WO2009048081A1 - Method, apparatus and program for diagnosis of fatty liver disease, and method for screening of therapeutic agent for fatty liver disease - Google Patents
Method, apparatus and program for diagnosis of fatty liver disease, and method for screening of therapeutic agent for fatty liver disease Download PDFInfo
- Publication number
- WO2009048081A1 WO2009048081A1 PCT/JP2008/068308 JP2008068308W WO2009048081A1 WO 2009048081 A1 WO2009048081 A1 WO 2009048081A1 JP 2008068308 W JP2008068308 W JP 2008068308W WO 2009048081 A1 WO2009048081 A1 WO 2009048081A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- fatty liver
- liver disease
- disease
- diagnosis
- screening
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/08—Hepato-biliairy disorders other than hepatitis
- G01N2800/085—Liver diseases, e.g. portal hypertension, fibrosis, cirrhosis, bilirubin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/56—Staging of a disease; Further complications associated with the disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Endocrinology (AREA)
- Food Science & Technology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The object is to diagnose the presence or absence of the occurrence of a fatty liver disease, the degree of progression of a fatty liver disease or the like in a simpler manner compared with conventional liver biopsies. Disclosed is a method for diagnosing a fatty liver disease, which comprises the steps of: analyzing at least one component selected from the group consisting of a chylomicron, a very-low-density lipoprotein, a chylomicron remnant and a very-low-density lipoprotein remnant contained in a sample derived from the blood collected from a subject; and determining the presence or absence of the occurrence of the fatty liver disease, the severity of the disease, or the therapeutic effect against the disease in the subject based on the results of the analysis.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009537013A JPWO2009048081A1 (en) | 2007-10-12 | 2008-10-08 | Method for diagnosing fatty liver disease, diagnostic device, diagnostic program, and screening method for therapeutic agent for fatty liver disease |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007266431 | 2007-10-12 | ||
JP2007-266431 | 2007-10-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2009048081A1 true WO2009048081A1 (en) | 2009-04-16 |
Family
ID=40549225
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/068308 WO2009048081A1 (en) | 2007-10-12 | 2008-10-08 | Method, apparatus and program for diagnosis of fatty liver disease, and method for screening of therapeutic agent for fatty liver disease |
Country Status (2)
Country | Link |
---|---|
JP (1) | JPWO2009048081A1 (en) |
WO (1) | WO2009048081A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2013164755A (en) * | 2012-02-10 | 2013-08-22 | Crust Inc | Diagnosis support system, diagnosis support program and diagnosis support method |
CN111971710A (en) * | 2018-03-26 | 2020-11-20 | 皇家飞利浦有限公司 | Generating spectral inflammation maps from spectral imaging data |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0915225A (en) * | 1995-04-28 | 1997-01-17 | Tosoh Corp | Method for analyzing serum lipoprotein |
JP2002139501A (en) * | 2000-10-30 | 2002-05-17 | Mass Medical Kk | Method for analyzing and diagnosing lipoprotein subclass |
JP2004264051A (en) * | 2003-02-07 | 2004-09-24 | Shinichi Usui | Analytical method and analytical program for lipoprotein |
JP2006349457A (en) * | 2005-06-15 | 2006-12-28 | Tokyo Medical & Dental Univ | Screening method of curative medicine of non-alcoholic fatty liver |
JP2007192746A (en) * | 2006-01-20 | 2007-08-02 | Keio Gijuku | Determination method of oxydation stress |
-
2008
- 2008-10-08 JP JP2009537013A patent/JPWO2009048081A1/en active Pending
- 2008-10-08 WO PCT/JP2008/068308 patent/WO2009048081A1/en active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0915225A (en) * | 1995-04-28 | 1997-01-17 | Tosoh Corp | Method for analyzing serum lipoprotein |
JP2002139501A (en) * | 2000-10-30 | 2002-05-17 | Mass Medical Kk | Method for analyzing and diagnosing lipoprotein subclass |
JP2004264051A (en) * | 2003-02-07 | 2004-09-24 | Shinichi Usui | Analytical method and analytical program for lipoprotein |
JP2006349457A (en) * | 2005-06-15 | 2006-12-28 | Tokyo Medical & Dental Univ | Screening method of curative medicine of non-alcoholic fatty liver |
JP2007192746A (en) * | 2006-01-20 | 2007-08-02 | Keio Gijuku | Determination method of oxydation stress |
Non-Patent Citations (2)
Title |
---|
MAURIZIO CASSADER ET AL.: "Postprandial Triglyceride-Rich Lipoprotein Metabolism and Insulin Sensitivity in Nonalcoholic Steatohepatitis Patients", LIPIDS, vol. 36, no. 10, 2001, pages 1117 - 1124 * |
MITSUYO OKAZAKI: "Atarashii Kessei Lipo Tanpakushitsu no Bunseki Hoho: Gel Roka HPLC", JOURNAL OF ELECTROPHORESIS, vol. 49, no. 4, 15 December 2005 (2005-12-15), pages 111 - 118 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2013164755A (en) * | 2012-02-10 | 2013-08-22 | Crust Inc | Diagnosis support system, diagnosis support program and diagnosis support method |
CN111971710A (en) * | 2018-03-26 | 2020-11-20 | 皇家飞利浦有限公司 | Generating spectral inflammation maps from spectral imaging data |
Also Published As
Publication number | Publication date |
---|---|
JPWO2009048081A1 (en) | 2011-02-24 |
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