WO2009052607A1 - Procédé et appareil d'imagerie d'une oxygénation microvasculaire - Google Patents

Procédé et appareil d'imagerie d'une oxygénation microvasculaire Download PDF

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Publication number
WO2009052607A1
WO2009052607A1 PCT/CA2008/001837 CA2008001837W WO2009052607A1 WO 2009052607 A1 WO2009052607 A1 WO 2009052607A1 CA 2008001837 W CA2008001837 W CA 2008001837W WO 2009052607 A1 WO2009052607 A1 WO 2009052607A1
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WO
WIPO (PCT)
Prior art keywords
tissue
image
images
oxygenated
parameter
Prior art date
Application number
PCT/CA2008/001837
Other languages
English (en)
Inventor
Yasser Sherif Fawzy
Original Assignee
Perceptronix Medical Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Perceptronix Medical Inc. filed Critical Perceptronix Medical Inc.
Publication of WO2009052607A1 publication Critical patent/WO2009052607A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/042—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances characterised by a proximal camera, e.g. a CCD camera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14542—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring blood gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter

Definitions

  • the present invention relates to an apparatus and a method for quantifying tissue microvascular properties, namely tissue blood volume fraction and blood oxygenation directly from the image data.
  • the quantified information is then used for enhancing image contrast and thereby increasing the visual sensitivity to cancer lesions.
  • the present invention also relates to a method and apparatus used for quantifying the tissue/mucosa oxygenation levels directly from the image data to detect and monitor early changes in the mucosa oxygen supply and perfusion for applications like ischemia and micro-vascular surgery.
  • Clinicians may detect various diseases such as cancer by observing features in white light reflectance images such as the tissue color and surface morphology. While changes in the physical appearance (color and morphology) of tissue using white light is useful, to accomplish more reliable and earlier detection of diseases, such as cancer, a number of research groups have investigated the use of tissue autofluorescence to improve the detection sensitivity of cancerous lesions. Just as certain morphological changes in tissue may be associated with disease, chemical changes may also be exploited for disease detection especially for early detection of disease. When tissue is illuminated (or excited) with specific wavelengths of ultraviolet (UV) or visible light, biological molecules (fluorophores) will absorb the energy and emit it as fluorescent light at longer wavelengths (green/red wavelength region).
  • UV ultraviolet
  • fluorophores biological molecules
  • Another imaging method utilizes near infrared light to measure tissue oxygenation in healthy and diseased tissue. It is known that cancerous tissues exhibit hypoxia caused by increased oxygen consumption due to rapid growth of cancerous cells. However, other unrelated chromophores tend to overwhelm and obscure the effects of hypoxia at visible imaging wavelengths interfering with the ability of conventional imaging systems to detect tissue oxygenation status.
  • Biological tissue is a turbid medium which absorbs and scatters incident light. When light impinges on tissue, it is typically multiple elasticaliy scattered but at the same time absorption and fluorescence can occur, too. Further scattering and absorption can occur before light exits the tissue surface containing compositional and structural information of the tissue.
  • tissue scattering property varies with a tissue's microstructure properties and morphology, which are often accompanied with tissue pathological changes.
  • tissue pathological changes For example, when normal tissue becomes cancerous, the nuclear size of the cells and the epithelial layer thickness increase as does the total volume occupied by the cells (micro-scatterers).
  • tissue microstructure and morphology have been found to cause intrinsic differences in the light-scattering properties of the normal and cancerous lesions. Recent studies have shown that vascularization related changes and morphological related changes are very important features for early cancer detection.
  • the present invention is based on quantifying both the de-oxygenated and the oxygenated parts of the mucosa blood which would provide additional functional/diagnostic information that has minimal effect on image coloration but could improve the detection and localization of cancerous related changes and/or other related pathologies.
  • Different pathologies including the lung cancer modify the amount of deoxygenated blood within the tissue.
  • the effect of such changes on the image redness color is weak and can not be obtained from simple color quantification.
  • the present invention discloses image contrast enhancement method and apparatus based on actual tissue properties quantification (morphological and vascular) directly from the image data.
  • the use of quantified de-oxygenated blood provides improved diagnostic accuracy for cancer detection with superior classification when compared to the prior art.
  • present invention describes a method and an apparatus for accurate imaging of tissue/mucosa oxygenation to improve diagnostic accuracy of current imaging systems to even slight changes in the mucosa/tissue oxygen supply and perfusion.
  • FIG. 7 is an illustration of an deoxygenated threshold imaging approach
  • FIG. 2 describes another embodiment of the present invention in which the subject is illuminated simultaneously with a broad band visible illumination light from light source unit 21 , through light guide 22 in endoscope 24.
  • Returned radiation is captured by a detecting device 28 employing a plurality of CCDs (30, 31 , 32), preferably three for detecting band images such as blue, green and/or red/NIR images with a specific spectral properties defined by properties of the band pass filters disposed in front of each of the CCDs.
  • the detecting device according to this embodiment is preferably mounted on the proximal end of the endoscope but could also be disposed at the distal tip of the endoscope. Reflected light carried by an image guide disposed within the endoscope is directed to the detecting device 28.
  • Tissue oxygenation status and micro-vasculature parameters play central role in detection and monitoring of ischemia and tissue viability as well as tumor physiology and cancer treatment. Routine evaluation of the pre-therapeutic tissue oxygenation status is of prime importance in establishing individual therapeutic strategies including combined radiotherapy, chemotherapy and photodynamic therapy. Another area where measurement of tissue oxygenation status can serve as an important endpoint is the assessment of the efficacy of the newly developed hypoxia- or angiogenesis-targeted therapies.
  • in-vivo measurement of tumor oxygenation is a challenging procedure especially for difficult to access (endoscopic) lesions such as the lung.
  • the present invention provides direct and real-time measurement of tumor hypoxia-related parameters in non-invasive manner, during routine endoscopy procedure.
  • Ischemia detection is related to the detection of the area of tissues that is hypoxic or has deficiency in oxygen supply.
  • the method of the present invention is used to detect the presence of ischemia by calculating the tissue oxygenation index (TOI) through different areas within the image.
  • TOI tissue oxygenation index
  • the normal tissue has TOI value between 65%-75% and the TOI value of the hypoxic is usually 55% or less.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Optics & Photonics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pathology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Endoscopes (AREA)

Abstract

La présente invention porte sur un appareil et sur un procédé de quantification de l'indice de sang désoxygéné tissulaire (dHbi) directement à partir de données d'image pour améliorer le contraste d'image et la détection de lésions suspectes/ cancéreuses et/ou d'autres types de pathologies. L'indice de sang désoxygéné tissulaire (dHBi) est défini à l'aide d'une analyse de modèle d'approximation de dispersion en tant que volume de sang désoxygéné multiplié par une amplitude de dispersion (kHbi). La présente invention porte également sur un nouveau procédé et un nouveau dispositif de mesure en temps réel de l'indice d'oxygénation tissulaire (TOI).
PCT/CA2008/001837 2007-10-24 2008-10-17 Procédé et appareil d'imagerie d'une oxygénation microvasculaire WO2009052607A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98225207P 2007-10-24 2007-10-24
US60/982,252 2007-10-24

Publications (1)

Publication Number Publication Date
WO2009052607A1 true WO2009052607A1 (fr) 2009-04-30

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2008/001837 WO2009052607A1 (fr) 2007-10-24 2008-10-17 Procédé et appareil d'imagerie d'une oxygénation microvasculaire

Country Status (1)

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WO (1) WO2009052607A1 (fr)

Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9654745B2 (en) 2010-03-17 2017-05-16 Haishan Zeng Rapid multi-spectral imaging methods and apparatus and applications for cancer detection and localization
WO2017216585A1 (fr) * 2016-06-17 2017-12-21 Ucl Business Plc Procédé et appareil d'estimation de la valeur d'un paramètre physique dans un tissu biologique
JP2018515159A (ja) * 2015-03-26 2018-06-14 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． 人間又は動物の体内の関心構造を照射する装置、システム、及び方法
DE102017215160A1 (de) * 2017-08-30 2019-02-28 Carl Zeiss Meditec Ag Verfahren zur räumlich überlagerten Darstellung einer hämodynamischen Größe eines Objekts und eines Bildes des Objekts
US11076997B2 (en) 2017-07-25 2021-08-03 Smith & Nephew Plc Restriction of sensor-monitored region for sensor-enabled wound dressings
US11324424B2 (en) 2017-03-09 2022-05-10 Smith & Nephew Plc Apparatus and method for imaging blood in a target region of tissue
US11395872B2 (en) 2008-01-08 2022-07-26 Smith & Nephew, Inc. Sustained variable negative pressure wound treatment and method of controlling same
US11559438B2 (en) 2017-11-15 2023-01-24 Smith & Nephew Plc Integrated sensor enabled wound monitoring and/or therapy dressings and systems
US11596553B2 (en) 2017-09-27 2023-03-07 Smith & Nephew Plc Ph sensing for sensor enabled negative pressure wound monitoring and therapy apparatuses
US11633147B2 (en) 2017-09-10 2023-04-25 Smith & Nephew Plc Sensor enabled wound therapy dressings and systems implementing cybersecurity
US11633153B2 (en) 2017-06-23 2023-04-25 Smith & Nephew Plc Positioning of sensors for sensor enabled wound monitoring or therapy
US11638664B2 (en) 2017-07-25 2023-05-02 Smith & Nephew Plc Biocompatible encapsulation and component stress relief for sensor enabled negative pressure wound therapy dressings
US11690570B2 (en) 2017-03-09 2023-07-04 Smith & Nephew Plc Wound dressing, patch member and method of sensing one or more wound parameters
US11717447B2 (en) 2016-05-13 2023-08-08 Smith & Nephew Plc Sensor enabled wound monitoring and therapy apparatus
US11744741B2 (en) 2008-03-12 2023-09-05 Smith & Nephew, Inc. Negative pressure dressing and method of using same
US11759144B2 (en) 2017-09-10 2023-09-19 Smith & Nephew Plc Systems and methods for inspection of encapsulation and components in sensor equipped wound dressings
US11791030B2 (en) 2017-05-15 2023-10-17 Smith & Nephew Plc Wound analysis device and method
US11839464B2 (en) 2017-09-28 2023-12-12 Smith & Nephew, Plc Neurostimulation and monitoring using sensor enabled wound monitoring and therapy apparatus
US11883262B2 (en) 2017-04-11 2024-01-30 Smith & Nephew Plc Component positioning and stress relief for sensor enabled wound dressings
US11925735B2 (en) 2017-08-10 2024-03-12 Smith & Nephew Plc Positioning of sensors for sensor enabled wound monitoring or therapy
US11931165B2 (en) 2017-09-10 2024-03-19 Smith & Nephew Plc Electrostatic discharge protection for sensors in wound therapy
US11944418B2 (en) 2018-09-12 2024-04-02 Smith & Nephew Plc Device, apparatus and method of determining skin perfusion pressure
US11957545B2 (en) 2017-09-26 2024-04-16 Smith & Nephew Plc Sensor positioning and optical sensing for sensor enabled wound therapy dressings and systems
US11969538B2 (en) 2018-12-21 2024-04-30 T.J.Smith And Nephew, Limited Wound therapy systems and methods with multiple power sources
US12011942B2 (en) 2019-03-18 2024-06-18 Smith & Nephew Plc Rules for sensor integrated substrates

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CA2595213A1 (fr) * 2005-01-21 2006-07-27 Perceptronix Medical Inc. Procede et appareil pour mesurer une evolution cancereuse a partir de mesures de reflectance spectrale obtenues par imagerie endoscopique
US20070055119A1 (en) * 2005-09-08 2007-03-08 Lash Robert E Optical probe for optical imaging system
US20070219439A1 (en) * 2004-03-31 2007-09-20 Imedos Gmbh Spectral Photometry Method for Determining the Oxygen Saturatiobn of the Blood in Optically Accessible Blood Vessels
US20080177163A1 (en) * 2007-01-19 2008-07-24 O2 Medtech, Inc. Volumetric image formation from optical scans of biological tissue with multiple applications including deep brain oxygenation level monitoring

Patent Citations (4)

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US20070219439A1 (en) * 2004-03-31 2007-09-20 Imedos Gmbh Spectral Photometry Method for Determining the Oxygen Saturatiobn of the Blood in Optically Accessible Blood Vessels
CA2595213A1 (fr) * 2005-01-21 2006-07-27 Perceptronix Medical Inc. Procede et appareil pour mesurer une evolution cancereuse a partir de mesures de reflectance spectrale obtenues par imagerie endoscopique
US20070055119A1 (en) * 2005-09-08 2007-03-08 Lash Robert E Optical probe for optical imaging system
US20080177163A1 (en) * 2007-01-19 2008-07-24 O2 Medtech, Inc. Volumetric image formation from optical scans of biological tissue with multiple applications including deep brain oxygenation level monitoring

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11395872B2 (en) 2008-01-08 2022-07-26 Smith & Nephew, Inc. Sustained variable negative pressure wound treatment and method of controlling same
US11744741B2 (en) 2008-03-12 2023-09-05 Smith & Nephew, Inc. Negative pressure dressing and method of using same
US9654745B2 (en) 2010-03-17 2017-05-16 Haishan Zeng Rapid multi-spectral imaging methods and apparatus and applications for cancer detection and localization
JP2018515159A (ja) * 2015-03-26 2018-06-14 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． 人間又は動物の体内の関心構造を照射する装置、システム、及び方法
US11717447B2 (en) 2016-05-13 2023-08-08 Smith & Nephew Plc Sensor enabled wound monitoring and therapy apparatus
WO2017216585A1 (fr) * 2016-06-17 2017-12-21 Ucl Business Plc Procédé et appareil d'estimation de la valeur d'un paramètre physique dans un tissu biologique
US11141044B2 (en) 2016-06-17 2021-10-12 Ucl Business Ltd Method and apparatus for estimating the value of a physical parameter in a biological tissue
US11324424B2 (en) 2017-03-09 2022-05-10 Smith & Nephew Plc Apparatus and method for imaging blood in a target region of tissue
US11690570B2 (en) 2017-03-09 2023-07-04 Smith & Nephew Plc Wound dressing, patch member and method of sensing one or more wound parameters
US11883262B2 (en) 2017-04-11 2024-01-30 Smith & Nephew Plc Component positioning and stress relief for sensor enabled wound dressings
US11791030B2 (en) 2017-05-15 2023-10-17 Smith & Nephew Plc Wound analysis device and method
US11633153B2 (en) 2017-06-23 2023-04-25 Smith & Nephew Plc Positioning of sensors for sensor enabled wound monitoring or therapy
US11638664B2 (en) 2017-07-25 2023-05-02 Smith & Nephew Plc Biocompatible encapsulation and component stress relief for sensor enabled negative pressure wound therapy dressings
US11076997B2 (en) 2017-07-25 2021-08-03 Smith & Nephew Plc Restriction of sensor-monitored region for sensor-enabled wound dressings
US11925735B2 (en) 2017-08-10 2024-03-12 Smith & Nephew Plc Positioning of sensors for sensor enabled wound monitoring or therapy
DE102017215160A1 (de) * 2017-08-30 2019-02-28 Carl Zeiss Meditec Ag Verfahren zur räumlich überlagerten Darstellung einer hämodynamischen Größe eines Objekts und eines Bildes des Objekts
US11759144B2 (en) 2017-09-10 2023-09-19 Smith & Nephew Plc Systems and methods for inspection of encapsulation and components in sensor equipped wound dressings
US11633147B2 (en) 2017-09-10 2023-04-25 Smith & Nephew Plc Sensor enabled wound therapy dressings and systems implementing cybersecurity
US11931165B2 (en) 2017-09-10 2024-03-19 Smith & Nephew Plc Electrostatic discharge protection for sensors in wound therapy
US11957545B2 (en) 2017-09-26 2024-04-16 Smith & Nephew Plc Sensor positioning and optical sensing for sensor enabled wound therapy dressings and systems
US11596553B2 (en) 2017-09-27 2023-03-07 Smith & Nephew Plc Ph sensing for sensor enabled negative pressure wound monitoring and therapy apparatuses
US11839464B2 (en) 2017-09-28 2023-12-12 Smith & Nephew, Plc Neurostimulation and monitoring using sensor enabled wound monitoring and therapy apparatus
US11559438B2 (en) 2017-11-15 2023-01-24 Smith & Nephew Plc Integrated sensor enabled wound monitoring and/or therapy dressings and systems
US11944418B2 (en) 2018-09-12 2024-04-02 Smith & Nephew Plc Device, apparatus and method of determining skin perfusion pressure
US11969538B2 (en) 2018-12-21 2024-04-30 T.J.Smith And Nephew, Limited Wound therapy systems and methods with multiple power sources
US12011942B2 (en) 2019-03-18 2024-06-18 Smith & Nephew Plc Rules for sensor integrated substrates
US12016994B2 (en) 2019-10-07 2024-06-25 Smith & Nephew Plc Sensor enabled negative pressure wound monitoring apparatus with different impedances inks

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