 167 1.333 -35.760 -44.106 1.00 21.78 C
ATOM 5881 0 VAL D 167 0.317 - 35.309 -43.583 1. 00 23.86 0ATOM 5881 0 VAL D 167 0.317-35.309 -43.583 1.00 23.86 0
ATOM 5882 N LEU D 168 1.584 - 35.646 -45.405 1. 00 21. 15 NATOM 5882 N LEU D 168 1.584-35.646 -45.405 1. 00 21. 15 N
ATOM 5883 CA LEU D 168 0.642 -35.007 -46.316 1. 00 20.76 CATOM 5883 CA LEU D 168 0.642 -35.007 -46.316 1. 00 20.76 C
ATOM 5884 CB LEU D 168 -34.584 -47.605 1. 00 19.41 CATOM 5884 CB LEU D 168 -34.584 -47.605 1. 00 19.41 C
ATOM 5885 CG LEU D 168 -33.103 - 47.796 1. 00 19.14 CATOM 5885 CG LEU D 168 -33.103-47.796 1. 00 19.14 C
ATOM 5886 CD1 LEU D 168 2.073 -32.491 - 46. 483 1. 00 18.63 CATOM 5886 CD1 LEU D 168 2.073 -32.491-46. 483 1.00 18.63 C
ATOM 5887 CD2 LEU D 168 2.812 -32.955 - 48. 809 1. 00 16.60 CATOM 5887 CD2 LEU D 168 2.812 -32.955-48. 809 1.00 16.60 C
ATOM 5888 C LEU D 168 -0.510 -35.949 -46. 647 1. 00 22.43 CATOM 5888 C LEU D 168 -0.510 -35.949 -46. 647 1. 00 22.43 C
ATOM 5889 0 LEU D 168 - 35.565 -46. 579 1. 00 25.94 0ATOM 5889 0 LEU D 168-35.565 -46. 579 1. 00 25.94 0
ATOM 5890 N VAL D. 169 -0.190 -37.184 -47. 002 1. 00 22.72 NATOM 5890 N VAL D. 169 -0.190 -37.184 -47. 002 1. 00 22.72 N
ATOM 5891 CA VAL D 169 -1.225 -38.184 -47. 247 1. 00 25. 63 CATOM 5891 CA VAL D 169 -1.225 -38.184 -47. 247 1. 00 25. 63 C
ATOM 5892 CB VAL D 169 -1.489 -38.369 - 48. 763 1. 00 26. 41 CATOM 5892 CB VAL D 169 -1.489 -38.369-48. 763 1. 00 26. 41 C
ATOM 5893 CGI VAL D 169 -1.933 -37.054 - 49. 374 1. 00 26. 89 CATOM 5893 CGI VAL D 169 -1.933 -37.054-49. 374 1. 00 26. 89 C
ATOM 5894 CG2 VAL D 169 —0.238 -38.869一 49. 460 1. 00 26. 28 CATOM 5894 CG2 VAL D 169 —0.238 -38.869 One 49. 460 1. 00 26. 28 C
ATOM 5895 C VAL D 169 -0.826 -39.525 -46. 642 1. 00 25. 48 CATOM 5895 C VAL D 169 -0.826 -39.525 -46. 642 1. 00 25. 48 C
ATOM 5896 0 VAL D 169 0.357 -39.849 -46. 561 1. 00 25. 76 0ATOM 5896 0 VAL D 169 0.357 -39.849 -46. 561 1. 00 25. 76 0
ATOM 5897 N ALA D 170 - 1.818 -40.294 -46. 210 1. 00 27. 44 NATOM 5897 N ALA D 170-1.818 -40.294 -46. 210 1. 00 27. 44 N
ATOM 5898 CA ALA D 170 -1.570 -41 · 565 -45. 535 1. ,00 28. 36 CATOM 5898 CA ALA D 170 -1.570 -41565 -45.535 1., 00 28.36 C
ATOM 5899 CB ALA D 170 -1.739 -41 · 396 -44. 026 1. ,00 26. 28 CATOM 5899 CB ALA D 170 -1.739 -41 396 -44. 026 1., 00 26. 28 C
ATOM 5900 C ALA D 170 -2.518 -42.641 -46. 052 1. ,00 29. 54 CATOM 5900 C ALA D 170 -2.518 -42.641 -46. 052 1., 00 29. 54 C
ATOM 5901 0 ALA D 170 -3.713 - 42.398 -46. 220 1. ,00 30. 32 0ATOM 5901 0 ALA D 170 -3.713-42.398 -46. 220 1., 00 30. 32 0
ATOM 5902 N ALA D 171 -1.981 -43.827 -46.313 1. ,00 30. 59 NATOM 5902 N ALA D 171 -1.981 -43.827 -46.313 1., 00 30. 59 N
ATOM 5903 CA ALA D 171 -2.815 - 44.986 -46. 626 1. .00 32. 93 CATOM 5903 CA ALA D 171 -2.815-44.986 -46. 626 1. .00 32. 93 C
ATOM 5904 CB ALA D 171 -2.068 -45.949 -47. 553 1. .00 33. 42 CATOM 5904 CB ALA D 171 -2.068 -45.949 -47. 553 1. .00 33. 42 C
ATOM 5905 C ALA D 171 - 3.170 -45.688 -45. 324 1. .00 33. 48 CATOM 5905 C ALA D 171-3.170 -45.688 -45. 324 1. .00 33. 48 C
ATOM 5906 0 ALA D 171 - 2.349 -45.773 - 44. 408 1. .00 33. 80 0ATOM 5906 0 ALA D 171-2.349 -45.773-44. 408 1. .00 33. 80 0
ATOM 5907 N PRO D 172 -4.400 - 46.202 -45. 223 1, .00 34. 29 NATOM 5907 N PRO D 172 -4.400-46.202 -45. 223 1, .00 34. 29 N
ATOM 5908 CD PRO D 172 -5.501 -46.145 -46. 199 1, .00 34. 54 CATOM 5908 CD PRO D 172 -5.501 -46.145 -46. 199 1, .00 34. 54 C
ATO 5909 CA PRO D 172 -4.788 -46.854 -43. 970 1, .00 35. 84 GATO 5909 CA PRO D 172 -4.788 -46.854 -43. 970 1, .00 35. 84 G
ATOM 5910 CB PRO D 172 - 6.274 -47.181一 44. 169 1, .00 35. 61 CATOM 5910 CB PRO D 172-6.274 -47.181 1 44. 169 1, .00 35. 61 C
ATOM 5911 CG PRO D 172 - 6.507 - 47.097 -45. 635 1. .00 34. 63 CATOM 5911 CG PRO D 172-6.507-47.097 -45. 635 1. .00 34. 63 C
ATOM 5912 C PRO D 172 -3.936 -48.080 -43. 655 1, .00 37. 66 CATOM 5912 C PRO D 172 -3.936 -48.080 -43. 655 1, .00 37. 66 C
ATOM 5913 0 PRO D 172 -3.734 -48.422 -42. 487 1, .00 39. 42 0ATOM 5913 0 PRO D 172 -3.734 -48.422 -42. 487 1, .00 39. 42 0
ATOM 5914 N 6LU D 173 -3.419 -48.727 -44. 695 1 .00 38. 60 NATOM 5914 N 6LU D 173 -3.419 -48.727 -44. 695 1 .00 38. 60 N
ATOM 5915 CA GLU D 173 - 2.458 -49.807 -44. 505 1 • 00 39. 90 C ATOM 5916 GB GLU D 173 -1.963 -50.331 - 45.859 1.0042.98 CATOM 5915 CA GLU D 173-2.458 -49.807 -44. 505 1 • 00 39. 90 C ATOM 5916 GB GLU D 173 -1.963 -50.331-45.859 1.0042.98 C
ATOM 5917 CG GLU D 173 -2.963 -51.209 -46.603 1. 00 46.59 CATOM 5917 CG GLU D 173 -2.963 -51.209 -46.603 1.00 46.59 C
ATOM 5918 CD GLU D 173 -3.967 - 50.410 -47.418 1. 00 49.53 CATOM 5918 CD GLU D 173 -3.967-50.410 -47.418 1. 00 49.53 C
ATOM 5919 0E1 GLU D 173 -3.815 - 49.172 -47.514 1. 00 48.97 0ATOM 5919 0E1 GLU D 173 -3.815-49.172 -47.514 1.00 48.97 0
ATOM 5920 0E2 GLU D 173 -4.911 -51.026 -47.963 1. 00 51.33 0ATOM 5920 0E2 GLU D 173 -4.911 -51.026 -47.963 1.00 51.33 0
ATOM 5921 C GLU D 173 - 1.269 -49.320 -43.684 1. 00 38.42 CATOM 5921 C GLU D 173-1.269 -49.320 -43.684 1. 00 38.42 C
ATOM 5922 0 GLU D 173 -0.910 -49.911 -42.667 1. 00 37.90 0ATOM 5922 0 GLU D 173 -0.910 -49.911 -42.667 1.00 37.90 0
ATOM 5923 N GLY D 174 -0.659 -48.231 -44.134 1. 00 37.04 NATOM 5923 N GLY D 174 -0.659 -48.231 -44.134 1. 00 37.04 N
ATOM 5924 CA GLY D 174 0.501 -47.712 -43.440 1. 00 33.99 CATOM 5924 CA GLY D 174 0.501 -47.712 -43.440 1. 00 33.99 C
ATOM 5925 C GLY D 174 0.152 -47.197 -42.059 1. 00 31.01 CATOM 5925 C GLY D 174 0.152 -47.197 -42.059 1. 00 31.01 C
ATOM 5926 0 GLY D 174 0.979o t -47.250 1. 00 31.45 0ATOM 5926 0 GLY D 174 0.979o t -47.250 1. 00 31.45 0
ATO 5927 :N ILE D 175 -1.067 -46.702 -41.890 1. 00 28.50 NATO 5927: N ILE D 175 -1.067 -46.702 -41.890 1. 00 28.50 N
ATOM 5928 CA ILE D 175 -1.514 -46.266 -40.577 1. 00 31.04 CATOM 5928 CA ILE D 175 -1.514 -46.266 -40.577 1. 00 31.04 C
ATOM 5929 CB ILE D 175 - 2.889 -45.560 -40.640 1. 00 29.98 CATOM 5929 CB ILE D 175-2.889 -45.560 -40.640 1. 00 29.98 C
ATOM 5930 GG2 ILE D 175 -3.372 -45.251 -39.233 1. 00 27.35 GATOM 5930 GG2 ILE D 175 -3.372 -45.251 -39.233 1. 00 27.35 G
ATOM 5931 CG1 ILE D 175 -2.779 -44.272 -41.471 1. 00 29.39 CATOM 5931 CG1 ILE D 175 -2.779 -44.272 -41.471 1. 00 29.39 C
ATOM 5932 CD1 ILE D 175 -4.063 -43.471 -41.580 1. 00 26.10 CATOM 5932 CD1 ILE D 175 -4.063 -43.471 -41.580 1. 00 26.10 C
ATOM 5933 C ILE D 175 -1.616 - 47.461 - 39.636 1. ,00 32.92 CATOM 5933 C ILE D 175 -1.616-47.461-39.636 1., 00 32.92 C
ATOM 5934 0 ILE D 175 - 1.252 -47.370 -38.467 1. 00 34.78 0ATOM 5934 0 ILE D 175-1.252 -47.370 -38.467 1.00 34.78 0
ATOM 5935 N ALA D 176 -2.095 - 48.589 -40.150 1. ,00 33.89 NATOM 5935 N ALA D 176 -2.095-48.589 -40.150 1., 00 33.89 N
ATOM 5936 CA ALA D 176 -2.257 -49.778 -39.315 1. ,00 35.01 CATOM 5936 CA ALA D 176 -2.257 -49.778 -39.315 1., 00 35.01 C
ATOM 5937 GB ALA D 176 -2.925 -50.911 -40.110 1. .00 35.78 GATOM 5937 GB ALA D 176 -2.925 -50.911 -40.110 1. .00 35.78 G
ATOM 5938 C ALA D 176 -0.909 - 50.235 - 38.792 1. ,00 33.34 CATOM 5938 C ALA D 176 -0.909-50.235-38.792 1., 00 33.34 C
ATOM 5939 0 ALA D 176 -0.756 -50.509 -37.601 1. .00 35.11 0ATOM 5939 0 ALA D 176 -0.756 -50.509 -37.601 1. .00 35.11 0
ATOM 5940 N ALA D 177 0.067 -50.301 —39.691 1. .00 31.88 NATOM 5940 N ALA D 177 0.067 -50.301 —39.691 1. .00 31.88 N
ATOM 5941 CA ALA D 177 1.411 -50.728 -39.339 1, ,00 31.38 CATOM 5941 CA ALA D 177 1.411 -50.728 -39.339 1,, 00 31.38 C
ATOM 5942 CB ALA D 177 2.272 - 50.797 - 40.590 1. .00 27.44 CATOM 5942 CB ALA D 177 2.272-50.797-40.590 1. .00 27.44 C
ATOM 5943 C ALA D 177 2.044 -49.787 -38.314 1, .00 32.24 CATOM 5943 C ALA D 177 2.044 -49.787 -38.314 1, .00 32.24 C
ATOM 5944 0 ALA D 177 2.805 -50.220 -37.441 1, .00 33.10 0ATOM 5944 0 ALA D 177 2.805 -50.220 -37.441 1, .00 33.10 0
ATOM 5945 N LEU D 178 1.728 -48.497 -38.421 1. .00 33.25 NATOM 5945 N LEU D 178 1.728 -48.497 -38.421 1. .00 33.25 N
ATOM 5946 CA LEU D 178 2.260 -47.516 -37.485 1, .00 33.25 CATOM 5946 CA LEU D 178 2.260 -47.516 -37.485 1, .00 33.25 C
ATOM 5947 CB LEU D 178 1.901 -46.092 -37.930 1, .00 33.82 CATOM 5947 CB LEU D 178 1.901 -46.092 -37.930 1, .00 33.82 C
ATOM 5948 C6 LEU D 178 2.690 -44.950 -37.276 1 .00 35.09 CATOM 5948 C6 LEU D 178 2.690 -44.950 -37.276 1 .00 35.09 C
ATOM 5949 CD1 LEU D 178 2.446 -44.890 -35.785 1, .00 33.80 CATOM 5949 CD1 LEU D 178 2.446 -44.890 -35.785 1, .00 33.80 C
ATOM 5950 CD2 LEU D 178 4.162 -45.168 -37.534 1, .00 37.60 CATOM 5950 CD2 LEU D 178 4.162 -45.168 -37.534 1, .00 37.60 C
ATOM 5951 C LEU D 178 -47.787 -36.108 1 .00 32.52 C ATOM 5952 0 LEU D 178 2.391 - 47.857 -35.117 1.0033.07 0ATOM 5951 C LEU D 178 -47.787 -36.108 1 .00 32.52 C ATOM 5952 0 LEU D 178 2.391-47.857 -35.117 1.0033.07 0
ATOM 5953 N 6LU D 179 0.353一 47.943 -36.052 1. 00 32.42 NATOM 5953 N 6LU D 179 0.353 One 47.943 -36.052 1.00 32.42 N
ATOM 5954 CA GLU D 179 -0.320 -48.166 -34.780 1. 00 35. 29 CATOM 5954 CA GLU D 179 -0.320 -48.166 -34.780 1. 00 35. 29 C
ATOM 5955 CB GLU D 179 -1.836 -48.127 -34.968 1. 00 35. 03 CATOM 5955 CB GLU D 179 -1.836 -48.127 -34.968 1. 00 35. 03 C
ATOM 5956 C6 GLU D 179 -2.369 -46.766 -35.374 1. 00 34. 65 CATOM 5956 C6 GLU D 179 -2.369 -46.766 -35.374 1. 00 34. 65 C
ATOM 5957 CD GLU D 179 -3.883 -46.726 - 35.429 1. 00 39. 06 CATOM 5957 CD GLU D 179 -3.883 -46.726-35.429 1. 00 39. 06 C
ATOM 5958 0E1 GLU D 179 - 4.458 -47.241 -36.415 1. 00 40. 82 0ATOM 5958 0E1 GLU D 179-4.458 -47.241 -36.415 1. 00 40. 82 0
ATOM 5959 0E2 6LU D 179 -4.501 -46.180 -34.484 1. 00 39. 65 0ATOM 5959 0E2 6LU D 179 -4.501 -46.180 -34.484 1. 00 39. 65 0
ATOM 5960 C GLU D 179 0.096 - 49.497 -34.163 1. 00 36. 82 CATOM 5960 C GLU D 179 0.096-49.497 -34.163 1. 00 36. 82 C
ATOM 5961 0 GLU D 179 0,011 -49.677 - 32.952 1. 00 38. 90 0ATOM 5961 0 GLU D 179 0,011 -49.677-32.952 1. 00 38. 90 0
ATOM 5962 N LYS D 180 0.556 -50.423 -34.997 1. ,00 37. 09 NATOM 5962 N LYS D 180 0.556 -50.423 -34.997 1., 00 37. 09 N
ATOM 5963 CA LYS 0 180 0.991 ，51.725 -34.514 1. 00 38. 09 CATOM 5963 CA LYS 0 180 0.991, 51.725 -34.514 1. 00 38. 09 C
ATOM 5964 CB LYS 0 180 0.936 - 52.752 -35.650 1. 00 40. 39 CATOM 5964 CB LYS 0 180 0.936-52.752 -35.650 1. 00 40. 39 C
ATOM 5965 CG LYS D 180 1.433 -54.147一 35.276 1. ,00 41. 87 CATOM 5965 CG LYS D 180 1.433 -54.147 One 35.276 1., 00 41. 87 C
ATOM 5966 CD LYS D 180 0.926 -55.205 - 36.257 1. ,00 42. 83 CATOM 5966 CD LYS D 180 0.926 -55.205-36.257 1., 00 42. 83 C
ATOM 5967 CE LYS D 180 1.832 -56.438 -36.285 1. 00 44. 95 CATOM 5967 CE LYS D 180 1.832 -56.438 -36.285 1. 00 44. 95 C
ATOM 5968 NZ LYS D 180 2.264 -56.862 —34.922 1. ,00 43. 21 NATOM 5968 NZ LYS D 180 2.264 -56.862 —34.922 1., 00 43. 21 N
ATOM 5969 C LYS D 180 2.401 -51.665 -33.941 1. ,00 38. 83 CATOM 5969 C LYS D 180 2.401 -51.665 -33.941 1., 00 38. 83 C
ATOM 5970 0 LYS D 180 2.659 - 52.193 -32.861 1. ,00 41. 44 0ATOM 5970 0 LYS D 180 2.659-52.193 -32.861 1., 00 41. 44 0
ATOM 5971 N ALA D 181 3.313 -51.017 -34.659 1. ,00 36. 30 NATOM 5971 N ALA D 181 3.313 -51.017 -34.659 1., 00 36.30 N
ATOM 5972 CA ALA D 181 4.710 -50.978 - 34.242 1. ,00 34. 31 CATOM 5972 CA ALA D 181 4.710 -50.978-34.242 1., 00 34. 31 C
ATOM 5973 CB ALA D 181 5.598 -50.675 - 35.444 1. .00 35. 13 CATOM 5973 CB ALA D 181 5.598 -50.675-35.444 1. .00 35. 13 C
ATOM 5974 C ALA D 181 4.975 -49.965 -33.129 1. ,00 34. 46 CATOM 5974 C ALA D 181 4.975 -49.965 -33.129 1., 00 34. 46 C
ATOM 5975 0 ALA D 181 5.891 -50.143 -32.324 1. .00 31. 76 0ATOM 5975 0 ALA D 181 5.891 -50.143 -32.324 1. .00 31. 76 0
ATOM 5976 N HIS D 182 4.173 -48.901 -33.093 1. .00 34. 67 NATOM 5976 N HIS D 182 4.173 -48.901 -33.093 1. .00 34. 67 N
ATOM 5977 CA HIS D 182 4.395 -47.798 -32.164 1, .00 33. 82 CATOM 5977 CA HIS D 182 4.395 -47.798 -32.164 1, .00 33. 82 C
ATOM 5978 CB HIS D 182 5.305 -46.756 -32.811 1. ,00 30. 00 CATOM 5978 CB HIS D 182 5.305 -46.756 -32.811 1., 00 30.00 C
ATOM 5979 CG HIS D 182 6.633 -47.297 -33.241 1. .00 27. 5フ CATOM 5979 CG HIS D 182 6.633 -47.297 -33.241 1. .00 27. 5F C
ATOM 5980 CD2 HIS D 182 7.118 -47.599 -34.468 1, .00 25. 84 GATOM 5980 CD2 HIS D 182 7.118 -47.599 -34.468 1, .00 25. 84 G
ATO 5981 ND1 HIS D 182 7.648 -47.572 -32.349 1. .00 26. 06 NATO 5981 ND1 HIS D 182 7.648 -47.572 -32.349 1. .00 26. 06 N
ATOM 5982 CE1 HIS D 182 8.703 -48.016 -33.010 1. .00 23. 20 CATOM 5982 CE1 HIS D 182 8.703 -48.016 -33.010 1. .00 23. 20 C
ATOM 5983 NE2 HIS D 182 8.407 -48.040 -34.296 1, .00 25. 78 NATOM 5983 NE2 HIS D 182 8.407 -48.040 -34.296 1, .00 25. 78 N
ATOM 5984 C HIS D 182 3.078 -47.141 -31■ 747 1. • 00 36. 79 CATOM 5984 C HIS D 182 3.078 -47.141 -31 747 1. • 00 36. 79 C
ATOM 5985 0 HIS D 182 2.760 -46.015 -32.152 1. .00 39. 37 0ATOM 5985 0 HIS D 182 2.760 -46.015 -32.152 1. .00 39. 37 0
ATOM 5986 N PRO D 183 2.298 -47.836 -30.915 1, .00 36. 48 NATOM 5986 N PRO D 183 2.298 -47.836 -30.915 1, .00 36. 48 N
ATOM 5987 CD PRO D 183 2.637 -49.116 -30.266 1 • 00 36. 87 C S6T ATOM 5987 CD PRO D 183 2.637 -49.116 -30.266 1 • 00 36. 87 C S6T
0 L9 '6Z 00' ι 086 ■9ε- 386 'ζ.ε- 066 Ό- L 1 0 Π31 0 ΪΖ09 匪 V 0 L9 '6Z 00' ι 086 ■ 9ε- 386 'ζ.ε- 066 Ό- L 1 0 Π31 0 ΪΖ09 匪 V
0 9S'Z£ 00' ι OLZ ■6ε- 381 Ό - 391·■!· LSI G Π31 ZQO 09 W01V0 9S'Z £ 00 'ι OLZ ■ 6ε- 381 Ό-391
0 00' L S08 ·6ε- '6ε— Ldl a Π31 iQO L209 W01V0 00 'L S08 6ε-' 6ε— Ldl a Π31 iQO L209 W01V
0 6/.'ΐε 00' L ■6ε - 3917 Ofr- οιε Ό- L21 a Π31 90 0209 INOIV0 6 /. 'Ϊ́ε 00' L 6ε-3917 Ofr- οιε Ό- L21 a Π31 90 0209 INOIV
0 ΐΌ0 0ε 00 L 939 •LS- 68 Ofr- L65 Ό- G Π31 80 61-09 WO丄 V0 ΐΌ0 0ε 00 L 939LS-68 Ofr- L65 Ό- G Π31 80 61-09 WO 丄 V
0 00 ι 169 ■9ε- 003.6S - 0 - LSI G Π31 VO 8109 W01V0 00 ι 169 9ε- 003.6S-0-LSI G Π31 VO 8109 W01V
N 09'6Z 00' ι ZLZ ■ss- ZZ5 '6ε— 981 Ό- m a nョ Ί N ん 109 W01VN 09'6Z 00 'ι ZLZ ss- ZZ5' 6ε— 981 Ό- m a n Ί N 109 109 W01V
0 00' ι τη ε- 9S0 ·6ε- 996 Ί 921 a 0 9L09 W01V0 00 'ι τη ε- 9S0 6ε- 996 Ί 921 a 0 9L09 W01V
0 60 '6Z 00 ι ■^ε- m '6ε- m Ό 981 a me 0 9109 W01V0 60 '6Z 00 ι ^^-m' 6ε- m Ό 981 a me 0 9109 W01V
0 8ε·6ε 00 ,ι LZL οε- 9985ε- LY ·0 - 981 G ΠΊ9 30 109 W01V0 8ε ・ 6ε 00, ι LZL οε- 9985ε- LY 0-981 G ΠΊ9 30 109 W01V
0 80 'Lf 00 L 9S8 '63- LV 'ん ε— εζ.6-ι- 98 L a ΠΊ9 130 9109 1N01V0 80 'Lf 00 L 9S8 '63-LV' ε- εζ.6-ι- 98 L a ΠΊ9 130 9109 1N01V
0 .8 '8 00 ½fr ■οε- ½6 '9 - 868 Ό- 98 L a ΠΊ9 ao 21.09 W01V0 .8 '8 00 ½fr ■ οε- ½6' 9-868 Ό- 98 L a ΠΊ9 ao 21.09 W01V
0 zv '9ε 00 .1 188 'οε- νη 8ε- ZSI '0 - 981 a Π19 90 "09 W01V0 zv '9ε 00 .1 188' οε- νη 8ε- ZSI '0-981 a Π19 90 "09 W01V
0 68 εε 00 ι 82 ζζ- ζ.οε ·ο 981 a ΠΊ9 80 0L09 W01V0 68 εε 00 ι 82 ζζ- ζ.οεοο 981 a ΠΊ9 80 0L09 W01V
0 6ε 'οε 00 '1. S 6 ■ζε- m '6ε— IL90 98 L 0 Π19 VO 6009 W01V0 6ε 'οε 00' 1. S 6 ζε- m '6ε— IL90 98 L 0 Π19 VO 6009 W01V
N 6 "62 00 Ί οζ 2ε- ΖΪΖ Ofr - fr89■!■ 98 L G Π19 N 8009 W01VN 6 "62 00 Ί οζ 2ε- ΖΪΖ Ofr-fr89 ■! ■ 98 L G Π19 N 8009 W01V
0 98O 00 Ί 6 6 ζε- ΟΙΟΊ 921 G IVA 0 L009 W01V0 98O 00 Ί 6 6 ζε- ΟΙΟΊ 921 G IVA 0 L009 W01V
0 9Ζ.'62 00 ι m 'ζε - 66Ζ.Ί 981 G IVA 0 9009 W01V0 9Ζ.'62 00 ι m 'ζε-66Ζ.Ί 981 G IVA 0 9009 W01V
0 Ofr 'ΖΖ 00 L LZ6 ■ιε- S90 'Sfr- C83 '9 91 a IVA 290 9009 WOIV0 Ofr 'ΖΖ 00 L LZ6ιε- S90' Sfr- C83 '9 91 a IVA 290 9009 WOIV
0 98'ΐε 00 Ί Z 9 ■εε- £Z9'l - 62S "f 981 a IVA ΙΌΟ W09 WO丄 V0 98'ΐε 00 Ί Z 9 εε- £ Z9'l-62S "f 981 a IVA ΙΌΟ W09 WO 丄 V
0 ζε'ιε 00 Ί ·2ε- 829 LlO S8L a IVA go εοο9 WOIV0 ζε'ιε 00 Ί2ε-829 LlO S8L a IVA go εοο9 WOIV
0 00 Ί L19 st z - SL6'Z 981 a IVA VO Ζ009 1N01V0 00 Ί L19 st z-SL6'Z 981 a IVA VO Ζ009 1N01V
N ε9'εε 00 Ί 9SL 'οε— on 'sfr- 699 Z . 98 L a IVA N L009 WOiVN ε9'εε 00 Ί 9SL 'οε— on' sfr- 699 Z. 98 L a IVA N L009 WOiV
0 9L ·η 00 ■χ 98 '82- 021 PSl G dSV 0 0009 WOIV0 9Lη00 χ 98 '82-021 PSl G dSV 0 0009 WOIV
0 00 Ί SLf 62- LVi -£ - τ ni a dSV 0 6663 WOIV0 00 Ί SLf 62- LVi-£-τ ni a dSV 0 6663 WOIV
0 00 Ί LIO 63- ϋ/Ζ -gt- 888 'fr m Q dSV ZQO 8669 INOIV0 00 Ί LIO 63- ϋ / Ζ -gt- 888 'fr m Q dSV ZQO 8669 INOIV
0 00 Ί 801 'LZ- 019 S ni a dSV IQO Z.66S WOiV0 00 Ί 801 'LZ- 019 S ni a dSV IQO Z.66S WOiV
0 83 Ofr 00 'L fr88 'LZ- S89' 81 a dSV Ό0 966S WOIV0 83 Ofr 00 'L fr88' LZ- S89 '81 a dSV Ό0 966S WOIV
0 00 'L QVi'LZ- ん ss ·γν- ·ε 0 dSV ao S669 INOIV0 00 'L QVi'LZ- ss s γν- ε 0 dSV ao S669 INOIV
0 08 ε 00 Ί "83- 63 -n- 693 'Ζ a dSV VO 17669 WOIV0 08 ε 00 Ί "83- 63 -n- 693 'Ζ a dSV VO 17669 WOIV
N 90 00 Ί '63- 86S 'St'- 09ΐ 'τ ni a dSV N 66S WOIVN 90 00 Ί '63-86S 'St'- 09ΐ' τ ni a dSV N 66S WOIV
0 ん ε·5ε 00 "1 389 "62- Ό- εβι a 0 Z66S WOIV0 ε ・ 5ε 00 "1 389" 62- Ό- εβι a 0 Z66S WOIV
0 00 Ί VLL '62- L86 Ό S8L G o¾d 0 L669 WOIV0 00 Ί VLL '62-L86 Ό S8L G o¾d 0 L669 WOIV
0 09 '9S 00 •ι m '62- 392 '617- 0ん S SSI G OHd 90 066S WOIV0 09 '9S 00 • ι m '62-392' 617-0 0 S SSI G OHd 90 066S WOIV
0 00 Ί I "63- 60S '8 £8£ Ό SSI a ao 6869 WOIV0 00 Ί I "63-60S '8 £ 8 £ Ό SSI a ao 6869 WOIV
0 9S.9S 00 "1 689 OS- 998 'LV- 996 Ό S8l a OMd VO 8869 WOIV 0 9S.9S 00 "1 689 OS- 998 'LV- 996 Ό S8l a OMd VO 8869 WOIV
SSLU0/L00Zdt/L3d 0fi/.S0/600Z OAV 96T SSLU0 / L00Zdt / L3d 0fi / .S0 / 600Z OAV 96T
0 ε ' 00' L 289 zv- 99S 9ん 9 •9 - 26 L a 311 L90 6309 W01V 0 ε '00' L 289 zv- 99S 9 9 • 9-26 L a 311 L90 6309 W01V
0 92 'LZ 00' L ■n- 6Ζ9 LSI ■L- 261 a 311 ZQO 8909 W01V0 92 'LZ 00' L n- 6Ζ9 LSI L- 261 a 311 ZQO 8909 W01V
〇 u •9 00' L ne ε - 201 ' - 002 'L- 261 a 311 ao Z.S09 W01V〇 u • 9 00 'L ne ε-201'-002 'L- 261 a 311 ao Z.S09 W01V
0 'LZ 00' L 911 ■Sfr - 809 ■Ofr - 08S ■9- 261 a 3ΊΙ vo 9909 1N01V0 'LZ 00' L 911 ■ Sfr-809 ■ Ofr-08S ■ 9- 261 a 3ΊΙ vo 9909 1N01V
N εο "8Z 00' I no •Sfr- 8tO ■6ε - LIV '9- 26 L a 311 N SS09 鼠 VN εο "8Z 00 'I noSfr-8tO 6ε-LIV' 9- 26 L a 311 N SS09 鼠 V
0 66 'し τ 00 'L L 9 ■Q - 98L ■8ε - LZZ — 161 a M3S 0 S09 W01V0 66 'and τ 00' L L 9 ■ Q-98L ■ 8ε-LZZ — 161 a M3S 0 S09 W01V
0 ιζ LZ 00 L 6ZV •s - 91 ■8ε - 09ε •s- 161 a ョ s 0 £209 WO丄 V0 ιζ LZ 00 L 6ZV • s-91 ■ 8ε-09ε • s- 161 a o s 0 £ 209 WO 丄 V
0 so 00 - LZL ' — 80S ■/.ε- εん 9 .9 - 1.6 L a ms 90 3909 WO丄 V0 so 00-LZL '— 80S ■ / .ε-ε 9 .9-1.6 Lams 90 3909 WO 丄 V
0 08 ■ ζ 00 . 991 ■LV- LL2 ■9ε- 08ん ■S- a Mas ao LS09 wo丄 v0 08 ■ ζ 00 .991 ■ LV- LL2 ■ 9ε- 08 ■ S- a Mas ao LS09 wo 丄 v
0 68 ' 00 099 sv- ■9ε - 0S9 •S - a aas vo 0S09 隠 V0 68 '00 099 sv- ∎ 9ε-0S9 • S-a aas vo 0S09 Hidden V
N 90 'S3 00 I Oil 9ε- L29 "f- m a aョ s , N 61709 W01VN 90 'S3 00 I Oil 9ε- L29 "f-ma ao s, N 61709 W01V
0 £6 00 L 621 ε- ■g- 061 a V1V 0 8^09 WO丄 V0 £ 6 00 L 621 ε- g- 061 a V1V 0 8 ^ 09 WO 丄 V
0 01 '93 00 L & ■ffr- Ζ 9 ε- 098 061 G v，v 0 09 W01V0 01 '93 00 L & n ffr- Ζ 9 ε- 098 061 G v, v 0 09 W01V
0 68 'ΪΖ 00 Ί LZ0 ■εε - S00 ε- 061 a v，v ao 9f09 WOIV0 68 'ΪΖ 00 Ί LZ0 εε-S00 ε- 061 a v, v ao 9f09 WOIV
0 99 Ζ 00 L 1.69 ■n- 2 ■εε- LZL ■ε - 061 a V1V vo Sf09 1N01V0 99 Ζ 00 L 1.69 n-2 2 εε- LZL ε-061 a V1V vo Sf09 1N01V
N 98 τζ 00 L ZOL W9 0L8 τ- 061 a V1V N no9 WO丄 VN 98 τζ 00 L ZOL W9 0L8 τ- 061 a V1V N no9 WO 丄 V
0 LI '92 00 'L 6SO L01 m 681 a mi 0 ε 09 WO丄 V0 LI '92 00 'L 6SO L01 m 681 a mi 0 ε 09 WO 丄 V
D 83 ■vz 00 rL 989 ■z - Ζ Ζ 9ε- 191 τ - 681 a mi 0 09 W01VD 83 ■ vz 00 r L 989 ■ z-Ζ Ζ 9ε- 191 τ-681 a mi 0 09 W01V
0 26 •u 00 ■L 8^1 980 ·8ε - m τ - 681 a mi 290 L 09 IN01V0 26 • u 00 L 8 ^ 1 9808ε-m τ-681 a mi 290 L 09 IN01V
0 16 ■9Z 00 L Z 6 •ε 969 ■LZ- 88Z 'τ- 681 G yn丄 190 Ofr09 WOiV0 16 ■ 9Z 00 L Z 6 • ε 969 ■ LZ- 88Z 'τ- 681 G yn 丄 190 Ofr09 WOiV
0 'S3 00 Ί SIS ' - 399 in 'τ - 681 0 mi ao 6809 W01V0 'S3 00 SIS SIS'-399 in 'τ-681 0 mi ao 6809 W01V
0 Z '93 00 •L too 92Ζ ·9ε- •τ- 681 a mi vo 8S09 WOIV0 Z '93 00 • L too 92Ζ 9ε- • τ- 681 a mi vo 8S09 WOIV
N 8 'SZ 00 ■i 99S S9t •9S - 80ϋ •2 - 681 a N LS09 WO丄 VN 8 'SZ 00 i 99S S9t • 9S-80ϋ • 2-681 a N LS09 WO 丄 V
0 S9 '62 00 L 6 ε - 6ん 8 9ε- 900 Ό 881 a 0 9S09 WOIV0 S9 '62 00 L 6 ε-6 8 9ε- 900 Ό 881 a 0 9S09 WOIV
0 68 '92 .00 •L L^8 ■6ε- 600 '9ε- AO I 'ト 881 a y人丄 0' 9809 WOIV0 68 '92 .00 • L L ^ 8 6ε- 600 '9ε- AO I' G 881 a y People 0 '9809 WOIV
0 0 ■ζε 00 t 80S ε- 696 ■εε— 1^0 τ- 881 a y人丄 HO ^ ο9 WOIV0 0 ζε 00 t 80S ε- 696 εε— 1 ^ 0 τ- 881 a y 丄 HO ^ ο9 WOIV
0 OS ■6Z 00 ■L S 9 εε- ZZi ε- 9LL "1- 881 a y人丄 ZO εεοθ WOiV0 OS ■ 6Z 00 ■ L S 9 εε- ZZi ε-9LL "1- 881 a y People ZO εεοθ WOiV
0 IP '82 00 ■I LL9 ε- S69 ■εε- £69 'τ- 881 a y人丄 330 ΖΖ09 WOIV0 IP '82 00 ■ I LL9 ε- S69 ■ εε- £ 69 'τ- 881 a y People 丄 330 ΖΖ09 WOIV
0 09 '92 00 'L 6L6 ■ss - Ζ.98 ■εε- ΪΖ^ ζ- 881 a y人丄 ZQO ιεο9 WOIV0 09 '92 00 'L 6L6 ■ ss-Ζ.98 ■ εε- ΪΖ ^ ζ- 881 a y people y ZQO ιεο9 WOIV
0 29 '82 00 -L Ίτε- οεζ. 269 Ό - 88 L a y人丄 130 οεο9 WOIV0 29 '82 00 -L Ίτε- οεζ. 269 Ό-88 L a y human 丄 130 οεο9 WOIV
0 fO "92 00 'L L8C ■9ε- ε - οεε Ό- 881 a y人丄 IQO 6209 WOIV0 fO "92 00 'L L8C 9ε- ε-οεε Ό- 881 a y human 丄 IQO 6209 WOIV
0 68 'LZ 00 H E ·9ε- ε- 9SZ •ι- 881 a y人丄 90 8Ζ09 WOIV0 68 'LZ 00 H E 9ε- ε-9SZιι 881 a y 丄 90 8Ζ09 WOIV
0 S6 ' I 00 'L Z.08 ■LS- 6S6 Ό - 88 L a ao £209 WOIV0 S6 'I 00' L Z.08 LS-6S6 Ό-88 L a ao £ 209 WOIV
0 ' 96 'LZ 00 ■I L£Z ■8ε- Z.66 -9ε- 982 'ト 881 a y人丄 vo 9209 WOIV0 '96' LZ 00 ■ I L £ Z ■ 8ε- Z.66 -9ε- 982 'G 881 a y People vo 9209 WOIV
N £1 'LZ 00 'L OIL ■LZ- ^ιο ·ζ.ε- Ό- 881 a y人丄 N S209 WOIVN £ 1 'LZ 00' L OIL LZ- ^ ιο ζ.ε- Ό- 881 a y person 丄 N S209 WOIV
0 6 ■ιε 00 'L SV5 ■9ε— ζε6 ^ε- Ι· 'Ζ- L21 a Π3Τ 0 Z09 1N01V 0 6 ■ ιε 00 'L SV5 ■ 9ε— ζε6 ^ ε- Ι ·' Ζ- L21 a Π3Τ 0 Z09 1N01V
SSLlLO/LOOZdT/Ud 0CZ.S0/600i ΟΛ\ ATOM 6060 CD1 I LE D 192 -7. 334 -41. 188 - 41. 421 1. 00 21. 20 CSSLlLO / LOOZdT / Ud 0CZ.S0 / 600i ΟΛ \ ATOM 6060 CD1 I LE D 192 -7. 334 -41. 188-41. 421 1. 00 21. 20 C
ATOM 6061 C I LE D 192 - 7. 006 -40. 942 -46. 431 1. 00 26. 71 GATOM 6061 C I LE D 192-7. 006 -40. 942 -46. 431 1. 00 26. 71 G
ATOM 6062 0 I LE D 192 -8. 197 -40. 754 -46. 639 1. 00 27. 26 0ATOM 6062 0 I LE D 192 -8. 197 -40. 754 -46. 639 1. 00 27. 26 0
ATOM 6063 N ASP D 193 -6. 203 - 41. 500 -47. 327 1. 00 26. 79 NATOM 6063 N ASP D 193 -6. 203-41. 500 -47. 327 1. 00 26. 79 N
ATOM 6064 CA ASP D 193 -6. 692 -41. 834 -48. 653 1. 00 30. 29 CATOM 6064 CA ASP D 193 -6. 692 -41. 834 -48. 653 1. 00 30. 29 C
ATOM 6065 CB ASP D 193 -5. 576 -41. 630 -49. 681 1. 00 32. 13 CATOM 6065 CB ASP D 193 -5. 576 -41. 630 -49. 681 1. 00 32. 13 C
ATOM 6066 C6 ASP D 193 -5. 348 -40. 149 -50. 020 1. 00 35. 13 CATOM 6066 C6 ASP D 193 -5. 348 -40. 149 -50. 020 1. 00 35. 13 C
ATOM 6067 0D1 ASP D 193 -6. 000 -39. 280 - 49. 395 1. 00 33. 33 0ATOM 6067 0D1 ASP D 193 -6. 000 -39. 280-49. 395 1. 00 33. 33 0
ATOM 6068 0D2 ASP D 193 -4. 518 - 39. 858 -50. 916 1. 00 33. 00 0ATOM 6068 0D2 ASP D 193 -4. 518-39. 858 -50. 916 1. 00 33. 00 0
ATOM 6069 C ASP D 193 -7. 232 -43. 267 -48. 708 1. 00 32. 73 CATOM 6069 C ASP D 193 -7. 232 -43. 267 -48. 708 1. 00 32. 73 C
ATOM 6070 0 ASP D 193 - 7. 352 -43· 931 -47. 679 1. 00 30. 73 0ATOM 6070 0 ASP D 193-7. 352 -43 931 -47. 679 1. 00 30. 73 0
ATOM 6071 N GLN D 194 -7. 574 -43. 735 -49. 902 1. 00 34. 41 NATOM 6071 N GLN D 194 -7. 574 -43. 735 -49. 902 1. 00 34. 41 N
ATOM 6072 CA GLN D 194 -8. 290 -45. 000 -50. 045 1. 00 38. 52 CATOM 6072 CA GLN D 194 -8. 290 -45. 000 -50. 045 1. 00 38. 52 C
ATOM 6073 CB GLN D 194 -8. 845 -45. 119 -51. 461 1. 00 40. 20 CATOM 6073 CB GLN D 194 -8. 845 -45. 119 -51. 461 1. 00 40. 20 C
ATOM 6074 C6 GLN D 194 -9. 735 -43. 957 - 51. 865 1. 00 45. 58 CATOM 6074 C6 GLN D 194 -9. 735 -43. 957-51. 865 1. 00 45. 58 C
ATOM 6075 CD GLN D 194 -9. 904 -43. 849 -53. 369 1. 00 47. 22 CATOM 6075 CD GLN D 194 -9. 904 -43. 849 -53. 369 1. 00 47. 22 C
ATOM 6076 0E1 GLN D 194 -9. 054 -44. 309 -54. 136 1. 00 49. 50 0ATOM 6076 0E1 GLN D 194 -9. 054 -44. 309 -54. 136 1. 00 49. 50 0
ATOM 6077 NE2 GLN D 194 -11. 002 -43. 240 -53. 799 1. 00 46. 45 NATOM 6077 NE2 GLN D 194 -11. 002 -43. 240 -53. 799 1. 00 46. 45 N
ATOM 6078 C GLN D 194 - 7. 415 -46. 221 -49. 734 1. 00. 40. 52 CATOM 6078 C GLN D 194-7. 415 -46. 221 -49. 734 1. 00. 40. 52 C
ATOM 6079 0 GLN D 194 -7. 827 - 47. 128 -49. 008 1. 00 39. 32 0ATOM 6079 0 GLN D 194 -7. 827-47. 128 -49. 008 1. 00 39. 32 0
ATOM 6080 N GLY D 195 -6. 209 -46. 247 -50. 288 1. , 00 40. 30 NATOM 6080 N GLY D 195 -6. 209 -46. 247 -50. 288 1., 00 40. 30 N
ATOM 6081 GA 6LY D 195 5. 319 -47. 354 - 50. 005 1. . 00 41. 44 CATOM 6081 GA 6LY D 195 5. 319 -47. 354-50. 005 1.. 00 41. 44 C
ATOM 6082 C GLY D 195 -4. 210 -47. 466 -51. 027 1. 00 42. 11 CATOM 6082 C GLY D 195 -4. 210 -47. 466 -51. 027 1. 00 42. 11 C
ATOM 6083 0 GLY D 195 -4. 022 -46. 564 -51. 840 1. 00 42. 99 0ATOM 6083 0 GLY D 195 -4. 022 -46. 564 -51. 840 1. 00 42. 99 0
ATOM 6084 N LEU D 196 - 3. 473 - 48. 570 - 50. 988 1. . 00 42. 19 NATOM 6084 N LEU D 196-3. 473-48. 570-50. 988 1.. 00 42. 19 N
ATOM 6085 CA LEU D 196 -2. 348 -48. 764 -51. 893 1. . 00 43. 45 CATOM 6085 CA LEU D 196 -2. 348 -48. 764 -51. 893 1.. 00 43. 45 C
ATOM 6086 CB LEU D 196 -1. 230 -49. 519 -51. 180 1. , 00 40. 55 CATOM 6086 CB LEU D 196 -1. 230 -49. 519 -51. 180 1., 00 40. 55 C
ATOM 6087 CG LEU D 196 -0. 695 -48. 870 -49. 905 1. . 00 40. 14 CATOM 6087 CG LEU D 196 -0. 695 -48. 870 -49. 905 1.. 00 40. 14 C
ATOM 6088 GD1 LEU D 196 0. 221 -49. 848 -49. 189 1. . 00 37. 22 GATOM 6088 GD1 LEU D 196 0. 221 -49. 848 -49. 189 1.. 00 37. 22 G
ATOM 6089 GD2 LEU D 196 0. 047 -47. 580 -50. 249 1. , 00 36. 16 CATOM 6089 GD2 LEU D 196 0. 047 -47. 580 -50. 249 1., 00 36. 16 C
ATOM 6090 C LEU D 196 -2. 769 -49. 540 - 53. 133 1. , 00 45. 90 CATOM 6090 C LEU D 196 -2. 769 -49. 540-53. 133 1., 00 45. 90 C
ATOM 6091 0 LEU D 196 -3. 641 -50. 408 -53. 066 1. . 00 47. 12 0ATOM 6091 0 LEU D 196 -3. 641 -50. 408 -53. 066 1.. 00 47. 12 0
ATOM 6092 N ASM D 197 -2. 156 -49. 223 -54. 268 1 , . 00 47. 17 NATOM 6092 N ASM D 197 -2. 156 -49. 223 -54. 268 1,. 00 47. 17 N
ATOM 6093 CA ASN D 197 -2. 250 -50. 098 - 55. 422 1. . 00 49. 21 CATOM 6093 CA ASN D 197 -2. 250 -50. 098-55. 422 1.. 00 49. 21 C
ATOM 6094 CB ASN D 197 -2. 242 -49. 287 -56. 725 1. . 00 49. 41 CATOM 6094 CB ASN D 197 -2. 242 -49. 287 -56. 725 1.. 00 49. 41 C
ATOM 6095 C6 ASN D 197 -0. 886 -48. 664 -57. 035 1. . 00 49. 79 C ATOM 6096 0D1 ASN D 197 0.090 -48.842 -56.301 1.0048.80 0ATOM 6095 C6 ASN D 197 -0. 886 -48. 664 -57. 035 1.. 00 49. 79 C ATOM 6096 0D1 ASN D 197 0.090 -48.842 -56.301 1.0048.80 0
ATOM 6097 ND2 ASN D 197 -0.826 -47.925 - 58.137 1. 00 50.45 NATOM 6097 ND2 ASN D 197 -0.826 -47.925-58.137 1. 00 50.45 N
ATOM 6098 C ASN D 197 - 1.069 - 51. 065 - 55.379 1. 00 50.34 CATOM 6098 C ASN D 197-1.069-51. 065-55.379 1. 00 50.34 C
ATOM 6099 0 ASN D 197 -0.274 - 51. 039 -54.440 1. 00 49.35 0ATOM 6099 0 ASN D 197 -0.274-51. 039 -54.440 1. 00 49.35 0
ATOM 6100 N GLU D 198 -0.959 -51. 907 -56.401 1. 00 52.70 NATOM 6100 N GLU D 198 -0.959 -51.907 -56.401 1.00 52.70 N
ATOM 6101 CA GLU D 198 -0.006 - 53.014 -56.409 1. 00 53.46 CATOM 6101 CA GLU D 198 -0.006-53.014 -56.409 1. 00 53.46 C
ATOM 6102 CB GLU D 198 -0.147 -53.814 -57. 708 1. 00 55.37 CATOM 6102 CB GLU D 198 -0.147 -53.814 -57. 708 1. 00 55.37 C
ATOM 6103 GG GLU D 198 -1.585 -54.163 -58. 076 1. 00 57.35 CATOM 6103 GG GLU D 198 -1.585 -54.163 -58. 076 1. 00 57.35 C
ATOM 6104 CD GLU D 198 -2.386 - 52.943 -58. 505 1. 00 59.70 CATOM 6104 CD GLU D 198 -2.386-52.943 -58. 505 1. 00 59.70 C
ATOM 6105 0E1 GLU D 198 -1.787 -52. 005 -59. 081 1. 00 59. 96 0ATOM 6105 0E1 GLU D 198 -1.787 -52. 005 -59. 081 1. 00 59. 96 0
ATOM 6106 0E2 GLU D 198 -3.614 - 52. 920 -58. 263 1, 00 61. 89 0ATOM 6106 0E2 GLU D 198 -3.614-52. 920 -58. 263 1, 00 61. 89 0
ATOM 6107 G GLU D 198 1.441 -52. 563 -56. 244 1. 00 52. 86 CATOM 6107 G GLU D 198 1.441 -52. 563 -56. 244 1. 00 52. 86 C
ATOM 6108 0 GLU D 198 2.278 -53. 317 -55. 743 1. 00 53. 79 . 0ATOM 6108 0 GLU D 198 2.278 -53. 317 -55. 743 1. 00 53. 79. 0
ATOM 6109 N HIS D 199 1.742 -51. 338 - 56. 657 1. 00 51. 82 NATOM 6109 N HIS D 199 1.742 -51. 338-56. 657 1. 00 51. 82 N
ATOM 6110 GA HIS D 199 3.113 -50. 849 -56. 578 1. 00 51. 25 CATOM 6110 GA HIS D 199 3.113 -50. 849 -56. 578 1. 00 51. 25 C
ATOM 6111 CB HIS D 199 3.458 -50. 074 -57. 848 1. 00 54. 01 CATOM 6111 CB HIS D 199 3.458 -50. 074 -57. 848 1. 00 54. 01 C
ATOM 6112 CG HIS D 199 3.473 -50. 928 -59. 077 1. 00 56. 08 CATOM 6112 CG HIS D 199 3.473 -50. 928 -59. 077 1. 00 56. 08 C
ATOM 6113 CD2 HIS D 199 4.500 -51. 426 -59. 805 1. 00 55. 77 GATOM 6113 CD2 HIS D 199 4.500 -51. 426 -59. 805 1. 00 55. 77 G
ATOM 6114 ND1 HIS D 199 2.319 -51. 404 -59. 663 1. 00 55. 74 NATOM 6114 ND1 HIS D 199 2.319 -51.404 -59.663 1.00 55.74 N
ATOM 6115 CE1 HIS D 199 2.636 -52. 162 - 60· 698 1. 00 56. 27 CATOM 6115 CE1 HIS D 199 2.636 -52. 162-60 698 1. 00 56. 27 C
ATOM 6116 NE2 HIS D 199 3.952 -52. 192 -60. 805 1. ,00 57. 08 NATOM 6116 NE2 HIS D 199 3.952 -52. 192 -60. 805 1., 00 57. 08 N
ATOM 6117 C HIS D 199 3.384 -49. 995 -55. 342 1. .00 50. 47 CATOM 6117 C HIS D 199 3.384 -49. 995 -55. 342 1. .00 50. 47 C
ATOM 6118 0 HIS D 199 4.372 -49. 257 -55'.284 1. 00 49. 52 0ATOM 6118 0 HIS D 199 4.372 -49. 257 -55'.284 1. 00 49. 52 0
ATOM 6119 N GLY D 200 2.507 -50. 105 -54. 350 1. ,00 48. 65 NATOM 6119 N GLY D 200 2.507 -50. 105 -54. 350 1., 00 48. 65 N
ATOM 6120 CA GLY D 200 2.761 -49. 458 -53. 079 1. .00 47. 10 CATOM 6120 CA GLY D 200 2.761 -49. 458 -53. 079 1. .00 47. 10 C
ATOM 6121 C GLY D 200 2.534 -47. 962 -53. 138 1. ,00 45. 90 CATOM 6121 C GLY D 200 2.534 -47. 962 -53. 138 1., 00 45. 90 C
ATOM 6122 0 GLY D 200 2.963 -47. 228 -52. 248 1. .00 46. 66 .0ATOM 6122 0 GLY D 200 2.963 -47. 228 -52. 248 1. .00 46. 66 .0
ATOM 6123 N TYR D 201 1.861 -47. 506 -54. 190 1. ,00 45. 13 NATOM 6123 N TYR D 201 1.861 -47. 506 -54. 190 1., 00 45. 13 N
ATOM 6124 CA TYR D 201 1.498 -46. 097 -54. 307 1. .00 42. 65 CATOM 6124 CA TYR D 201 1.498 -46. 097 -54. 307 1. .00 42. 65 C
ATOM' 6125 CB TYR D 201 1.388 -45. 699 -55. 780 1. .00 44. 38 CATOM '6125 CB TYR D 201 1.388 -45. 699 -55. 780 1. .00 44. 38 C
ATOM 6126 CG TYR 0 201 2.705 -45. 287 -56. 401 1. ,00 47. 21 CATOM 6126 CG TYR 0 201 2.705 -45. 287 -56. 401 1., 00 47. 21 C
ATOM 6127 CD1 TYR D 201 3.069 -43. 946 -56. 482 1. .00 48. 00 GATOM 6127 CD1 TYR D 201 3.069 -43. 946 -56. 482 1. .00 48. 00 G
ATOM 6128 GE1 TYR D 201 4.272 -43. 567 -57. 046 1, .00 49. 32 CATOM 6128 GE1 TYR D 201 4.272 -43. 567 -57. 046 1, .00 49. 32 C
ATOM 6129 CD2 TYR D 201 3.584 -46. 236 ，56. 902 1. .00 47. 07 CATOM 6129 CD2 TYR D 201 3.584 -46. 236, 56. 902 1. .00 47. 07 C
ATOM 6130 CE2 TY D 201 4.786 -45. 868 - 57. 464 1, .00 49. 15 CATOM 6130 CE2 TY D 201 4.786 -45. 868-57. 464 1, .00 49. 15 C
ATOM 6131 CZ TYR D 201 5.128 -44.533 -57. 536 1. .00 49. 19 C ATOM 6132 OH TYR D 201 6.332 - 44.171 - 58.093 1.0048.54 0ATOM 6131 CZ TYR D 201 5.128 -44.533 -57. 536 1. .00 49. 19 C ATOM 6132 OH TYR D 201 6.332-44.171-58.093 1.0048.54 0
ATOM 6133 C TY D 201 0.184 45· 798 -53. 595 1. 00 39.80 CATOM 6133 C TY D 201 0.184 45 798 -53. 595 1. 00 39.80 C
ATOM 6134 0 TYR D 201 -0.821 -46.477 -53. 816 1. 00 39.69 0ATOM 6134 0 TYR D 201 -0.821 -46.477 -53. 816 1. 00 39.69 0
ATOM 6135 N ILE D 202 0.198 -44.781 -52. 737 1. 00 37.25 NATOM 6135 N ILE D 202 0.198 -44.781 -52. 737 1. 00 37.25 N
ATOM 6136 CA ILE D 202 - 1.025 -44.320 - 52. 093 1. 00 33.72 CATOM 6136 CA ILE D 202-1.025 -44.320-52. 093 1. 00 33.72 C
ATOM 6137 CB ILE D 202 -0.756 -43.136 -51. 140 1. 00 34.90 CATOM 6137 CB ILE D 202 -0.756 -43.136 -51. 140 1. 00 34.90 C
ATOM 6138 GG2 ILE D 202 -2.065 -42.653 - 50. 516 1. 00 32.37 CATOM 6138 GG2 ILE D 202 -2.065 -42.653-50. 516 1.00 32.37 C
ATOM 6139 C61 ILE D 202 0.221 -43.559 -50. 046 1. 00 35.21 CATOM 6139 C61 ILE D 202 0.221 -43.559 -50. 046 1. 00 35.21 C
ATOM 6140 CD1 ILE D 202 0.658 -42.416 -49. 140 1. 00 35.43 CATOM 6140 CD1 ILE D 202 0.658 -42.416 -49. 140 1. 00 35.43 C
ATOM 6141 C ILE D 202 -1.997 -43.867 -53. 172 1. 00 31.97 CATOM 6141 C ILE D 202 -1.997 -43.867 -53. 172 1. 00 31.97 C
ATOM 6142 0 ILE D 202 -1.628 - 43.145 -54. 094 1. 00 29.55 0ATOM 6142 0 ILE D 202 -1.628-43.145 -54. 094 1. 00 29.55 0
ATOM 6143 ILE D 203 -3.240 -44.310 - 53. 057 1. 00 30.75 NATOM 6143 ILE D 203 -3.240 -44.310-53. 057 1. 00 30.75 N
ATOM 6144 CA ILE D 203 -4.271 - 43.975 -54. 026 1. 00 30.90 CATOM 6144 CA ILE D 203 -4.271-43.975 -54. 026 1. 00 30.90 C
ATOM 6145 CB ILE D 203 -4.901 - 45.262 -54.624 1. 00 32.14 CATOM 6145 CB ILE D 203 -4.901-45.262 -54.624 1. 00 32.14 C
ATOM 6146 G62 ILE D 203 -6.106 -44.911 - 55. 480 1. 00 34.07 CATOM 6146 G62 ILE D 203 -6.106 -44.911-55. 480 1. 00 34.07 C
ATOM 6147 CG1 ILE D 203 -3.858 - 46.030 -55. 437 1. 00 33.27 CATOM 6147 CG1 ILE D 203 -3.858-46.030 -55. 437 1. 00 33.27 C
ATOM 6148 CD1 ILE D 203 -3.302 -45.250 -56. 611 1. 00 33.63 CATOM 6148 CD1 ILE D 203 -3.302 -45.250 -56. 611 1. 00 33.63 C
ATOM 6149 C ILE D 203 - 5· 340 -43.201 -53. 271 1. 00 29.93 CATOM 6149 C ILE D 203-5 340 -43.201 -53. 271 1. 00 29.93 C
ATOM 6150 0 ILE D 203 -5.784 - 43.636 -52. 216 1. 00 31.78 0ATOM 6150 0 ILE D 203 -5.784-43.636 -52. 216 1. 00 31.78 0
ATOM 6151 N PRO D 204 -5.751 -42.034 -53. 787 1. 00 29.52 NATOM 6151 N PRO D 204 -5.751 -42.034 -53. 787 1. 00 29.52 N
ATOM 6152 CD PRO D 204 -6.892 -41 · 295 -53. 218 1. ,00 30.13 CATOM 6152 CD PRO D 204 -6.892 -41 295 -53. 218 1., 00 30.13 C
ATOM 6153 CA PRO D 204 -5.205 -41.365 -54. 972 1. ,00 29.97 CATOM 6153 CA PRO D 204 -5.205 -41.365 -54. 972 1., 00 29.97 C
ATOM 6154 CB PRO D 204 -6.209 - 40.250 -55.250 1. 00 27.60 CATOM 6154 CB PRO D 204 -6.209-40.250 -55.250 1.00 27.60 C
ATOM 6155 C6 PRO D 204 -6.844 -39.982 -53. 939 1. ,00 28.05 CATOM 6155 C6 PRO D 204 -6.844 -39.982 -53. 939 1., 00 28.05 C
ATOM 6156 C PRO D 204 -3.777 -40.834 -54. 802 1. .00 31.07 CATOM 6156 C PRO D 204 -3.777 -40.834 -54. 802 1. .00 31.07 C
ATOM 6157 0 PRO D 204 -3.041 -40.703 -55. 781 1. ,00 30.17 0ATOM 6157 0 PRO D 204 -3.041 -40.703 -55. 781 1., 00 30.17 0
ATOM 6158 N GLY D 205 ^ -3.393 -40.527 -53. 566 1. ,00 31.79 .ATOM 6158 N GLY D 205 ^ -3.393 -40.527 -53. 566 1., 00 31.79.
ATOM 6159 CA GLY D 205 -2.014 -40.153 -53. 295 1. .00 31.40 CATOM 6159 CA GLY D 205 -2.014 -40.153 -53. 295 1. .00 31.40 C
ATOM 6160 C GLY D 205 -1.527 -38.931 - 54. 060 1. .00 31.87 CATOM 6160 C GLY D 205 -1.527 -38.931-54. 060 1. .00 31.87 C
ATOM 6161 0 GLY D 205 -2.318 -38.173 -54. 626 1. .00 34.26 0ATOM 6161 0 GLY D 205 -2.318 -38.173 -54. 626 1. .00 34.26 0
ATOM 6162 N LEU D 206 - 0.214 - 38.740 - 54. 072 1. .00 30.85 NATOM 6162 N LEU D 206-0.214-38.740-54. 072 1. .00 30.85 N
ATOM 6163 CA LEU D 206 0.399 -37.596 -54. 735 1. .00 30.54 CATOM 6163 CA LEU D 206 0.399 -37.596 -54. 735 1. .00 30.54 C
ATOM 6164 GB LEU D 206 -36.745 -53. 704 1. .00 28.60 CATOM 6164 GB LEU D 206 -36.745 -53. 704 1. .00 28.60 C
ATOM 6165 C6 LEU D 206 0.241 - 36.117 -52. 649 1. .00 29.89 CATOM 6165 C6 LEU D 206 0.241-36.117 -52. 649 1. .00 29.89 C
ATOM 6166 CD1 LEU D 206 1.062 -35.417 - 51. 582 1. .00 29.07 CATOM 6166 CD1 LEU D 206 1.062 -35.417-51. 582 1. .00 29.07 C
ATOM 6167 CD2 LEU D 206 -0.701 -35.140一 53. 336 1, .00 29.21 C ATOM 6168 C LEU 0 206 1. 356 - 38. 023 -55. 849 1. 00 30. 05 CATOM 6167 CD2 LEU D 206 -0.701 -35.140 One 53. 336 1, .00 29.21 C ATOM 6168 C LEU 0 206 1. 356-38. 023 -55. 849 1. 00 30. 05 C
ATOM 6169 0 LEU D 206 1. 896 -37. 187 -56. 567 1. 00 29. 47 0ATOM 6169 0 LEU D 206 1. 896 -37. 187 -56. 567 1. 00 29. 47 0
ATOM 6170 N GLY D 207 1. 568 -39. 326 - 55. 985 1. 00 30. 66 NATOM 6170 N GLY D 207 1. 568 -39. 326-55. 985 1. 00 30. 66 N
ATOM 6171 CA 6LY D 207 2. 541 -39. 810 -56. 944 1. 00 32. 25 GATOM 6171 CA 6LY D 207 2. 541 -39. 810 -56. 944 1. 00 32. 25 G
ATOM 6172 C GLY D 207 3. 949 -39. 722 - 56· 390 1. 00 32. 67 CATOM 6172 C GLY D 207 3. 949 -39. 722-56 390 1. 00 32. 67 C
ATOM 6173 0 GLY D 207 4. 181 -39. 989 -55. 209 1. 00 32. 84 0ATOM 6173 0 GLY D 207 4. 181 -39. 989 -55. 209 1. 00 32. 84 0
ATOM 6174 N ASP D 208 4. 897 -39. 341 -57. 236 1. 00 32. 50 NATOM 6174 N ASP D 208 4. 897 -39. 341 -57. 236 1. 00 32. 50 N
ATOM 6175 CA ASP D 208 6. 277 -39. 244 -56. 792 1. 00 33. 69 GATOM 6175 CA ASP D 208 6. 277 -39. 244 -56. 792 1. 00 33. 69 G
ATOM 6176 CB ASP D 208 7. 224 -39. 476 -57. 964 1. 00 36. 87 CATOM 6176 CB ASP D 208 7. 224 -39. 476 -57. 964 1. 00 36. 87 C
ATOM 6177 C6 ASP D 208 7. 488 -40. 940 -58. 199 1. 00 40. 85 CATOM 6177 C6 ASP D 208 7. 488 -40. 940 -58. 199 1. 00 40. 85 C
ATOM 6178 0D1 ASP D 208 6. 510 -41. 691 -58. 391 1. 00 43. 06 0ATOM 6178 0D1 ASP D 208 6. 510 -41. 691 -58. 391 1. 00 43. 06 0
ATOM 6179 0D2 ASP D 208 8. 670 -41. 342 -58. 182 1. 00 43. 42 0ATOM 6179 0D2 ASP D 208 8. 670 -41. 342 -58. 182 1. 00 43. 42 0
ATOM 6180 C ASP D 208 6. 581 -37. 910 -56. 136 1. 00 32. 31 . CATOM 6180 C ASP D 208 6. 581 -37. 910 -56. 136 1. 00 32. 31. C
ATOM 6181 0 ASP D 208 7. 108 - 36. 999 -56. 773 1 00 32. 11 0ATOM 6181 0 ASP D 208 7. 108-36. 999 -56. 773 1 00 32. 11 0
ATOM 6182 N ALA D 209 6. 263 -37. 813 -54. 852 1 00 31. 01 NATOM 6182 N ALA D 209 6. 263 -37. 813 -54. 852 1 00 31. 01 N
ATOM 6183 CA ALA D 209 6. 422 -36. 567 -54. 122 1. 00 31. 18 CATOM 6183 CA ALA D 209 6. 422 -36. 567 -54. 122 1. 00 31. 18 C
ATOM 6184 CB ALA D 209 5. 877 -36. 721 - 52. 703 1 00 32. 47 cATOM 6184 CB ALA D 209 5. 877 -36. 721-52. 703 1 00 32. 47 c
ATOM 6185 C ALA D 209 7. 881 -36. 120 -54. 083 1 00 300 0. 24 cATOM 6185 C ALA D 209 7. 881 -36. 120 -54. 083 1 00 300 0. 24 c
O C O C
ATOM 6186 0 ALA D 209 8. 175 - 34. 930 -54. 181 1 00 30. 330 0 0ATOM 6186 0 ALA D 209 8. 175-34. 930 -54. 181 1 00 30. 330 0 0
ATOM 6187 N GLY D 210 8. 794 - 37. 072 -53. 942 1 00 NATOM 6187 N GLY D 210 8. 794-37. 072 -53. 942 1 00 N
ATOM 6188 CA GLY D 210 10. 205 -36. 734 -54. 009 1 do 27. 97 CATOM 6188 CA GLY D 210 10. 205 -36. 734 -54. 009 1 do 27. 97 C
ATOM 6189 G GLY D 210 10. 600 - 35. 998 -55. 287 1 00 28. 23 GATOM 6189 G GLY D 210 10. 600-35. 998 -55. 287 1 00 28. 23 G
ATOM 6190 0 GLY D 210 11. 184 -34. 919 -55'. 228 1 00 30. 07 0ATOM 6190 0 GLY D 210 11. 184 -34. 919 -55 '. 228 1 00 30. 07 0
ATOM 6191 N ASP D 211 10. 290 -36. 574 -56. 443 1 00 28. 01 NATOM 6191 N ASP D 211 10. 290 -36. 574 -56. 443 1 00 28. 01 N
ATOM 6192 CA ASP D 211 10. 688 -35. 982 -57. 717 1 00 26. 59 CATOM 6192 CA ASP D 211 10. 688 -35. 982 -57. 717 1 00 26. 59 C
ATOM 6193 CB ASP D 211 10. 263 - 36. 874 -58. 887 1 00 25. 48 CATOM 6193 CB ASP D 211 10. 263-36. 874 -58. 887 1 00 25. 48 C
ATOM 6194 CG ASP D 211 11. 083 -38. 143 -58. 989 1 00 25. 99 CATOM 6194 CG ASP D 211 11. 083 -38. 143 -58. 989 1 00 25. 99 C
ATOM 6195 0D1 ASP D 211 12. 239 -38. 145 -58. 542 1 00 26. 32 0ATOM 6195 0D1 ASP D 211 12. 239 -38. 145 -58. 542 1 00 26. 32 0
ATOM 6196 0D2 ASP D 211 10. 569 -39. 144 - 59. 527 1 00 30. 05 0ATOM 6196 0D2 ASP D 211 10. 569 -39. 144-59. 527 1 00 30. 05 0
ATOM 6197 C ASP D 211 10. 045 -34. 610 -57. 891 1 00 28. 58 CATOM 6197 C ASP D 211 10. 045 -34. 610 -57. 891 1 00 28. 58 C
ATOM 6198 0 ASP D 211 10. 663 -33. 689 - 58. 433 1 00 25. 82 0ATOM 6198 0 ASP D 211 10. 663 -33. 689-58. 433 1 00 25. 82 0
ATOM 6199 N LYS D 212 8. 799 -34. 481 -57 433 1 00 26. 95 NATOM 6199 N LYS D 212 8. 799 -34. 481 -57 433 1 00 26. 95 N
ATOM 6200 CA LYS D 212 8. 058 - 33. 243 -57 609 1 00 27. 47 GATOM 6200 CA LYS D 212 8. 058-33. 243 -57 609 1 00 27. 47 G
ATOM 6201 CB LYS D 212 6. 562 -33. 477 -57 369 1 00 29. 83 CATOM 6201 CB LYS D 212 6. 562 -33. 477 -57 369 1 00 29. 83 C
ATOM 6202 C6 LYS D 212 5. 824 -34. 003 -58 589 1 00 34. 42 CATOM 6202 C6 LYS D 212 5. 824 -34. 003 -58 589 1 00 34. 42 C
ATOM 6203 CD LYS D 212 4. 367 -34. 319 -58 269 1 00 39. 40 C ATOM 6204 CE LYS D 212 3.561 - 34.542 -59.546 1.0041.30 CATOM 6203 CD LYS D 212 4. 367 -34. 319 -58 269 1 00 39. 40 C ATOM 6204 CE LYS D 212 3.561-34.542 -59.546 1.0041.30 C
ATOM 6205 NZ LYS D 212 2.267 -35.226 -59. 281 1. 00 43.44 NATOM 6205 NZ LYS D 212 2.267 -35.226 -59. 281 1. 00 43.44 N
ATOM 6206 C LYS D 212 8.550 -32.113 -56. 712 1. 00 25.70 GATOM 6206 C LYS D 212 8.550 -32.113 -56. 712 1. 00 25.70 G
ATOM 6207 0 LYS D 212 8.380 -30.949 -57. 043 1. 00 27.88 0ATOM 6207 0 LYS D 212 8.380 -30.949 -57. 043 1.00 27.88 0
ATOM 6208 N ILE D 213 9.149 -32.454 -55. 577 1. 00 25.52 NATOM 6208 N ILE D 213 9.149 -32.454 -55. 577 1. 00 25.52 N
ATOM 6209 CA ILE D 213 9.757 -31.459 -54. 702 1. 00 25.06 CATOM 6209 CA ILE D 213 9.757 -31.459 -54. 702 1.00 25.06 C
ATOM 6210 CB ILE D 213 9.842 - 31.963 - 53. 254 1. 00 24.35 CATOM 6210 CB ILE D 213 9.842-31.963-53. 254 1. 00 24.35 C
ATOM 6211 CG2 ILE D 213 10.672 -31.008 - 52. 412 1. 00 21.56 CATOM 6211 CG2 ILE D 213 10.672 -31.008-52. 412 1. 00 21.56 C
ATOM 6212 CG1 ILE D 213 8.445 -32.109 -52. 663 1. 00 25.97 CATOM 6212 CG1 ILE D 213 8.445 -32.109 -52. 663 1. 00 25.97 C
ATOM 6213 CD1 ILE D 213 8.445 - 32.765 -51. 287 1. 00 26.73 CATOM 6213 CD1 ILE D 213 8.445-32.765 -51. 287 1. 00 26.73 C
ATOM 6214 C ILE D 213 11.171 -31.088 -55. 160 1. 00 26.79 CATOM 6214 C ILE D 213 11.171 -31.088 -55. 160 1. 00 26.79 C
ATOM 6215 .0 ILE D 213 11.610 -29.951 -54. 984 1. 00 26.03 0ATOM 6215 .0 ILE D 213 11.610 -29.951 -54. 984 1. 00 26.03 0
ATOM 6216 N PHE D 214 11.887 - 32.047 -55. 744 1. 00 26.28 . NATOM 6216 N PHE D 214 11.887-32.047 -55. 744 1. 00 26.28 .N
ATOM 6217 CA PHE D 214 13.275 - 31.805 -56. 141 1. 00 27.96 CATOM 6217 CA PHE D 214 13.275-31.805 -56. 141 1. 00 27.96 C
ATOM 6218 CB PHE D 214 14.149 - 32.992 -55. 724 1. 00 23.59 GATOM 6218 CB PHE D 214 14.149-32.992 -55. 724 1. 00 23.59 G
ATOM 6219 CG PHE D 214 14.421 -33.032 —54. 253 1. 00 24.81 CATOM 6219 CG PHE D 214 14.421 -33.032 —54. 253 1. 00 24.81 C
ATOM 6220 CD1 PHE D 214 15.650 - 32.644 - 53. 749 1. 00 23.86 CATOM 6220 CD1 PHE D 214 15.650-32.644-53. 749 1. 00 23.86 C
ATOM 6221 CD2 PHE D 214 13.433 - 33.425 -53. 363 1. ,00 25.24 CATOM 6221 CD2 PHE D 214 13.433-33.425 -53. 363 1., 00 25.24 C
ATOM 6222 CE1 PHE D 214 15.887 -32.645 -52. 385 1. ,00 .23.52 CATOM 6222 CE1 PHE D 214 15.887 -32.645 -52. 385 1., 00 .23.52 C
ATOM 6223 CE2 PHE D 214 13.668 -33.427 -51. 999 1. 00 23.18 CATOM 6223 CE2 PHE D 214 13.668 -33.427 -51. 999 1. 00 23.18 C
ATOM 6224 CZ PHE D 214 14.901 - 33.035 -51. 512 1. ,00 23.72 CATOM 6224 CZ PHE D 214 14.901-33.035 -51. 512 1., 00 23.72 C
ATOM 6225 C PHE D 214 13.437 -31.513 -57. 630 1. ,00 27.73 CATOM 6225 C PHE D 214 13.437 -31.513 -57. 630 1., 00 27.73 C
ATOM 6226 0 PHE D 214 14.511 -31.113 -58.090 1. ,00 28.62 0ATOM 6226 0 PHE D 214 14.511 -31.113 -58.090 1., 00 28.62 0
ATOM 6227 N GLY D 215 12.359 -31.700 - 58. 377 1. ,00 29.67 NATOM 6227 N GLY D 215 12.359 -31.700-58. 377 1., 00 29.67 N
ATOM 6228 CA GLY D 215 12.387 -31.406 -59. 795 1. .00 31.98 CATOM 6228 CA GLY D 215 12.387 -31.406 -59. 795 1. .00 31.98 C
ATOM 6229 G GLY D 215 13.189 - 32.444 -60. 549 1. .00 33.46 GATOM 6229 G GLY D 215 13.189-32.444 -60. 549 1. .00 33.46 G
ATOM 6230 0 GLY D 215 13.664 - 32.190 -61. 649 1. .00 34.10 0ATOM 6230 0 GLY D 215 13.664-32.190 -61. 649 1. .00 34.10 0
ATOM 6231 N THR D 216 13.341 - 33.620 -59. 954 1. .00 34.91 NATOM 6231 N THR D 216 13.341-33.620 -59. 954 1. .00 34.91 N
ATOM 6232 CA THR D 216 14.194 -34.645 -60. 524 1. .00 37.28 CATOM 6232 CA THR D 216 14.194 -34.645 -60. 524 1. .00 37.28 C
ATOM 6233 CB THR D 216 14.918 -35.443 -59. 410 1, .00 34.95 CATOM 6233 CB THR D 216 14.918 -35.443 -59. 410 1, .00 34.95 C
ATOM 6234 0G1 THR D 216 13.961 - 35.939 -58. 460 1. ■ 00. 31.90 0ATOM 6234 0G1 THR D 216 13.961-35.939 -58. 460 1. ■ 00. 31.90 0
ATOM 6235 CG2 THR D 216 15.932 - 34.555 -58. 701 1, .00 30.72 CATOM 6235 CG2 THR D 216 15.932-34.555 -58. 701 1, .00 30.72 C
ATOM 6236 C THR 0 216 13.412 -35.604 -61. 413 1, .00 41.14 CATOM 6236 C THR 0 216 13.412 -35.604 -61. 413 1, .00 41.14 C
ATOM 6237 0 THR D 216 12.875 -36.599 -60. 940 1, .00 41.53 0ATOM 6237 0 THR D 216 12.875 -36.599 -60. 940 1, .00 41.53 0
ATOM 6238 N LYS D 217 13.359 - 35.299 -62. 707 1, .00 46.25 NATOM 6238 N LYS D 217 13.359-35.299 -62. 707 1, .00 46.25 N
ATOM 6239 CA LYS D 217 12.661 -36.151 一 63, 672 1, .00 50.37 C zoz ATOM 6239 CA LYS D 217 12.661 -36.151 One 63, 672 1, .00 50.37 C zoz
0 S6 Ζ 00 "L 989 ■9 ZIZ '63- ん 08 'ΐε- LOOLX dIO 90 9Z.29 IN01V 0 S6 Ζ 00 "L 989 9 9 ZIZ '63-'08' ΐε- LOOLX dIO 90 9Z.29 IN01V
0 ½ '92 00 ,1 029 •L P '63- 990 'ιε- LOO IX dlD 90 tLZ9 WOIV0 ½ '92 00, 1 029L P '63-990 'ιε- LOO IX dlD 90 tLZ9 WOIV
0 LL 'LI 00 •I S98 "8 828 '62- 90 ■ιε- LOOLX dlD SO ZLZ2 WOIV0 LL 'LI 00 • I S98 "8 828 '62-90
N 88 •LI 00 ■i 9 ■6 186 '63- 8S9 ■ζε- LOOLX dlD ん N ZLZ9 IN01VN 88 • LI 00 ■ i 9 ■ 6 186 '63 -8S9 ■ ζε-LOOLX dlD N ZLZ9 IN01V
0 ■62 00 'I OOL ■OL SOS 'οε- 09ε ' - LOOLX d!9 80 ILZ9 WOIV0 ■ 62 00 'I OOL ■ OL SOS' οε- 09ε '-LOOLX d! 9 80 ILZ9 WOIV
N οε ■n 00 ■L IS6 •01 6LS ■οε- S66 'οε— LOOLX d!9 6N 0LZ9 WOIVN οε n 00 ■ L IS6 • 01 6LS ■ οε- S66 'οε— LOOLX d! 9 6N 0LZ9 WOIV
0 so 00 l LSZ ■31 UL 'οε- 'οε- tooix dlD *L0 6929 WOIV0 so 00 l LSZ 31 UL 'οε-' οε- tooix dlD * L0 6929 WOIV
0 Ofr ■LI? 00 "L 938 ■ει 996 ■83- LOL 'οε- LOOLX dl9 *Z0 8939 WOIV0 Ofr ■ LI? 00 "L 938 ■ ει 996 ■ 83- LOL 'οε- LOOLX dl9 * Z0 8939 WOIV
0 Sfr 00 "L OL ει 882 ■οε- 0L0 'ΐε- 100 IX d!9 *Z L9Z9 WOIV0 Sfr 00 "L OL ει 882 οε- 0L0 'ΐε- 100 IX d! 9 * Z L9Z9 WOIV
0 l£ ■St 00 "L OLl εζβ ■οε - LSS '62- too IX dlD *εο 9929 WOIV0 l £ ■ St 00 "L OLl εζβ ■ οε-LSS '62-too IX dlD * εο 9929 WOIV
0 zz ■Sir 00 'L 319 - 692 -ιε- L19 οε- 100 LX d丄 9 *εο 9929 WOIV0 zzSir 00 'L 319-692 -ιε- L19 οε- 100 LX d 丄 9 * εο 9929 WOIV
0 99 00 "L 90S on Ζ£- οε- WOLX d丄 9 *w fr929 WOIV0 99 00 "L 90S on Ζ £-οε- WOLX d 丄 9 * w fr929 WOIV
0 V6 'L 00 'L Z.69 TL 893 τε- ζη •οε- 瞧 X d丄 9 S9Z9 WOIV0 V6 'L 00' L Z.69 TL 893 τε- ζη οε- 瞧 X d 丄 9 S9Z9 WOIV
0 £9 00 Ί 8SS ■εε - 100 IX did *so WOIV0 £ 9 00 Ί 8SS εε-100 IX did * so WOIV
0 99 Ί9 00 -L ,SL 998 ■ζε- •12- 100 LX dl9 *90 1929 WOIV0 99 Ί9 00 -L, SL 998 ζε- • 12- 100 LX dl9 * 90 1929 WOIV
0 'OL 00 "L S83 •£l IZ6 ■^ε- - LOOLX d丄 9 V20 0929 WOIV0 'OL 00 "L S83 • £ l IZ6 ■ ^ ε--LOOLX d 丄 9 V20 0929 WOIV
0 L5 •89 00 ■I 391 ■zv 369 τζ- 219 'f8- 100LX d丄 9 VIO 6S39 WOIV d •89 00 -L 98S ■ει on •εε- ε- 100 IX dl9 Vd 8S39 WOIV0 L5 • 89 00 ■ I 391 ■ zv 369 τζ-219 'f8- 100LX d 丄 9 VIO 6S39 WOIV d • 89 00 -L 98S ■ ει on • εε- ε- 100 IX dl9 Vd 8S39 WOIV
0 I ' L 00 -L 699 810 ■εε - 9ΖΖ ·9ε- 隠 X d上 9 νεο £929 WOIV0 I 'L 00 -L 699 810 εε-9 ΖΖ 9ε- concealed X d 9 νεο £ 929 WOIV
0 90 ■6L 00 ■I εζζ ■si 699 ■οε- εοο '9ε- 隱 X d!9 930 9329 WOIV0 90 ■ 6L 00 ■ I εζζ ■ si 699 ■ οε- εοο '9ε- 隱 X d! 9 930 9329 WOIV
0 L6 ■ L 00 "l 009 .91· ££Z Ζ£- Ζ09 '9ε- 隠 X d丄 9 aw 59Z9 WOIV d 90 •6Z. 00 L £SL -SL 166 'ΐε- 812 9ε- LOO IX dlD Sd 1N01V0 L6 ■ L 00 "l 009 .91 · ££ Z Ζ £-Ζ09 '9ε- Hidden X d 丄 9 aw 59Z9 WOIV d 90 • 6Z. Sd 1N01V
0 n •08 00 l 99 ■91 LQ9 ζ- 66 •εε - 1.00 IX d丄 9 aeo ε939 WOIV0 n • 08 00 l 99 ■ 91 LQ9 ζ-66 • εε-1.00 IX d 丄 9 aeo ε939 WOIV
0 ιε '28 00 'L €VL 'Li . l£Z 18 τε- 隱 X d丄 9 9εο 2929 WOIV0 ιε '28 00 'L € VL' Li .l £ Z 18 τε- 隱 X d 丄 9 9εο 2929 WOIV
0 . ο '18 00 'L ιο ■91 8ん 6 ε- 966 • ε- . 隠 X' dlD 920 LS39 WOIV0. Ο '18 00 'L ιο ■ 91 8 6 ε- 966 • ε-. Hidden X' dlD 920 LS39 WOIV
0 99 "28 00 'L V6Z '81 5LZ ε- 108 ' ε- 赚 X dI9 910 0929 WOIV d 61 8 00 Ί 681 ■a 090 ■^ε- 86乙 ■εε- 隱 X d!9 9d 61729 WOIV0 99 "28 00 'L V6Z '81 5LZ ε- 108' ε- 赚 X dI9 910 0929 WOIV d 61 8 00 Ί 681 ■ a 090 ■ ^ ε- 86 B ■ εε- 隱 X d! 9 9d 61729 WOIV
Liz α S人"! 8f39 yョ丄Liz α S people "! 8f39 y 丄
0 6ε "99 00 Ί ε 6 ■S9 - 880 ■ζ.ε- 88f •0L Liz α S人つ 1X0 LVZ9 WOIV0 6ε "99 00 Ί ε 6 ■ S9-880 ■ ζ.ε- 88f • 0L Liz α S person 1X0 LVZ9 WOIV
0 L9 '29 00 '!· '29- .9tr ■SS- 90 •0L LIZ 0 S人 1 0 WOIV0 L9 '29 00 '! · '29-.9tr ■ SS- 90 • 0L LIZ 0 S 1 1 WOIV
0 '23 00 "I βεε ■S9- BSZ "9ε- εん L •u LIZ 0 S人 Ί 0 2fZ9 WOIV0 '23 00 "I βεε ■ S9- BSZ" 9ε-εN L u u LIZ 0 S Ί 0 2fZ9 WOIV
N 10 '9S 00 "I 6 'ん 9- ISP ·8ε- 368 •01 LIZ 0 S人， ZN m9 WOIVN 10 '9S 00 "I 6' 9- ISP · 8ε- 368 • 01 LIZ 0 S people, ZN m9 WOIV
0 L9 '99 00 "L 'ん 9 - 100 -8ε- εβο •31 Liz a SAl 30 WOIV0 L9 '99 00 "L '9-100 -8ε- εβο • 31 Liz a SAl 30 WOIV
0 81 ■SS 00 •L 8S乙 ■39- ■βε- 090 '21 Liz a SAl ao 21739 WOIV0 81 ■ SS 00 • L 8S B ■ 39- ■ βε- 090 '21 Liz a SAl ao 21739 WOIV
0 OL S 00 Ί wo •S9- 181 ■8ε- 60t^ τι LIZ Q SAl DO WOIV0 OL S 00 Ί wo • S9- 181 8ε-60 t ^ τι LIZ Q SAl DO WOIV
0 LL 'LB 00 l 6 9 'C9- S99 ■ζ.ε- S92 LIZ 0 Ski ao 0PZ9 WOIV 0 LL 'LB 00 l 6 9' C9- S99 ζ.ε- S92 LIZ 0 Ski ao 0PZ9 WOIV
^LlL0/L00Zdr/13d 0 " 0/600Z OAV ATOM 6276 N1 GTP X1001 -29, 659 -29.428 7.303 1.00 25.76 N^ LlL0 / L00Zdr / 13d 0 "0 / 600Z OAV ATOM 6276 N1 GTP X1001 -29, 659 -29.428 7.303 1.00 25.76 N
ATOM 6277 C2 GTP X麵 -28. 709 -29.702 8.294 1. 00 25.79 CATOM 6277 C2 GTP X 麵 -28. 709 -29.702 8.294 1. 00 25.79 C
ATOM 6278 N2 GTP X1001 -27. 422 -29.618 7.918 1. 00 21.11 NATOM 6278 N2 GTP X1001 -27. 422 -29.618 7.918 1.00 21.11 N
ATOM 6279 N3 GTP X1001 -29. 025 -30.029 9.548 1. 00 26.76 NATOM 6279 N3 GTP X1001 -29. 025 -30.029 9.548 1. 00 26.76 N
ATOM 6280 C4 GTP X1001 -30. 383 -30.075 9.767 1. 00 29.27 CATOM 6280 C4 GTP X1001 -30. 383 -30.075 9.767 1. 00 29.27 C
ATOM 6281 PG GTP XI 002 -15. 549 -29.005 -22.765 1. 00 81.38 PATOM 6281 PG GTP XI 002 -15. 549 -29.005 -22.765 1.00 81.38 P
ATOM 6282 01 G GTP X1002 -14.737 -29.517 -23.929 1. 00 80.44 0ATOM 6282 01 G GTP X1002 -14.737 -29.517 -23.929 1.00 80.44 0
ATOM 6283 02G GTP X1002 -16.659 - 29.936 -22.352 1. 00 80.13 0ATOM 6283 02G GTP X1002 -16.659-29.936 -22.352 1.00 80.13 0
ATOM 6284 03G GTP X1002 -16.131 -27.633 -23.111 1. 00 80.30 0ATOM 6284 03G GTP X1002 -16.131 -27.633 -23.111 1.00 80.30 0
ATOM 6285 Q3B GTP X1002 -14.554 - 28.872 -21.522 1. 00 76.67 0ATOM 6285 Q3B GTP X1002 -14.554-28.872 -21.522 1. 00 76.67 0
ATOM 6286 PB GTP X1002 -14.3.54 -29.919 -20.307 1. 00 71.97 PATOM 6286 PB GTP X1002 -14.3.54 -29.919 -20.307 1.00 71.97 P
ATOM .6287 01B GTP X1002 -14.808 - 31.272 20.737 1. 00 70.24 0ATOM .6287 01B GTP X1002 -14.808-31.272 20.737 1.00 70.24 0
ATOM 6288 02B GTP X1002 -13.077 - 29.828 - 19.622 1. 00 70.65 0ATOM 6288 02B GTP X1002 -13.077-29.828-19.622 1. 00 70.65 0
ATOM 6289 03A GTP X1002 -15. 466 - 29.417 -19.289 1. 00 66.00 0ATOM 6289 03A GTP X1002 -15. 466-29.417 -19.289 1. 00 66.00 0
ATOM 6290 PA GTP X1002 -16. 867 - 30.000 -18.697 1. 00 59.93 PATOM 6290 PA GTP X1002 -16. 867-30.000 -18.697 1. 00 59.93 P
ATOM 6291 01 A GTP X1002 -17. 662 - 28.832 -18.189 1. 00 62.54 0ATOM 6291 01 A GTP X1002 -17. 662-28.832 -18.189 1.00 62.54 0
ATOM 6292 02A GTP X1002 -17. 492 - 30.987 -19.578 1. 00 61.10 0ATOM 6292 02A GTP X1002 -17. 492-30.987 -19.578 1. 00 61.10 0
ATOM 6293 05* GTP X1002 -16. 285 - 30.770 - 17.439 1, 00 56.16 0ATOM 6293 05 * GTP X1002 -16. 285-30.770-17.439 1, 00 56.16 0
ATOM 6294 C5* GTP X1002 -15. 625 -32.029 -17.542 1. ,00. 45.91 CATOM 6294 C5 * GTP X1002 -15. 625 -32.029 -17.542 1., 00. 45.91 C
ATOM 6295 C4* GTP X1002 -16. 091 - 32.947 -16.435 1. ,00 41.61 CATOM 6295 C4 * GTP X1002 -16. 091-32.947 -16.435 1., 00 41.61 C
ATOM 6296 04* 6TP X1002 -17. 092 - 32.306 -15.581 1. 00 38.65 0ATOM 6296 04 * 6TP X1002 -17. 092-32.306 -15.581 1.00 38.65 0
ATOM 6297 C3* GTP X1002 - 16. 735 - 34.255 -16.942 1. ,00 39.40 CATOM 6297 C3 * GTP X1002-16. 735-34.255 -16.942 1., 00 39.40 C
ATOM 6298 03* GTP X1002 -16. 068 -35.380 -16.363 1. ,00 40.26 0ATOM 6298 03 * GTP X1002 -16. 068 -35.380 -16.363 1., 00 40.26 0
ATOM 6299 C2* GTP X1002 -18. 186 - 34.114 -16.542 1. .00 37.97 CATOM 6299 C2 * GTP X1002 -18. 186-34.114 -16.542 1. .00 37.97 C
ATOM 6300 02* GTP X1002 -18. 740 -35.385 -16.171 1. .00 38.46 0ATOM 6300 02 * GTP X1002 -18. 740 -35.385 -16.171 1. .00 38.46 0
ATOM 6301 Ci* GTP X1002 -18. 166 - 33.224 -15.353 1. .00 37.02 CATOM 6301 Ci * GTP X1002 -18. 166-33.224 -15.353 1. .00 37.02 C
ATOM 6302 N9 GTP X 002 -19. 385 -32.427 - 15.129 1. .00 33.01 . NATOM 6302 N9 GTP X 002 -19. 385 -32.427-15.129 1. .00 33.01 .N
ATOM 6303 C8 GTP X1002 -19. 885 -31.415 - 15.930 1. .00 30.16 CATOM 6303 C8 GTP X1002 -19. 885 -31.415-15.930 1. .00 30.16 C
ATOM 6304 N7 GTP X1002 - 20. 987 -30.890 -15.471 1, .00 29.53 NATOM 6304 N7 GTP X1002-20. 987 -30.890 -15.471 1, .00 29.53 N
ATOM 6305 C5 GTP X1002 -21. 239 -31.589 -14.298 1, .00 29.66 GATOM 6305 C5 GTP X1002 -21. 239 -31.589 -14.298 1, .00 29.66 G
ATOM 6306 C6 GTP X1002 -22. 304 -31.476 -13.341 1. .00 27.59 CATOM 6306 C6 GTP X1002 -22. 304 -31.476 -13.341 1. .00 27.59 C
ATOM 6307 06 GTP X1002 -23. 264 -30.717 -13.335 1, .00 28.77 0ATOM 6307 06 GTP X1002 -23. 264 -30.717 -13.335 1, .00 28.77 0
ATOM 6308 N1 GTP X1002 -22. 174 -32.394 -12.276 1, .00 29.09 NATOM 6308 N1 GTP X1002 -22. 174 -32.394 -12.276 1, .00 29.09 N
ATOM 6309 C2 GTP X1002 -21. 129 -33.315 -12.160 1, .00 29.94 CATOM 6309 C2 GTP X1002 -21. 129 -33.315 -12.160 1, .00 29.94 C
ATOM 6310 N2 GTP XI 002 -21. 167 -34.109 -11.086 1 .00 27.81 NATOM 6310 N2 GTP XI 002 -21. 167 -34.109 -11.086 1 .00 27.81 N
ATOM 6311 N3 GTP XI 002 -20. 140 -33.426 -13.044 1, .00 29.75 N ATOM 6312 C4 GTP X1002 - 20.253 -32.538 -14.084 1.00 30.83 CATOM 6311 N3 GTP XI 002 -20. 140 -33.426 -13.044 1, .00 29.75 N ATOM 6312 C4 GTP X1002-20.253 -32.538 -14.084 1.00 30.83 C
ATOM 6313 PG GTP X1003 17.472 -18.959 -23.992 1. 00 69.80 PATOM 6313 PG GTP X1003 17.472 -18.959 -23.992 1. 00 69.80 P
ATOM 6314 01 G GTP X1003 18.304 -17.943 -23.233 1. 00 68.82 0ATOM 6314 01 G GTP X1003 18.304 -17.943 -23.233 1. 00 68.82 0
ATOM 6315 02G GTP X1003 17.617 - 20.375 -23.470 1. 00 68.91 0ATOM 6315 02G GTP X1003 17.617-20.375 -23.470 1. 00 68.91 0
ATOM 6316 036 GTP X1003 16.034 -18.533 -24.172 1. 00 70.27 0ATOM 6316 036 GTP X1003 16.034 -18.533 -24.172 1.00 70.27 0
ATOM 6317 03B GTP X1003 18.129 -19.001 -25.444 1. 00 66.16 0ATOM 6317 03B GTP X1003 18.129 -19.001 -25.444 1. 00 66.16 0
ATOM 6318 PB GTP X1003 17.765 -18.077 -26.707 1. 00 62.60 PATOM 6318 PB GTP X1003 17.765 -18.077 -26.707 1. 00 62.60 P
ATOM 6319 01 B GTP X1003 18.706 -18.370 - 27.809 1. 00 62.97 0ATOM 6319 01 B GTP X1003 18.706 -18.370-27.809 1.00 62.97 0
ATOM 6320 02B GTP XI 003 17.694 -16.654 - 26.335 1. 00 62.12 0ATOM 6320 02B GTP XI 003 17.694 -16.654-26.335 1. 00 62.12 0
ATOM 6321 03A GTP X1003 16.325 -18.596 -27.146 1. 00 58.58 0ATOM 6321 03A GTP X1003 16.325 -18.596 -27.146 1. 00 58.58 0
ATOM 6322 PA GTP X1003 15.715 -19.443 - 28.390 1. 00 52.83 PATOM 6322 PA GTP X1003 15.715 -19.443-28.390 1. 00 52.83 P
ATOM 6323 01 A GTP X1003 14.500 -20.145 -27.886 1. 00 54.29 0ATOM 6323 01 A GTP X1003 14.500 -20.145 -27.886 1. 00 54.29 0
ATOM 6324 02A GTP X1003 16.778 -20.284 - 28.994 1. 00 53.60 . 0ATOM 6324 02A GTP X1003 16.778 -20.284-28.994 1.00 53.60 .0
ATOM 6325 05* GTP X1003 15.306 -18.270 -29.375 1. 00 48.83 0ATOM 6325 05 * GTP X1003 15.306 -18.270 -29.375 1. 00 48.83 0
ATOM 6326 C5* 6TP X1003 16.244 - 17.615 -30.229 1, .00 42.84 CATOM 6326 C5 * 6TP X1003 16.244-17.615 -30.229 1, .00 42.84 C
ATOM 6327 C4* GTP X1003 15.662 -16.294 -30, 687 1. 00 39.69 CATOM 6327 C4 * GTP X1003 15.662 -16.294 -30, 687 1. 00 39.69 C
ATOM 6328 04* GTP X1003 14.424 -16.498 -31.453 1. ,00 37.59 0ATOM 6328 04 * GTP X1003 14.424 -16.498 -31.453 1., 00 37.59 0
ATOM 6329 C3* GTP XI 003 15.282 - 15.354 -29.538 1. ,00 39.75 CATOM 6329 C3 * GTP XI 003 15.282-15.354 -29.538 1., 00 39.75 C
ATOM 6330 03* GTP X1003 15.623 -14.003 -29.865 1. .00 41.84 0ATOM 6330 03 * GTP X1003 15.623 -14.003 -29.865 1. .00 41.84 0
ATOM 6331 C2* GTP XI 003 13.811 - 15.612 - 29.388 1. .00 38.66 CATOM 6331 C2 * GTP XI 003 13.811-15.612-29.388 1. .00 38.66 C
ATOM 6332 02* GTP XI 003 13.166 -14.496 -28.772 1. .00 41.02 0ATOM 6332 02 * GTP XI 003 13.166 -14.496 -28.772 1. .00 41.02 0
ATOM 6333 C1* GTP X1003 13.336 -15.815 -30.804 1, .00 37.23 CATOM 6333 C1 * GTP X1003 13.336 -15.815 -30.804 1, .00 37.23 C
ATOM 6334 ΝΘ GTP X1003 2.127 -16.670 -30.986 1. ,00 33.80 NATOM 6334 ΝΘ GTP X1003 2.127 -16.670 -30.986 1., 00 33.80 N
ATOM 6335 C8 GTP XI 003 11.743 -17.740 -30.200 1. .00 30.29 CATOM 6335 C8 GTP XI 003 11.743 -17.740 -30.200 1. .00 30.29 C
ATOM 6336 N7 GTP X1003 10.634 -18.304 -30.584 1. .00 31.85 NATOM 6336 N7 GTP X1003 10.634 -18.304 -30.584 1. .00 31.85 N
ATOM 6337 C5 GTP X1003 10.241 -17.574 -31.695 1, .00 30.11 CATOM 6337 C5 GTP X1003 10.241 -17.574 -31.695 1, .00 30.11 C
ATOM 6338 G6 GTP XI 003 9.094一 17.705 -32.555 1. .00 29.10 CATOM 6338 G6 GTP XI 003 9.094 One 17.705 -32.555 1. .00 29.10 C
ATOM 6339 06 GTP X1003 8.167 -18.515 - 32.505 1, .00 26.04 0ATOM 6339 06 GTP X1003 8.167 -18.515-32.505 1, .00 26.04 0
ATOM 6340 N1 GTP X1003 9.080 -16.740 -33.590 1 • 00 28.55 NATOM 6340 N1 GTP X1003 9.080 -16.740 -33.590 1 • 00 28.55 N
ATOM 6341 C2 GTP X1003 10.064 -15.767 -33.759 1 .00 30.00 CATOM 6341 C2 GTP X1003 10.064 -15.767 -33.759 1 .00 30.00 C
ATOM 6342 N2 GTP X1003 9.890 -14.935 -34.800 1 • 0033.21 NATOM 6342 N2 GTP X1003 9.890 -14.935 -34.800 1 • 0033.21 N
ATOM 6343 N3 GTP XI 003 11.123 - 15.637 -32.964 1 .0029.40 NATOM 6343 N3 GTP XI 003 11.123-15.637 -32.964 1 .0029.40 N
ATOM 6344 C4 GTP X1003 一 16.565 -31.955 1 .00 31.93 CATOM 6344 C4 GTP X1003 One 16.565 -31.955 1 .00 31.93 C
ATOM 6345 PG GTP X1004 - 7.083 -16.406 -60.660 1 ■ 0080.95 PATOM 6345 PG GTP X1004-7.083 -16.406 -60.660 1 ∎ 0080.95 P
ATOM 6346 01 G GTP XI 004 -8.583 - 16.269 -60.717 1 .00 80.40 0ATOM 6346 01 G GTP XI 004 -8.583-16.269 -60.717 1 .00 80.40 0
ATOM 6347 02G 6TP X1004 一 6.495 -16.013一 59.331 1 .00 80.31 0 ATOM 6348 03G GTP X1004 一 6.450 -15.566 -61.771 1.0080.50 0ATOM 6347 02G 6TP X1004 One 6.495 -16.013 One 59.331 1 .00 80.31 0 ATOM 6348 03G GTP X1004 One 6.450 -15.566 -61.771 1.0080.50 0
ATOM 6349 03B GTP X1004 -6. 742 -17.949 -60.890 1. 00 75.94 0ATOM 6349 03B GTP X1004 -6. 742 -17.949 -60.890 1. 00 75.94 0
ATOM 6350 PB GTP X1004 - 7. 576 -19.225 -60.357 1. 00 71.98 ΡATOM 6350 PB GTP X1004-7. 576 -19.225 -60.357 1. 00 71.98 Ρ
ATOM 6351 01 B GTP X1004 - 8. 981 -19.140 -60.846 1. 00 72.26 0ATOM 6351 01 B GTP X1004-8. 981 -19.140 -60.846 1. 00 72.26 0
ATOM 6352 02B GTP X1004 -6. 896 -20.500 -60.490 1. 00 71.83 0ATOM 6352 02B GTP X1004 -6. 896 -20.500 -60.490 1. 00 71.83 0
ATOM 6353 03A GTP X10Q4 - 7. 662 -18.901 -58.802 1. 00 68.24 0ATOM 6353 03A GTP X10Q4-7. 662 -18.901 -58.802 1.00 68.24 0
ATOM 6354 PA GTP X1004 -6. 638 -18.907 -57. 545 1. 00 62.07 ΡATOM 6354 PA GTP X1004 -6. 638 -18.907 -57. 545 1. 00 62.07 Ρ
ATOM 6355 01 A GTP X1004 -7. 194 -19.850 -56. 532 1. 00 65.19 0ATOM 6355 01 A GTP X1004 -7. 194 -19.850 -56. 532 1. 00 65.19 0
ATOM 6356 02A GTP X1004 -6. 385 - 17.515 -57. 102 1. 00 62.22 0ATOM 6356 02A GTP X1004 -6. 385-17.515 -57. 102 1. 00 62.22 0
ATOM 6357 05* GTP X1004 -5. 341 -19.524 - 58. 220 1. 00 57.26 0ATOM 6357 05 * GTP X1004 -5. 341 -19.524-58. 220 1. 00 57.26 0
ATOM 6358. C5* GTP X1004 -4. 259 - 18.718 -58. 700 1. 00 49.41 CATOM 6358. C5 * GTP X1004 -4. 259-18.718 -58. 700 1. 00 49.41 C
ATOM 6359 • C4* GTP X1004 -2. 939 - 19.284 -58. 218 1. 00 45.21 CATOM 6359 • C4 * GTP X1004 -2. 939-19.284 -58. 218 1. 00 45.21 C
ATOM 6360 04* GTP X1004 -2. 880 - 19.297 -56. 763 1. 00 41.74 . 0ATOM 6360 04 * GTP X1004 -2. 880-19.297 -56. 763 1. 00 41.74. 0
ATOM 6361 C3* GTP X1004 -2. 661 -20.734 -58. 670 1. 00 45.55 CATOM 6361 C3 * GTP X1004 -2. 661 -20.734 -58. 670 1.00 45.55 C
ATOM 6362 03* GTP X1004 - 1· 428 - 20.792 -59. 393 1. 00 46.71 0ATOM 6362 03 * GTP X1004-1 428-20.792 -59. 393 1. 00 46.71 0
ATOM 6363 C2* GTP X1004 - 2. 668 -21.527 -57. 377 1. 00 43.22 CATOM 6363 C2 * GTP X1004-2. 668 -21.527 -57. 377 1. 00 43.22 C
ATOM 6364 02* GTP X1004 - 1. 654 -22.538 -57. 413 1. 00 46.97 0ATOM 6364 02 * GTP X1004-1. 654 -22.538 -57. 413 1. 00 46.97 0
ATOM 6365 C1* GTP X1004 -2. 338 -20.540 -56. 315 1. 00 39.58 CATOM 6365 C1 * GTP X1004 -2. 338 -20.540 -56. 315 1.00 39.58 C
ATOM 6366 N9 GTP X1004 -2. 925 -20.777 -54. 989 1. ,00 33.03 ΝATOM 6366 N9 GTP X1004 -2. 925 -20.777 -54. 989 1., 00 33.03 Ν
ATOM 6367 C8 GTP X1004 -4.273 - 20.761 -54. 664 1. 00 30.52 CATOM 6367 C8 GTP X1004 -4.273-20.761 -54. 664 1.00 30.52 C
ATOM 6368 N7 GTP X1004 -4.510 -21.000 -53. 402 1. ,00 28.84 ΝATOM 6368 N7 GTP X1004 -4.510 -21.000 -53. 402 1., 00 28.84 Ν
ATOM 6369 C5 GTP X1004 3· 249 -21.188 -52. 848 1. ,00 27.96 GATOM 6369 C5 GTP X1004 3-249 -21.188 -52. 848 1., 00 27.96 G
ATOM 6370 C6 GTP X1004 -2.844 -21.482 -51'.505 1. 00 25.82 CATOM 6370 C6 GTP X1004 -2.844 -21.482 -51'.505 1. 00 25.82 C
ATOM 6371 06 GTP X1004 -3.537 -21.642 - 50. 499 1. .00 25.62 0ATOM 6371 06 GTP X1004 -3.537 -21.642-50. 499 1. .00 25.62 0
ATOM 6372 N1 GTP X1004 -1. 437 -21.594 -51, 377 1. .00 27.09 ΝATOM 6372 N1 GTP X1004 -1. 437 -21.594 -51, 377 1. .00 27.09 Ν
ATOM 6373 C2 GTP X1004 - 0. 540 -21.439 -52. 428 1, .00 25.07 CATOM 6373 C2 GTP X1004-0. 540 -21.439 -52. 428 1, .00 25.07 C
ATOM 6374 N2 GTP X1004 0. 755 -21.585 - 52. 114 1. ,00 26.71 ΝATOM 6374 N2 GTP X1004 0. 755 -21.585-52. 114 1., 00 26.71 Ν
ATOM 6375 N3 GTP X1004 - 0. 907 -21.165 -53. 677 1. .00 25.98 ΝATOM 6375 N3 GTP X1004-0. 907 -21.165 -53. 677 1. .00 25.98 Ν
ATOM 6376 C4 GTP X1004 - 2. 266 -21.053 - 53. 824 1, .00 29.50 CATOM 6376 C4 GTP X1004-2. 266 -21.053-53. 824 1, .00 29.50 C
TER · 637フ GTP X1004 TER 637 GTP X1004
ATOM 6378 0 HOH 2001 -22. 415 -5.089 3. 466 1, ■ 0023.41 0 ATOM 6378 0 HOH 2001 -22. 415 -5.089 3. 466 1, ∎ 0023.41 0
ATOM 6379 0 HOH 2002 -9. 099 1.125 -30. 689 1, ■ 0026.09 0ATOM 6379 0 HOH 2002 -9. 099 1.125 -30. 689 1, ■ 0026.09 0
ATOM 6380 0 HOH 2003 12. 025 -12.481 - 36. 367 1, .0037.58 0ATOM 6380 0 HOH 2003 12. 025 -12.481-36. 367 1, .0037.58 0
ATOM 6381 0 HOH 2004 17. 384 -34.811 -55, 776 1 .00 19.28 0ATOM 6381 0 HOH 2004 17. 384 -34.811 -55, 776 1 .00 19.28 0
ATOM 6382 0 HOH 2005 6. 286 -45.644 - 46. 511 1, .0025.81 0ATOM 6382 0 HOH 2005 6. 286 -45.644-46. 511 1, .0025.81 0
ATOM 6383 0 HOH 2006 22. ,365 -38.733 -46. ,655 1 .00 22.18 0 ATOM 6384 0 HOH 2007 - 26.906 - 9.680 11.952 1.00 21.97ATOM 6383 0 HOH 2006 22., 365 -38.733 -46., 655 1 .00 22.18 0 ATOM 6384 0 HOH 2007-26.906-9.680 11.952 1.00 21.97
ATOM 6385 0 ' HOH 2008 -8.722 0.561 -49.669 1. 00 22.89ATOM 6385 0 'HOH 2008 -8.722 0.561 -49.669 1.00 22.89
ATOM 6386 0 HOH 2009 -13.991 -10.603 6.608 1. 00 28.34ATOM 6386 0 HOH 2009 -13.991 -10.603 6.608 1. 00 28.34
ATOM 6387 0 HOH 2010 2.101 -15.234 -23.319 1. 00 22.58ATOM 6387 0 HOH 2010 2.101 -15.234 -23.319 1. 00 22.58
ATOM 6388 0 HOH 2011 8.398 -39.927 -53.111 1. 00 42.41ATOM 6388 0 HOH 2011 8.398 -39.927 -53.111 1.00 42.41
ATOM 6389 0 HOH 2012 -29.897 -24.273 14.909 1. 00 25.43ATOM 6389 0 HOH 2012 -29.897 -24.273 14.909 1. 00 25.43
ATOM 6390 0 HOH 2013 - 22, 978 -13.130 16.233 1. 00 22.07ATOM 6390 0 HOH 2013-22, 978 -13.130 16.233 1. 00 22.07
ATOM 6391 0 HOH 2014 -22.601 -5.987 0.424 1. 00 26.28ATOM 6391 0 HOH 2014 -22.601 -5.987 0.424 1. 00 26.28
ATOM 6392 0 HOH 2015 16.861 -41.460 -50.147 1. 00 37.45ATOM 6392 0 HOH 2015 16.861 -41.460 -50.147 1. 00 37.45
ATOM 6393 0 HOH 2016 -11.394 -2.342 - 20.808 1. 00 34.14ATOM 6393 0 HOH 2016 -11.394 -2.342-20.808 1. 00 34.14
ATOM 6394 0 HOH 2017 7.044 -44.335 -43.628 1. 00 28.16ATOM 6394 0 HOH 2017 7.044 -44.335 -43.628 1.00 28.16
ATOM 6395 0 HOH 2018 . 11.877 -20.818 -27.904 1. 00 31.88ATOM 6395 0 HOH 2018. 11.877 -20.818 -27.904 1. 00 31.88
ATOM 6396 0 HOH 2019 -4.260 -25.335 - 27.798 1. 00 30.90ATOM 6396 0 HOH 2019 -4.260 -25.335-27.798 1. 00 30.90
ATOM 6397 0 HOH 2020 - 16.493 -18.193 - 16.306 1, 00 28.11ATOM 6397 0 HOH 2020-16.493 -18.193-16.306 1, 00 28.11
ATOM 6398 0 HOH 2021 0.428 4.402 - 35.358 1. ,00 35.82ATOM 6398 0 HOH 2021 0.428 4.402-35.358 1., 00 35.82
ATOM 6399 0 画 2022 11.007 -39.157 -47.761 1. 00 25.77ATOM 6399 0 Stroke 2022 11.007 -39.157 -47.761 1.00 25.77
ATOM 6400 0 HOH 2023 -6.029 - 20, 636 -49.548 1. .00 30.75ATOM 6400 0 HOH 2023 -6.029-20, 636 -49.548 1. .00 30.75
ATOM 6401 0 HOH 2024 -33.177 -47.407 - 20.804 1. 00 44.76ATOM 6401 0 HOH 2024 -33.177 -47.407-20.804 1. 00 44.76
ATOM 6402 0 HOH 2025 -40.507 -49.881 - 14.657 1. ,00 42.41ATOM 6402 0 HOH 2025 -40.507 -49.881-14.657 1., 00 42.41
ATOM 6403 0 HOH 2026 -38.801 -23.771 -9.222 1. 00 43.21ATOM 6403 0 HOH 2026 -38.801 -23.771 -9.222 1. 00 43.21
ATOM 6404 0 HOH 2027 -17.948 -12.651 16.689 1. ,00 33.70ATOM 6404 0 HOH 2027 -17.948 -12.651 16.689 1., 00 33.70
ATOM 6405 0 HOH 2028 17.207 - 36.487 -33.577 1. .00 22.78ATOM 6405 0 HOH 2028 17.207-36.487 -33.577 1. .00 22.78
ATOM 6406 0 HOH 2029 - 5.981 -27.062一 31'.729 1.00 37.77ATOM 6406 0 HOH 2029-5.981 -27.062 One 31'.729 1.00 37.77
ATOM 6407 0 HOH 2030 20.761 -36.164 -38.593 1. ,00 20.09ATOM 6407 0 HOH 2030 20.761 -36.164 -38.593 1., 00 20.09
ATOM 6408 0 HOH 2031 -3.853 0.723 -37.104 1. ,00 33.47ATOM 6408 0 HOH 2031 -3.853 0.723 -37.104 1., 00 33.47
ATOM 6409 0 HOH 2032 -35.838 -55.755 -8.829 1. .00 46.41ATOM 6409 0 HOH 2032 -35.838 -55.755 -8.829 1. .00 46.41
ATOM 6410 0 HOH 2033 -21.563 - 5.243 - 25.136 1. .00 28.53ATOM 6410 0 HOH 2033 -21.563-5.243-25.136 1. .00 28.53
ATOM 6411 0 HOH 2034 -19.971 - 15.013 - 39.669 1, .00 34.47ATOM 6411 0 HOH 2034 -19.971-15.013-39.669 1, .00 34.47
ATOM 6412 0 HOH 2035 -30.478 -4.311 17.647 1, .00 30.10ATOM 6412 0 HOH 2035 -30.478 -4.311 17.647 1, .00 30.10
ATOM 6413 0 HOH 2036 -30.725 -33.109 -21■ 837 1, .00 31.45ATOM 6413 0 HOH 2036 -30.725 -33.109 -21 837 1, .00 31.45
ATOM 64H 0 HOH 2037 0.388 1.053 -17.009 1, .00 40.12ATOM 64H 0 HOH 2037 0.388 1.053 -17.009 1, .00 40.12
ATOM 6415 0 HOH 2038 - 7.320 一 2.049 -52.624 1, .00 40.27ATOM 6415 0 HOH 2038-7.320 One 2.049 -52.624 1, .00 40.27
ATOM 6416 0 HOH 2039 9.499 -18.341 -37.428 1 .00 24.05ATOM 6416 0 HOH 2039 9.499 -18.341 -37.428 1 .00 24.05
ATOM 6417 0 HOH 2040 -23.376 3.195 -40.803 1. .00 46.39ATOM 6417 0 HOH 2040 -23.376 3.195 -40.803 1. .00 46.39
ATOM 6418 0 HOH 2041 -0.861 -17.962 -10.625 1, .00 36.43ATOM 6418 0 HOH 2041 -0.861 -17.962 -10.625 1, .00 36.43
ATOM 6419 0 HOH 2042 -50.633 -40.325 -19.009 1. .00 43.48 ATOM 6420 0 HOH 2043 - 50.850 -40.207 -10.760 1.00 54.95 0ATOM 6419 0 HOH 2042 -50.633 -40.325 -19.009 1. .00 43.48 ATOM 6420 0 HOH 2043-50.850 -40.207 -10.760 1.00 54.95 0
ATOM 6421 0 HOH 2044 -39.879 -18.532 -3.462 1. 00 40.50 0ATOM 6421 0 HOH 2044 -39.879 -18.532 -3.462 1.00 40.50 0
ATOM 6422 0 HOH 2045 10.547 -21.460 -31. 041 1. 00 34.33 0ATOM 6422 0 HOH 2045 10.547 -21.460 -31. 041 1.00 34.33 0
ATOM 6423 0 HOH 2046 -10.721 -0.352 -33. 111 1. 00 44.94 0ATOM 6423 0 HOH 2046 -10.721 -0.352 -33. 111 1. 00 44.94 0
ATOM 6424 0 HOH 2047 -9.262 -16.837 -9. 725 1. 00 24.71 0ATOM 6424 0 HOH 2047 -9.262 -16.837 -9. 725 1. 00 24.71 0
ATOM 6425 0 HOH 2048 -19.763 -4.209 12. 169 1. 00 40.95 0ATOM 6425 0 HOH 2048 -19.763 -4.209 12. 169 1. 00 40.95 0
ATOM 6426 0 HOH 2049 -34.401 -30.322 5. 952 1. 00 27.14 0ATOM 6426 0 HOH 2049 -34.401 -30.322 5. 952 1. 00 27.14 0
ATOM 6427 0 HOH 2050 - 33.353 1.964 一 4. 903 1. 00 29.78 0ATOM 6427 0 HOH 2050-33.353 1.964 One 4.903 1.00 29.78 0
ATOM 6428 0 HOH 2051 -36.770 -22.613 - 11. 076 1. 00 38.68 0ATOM 6428 0 HOH 2051 -36.770 -22.613-11. 076 1. 00 38.68 0
ATOM 6429 0 HOH 2052 -18.664 -10.166 -47. 135 1. 00 33.57 0ATOM 6429 0 HOH 2052 -18.664 -10.166 -47. 135 1. 00 33.57 0
ATOM 6430 0 HOH 2053 4.150 -20.378 - 49. 077 1. 00 27.87 QATOM 6430 0 HOH 2053 4.150 -20.378-49. 077 1. 00 27.87 Q
ATOM 6431 0 HOH 2054 -27.841 -30· 789 -6. 750 1. 00 35.33 0ATOM 6431 0 HOH 2054 -27.841 -30 789 -6. 750 1. 00 35.33 0
ATOM 6432 0 HOH 2055 -37.023 -19.514 23. 061 1. 00 34.50 . 0ATOM 6432 0 HOH 2055 -37.023 -19.514 23. 061 1.00 34.50. 0
ATOM 6433 0 HOH 2056 -13.132 -10.530 -51. 955 1. 00 33.46 0ATOM 6433 0 HOH 2056 -13.132 -10.530 -51. 955 1.00 33.46 0
ATOM 6434 0 HOH 2057 -11.087 -3.636 -18. 280 1. 00 22.19 0ATOM 6434 0 HOH 2057 -11.087 -3.636 -18. 280 1. 00 22.19 0
ATOM 6435 0 HOH 2058 -11.615 -28.253 -17. 753 1. 00 31.90 0ATOM 6435 0 HOH 2058 -11.615 -28.253 -17. 753 1. 00 31.90 0
ATOM 6436 0 HOH 2059 1.924 3.921 -20. 172 1. 00 40.22 0ATOM 6436 0 HOH 2059 1.924 3.921 -20. 172 1.00 40.22 0
ATOM 6437 0 HOH 2060 -15.764 -28.456 - 8. 579 1. 00 26.26 0ATOM 6437 0 HOH 2060 -15.764 -28.456-8. 579 1.00 26.26 0
ATOM 6438 0 HOH 2061 -26.302 -8.737 -14. 922 1. ,00 32.29 0ATOM 6438 0 HOH 2061 -26.302 -8.737 -14. 922 1., 00 32.29 0
ATOM 6439 0 HOH 2062 10.763 -33.666 -22. 121 1. ,00 40.69 0ATOM 6439 0 HOH 2062 10.763 -33.666 -22.121 1., 00 40.69 0
ATOM 6440 0 HOH 2063 -13.155 -34.989 -17. 191 1. 00 44.86 0ATOM 6440 0 HOH 2063 -13.155 -34.989 -17. 191 1. 00 44.86 0
ATOM 6441 0 HOH 2064 -7.384 -44.359 -38. 675 1. .00 34.27 0ATOM 6441 0 HOH 2064 -7.384 -44.359 -38. 675 1. .00 34.27 0
ATOM 6442 0 HOH 2065 -32.151 -13.974 14.613 1. 00 32.33 0ATOM 6442 0 HOH 2065 -32.151 -13.974 14.613 1. 00 32.33 0
ATOM 6443 Q HOH 2066 -42.645 -23.113 -2. 329 1. ,00 33.76 0ATOM 6443 Q HOH 2066 -42.645 -23.113 -2. 329 1., 00 33.76 0
ATOM 6444 0 HOH 2067 -9.583 -13.717 -7. 742 1. .00 21.74 0ATOM 6444 0 HOH 2067 -9.583 -13.717 -7. 742 1. .00 21.74 0
ATOM 6445 0 HOH 2068 13.726 - 29.369 -62. 943 1. .00 43.34 0ATOM 6445 0 HOH 2068 13.726-29.369 -62. 943 1. .00 43.34 0
ATOM 6446 0 HOH 2069
Figure imgf000208_0001
-20.218 -39. 771 1. .00 37.90 0ATOM 6446 0 HOH 2069
Figure imgf000208_0001
-20.218 -39. 771 1. .00 37.90 0
ATOM 6447 0 HOH 2070 11.237 -41.595 - 58. 557 1. .00 41.92 0ATOM 6447 0 HOH 2070 11.237 -41.595-58. 557 1. .00 41.92 0
ATOM 6448 0 HOH 2071 -0.683 - 52.985 -42. 114 1, .00 38.06 0ATOM 6448 0 HOH 2071 -0.683-52.985 -42. 114 1, .00 38.06 0
ATO 6450 0 HOH 2072 - 9.548 -16.357 - 6. 927 1, .00 26.83 0ATO 6450 0 HOH 2072-9.548 -16.357-6. 927 1, .00 26.83 0
ATOM 6451 0 HOH 2073 - 33.068 -57.276 0. 000 1. .00 37.44 0ATOM 6451 0 HOH 2073-33.068 -57.276 0. 000 1. .00 37.44 0
ATOM 6452 0 HOH 2074 -46.368 -30.325 -15. 303 1, .00 39.44 0ATOM 6452 0 HOH 2074 -46.368 -30.325 -15. 303 1, .00 39.44 0
ATOM 6453 0 HOH 2075 -25.973 -30.762 - 8. 517 1 .00 32.55 0ATOM 6453 0 HOH 2075 -25.973 -30.762-8. 517 1 .00 32.55 0
ATOM 6454 0 HOH 2076 -44.313 -31.397 -16. 806 1, .00 42.21 0ATOM 6454 0 HOH 2076 -44.313 -31.397 -16. 806 1, .00 42.21 0
ATOM 6455 0 HOH 2077 -38.892 -26.976 - 13. 957 1 • 00 42.66 0ATOM 6455 0 HOH 2077 -38.892 -26.976-13. 957 1 • 00 42.66 0
ATOM 6456 0 HOH 2078 -28.159 -51.862 -22. 838 1 .00 48.68 0 80S ATOM 6456 0 HOH 2078 -28.159 -51.862 -22. 838 1 .00 48.68 0 80S
0 98 ε 00 . 'S 828 '98- 66 ηνζ ■ 0 86fr9 WOIV 0 98 ε 00. 'S 828 '98-66 ηνζ ■ 0 86fr9 WOIV
0 80 SS 00 •L ^Z 'τ 683 ■LZ- 9LL •92 - ■ 0 Z6V9 隨 V0 80 SS 00 • L ^ Z 'τ 683 ■ LZ-9LL • 92-■ 0 Z6V9 隨 V
0 l£ '6S 00 'I 096 •01 OH •ιε- ΪΖΖ ■9ε- ζηζ HOH 0 16W WOIV0 l £ '6S 00' I 096 • 01 OH • ιε- ΪΖΖ 9ε- ζηζ HOH 0 16W WOIV
0 8ん' 6ε 00 Ί 908 ■n OLZ 9οε •Ofr - z HOH 0 06t-9 WOIV0 8 '6ε 00 908 908 nOLZ 9οε • Ofr-z HOH 0 06t-9 WOIV
0 9 9ε 00 L 9Z.6 L OL 'ΖΪ- S99 ■η- 0LI-3 HOH 0 68fr9 WOIV0 9 9ε 00 L 9Z.6 L OL 'ΖΪ- S99 η-0LI-3 HOH 0 68fr9 WOIV
0 SO -6S 00 'L ■9 9Z8 L0£ 60 HOH 0 Z.8W WOIV0 SO -6S 00 'L9 9Z8 L0 £ 60 HOH 0 Z.8W WOIV
0 90 'If 00 l 9LP 'V 06 •6- 6S0 •Ofr - 8013 HOH 0 98W 舰 V0 90 'If 00 l 9LP' V 06 • 6- 6S0 • Ofr-8013 HOH 0 98W 舰 V
0 00 'L OZ 'L 0^9 ■8- 908 ■8ε - Z.0L2 HOH 0 98fr9 WOIV0 00 'L OZ' L 0 ^ 9 ■ 8- 908 ■ 8ε-Z.0L2 HOH 0 98fr9 WOIV
0 10 f 00 Ί 989 ■8 乙 80 ■ - 916 9013 HOH 0 WOIV0 10 f 00 Ί 989 ■ 8 B 80 ■-916 9013 HOH 0 WOIV
0 20 ·8ε 00 Ί ■SI -ει- 062 '6ε- S0L3 HOH 0 WOIV0 20 8ε 00 SISI -ει- 062 '6ε- S0L3 HOH 0 WOIV
0 16 '2f 00 'I ε ι ■6 199 '"- 69ε οιζ HOH 0 38^9 WOIV0 16 '2f 00' I ε ι 6 199 '"-69ε οιζ HOH 0 38 ^ 9 WOIV
0 00 161. ■ L- HOH 0 i WOIV0 00 161. ■ L- HOH 0 i WOIV
0 8^ ε 00 Ί L6 .6 820 ■Ll- ^88 'ss 2013 HOH 0 WOIV0 8 ^ ε 00 Ί L6 .6 820Ll- ^ 88 'ss 2013 HOH 0 WOIV
0 6S ' Z 00 •I SZ6 '8 ZLV ■6L- 90f ■ζ. - 1012 HOH 0 6LP9 WOIV0 6S 'Z 00 • I SZ6' 8 ZLV 6L-90f ζ.-1012 HOH 0 6LP9 WOIV
0 00 ■i ILL ζ 09Z. ■η- iLQ .6ε- 0013 HOH 0 m INOiV0 00 ■ i ILL ζ 09Z. ■ η- iLQ .6ε- 0013 HOH 0 m INOiV
0 68 ' 00 ■i 8fr8 •εζ 68 ■6- 168 ■ss- 6602 HOH 0 WOIV0 68 '00 ■ i 8fr8 εζ 68 ■ 6- 168 ■ ss-6602 HOH 0 WOIV
0 00 Ί 0½ ■61 εεο '3L- οιε 8603 HOH 0 9L 9 WOIV0 00 Ί 0½ ■ 61 εεο '3L- οιε 8603 HOH 0 9L 9 WOIV
0 ιε'6ΐ 00 ,1 U '81 0ん 9 ■8 - 96 ■61- L60Z HOH 0 WOIV0 ιε'6ΐ 00, 1 U '81 0 9 9 8-96 61- L60Z HOH 0 WOIV
0 09 'Z.9 00 'L 0.8 .9 ζιι Ό2- 6 1 ■Sfr- 9603 HOH 0 WOIV0 09 'Z.9 00' L 0.8 .9 ζιι Ό2- 6 1Sfr- 9603 HOH 0 WOIV
0 LZ Of 00 -L 20f ■f- Z9L '62- 686 ■ε 3602 ■ 0 WOIV0 LZ Of 00 -L 20f f-Z9L '62 -686 ■ ε 3602 ■ 0 WOIV
0 oi '8 00 Ί Z.00 Ζ- Ρ80 ΖΖ- 5117 ■ρζ- ^603 HOH 0 zm WOIV0 oi '8 00 Ί Z.00 Ζ- Ρ80 ΖΖ-5117 ρζ- ^ 603 HOH 0 zm WOIV
0 n ' 9 00 -L 308 618 Ό3- 909 S60Z ■ 0 WOIV0 n '9 00 -L 308 618 Ό3- 909 S60Z ■ 0 WOIV
0 6'乙 ε 00 ■i SLS 90 ■6S- 969 01 2603 HOH 0 om WOIV0 6 'O ε 00 ■ i SLS 90 ■ 6S- 969 01 2603 HOH 0 om WOIV
0 00 Ί 990 "92- OSS ZS- ΖΖΖ ■9ε - 1603 HOH 0 69 WOIV0 00 Ί 990 "92- OSS ZS- ΖΖΖ 9ε-1603 HOH 0 69 WOIV
0 99 "9f 00 ■i 9L9 '8- L ■0S- ZL5 'εε- 0602 HOH 0 89 WOIV0 99 "9f 00 ■ i 9L9 '8- L ■ 0S- ZL5' εε- 0602 HOH 0 89 WOIV
0 6S- .9 00 dZL '93- '62- οει ■8ε- 6803 HOH 0 Z.9^9 WOIV0 6S- .9 00 dZL '93-'62-οει 8ε-6803 HOH 0 Z.9 ^ 9 WOIV
0 68-6Z 00 ■I 90S ΌΙ 66 •L - Q9Z 8802 HOH 0 99W WOIV0 68-6Z 00 I 90S ΌΙ 66 • L-Q9Z 8802 HOH 0 99W WOIV
0 00 •L £0Z '81- 'ΐε- ■5ε- LSOZ HOH 0 99W WOIV0 00 • L £ 0Z '81-'ΐε- ■ 5ε- LSOZ HOH 0 99W WOIV
0 £9 ε 00 'L 699 ■9 - L2d •9 o ■ε - 980Ζ HOH 0 WOIV0 £ 9 ε 00 'L 699 ■ 9-L2d • 9 o ■ ε-980Ζ HOH 0 WOIV
0 00 ■i ' - S99 ■SS - Z l 'ΐε- 9802 HOH 0 WOIV0 00 ■ i '-S99 ■ SS-Z l' ΐε-9802 HOH 0 WOIV
0 90'8S 00 ■I L61 6 9 ■I - L99 '0 V80Z HOH 0 Z9 9 WOIV0 90'8S 00 ■ I L61 6 9 ■ I-L99 '0 V80Z HOH 0 Z9 9 WOIV
0 Z.6 Of 00 -L 9 ' 91- SIL 'Π- O L '6S- ΌΒΟΖ HOH 0 L9W WOIV0 Z.6 Of 00 -L 9 '91- SIL' Π- O L '6S- ΌΒΟΖ HOH 0 L9W WOIV
0 z.9 'ττ 00 ■L m ■ιε- 966 ΟΖ- QZL ■L 3803 ■ 0 09fr9 INOIV0 z.9 'ττ 00 ■ L m ■ ιε- 966 ΟΖ- QZL ■ L 3803 ■ 0 09fr9 INOIV
0 00 Ί ZLZ OZ- 600 '93- osz εε- 1802 ■ 0 69fr9 WOiV0 00 Ί ZLZ OZ- 600 '93-osz εε- 1802 ■ 0 69fr9 WOiV
0 £6 ZZ 00 'I zoz ·9ε - ειο -9ε- 9L17 ■ιζ 0802 HOH 0 SQV9 WOIV0 £ 6 ZZ 00 'I zoz9ε-ειο -9ε- 9L17 ιζ 0802 HOH 0 SQV9 WOIV
0 30 'S9 00 ■i 09ん 'SIτη '9ε- 6L0Z HOH 0 LS 9 WOIV 0 30 'S9 00 i09' SIτη '9ε-6L0Z HOH 0 LS 9 WOIV
^LlLO/LOOZdT/l d 0 " 0/600Z OAV 602 ^ LlLO / LOOZdT / ld 0 "0 / 600Z OAV 602
0 frO ■ε 00 LL6 zz- 098 ε t-88 ■6 09 HOH 0 9€99 1N01V 0 frO ε 00 LL6 zz- 098 ε t-88 ■ 6 09 HOH 0 9 € 99 1N01V
0 9 00 ■i S98 - z- m ■0 982 ■6 HOH 0 WOIV0 9 00 ■ i S98-z-m ■ 0 982 ■ 6 HOH 0 WOIV
0 6ん ,8ε 00' I £LV ■61- Z9L ■I 836 1 8^12 HOH 0 εε39 WO丄 V0 6, 8ε 00 'I £ LV ■ 61- Z9L ■ I 836 1 8 ^ 12 HOH 0 εε39 WO 丄 V
0 1-6 'βε 00 I ILL ■U- 16S Z- 'SI UvYl HOH 0 3SS9 1N01V0 1-6 'βε 00 I ILLU- 16S Z-' SI UvYl HOH 0 3SS9 1N01V
0 96 ■ 00 Ί fr86 ■83- •i- S9S ■oi 园 0 1899 匿 V0 96 ■ 00 Ί fr86 ■ 83- • i-S9S ■ oi 园 0 1899
0 06 ss 00 l L99 '63- 966 ■ L99 ■9 SW HOH 0 099 WOIV0 06 ss 00 l L99 '63 -966 ■ L99 ■ 9 SW HOH 0 099 WOIV
0 LL 00 L 286 ■W- 691 •0 - 980 ■SL mz HOH 0 62S9 W01V0 LL 00 L 286 W-691 • 0-980 SL mz HOH 0 62S9 W01V
0 Z.6 00 Ί. 1708 •13- in ■91- 868 ' zm HOH 0 8399 IN01V0 Z.6 00 Ί. 1708 • 13- in ■ 91-868 'zm HOH 0 8399 IN01V
0 81 ■9ε 00 Ί 286 ■οε - εε 'τι- ■9 - HOH 0 LZS9 WO丄 V0 81 ■ 9ε 00 Ί 286 ■ οε-εε 'τι- ■ 9-HOH 0 LZS9 WO 丄 V
0 00 l US ■ ι- 19Z OS - L19 ■9ε - HOH 0 93S9 W01V0 00 l US ■ ι- 19Z OS-L19 ■ 9ε-HOH 0 93S9 W01V
0 ZL 00 L 06 τι- Z06 -IS- L ■8ε- HOH 0 9Z99 W01V0 ZL 00 L 06 τι- Z06 -IS- L8ε- HOH 0 9Z99 W01V
0 εε ■½ 00 ,1 908 ZLL ■os- S90 ' ε- 6ε ΐϋ HOH 0 ½99 W01V0 εε ½½ 00, 1 908 ZLL os- S90 'ε-6ε ΐϋ HOH 0 ½99 W01V
0 L£ ■οε 00 I L9V ■£Z- Sl ■ p- £08 ■8 - HOH 0 £ZQ9 W01V0 L £ ■ οε 00 I L9V ■ £ Z- Sl ■ p- £ 08 ■ 8-HOH 0 £ ZQ9 W01V
0 28 ■017 00 Ί ;ιζ- •ss - 8 LZIZ HOH 0 ZZ59 1/10丄 V0 28 ■ 017 00 Ί; ιζ- • ss-8 LZIZ HOH 0 ZZ59 1/10 丄 V
0 's 00 L 01- ■Sfr- L 2 ■Ζ.9- 9ZIZ HOH 0 L299 iNOlV0 's 00 L 01- ■ Sfr- L 2 ■ Ζ.9- 9ZIZ HOH 0 L299 iNOlV
0 96 00 Ί 61L TL- 9 ■6V- SSL ■is- Q£IZ HOH 0 0399 W01V0 96 00 Ί 61L TL-9 ■ 6V- SSL ■ is- Q £ IZ HOH 0 0399 W01V
0 S6 00 •I L6 ■6 - οοε ■8 Z.6S ■L9- mz HOH 0 61S9 W01V0 S6 00 • I L6 ■ 6-οοε ■ 8 Z.6S ■ L9- mz HOH 0 61S9 W01V
0 89 00 l 9Lf ■8 - 981 ■L9- 121 '29- εειζ HOH 0 81S9 woiv0 89 00 l 9Lf ■ 8-981 ■ L9- 121 '29-εειζ HOH 0 81S9 woiv
0 OS ■is 00 l 926 82- 8Sfr ■Sfr - ■Ofr- Z£IZ HOH 0 91-99 W01V0 OS ■ is 00 l 926 82-8Sfr ■ Sfr-■ Ofr- Z £ IZ HOH 0 91-99 W01V
0 S •2 00 ,1 Z98 .61·- Z.08 ■L - εοο Ό3- ιειζ; HOH 0 WOIV0 S • 2 00, 1 Z98 .61 ·-Z.08 L-εοο Ό3- ιειζ; HOH 0 WOIV
0 ζε •09 00 .1 LIO 'Ll- 999 ■n- 99Ζ "8S- osiz HOH 0 S199 WOIV0 ζε • 09 00 .1 LIO 'Ll- 999 n-99Ζ "8S- osiz HOH 0 S199 WOIV
0 εε 00 l ZW •91- 266 ' 一 zzs '99- \z HOH 0 3L99 INOlV0 εε 00 l ZW91-266 'One zzs '99-\ z HOH 0 3L99 INOlV
0 OL 'SS 00 L n ■ιζ- ZP- 869 99- 8212 HOH 0 U99 WO丄 V0 OL 'SS 00 L n ιζ- ZP- 869 99- 8212 HOH 0 U99 WO 丄 V
0 Z "If 00 LSI ■8L- . 881 ■8 - 8SS 9- LZYl HOH 0 01S9 WOIV0 Z "If 00 LSI ■ 8L-. 881 ■ 8-8SS 9- LZYl HOH 0 01S9 WOIV
0 Z ■ 00 ■i 96Z. ■Ζ - 6 6 ■OS - 90 L •6S- 92 LZ HOH 0' 80S9 WOIV0 Z ■ 00 ■ i 96Z. ■ Ζ-6 6 ■ OS-90 L • 6S- 92 LZ HOH 0 '80S9 WOIV
0 fr9 ~n 00 -L 06ε Ζ- 66 •n- OLO ■8S- HOH 0 L0 9 WOIV0 fr9 ~ n 00 -L 06ε 66- 66 n-OLO 8S- HOH 0 L0 9 WOIV
0 10 ■6 00 'I SZL '61- U9 ■6 L£P ■SS- niz HOH 0 90S9 WOIV0 10 ■ 6 00 'I SZL '61-U9 ■ 6 L £ P ■ SS- niz HOH 0 90S9 WOIV
0 zz *83 00 ■I Z9Q 'ε- 9£9 ·9ε- 9 9 ■8fr- £ZIZ HOH 0 90S9 WOIV0 zz * 83 00 ■ I Z9Q 'ε- 9 £ 9 9ε- 9 9 8fr- £ ZIZ HOH 0 90S9 WOIV
0 2L '9 00 'I IZ '3- ■6ε- 6ZZ 09- ZUZ HOH 0 fr099 INOlV0 2L '9 00' I IZ '3- ■ 6ε-6ZZ 09- ZUZ HOH 0 fr099 INOlV
0 W '63 00 'I 9Z0 .9 LOS τ - OZ^ ·½- iZVZ HOH 0 2099 WOIV0 W '63 00 'I 9Z0 .9 LOS τ-OZ ^ ½- iZVZ HOH 0 2099 WOIV
0 Z.S '6S 00 ■1· 091 .9 8817 '6ε- 18 'frS- ΟΖΪΖ HOH 0 66P9 WOIV0 Z.S '6S 00 1 091 .9 8817' 6ε-18 'frS- ΟΖΪΖ HOH 0 66P9 WOIV
0 20 ■n 00 ,1 98 ■8 969 Ί9- ΖΪΖ '29- 6112 HOH 0 WOIV0 20 ■ n 00, 1 98 ■ 8 969 Ί9- ΖΪΖ '29 -6112 HOH 0 WOIV
0 n 00 ■i 991r ■gi 9L9 'βε- 609 ■εε- 8113 HOH 0 L WOIV0 n 00 ■ i 991r ■ gi 9L9 'βε-609 ■ εε-8113 HOH 0 L WOIV
0 Li 'Us 00 Ί IZ£ ■Zi 9 S '9ε- m •ιε- LUZ HOH 0 96fr9 WOIV0 Li 'Us 00 Ί IZ £ ■ Zi 9 S' 9ε- m • ιε- LUZ HOH 0 96fr9 WOIV
0 Z9 •017 00 'L £Z0 ■91 IZ9 '83- zz- 9U3 HOH 0 S6fr9 WOiV0 Z9 • 017 00 'L £ Z0 ■ 91 IZ9 '83-zz- 9U3 HOH 0 S6fr9 WOiV
0 ■L9 00 ■i SZL ■Li IS9 ■εε- ■8ε— 9U2 HOH 0 ^6^9 WOIV miL0/L00Zdr/L3d 0 ん S0/600 OAV 0X2 0 ■ L9 00 ■ i SZL ■ Li IS9 ■ εε- ■ 8ε— 9U2 HOH 0 ^ 6 ^ 9 WOIV miL0 / L00Zdr / L3d 0 S0 / 600 OAV 0X2
0 9Z 00 ι 066 ■8ϋ - 6SL ■ζ 98 ■ 0 んん S9 W01V 0 9Z 00 ι 066 ■ 8ϋ-6SL ■ ζ 98 ■ 0 S9 W01V
0 τζ ■ 00 ι 098 ■6 L£L 'L- POP ■pz- 98 L2 HOH 0 S£99 W01V0 τζ ■ 00 ι 098 ■ 6 L £ L 'L- POP ■ pz- 98 L2 HOH 0 S £ 99 W01V
0 S8 00 'ι 031 •is- εεο 'Ζ εει '91- mz HOH 0 H59 W01V0 S8 00 'ι 031 • is- εεο' Ζ εει '91-mz HOH 0 H59 W01V
0 ½ ·9 00 ι £96 ■L — εο6 Ό 6εο ζ- ■ 0 3199 隠 V0 ½ · 9 00 ι £ 96 ■ L — εο6 Ό 6εο ζ- ■ 0 3199 Hidden V
0 PS 00 Ί 338 ■ss- ■SL SSP ■6卜 2812 HOH 0 L .99 WO丄 V0 PS 00 Ί 338 ■ ss- ■ SL SSP ■ 6 卜 2812 HOH 0 L .99 WO 丄 V
0 96 ■ε 00 •L 890 8L8 •0 069 ■s- L8L3 HOH 0 0£S9 W01V0 96 ■ ε 00 • L 890 8L8 • 0 069 ■ s- L8L3 HOH 0 0 £ S9 W01V
0 60 '99 00 ■L LS9 ■SS- L19 •ε 'Z- 0813 HOH 0 69S9 賺 V0 60 '99 00 ∎ L LS9 ■ SS- L19 • ε 'Z- 0813 HOH 0 69S9 賺 V
0 L0 'Ζ^ 00 ι 029 ■89- Z.fr6 •8 - 6LIZ HOH 0 8999 1N0IV0 L0 'Ζ ^ 00 ι 029 ■ 89- Z.fr6 • 8-6LIZ HOH 0 8999 1N0IV
0 S9 •99 00 •L I L ■S9- LZ .8ε - 926 'τ— iZ HOH 0 L959 WOiV0 S9 • 99 00 • L I L ■ S9- LZ .8ε-926 'τ— iZ HOH 0 L959 WOiV
0 w 09 00 Ί 9SI ■P9- 699 ■Sfr - no ■01 - LLiZ HOH 0 99S9 W01V0 w 09 00 Ί 9SI ■ P9- 699 ■ Sfr-no ■ 01-LLiZ HOH 0 99S9 W01V
0 69 ■6ε 00 Ί ■69- 90Ζ. ■6ε - 910 ■S- 911 HOH 0 S9S9 W01V0 69 ■ 6ε 00 Ί ■ 69- 90Ζ. ■ 6ε-910 ■ S- 911 HOH 0 S9S9 W01V
0 9 S 00 Ί ■ 9- L19 εε ■S z HOH 0 W99 W01V0 9 S 00 Ί 9- L19 εε S z HOH 0 W99 W01V
0 69 ■ss 00 ■ι 886 ■L9- 91 ■L£- £89 ■9 z HOH 0 S9S9 W01V0 69 ■ ss 00 ■ ι 886 ■ L9- 91 ■ L £-£ 89 ■ 9 z HOH 0 S9S9 W01V
0 IL ZZ 00 Ί LZ •|9- 96V 'ε LS . εηζ HOH 0 29S9 W01V0 IL ZZ 00 Ί LZ • | 9- 96V 'ε LS .εηζ HOH 0 29S9 W01V
0 LL ■£9 00 ■L 639 ■09 - L5 ■6ε- W9 ■p ZLiZ HOH 0 19S9 W01V0 LL ■ £ 9 00 ■ L 639 ■ 09-L5 ■ 6ε- W9 ■ p ZLiZ HOH 0 19S9 W01V
0 ZS 62 00 L 911 HS- ZI ■ιε- 016 ■8- iLiZ HOH 0 0999 WO丄 V0 ZS 62 00 L 911 HS- ZI ■ ιε- 016 ■ 8- iLiZ HOH 0 0999 WO 丄 V
0 61 '6 00 ,1 86S ■09- 8 ■ιε- on 'Z.L- OLIZ HOH 0 6SS9 WO丄 V0 61 '6 00, 1 86S 09- 8 ιε- on' Z.L- OLIZ HOH 0 6SS9 WO 丄 V
0 S8 ■½ 00 L 363 ■8fr- S68 ■οε - ■81- 69 HOH 0 Z.999 I/101V0 S8 ■ ½ 00 L 363 ■ 8fr- S68 ■ οε-■ 81- 69 HOH 0 Z.999 I / 101V
0 SZ. •Sfr 00 L VLO ' - V6Z ■62- 16Z. ■ει - 89 L3 HOH 0 9999 I/J01V0 SZ. • Sfr 00 L VLO '-V6Z ■ 62-16Z. ■ ει-89 L3 HOH 0 9999 I / J01V
0 Zl ■οε 00 ■ι ILL -6ε- 0Ρ9 .9 - 906 -zv- z HOH 0 SSS9 匪 V0 Zl ■ οε 00 ■ ι ILL -6ε- 0Ρ9 .9-906 -zv- z HOH 0 SSS9 匪 V
0 2 OS 00 L 688 L90 .εε - 99S 'SL- 9912 HOH 0 P559 WO丄 V0 2 OS 00 L 688 L90 .εε-99S 'SL- 9912 HOH 0 P559 WO 丄 V
0 SS "99 00 ■L 263 - 09ん ■81- ■8L- S9L2 HOH 0 89S9 INOIV0 SS "99 00 ■ L 263-09 N ■ 81- ■ 8L- S9L2 HOH 0 89S9 INOIV
0 81 ■ζ.ε 00 ■1 Z.6fr ■8ε- OLl ■02- 988 τι- mz HOH 0 3S99 WO丄 V0 81 ■ ζ.ε 00 ■ 1 Z.6fr ■ 8ε- OLl ■ 02- 988 τι- mz HOH 0 3S99 WO 丄 V
0 " οε 9ε 00 ■1 866 •εε - ■9Ζ- 08fr •L- HOH 0 LS99 W01V0 "οε 9ε 00 ■ 1 866 • εε-■ 9Ζ- 08fr • L- HOH 0 LS99 W01V
0 38 .8 00 ■L on ■ζε- ειι ■\ζ- LOZ τι- 2912 HOH 0' 0SS9 W01V0 38 .8 00 ■ L on ■ ζε- ειι ■ \ ζ- LOZ τι- 2912 HOH 0 '0SS9 W01V
0 frS Έ9 00 Ί Z.69 'οε— '92- 9^L L9L3 HOH 0 6½9 INOIV0 frS Έ9 00 Ί Z.69 'οε— '92-9 ^ L L9L3 HOH 0 6½9 INOIV
0 fO ■6ε 00 ■ι 031. ■ε 969 ■L- 086 ■8 0912 HOH 0 8 9 W01V0 fO 6ε 00 ■ ι 031. ■ ε 969 ■ L- 086 ■ 8 0912 HOH 0 8 9 W01V
0 ん 0 -η 00 •1 PL9 ■6ε - Llf ■8 - 8LS ■ιι 69 HOH 0 WOIV0 0 -η 00 • 1 PL9 ■ 6ε-Llf ■ 8-8LS ■ ιι 69 HOH 0 WOIV
0 ZZ -η 00 Ί 098 τ - ΖΖΟ ■8 - 9L9 'τ 89 L3 HOH 0 91799 INOIV0 ZZ -η 00 Ί 098 τ-ΖΖΟ8-9L9 'τ 89 L3 HOH 0 91799 INOIV
0 9ε ζε 00 U 99f ■ζ - 9Ζ.9 •L- ε½ -u L51Z HOH 0 W01V0 9ε ζε 00 U 99f ζ-9Ζ.9L- ε½ -u L51Z HOH 0 W01V
0 26 ■ 00 "L S69 "ΐε- IPO L- S18 •LI 9912 HOH 0 ε½9 W01V0 26 ■ 00 "L S69" ΐε- IPO L- S18 • LI 9912 HOH 0 ε½9 W01V
0 19 'η 00 Ί Z.9C ■62- 591 •0 LOO XL 551Z HOH 0 ZP99 WO丄 V0 19 'η 00 Ί Z.9C ■ 62- 591 • 0 LOO XL 551Z HOH 0 ZP99 WO 丄 V
0 Sfr 00 •ι LLZ ■οε- εβε 'L 12L ■OL HOH 0 6S99 INOIV0 Sfr 00 • ι LLZ ■ οε- εβε 'L 12L ■ OL HOH 0 6S99 INOIV
0 Zl ■8fr 00 Ί 68Z 88S Ί 109 'ίΛ £QIZ HOH 0 8899 W01V0 Zl 8fr 00 Ί 68Z 88S Ί 109 'ίΛ £ QIZ HOH 0 8899 W01V
0 00 Η LBV τζ- 698 ■9 86S •n 3 13 HOH 0 LS99 INOIV0 00 Η LBV τζ- 698 986Sn 3 13 HOH 0 LS99 INOIV
0 '9ε 00 "L ILO SL6 986 zi 151Z HOH 0 9899 INOIV 0 '9ε 00 "L ILO SL6 986 zi 151Z HOH 0 9899 INOIV
SSLlLO/LOOZdT/lDd 0CZ.S0/600Z: O/A ATOM 6578 0 HOH 2187 -3. 558 - 1. 458 -33. 724 1. 00 30. 08 0SSLlLO / LOOZdT / lDd 0CZ.S0 / 600Z: O / A ATOM 6578 0 HOH 2187 -3. 558-1. 458 -33. 724 1. 00 30. 08 0
ATOM 6579 0 HOH 2188 -17. 147 -0. 018 -23. 876 1. 00 31. 04 0ATOM 6579 0 HOH 2188 -17. 147 -0. 018 -23. 876 1. 00 31. 04 0
ATOM 6580 0 HOH 2189 - 0. 091 - 1. 628 - 24. 732 1. 00 25. 92 0ATOM 6580 0 HOH 2189-0. 091-1. 628-24. 732 1. 00 25. 92 0
ATOM 6581 0 HOH 2190 - 1. 683 - 45. 246 -31. 517 1. 00 31. 32 0ATOM 6581 0 HOH 2190-1. 683-45. 246 -31. 517 1. 00 31. 32 0
ATOM 6582 0 HOH 2191 -11. 048一 39. 067 -40. 290 1. 00 52. 35 0ATOM 6582 0 HOH 2191 -11. 048 1 39. 067 -40. 290 1. 00 52. 35 0
ATOM 6583 0 HOH 2192 -9. 866 -37. 685 -37. 616 1. 00 48. 99 0ATOM 6583 0 HOH 2192 -9. 866 -37. 685 -37. 616 1. 00 48. 99 0
ATOM 6584 0 HOH 2193 8. 701 -24. 555 -60. 680 1. 00 33. 22 0ATOM 6584 0 HOH 2193 8. 701 -24. 555 -60. 680 1. 00 33. 22 0
ATOM 6585 0 HOH 2194 8. 070 -27. 260 -62. 937 1. 00 54. 29 0ATOM 6585 0 HOH 2194 8. 070 -27. 260 -62. 937 1. 00 54. 29 0
ATOM 6586 0 HOH 2195 9. 684 -25. 813 -49. 046 1. 00 27. 89 0ATOM 6586 0 HOH 2195 9. 684 -25. 813 -49. 046 1. 00 27. 89 0
ATOM 6587 0 HOH 2196 7. 338 - 42. 698 -49. 180 1. 00 42. 11 0ATOM 6587 0 HOH 2196 7. 338-42. 698 -49. 180 1. 00 42. 11 0
ATOM 6588 0 HOH 2197 7. 421 -39. 115 -48. 515 1 . 00 32. 16 0ATOM 6588 0 HOH 2197 7. 421 -39. 115 -48. 515 1 .00 32. 16 0
ATOM 6589 .0 HOH 2198 12. 363 -39. 759 - 52. 306 1. 00 40. 58 0ATOM 6589 .0 HOH 2198 12. 363 -39. 759-52. 306 1. 00 40. 58 0
ATOM 6590 0 HOH 2199 14. 172 -18. 967 -32. 279 1. 00 29. 52 0ATOM 6590 0 HOH 2199 14. 172 -18. 967 -32. 279 1. 00 29. 52 0
ATOM 6591 0 HOH 2200 17. 621 -52. 034 -48. 263 1. 00 52. 42 0ATOM 6591 0 HOH 2200 17. 621 -52. 034 -48. 263 1. 00 52. 42 0
ATOM 6592 0 HOH 2201 17. 328 - 52. 623 -52. 396 1. 00 43. 11 0ATOM 6592 0 HOH 2201 17. 328-52. 623 -52. 396 1. 00 43. 11 0
ATOM 6593 0 HOH 2202 11. 331 -36. 335 -27. 186 1. 00 30. 15 0ATOM 6593 0 HOH 2202 11. 331 -36. 335 -27. 186 1. 00 30. 15 0
ATOM 6594 0 HOH 2203 5. 286 - 54. 317 -34. 606 1. 00 47. 25 0ATOM 6594 0 HOH 2203 5. 286-54. 317 -34. 606 1. 00 47. 25 0
ATOM 6595 0 HOH 2204 2. 126 -54. 136 -40. 041 1. 00 49. 55 0ATOM 6595 0 HOH 2204 2. 126 -54. 136 -40. 041 1. 00 49. 55 0
ATOM 6596 0 HOH 2205 2. 435 -57. 803 -41. 568 1. 00 45. 79 0ATOM 6596 0 HOH 2205 2. 435 -57. 803 -41. 568 1. 00 45. 79 0
ATOM 6597 0 HOH 2206 9. 223 -56. 594 -33. 924 1. 00 47. 27 0ATOM 6597 0 HOH 2206 9. 223 -56. 594 -33. 924 1. 00 47. 27 0
ATOM 6598 0 HOH 2207 5. 975 -48. 277 - 26. 841 1. 00 43. 56 0ATOM 6598 0 HOH 2207 5. 975 -48. 277-26. 841 1. 00 43. 56 0
ATOM 6599 0 HOH 2208 4. 624 - 52. 768 -29. 809 1. 00 51. 86 0ATOM 6599 0 HOH 2208 4. 624-52. 768 -29. 809 1. 00 51. 86 0
ATOM 6600 0 HOH 2209 9. 465 -49. 607 -29. 561 1. 00 35. 63 0ATOM 6600 0 HOH 2209 9. 465 -49. 607 -29. 561 1. 00 35. 63 0
ATOM 6601 0 HOH 2210 6. 887 -53. 261 - 32. 388 1. 00 55. 07 0ATOM 6601 0 HOH 2210 6. 887 -53. 261-32. 388 1. 00 55. 07 0
ATOM 6602 0 HOH 2211 -5. 176 - 33. 136 -32. 141 1. 00 42. 98 0ATOM 6602 0 HOH 2211 -5. 176-33. 136 -32. 141 1. 00 42. 98 0
ATOM 6603 0 HOH 2212 2. 438 -43. 205 -52. 627 1. 00 36. 21 0ATOM 6603 0 HOH 2212 2. 438 -43. 205 -52. 627 1. 00 36. 21 0
ATOM 6604 0 HOH 2213 6. 404 -47. 027 -48. 689 1. 00 35. 06 0ATOM 6604 0 HOH 2213 6. 404 -47. 027 -48. 689 1. 00 35. 06 0
ATOM 6605 0 HOH 2214 5. 638 -46. 135 -54. 477 1. 00 48. 74 0ATOM 6605 0 HOH 2214 5. 638 -46. 135 -54. 477 1. 00 48. 74 0
ATOM 6606 0 HOH 2215 -38. 387 - 32. 878 12. 600 1. 00 54. 38 0ATOM 6606 0 HOH 2215 -38. 387-32. 878 12. 600 1. 00 54. 38 0
ATOM 6607 0 HOH 2216 -19. 252 -27. 968 -22. 494 1. 00 56. 89 0ATOM 6607 0 HOH 2216 -19. 252 -27. 968 -22. 494 1. 00 56. 89 0
ATOM 6608 0 HOH 2217 -18. 191 -35. 734 -23. 608 1. 00 48. 84 0ATOM 6608 0 HOH 2217 -18. 191 -35. 734 -23. 608 1. 00 48. 84 0
ATOM 6609 0 HOH 2218 - 20. 898 - 34. 170 -23. 183 1. 00 40. 08 0ATOM 6609 0 HOH 2218-20. 898-34. 170 -23. 183 1. 00 40. 08 0
ATOM 6610 0 HOH 2219 -15. 291 -37. 536 -22. 809 1. 00 50. 16 0ATOM 6610 0 HOH 2219 -15. 291 -37. 536 -22. 809 1. 00 50. 16 0
ATOM 6611 0 HOH 2220 -19. 035 -36. 931 -18. 427 1. 00 37. 01 0ATOM 6611 0 HOH 2220 -19. 035 -36. 931 -18. 427 1. 00 37. 01 0
ATOM 6612 0 HOH 2221 - 18. 244 - 35. 462 -20. 844 1. , 00 47. 01 0ATOM 6612 0 HOH 2221-18. 244-35. 462 -20. 844 1., 00 47. 01 0
ATOM 6613 0 HOH 2222 -14. 136一 28.フ 04 -15. 680 1. 00 39. 54 0 ATOM 6614 0 HOH 2223 -16. 394 - 39. 648 -15. 686 1. 00 33. 86 0ATOM 6613 0 HOH 2222 -14. 136 1 28.F 04 -15. 680 1. 00 39. 54 0 ATOM 6614 0 HOH 2223 -16. 394-39. 648 -15. 686 1. 00 33. 86 0
ATOM 6616 0 HOH 2224 23. 123 -22. 139 - 20. 938 1. 00 57. 14 0ATOM 6616 0 HOH 2224 23. 123 -22. 139-20. 938 1. 00 57. 14 0
ATOM 6617 0 HOH 2225 23. 1 18 -24. 761 -23. 218 1. 00 44. 52 0ATOM 6617 0 HOH 2225 23. 1 18 -24. 761 -23. 218 1. 00 44. 52 0
ATOM 6618 0 HOH 2226 21. 390 -24. 814一 25. 405 1. 00 44, 20 0ATOM 6618 0 HOH 2226 21. 390 -24. 814 1 25. 405 1. 00 44, 20 0
ATOM 6619 0 HOH 2227 24. 370 -23. 266 -25. 713 1. 00 46. 09 0ATOM 6619 0 HOH 2227 24. 370 -23. 266 -25. 713 1. 00 46. 09 0
ATOM 6620 0 HOH 2228 22. 368 -16. 520 - 27. 222 1. 00 45. 15 0ATOM 6620 0 HOH 2228 22. 368 -16. 520-27. 222 1. 00 45. 15 0
ATOM 6621 0 HOH 2229 21. 330 -19. 476 -24. 417 1. 00 48. 42 0ATOM 6621 0 HOH 2229 21. 330 -19. 476 -24. 417 1. 00 48. 42 0
ATOM 6622 0 HOH 2230 - 9. 873 -18. 406 -56. 327 1. 00 52. 00 0ATOM 6622 0 HOH 2230-9. 873 -18. 406 -56. 327 1. 00 52. 00 0
ATOM 6623 0 HOH 2231 - 5. 746 - 18. 516 -51. 895 1. 00 36. 31 0ATOM 6623 0 HOH 2231-5. 746-18. 516 -51. 895 1. 00 36. 31 0
ATOM 6624 0 HOH 2232 -8. 515 -20. 040 - 53. 975 1. 00 40. 69 0ATOM 6624 0 HOH 2232 -8. 515 -20. 040-53. 975 1. 00 40. 69 0
ATOM 6625 0 HOH 2233 一 24. 565 -13. 482 - 20. 515 1. 00 .45. 34 0ATOM 6625 0 HOH 2233 1 24. 565 -13. 482-20. 515 1. 00 .45. 34 0
ATOM 6626 . 0 HOH 2234 -21 . 600 -13. 820 -22. 613 1. 00 51. 64 0ATOM 6626. 0 HOH 2234 -21. 600 -13. 820 -22. 613 1. 00 51. 64 0
ATOM 6627 0 HOH 2235 - 21. 537 - 17. 243 -24. 900 1. 00 56. 58 0ATOM 6627 0 HOH 2235-21. 537-17. 243 -24. 900 1. 00 56. 58 0
ATOM 6628 0 HOH 2236 - 28. 798 -10. 572 -13. 490 1. 00 46. 84 0ATOM 6628 0 HOH 2236-28. 798 -10. 572 -13. 490 1. 00 46. 84 0
ATOM 6629 0 HOH 2237 -22. 094 -34. 379 - 33. 490 1. 00 47. 96 0ATOM 6629 0 HOH 2237 -22. 094 -34. 379-33. 490 1. 00 47. 96 0
ATOM 6630 0 HOH 2238 - 22. 365 -31. 848 - 31. 641 1. 00 59. 39 0ATOM 6630 0 HOH 2238-22. 365 -31. 848-31. 641 1. 00 59. 39 0
ATOM 6631 0 HOH 2239 -18. 054 -32. 129 -33. 051 1. 00 40. 95 0ATOM 6631 0 HOH 2239 -18. 054 -32. 129 -33. 051 1. 00 40. 95 0
ATOM 6632 0 HOH 2240 - 25. 635 -50. 620 -24. 685 1. , 00 47. 72 0ATOM 6632 0 HOH 2240-25. 635 -50. 620 -24. 685 1., 00 47. 72 0
ATOM 6634 0 HOH 2241 -28. 376 -46. 332 -33. 183 1. , 00 57. 05 0ATOM 6634 0 HOH 2241 -28. 376 -46. 332 -33. 183 1., 00 57. 05 0
ATOM 6635 0 HOH 2242 -28. 244 - 38. 605 -34. 586 1. 00 58. 83 0ATOM 6635 0 HOH 2242 -28. 244-38. 605 -34. 586 1. 00 58. 83 0
ATOM 6636 0 HOH 2243 -21. 192 -31. 566 - 8. 560 1. 00 27. 50 0ATOM 6636 0 HOH 2243 -21. 192 -31. 566-8. 560 1. 00 27. 50 0
ATOM 6637 0 HOH 2244 - 19. 636 -31. 967 -6. 440 1. . 00 44. 73 0ATOM 6637 0 HOH 2244-19. 636 -31. 967 -6. 440 1.. 00 44. 73 0
ATOM 6638 0 HOH 2245 -39. 644 -12. 642 -3. 789 1. . 00 39. 37 0ATOM 6638 0 HOH 2245 -39. 644 -12. 642 -3. 789 1.. 00 39. 37 0
ATOM 6639 0 HOH 2246 - 43. 149 - 17. 231 - 3. 262 1. 00 49. 89 0ATOM 6639 0 HOH 2246-43. 149-17. 231-3. 262 1. 00 49. 89 0
ATOM 6640 0 HOH 2247 -23. 950 -21. 133 23. 413 1. 00 37. 55 0ATOM 6640 0 HOH 2247 -23. 950 -21. 133 23. 413 1. 00 37. 55 0
ATOM 6641 0 HOH 2248 -25. 239 - 38. 424 -34. 842 1. , 00 43. 34 0ATOM 6641 0 HOH 2248 -25. 239-38. 424 -34. 842 1., 00 43. 34 0
ATOM 6642 0 HOH 2249 -9. 963 -14. 355 -10. 499 1. 00 39. 52 0ATOM 6642 0 HOH 2249 -9. 963 -14. 355 -10. 499 1. 00 39. 52 0
ATOM 6643 0 HOH 2250 -16. 404 - 12. 901 -12. 806 1. 00 33. 07 0ATOM 6643 0 HOH 2250 -16. 404-12. 901 -12. 806 1. 00 33. 07 0
ATOM 6644 0 HOH 2251 -23. 077 -3. 023 8. 134 1. 00 51. 73 0ATOM 6644 0 HOH 2251 -23. 077 -3. 023 8. 134 1. 00 51. 73 0
ATOM 6645 0 HOH 2252 -28. 254 2. 328 10. 057 1. . 00 49. 21 0ATOM 6645 0 HOH 2252 -28. 254 2. 328 10. 057 1.. 00 49. 21 0
ATOM 6646 0 HOH 2253 -21. 538 -7. 952 3. 981 1. , 00 30. 40 0ATOM 6646 0 HOH 2253 -21. 538 -7. 952 3. 981 1., 00 30. 40 0
ATOM 6647 0 HOH 2254 -26. 691 3. 226 —4. 899 1. , 00 37. 29 0ATOM 6647 0 HOH 2254 -26. 691 3. 226 —4. 899 1., 00 37. 29 0
ATOM 6648 0 HOH 2255 -17. 341 - 0. 652 -13. 077 1. . 00 34. 68 0ATOM 6648 0 HOH 2255 -17. 341-0. 652 -13. 077 1.. 00 34. 68 0
ATOM 6649 0 HOH 2256 - 35. 561 -2. 386 -0. 320 1. . 00 44. 66 0ATOM 6649 0 HOH 2256-35. 561 -2. 386 -0. 320 1.. 00 44. 66 0
ATOM 6650 0 HOH 2257 -33. 080 3. 375 1. 453 1. , 00 37. 54 0ATOM 6650 0 HOH 2257 -33. 080 3. 375 1. 453 1., 00 37. 54 0
ATOM 6651 0 HOH 2258 -35. 615 -1. 044 7. 192 1. , 00 44. 15 0 0 εο■8fr 00 L 889■ζε- 98fr "ίΐ 89 L - 6 HOH 0 Z.699 W01VATOM 6651 0 HOH 2258 -35. 615 -1. 044 7. 192 1., 00 44. 15 0 0 εο 8fr 00 L 889 ζε- 98fr "ίΐ 89 L-6 HOH 0 Z.699 W01V
0 88 00 L 889 οε- εεβ ■81· Ι .Ο ΌΙ- £623 HOH 0 9699 W01V0 88 00 L 889 οε- εεβ 81 · Ι .Ο ΌΙ- £ 623 HOH 0 9699 W01V
0 96 00 ■i 299 ■ss - OIL 'ΖΙ SOfr OL- 2632 HOH 0 S699 W01V0 96 00 ■ i 299 ■ ss-OIL 'ΖΙ SOfr OL- 2632 HOH 0 S699 W01V
0 11 ,8ε 00 l 009 •92- οεん 6ん 6 9 16 HOH 0 W99 W01V0 11, 8ε 00 l 009 • 92- οε 6 6 9 16 HOH 0 W99 W01V
0 S6 '6f 00 L fr08 ε - L08 Ί- 28S 'OL OQZZ HOH 0 S699 W01V0 S6 '6f 00 L fr08 ε-L08 Ί- 28S' OL OQZZ HOH 0 S699 W01V
0 ει ■Ifr 00 L L09 ■03 - P80 S9L OS- 68 HOH 0 2699 W01V0 ει ■ Ifr 00 L L09 03-P80 S9L OS- 68 HOH 0 2699 W01V
0 28 •6fr 00 ■i 309 ■S3- Z9P ε - 80S "8 - 8823 HOH 0 0699 W01V0 28 • 6fr 00 ■ i 309 ■ S3- Z9P ε-80S "8-8823 HOH 0 0699 W01V
0 89 '9fr 00 l εΐ9 ■6- U8 ■9ε- ZOS "99- ん 8 HOH 0 6899 IN01V0 89 '9fr 00 l εΐ9 6-U8 9ε-ZOS "99- 8 HOH 0 6899 IN01V
0 LB HQ 00 - L 808 'τ εο9 ■εε- OIZ -6fr- 98 HOH 0 8899 W01V0 LB HQ 00-L 808 'τ εο9εε- OIZ -6fr- 98 HOH 0 8899 W01V
0 LL S 00 - L SS8 ■L L- 669 -LV- S8s ε - 9822 HOH 0 899 WO丄 V0 LL S 00-L SS8L L- 669 -LV- S8s ε-9822 HOH 0 899 WO 丄 V
0 80 '0 00 ' I 992 '91 669 't^- HOH . 0 9899 1N01V0 80 '0 00' I 992 '91 669 't ^-HOH. 0 9899 1N01V
0 6£ LS 00 ■L 698 ■9 S99 ■9S - £si τζ- ZQZZ HOH 0 W99 W01V0 6 £ LS 00 ■ L 698 ■ 9 S99 ■ 9S-£ si τζ- ZQZZ HOH 0 W99 W01V
0 Z.6 ■Us 00 ' I ん 69 ■9 90V 396 ε- 28 HOH 0 8899 W01V0 Z.6 Us 00 'I 69 69 9 90V 396 ε- 28 HOH 0 8899 W01V
0 O .9 00 Ί 06 6- ι ιε 'ss— 291 'Ζξ- 13ZZ HOH 0 3899 W01V0 O .9 00 Ί 06 6- ι ιε 'ss— 291' Ζξ- 13ZZ HOH 0 3899 W01V
0 ん 8 ,SS 00 L ζ ιζ •8 βεε ■η- εεん .ofr - 08 HOH 0 1899 隱 V0 8, SS 00 L ζ ιζ • 8 βεε η-εε .ofr-08 HOH 0 1899 隱 V
0 Ofr 89 00 ■i 090 C99 896■ Lfr- 6LZZ HOH 0 0899 IN01V0 Ofr 89 00i 090 C99 896Lfr-6LZZ HOH 0 0899 IN01V
0 9fr ■ε 00 ■i 688 τι 860 " ΐε- 9L0 .6S- LZZ HOH 0 6 99 WOIV0 9fr ■ ε 00 ■ i 688 τι 860 "ΐε- 9L0 .6S- LZZ HOH 0 6 99 WOIV
0 OV ■LS 00 ■i 9 L 'S3 989 ■SL- sss -οε- LLZZ HOH 0 "99 W01V0 OV ■ LS 00 ■ i 9 L 'S3 989 ■ SL- sss -οε- LLZZ HOH 0 "99 W01V
0 98 ■Sfr 00 LQL OL 03ε Ζ- 999 ' - 9LZZ HOH 0 9Z.99 W01V0 98 Sfr 00 LQL OL 03ε Ζ-999 '-9LZZ HOH 0 9Z.99 W01V
0 9S ■£f 00 l L50 ■81 LZZ '61- 0L8 'Sfr- SLZZ HOH 0 SZ.99 W01V0 9S £ f 00 l L50 81 LZZ '61-0L8 'Sfr- SLZZ HOH 0 SZ.99 W01V
0 E9 ■Z.9 00 ■L OSL Ό3- LZL •τι - 6L£ ·εε- UZZ HOH 0 3Z.99 W01V0 E9 ■ Z.9 00 ■ L OSL Ό3- LZL τι-6L £ εε- UZZ HOH 0 3Z.99 W01V
0 9 ■L 00 ■I LZL ' iZ- 6L9 '6L- 9 8 'ζ,ε- 2L HOH 0 99 W01V0 9 ■ L 00 ■ I LZL 'iZ-6L9' 6L-9 8'ζ, ε-2L HOH 0 99 W01V
0 9 ■Sfr 00 81- C9 L ε- OZL ' - ZLZZ HOH 0 8999 W01V0 9 Sfr 00 81- C9 L ε- OZL '-ZLZZ HOH 0 8999 W01V
0 OZ - LS 00 ■i . 9SL Z.S -6l- VLZZ HOH 0 乙 999 WO丄 V0 OZ-LS 00 ■ i .9SL Z.S -6l- VLZZ HOH 0 O 999 WO 丄 V
0 8L '8 00 ■i Li ■8 08fr ■f- 19L -Ll- OLZZ HOH 0 9999 W01V0 8L '8 00 ■ i Li ■ 8 08fr ■ f- 19L -Ll- OLZZ HOH 0 9999 W01V
0 69 00 ■i 8LS •τ S99 ■ζ - εοο .8卜 69Z3 0 W99 IN01V0 69 00 ∎i 8LS • τ S99 ∎ζ-εοο .8 卜 69Z3 0 W99 IN01V
0 LB ■ S 00 ■L 8fr9 "8 Z5L Ί 6S0 n- 8932 ■ 0 S999 WO丄 V0 LB ■ S 00 ■ L 8fr9 "8 Z5L Ί 6S0 n- 8932 ■ 0 S999 WO 丄 V
0 8 ■Z9 00 .1 LH .8 ½0 ■9 - LOZ '£Ζ- L9ZZ HOH 0 3999 W01V0 8 ■ Z9 00 .1 LH .8 ½0 ■ 9-LOZ '£ Ζ- L9ZZ HOH 0 3999 W01V
0 '9 00 ■L ZZ9 - L- εεο •OL- zzv ov- 99ZZ HOH 0 1999 W01V0 '9 00 ■ L ZZ9-L- εεοOL- zzv ov- 99ZZ HOH 0 1999 W01V
0 96 ■εε 00 ' L 8fr8 -9L- βεε Ί- 82 S9 HOH 0 0999 W01V0 96 εε 00 'L 8fr8 -9L- βεε Ί- 82 S9 HOH 0 0999 W01V
0 ZZ 00 " I 828 •Sl- ζιε 'ο- S68 '92- V9ZZ HOH 0 6999 WO丄 V0 ZZ 00 "I 828 • Sl- ζιε 'ο- S68 '92-V9ZZ HOH 0 6999 WO 丄 V
0 £1 ZZ 00 ' I L9S Ό 036 Z 9 ·9ε- S9ZZ HOH 0 8999 W01V0 £ 1 ZZ 00 'I L9S Ό 036 Z 9 9ε- S9ZZ HOH 0 8999 W01V
0 91 ■6ε 00 Ί 808 ■8 - ISZ. 一 ζ ιν .οε- Z9ZZ HOH 0 iL999 IN01V0 91 ■ 6ε 00 808 808 ■ 8-ISZ. One ζ ιν .οε- Z9ZZ HOH 0 iL999 IN01V
0 93 ■LS 00 ■i 029 'L sss "3ε- 1923 HOH 0 9999 W01V0 93 ■ LS 00 ■ i 029 'L sss "3ε-1923 HOH 0 9999 W01V
0 93 'SS 00 Ί ZLl ■L - 038 '63- 09 HOH 0 S99 WO丄 V0 93 'SS 00 Ί ZLlL-038 '63-09 HOH 0 S99 WO 丄 V
0 OS Z 00 Ί 9W •SL οονο 'Ζ - 6 ZZ HOH 0 3999 W01V 0 OS Z 00 Ί 9WSL SLοονο 'Ζ-6 ZZ HOH 0 3999 W01V
^LlL0/L00Zd£/13d 0 ん S0/600Z OAV ATOM 6698 0 HOH 2295 -11. 122 15. 464 - 31. 635 1. 00 57. 40 0^ LlL0 / L00Zd £ / 13d 0 S0 / 600Z OAV ATOM 6698 0 HOH 2295 -11. 122 15. 464-31. 635 1. 00 57. 40 0
ATOM 6699 0 HOH 2296 -6. 515 21. 981 -34. 186 1. 00 50. 47 0ATOM 6699 0 HOH 2296 -6. 515 21. 981 -34. 186 1. 00 50. 47 0
ATOM 6700 0 HOH 2297 - 8. 396 -2. 090 - 33. 796 1. 00 29. 87 0ATOM 6700 0 HOH 2297-8. 396 -2. 090-33. 796 1. 00 29. 87 0
ATOM 6701 0 HOH 2298 7. 661 -51. 941 - 44. 676 1. 00 50. 70 0ATOM 6701 0 HOH 2298 7. 661 -51. 941-44. 676 1. 00 50. 70 0
ATOM 6703 0 HOH 2299 - 30. 196 -32. 349 -34. 747 1. , 00 47. 78 0ATOM 6703 0 HOH 2299-30. 196 -32. 349 -34. 747 1., 00 47. 78 0
ATOM 6704 0 HOH 2300 -6. 949 8. 081 9. 354 1. 00 40. 67 0ATOM 6704 0 HOH 2300 -6. 949 8. 081 9. 354 1. 00 40. 67 0
ATOM 6705 0 HOH 2301 - 18. 557 -10. 726 -23. 308 1. 00 40. 37 0ATOM 6705 0 HOH 2301-18. 557 -10. 726 -23. 308 1. 00 40. 37 0
ATOM 6706 0 HOH 2302 -19. 524 -11. 404 - 20. 345 1. 00 44. 16 0ATOM 6706 0 HOH 2302 -19. 524 -11. 404-20. 345 1. 00 44. 16 0
ATOM 6708 0 HOH 2303 -18. 852 -16. 212 - 27. 743 1. 00 40. 18 0ATOM 6708 0 HOH 2303 -18. 852 -16. 212-27. 743 1. 00 40. 18 0
ATOM 6709 0 HOH 2304 -19. 252 -16. 423 -23. 924 1. 00 48. 55 0ATOM 6709 0 HOH 2304 -19. 252 -16. 423 -23. 924 1. 00 48. 55 0
ATOM 6710 0 HOH 2305 -21. 544 -11. 261 4. 794 1. . 00 27. 36 0ATOM 6710 0 HOH 2305 -21. 544 -11. 261 4. 794 1.. 00 27. 36 0
ATOM 6711 . 0 HOH 2306 -20. 028 0. 232 -12. 075 1. , 00 45. 17 0ATOM 6711. 0 HOH 2306 -20. 028 0. 232 -12. 075 1., 00 45. 17 0
ATOM 6712 0 HOH 2307 -21. 571 2. 728 -6. 134 1. 00 47. 84 ― 0ATOM 6712 0 HOH 2307 -21. 571 2. 728 -6. 134 1. 00 47. 84 ― 0
ATOM 6713 0 HOH 2308 - 22. 942 2. 359 - 10. 535 1. 00 52. 59 0ATOM 6713 0 HOH 2308-22. 942 2. 359-10. 535 1. 00 52. 59 0
ATOM 6714 0 HOH 2309 -27. 389 3. 551 -11. 961 1. , 00 59. 80 0ATOM 6714 0 HOH 2309 -27. 389 3. 551 -11. 961 1., 00 59. 80 0
ATOM 6715 0 HOH 2310 -26. 992 5. 366 -14. 883 1. , 00 39. 64 0ATOM 6715 0 HOH 2310 -26. 992 5. 366 -14. 883 1., 00 39. 64 0
ATOM 6716 0 HOH 2311 -16. 103 -3. 965 -20. 148 1. 00 57. 89 0ATOM 6716 0 HOH 2311 -16. 103 -3. 965 -20. 148 1. 00 57. 89 0
ATOM 6717 0 HOH 2312 -20. 903 -6. 427 -22. 230 1. , 00 42. 20 0ATOM 6717 0 HOH 2312 -20. 903 -6. 427 -22. 230 1., 00 42. 20 0
ATOM 6719 0 HOH 2313 -13. 734 0. 908 -9. 623 1. , 00 54. 57 0ATOM 6719 0 HOH 2313 -13. 734 0. 908 -9. 623 1., 00 54. 57 0
ATOM 6720 0 HOH 2314 -8. 513 -5. 999 -8. 232 1. 00 50. 35 0ATOM 6720 0 HOH 2314 -8. 513 -5. 999 -8. 232 1. 00 50. 35 0
ATOM 6721 0 HOH 2315 -9. 941 -7. 450 -16. 220 1. 00 38. 78 0ATOM 6721 0 HOH 2315 -9. 941 -7. 450 -16. 220 1. 00 38. 78 0
ATOM 6722 0 HOH 2316 -3. 578 -10. 400 - 9. 914 1. 00 47. 52 0ATOM 6722 0 HOH 2316 -3. 578 -10. 400-9. 914 1. 00 47. 52 0
ATOM 6723 0 HOH 2317 - 21. 301 -50. 593 -16. 386 1. , 00 53. 71 0ATOM 6723 0 HOH 2317-21. 301 -50. 593 -16. 386 1., 00 53. 71 0
ATOM 6724 0 HOH 2318 -25. 499 -44. 603 一 1. 138 1. 00 55. 18 0 ATOM 6724 0 HOH 2318 -25. 499 -44. 603 One 1. 138 1. 00 55. 18 0
END 、  END,
【0 0 9 2】  [0 0 9 2]
例 4 Example 4
a)複合体モデルの作成 a) Creation of complex model
例 3で得られた結晶構造解析結果を用いて、 コンピューターグラフィクス上で、 Escherichia coli UPRTaseの暫結合部位に CMPをフィットさせ、 結合様式を示 す複合体モデルを構築した。 Maestro (Schrodinger社製）上のドッキングプログラ ム Glideを用いて、 Escherichia coli UPRTaseに IMPをドッキングさせ、 既知の 相互作用様式をもつ UMPの配座を選択後、 UMPより 8A以内のアミノ酸残基に対し MMGBSA (Molecular Mechanics-Generalized Born Surface Area)計算し、 Eschericnia coli UPRTaseと UMPの結合様式モデルを構築させた。 次に UMPを CMPにそのまま 置き換えて、 CMPより 8 A以内のァミノ酸残基に対し、丽 GBSA計算を行い、 UPRTase と CMPとの複合体モデルを作成した。以降の変異型酵素のデザインにはこのモデル を用いることとした。 Using the crystal structure analysis results obtained in Example 3, CMP was fitted to the temporary binding site of Escherichia coli UPRTase on computer graphics to construct a complex model showing the binding mode. Using docking program Glide on Maestro (Schrodinger), IMP is docked to Escherichia coli UPRTase, and UMP conformation with known interaction mode is selected. MMGBSA (Molecular Mechanics-Generalized Born Surface Area) was calculated and a binding mode model of Eschericnia coli UPRTase and UMP was constructed. Next, replace UMP with CMP and perform 丽 GBSA calculation for amino acid residues within 8 A of CMP. And a composite model of CMP was created. This model was used for the design of subsequent mutant enzymes.
この複合体モデルをよく観察し、シトシンとの親和性を増大させる変異を設計した。 この観察から、 まず、 シトシンのアミノ基の窒素原子から 7. 3Aの位置に α炭素 原子が存在する 205位グリシンを、該ァミノ基との親和性を上昇させるアミノ酸に 置換することが有効であると考えられた。またシトシンのピリミジン環 5位の炭素 原子） から 3. 8Αの位置に ε炭素原子が存在する 1 4 1位メチォニン、 シトシン のピリミジン環 6位の炭素原子から 4. 3 Αの位置に ]3炭素原子） が存在する 1 4 3 位ァラユンを、それぞれピリミジン環との親和性を上昇させるァミノ酸に置換する ことが有効であると考えられた。 We carefully observed this complex model and designed mutations that increase the affinity for cytosine. From this observation, it is effective to first replace the 205-position glycine, which has an α carbon atom at a position 7.3A from the nitrogen atom of the amino group of cytosine, with an amino acid that increases the affinity with the amino group. It was considered. The carbon atom at the 5th position of the pyrimidine ring of cytosine) is 3.8 carbon atoms from the ε carbon atom 1 4 1-position methionine, the pyrimidine ring of cytosine 4.3 carbon atoms from the 6th carbon atom position] It was considered effective to replace the 14 3 position arayun with an atom) with an amino acid that increases the affinity for the pyrimidine ring.
上記の 3つのァミノ酸残基の位置をよく観察し、置換後のァミノ酸としてそれぞ れ、 ァスパラギン酸.（G205D) 、 ロイシン （M141.L) 、'パリシ （A143V) を..選択して、 これら 3つのアミノ酸置換を有する変異型 Escherichia coli UPRTaseと CMPの複 - 合体モデルを、 CMPより 8 A以内のァミノ酸残基に対し MMGBSA計算を行って、 構 築した （図 2 ) 。  Carefully observe the positions of the above three amino acid residues, and select aspartic acid (G205D), leucine (M141.L), and 'parisi (A143V) as the amino acids after substitution. A mutant Escherichia coli UPRTase-CMP complex model with these three amino acid substitutions was constructed by performing MMGBSA calculations on amino acid residues within 8 A of CMP (Fig. 2).
【0 0 9 3】  [0 0 9 3]
CMPと変異型 UPRTaseの結合様式モデルでは 4位のァミノ基の水素原子と Gly207 のバックボーンのカルポニル基の酸素原子、 および、 3位の窒素と Ala209のパッ クボーンのアミド水素原子、 2位のカルボニル酸素と Gly210のアミド水素原子と の間に水素結合が生じている。  In the binding mode model of CMP and mutant UPRTase, the hydrogen atom of the 4-position amino acid, the oxygen atom of the backbone carbonyl group of Gly207, and the amide hydrogen atom of the 3-position nitrogen and Ala209 backbone, the 2-position carbonyl oxygen There is a hydrogen bond between the amide hydrogen atom of Gly210.
シトシン認識の鍵になる変異である Asp205とシトシンは、 4位ァミノ基の水素原 子と Aspの側鎖カルボン酸の酸素原子との間に静電相互作用で結合している。した がって、 Asp205は同じ負電荷をもつグルタミン酸でも相互作用できる。 Asp205 and cytosine, which are the key mutations in cytosine recognition, are bound by an electrostatic interaction between the hydrogen atom of the 4-position amino group and the oxygen atom of the side chain carboxylic acid of Asp. Therefore, Asp205 can interact with glutamic acid with the same negative charge.
CMPのピリミジン環は、 Leul41のメチル基との間で CH/ π相互作用で結合している。 CMPと CH/ π相互作用で結合するには、 Leul41がメチル基を持つ Ile、 Valでもよ いと考えられる。 さらに、 CMPの 5位、 6位の水素付近では、 Vall43との間に疎水 相互作用で結合していると考えられる。 この部位にはもともと空隙が少なく、 Val より嵩高いァミノ酸である Leu、 lieでは立体障害が生じる可能性がある。 The pyrimidine ring of CMP is bonded to the methyl group of Leul41 by CH / π interaction. In order to bond CMP with CH / π interaction, Lele41 may be Ile or Val having a methyl group. Furthermore, in the vicinity of hydrogen at the 5th and 6th positions of CMP, it is thought that it is bound to Vall43 by hydrophobic interaction. Leu and lie, which are originally amino acids with fewer voids and higher bulk than Val, may cause steric hindrance.
【0 0 9 4】  [0 0 9 4]
また、 CMPと野生型 UPRTaseの複合体構造解析より、 Tyr201は、 Asp208と水素結 合を作ることによって、 MetMlと共にピリミジン環をサンドイッチし、 シトシン 結合部位の一部を形成している。 この部位は Asp208と相互作用できる、 Lysや Arg でもよいと思われる。 From the structural analysis of the complex between CMP and wild-type UPRTase, Tyr201 forms a hydrogen bond with Asp208, thereby sandwiching the pyrimidine ring with MetMl to form part of the cytosine binding site. This site could be Lys or Arg, which can interact with Asp208.
【0 0 9 5】  [0 0 9 5]
また、 他の種の UPRTaseの構造解析より、 PRPPのリン酸基と相互作用すると知ら れている Argll2が B5 (5番目のベータストランド） と B6 ( 6番目のベータストラ ンド） の間の非常に運動性が高い、 フレキシブルループにある （EMBO J. (1998) 17： 3219 - 3232) 。 フレキシブルループの運動性を制限すれば、 Arg112と基質との親和 性が強められる可能性がある。 具体的には、 B6上にある Prol21を Proより嵩高い Leu, Ile、 Valなどの疎水アミノ酸に置換すれば、 近傍の A5 ( 5番目の αヘリ ックス） 上の Leul54や Alal50との疎水結合が強まるものと期待される。 また、 Prol21を Phe、 Tyr、 TrP、 Hisなどの芳香族アミノ酸に置換すれば、 CH/ π相互作 用によって、 B6と A5の親和性が高まると予想される。 From the structural analysis of other types of UPRTases, Argll2, which is known to interact with the phosphate group of PRPP, is B5 (5th beta-strand) and B6 (6th beta-strand). Is in a flexible loop (EMBO J. (1 9 98) 17: 3219-3232). Limiting the flexibility of the flexible loop may increase the affinity between Ar g 112 and the substrate. Specifically, if Prol21 on B6 is replaced with a hydrophobic amino acid such as Leu, Ile, or Val, which is bulkier than Pro, hydrophobic bonds with Leul54 and Alal50 on nearby A5 (5th α-helix) It is expected to strengthen. In addition, if Prol21 is substituted with an aromatic amino acid such as Phe, Tyr, Tr P or His, the affinity between B6 and A5 is expected to increase due to the CH / π interaction.
【0 0 9 6】  [0 0 9 6]
b)四量体モデルの作成 b) Creation of tetramer model
X線結晶構造解析の構造情報をもとにそれぞれの単量体同士の境界部分を含む四 量体モデルを Insight97によりグラフィクスで作成した （図 3 )。 グラフィックス 上の構造をよく観察し、単量体間の I和性を増大ざせる変異を設計した。 四量体ィ ンターフヱースに位置する（隣接する U P R T a s e単量体のいずれかの原子から' 5 A以内に構成原子が存在する） Arg36においては、 もう一方の二量体由来の Arg36' と距離的に近く、 静電的反発が生じていると思われる。 従ってこのアミノ 酸を、 電荷を持たず、 かつ立体障害がない程度の大きさのアミノ酸、 例えば Cys、' Ser、 Thr、 Met, Leu、 Ile、 Valなどに置換すると、 このような反発が除かれ、 四 量体構造の安定化が期待できる。 同じく、 Asp94においても同様の理由で静電的反 発が生じていると考えられ、 これらを電荷のない Gly、 Ser、 Thr、 Ala、 Leu、 Val、 Ile、 Tyr、 Phe、 Trpなどに置換すれば四量体構造が安定化する。 また四量体中の 静電的反発を除くだけではなく、積極的に四量体間の相互作用を強めることによつ ても、 同様の活性向上が期待できる。 例えば、 Ser46をさらに長鎖のアミノ酸、 た とえば Asnに置換すると、二量体を形成している'もう一方の単量体の E98， との間 に水素結合が生じ、 CPRTase活性向上に繫がると考えられる。  Based on the structural information of the X-ray crystal structure analysis, a tetramer model including the boundary between each monomer was created with graphics using Insight97 (Fig. 3). The structure on the graphics was closely observed, and mutations that increase the I-compatibility between monomers were designed. Arg36 located in the tetramer interface (there is a constituent atom within 5 A from any atom of the adjacent UPRT ase monomer) is distant from Arg36 from the other dimer. It seems that there is an electrostatic repulsion. Therefore, if this amino acid is substituted with an amino acid having no charge and no steric hindrance, such as Cys, 'Ser, Thr, Met, Leu, Ile, Val, etc., such repulsion is eliminated. Stabilization of the tetramer structure can be expected. Similarly, it is considered that electrostatic repulsion occurs in Asp94 for the same reason, and these are replaced by Gly, Ser, Thr, Ala, Leu, Val, Ile, Tyr, Phe, Trp, etc. without charge. For example, the tetramer structure is stabilized. In addition to eliminating electrostatic repulsion in the tetramer, a similar improvement in activity can be expected by actively strengthening the interaction between tetramers. For example, when Ser46 is further substituted with a longer chain amino acid, for example, Asn, a hydrogen bond is formed between E98 and the other monomer that forms the dimer, which improves CPRTase activity. It is thought that.
また、相手側の単量体に向かって伸びる) 3アームが構造上重要であると^えられる 1 中でも Trp66近傍のアミノ酸に変異を加えることにより CPRTase活性向上につ ながる可能性がある In addition, it is considered that the three arms (which extend toward the other monomer) are structurally important.1 Among them, mutation of an amino acid near Trp66 may lead to improved CPRTase activity.
【0 0 9 7】  [0 0 9 7]
例 5 Example 5
変異型酵素の取得とその評価 （その 1 ) Acquisition and evaluation of mutant enzymes (Part 1)
配列番号 1 5で表されるァミノ酸配列からなる Escherichia coliの U P R T a s eの 1 4 1番目のメチォニン残基を他のアミノ酸に置換することを目的に、配列 番号 1 6で表される塩基配列からなる Escherichia coliの U P R T a s eをコー ドする D N Aに基づき、配列番号 1 7で表される塩基配列からなるメチォ-ン残基 をコードする領域を任意の塩基 (nnn)に置換した D NA、 およぴ該塩基配列と相補 的な配列番号 1 8で表される塩基配列からなる D N Aを合成した。 【0098】 From the nucleotide sequence represented by SEQ ID NO: 16 for the purpose of substituting the 1st methionine residue of Escherichia coli UPRTase consisting of the amino acid sequence represented by SEQ ID NO: 15 with another amino acid. Based on the DNA encoding UPRTase of Escherichia coli, the DNA encoding the methion residue consisting of the base sequence represented by SEQ ID NO: 17 is substituted with an arbitrary base (nnn), and A DNA consisting of the base sequence represented by SEQ ID NO: 18 complementary to the base sequence was synthesized. [0098]
また、 201番目のチロシン残基を他のアミノ酸に置換することを目的に、上記 と同様に、該領域を任意の塩基に置換した配列番号 19で表される塩基配列からな る D N A、およぴ該塩基配列と相補的な配列番号 20で表される塩基配列からなる DN Aを合成した。  In addition, for the purpose of substituting the 201st tyrosine residue with another amino acid, as described above, a DNA comprising the base sequence represented by SEQ ID NO: 19 in which the region is substituted with an arbitrary base, and A DNA consisting of the base sequence represented by SEQ ID NO: 20 complementary to the base sequence was synthesized.
さらに、 プラスミド pEUPl上において、 UPRTa s e遺伝子の上流側に相当す る配列番号 21で表される塩基配列からなる D N A、およぴ下流側の逆鎖に相当す る配列番号 22で表される塩基配列からなる D N Aを合成した。  Furthermore, on the plasmid pEUPl, the DNA consisting of the base sequence represented by SEQ ID NO: 21 corresponding to the upstream side of the UPRTase gene and the base represented by SEQ ID NO: 22 corresponding to the reverse strand on the downstream side DNA consisting of sequences was synthesized.
【0099】  [0099]
配列番号 18および 21で表される塩基配列を有する DN A、配列番号 17およ ぴ 22で表される塩基配列を有する DNA、配列番号 20および 21で表される塩 基配列を有する DN A、並びに配列番号 19および 22で表される塩基配列を有す る DNAをそれぞれプライマーセットとして用レ、、 pEUPlプラスミド DNAを铸型 として、 Pyrobest DNAポリメラーゼ （タカラバイオ社製） を使用して、 それぞれ PCRを行った。  DNA having the base sequence represented by SEQ ID NOs: 18 and 21, DNA having the base sequence represented by SEQ ID NOs: 17 and 22, DNA having the base sequence represented by SEQ ID NOs: 20 and 21 PCR using Pyrobest DNA polymerase (manufactured by TAKARA BIO INC.) Using DNA having the nucleotide sequences represented by SEQ ID NOS: 19 and 22 as primer sets and pEUPl plasmid DNA as a saddle type, respectively. Went.
【0100】  [0100]
P C Rにより得られた約 0.5kb、 約 0.3kb、 約 0.7kb、 およぴ約 0. lkbの増幅産 物をァガロースゲル電気泳動し、 Qiagen Gel Extraction Kitを用いて抽出、 精製 した。  Amplified products of about 0.5 kb, about 0.3 kb, about 0.7 kb, and about 0.1 kb obtained by PCR were subjected to agarose gel electrophoresis, and extracted and purified using the Qiagen Gel Extraction Kit.
得られた約 0.5kbと約 0.3kbの増幅産物、および約 0.7kbと約 0. lkbの増幅産物 をそれぞれ混合し、 この 2種類の混合物をそれぞれ錶型として、配列番号 9および 10で表される塩基配列を有する DNAをプライマーセットとして用い、 PCRを 行った。 '  The obtained amplification products of about 0.5 kb and about 0.3 kb, and amplification products of about 0.7 kb and about 0.1 kb were mixed, respectively, and these two types of mixtures were expressed as SEQ ID NOs: 9 and 10, respectively. PCR was performed using a DNA having a base sequence as a primer set. '
【0101】  [0101]
上記 PC Rにより、それぞれ約 0.8kbの増幅 DNA断片が得られたので、該 DN A断片をァガロースゲル電気泳動した後、 Qiagen Gel Extraction Kitを用いて該 DNA断片を抽出、精製した後、 それぞれ^ RIおよび^ Iで切断し、上記と同 様の方法で精製した。  The above-mentioned PCR yielded amplified DNA fragments of approximately 0.8 kb. The DNA fragment was subjected to agarose gel electrophoresis, extracted and purified using the Qiagen Gel Extraction Kit, and each of the DNA fragments was ^ RI. And it cut | disconnected by ^ I and refine | purified by the method similar to the above.
得られた DN A断片を、 同じく EcoRIおよび BamHIで切断した発現ベクター pTr c99Aとそれぞれ結合し、 該結合体を用いて Escherichia coli MC1000 AcodA Ac dd ApyrG::Km株を形質転換した。  The obtained DNA fragment was ligated to the expression vector pTr c99A, which was also cleaved with EcoRI and BamHI, and Escherichia coli MC1000 AcodA Acdd ApyrG :: Km strain was transformed using the ligated product.
【0102】  [0102]
アンピシリン耐性を指標にしてそれぞれ形質転換体を選択し、該形質転換体を 5 0mg/lのシトシンと 100 μ g/mlのアンピシリンを含む M 9最少寒天培地上にレプリ 力したところ、それぞれ 1個のシングルコロニーが得られたので、 141番目のァ ミノ酸残基の置換体を Rl株、 201番目のアミノ酸残基の置換体を R2株と命名し た。 Each transformant was selected using ampicillin resistance as an indicator, and each transformant was replicated on M9 minimal agar medium containing 50 mg / l cytosine and 100 μg / ml ampicillin. Since the single colony was obtained, the 141st The substituted amino acid residue was named Rl strain, and the substituted amino acid residue at position 201 was named R2 strain.
R1および R2株が保持するプラスミド中の UPRTa s e構造遺伝子部分の塩基 配列を常法により決定したところ、 R1株では 141番目のアミノ酸残基が口イシ ンに、 205番目のアミノ酸残基がァスパラギン酸に置換した変異型 UP RT a s e (M141L G205D) をコードする DNA、 R2株では 201番目のアミノ酸残基がリ ジンに、 204番目のアミノ酸残基がロイシンに置換した変異型 UPRTa se (Υ 20 IK P204L) をコードする DN Aが見いだされた。  When the nucleotide sequence of the UPRTase structural gene in the plasmids held by R1 and R2 strains was determined by conventional methods, the 141st amino acid residue was the mouth isine and the 205th amino acid residue was aspartic acid in the R1 strain. DNA encoding mutant UPRTase (M141L G205D) substituted with, and in the R2 strain, the mutant UPRTase (Υ 20 IK) with the 201st amino acid residue replaced with lysine and the 204th amino acid residue replaced with leucine DN A encoding P204L) was found.
【0103】  [0103]
次に、上記で見いだされた' 4つのァミノ酸残基の置換変異を単独で有する変異型 UPRTa se (M141L、 G205D、 Y201K、 P204L) をコードする DNAを、 上記と同 様に置換したいアミノ酸に対応するコドンを有するプライマー DNAを用いた P CR法により取得した。 得られた変異型 UPRTa seをコードする DNAは、 そ れぞれ pTrc99Aと結合し、該結合体を用いて Escherichia coli MC1000 AcodA Δ cdd ApyrG::Km株を形質転換した。 '  Next, the DNA encoding the mutant UPRTase (M141L, G205D, Y201K, P204L) having the single substitution mutation of the four amino acid residues found above is replaced with the amino acid to be substituted as described above. It was obtained by the PCR method using a primer DNA having a corresponding codon. The obtained DNA encoding mutant UPRTase was each bound to pTrc99A, and Escherichia coli MC1000 AcodAΔcdd ApyrG :: Km strain was transformed with the conjugate. '
【0104】  [0104]
形質転換体を、 50mg/lのシトシンと 100 g/mlのアンピシリンを含む M 9最少 寒天培地上で培養したところ、 205番目のアミノ酸残基がァスパラギン酸に置換 した変異体 （G2Q5D) のみが生育した。  When transformants were cultured on M9 minimal agar medium containing 50 mg / l cytosine and 100 g / ml ampicillin, only the mutant (G2Q5D) in which the 205th amino acid residue was replaced with aspartic acid grew. did.
次に R1および R2株が有する変異型 U PRTa seの CMP生成活性を測定する ことを目的に、ヒスチジンタグを付加した変異型酵素を以下のようにして取得した。  Next, for the purpose of measuring the CMP generation activity of the mutant UPRTase possessed by the R1 and R2 strains, a mutant enzyme added with a histidine tag was obtained as follows.
【0105】  [0105]
配列番号 16で表される、 UPRTa se遺伝子の 5， 末端領域の塩基配列に相 当する、配列番号 23で表される塩基配列からなる D N A、および配列番号 22で 表される塩基配列からなる DNAをプライマーセットとして用い、 R1が保持する プラスミド DNA、 R2株が保持するプラスミド DNAおよび pEUPlをそれぞれ铸 型として、 Pyrobest DNAポリメラーゼを用いて P C Rを行った。  The DNA consisting of the base sequence represented by SEQ ID NO: 23 and the DNA consisting of the base sequence represented by SEQ ID NO: 22 corresponding to the base sequence of the 5 and terminal regions of the UPRTase gene represented by SEQ ID NO: 16 As a primer set, PCR was performed using Pyrobest DNA polymerase using plasmid DNA retained by R1, plasmid DNA retained by the R2 strain, and pEUPl as a template.
【0106】  [0106]
得られた約 0.8kbの增幅： DNA断片をそれぞれァガロースゲル電気泳動した後、 Qiagen Gel Extraction Kitを用いて精製し、 Sphlおよび Hindi IIで切断した。 上記で得られた DNA断片を、 同じく Sphlおよび. Hindlllで切断した発現べク ター pQE82L (Qiagen社製） とそれぞれ結合し、 該結合体を用いて Escherichia co li DH5a株を形質転換し、 形質転換体をアンピシリン耐性を指標に選択した。 The resulting gain of about 0.8 kb: DNA fragments were each subjected to agarose gel electrophoresis, purified using Qiagen Gel Extraction Kit, and cleaved with Sphl and Hindi II. The DNA fragment obtained above, also Sphl and. Click downy expression was cut with Hindlll coater pQE 82 L (Qiagen Inc.) and respectively bonded, the Escherichia co li DH5 a strain was transformed with the conjugate The transformants were selected using ampicillin resistance as an indicator.
【0107】  [0107]
得られた 3種の形質転換体をそれぞれ 100 μ g/mlのアンピシリンを含む L B培 地で 30°Cにてー晚種培養した後、得られた培養物を lOO^g/mlのアンピシリンを 含む Teriff ic培地 〔パクトトリプトン 1 、 酵母エキス 2½、 グリセ口ール 4ml を水 1Lに含み、 pH 7. 2に調整した培地〕に 1%植菌して 30°Cにて 8時間培養した。 IPTGを終濃度 1裏 ol/lになるように添加し、 さらに 6時間培養した後、 培養物を 遠心分離して菌体を取得した。 The three transformants obtained were each cultured in an LB medium containing 100 μg / ml ampicillin at 30 ° C, and the resulting culture was treated with lOO ^ g / ml ampicillin. 1% inoculated Terfic medium (Pactotryptone 1, Yeast extract 2½, Glyceal 4ml in 1L of water and adjusted to pH 7.2) and cultured at 30 ° C for 8 hours . IPTG was added to a final concentration of 1 ol / l and further cultured for 6 hours, and then the culture was centrifuged to obtain bacterial cells.
【0 1 0 8】  [0 1 0 8]
該菌体を超音波破砕して粗酵素液を調製し、 HiTrap Chelating HP Couluim (Ph armacia社製） を用いてヒスチジンタグが付加した酵素をそれぞれ精製した。 該精製酵素を反応液 〔50贿。1/1 ト リス塩酸 (PH 7. 5)、 5讓 ol/l リン酸一力リゥ ム、 5囊 ol/l 塩化マグネシウム、 5mmol/l シトシン、 1細 ol/l グアノシン 5， 一ト リリン酸、 1. 5醒 ol/l PRPP〕 に添加し、 31°Cにて反応を行い、 生成する CM Pを高 速液体ク口マトグラフィー (HPLC)により定量した。 タンパク濃度は Protein Assay Kit (Pharmacia社製)を用いて測定した。 The bacterial cells were sonicated to prepare a crude enzyme solution, and the enzyme added with the histidine tag was purified using HiTrap Chelating HP Couluim (Pharmacia). The purified enzyme was used as a reaction solution [50 mm. 1/1 Tris hydrochloric acid ( PH 7.5), 5 讓 ol / l monolithic phosphate, 5 囊 ol / l magnesium chloride, 5mmol / l cytosine, 1 fine ol / l guanosine 5, monotrilin acid, 1. added to 5 s Awakening ol / l PRPP], the reaction was carried out at 31 ° C, it was quantified by the resulting CM P high speed performance liquid inlet Mato chromatography (HPLC). Protein concentration was measured using Protein Assay Kit (Pharmacia).
【0 1 0 9】  [0 1 0 9]
—方、 UM P生成活性については、 ヒスチジンタグを付加していない酵素の発現 株 (宿主は Escherichia coli DH5 株) より調製した粗酵素抽出液を反応液 [50m mol/1 トリス塩酸 (pH 7. 5)、 5mmol/l リン酸一力リゥム、 5讓 ol/l塩化マグネシゥ ム、 5mno]yi ゥラシル、 lmmol/1 グアノシン 5， 一トリ リン酸、 1. 5mmol/l. PRPP3 に添加し、 31°Cにて反応を行い、生成する UMPを H P L Cにより定量した。結果 を表 2に示す。  -On the other hand, for UMP production activity, the crude enzyme extract prepared from an enzyme-expressing strain without the histidine tag (the host is Escherichia coli DH5) was used as the reaction solution [50 mMol / 1 Tris-HCl (pH 7. 5), 5mmol / l monolithic phosphate, 5 讓 ol / l magnesium chloride, 5mno] yi uracil, lmmol / 1 guanosine 5, monotriphosphoric acid, 1.5mmol / l. Add to PRPP3, 31 ° The reaction was conducted at C, and the produced UMP was quantified by HPLC. The results are shown in Table 2.
【0 1 1 0】  [0 1 1 0]
【表 2】  [Table 2]
表 2  Table 2
Figure imgf000220_0001
*1 活性測定宿主； DH5 a株
Figure imgf000220_0001
* 1 Activity measurement host; DH5 a strain
*2生育試験宿主； MC1000 A codA A cdd ApyrG: :Km株  * 2 Growth test host; MC1000 A codA A cdd ApyrG:: Km strain
nt；測定せず nt; not measured
【0 1 1 1】 [0 1 1 1]
表 2から明らかなように、野生型酵素では CM P生成活性は検出されなかったの に対し、 R1および R2株が生産する変異型酵素（Y201K P204Lおよび M141L G205D) では明らかな生成活性が認められた。  As is clear from Table 2, no CMP-producing activity was detected with the wild-type enzyme, whereas the mutant-type enzymes produced by the R1 and R2 strains (Y201K P204L and M141L G205D) showed clear productive activity. It was.
また CM P生成活性の上昇に応じて本来の活性である UM P生成活性は顕著に 減少していたことから、ゥラシルからシトシンへの基質特異性の変換が起きている ことが明らかとなった。  In addition, since the UMP production activity, which is the original activity, decreased significantly with the increase in CMP production activity, it became clear that the substrate specificity conversion from uracil to cytosine occurred.
【0 1 1 2】  [0 1 1 2]
4種の単独変異体の活性を比較すると G205D変異体のみがシトシン添力 Π M9最少 培地での生育が見られ、 UMP生成活性が大幅に減少していたことから、 G205D変 異が特にシトシンの認識に重要な役割を果たしていると考えられた。  Comparing the activities of the four single mutants, only the G205D mutant had cytosine strength Π growth in M9 minimal medium, and the UMP production activity was greatly reduced. It was thought to play an important role in recognition.
【0 1 1 3】  [0 1 1 3]
例 6 Example 6
変異型酵素の取得とその評価 （その 2 ) Acquisition and evaluation of mutant enzymes (Part 2)
例 5で得られた M141Lのアミノ酸置換変異を有する UPRTaseをコードする DNA をベクター PTrc99Aに連結したプラスミドを铸型として、配列番号 1 6で表される 塩基配列を有する D N Aおよび配列番号 2 3で表される塩基配列からなる D N A をプライマ一セットとして用いて PCRを行い、例' 5と同様にして M141Lのアミノ酸 置換変異を有する UPRTaseをコードする DNAが pQE82Lに違結したプラスミドを得 た。 、 Using the plasmid obtained by ligating the DNA encoding UPRTase having the amino acid substitution mutation of M141L obtained in Example 5 to the vector P Trc99A as a saddle, the DNA having the base sequence represented by SEQ ID NO: 16 and SEQ ID NO: 23 PCR was carried out using DNA consisting of the nucleotide sequence represented as a primer set, and a plasmid in which DNA encoding UPRTase having an M141L amino acid substitution mutation was linked to pQE82L was obtained in the same manner as in Example '5. ,
【0 1 1 4】  [0 1 1 4]
得られたプラスミドを铸型として、例 5と同様に 205番目のアミノ酸残基に対応 するコドンにグルタミン酸をコードするコドンを有するプライマー D NAを用い た P C Rを行ない、 141番目のアミノ酸残基がロイシンに、 205番目のグリシンが グルタミン酸に置換した変異型 UPRTase (M141L G205E)をコードする DNA断片を取 得した。 '  Using the resulting plasmid as a saddle type, PCR was performed using a primer DNA having a codon encoding glutamic acid at the codon corresponding to the 205th amino acid residue as in Example 5, and the 141st amino acid residue was leucine. In addition, a DNA fragment encoding a mutant UPRTase (M141L G205E) in which the 205th glycine was replaced with glutamic acid was obtained. '
【0 1 1 5】  [0 1 1 5]
該 D N A断片を Sphlおよび Hindlllで切断し PQE82 Lと連結し、 141番目のアミ ノ酸残基がロイシンに、 205番目のグリシンがグルタミン酸に置換した変異型 UPRTase (M141L G205E)をヒスチジンタグが付加した状態で発現するプラスミドを 取得した。 該変異型 UPRTase (M1411 G205E)を発現するプラスミドを用いて Escherichia coli DH5 株を形質転換し、 形質転換体をアンピシリン耐性を指標に選択した。 上記で得られた変異型 UPRTase (M141L G205E)を発現する形質転換体およぴ例 5 で得られた変異型 UPRTase (M141L G205D)を発現する形質転換体を用いて例 5と同 様の手順により、それぞれヒスチジンタグが付加した変異型 UPRTase (M141L G205E) およぴ変異型 UPRTase (M141L G205D)を精製した。 The DNA fragment was ligated with cleaved with Sphl and Hindlll P QE82 L, 141 th amino acid residue is leucine, 205th glycine histidine tag added variants UPRTase substituted with glutamic acid (M141L G205E) Plasmids that were expressed in this state were obtained. Escherichia coli DH5 strain was transformed with a plasmid expressing the mutant UPRTase (M1411 G205E), and the transformant was selected using ampicillin resistance as an index. The same procedure as in Example 5 using the transformant expressing the mutant UPRTase (M141L G205E) obtained above and the transformant expressing the mutant UPRTase (M141L G205D) obtained in Example 5 As a result, a mutant UPRTase (M141L G205E) and a mutant UPRTase (M141L G205D) each having a histidine tag added thereto were purified.
【0 1 1 6】  [0 1 1 6]
該精製酵素を反応液 〔5 0 mmol/l トリス塩酸 (pH 7 . 5 ) 、 1 0廳 ol/l塩 化マグネシウム、 10mmol/l シトシン、 1讓 ol/l グアノシン 5 ' -トリリン酸、 3 mmol/1 PRPP] に添加し、 3 2 °Cにて反応を行い、 生成する CMPを高速液体クロマ トグラフィー（HPLC)により定量した。 タンパク質濃度は、 Protein assay kit (Pharmacia社）を用いて測定した。 結果を表 3に示す。  The purified enzyme was added to the reaction solution [50 mmol / l Tris-HCl (pH 7.5), 10 5ol / l magnesium chloride, 10mmol / l cytosine, 1 讓 ol / l guanosine 5'-triphosphate, 3mmol / 1 PRPP], reacted at 32 ° C, and the resulting CMP was quantified by high performance liquid chromatography (HPLC). The protein concentration was measured using a protein assay kit (Pharmacia). The results are shown in Table 3.
【0 1 1 7】  [0 1 1 7]
【表 3】  [Table 3]
表 3 · Table 3
Figure imgf000222_0001
Figure imgf000222_0001
【0 1 1 8】  [0 1 1 8]
表 3から明らかなように、 205番目のアミノ酸がグルタミン酸に置換した変異型 UPRTase (M141L G205E)でも、 205番目のアミノ酸がァスパラギン酸に置換した変異 型 UPRTase (M141L G205D)と同様に、 明らかな CMP生成活性が認められた。  As can be seen from Table 3, the mutated UPRTase (M141L G205E) in which the 205th amino acid was replaced with glutamic acid, as well as the mutated UPRTase (M141L G205D) in which the 205th amino acid was replaced with aspartic acid, showed a clear CMP. Production activity was observed.
【0 1 1 9】  [0 1 1 9]
例 7 Example 7
変異型酵素の取得とその評価 （その 3 ) Acquisition and evaluation of mutant enzymes (Part 3)
例 5で得られた G205Dのァミノ酸置換変異を有する UPRTaseをコードする DNA をベクター pTrc99Aに連結したプラスミドを錶型として、配列番号 1 6で表される 塩基配列を有する D N Aおよび配列番号 2 3で表される塩基配列からなる D N A をプライマーセットとして用いて PCRを行い、例 5と同様にして G205Dのアミノ酸 置換変異を有する UPRTaseをコードする DNAが pQE82Lに連結したプラスミドを得 た。  Using the plasmid obtained by ligating the DNA encoding UPRTase having the amino acid substitution mutation of G205D obtained in Example 5 to the vector pTrc99A as a saddle, the DNA having the base sequence represented by SEQ ID NO: 16 and SEQ ID NO: 23 PCR was performed using DNA consisting of the nucleotide sequence represented as a primer set, and a plasmid in which a DNA encoding UPRTase having an amino acid substitution mutation of G205D was linked to pQE82L was obtained in the same manner as in Example 5.
該変異型 UPRTase (G205D)を発現するプラスミドを用いて Escherichia coli DH5 α株を形質転換し、 形質転換体をアンピシリン耐性を指標に選択した。  Escherichia coli DH5α strain was transformed with the plasmid expressing the mutant UPRTase (G205D), and the transformant was selected using ampicillin resistance as an index.
上記で得られた変異型 UPRTase (G205D)を発現する形質転換体およぴ例 5で得ら れた変異型 UPRTase (M141L G205D)を発現する形質転換体を用いて例 5と同様の手 順により、 それぞれヒスチジンタグが付 !raした変異型 UPRTase(G205D)および変異 型 UPRTase (M141L G205D)を精製した。 The same procedure as in Example 5 was performed using the transformant expressing the mutant UPRTase (G205D) obtained above and the transformant expressing the mutant UPRTase (M141L G205D) obtained in Example 5. According to the sequence, a mutant UPRTase (G205D) and a mutant UPRTase (M141L G205D) each tagged with a histidine tag were purified.
該精製酵素を反応液 〔50腿。1/1 トリス塩酸 (pH 7. 5) 、 10 mmol/l塩化 マグネシウム、 4腕 ol/l シトシン、 1腿 ol/l グアノシン 5， -トリリン酸、 1.5 mmol/l PRPP) に添加し、 32 °Cにて反応を行い、 生成する CMPを高速液体クロマ トグラフィー (HPLC)により定量した。 タンパク質濃度は、 Protein assay kit (Pharmacia社）を用いて測定した。 結果を表 4に示す。  Reaction solution of the purified enzyme [50 thighs. 1/1 Tris HCl (pH 7.5), 10 mmol / l magnesium chloride, 4 arm ol / l cytosine, 1 thigh ol / l guanosine 5, -triphosphate, 1.5 mmol / l PRPP), 32 ° The reaction was conducted at C, and the resulting CMP was quantified by high performance liquid chromatography (HPLC). The protein concentration was measured using a protein assay kit (Pharmacia). The results are shown in Table 4.
【0120】  [0120]
【表 4】  [Table 4]
表 4 Table 4
Figure imgf000223_0001
Figure imgf000223_0001
【0121】  [0121]
表 4から明らかなように、 205番目のアミノ酸のァスパラギン酸への置換のみを 有する変異型 UPRTase(G205D)も、 141番目のアミノ酸のロイシンへの置換およ ぴ 205番目のアミノ酸のァスパラギン酸への置換を有する変異型 UPRTase (M141L G205D)と同様に、 明らかな CMP生成活性を有することがわかった。  As is clear from Table 4, the mutant UPRTase (G205D), which has only the substitution of the 205th amino acid with aspartic acid, also replaced the 141st amino acid with leucine and the 205th amino acid with aspartic acid. Similar to the mutant UPRTase with substitution (M141L G205D), it was found to have clear CMP-generating activity.
【0122】  [0122]
例 8 Example 8
活性上昇変異酵素の取得とその評価 Acquisition and evaluation of activity-enhancing mutant enzymes
例 5で取得した R2株が保持するプラスミド D N Aを铸型とし、 配列番号 21で 表される塩基配列からなる DNA、および配列番号 22で表される塩基配列からな る DN Aをプライマーセットとして用いて、 Recombinant Taq DNAポリメラーゼ The plasmid DNA retained in the R2 strain obtained in Example 5 is of a saddle type, and DNA consisting of the base sequence represented by SEQ ID NO: 21 and DNA consisting of the base sequence represented by SEQ ID NO: 22 are used as a primer set. Recombinant Taq DNA polymerase
(タカラバイオ社製） を使用して、 0.3mmol/l MgCl2の共存下でエラープローン P CRを行った。 (Takara Bio Inc.) was used to perform error-prone PCR in the presence of 0.3 mmol / l MgCl 2 .
【0123】  [0123]
得られた約 0.8kbの増幅 DNA断片をァガロースゲル電気泳動した後、 Qiagen Gel Extraction Kitを用いて精製した後、 EcoRIおよび BamHIで切断した。 .  The obtained amplified DNA fragment of about 0.8 kb was subjected to agarose gel electrophoresis, purified using Qiagen Gel Extraction Kit, and cleaved with EcoRI and BamHI. .
該 DNA断片を、 同じく EcoRIおよび BamHIで切断した発現べクター pTrc99Aと結 合し、得られた結合体を用いて Escherichia coli MC1000 AcodA Acdd ApyrG:： Km株を形質転換した。 The DNA fragment was ligated with an expression vector pTrc99A, which was also cleaved with EcoRI and BamHI, and Escherichia coli MC1000 AcodA Acdd ApyrG :: Km strain was transformed with the resulting conjugate.
【0124】  [0124]
アンピシリン耐性を指標に形質転換体を選択し、 得られた形質転換体を 7mg/l の 5-フルォロシトシンまたは 7mg/lの 2, 5, 6 -トリアミノ 4 -ヒドロキシピリミジン を含む M 9最少寒天培地 （シトシン 50mg/Lと 100μ g/mlのアンピシリンを含む） 上に約 15000株ずつそれぞれレプリカして生育を調べた。 Transformants were selected for ampicillin resistance as a marker, 2 of 5 Furuoroshitoshin or 7 mg / l of the resulting transformant 7m g / l, 5, 6 - triamino 4 - hydroxypyrimidine About 15000 strains were each replicated on M9 minimal agar medium (containing cytosine 50 mg / L and 100 μg / ml ampicillin) and examined for growth.
その結果、 5-フルォロシトシンを含むプレート上で 2株 （FC35-1、 FC35- 2と命 名） 、 2, 5，6-トリアミノ 4 -ヒドロキシピリミジンを含むプレート上で 1株 （TA35- 1と命名） がコロニーを形成した。 As a result, two strains on plates containing 5-Furuoroshitoshin (FC35-1, FC35- 2 and naming), 2, 5, 6 - triamino 4 - 1 strain on plates containing hydroxypyrimidine (TA35- 1 named ) Formed colonies.
【0 1 2 5】  [0 1 2 5]
FC35- 1、 FC35- 2および TA35 - 1株よりそれぞれプラスミド DN Aを抽出し、 UP RT a se構造遺伝子部分の塩基配列を決定したところ、 FC35-1株が保持する変異 型酵素遺伝子は 1 0 2番目のアミノ酸残基がシスティン、 1 9 8番目のアミノ酸残 基がグリシンに、 FC35- 2株が保持する変異型酵素遺伝子は 94番目のアミノ酸残 基がチロシンに、 TA35- 1株が保持する変異型酵素遺伝子は 3 6番目のアミノ酸残 基がシスティンに、 1 9 8番目のアミノ酸残基がグリシンにそれぞれ置換した酵素 をコードしていた。 ―  When plasmid DNA was extracted from FC35-1, FC35-2 and TA35-1 strains and the nucleotide sequence of the UP RTase structural gene was determined, the mutant enzyme gene retained by FC35-1 strain was 10 The second amino acid residue is cysteine, the 198th amino acid residue is glycine, and the mutant enzyme gene retained by the FC35-2 strain has the 94th amino acid residue in tyrosine and the TA35-1 strain. The mutant enzyme gene encoded an enzyme in which the 36th amino acid residue was replaced with cysteine and the 1980th amino acid residue was replaced with glycine. -
【0 1 2 [0 1 2
6】 6]
また、該プ ラスミ ド D NAを用い て Escherich ia coll DH5 aを形質転
Figure imgf000224_0001
換して得ら れた 3種の形質転換体を lOO g/mlのアンピシリ 'ンを含む LB培地にて培養後、培 養物から粗酵素抽出液を調製して CMP生成活性を測定した。 結果を表 5に示す。 In addition, Escherichia coll DH5a was transformed with the plasmid DNA.
Figure imgf000224_0001
The three transformants obtained by conversion were cultured in an LB medium containing lOO g / ml ampicillin, and then a crude enzyme extract was prepared from the culture, and the CMP production activity was measured. The results are shown in Table 5.
【0 1 2 7】 、  [0 1 2 7],
【表 5】 '  [Table 5] '
表 5 Table 5
【0128】 [0128]
表 5から明らかなように、シトシン ナログである 5-フルォロシトシンまたは 2, 5, 6 -トリアミノ 4-ヒドロキシピリミジンに対する耐性を指標として取得した 3株 As is clear from Table 5, three strains obtained using resistance to the cytosine analog 5-fluorocytosine or 2,5,6-triamino 4-hydroxypyrimidine as an index
(FC35- 1、 FC35 - 2、 TA35-1) の生産する UP RT a se変異酵素には、 錶型とした 変異酵素が有する 2個のアミノ酸残基の置換変異 (M141L G205D)に加えて、 新たに 1または 2個のアミノ酸残基の置換変異が見いだされ、該変異酵素の CMP生成活 性は鎵型とした変異酵素発現株と比較して 1.8から 40倍に上昇していた。 In addition to the substitution mutation (M141L G205D) of the two amino acid residues of the mutated enzyme, the UP RTase mutant enzyme produced by (FC35-1, FC35-2, TA35-1) A new substitution mutation of 1 or 2 amino acid residues was found, and the CMP activity of the mutant enzyme was increased 1.8 to 40 times compared to the mutant enzyme-expressing strain.
【0129】  [0129]
例 9 Example 9
部位特異的変異による活性上昇変異酵素の取得と評価 Acquisition and evaluation of enzyme with increased activity by site-directed mutagenesis
Escherichia coli由来の UPRT a. s eのホモロジ一モデルを、 Bacillus cald olyticus由来の UPRT a s eの UMP複合体構造 （PDBコード 1I5E) を鎳型 とし、 プログラム Insight97によって作成した。  An UPRT a.
次にプログラム CHARMM22の分子力場を用い、 エネルギー極小化させた UMP結 合体モデルを作成した。 該モデルを基に、 M1 L G205D変異酵素の CMP複合体モ デルを作成し、 エネルギー極小化を行つた。 この複合体モデルでは、 CMPの H5/ H6付近に空隙が見られたことから、 この空隙を埋めるために 143番目のァラ- ン残基をパリン、 ロイシン、イソロイシンなどの嵩高い疎水性アミノ酸に置換する ことにより CM Pとの結合の上昇が期待された。 Next, using the molecular force field of the program CHARMM22, we created a UMP conjugate model with minimized energy. Based on this model, a CMP complex model of M1 LG 2 05D mutant enzyme was created to minimize energy. In this complex model, a gap was found near H5 / H6 in CMP. To fill this gap, the 143rd alanine residue was replaced with a bulky hydrophobic amino acid such as palin, leucine, or isoleucine. By replacing, it was expected that binding to CMP would increase.
【0130】  [0130]
そこで、部位特異的変異導入により 143番目のァラニン残基をパリンに置換す る目的で、配列番号 16で表される塩基配列に基づき、ァラニン残基をコードする コドン (GCA)をバリン残基をコードするコドン (GTT)に置換した塩基配列（配列番号 24で表される塩基配列） を有する D'NA、およぴ該塩基配列と相補的な相捕配列 (配列番号 25で表される塩基配列） 力 らなる DNAを合成した。  Therefore, for the purpose of substituting the 143rd alanine residue with palin by site-directed mutagenesis, the codon (GCA) encoding the alanine residue was changed to the valine residue based on the base sequence represented by SEQ ID NO: 16. D'NA having a base sequence (base sequence represented by SEQ ID NO: 24) substituted with a coding codon (GTT), and a complementary sequence complementary to the base sequence (base represented by SEQ ID NO: 25) Sequence) DNA consisting of force was synthesized.
【0131】  [0131]
配列番号 25および 21で表される塩基配列からなる DNA、並びに配列番号 2 4および 22で表される塩基配列からなる DNAをそれぞれプライマーセットと して用い、 TA35 1株が保持するプラスミド DNAを铸型として、 Pyrobest DNAポ リメ'ラーゼを使用して PCRを行った。 ' 上記 P C Rで得られた約 0.5kbおよび約 0.3kbの増幅 D N A断片産物をァガ口一 スゲル電気泳動した後、 精製した。  The DNA consisting of the nucleotide sequences represented by SEQ ID NOs: 25 and 21 and the DNA consisting of the nucleotide sequences represented by SEQ ID NOs: 24 and 22 were used as primer sets, respectively, and the plasmid DNA retained by the TA35 1 strain was selected. PCR was performed using Pyrobest DNA polymerase as a mold. 'About 0.5 kb and about 0.3 kb amplified DNA fragment products obtained with the above PCR were purified by fuzzy mouth gel electrophoresis.
【0132】  [0132]
次に上記で得られた 2種の増幅 D N A断片を混合したものを鎵型とし、配列番号 21および 22で表される塩基配列からなる DNAをプライマーセットとして用 いて PC Rを行った。 上記 P C Rで得られた約 0.8kbの増幅 D N A断片をァガロースゲル電気^動し た後、 精製し、 EcoRIおよび BamHIで切断した。 Next, PCR was carried out using a mixture of the two types of amplified DNA fragments obtained above as a cage and using the DNA consisting of the nucleotide sequences represented by SEQ ID NOs: 21 and 22 as a primer set. The amplified DNA fragment of about 0.8 kb obtained by the above PCR was electrophoresed on agarose gel, purified, and cleaved with EcoRI and BamHI.
【0133】  [0133]
該 DN A断片を、 同じく EcoRIおよび BamHIで切断した発現べクター pTrc99Aと 結合し、 得られた結合産物を用いて Escherichia coli DH5 α株を形質転換し、 ァ ンピシリン耐性を指標にして形質転換.体を選択した。  The DNA fragment was ligated to the expression vector pTrc99A, which was also cleaved with EcoRI and BamHI, and the resulting ligation product was used to transform Escherichia coli DH5α strain, and transformed using ampicillin resistance as an indicator. Selected.
該形質転換体からプラスミド DN Αを抽出し、 UPRTa s e構造遺伝子部分の 塩基配列を常法により決定することにより、 143番目のァラニン残基がバリンに 置換した変異酵素をコードする D N Aが取得されていることを確認し、該プラスミ ド DNAを pA143VTA35 - 1と命名した。  By extracting plasmid DNΑ from the transformant and determining the nucleotide sequence of the UPRTase structural gene by a conventional method, DNA encoding a mutant enzyme in which the 143rd alanine residue is substituted with valine is obtained. The plasmid DNA was named pA143VTA35-1.
【0134】  [0134]
次に、該形質転換体を lOO/zg/mlのアンピシ.リンを含む LB培地で培養し、培養 物から粗酵素抽出液を調製して CMP生成活性を測定したところ、 もとの TA35 - 1 株が生産する変異酵素と比較して約 2.5倍比活性が上昇していた。  Next, the transformant was cultured in an LB medium containing lOO / zg / ml ampicillin. A crude enzyme extract was prepared from the culture and measured for CMP production activity. The original TA35-1 The specific activity increased about 2.5 times compared to the mutant enzyme produced by the strain.
【0135】  [0135]
例 10 Example 10
活性上昇変異酵素の取得とその評価 （その 2) Acquisition and evaluation of activity-enhancing mutant enzymes (Part 2)
例 9で取得した A143VTA35- 1株が保持するプラスミド DNAを铸型とし、 配列番号 21で表される塩基配列からなる DNA、および配列番号 22で表される 塩基配列からなる DNAをプライマーセットとして用いて、 Recombinant Taq DNA ポリメラーゼ （タカラバイオ社製） を使用して、 0. 3腿 ol/lMgCl2の共存下でェ ラープローン PC Rを行った。 The plasmid DNA retained by the A143VTA35-1 strain obtained in Example 9 is a saddle type, and the DNA comprising the base sequence represented by SEQ ID NO: 21 and the DNA comprising the base sequence represented by SEQ ID NO: 22 are used as a primer set. Te, using Recombinant Taq DNA polymerase (Takara Bio Inc.) was subjected to E Raab loan PC R in the presence of 0.3 thigh ol / lM g Cl 2.
【0136】  [0136]
例 8と同様に、 得られた約 0. 8 kbの増幅 DN A断片をァガロースゲル電気泳 動した後、 Qiagen Gel Extraction Kitを用いて精製した後、 EcoRIおよび BamHI で切断した。 ·  As in Example 8, the obtained amplified DNA fragment of about 0.8 kb was electrophoresed on an agarose gel, purified using Qiagen Gel Extraction Kit, and then cleaved with EcoRI and BamHI. ·
該 DNA断片を、 同じく EcoRIおよび BamHIで切断した発現ベクター pTrc99Aと 結合し、 得られた結合体を用いて Escherichia coli MC1000 AcodA Acdd Δ pyrG: : m株を形質転換した。  The DNA fragment was ligated with an expression vector pTrc99A that was also cleaved with EcoRI and BamHI, and Escherichia coli MC1000 AcodA AcddΔpyram :: m strain was transformed with the resulting conjugate.
【0137】  [0137]
' アンピシリン耐性を指 に^質転換体を選択し、得られた形質転換体を 40mg/l の 5 -フルォロシトシンまたは 50mg/lの 5 -メチルシトシンを含む M 9最少寒天 培地 （シトシン 40mg/Lと 100 xg/mlのアンピシリンを含む） 上に約 15000 株ずつそれぞれレプリカして生育を調べた。 その結果、 5-フルォロシトシンを含むプレート上で 1株 （FC - 5と命名） 、 5 -メ チルシトシンを含むプレート上で 2株（MC- 8、 MC-21と命名） がコロニーを形成 した。 '' Transformants were selected using ampicillin resistance as a finger, and the resulting transformants were selected from M9 minimal agar medium (containing cytosine 40 mg / L) containing 40 mg / l of 5-fluorocytosine or 50 mg / l of 5-methylcytosine. About 15000 strains were replicated on each of them and examined for growth. As a result, 1 strain (named FC-5) formed on the plate containing 5-fluorocytosine and 2 strains (named MC-8 and MC-21) formed on the plate containing 5-methylcytosine.
【0138】  [0138]
FC - 5、 MC - 8および MC- 21株よりそれぞれプラスミド DN Aを抽出し、 UPR Ta se構造遺伝子部分の塩基配列を決定したところ、 FC - 5株が保持する変異型 酵素遺伝子は 1 67番目のアミノ酸残基がァラニンに、 MC- 8株が保持する変異型 酵素遺伝子は 46番目のアミノ酸残基がァスパラギンに、 FC- 5株が保持する変異 型酵素遺伝子は 1.21番目のァミノ酸残基がィソロイシンに、それぞれ置換した酵 素をコードしていた。  When plasmid DNA was extracted from FC-5, MC-8 and MC-21 strains and the nucleotide sequence of the UPR Tase structural gene was determined, the mutant enzyme gene retained by FC-5 strain was 1 67th The mutated enzyme gene retained by MC-8 strain is the 46th amino acid residue is asparagine, and the mutated enzyme gene retained by the FC-5 strain is the 1.21st amino acid residue. Each of the isoleucines encoded a substituted enzyme.
【0139】  [0139]
また、 該プラスミド DN Aを用いて Escherichia coli DH5 αを形質転換して得 られた 3種の形質転換体を 100 /zg/mlのアンピシリンを含む LB培地にて培養 ' 後、培養物から粗酵素抽出液を調製して CMP生成活性を測定した。結果を表 6に 示す。 '  In addition, three transformants obtained by transforming Escherichia coli DH5α with the plasmid DNA were cultured in LB medium containing 100 / zg / ml ampicillin, and then the crude enzyme was removed from the culture. Extracts were prepared and the CMP production activity was measured. The results are shown in Table 6. '
【0140】  [0140]
【表 6】  [Table 6]
表 6 Table 6
Figure imgf000227_0001
Figure imgf000227_0001
【0141】  [0141]
表 6から明らかなように、 シトシンアナ口グである 5 -フルォロシトシンまた は 5-メチルシトシンに対する耐性を指標として取得した 3株 （FC - 5、 MC - 8およ び MC - 21) の生産する UP RT a se変異酵素には、 鎊型とした変異酵素が有す る 4個のアミノ酸残基の置換変異 (M141L、 G205D、 R36C、 E198G)に加えて、 新たに 1個のァミノ酸残基の置換変異が見いだされ、該変異酵素の CM P生成活性は铸型 とした変異酵素発現株と比較して 1. 3から 2. 3倍に上昇していた。 .  As is clear from Table 6, UP produced by 3 strains (FC-5, MC-8, and MC-21) acquired using resistance to cytosine analogs 5-fluorocytosine or 5-methylcytosine as an index. In addition to the 4 amino acid residue substitution mutations (M141L, G205D, R36C, E198G) of the mutated enzyme, the RTase mutant enzyme has a new amino acid residue. A substitution mutation was found, and the CMP production activity of the mutant enzyme increased from 1.3 to 2.3 times that of the mutant enzyme-expressing strain. .
【0142】  [0142]
例 11 Example 11
コリネバクテリゥム ·アンモニアゲネスを宿主とした CMP生産菌の造成 Construction of CMP producing bacteria using corynebacterium ammoniagenes as a host
塩基からヌクレオチドへのサルベージ合成を行う場合、 コリネパクテリゥム ·ァ ンモニァゲネスは PRPP供給能力が高く、工業化実績も豊富であることから、生 産反応の宿主として好適である。そこでコリネパクテリゥム 'アンモニアゲネスでWhen performing salvage synthesis from bases to nucleotides, Corynebacterium ammoniagenes has a high PRPP supply capacity and abundant industrialization results. Suitable as a production reaction host. So in Corynepacteria 'Ammonia Genes
UPRTa se変異酵素を発現するプラスミドを以下のようにして構築した。 A plasmid expressing the UPRTase mutant enzyme was constructed as follows.
【0143】  [0143]
例 9で取得したブラ、スミド pA143VTA35-lを铸型とし、 配列番号 26で表される 塩基配列からなる D N Aと配列番号 13で表される塩基配列からなる DNAをプ ライマーセットとして用いて pc Rを行った。  Using the Bra and Smid pA143VTA35-l obtained in Example 9 as a saddle type, using the DNA consisting of the base sequence represented by SEQ ID NO: 26 and the DNA consisting of the base sequence represented by SEQ ID NO: 13 as a primer set, pc R Went.
得られた約 0.7kbの増幅 DN A断片をァガロースゲル電気泳動後、 Qiagen Gel Extraction Kitを用いて精製し、 Sailおよび BamHIで切断した。  The obtained about 0.7 kb amplified DNA fragment was purified by agarose gel electrophoresis, purified using Qiagen Gel Extraction Kit, and cleaved with Sail and BamHI.
【0144】  [0144]
また、 コリネ型細菌で発現するプロモーター配列 p54-6 (GenBank AJ132582) を 含む、配列番号 27で表される塩基配列を有する DNA.断片を、プラスミドベクタ 一 PCS299P (特願平 11-110437： W000/63388) の Sse8387I- BamHI部位に挿入して取 得した発現ベクター PRI109を、 同じく Sailおよび BamHIで切断し、 上記した DN ' A断片と結合した。 得られた結合物を用いて Escherichia coli DH5o;株を形質転 換し、 カナマイシン耐性を指標として形質転換体を選択した。  In addition, a DNA fragment containing the nucleotide sequence represented by SEQ ID NO: 27, including the promoter sequence p54-6 (GenBank AJ132582) expressed in coryneform bacteria, was transformed into a plasmid vector PCS299P (Japanese Patent Application No. 11-110437: W000 / The expression vector PRI109 obtained by inserting it into the Sse8387I-BamHI site of (63388) was similarly cleaved with Sail and BamHI and ligated with the DN′A fragment described above. Escherichia coli DH5o; strain was transformed with the obtained binding product, and transformants were selected using kanamycin resistance as an index.
【0145】  [0145]
得られた形質転換体からプラスミド D N Aを抽出し、制限酵素切断解析および塩 基配列解析を行い、 目的とする変異型 UPRT a se遺伝子を含む約 0.7kbの DN A断片が挿入された構造を有するプラスミド DNAが取得されていることを確認 し、 該プラスミド DNAを PRA143VTA35-1と命名した。  Plasmid DNA is extracted from the resulting transformant, subjected to restriction enzyme cleavage analysis and base sequence analysis, and has a structure in which an approximately 0.7-kb DNA fragment containing the target mutant UPRTase gene is inserted. After confirming that the plasmid DNA was obtained, the plasmid DNA was named PRA143VTA35-1.
次に Corynebacterium ammoniagenes ATCC21170株にプラスミド pM143VTA35- 1 を、 電気穿孔法 〔FEMS Microbiology letters, 65, 299 (1989)3 により導入し、 カナマイシン耐性を指標にして形質転換体を選択し、得られた形質転換体をコリネ パクテリゥム ·アンモニアゲネス ATCC21170/pRA143VTA35 - 1と命名した。  Next, plasmid pM143VTA35-1 was introduced into Corynebacterium ammoniagenes ATCC21170 strain by electroporation [FEMS Microbiology letters, 65, 299 (1989) 3, and transformants were selected using kanamycin resistance as an indicator. The body was named Corynepactrium ammoniagenes ATCC21170 / pRA143VTA35-1.
【0146】  [0146]
例 12 Example 12
CMP生産試験 （1)  CMP production test (1)
例 1 1で取得した Corynebacterium ammoniagenes ATCC21170/pRA143VTA35-l株 を 20/zg/mlのカナマイシンを含む種培地 1 〔グルコース 50g、 ポリペプトン （日 本製薬社製） 10g、 イーストエキス 本製薬社製） 10g、 尿素 5g、 硫酸アンモ ユウム 5g、 リン酸ニ水素力リウム lg、 リン酸水素二力リウム 3g、 硫酸マグネシ ゥム ·七水和物 lg、 硫酸鉄 ·七水和物 10mg、 硫酸亜鉛 ·七水和物 10mg、 塩化力 ルシゥム'二水和物 lOOmg、硫酸マンガン '五水和物 20mg、 L一システィン 20mg、 D—パントテン酸カルシウム 10mg、 ビタミン 51^、 ニコチン酸 5mgおよびビォ チン 30 gを水 1Lに含み、 pH 7.2に調整した培地〕 が 10mlの入った大型試験管 に一白金耳接種し、 30°C、 24時間、 300 rpmにて往復振盪培養した。 7 071755 Example 1 Corynebacterium ammoniagenes ATCC21170 / pRA143VTA35-l strain obtained in 1 is seed medium 1 containing 20 / zg / ml kanamycin 1 [glucose 50 g, polypeptone (Nihon Pharmaceutical Co., Ltd.) 10 g, yeast extract 5 g of urea, 5 g of ammonium sulfate, 1 g of hydrogen dihydrogen phosphate, 3 g of dihydrogen hydrogen phosphate, 3 g of magnesium sulfate heptahydrate lg, iron sulfate heptahydrate 10 mg, zinc sulfate heptahydrate 10mg, Chlorochloric power Luccium dihydrate lOOmg, Manganese sulfate 'pentahydrate 20mg, L-cystine 20mg, D-calcium pantothenate 10mg, Vitamin 51 ^, Nicotinic acid 5mg and Biotin 30g in water 1L A large test tube containing 10 ml of medium adjusted to pH 7.2] was inoculated into one platinum loop, and reciprocally shaken at 30 ° C for 24 hours at 300 rpm. 7 071755
【0 1 4 7】 [0 1 4 7]
次に、得られた培養物 4mlを上記と伺一組成の液体培地が 250ml入った 2L容バ ッフル付三角フラスコに接種し、 30°C、 24時間、 190 rpmにて回転振盪培養した。 得られた培養物全量を種培地 2〔グルコース 100g、エルリッヒカツォエキス（極 東製薬工業社製） 10g、 ポリペプトン 10g、 リン酸二水素カリウム lg、 リン酸水 素二力リウム lg、 硫酸マグネシウム ·七水和物 lg、 硫酸鉄 ·七水和物 20rag、 硫 酸亜鉛 ·七水和物 10mg、 塩化カルシウム ·二水和物 100mg、 硫酸マンガン ·五水 和物 4. lmg、 ]3—ァラニン 15mg、 L一システィン 20mg、 ビォチン lOO ^ g、尿素 2g (別殺菌） および.ビタミン 5mg (別殺菌） を水 0. 9Lに含み、 pH7. 2に調整した 培地〕 が 2. 25L入った 5L容努酵槽に接種し、 32°C、 通気量 2. 5 L/分、 600 rpmに て、 濃ァンモユア水で pH6. 8に調整しつつ通気攪拌培養した。 Next, 4 ml of the obtained culture was inoculated into a 2 L baffle Erlenmeyer flask containing 250 ml of a liquid medium having the same composition as described above, and cultured with shaking at 30 ° C. for 24 hours at 190 rpm. The total amount of the obtained culture was mixed with seed medium 2 [glucose 100 g , Erlich Katzo extract (manufactured by Kyokuto Pharmaceutical Co., Ltd.) 10 g, polypeptone 10 g, potassium dihydrogen phosphate lg, hydrogen bisulfite phosphate lg, magnesium sulfate Heptahydrate lg, iron sulfate heptahydrate 20rag, zinc sulphate heptahydrate 10mg, calcium chloride dihydrate 100mg, manganese sulphate pentahydrate 4. lmg,] 3-alanine 15mg , L-cystine 20mg, biotin lOO ^ g, urea 2g (separately sterilized) and vitamin 5mg (separately sterilized) in 0.9L of water, adjusted to pH 7.2) 2.25L containing 25L The fermenter was inoculated and cultured at 32 ° C, with an aeration rate of 2.5 L / min, 600 rpm, and adjusted to pH 6.8 with concentrated aqueous solution while stirring.
【0 1 4 8】  [0 1 4 8]
培養液上清中のグルコースが消費された時点で培養液 250 mlを無菌的に採取し、 生産培地 〔グルコース 150g、 リン酸ニ水素力リウム 10g、 リン酸水素二力リウム 10g、 硫酸マグネシウム ·七水和物 5g、 硫酸鉄 ·七水和物 20mg、 硫酸亜鉛 ·七水 和物 10mg、塩化カルシウム ·二水和物 100mg、 硫酸マンガン ·五水和物 20mg、 硫 酸銅 '五水和物 5mg、 ニコチン酸 5mg、 β—ァラニン 15mg、 グルタミン酸 lg、 L 一システィン 20mg、 ピオチン 100 ^u g 尿素 2g (別殺菌） およびビタミン 5mgWhen glucose in the culture supernatant is consumed, 250 ml of the culture is aseptically collected, and the production medium [glucose 150 g , dihydrogen phosphate 10 g, dihydrogen phosphate 10 g, magnesium sulfate · Heptahydrate 5g, Iron sulfate heptahydrate 20mg, Zinc sulfate heptahydrate 10mg, Calcium chloride dihydrate 100mg, Manganese sulfate pentahydrate 20mg, Copper sulfate 'pentahydrate 5 mg , nicotinic acid 5 mg, β-alanin 15 mg, glutamic acid l g , L-cystine 20 mg, piotin 100 ^ ug urea 2 g (separately sterilized) and vitamin 5 mg
(別殺菌） を水 0. 9Lに含み、 pH6. 8に調整した培地〕 2. 25Lが入った 5L容発酵槽 に接種し、 32°C、 通気量 2. 5 L/分、 600rpmにて、 濃ァンモニァ水で pH6. 8に調整 しつつ通気攪拌培養した。 (Separate sterilized medium containing 0.9L of water and adjusted to pH 6.8) 2. Inoculate 5L fermenter containing 25L, 32 ° C, aeration rate 2.5 L / min, 600rpm The culture was aerated and stirred while adjusting the pH to 6.8 with concentrated ammonia water.
【0 1 4 9】  [0 1 4 9]
培養液上淸中のグルコースが消費された時点で、 培養物 40 mlを採取し 250ml 容マイクロジャー （エイブル社製、 BMJ-25) に入れ、 これにグルコース 5. 、 シ トシン 300mg、 サニゾール B- 50 120mgを添加し、 32°C、 通気量 20 ml/分、 1100 rpm にて、 4mol/l K0Hで pH7. 6に調整しつつ CM P生産反応を行った。 その結果、 反 応開始から 24時間で CM Pが 21. 5 g/L (58. 7讓 ol ）生成した。 このとき C D P , C T Pの副生はそれぞれ 1. 6ramol/l、 0ramol/lであり、 添加したシトシンから CM Pへの転換率は約 87%であった。 When the glucose in the culture medium is consumed, 40 ml of the culture is collected and placed in a 250 ml microjar (BMJ-25, manufactured by Able), and glucose 5., cytosine 300 mg, sanizol B- 50 120 mg was added, and the MP production reaction was performed while adjusting the pH to 7.6 with 4 mol / l K0H at 32 ° C, aeration rate of 20 ml / min, and 1100 rpm. As a result, 21.5 g / L (58.7 kgol) of CMP was produced 24 hours after the start of the reaction. At this time, by-products of CDP and CTP were 1.6 ramol / l and 0 ramol / l, respectively, and the conversion rate from added cytosine to CMP was about 87%.
【0 1 5 0】  [0 1 5 0]
例 1 3 Example 1 3
CM P生産試験 （2 )  CM P Production Test (2)
例 9で得られた Escherichia coli DH5 a /pA143VTA35 - 1株を 100 μ g/mlのアンピ シリンを含む L B培地が 10 ml入った大型試験管に一白金耳接種し、 30°C、 18時 間、 300 rpmにて往復振盪培養した。 次に、 得られた培養物 3mlを 100 g/mlのァ ンピシリンを含む L B培地が 300ml入った 2L容パッフル付三角フラスコに接種し、 30°C、 20時間、 190 rpmにて回転振盪培養した。 培養終了後、 培養物を遠心分離し て菌体を取得した。 Inoculate a large test tube containing 10 ml of LB medium containing 100 μg / ml ampicillin with the Escherichia coli DH5a / pA143VTA35-1 strain obtained in Example 9 at 30 ° C for 18 hours. And reciprocating shaking culture at 300 rpm. Next, 3 ml of the obtained culture was inoculated into a 2 L puffed Erlenmeyer flask containing 300 ml of LB medium containing 100 g / ml ampicillin. Rotating and shaking culture was performed at 30 ° C for 20 hours at 190 rpm. After completion of the culture, the culture was centrifuged to obtain bacterial cells.
【0 1 5 1】  [0 1 5 1]
一方、 Corynebacterium ammoniagenes ATCC21170株をカナマイシンを含まない 条件下で例 9と同じ方法で 5L容発酵槽にて培養した。 得られた培養物 40mlを 250ml容マイクロジャーに入れ、 これに上記で取得した Escherichia coli DH5 o; /pA143VTA35- 1株の菌体 6 OOmg (湿重量） 、 グルコース 4. 0g、 シトシン 400mg、 サニゾ一ル 50 120mgを添カ卩し、 32°C、 通気量 20 ml/分、 1100 rpmにて、 4mol/l K0Hで PH7. 6に調整しつつ CM P生産反応をおこなった。 その結果、 反応開始から 24時間で CM Pが 14g/L (40讓 ol/l)生成した。 On the other hand, Corynebacterium ammoniagenes ATCC21170 strain was cultured in a 5 L fermentor in the same manner as in Example 9 under the condition not containing kanamycin. The resulting cultures 40ml put into 250ml ml micro jars, which Escherichia coli DH5 acquired in the o; / pA14 3 VTA 35 - 1 strain of the bacterial cell 6 OOmg (wet weight), glucose 4. 0 g, cytosine 400mg and添Ka卩the Sanizo Ichiru 50 120 mg, 32 ° C, aeration rate 20 ml / min at 1100 rpm, was subjected to CM P production reaction while adjusting the P H7. 6 with 4 mol / l K0H. As a result, CMP was produced 14 g / L (40) ol / l) in 24 hours from the start of the reaction.
【0 1 5 2】  [0 1 5 2]
例 1 4 . . Example 1 4.
CTP生産試験 -CTP production test-
( 1 ) ォロット酸からの CTP生産 (1) CTP production from orotate
Eschericnia coli應294株に Sacc—nar一 omyces cerevis—iae—由来の  294 strains of Eschericnia coli derived from Sacc-nar omyces cerevis-iae
Choline— phosphate cytidyly丄 transferaseおよび Choline kinase逾" |k子と Choline—phosphate cytidyly 丄 transferase and Choline kinase 逾 "|
Escherichia coli由来の CTP synthase遺伝子を発現するプラスミド pCKG55を導入し た丽 294/pCKG55株 （特開平 5- 276974号公報、 FERM BP-3717) をアンピシリン 50mg/L を含む L培地 [パクトトリプトン （ディフコネ土製） 10g/L、酵母エキス （ディフコ社 製） 5g/L、 塩化ナトリウム 5g/Lを含み pHを 7. 2に調整した培地] 200：111の入った2し バッフル付き三角フラスコに接種し、 25°Cにて 24時間 220rpmにて回転振とう培養し た。 この培養液2 OIBIを、 グルコース 5g/ L (別殺菌） 、 ペプトン （極東製薬工業社 製） 5g/ L、 リン酸水素ニナトリウム 6g/ L、 リン酸二水素カリウム 3G/ L、 塩化 アンモ-ゥム lg/L、硫酸マグネシウム '七水和物 250mg/L (別殺菌） およぴビタ ミン B14mg/L (別殺菌） の組成からなる液体培地 （PH無調整） 2. 5Lの入った 5L容培 養槽に接種し、培養温度 28°C、攪拌 600rpn！、 通気量 2. 5L/minの培養条件下、 14%ァ ンモニァ水を用いて PH7. 0に調整しつつ培養を行った。 Strain 294 / pCKG55 (JP-A-5-276974, FERM BP-3717) into which the plasmid pCKG55 expressing the CTP synthase gene derived from Escherichia coli was introduced was added to L medium containing 50 mg / L of ampicillin [Pacttryptone (Difcone Earthen) 10g / L, yeast extract (Difco) 5g / L, sodium chloride 5g / L and adjusted to pH 7.2] 200: 111 in 2 inoculated into Erlenmeyer flask with baffle, The cells were cultured with shaking at 220 rpm for 24 hours at 25 ° C. This culture solution 2 OIBI, glucose 5g / L (separately sterilized), peptone (manufactured by Kyokuto Pharmaceutical Co., Ltd.) 5g / L, disodium hydrogen phosphate 6g / L, potassium dihydrogen phosphate 3G / L, ammonium chloride © beam lg / L, magnesium sulfate 'heptahydrate 250 meters g / L (separately sterilized) Oyopi vitamin B14mg / L liquid medium having the composition of (separately sterilized) (P H unadjusted) 2. 5 L of Inoculate the 5L culture tank, and culture temperature 28 ° C, stirring 600rpn! Cultivation was performed while adjusting the pH to 7.0 using 14% ammonia water under the culture conditions of aeration rate of 2.5 L / min.
【0 1 5 3】  [0 1 5 3]
上記種培養液の上清中のグルコースが消費された時点で、培養液を 250ml無菌的 に採取し、 グルコース 5g/L (別殺菌） 、 ペプトン （極東製薬工業社製） 5g/L、 リ ン酸水素ニナトリウム 6g/ L、 リン酸二水素カリウム 3g/ L、 塩化アンモニゥム lg/ L、 硫酸マグネシゥム ·七水和物 250mg/ L (別殺菌） およびビタミン Bl 4mg/L (別殺菌） ） の組成からなる液体培地 （pH無調整） 2. 5Lの入った 5L容培養槽に接 種し、培養温度 28°C、攪拌 600rpm、通気量 2. 5L/niiriの培養条件下、 14%アンモニ ァ水を用いて pH7. 0に調整しつつ培養を行った。 培養中、 培養 11時間目から 24時間目までの間、 グルコース 167g/L、 ぺプトン 167g/Lの組成からなるフィード液をぺリスタポンプにより 30ml/hの速度にて添カロ した。 When glucose in the supernatant of the seed culture solution is consumed, 250 ml of the culture solution is aseptically collected and glucose 5 g / L (separately sterilized), peptone (manufactured by Kyokuto Pharmaceutical Co., Ltd.) 5 g / L, Disodium hydrogen phosphate 6g / L, potassium dihydrogen phosphate 3g / L, ammonium chloride lg / L, magnesium sulfate heptahydrate 250mg / L (separate sterilization) and vitamin Bl 4mg / L (separate sterilization)) Liquid medium consisting of composition (no pH adjustment) 2. Inoculate in a 5L culture tank containing 5L, culture temperature 28 ° C, stirring 600rpm, aeration volume 2. 14% ammonia under 5L / niiri culture conditions Culturing was carried out while adjusting the pH to 7.0 with water. During the culture from 11 to 24 hours, a feed solution composed of glucose 167 g / L and peptone 167 g / L was added at a rate of 30 ml / h with a peristaltic pump.
【0 1 5 4】  [0 1 5 4]
例 1 1で得られたコリネバクテリゥム ·アンモニアゲネス ATCC21170株培'養液 500mlおよぴ Escherichia coli MM294/pCKG55株培養液 185mlをそれぞれ 2L容培養槽 に入れ、 グルコース 48 g、硫酸マグネシウム ·七水和物 6. 25g、 リン酸二水素カリ ゥム 40g、 キシレン 14ml、 ォロット酸 5gを添加し反応液とした。 この反応液を、 30°Cにて攪拌 800rpm、 通気量 0. 3L/minの条件下、 10mol/lの K0Hにて pHを 7. 4に保ち つつ CTP生産反応を行い、生成した CTPを HPLCにより定量した。 その結果、反応開始 から 20時間で CTPが 4. 0 g/L(7. 27廳 ol/l)生成した。 Example 1 Corynebacterium ammoniagenes ATCC21170 strain culture solution 500ml and Escherichia coli MM294 / pCKG55 strain culture solution 185ml obtained in 1 above were placed in a 2L culture tank, and glucose 48g, magnesium sulfate 6.25 g of hydrate, 40 g of dihydrogen phosphate, 14 ml of xylene and 5 g of forotic acid were added to prepare a reaction solution. This reaction solution was stirred at 30 ° C at 800 rpm and aeration rate of 0.3 L / min. CTP production reaction was carried out with 10 mol / l K0H while maintaining the pH at 7.4. Was quantified. As a result, 4.0 g / L (7.27 廳 ol / l) of CTP was produced 20 hours after the start of the reaction.
【0 1 5 5】.  [0 1 5 5].
( 2 ) シトシンからの CTP生産  (2) CTP production from cytosine
例 1 1と同様にコリネパクテリゥム ·アンモニアゲネス  Example 1 Corynepacteria ammoniagenes as in 1
ATCC21170/PRA143VTA35- 1株を培養し、上淸中のグルコースが消費された時点で培 養を終了した。 2L容培養槽にコリネバクテリゥム ·アンモニアゲネス Culturing ATCC21170 / P RA143VTA35- 1 strain was terminated culture when glucose above淸中was consumed. Corynebacterium ammoniagenes in 2L culture tank
ATCC21170/pM143VTA35- 1株の培養液 500ml、 グルコース 48 g、硫酸マグネシウム · 七水和物 6. 25g、 リン酸二水素カリウム 40g、 キシレン 14ml、 シトシン 5gを添加 し反応液とした。. この反応液を、 30°Cにて攪拌 800rpm、 通気量 0. 3L/minの条件下、 10mol/lの K0Hにて pHを 7. 4に保ちつつ CTP反応を行い、 生成した CTPを HPLCにより定 量した。 その結果、 反応開始から 20時間で CTPが 14. 0 g/L(25. 4ra ol/l)生成した。 【0 1 5 6】 ATCC21170 / pM143VTA35-1 strain culture solution 500 ml, glucose 48 g, magnesium sulfate heptahydrate 6.25 g, potassium dihydrogen phosphate 40 g, xylene 14 ml, and cytosine 5 g were added to prepare a reaction solution. This reaction solution was stirred at 30 ° C at 800 rpm and aeration rate 0.3 L / min, CTP reaction was performed with 10 mol / l K0H while maintaining pH 7.4, and the generated CTP was HPLC Quantified by As a result, 14.0 g / L (25.4 raol / l) of CTP was produced 20 hours after the start of the reaction. [0 1 5 6]
例 1 5 ' Example 1 5 '
C D P—コリン生産試験 C D P—Choline production test
例 1 1と同様にコリネバクテリゥム 'アンモユアゲネス ―  Example 1 Corynebacterium 'Amoyuagenes' as in 1
ATCC21170/pRA143VTA35-l株を培養し、 上清中のグルコースが消費された時点で 培養を終了した。 2L容培養槽にコリネパクテリゥム ·アンモニアゲネス . The ATCC21170 / pRA143VTA35-l strain was cultured, and the culture was terminated when the glucose in the supernatant was consumed. Corynepacteria ammoniagenes in a 2L culture tank.
ATCC21170/pRA143VTA35-l株の培養液 500ml、 Escherichia coli丽 294/pCKG55株 培養液 185ml、 グルコース 48 g 、 塩ィ匕コリン 8. 4g、 硫酸マグネシウム ·七水和物 6. 25g、 リン酸ニ水素力リウム 40g、 キシレン 14ml、 シトシン 5gを添加し、' 反応 液とした。この反応液を、 30°Cにて攪拌 800rpm、通気量 0. 3L/minの条件下、 10mol/l の K0Hにて pHを 7. 4に保ちつつ CDP-コリン生産反応を行い、生成した CDP-コリン を HPLCにより定量した。 その結果、 反応開始から 20時間で CDP-コリンが 0. 5 g/L (l. 02匪 ol/l)生成した。 ATCC21170 / pRA143VTA35-l Strain 500ml, Escherichia coli 294 / pCKG55 Strain 185ml, Glucose 48g, Chloride Choline 8.4g, Magnesium Sulphate Heptahydrate 6.25g, Dihydrogen Phosphate 40 g of lithium, 14 ml of xylene and 5 g of cytosine were added to obtain a reaction solution. This reaction solution was stirred at 30 ° C at 800 rpm and aeration rate of 0.3 L / min, and CDP-choline production reaction was carried out by maintaining the pH at 7.4 with 10 mol / l K0H. -Choline was quantified by HPLC. As a result, 0.5 g / L (l. 02 匪 ol / l) of CDP-choline was produced 20 hours after the start of the reaction.
【0 1 5 7】  [0 1 5 7]
例 1 6 CMP-シアル酸生産試験 Example 1 6 CMP-sialic acid production test
( 1 ) Escherichia coli由来 CMP-シアル酸シンターゼ発現株の調製 .  (1) Preparation of Escherichia coli-derived CMP-sialic acid synthase expression strain.
発現べクタ一 pTrS32 (FERM BP-5408)を Pstlおよび Hindlllで酵素消化し、 3. 5kbの DNA断片を回収し、 同様に ？10 (特開昭58—110600号公報）を Pstlおよひ ¾indIII で酵素消化し、 l. Okbの断片を回収した。 該 3. 5kbと l. Okbの断片を連結し、 4. 5kb の pTrS31を取得した。  Is the expression vector pTrS32 (FERM BP-5408) enzymatically digested with Pstl and Hindlll to recover a 3.5 kb DNA fragment? 10 (JP-A-58-110600) was enzymatically digested with Pstl and ¾indIII to recover l. Okb fragments. The 3.5 kb fragment and l. Okb fragment were ligated to obtain 4.5 kb pTrS31.
pTrS31を Clalおよび Pstlで酵素消化し得られた 3· 5kbの DNA断片と、 pPACl (FERM BP - 6054， WO 98/12343)を Clalおよび Pstlで酵素消化して得られた 2. 3kbの DNA断片 とを連結し、 5. 8kbの pNT22を取得した。  A 3.5 kb DNA fragment obtained by enzymatic digestion of pTrS31 with Clal and Pstl, and a 2.3 kb DNA fragment obtained by enzymatic digestion of pPACl (FERM BP-6054, WO 98/12343) with Clal and Pstl And 5.8 kb pNT22 was obtained.
【0 1 5 8】  [0 1 5 8]
配列番号 28および 29で表される塩基配列を有する合成 DNAを用いて、  Using synthetic DNA having the base sequences represented by SEQ ID NOs: 28 and 29,
Escherichia coli K235株 (ATCC1302.7)の染色体 DNA .より、 CMP-シアル酸シンター ゼ遺伝子 neuAを含む DNA断片を下記方法で増幅した。 A DNA fragment containing the CMP-sialic acid synthase gene neuA was amplified from the chromosomal DNA of Escherichia coli K235 (ATCC1302.7) by the following method.
上記合成 DNAをプライマーセットとして、 Pyrobest DNAポリメラーゼを用いて PCR を行った。 該 PCR反応液の 1/10量をァガロースゲル電気泳動し、 目的の断片が增 幅されていることを確認後、残りの反応液と等量の TE [10mmol/l Tris - HC1、 lmmol/1 EDTA ( H 8. 0) ]飽和フヱノール Zク口口ホルム（lvol/vol)を添加し、 混合した。 PCR was performed using Pyrobest DNA polymerase with the synthetic DNA as a primer set. 1/10 volume of the PCR reaction solution was subjected to agarose gel electrophoresis, and after confirming that the target fragment was amplified, the same amount of TE [10 mmol / l Tris-HC1, lmmol / 1 EDTA as the rest of the reaction liquid was used. (H 8.0)] Saturated phenol Z throat form (lvol / vol) was added and mixed.
【0 1 5 9】 [0 1 5 9]
該混合液を遠心分離後、得られた上層に 2倍容量の冷エタノールを加えて混合し、 - 80°Cに 30分間放置した。該溶液を遠心分離し DNAの沈殿を取得し、該 DNAの沈殿 を 20 1の TEに溶解した。 該溶解液 5 μ 1を用い、 DNAを制限酵素 Hindlllおよび BamH Iで切断し、 ァガロースゲル電気泳動により DNA断片を分離した後、 1. 3kbの 断片を回収した。 '  After centrifuging the mixture, the obtained upper layer was mixed with 2 volumes of cold ethanol and allowed to stand at −80 ° C. for 30 minutes. The solution was centrifuged to obtain a DNA precipitate, and the DNA precipitate was dissolved in 201 TE. Using 5 μl of the lysate, DNA was cleaved with restriction enzymes Hindlll and BamHI, and DNA fragments were separated by agarose gel electrophoresis, and then a 1.3 kb fragment was recovered. '
pBluescript Π SK (+) (ストラタジーン社製） 0. 2 μ §を制限酵素 Hindlllおよ ぴ BamHIで切断後、ァガロースゲル電気泳動により、 DNA断片を分離し、同様に 2. 9kb の DNA断片を回収した。 pBluescript Π SK (+) (Stratagene) was cleaved 0. 2 mu § with restriction enzymes Hindlll Oyo Pi BamHI, the Agarosugeru electrophoresis, the DNA fragments are separated, similarly 2. recover a DNA fragment of 9kb did.
【0 1 6 0】  [0 1 6 0]
該 1. 3kbおよび 2. 9kbの断片をライゲーシヨンキットを用いて、 16°Cで 16時間、 連結反応を行った。 該連結反応液を用いて Escherichia coli丽 522を公知の方法 に従って形質転換し、 得られた形質転換体を 50 g/mlのアンピシリンを含む LB 寒天培地に塗布後、 30°Cでー晚培養した。  Using the ligation kit, the fragments of 1.3 kb and 2.9 kb were subjected to ligation reaction for 16 hours at 16 ° C. Using this ligation reaction solution, Escherichia coli 522 was transformed according to a known method, and the obtained transformant was applied to an LB agar medium containing 50 g / ml ampicillin and cultured at 30 ° C. .
生育した形質転換体を 50 μ g/mlのアンピシリンを含む LB液体培地にて 30°Cで —晚培養して得られた培養物から、 クラボウ社製自動核酸分離装置 PI50を用いて プラスミドを抽出した。  Extract the plasmid from the grown transformant in an LB liquid medium containing 50 μg / ml ampicillin at 30 ° C using an automatic nucleic acid separator PI50 manufactured by Kurabo Industries. did.
【0 1 6 1】 得られたプラスミドに含まれる PCR増幅断片の塩基配列を常法により決定した ところ、 GenBank ACCESSION No. J05023に記載の Escherichia coli 由来の CMP - シアル酸シンターゼをコ一ドする neuAと同じ塩基配列であった。 [0 1 6 1] When the nucleotide sequence of the PCR amplified fragment contained in the obtained plasmid was determined by a conventional method, it was found to be the same nucleotide sequence as neuA that codes for Escherichia coli-derived CMP-sialic acid synthase described in GenBank ACCESSION No. J05023. It was.
該プラスミドを Cla Iおよび BamH Iで切断後、 ァガロースゲル電気泳動により DNA断片を分離し、 1. 3kbの DNA断片を回収した。  The plasmid was digested with Cla I and BamH I, and then the DNA fragments were separated by agarose gel electrophoresis to recover a 1.3 kb DNA fragment.
PNT22 0. 2 μ §を制限酵素 Cla Iおよぴ BamH Iで切断後、 ァガロースゲル電気泳 動により DNA断片を分離し、 同 に 5. 5kbの DNA断片を回収した。 After cutting the PNT22 0. 2 μ § with restriction enzymes Cla I Oyopi BamH I, the DNA fragments were separated by Agarosugeru electrophoresis movement, to recover a DNA fragment of 5. 5 kb in the same.
【0 1 6 2】  [0 1 6 2]
該 1. 3kbおよぴ 5. 5kbの断片をライゲーシヨンキットを用いて、 16°Cで 16時間、 連結反応を行った。 該連結反応液を用いて Escherichia coli厕 522を公知の方法 に従って形質転換し、形質転換体を 50 i g/nilのアンピシリンを含む LB寒天培地に 塗布後、 30°Cでー晚培養した ς Using the ligation kit, the fragments of 1.3 kb and 5.5 kb were subjected to ligation reaction for 16 hours at 16 ° C. The Escherichia coli厕522 was transformed according to a known method using the ligation reaction solution, after coating the transformants on LB agar medium containing 50 ig / nil of ampicillin and 30 ° C De晚culture ς
生育した形質転換体を 5ひ^ g/mlのアンピシリンを含む LB液体培地にて.30°Cで ー晚培養して得られた培養物から、 PI50を用いてプラスミドを抽出した。 該プラ スミドの構造を制限酵素消化によって確認し、 該プラスミドを pTA23と命名した。  Plasmids were extracted using PI50 from a culture obtained by subjecting the grown transformant to 晚 liquid culture at 30 ° C in LB liquid medium containing 5 mg / ml ampicillin. The plasmid structure was confirmed by restriction enzyme digestion and the plasmid was designated pTA23.
Escherichia coli應 522を pTA23を用いて再度形質転換し、 得られた形質転換 体を Escherichia coli ΝΜ522/ρΤΑ23と命名した。  Escherichia coli 522 was transformed again with pTA23, and the resulting transformant was named Escherichia coli ΝΜ522 / ρΤΑ23.
【0 1 6 3】  [0 1 6 3]
( 2 ) CMP-シアル酸生産試験  (2) CMP-sialic acid production test
一方、 Escherichia coli NM522/pTA23をアンピシリン 50 / g/Lを含む L培地レ クトトリプトン （ディフコ社製） 10g/L、 酵母エキス （ディフコ社製） 5g/L、 塩化 ナトリウム 5g/Lを含み pHを 7. 2に調整した培地] 200mlの入つた 2Lパッフル付き 三角フラスコに接種し、 25°Cにて 24時間 220rpmにて回転振とう培養した。 この培 養液 20mlを、 グルコース 5g/ L (別殺菌）、 ペプトン（極東製薬工業社製） 5g/ L、 リン酸水素ニナトリウム 6g/ L、 リン酸ニ水素力リゥム 3g/ L、塩化アンモニゥム lg/ L、 硫酸マグネシウム '七水和物 250mg/ L (別殺菌） およびビタミン Bl 4mg/LOn the other hand, Escherichia coli NM522 / pTA23 with L medium tryptotone (Difco) 10g / L containing ampicillin 50 / g / L, yeast extract (Difco) 5g / L, sodium chloride 5g / L, pH 7 2. Medium adjusted to 2] Inoculate 200 ml of 2 L puffed Erlenmeyer flask and culture at 25 ° C for 24 hours at 220 rpm with rotary shaking. This culture solution 20 ml, glucose 5 g / L (separately sterilized), peptone (Kyokuto Pharmaceutical Industries Co., Ltd.) 5 g / L, disodium hydrogen phosphate 6 g / L, dihydrogen phosphate force Riumu 3 g / L, chloride Ammonium lg / L, Magnesium sulfate heptahydrate 250 mg / L (disinfection) and vitamin Bl 4 mg / L
(別殺菌） の組成からなる液体培地 （pH無調整） 2. 5Lの入った 5L容培養槽に接種 し、培養温度 28°C、攪拌 600rpm、 通気量 2. 5L/minの培養条件下、 14%アンモニア 水を用いて pH7. 0に調整しつつ培養を行った。 (Independent sterilization) Liquid medium (pH unadjusted) 2. Inoculate 5L culture tank containing 5L, culture temperature 28 ° C, stirring 600rpm, aeration 2. Culture condition of 5L / min, Culturing was carried out while adjusting the pH to 7.0 with 14% aqueous ammonia.
上記種培養液の上清中のグルコースが消費された時点で、培養液を 250ml無菌的 に採取し、 グルコース 5g/L (別殺菌） 、 ペプトン （極東製薬工業社製） 5g/L、 リ ン酸水素ニナトリウム 6g/ L、 リン酸ニ水素力リウム 3g/ L、 塩化アンモニゥム lg/ L、 硫酸マグネシゥム '七水和物 250mg/ L (別殺菌） およびビタミン Bl 4mg/LWhen glucose in the supernatant of the seed culture solution is consumed, 250 ml of the culture solution is aseptically collected and glucose 5 g / L (separately sterilized), peptone (manufactured by Kyokuto Pharmaceutical Co., Ltd.) 5 g / L, phosphorus disodium hydrogen 6 g / L, dihydrogen phosphate forces potassium 3 g / L, chloride Anmoniumu lg / L, sulfuric acid Maguneshiumu 'heptahydrate 250m g / L (separately sterilized) and vitamin Bl 4 mg / L
(別殺菌） ） の組成からなる液体培地 （pH無調整） 2. 5Lの入った 5L容培養槽に接 種し、培養温度 28°C、 攪拌 600rpm、 通気量 2. 5L/minの培養条件下、 14%アンモニ ァ水を用いて pH7. 0に調整しつつ培養を行った。 培養中、 培養 11時間目から 24時間目までの間、 グルコース 167g/L、 ぺプトン 167g/Lの組成からなるブイ一ド液をぺリスタポンプにより 30ml/hの速度にて添加 した。 (Separate sterilization)) Liquid medium with the composition of (No pH adjustment) 2. Inoculate in a 5L culture tank containing 5L, culture temperature 28 ° C, stirring 600rpm, aeration volume 2.5L / min culture conditions Then, the culture was performed while adjusting the pH to 7.0 using 14% ammonia water. During the culturing, a brood solution having a composition of glucose 167 g / L and peptone 167 g / L was added by a peristaltic pump at a rate of 30 ml / h from the 11th to the 24th culture.
【0 1 6 4】  [0 1 6 4]
例 1 1と同様にコリネバクテリゥム ·アンモニアゲネス  Example 1 Corynebacterium ammoniagenes as in 1
ATCC21170/pM143VTA35 - 1株を培養し、上清中のグルコースが消費された時点で培 養を終了した。 2L容培養槽にコリネパクテリゥム ·アンモニアゲネス The ATCC21170 / pM143VTA35-1 strain was cultured, and the culture was terminated when the glucose in the supernatant was consumed. Corynepacteria ammoniagenes in 2L culture tank
ATCC21170/pRA143VTA35-l株の培養液 500mlと Escherichia coli丽 522/pTA23株の培 養液 185ml、 プラク トース 48 g 、硫酸マグネシウム '七水和物 6. 25g、 リン酸二水 素カリウム 40g、 キシレン 14ml、 シトシン 5g、 シァノレ酸 14 gを、添加した。 これら 混合液を、 30。Cにて攪拌 800rpm、 通気量 0. 3L/minの条件下、 lOmol/1の K0Hにて pH を 7. 4に保ちつつ CMP-シアル酸反応を行い.、 生成した CMP-シアル酸を ΗΡίάこより定 量した。 その結果、 反応開始から 20時間で CMP -シアル酸が 4. 5 g/L (7. 07膽 ol/l)生 成した。 産業上の利用可能性 ATCC21170 / pRA143VTA35-l strain 500 ml and Escherichia coli 5 2 2 / pTA 2 3 strain 185 ml, practose 48 g, magnesium sulfate heptahydrate 6.25 g, potassium dihydrogen phosphate 40 g, 14 ml of xylene, 5 g of cytosine and 14 g of cyanoleic acid were added. 30. CMP-sialic acid reaction was carried out while maintaining pH 7.4 with lOmol / 1 K0H under conditions of 800 rpm with aeration rate of 0.3 L / min under C at 800 rpm and the generated CMP-sialic acid from ΗΡίά Weighed. As a result, 4.5 g / L (7.07 ol / l) of CMP-sialic acid was produced 20 hours after the start of the reaction. Industrial applicability
【0 1 6 5】  [0 1 6 5]
本発明により、シトシンから CM Pを生成する活性を有する蛋白質を得ることが できる。 この蛋白質を用いて CMPを安価、 かつ効率よく生産することができる。 【配列表フリーテキスト】  According to the present invention, a protein having an activity of generating CMP from cytosine can be obtained. Using this protein, CMP can be produced inexpensively and efficiently. [Sequence Listing Free Text]
【0 1 6 6】  [0 1 6 6]
配列番号 1—人工配列の説明：変異蛋白質 SEQ ID NO: 1—Description of artificial sequence: mutant protein
配列番号 2—人工配列の説明：変異蛋白質 ' SEQ ID NO: 2—Description of artificial sequence: mutant protein '
配列番号 3—人工配列の説明：変異 D NA SEQ ID NO: 3—Description of artificial sequence: Mutant DNA
配列番号 4—人工配列の説明：変異 D N A ' SEQ ID NO: 4—Description of artificial sequence: mutation D N A '
配列番号 5—人工配列の説明：変異 D NA SEQ ID NO: 5—Description of artificial sequence: Mutant DNA
配列番号 7—人工配列の説明：合成 D N A SEQ ID NO: 7—Description of artificial sequence: synthetic DNA
配列番号 8—人工配列の説明：合成 D N A SEQ ID NO: 8—Description of artificial sequence: synthetic DNA
配列番号 1 0—人工配列の説明：合成 D N A SEQ ID NO: 1 0—Description of artificial sequence: synthetic DNA
配列番号 1 1—人工配列の説明：合成 D NA ' 配列番号 1 3—人工配列の説明：合成 D N A SEQ ID NO: 1 1—Description of artificial sequence: synthetic D NA 'SEQ ID NO: 1 3—Description of artificial sequence: synthetic D N A
配列番号 1 4—人工配列の説明：合成 D N A SEQ ID NO: 1 4—Description of artificial sequence: synthetic DNA
配列番号 1 7一人工配列の説明：合成 D N A SEQ ID NO: 1 7 Description of one artificial sequence: synthetic DNA
配列番号 1 8—人工配列の説明：合成 D NA SEQ ID NO: 1 8—Description of artificial sequence: synthetic DNA
配列番号 1 9一人工配列の説明：合成 D NA SEQ ID NO: 1 9 Description of one artificial sequence: synthetic DNA
配列番号 2 0一人工配列の説明：合成 D NA 配列番号 21一人工配列の説明 合成 DNA 配列番号 2 2一人工配列の説明 合成 DNA 配列番号 2 3一人工配列の説明 合成 DNASEQ ID NO: 20 Description of one artificial sequence: synthetic DNA SEQ ID NO: 21 Description of one artificial sequence Synthetic DNA SEQ ID NO: 2 2 Description of one artificial sequence Synthetic DNA SEQ ID NO: 2 3 Description of one artificial sequence Synthetic DNA
K列番号 2 4一人工配列の説明 合成 DNA 配列番号 2 5一人工配列の説明 合成 DNA 配列番号 2 6一人工配列の説明 合成 DNA 配列番号 2 8一人工配列の説明 合成 DNA 配列番号 2 9一人工配列の説明 合成 DNA 配列番号 3 0一人工配歹 Uの説明 変異蛋白質 配列番号 3 4一人工配列の説明 合成 DNA 配列番号 3 5一人工配列の説明 合 DNA 配列番号 3 6一人工配列の説明 合成 DNA 配列番号 3 7一人工配列の説明 合成 DNA 配列番号 3 8一人工配列の説明 変異蛋白質 K Column No. 2 4 Description of one artificial sequence Synthetic DNA SEQ ID No. 2 5 Description of one artificial sequence Synthetic DNA SEQ ID No. 2 6 Description of one artificial sequence Synthetic DNA SEQ ID No. 2 8 Description of one artificial sequence Synthetic DNA SEQ ID No. 2 9 One Description of artificial sequence Synthetic DNA SEQ ID NO: 3 0 Description of one artificial array U Mutant protein SEQ ID NO: 3 4 Description of one artificial sequence Synthetic DNA SEQ ID NO: 3 5 Description of one artificial sequence Combined DNA SEQ ID NO: 3 6 Description of one artificial sequence Synthetic DNA SEQ ID NO: 3 7 Description of one artificial sequence Synthetic DNA SEQ ID NO: 3 8 Description of one artificial sequence Mutant protein

Claims

請求の範囲 The scope of the claims
【請求項 1】 [Claim 1]
シトシンからシチジン 5， 一モノリン酸（CMP) を生成する活性を有する蛋白質 の製造方法であって、 下記工程を含む方法： A method for producing a protein having an activity of producing cytidine 5, monomonophosphate (CMP) from cytosine, comprising the following steps:
[I]ゥラシルからゥリジン 5' —モノリン酸 (UMP) を生成する活性を有する蛋 白質（UPRTa s e) の三次元構造情報の一部又は全体を用いてコンビユ^"タ上 で UPRTa s eにおける UMP結合部位に CMPを適合させて作成される UP RT a s eと CMPとの複合体モデルを安定化させる、 U P RT a s eのアミノ酸 配列におけるアミノ酸の欠失、 置換及び/又は付加を 1個以上選択する工程； [I] uracil from uracil 5 '— UMP binding in UPRTa se on the combination using part or all of the 3D structure information of protein (UPRTa se) with activity to generate monophosphate (UMP) Selecting one or more amino acid deletions, substitutions and / or additions in the amino acid sequence of UP RTase, which stabilizes the complex model of UP RTase and CMP created by adapting CMP to the site;
[ 2]工程 [1,]で選択された欠失、置換及ぴ Z又は付加を含む UPRTa s eの変異 蛋白質を製造する工程。 - 【請求項 2】 [2] A step of producing a UPRTase mutant protein comprising the deletion, substitution and Z or addition selected in step [1,]. -Claim 2
シトシンからシチジン 5' —モノリン酸（CMP) を生成する活性を有する蛋白質 の製造方法であって、 下記工程を含む方法： A method for producing a protein having an activity of producing cytidine 5′-monophosphate (CMP) from cytosine, comprising the following steps:
[I I]ゥラシノレからゥリジン 5' —モノリン酸（UMP) を生成する活性を有する 蛋白質（UPRTa s e)の三次元構造情報の一部又は全体を用いてコンピュータ 上で UPRTa s eにおける UMP結合部位に CMPを適合させて作成される U PRT a s eと CMPとの複合体モデルを安定化させる、 U P R T a s eのァミノ 酸配列におけるァミノ酸の欠失、 置換及び Z又は付加を 1個以上選択する工程； [II] Urachinole to Uridine 5'—CMP is applied to the UMP binding site in UPRTa se on the computer using part or all of the 3D structure information of protein (UPRTa se) that has the activity to generate monophosphate (UMP). Selecting one or more amino acid deletions, substitutions and Z or additions in the amino acid sequence of the UPRT ase that stabilize the U PRT ase and CMP complex model produced by adaptation;
[12]前記複合体モデルの一部又は全体を用いてコンピュータ上で作成される該 複合体の多量体モデルを安定ィヒさせる、 UPRTa s eのアミノ酸配列におけるァ ミノ酸の欠失、 置換及び/又は付加を 1個以上選択する工程； [12] Amino acid deletion, substitution and / or in the amino acid sequence of UPRTase, which stabilizes a multimeric model of the complex created on a computer using a part or all of the complex model Or selecting one or more additions;
[13]工程 [11]および [12]で選択された欠失、、置換及び Z又は付加を含む UP Ta s eの変異蛋白質を製造する工程。 [13] A step of producing a UP Ta s mutant protein comprising the deletion, substitution and Z or addition selected in the steps [11] and [12].
【請求項 3〗  [Claim 3]
請求項 1又は 2に記載の方法により得られる蛋白質。 A protein obtained by the method according to claim 1 or 2.
【請求項 4】  [Claim 4]
配列番号 15に記載のアミノ酸配列において、 1乃至数個のァミノ酸が欠失.、置換 及ぴ Z又は付加されているアミノ酸配列を有し、 In the amino acid sequence set forth in SEQ ID NO: 15, one to several amino acids have been deleted, substituted and Z or added to the amino acid sequence,
シトシンから CMPを生成する活性を有し、 かつ Has the activity of generating CMP from cytosine, and
下記ァミノ酸置換を 1個以上含む蛋白質： Proteins containing one or more of the following amino acid substitutions:
表 1に記載の三次元座標原子座標であらわされる配列番号 15に記載のァミノ酸 配列からなりかつゥラシルから UM Pを生成する活性を有する蛋白質（UPRTa s e)の三次元構造情報の一部又は全体を用いてコンピュータ上で作成される UP RT a s eと UMPとの複合体モデルにおいて、 U¼Pのピリミジン環 4位のォキ ソ基の酸素原子から 1 OAの範囲に構成原子が存在するアミノ酸の置換であって、 前記複合体モデルの UMPのォキソ基をァミノ基に変換することによりコンビュ ータ上で作成される UPRT a s eと CMPとの複合体モデルを安定ィヒさせるァ ミノ酸への置換。 Part or all of the three-dimensional structural information of a protein (UPRTase) comprising the amino acid sequence of SEQ ID NO: 15 represented by the three-dimensional coordinate atomic coordinates described in Table 1 and having the activity of generating UMP from uracil Created on a computer using In the complex model of RTase and UMP, substitution of an amino acid having a constituent atom in the range from the oxygen atom of the oxo group at the 4-position of the pyrimidine ring 4-position of U¼P to 1 OA, wherein UMP of the complex model Substitution with amino acid that stabilizes the complex model of UPRTase and CMP created on the converter by converting an oxo group to an amino group.
【請求項 5】  [Claim 5]
前記のァミノ酸置換が配列番号 15に記載のァミノ酸配列の 205位のグリシン の置換である請求項 4に記载の蛋白質。 5. The protein according to claim 4, wherein the amino acid substitution is a substitution of glycine at position 205 of the amino acid sequence shown in SEQ ID NO: 15.
【請求項 6】  [Claim 6]
前記のァミノ酸置換が配列番号 15に記載のァミノ酸配列の 205位のグリシン のァスパラギン酸又はグルタミン酸への置換である請求項 4に記載の蛋白質。 【請求項5. The protein according to claim 4, wherein the amino acid substitution is substitution of glycine at position 205 of the amino acid sequence shown in SEQ ID NO: 15 with aspartic acid or glutamic acid. Claim
7.1 7.1
前記のァミノ酸置換が配列番号 15に記載のァミノ酸配列の 201位のチロシン 及び 204位のプロリンの置換である請求項 4に記載の蛋白質。 5. The protein according to claim 4, wherein the amino acid substitution is substitution of tyrosine at position 201 and proline at position 204 of the amino acid sequence represented by SEQ ID NO: 15.
【請求項 8】  [Claim 8]
前記のアミノ酸置換が配列番号 15に記載のァミノ酸配列の 201位のチロシン のリジンへの置換及ぴ 204位のプロリンのロイシンへの置換である請求項 4に 記載の蛋白質。 5. The protein according to claim 4, wherein the amino acid substitution is substitution of tyrosine at position 201 with lysine and substitution of leucine with proline at position 204 in the amino acid sequence shown in SEQ ID NO: 15.
【請求項 9】  [Claim 9]
前記の UP RT a s eと UMPとの複合体モデルにおいて UMPを構成するいず れかの原子から 1 OAの範囲に構成原子が存在するアミノ酸の置換（ただし UMP のピリミジン環 4位のォキソ基の酸素原子から 1 OAの範囲に構成原子が存在す るアミノ酸の置換を除く）であって、前記の UPRT a s eと CMPとの複合体モ デルを安定化させるアミノ酸への置換を 1個以上含む請求項 4〜 8のいずれか一 項に記載の蛋白質。 ' In the complex model of UP RT ase and UMP described above, substitution of an amino acid having a constituent atom in the range of one OA to 1 OA from the atom constituting UMP (however, the oxygen of the oxo group at the 4-position of the pyrimidine ring of UMP) (1) excluding substitution of amino acids having a constituent atom in the range from 1 atom to 1 OA), and comprising at least one substitution with an amino acid that stabilizes the complex model of UPRTase and CMP. The protein according to any one of 4 to 8. '
【請求項 10】  [Claim 10]
表 1に記載の三次元座標原子座標であらわされる配列番号 15に記載のァミノ酸 配列からなりかつゥラシルから UM Pを生成する活性を有する蛋白質（U P R T a s e)の三次元構造情報の一部又は全体を用いてコンピュータ上で作成される UP RT a s eとホスホリポシルピロリン酸（P R P P ) との複合体モデルにおいて P RPPを構成するいずれかの原子から 1 OAの範囲に構成原子が存在するァミノ 酸の置換であって、該複合体モデルを安定化させるアミノ酸への置換を 1個以上含 む請求項 4〜 8のいずれ力一項に記載の蛋白質。 Part or all of the three-dimensional structural information of a protein (UPRT ase) comprising the amino acid sequence of SEQ ID NO: 15 represented by the three-dimensional coordinate atomic coordinates described in Table 1 and having the activity of generating UMP from uracil Replacement of amino acids in which a constituent atom exists in the range of 1 OA to any one of the constituents of PRPP in a complex model of UP RTase and phospholiposyl pyrophosphate (PRPP) created on a computer using The protein according to any one of claims 4 to 8, comprising at least one substitution with an amino acid that stabilizes the complex model.
【請求項 11】  [Claim 11]
前記の UP RT a s eと CMPとの複合体モデ^/の一部又は全体を用いてコンビ ユータ上で作成される複合体の多量体モデルにおいて、隣接する UP RT a s e単 量体のいずれかの原子から 5 A以内に構成原子が存在するアミノ酸 及ぴ隣接す る UPRTa s e単量体の 66位 Trpのいずれかの構成原子から 5 A以内に構成原 子が存在するアミノ酸からなる群から選択されるアミノ酸の置換であって、該多量 体モデルを安定化させるアミノ酸への置換 In a multimeric model of a complex created on a computer using a part or all of the complex model of UP RTase and CMP, the adjacent UP RTase unit Amino acids with constituent atoms within 5 A from any atom in the monomer and amino acids with constituent atoms within 5 A from any constituent atom of position 66 of the adjacent UPRTase monomer A substitution of an amino acid selected from the group consisting of: and an amino acid that stabilizes the multimeric model
を 1個以上含む請求項 4〜10のいずれか一項に記載の蛋白質。 The protein according to any one of claims 4 to 10, which comprises one or more of.
【請求項 12】 ' .  Claim 12.
シトシンからシチジン 5， 一モノリン酸 (CMP) を生成する活性を有する、 配列 番号 1、 2、 または 30で表されるアミノ酸配列を有する蛋白質。 A protein having an amino acid sequence represented by SEQ ID NO: 1, 2, or 30, which has an activity of producing cytidine 5, monomonophosphate (CMP) from cytosine.
【請求項 13】  [Claim 13]
配列番号 1、 2、 または 30で表されるアミノ酸配列において、 36番目、 94番 目、 102番目、 141番目、 143番目および 198番目のアミノ酸残基から選 ばれる 1以上のァミノ酸残基が他のァミノ酸残基に置換したァミノ酸配列を有し、 かつシトシンから CM Pを生成する活性を有する蛋白質。 In the amino acid sequence represented by SEQ ID NO: 1, 2, or 30, one or more amino acid residues selected from the 36th, 94th, 102th, 141st, 143rd and 198th amino acid residues A protein having an amino acid sequence substituted with the amino acid residue of and having an activity of generating CMP from cytosine.
【請求項 14】  [Claim 14]
36番目のアミノ酸残基がシスティン、 94番目のアミノ酸残基がチロシン、 .10 2番目のアミノ酸残基がシスティン、 141番目のアミノ酸残基がロイシン、 14 3番目のァミノ酸残基がバリン、または 198番目のァミノ酸残基がグリシンに置 換したアミノ酸配列を有する請求項 12記載の蛋白質。  36th amino acid residue is cysteine, 94th amino acid residue is tyrosine, 10th amino acid residue is cysteine, 141st amino acid residue is leucine, 14th 3rd amino acid residue is valine, or 13. The protein according to claim 12, which has an amino acid sequence in which the 198th amino acid residue is replaced with glycine.
【請求項 15】  [Claim 15]
配列番号 1、 2、 または 30で表されるアミノ酸配列において、 36番目、 46番 目、 94番目、 102番目、 121番目、 141番目、 143番目、 167番目お ょぴ 198番目のアミノ酸残基から選ばれる 1以上のアミノ酸残基が他のアミノ 酸残基に置換したアミノ酸配列を有し、かつシトシンから CMPを生成する活性を 有する蛋白質。 In the amino acid sequence represented by SEQ ID NO: 1, 2, or 30, from the amino acid residue at position 36, position 46, position 94, position 102, position 121, position 141, position 143, position 167, and position 198 A protein having an amino acid sequence in which one or more selected amino acid residues are substituted with other amino acid residues and having an activity of generating CMP from cytosine.
【請求項 16】 、  16.
請求項 12〜15のいずれか 1項に記載の蛋白質のアミノ酸配列において、 36番 目、 94番目、 102番目、 141番目、 143番目、 198番目、 20；1_番目、 204番目おょぴ 205番目以外のアミノ酸残基から選ばれる 1以上のアミノ酸 残基が他のアミノ酸残基に置換したアミノ酸配列を有し、かつシトシンから CMP を生成する活性を有する蛋白質。 .The amino acid sequence of the protein according to any one of claims 12 to 15, wherein the 36th, 94th, 102nd, 141st, 143rd, 198th, 20; 1_th, 204th op 205 A protein having an amino acid sequence in which one or more amino acid residues selected from amino acid residues other than the second amino acid residue are substituted with other amino acid residues, and having an activity of generating CMP from cytosine. .
【請求項 17】 [Claim 17]
請求項 12〜15のいずれか 1項に記載の蛋白質のアミノ酸配列において、 36番 目、 46番目、 94番目、 102番目、 121番目、 141番目、 143番目、 1 67番目、 198番目、 201番目、 204番目おょぴ 205番目以外のアミノ酸 残基から選ばれる 1以上のアミノ酸残基が他のアミノ酸残基に置換したアミノ酸 配列を有し、 かつシトシンから CMPを生成する活性を有する蛋白質。 The amino acid sequence of the protein according to any one of claims 12 to 15, wherein the 36th, 46th, 94th, 102th, 121st, 141st, 143rd, 167th, 198th, 201st A protein having an amino acid sequence in which one or more amino acid residues selected from amino acid residues other than the 204th and 205th amino acids are substituted with other amino acid residues, and having an activity of generating CMP from cytosine.
【請求項 18】 [Claim 18]
以下の [1] または [2] 記載の DNA。 DNA according to [1] or [2] below.
[1] 請求項 3〜1 7のいずれかに記載の蛋白質をコードする； DN A  [1] encodes the protein according to any one of claims 3 to 17; DN A
[ 2 ] 配列番号 3〜 5のいずれかで表される塩基配列を有する D N A  [2] DNA having the base sequence represented by any of SEQ ID NOs: 3 to 5
【請求項 19】  [Claim 19]
請求項 18に記載の DNAを含む組換え体 DNA。 A recombinant DNA comprising the DNA of claim 18.
【請求項 20】  [Claim 20]
請求項 19記載の組換え体 DN Aを保有する微生物。 A microorganism having the recombinant DNA according to claim 19.
【請求項 21】  [Claim 21]
微生物がエツシエリヒア属、コリネパクテリゥム属またはブレビパクテリゥム属に 属する微生物である、 請求項 20記載の微生物。 21. The microorganism according to claim 20, wherein the microorganism is a microorganism belonging to the genus Escherichia, Corynepacterum or Brevipacterium.
【請求項 22】  [Claim 22]
請求項 20または 21に記載の微生物の培養物または該培養物の処理物、シトシン、 リン酸基供与体およびエネルギー供与体を水性媒体中に存在せしめ、該媒体中に C MPを生成、蓄積させ、該媒体から CMPを採取することを特徴とする CMPの製 造法。 The microorganism culture or treated product of the culture according to claim 20 or 21, cytosine, phosphate group donor and energy donor are present in an aqueous medium, and CMP is produced and accumulated in the medium. A method for producing CMP, characterized in that CMP is collected from the medium.
【請求項 23】  [Claim 23]
請求項 20または 21に記載の微生物の培養物または該培養物の処理物、コリネバ クテリウム属に属する微生物の培養物または該培養物の処理物、シトシン、 リン酸 基供与体およびエネルギー供与体を水性媒体中に存在せしめ、該媒体中に CMPを 生成、 蓄積させ、 該媒体から CMPを採取することを特徴とする CMPの製造法。 【請求項 24】 22. The microorganism culture according to claim 20 or 21, or a treatment product of the culture, a culture of a microorganism belonging to the genus Corynebacterium or a treatment product of the culture, a cytosine, a phosphate donor and an energy donor. A method for producing CMP, characterized by being present in a medium, generating and accumulating CMP in the medium, and collecting the CMP from the medium. [Claim 24]
コリネバタテリゥム属に属する微生物がコリネバタテリゥム 'アンモニアゲネスで ある、 請求項 23記載の製造法。 24. The production method according to claim 23, wherein the microorganism belonging to the genus Corynebataterium is Corynebataterium 'ammoniagenes.
【請求項 2.5】 ，  [Claim 2.5]
請求項 20または 21に記載の微生物の培養物または該培養物の処理物、シトシン、 リン酸供与体およびエネルギー供与体を水性媒体中に存在せしめ、該媒体中に生成 する CMPを用いることを特徴とする、 有用物質の製造法。 22. A microorganism culture according to claim 20 or 21, or a processed product of the culture, cytosine, a phosphate donor and an energy donor are present in an aqueous medium, and CMP is used to produce the medium. And manufacturing method of useful substances.
PCT/JP2007/071755 2007-11-02 2007-11-02 Method for producing cytidine 5'-monophosphate WO2009057230A1 (en)

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Title
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