WO2009057021A3 - Photoacoustic imaging contrast agent and system for converting optical energy to in-band acoustic emission - Google Patents
Photoacoustic imaging contrast agent and system for converting optical energy to in-band acoustic emission Download PDFInfo
- Publication number
- WO2009057021A3 WO2009057021A3 PCT/IB2008/054392 IB2008054392W WO2009057021A3 WO 2009057021 A3 WO2009057021 A3 WO 2009057021A3 IB 2008054392 W IB2008054392 W IB 2008054392W WO 2009057021 A3 WO2009057021 A3 WO 2009057021A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- optical energy
- contrast agent
- nano
- phase change
- substance
- Prior art date
Links
- 239000002872 contrast media Substances 0.000 title abstract 5
- 230000003287 optical effect Effects 0.000 title abstract 3
- 238000003384 imaging method Methods 0.000 title 1
- 238000001704 evaporation Methods 0.000 abstract 3
- 239000000126 substance Substances 0.000 abstract 3
- 239000000463 material Substances 0.000 abstract 2
- 239000002105 nanoparticle Substances 0.000 abstract 2
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000010276 construction Methods 0.000 abstract 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002101 nanobubble Substances 0.000 abstract 1
- 238000012285 ultrasound imaging Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
- A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/48—Diagnostic techniques
- A61B8/481—Diagnostic techniques involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/225—Microparticles, microcapsules
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Medical Informatics (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Surgery (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Acoustics & Sound (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
Abstract
The present disclosure provides systems and methods related to contrast agents for photoacoustic and ultrasound imaging. A contrast agent includes a nanoparticle -based contrast medium that is adapted to absorb optical energy and to undergo a phase change upon absorption of a requisite level of optical energy, such phase change being effective to generate nano-bubbles and/or micro-bubbles that resonate at a frequency or in a frequency range. Various constructions of the PA contrast agent are provided including one substance droplets with both absorbing and evaporating capabilities, and multiple-component complexes of one substance with both absorbing and evaporating materials. Highly absorbing nano-particles (such as gold nano-rods) may be coated with an evaporating material. In addition, disclosed agents (including either one substance or multi-component complex) may be encapsulated or coated with an optically transparent and mechanically elastic shell that allows the droplet to expand and form stabilized nano- and/or microbubbles during phase change.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98399407P | 2007-10-31 | 2007-10-31 | |
US60/983,994 | 2007-10-31 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009057021A2 WO2009057021A2 (en) | 2009-05-07 |
WO2009057021A3 true WO2009057021A3 (en) | 2009-08-06 |
Family
ID=40344742
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2008/054392 WO2009057021A2 (en) | 2007-10-31 | 2008-10-24 | Photoacoustic imaging contrast agent and system for converting optical energy to in-band acoustic emission |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2009057021A2 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102724911B (en) * | 2009-10-16 | 2016-06-22 | 皇家飞利浦电子股份有限公司 | Active ultrasonic imaging based on photoacoustic contrast agent |
CN103379850B (en) | 2010-12-22 | 2015-11-25 | 皇家飞利浦电子股份有限公司 | The photoacoustic signal based on the contrast agent of microvesicle is used to strengthen |
KR101654675B1 (en) | 2014-02-03 | 2016-09-06 | 삼성메디슨 주식회사 | Method, apparatus and system for generating diagnostic image using photoacoustic material |
KR101665633B1 (en) * | 2015-04-15 | 2016-10-12 | 서강대학교 산학협력단 | System and method for diagnosing using photoacoustic/ultrasound contrast agent |
CN109998484B (en) * | 2019-02-27 | 2022-02-25 | 广东工业大学 | Multifunctional arthritis detection and treatment system and method |
KR102269497B1 (en) * | 2019-06-04 | 2021-06-25 | 서강대학교 산학협력단 | Size-variation bubble complex and Method for preparing the same |
EP3932295A1 (en) * | 2020-06-30 | 2022-01-05 | Universität Zürich | Optoacoustic tomography method of a living organism, 2d- or 3d opotacoustic images, 2d- or 3d blood flow and light fluence images and a photoabsorbing agent for the use in an optoacoustic method |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004068405A2 (en) * | 2003-01-25 | 2004-08-12 | Oraevsky Alexander A | High contrast optoacoustical imaging using nanoparticles |
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2008
- 2008-10-24 WO PCT/IB2008/054392 patent/WO2009057021A2/en active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004068405A2 (en) * | 2003-01-25 | 2004-08-12 | Oraevsky Alexander A | High contrast optoacoustical imaging using nanoparticles |
Non-Patent Citations (5)
Title |
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CONJUSTEAU A ET AL: "Metallic nanoparticles as optoacoustic contrast agents for medical imaging", PROCEEDINGS OF THE SPIE - THE INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING SPIE - THE INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING USA, vol. 6086, no. 1, 9 February 2006 (2006-02-09), pages 60860K - 1, XP002516820, ISSN: 0277-786X * |
COPLAND J A ET AL: "Bioconjugated gold nanoparticles as a molecular based contrast agent: implications for imaging of deep tumors using optoacoustic tomography", MOLECULAR IMAGING & BIOLOGY, ELSEVIER, vol. 6, no. 5, 1 September 2004 (2004-09-01), pages 341 - 349, XP004570390, ISSN: 1536-1632 * |
EGHTEDARI MOHAMMAD ET AL: "High sensitivity of in vivo detection of gold nanorods using a laser optoacoustic imaging system.", NANO LETTERS JUL 2007, vol. 7, no. 7, July 2007 (2007-07-01), pages 1914 - 1918, XP002516822, ISSN: 1530-6984 * |
KRAFFT M P ET AL: "Perfluorocarbons: life sciences and biomedical uses", JOURNAL OF POLYMER SCIENCE, PART A (POLYMER CHEMISTRY) WILEY USA, vol. 45, no. 7, 1 April 2007 (2007-04-01), pages 1185 - 1198, XP002516823, ISSN: 0887-624X * |
ORAEVSKY A A ET AL: "Enhancement of optoacoustic tissue contrast with absorbing nanoparticles", PROCEEDINGS OF THE SPIE - THE INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING SPIE-INT. SOC. OPT. ENG USA, vol. 4434, 2001, pages 60 - 69, XP002516821, ISSN: 0277-786X * |
Also Published As
Publication number | Publication date |
---|---|
WO2009057021A2 (en) | 2009-05-07 |
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