WO2009056212A1 - Compositions containing resveratrol and pectin - Google Patents
Compositions containing resveratrol and pectin Download PDFInfo
- Publication number
- WO2009056212A1 WO2009056212A1 PCT/EP2008/008561 EP2008008561W WO2009056212A1 WO 2009056212 A1 WO2009056212 A1 WO 2009056212A1 EP 2008008561 W EP2008008561 W EP 2008008561W WO 2009056212 A1 WO2009056212 A1 WO 2009056212A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- composition
- pectin
- fluidized
- resveratrol
- weight
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Definitions
- the present invention relates to compositions comprising resveratrol and pectin.
- the present invention further relates to a process for the manufacture of such compositions, and to their use in dietary supplements, pharmaceutical and personal care compositions.
- the present invention is also directed to the use of pectin for improving the flowability of a powder containing resveratrol.
- Resveratrol is a phytoalexin produced naturally by several plants when under attack by bacteria or fungi.
- Phytoalexins are antibacterial and anti-fungal chemicals produced by plants as a defense against infection by pathogens.
- beneficial health effects such as anti-cancer, antiviral, neuroprotective, anti-aging, anti-inflammatory and life- prolonging effects have been reported.
- resveratrol as used herein relates to resveratrol, whereas the carbon-carbon double bond may be trans or cis and includes cis/trans mixtures. Especially preferred for the purposes of the invention is (trans)-resveratrol.
- resveratrol as used herein encompasses synthetic resveratrol as well as natural extracts as well as concentrates obtained by chemically (especially enzymatically), thermally, physically and/or by UV radiation treated material.
- Resveratrol is usually obtainable as crystalline powder consisting of resveratrol needles (see Figure 1) which has a very poor flowability.
- the poor flowability renders the crystalline powder difficult for use in making tablets and other application forms that require the powder to be free flowing.
- compositions known in the art which have solved a similar problem are compositions of polysaccharides with compounds such as (-)-epigallocatechin gallate (WO 03/011339) and genistein (WO 2006/087164), where the flowability of the compounds was improved by the addition of a polysaccharide.
- (-)-Epigallocatechin gallate is water-soluble, whereas genistein is generally hardly or essentially not water-soluble.
- the process known in the art is not applicable to resveratrol. This process consists of fluidizing the crystals in a hot air flow and spraying on an aqueous pectin solution.
- the composition is in the form of a powder or granules.
- one or more resveratrol crystals are coated or partially coated with pectin.
- the coated or partially coated crystal or crystals are held (glued) together by pectin, which functions as a binder, to form a granule with appropriate size.
- the preferred particle size distribution of the composition of the present invention is as follows: at least 95 % of the particles have a size of ⁇ 1500 ⁇ m (preferred: ⁇ 1000 ⁇ m, more preferred ⁇ 850 ⁇ m), whereby at most 35% of the particles have a size of ⁇ 50 ⁇ m (preferred: ⁇ 100 ⁇ m, more preferred ⁇ 150 ⁇ m).
- particle size distribution of the composition of the present invention is as follows: at least 95% of the particles have a size in the range of from 10 ⁇ m to 1500 ⁇ m (preferred: in the range of from 10 ⁇ m to 1000 ⁇ m, more preferred in the range of from 10 ⁇ m to 850 ⁇ m), whereby at most 35% of the particles have a size in the range of from 10 ⁇ m to 50 ⁇ m (preferred: in the range of from 10 ⁇ m to 100 ⁇ m, more preferred in the range of from 10 ⁇ m to 150 ⁇ m).
- the composition according to the present invention has preferably a water activity of from 0.05 to 0.7, preferably of from 0.1 to 0.5, more preferably of from 0.2 to 0.5.
- the water activity is measured using a Novasina Thermoconstanter TH200 (Novasina AG, Zurich, Switzerland).
- the moisture content in the composition is in the range of from 0 to 6 weight-%, preferred from 0 to 3 weight-%, each based on the total weight of the composition.
- the used resveratrol crystals have needle dimensions within the following ranges:
- Pectin is a polysaccharide and described for example in the book entitled Industrial Gums, third edition, Academic Press, Inc., 1993, pages 257ff. as well as in EP-A 1 110 550.
- Pectins used in the present invention are generally commercially available and e.g. produced from citrus peel or apple (pomace). Other possible sources are sugarbeet, sunflower and mango.
- Preferred pectins to be used within the scope of the present invention are citrus pectins, which generally have lighter colour than apple pectins and, thus, do not contribute significant colour to the final product.
- high molecular weight pectin may be used.
- the term "high molecular weight pectin” as used herein denotes pectin having a molecular weight of more than about 300 kDalton.
- the preferred high molecular weight pectins are those having a molecular weight of from about 300 kDalton to about 400 kDalton, particularly 350 kDalton.
- pectins can be obtained as disclosed in US 6,143,337 the contents of which are incorporated herein by reference.
- the molecular weight is determined by size exclusion chromatography having a multi angle laser light scattering detector as described in US 6,143,337.
- pectins of higher molecular weight e.g.
- Pectins of such molecular weight can be obtained e.g. from Asteraceae plants, especially cichory and Jerusalem artichoke, see WO 99/03892. Fractions of the desired high molecular weight can be obtained from such pectins by membrane filtration, e.g. using polyethersulfone or composite regenerate cellulose membranes as supplied by Millipore Corporation, Bedford, MA 01730, USA, under the trade name Pellicon® Tangential Flow Filtration Cassettes.
- the pectin is used in an amount of from 0.1% to 15% by weight, more preferably from 0.5% to 7% by weight, most preferably from 1.5% to 5% by weight, each based on the total weight of the composition.
- the present invention relates to a process for the manufacture of the composition of the present invention.
- composition of this invention may be produced by any method known per se for the production of powders or granules. Preferred methods are fluidized-bed granulation, high- shear granulation, extrusion, spray-drying and wet granulation.
- Preferred methods are fluidized-bed granulation, high- shear granulation, extrusion, spray-drying and wet granulation.
- the present invention is also directed to process for the manufacture of a composition of the present invention by those methods.
- composition of the present invention by spray-drying it is convenient to prepare a slurry of all components in a solvent or solvent mixture which is able to dissolve the pectin.
- An especially preferred solvent is water.
- the slurry has preferably a solid content of 10 to 70 % by weight, preferably of 25 to 50 % by weight, each based on the total weight of the slurry. The slurry is then spray-dried in a manner known per se.
- Another aspect of the present invention is a process for the manufacture of a composition as mentioned above, which comprises preparing a slurry, preferably an aqueous slurry, of all solid components, preferably having a solid content of 10 to 70 % by weight, preferably 25 to 50 % by weight, each based on the total weight of the slurry, and spray-drying the slurry in a manner known per se.
- Fluidized-bed granulation is an especially preferred process for the manufacture of a composition according to the present invention. It is preferred to use a known fluidized- bed granulating apparatus which comprises a fluidized-bed drying device fitted with spray means. Preferably resveratrol forms the fluidized bed, the fluidized bed being fluidized by air or an inert gas, e.g. nitrogen.
- the pectin is dissolved in an appropriate amount of water or solvent (mixture) capable of dissolving the pectin, preferably in an appropriate amount of water, and sprayed in the form of an atomized mist onto the fluidized particles in such a manner that the granulating and drying operations is accomplished in a single step.
- the pectin can be mixed with resveratrol and the fluidized bed being fluidized by air or an inert gas, e.g. nitrogen.
- the granules may be sieved to fractionate the granules as to size. While the particle size is not narrowly critical to the invention it is, for practical purposes, preferably within 50 and 1500 ⁇ m, more preferably between 100 and 1000 ⁇ m, most preferably from 150 to 850 ⁇ m.
- the resveratrol crystals are milled before the fluidizing step.
- the milling step is preferably carried out in a commercially available high shear vessel.
- the desired mean particle size of the resveratrol crystals after the milling step is in the range of 100 to 400 ⁇ m with regard to the length of the needles and may be achieved by adjusting the impeller running speed and impeller running time with respect to each other.
- the preferred milling parameters may differ depending on the high shear vessel used in the milling step, but can easily be adjusted by the person skilled in the art through no inventive fault of his own.
- one or more flow-conditioning agents are added to the resveratrol crystals before the fluidizing step.
- Preferred flow-conditioning agents are for example (hydrophilic) fumed silica, such as those commercially available under the trade name AEROSIL® from Degussa.
- a further aspect of the present invention is a process for the manufacture of a composition as mentioned above, which comprises forming a fluidized bed of resveratrol with or without pectin within a fluidized-bed drying device fitted with spray means, said fluidized bed being fluidized by air or an inert gas, and spraying a solution, preferably an aqueous solution, of pectin or only water or the solvent (mixture) in the form of an atomized mist onto the fluidized particles until the desired granule or powder is obtained.
- composition thus obtained may be further processed depending on the intended use of resveratrol and/or the desired applications.
- the composition may be compressed into tablets with conventional tabletting methods and machinery.
- compositions may further be mixed with a lubricant or a mixture of lubricants and then compressed into tablets.
- additional lubricant is preferably selected from the group of stearic acid or the magnesium or calcium salt thereof, or glyceryl behenate 45 (Compritol 888 ATO), preferably in an amount of 0.5 to 4% by weight, based on the total weight of the composition.
- the composition may be mixed with excipients.
- excipients are (microcrystalline or powdered) cellulose, (pregelatinized) starch, lactose (anhydrous or monohydrate), sorbitol, mannitol, calcium carbonate, dibasic calcium phosphate (dehydrate), tribasic calcium phosphate, calcium sulphate, dextrates, dextrin, dextrose, fructose, kaolin, lactitol and (dextrinized) sucrose.
- Dextrinized sucrose is e.g. commercially available under the trade name Di Pac® sugar from Tate and LyIe North American Sugars, Inc., Canada, or from Domino Specialty Ingredients, Baltimore, MD, USA.
- composition of the present invention may also be mixed with adjuvants.
- the present invention is directed to dosage forms based on a composition according to the present invention comprising resveratrol and pectin, such as tablets, pills, granules, dragees, capsules, and effervescent formulations such as powders and tablets.
- a composition according to the present invention comprising resveratrol and pectin, such as tablets, pills, granules, dragees, capsules, and effervescent formulations such as powders and tablets.
- the dosage form is a tablet.
- Further object of the present invention are dietary as well as pharmaceutical and personal care compositions comprising resveratrol and pectin.
- dietary compositions comprises any type of (fortified) food/feed and beverages including also clinical nutrition, and also dietary supplements.
- Beverages wherein the composition of the present invention can be used as an ingredient can be carbonated beverages e.g., flavoured seltzer waters, soft drinks or mineral drinks, as well as non-carbonated beverages e.g. flavoured waters, fruit juices, fruit punches and concentrated forms of these beverages. They may be based on natural fruit or vegetable juices or on artificial flavours. Also included are alcoholic beverages and instant beverage powders. Besides, sugar containing beverages diet beverages with non-caloric and artificial sweeteners are also included.
- dairy products obtained from natural sources or synthetic, are within the scope of the food products wherein the composition of the present invention can be used as an ingredient.
- Typical examples of such products are milk drinks, ice cream, cheese, yoghurt and the like. Milk replacing products such as soymilk drinks and tofu products are also comprised within this range of application.
- sweets which contain the composition of the present invention as an ingredient, such as confectionery products, candies, gums, desserts, e.g. ice cream, jellies, puddings, instant pudding powders and the like.
- cereals also included are cereals, snacks, cookies, pasta, soups and sauces, mayonnaise, salad dressings and the like which contain the composition of the present invention as an ingredient. Furthermore, fruit preparations used for dairy and cereals are also included.
- compositions such as tablets such as chewable tablets, effervescent tablets or film-coated tablets or capsules such as hard shell capsules wherein the compositions are used as an ingredient are also within the scope of the present invention.
- the product forms are typically added as powders to the tabletting mixture or filled into the capsules in a manner per se known for the production of capsules.
- Animal feed products such as premixes of nutritional ingredients, compound feeds, milk substitutes, liquid diets or feed preparations wherein the compositions are used as an ingredient are also within the scope of the present invention.
- compositions according to the present invention are cosmetics, toiletries and derma products. Therefore, skin and hair care products such as creams, lotions, baths, lipsticks, shampoos, conditioners, sprays or gels wherein the compositions are used as an ingredient are also within the scope of the present invention.
- the invention is concerned with the use of pectin for improving the flowability of a powder of resveratrol.
- the present invention is also directed to the use of pectin as granulating agent for compositions containing resveratrol.
- Figure 1 shows the typical needle form of resveratrol crystals.
- 30Og of the milled resveratrol are placed in the DMR fluid bed vessel and fluidized with 30m 3 /h air at 60 0 C.
- a 2.5% pectin solution in water is sprayed at a rate in a range for 2.5 to 5g/min onto the fluidized powder. 38Og of the solution is sprayed.
- the product is then dried until the product temperature reaches 40 0 C.
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Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2010530301A JP5453693B2 (en) | 2007-10-29 | 2008-10-10 | Composition containing resveratrol and pectin |
EP08844209A EP2214655A1 (en) | 2007-10-29 | 2008-10-10 | Compositions containing resveratrol and pectin |
CN200880114091A CN101842091A (en) | 2007-10-29 | 2008-10-10 | Compositions containing resveratrol and pectin |
US12/740,154 US8535724B2 (en) | 2007-10-29 | 2008-10-10 | Compositions containing resveratrol and pectin |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07021099.2 | 2007-10-29 | ||
EP07021099 | 2007-10-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2009056212A1 true WO2009056212A1 (en) | 2009-05-07 |
Family
ID=40427322
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2008/008561 WO2009056212A1 (en) | 2007-10-29 | 2008-10-10 | Compositions containing resveratrol and pectin |
Country Status (6)
Country | Link |
---|---|
US (1) | US8535724B2 (en) |
EP (1) | EP2214655A1 (en) |
JP (1) | JP5453693B2 (en) |
KR (1) | KR20100075960A (en) |
CN (1) | CN101842091A (en) |
WO (1) | WO2009056212A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8535724B2 (en) | 2007-10-29 | 2013-09-17 | Dsm Ip Assets B.V. | Compositions containing resveratrol and pectin |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112015015272A2 (en) * | 2013-04-18 | 2017-07-11 | Hershey Co | edible containing finely ground demulcent |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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WO1999048386A1 (en) * | 1998-03-24 | 1999-09-30 | Stueckler Franz | Natural substance based agent |
WO2003011339A1 (en) * | 2001-07-30 | 2003-02-13 | Dsm Ip Assets B.V. | Composition for epigallocatechin gallate |
WO2006087164A1 (en) * | 2005-02-15 | 2006-08-24 | Dsm Ip Assets B.V. | Compositions containing polysaccharides |
WO2007096078A1 (en) * | 2006-02-24 | 2007-08-30 | Dsm Ip Assets B.V. | Use of resveratrol and derivatives thereof for promoting the wellness state in mammals |
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US4826793A (en) * | 1987-08-12 | 1989-05-02 | Intercat, Inc. | Method of incorporating small crystalline catalytic ingredients into an attrition-resistant matrix |
US5707959A (en) * | 1995-05-31 | 1998-01-13 | The Procter & Gamble Company | Processes for making a granular detergent composition containing a crystalline builder |
US6270780B1 (en) * | 1997-07-25 | 2001-08-07 | Chesebrough-Pond's Usa Co., Division Of Conopco | Cosmetic compositions containing resveratrol |
JP2001002568A (en) * | 1999-06-21 | 2001-01-09 | Sunstar Inc | Food or medicine purposing prevention or treatment of unidentified clinical syndrome in menopause and maturation period |
US20060013850A1 (en) * | 1999-12-03 | 2006-01-19 | Domb Abraham J | Electropolymerizable monomers and polymeric coatings on implantable devices prepared therefrom |
DK1110550T4 (en) * | 1999-12-22 | 2007-07-02 | Dsm Ip Assets Bv | Composition comprising ascorbic acid as major constituent and pectin |
US6362308B1 (en) * | 2000-08-10 | 2002-03-26 | Alkermes Controlled Therapeutics Inc. Ii | Acid end group poly(d,l-lactide-co-glycolide) copolymers high glycolide content |
ATE307579T1 (en) * | 2001-09-03 | 2005-11-15 | Dsm Ip Assets Bv | COMPOSITIONS CONTAINING PECTIN AND ASCORBIC ACID |
AU2003210477A1 (en) * | 2002-01-09 | 2003-07-30 | Enzrel, Inc. | Liposome drug delivery of polycyclic, aromatic, antioxidant or anti-inflammatory compounds |
US20060013870A1 (en) * | 2002-05-06 | 2006-01-19 | Kuhrts Eric H | Pharmaceutical compositions of hops resins |
US6953786B2 (en) * | 2002-10-01 | 2005-10-11 | The Regents Of The University Of California | Compositions comprising plant-derived polyphenolic compounds and inhibitors of reactive oxygen species and methods of using thereof |
US7691296B2 (en) * | 2002-11-25 | 2010-04-06 | Amorepacific Corporation | Method for stabilizing active components using polyol/polymer microcapsule, and cosmetic composition containing the microcapsule |
US20050026849A1 (en) * | 2003-03-28 | 2005-02-03 | Singh Chandra U. | Water soluble formulations of digitalis glycosides for treating cell-proliferative and other diseases |
US20050013854A1 (en) * | 2003-04-09 | 2005-01-20 | Mannino Raphael J. | Novel encochleation methods, cochleates and methods of use |
AU2003903284A0 (en) * | 2003-06-26 | 2003-07-10 | Pure Bliss Foods Pty Ltd | Health confectionery |
WO2005025535A2 (en) * | 2003-09-15 | 2005-03-24 | Vectura Limited | Methods for preparing pharmaceutical compositions |
JP4471631B2 (en) * | 2003-11-14 | 2010-06-02 | アサマ化成株式会社 | Color tone retention method for food and drink using resveratrol derived from grapes and color tone retention agent for food and drink |
JP2008501024A (en) * | 2004-05-28 | 2008-01-17 | トランスフオーム・フアーマシユーチカルズ・インコーポレーテツド | Mixed co-crystal and pharmaceutical composition comprising the same |
ITPD20050224A1 (en) * | 2005-07-19 | 2007-01-20 | Actimex Srl | COMPOSITIONS CONTAINING MICRONUTRIENTS IN PARTICULAR ANTIOXIDANT ACTIVITY AND THEIR USE |
EP1928268A1 (en) * | 2005-09-30 | 2008-06-11 | DSMIP Assets B.V. | Novel compositions containing polyphenols |
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ATE510538T1 (en) * | 2006-08-11 | 2011-06-15 | Univ Johns Hopkins | COMPOSITIONS AND METHODS FOR NERVE PROTECTION |
US8535724B2 (en) | 2007-10-29 | 2013-09-17 | Dsm Ip Assets B.V. | Compositions containing resveratrol and pectin |
-
2008
- 2008-10-10 US US12/740,154 patent/US8535724B2/en active Active
- 2008-10-10 CN CN200880114091A patent/CN101842091A/en active Pending
- 2008-10-10 KR KR1020107009054A patent/KR20100075960A/en not_active Application Discontinuation
- 2008-10-10 EP EP08844209A patent/EP2214655A1/en not_active Withdrawn
- 2008-10-10 JP JP2010530301A patent/JP5453693B2/en active Active
- 2008-10-10 WO PCT/EP2008/008561 patent/WO2009056212A1/en active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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WO1999048386A1 (en) * | 1998-03-24 | 1999-09-30 | Stueckler Franz | Natural substance based agent |
WO2003011339A1 (en) * | 2001-07-30 | 2003-02-13 | Dsm Ip Assets B.V. | Composition for epigallocatechin gallate |
WO2006087164A1 (en) * | 2005-02-15 | 2006-08-24 | Dsm Ip Assets B.V. | Compositions containing polysaccharides |
WO2007096078A1 (en) * | 2006-02-24 | 2007-08-30 | Dsm Ip Assets B.V. | Use of resveratrol and derivatives thereof for promoting the wellness state in mammals |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8535724B2 (en) | 2007-10-29 | 2013-09-17 | Dsm Ip Assets B.V. | Compositions containing resveratrol and pectin |
Also Published As
Publication number | Publication date |
---|---|
US8535724B2 (en) | 2013-09-17 |
JP2011500737A (en) | 2011-01-06 |
US20110039945A1 (en) | 2011-02-17 |
EP2214655A1 (en) | 2010-08-11 |
CN101842091A (en) | 2010-09-22 |
JP5453693B2 (en) | 2014-03-26 |
KR20100075960A (en) | 2010-07-05 |
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