WO2009047598A2 - Dispositif de régénération de tissu basé sur le collagène et procédé pour la production de ce dispositif - Google Patents

Dispositif de régénération de tissu basé sur le collagène et procédé pour la production de ce dispositif Download PDF

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Publication number
WO2009047598A2
WO2009047598A2 PCT/IB2008/001922 IB2008001922W WO2009047598A2 WO 2009047598 A2 WO2009047598 A2 WO 2009047598A2 IB 2008001922 W IB2008001922 W IB 2008001922W WO 2009047598 A2 WO2009047598 A2 WO 2009047598A2
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WO
WIPO (PCT)
Prior art keywords
collagen
layers
titanium
tissue regeneration
titanium mesh
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Application number
PCT/IB2008/001922
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English (en)
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WO2009047598A3 (fr
WO2009047598A9 (fr
Inventor
Fernando Briceno Rincon
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Fernando Briceno Rincon
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Application filed by Fernando Briceno Rincon filed Critical Fernando Briceno Rincon
Publication of WO2009047598A2 publication Critical patent/WO2009047598A2/fr
Publication of WO2009047598A3 publication Critical patent/WO2009047598A3/fr
Publication of WO2009047598A9 publication Critical patent/WO2009047598A9/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/446—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46

Definitions

  • the present invention is related with an innovative tissue regenerator system, with a wide range of clinical applications: this device is essentially made with an intestinal submucose reinforced with a titanium mesh, in such way that it integrates in one structure different variations of thickness and configurations of the components; making it a versatile and simple to use promoter of faster, organized and more effective healing processes.
  • this device is essentially made with an intestinal submucose reinforced with a titanium mesh, in such way that it integrates in one structure different variations of thickness and configurations of the components; making it a versatile and simple to use promoter of faster, organized and more effective healing processes.
  • Figure number 1 shows a transverse view of the yeyunum (Small intestine).
  • Figure number 2 shows a schematic representation of a multilayered membrane composed by multiple single layers of collagen in different orientations.
  • Figure number 3 shows the porcine intestinal submucose isolation and purification process.
  • Figure number 4 shows a conventional titanium mesh.
  • Figure number 5 shows the collagen incorporation phase of the intestinal submucose to the titanium mesh.
  • Figure number 6 shows three different titanium mesh designs, during the collagen incorporation phase.
  • Figure number 7 Shows the first embodiment of the final product of this invention in a 3D configuration.
  • Figure number 8 shows a second embodiment of the final product of this invention in a 3D configuration.
  • Figure number 9 shows a third embodiment of the final product of this invention in a 3D configuration.
  • Figure number 10 shows a fourth embodiment of the final product of this invention in a 3D configuration.
  • the present invention provides a new device that combines the biological properties of collagen originating from the small intestinal submucose of mammals and the alloplastic advantages of titanium meshes, as well as its preparation method.
  • the object of the present application is to present the development of new collagen membranes originating from the small intestinal submucose reinforced with a titanium mesh, integrating the two materials to make up the device of the present invention which can have variations in its thickness, as much in the biological component produced by the collagen membranes originating from the small intestinal submucose as in the alloplastic component made of titanium.
  • the product obtained through the procedure of the present invention can be used in general in reconstructive surgeries, for example in oral and maxillofacial surgery to perform guided bone regeneration techniques to reconstruct dento alveolar bone of the maxilla and mandibule; in plastic and reconstructive surgery, to regenerate bone defects in the face and cranium; in general surgery, as a reinforcement of the abdominal walls for the handling of eventrations and hernias of different sizes; in spinal surgery and neurosurgery, as a protective material for intervertebral discs and implants.
  • These membranes provide an option for the remodeling and reconstruction of tissue given their structure and composition.
  • the manufacturing process is simple and involves the superposition of several layers of a matrix of purified collagen that cover a flat structure of titanium of different densities and mesh designs, making it versatile in its clinical applications.
  • the titanium structure allows the compound to be molded to imitate and maintain tri-dimensional shapes acting as a container, that can be set and immobilized in a stable form.
  • Its biological component made up of the submucose acts as a barrier and as tissue regeneration material.
  • the present invention provides a regeneration of tissues system characterized because it includes collagen membranes originating from the intestinal submucose and a titanium mesh of diverse geometric configurations, in such a way as it is integrated into a titanium-collagen structure.
  • the system of regeneration of tissues of the present invention is characterized because of the collagen originating from the intestinal submucose is of a warm-blooded vertebrae.
  • the system of tissue regeneration of the present invention is characterized because the collagen originating from the intestinal submucose originates from a porcine.
  • the regeneration of materials device such as that from the present invention is characterized because it has a thickness that varies between 0.1 and 1.5 mm and it has a size that varies between 1x1 cm to 25x25 cm.
  • the tissue regeneration device like that of the present invention is characterized because it has a thickness that varies between 0.3 and 1.2 mm and it has a size that varies between 5x5 cm to 20x20 cm.
  • the tissue regeneration device like that of the present invention is characterized because it has a thickness that varies between 0.5 and 1.0 mm and it has a size that varies between 10x10 cm to 15x15 cm.
  • the tissue regeneration device like that of the present invention is characterized because the titanium mesh has orifices that vary between 1.0 and 2.3 mm.
  • the tissue regeneration device like that of the present invention is characterized because the titanium mesh has orifices of 1.0 mm.
  • the tissue regeneration device like that of the present invention is characterized because the titanium mesh has orifices of 1.5mm.
  • the tissue regeneration device like that of the present invention is characterized because the titanium mesh has orifices of 2.0 mm.
  • the tissue regeneration device like that of the present invention is characterized because the titanium mesh has orifices of 2.3 mm.
  • the tissue regeneration device like that of the present invention is characterized because the titanium mesh is flat with the capacity to be molded.
  • the tissue regeneration device like that of the present invention is characterized because the titanium mesh has diverse 3-D shapes.
  • the tissue regeneration device like that of the present invention is characterized because the titanium mesh has Y, H, rectangular, squared and half-moon shapes. In another embodiment, the tissue regeneration device like that of the present invention is characterized because it can adhere from one layer of collagen to multiple layers of collagen.
  • the tissue regeneration device like that of the present invention is characterized because it can adhere from one layer of collagen to six layers of collagen.
  • the tissue regeneration device like that of the present invention is characterized because it can adhere from two layers of collagen to four layers of collagen.
  • Another objective in the present invention is to include the preparation method for the titanium-collagen tissue regeneration device for the present invention.
  • the present invention provides a method for the preparation of the tissue regeneration system like that of the present invention characterized because it contains the stages of:
  • a isolation and purification of collagen from the small intestinal submucose; b. design of collagen structures of determined thicknesses; c. design of sterilized titanium meshes in diverse geometric shapes; d. adhesion of the isolated and purified layers of collagen within the titanium meshes until the device is achieved.
  • the method of the present invention is characterized because the adhesion of the layers of collagen is performed by superposing multiple layers of collagen on the titanium meshes and later two to six additional layers of collagen are added on the titanium mesh.
  • the method of the present invention is characterized because the superposition of the layers of collagen are performed without rotation in each additional layer. In another embodiment, the method of the present invention is characterized because the superposition of the layers of collagen are performed with a 90° rotation in each layer that is added.
  • the method of the present invention is characterized because the stage of adhesion of collagen layers on the titanium mesh are done in a sterile area with lamina flow.
  • the method of the present invention is characterized because after the superposition of the collagen layers and the titanium mesh, the resulting tissue regenerative device is left to dry for a period of 12 to 24 hours in a sterile area.
  • the method like that of the present invention is characterized because after it is dried, the resulting product is cut and packaged.
  • the method like that of the present invention is characterized because the resulting product is sterilized in ethylene oxide, gamma radiation, radiation with electrons or ultra-violet radiation.
  • this invention is related to an implant graft adequate for various medical applications and its production process.
  • the small intestinal submucose of porcines is purified through an established process and is adhered to a titanium mesh with varied designs depending on the clinical use it will be given.
  • This combination of two materials has not been described in international medical literature, nor have its clinical applications, given that for tissue regeneration, compounds do not exist with collagen and titanium that achieve the combination of the individual benefits of each material to strengthen their benefits.
  • the necessary characteristics for the clinical applications of this compound are biocompatibility; biomechanical resistance to stress and compressive forces; the ability to be set by screws, tacks, staples or sutures; regenerative activity; resistance to infection, in addition to being able to be produced in different sizes and thicknesses, with different designs for the metallic frame that permits the material to be molded according to its use and afterward stability is shown throughout the healing period.
  • the combination of the two materials also should be provided in a sterile manner for its clinical use.
  • the porcine intestinal submucose is a natural derivate obtained from the pig's small intestine. It is found between the mucose layer and the muscular layer. It's constitution is mainly type l-lll and Vl collagen with a secondary contents of carbohydrates and lipids, it is totally a cellular, biocompatible, implantable in humans and reabsorbable.
  • the submucose induces the remodeling of the objective tissue, joining in, and resulting on functional tissues.
  • this process includes a fast angiogenic response, a mononuclear cell infiltration during the post implant period, and the deposition of a new matrix to replace the SIS matrix.
  • angiogenesis or vascular neoformation is known to be needed for the supportive invading cells nutrition, same as for the elimination of discharging products from the cells. It allows the blood stream to irrigate, acting as a defense against infectious agents that could take over the support, and removes its demotion.
  • the advantages of these membranes are: it's excellent resistance for fixing and replacing the damaged tissues, ease to handle and high biocompatibility. In addition, it does not show the two big issues other grafts have.
  • the SIS does not encapsulate nor dissolve. The encapsulation suffered by grafts is due to a response of strange body reaction, resulting in non-functional tissue and a rigid scar.
  • its incorporation process produced by its components that are basically active proteins in charge of tissue regeneration result in a more effective and faster healing process.
  • Titanium is the ninth most abundant element and the fourth most abundant structural metal on the earth's crust. Large deposits of rutile and ilmenite ore are located in the United States, Canada and Australia. Titanium ore is treated with chlorine gas to produce an intermediate titanium chloride product. The titanium chloride is reduced with either magnesium or sodium metal to titanium metal granules. The resultant granules are pressed into a dense compact, and the compacts are welded together to form an electrode for vacuum melting. An electric current is passed through the electrode for vacuum melting. An electric current is passed through the electrode in a vacuum arc furnace to produce a titanium ingot. The remelted ingot is further processed by conventional metalworking techniques to produce bars, wires, sheets, plates and tubular products.
  • CP commercially Pure
  • Grades 1 , 2, 3, or 4 are available with a stable alpha phase microstructure. The primary difference is related to oxygen content.
  • the strength of unalloyed titanium increases as the oxygen content increases from grade 1 through grade 4. Small quantities of nitrogen and carbon tend to stabilize the alpha phase.
  • the composition requirements of the four unalloyed titanium grades are precisely controlled and documented in ASTM F 67 specification for surgical implant material.
  • Composition limits are also specified in the ISO 5832-2 international standard.
  • the density and modulus of elasticity Two important physical properties of titanium for implant applications are the density and modulus of elasticity.
  • the density of unalloyed titanium is 56% the density of wrought 316 L satin steel and about 53% the density of cast Co_Cr- Mo alloy.
  • the low density of titanium yield to a weight reduction of nearly 50% when implants of similar dimensions are compared.
  • the weight reduction represents a patient comfort factor especially for large sized implants.
  • Elasticity modulus or Young's modulus is a physical property of a material that describes the stress per unit strain in the elastic region. A material with high modulus of elasticity will transfer less stress form the implant to the bone.
  • the tensile properties of unalloyed titanium are dependent on grade and type or metallurgical processing.
  • ASTM F 67 specification outlines the minimum mechanical properties that must be met in the annealed or softest condition.
  • ISO 5832-2 international standard also covers annealed mechanical properties for grades 1 ,2,3, 4A, and includes Grade 4B in the cold work condition.
  • Moderately to highly stressed implants are normally fabricated from cold worked material. Titanium can be cold worked to produce high tensile properties that area nearly equivalent to cold worked 316L stainless steel. Unalloyed titanium is generally not capable of attaining extremely high tensile strength. Consequently, these small diameter implants are also available in Ti-6AL-4V alloy with a moderately high tensile strength of around 920 Mpa.
  • ASTM f 67 requirements UTS
  • minimum 0.2% yield strength UTS
  • minimum elongation rate identical for bars, wires, sheets, strips and plates.
  • Additional mechanical property requirements for unalloyed titanium sheet, strip, and plate include maximum 0.2% yield strength.
  • Maximum yield strength and bend test requirements ensure that titanium flat mill products can be fabricated into various implant shapes in both the transverse and the longitudinal planes.
  • Fatigue is defined as the process of progressive, permanent structural change occurring in a material that is subjected to altering stresses and strains.
  • the alternating stress and strain effects are usually localized and may produce cracks or complete fracture after sufficient number of cycles.
  • Unalloyed titanium fatigue life is influenced by many factors including composition, grain size, processing history, surface finish, residual surface stress and ultimate tensile strength.
  • Major test dependent variables include type of alternating load, specimen geometry frequency, and test environment.
  • titanium and some of its alloys may be the most biocompatible and corrosion resistance metallic implant materials in present use.
  • Titanium readily forms a passive surface film, which provides a high degree of immunity against attack by most mineral acids and chlorides.
  • the ability of a passive film to repassivate readily if the film is scratched, abraded or disrupted is considered and important feature of any highly corrosion resistant material.
  • unalloyed titanium with implant quality 316L stainless steel should be avoided to eliminate any possibility of galvanic corrosion or accelerated fretting corrosion.
  • Many of the advantages of unalloyed titanium such an improve corrosion resistance, improved biocompatibility, and absence of allergic reactions may not be realized with a mixed metal system.
  • Unalloyed titanium also exhibits unique biocompatibility properties, which include soft tissue and bone adhesion to the titanium surface
  • implants may be sterilized by any of the standard methods such steam autoclave, ETO, gamma radiation and RF discharge.
  • Implant handling Excessive finger print contamination from handling, may produce slight discoloration after repeated steam autoclave cycles. No adverse effects are related to this change in surface appearance. Diagnostic imaging: X-radiography, magnetic resonance imaging and CT scans, and PET scans can be utilized. MRI scan resolution is superior to 316L stainless steel because titanium produces less starburst or signal interference.
  • Implants retrieval occasional back deposits (wear debris) may be observed at implant removal sites. No adverse tissue reaction is associated with this clinical observation.
  • the alloplastic component of this Titanium-collagen compound is made with unalloyed titanium. Thickness of this frame can vary between 0,1mm to 1.5 mm, they are designed to facilitate contouring and fixation with Standard 1.0mm. up to 2:30 mm., Titanium screws; different titanium chemical surface treatments can be used to increase the thickness of the naturally occurred titanium oxide film. Titanium surface can be rough or highly polished depending on the proposed clinical use for this Titanium-collagen compound. Size: It can be produced from small sizes 1 X 1 cm., up to the largest size of 25X25 cm.
  • the process of this invention involves specifically the following stages:
  • the intestine of porcines is obtained in accordance with the necessary requirements with regard to their raising, upbringing and upkeep to comply with the demands for them to be competent for this process to be performed. Attending the sacrifice of the animals and dissecting the abdomen, the yeyunum is then identified and approximately 1.5 to 2.5 meters of this is obtained. The intestine is then placed in a freezer for transport.
  • the membranes are stretched over sterile plastic on flat surfaces.
  • the sterilized titanium meshes of different sizes and designs are prepared that have been previously produced under the aforementioned international standards with different surface treatments in accordance with the use they will be given (Meshes with orifices of 1.0, 1.5, 2.0 and 2.3 mm., H, Y, half-moon shapes, etc.).
  • the membranes obtained in this manner are packaged, and cut within the sterile nucleus using guillotines and scissors for metal. They are transferred to the sterilization center with ethylene oxide.
  • the function of the container of filler materials with its origin not being of importance, is given by the collagen membrane, which due to its mechanical characteristics is capable of supporting tensions and pressures and of adapting to the relief given by the filler used. At the same time, it permits the passage in both directions of small molecules as nutrients that help maintain the viability of autologous grafts.
  • ii. Barrier the materials such as the collagen that function as a selective barrier impede the passage of cells through their pores to impede the mixing of tissues and organize the regeneration process.
  • the size of the pore of the collagen of the small intestinal submucose oscillates between 10 and 100 microns acting as a selective barrier that permits the passage only of nutrients through its pores.
  • Tri-dimensional Outlines the ductility of the titanium mesh makes it easily malleable to be molded in a tri-dimensional shape permitting the stability of the shapes.
  • the elasticity module of the collagen permits the compound to be deformed and manipulated in accordance with its needs.
  • the design of the meshes with orifices makes the material capable of being set with the use of screws to healthy osseous surfaces neighboring the defective area.
  • a material with a high module of elasticity will transfer less implant forces to the bone. Therefore, the mix of these two titanium and collagen materials will make the absorption of forces responsible for the reabsorption and deformation of grafts possible.
  • the systemic evaluation of the patient is always necessary, which determines that the condition of the patient is apt for the implantation of the membrane(s).
  • the use of membranes in patients with uncontrolled systemic diseases such as diabetes, lupus, a history of allergic reactions to porcine or collagen derivatives; in infected wounds or with any sign of infection is contraindicated.
  • the maximum load appeared to be affected by the number of layers, with it being significantly higher in the 4L group, when comparing it with the 1 L, 1oL and 2L groups; and in the 4T group, when comparing it with the 1T and 2T groups.
  • the direction of the highest load applied to the lesion should also be analyzed with the medical specialist with the aim of orienting the membrane longitudinally in that direction. Taking into consideration that the mechanical properties of the configuration of an overlapping simple layer are similar to the ones of a simple layer, it would also be possible to use configurations of overlapping layers for use in large-area lesions.
  • a planting of fibroblasts and keratinocytes on SIS membrane supports were conducted. They were incubated for four weeks at 37°C and 5% CO2.
  • a stress strain test was conducted in which a resistance to stress between 3.5 and 19.45 MPa were obtained, and the viscous-elastic behavior of the material was evidenced. The values found for the sown supports were greater than those found for the control models (exposed to a cell-free medium in the same conditions as the sown supports).
  • the group was comprised of 29 women and 16 men ranging in age from 21 to 76 years with an average age of 48.5 years.
  • the bone defects were classified into four different groups: trauma defects (6), by infection (8), by atrophy (31) and by mechanical apparatus (1 ).
  • Panoramic and periapical radiographies of the defects in the preoperative, in the immediate postoperative period and three and six months later were taken of each of the patients.
  • the evaluation of the radiographic changes were conducted in accordance with the surgeon's criterion.
  • the patients were evaluated to measure acute systemic toxicity observing any related sign or symptom such as general discomfort, diarrhea and vomiting.
  • the pyrogenicity of the material was evaluated taking body temperature readings using a standardized monitor for vital signs. Body temperature readings were taken immediately before the surgery and on the fifth postoperative day.
  • the allergic response to the material was evaluated analyzing in situ changes and searching for any type of changes at the systemic level such as pruritus, urticaria and skin eczema, etc., that would suggest a clinical chart of allergic reactions.
  • the collagen membranes were implanted in 30 patients with cutaneous ulcers following the protocol described in this document for the use of the membranes in plastic and reconstructive surgery. Complete closure of all the wounds was obtained.
  • a A methodology for the isolation and purification of the collagen.
  • b A methodology for purified small intestinal submucose collagen adhesion onto a titanium structure.
  • c Design of several different collagen structures in many thickness that varies it's biomechanical features, making it possible for the device to have clinical versatility.
  • d Collagen-Titanium compound variations based on thickness and proportional changes of both collagen and titanium materials.
  • e Clinical applications for the use of the collagen membranes reinforced with a titanium frame
  • the present invention provides a new alternative for tissue remodeling and reconstruction, using intestinal submucose membranes that contain a titanium mesh which will make them capable of supporting compression and tension loads, imitating tri-dimensional geometric shapes
  • This device makes possible for this material (collagens) to maintain its demonstrated biological qualities, such as its excellent regenerative capacity.
  • the device of the present invention intended for guided tissue regeneration is applicable in several fields of reconstructive surgery, where this characteristic provided by the Titanium frame is required, in order to be molded, to support loads and to be set.
  • the innovative device of the present invention will function as a container capable of maintaining the tri-dimensional shape that it's molded into, and as a barrier to impede the penetration of cells that are different than those that are grafted within the matrix.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Materials Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Composite Materials (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)

Abstract

La présente invention concerne un dispositif applicable dans le domaine de la santé médicale, en particulier, la présente invention est applicable dans tous les types d'opérations nécessitant la régénération des tissus chez un patient. La présente invention concerne spécifiquement un nouveau dispositif pour la régénération des tissus consistant en membranes de collagène provenant de la sous-muqueuse intestinale renforcées avec une maille en titane de telle sorte que les deux matériaux sont intégrés pour former le dispositif. Ce dispositif régénérateur de tissu peut avoir des variations en épaisseur, autant dans le composant biologique produit par les membranes de collagène provenant de la sous-muqueuse intestinale que dans le composant alloplastique fabriqué en titane. Le nouveau dispositif décrit ici peut être utilisé de manière simple et efficace dans diverses applications chirurgicales ayant à voir avec la régénération de divers tissus d'un patient, étant donné qu'il contribue à un processus de guérison ordonné, rapide et efficace et qu'il aide à remplacer les parties du corps qui ont souffert de graves traumatismes suite à des maladies ou à des accidents, leur redonnant le plus grand pourcentage de fonction et d'esthétique perdues. De même, le dispositif prévoit une nouvelle option pour le remodelage et la reconstruction des tissus selon sa structure et sa composition. De plus, la présente invention prévoit un procédé pour la préparation du nouveau dispositif, caractérisé par des étapes spécifiques et des conditions nécessaires pour l'obtenir.
PCT/IB2008/001922 2007-05-18 2008-07-14 Dispositif de régénération de tissu basé sur le collagène et procédé pour la production de ce dispositif WO2009047598A2 (fr)

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CO07-049.9413 2007-05-18
CO07049941 2007-05-18

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113520638A (zh) * 2021-06-18 2021-10-22 佳木斯大学 用于牙槽骨增量的钛网的设计及制作方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1656959A2 (fr) * 2004-11-12 2006-05-17 DePuy Products, Inc. Système pour l'attachement de tissu mou à un implant
WO2007028052A2 (fr) * 2005-09-01 2007-03-08 Cook Incorporated Fixation de materiau a un cadre implantable par reticulation
WO2007035791A2 (fr) * 2005-09-19 2007-03-29 Cook Incorporated Greffon avec structure de maintien bioabsorbable

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1656959A2 (fr) * 2004-11-12 2006-05-17 DePuy Products, Inc. Système pour l'attachement de tissu mou à un implant
WO2007028052A2 (fr) * 2005-09-01 2007-03-08 Cook Incorporated Fixation de materiau a un cadre implantable par reticulation
WO2007035791A2 (fr) * 2005-09-19 2007-03-29 Cook Incorporated Greffon avec structure de maintien bioabsorbable

Non-Patent Citations (1)

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Title
JULIETTE VAN DEN DOLDER AND JOHN A JANSEN ED - BRONNER FELIX: "Titanium Fiber Mesh: A Nondegradable Scaffold Material", 14 March 2007 (2007-03-14), ENGINEERING OF FUNCTIONAL SKELETAL TISSUES, LONDON : SPRINGER, GB, PAGE(S) 69 - 80, XP008137686, ISBN: 1-85233-962-4 page 68-80, [retrieved on 2007-03-14] page 69 page 74, column 2, paragraph 3 - page 75, column 2, paragraph 1 page 78, column 2, paragraph 2 - page 79, column 1, paragraph 2 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113520638A (zh) * 2021-06-18 2021-10-22 佳木斯大学 用于牙槽骨增量的钛网的设计及制作方法

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