WO2009047303A3 - Metabotropic glutamate receptor modulators for the treatment of pervasive developmental disorder - Google Patents

Metabotropic glutamate receptor modulators for the treatment of pervasive developmental disorder Download PDF

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Publication number
WO2009047303A3
WO2009047303A3 PCT/EP2008/063553 EP2008063553W WO2009047303A3 WO 2009047303 A3 WO2009047303 A3 WO 2009047303A3 EP 2008063553 W EP2008063553 W EP 2008063553W WO 2009047303 A3 WO2009047303 A3 WO 2009047303A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
pervasive developmental
developmental disorder
receptor modulators
glutamate receptor
Prior art date
Application number
PCT/EP2008/063553
Other languages
French (fr)
Other versions
WO2009047303A2 (en
Inventor
Daniel Umbricht
Baltazar Gomez-Mancilla
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of WO2009047303A2 publication Critical patent/WO2009047303A2/en
Publication of WO2009047303A3 publication Critical patent/WO2009047303A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention concerns the use an mGluR modulator, e.g. an mGluR5 modulator, for the treatment, prevention or delay of progression of a pervasive developmental disorder. The invention further concerns the use of an mGluR modulator for the treatment, prevention or delay of progression of a disorder is selected from Fragile X syndrome and fragile X- associated tremor/ataxia syndrome (FXTAS).
PCT/EP2008/063553 2007-10-12 2008-10-09 Metabotropic glutamate receptor modulators for the treatment of pervasive developmental disorder WO2009047303A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97949107P 2007-10-12 2007-10-12
US60/979,491 2007-10-12

Publications (2)

Publication Number Publication Date
WO2009047303A2 WO2009047303A2 (en) 2009-04-16
WO2009047303A3 true WO2009047303A3 (en) 2009-08-27

Family

ID=40349986

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/063553 WO2009047303A2 (en) 2007-10-12 2008-10-09 Metabotropic glutamate receptor modulators for the treatment of pervasive developmental disorder

Country Status (1)

Country Link
WO (1) WO2009047303A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8853392B2 (en) 2007-06-03 2014-10-07 Vanderbilt University Benzamide mGluR5 positive allosteric modulators and methods of making and using same
US8034806B2 (en) 2007-11-02 2011-10-11 Vanderbilt University Bicyclic mGluR5 positive allosteric modulators and methods of making and using same
WO2012084873A1 (en) * 2010-12-20 2012-06-28 Novartis Ag 4- (hetero) aryl - ethynyl - octahydro - indole - 1 - carboxylic acid esters
CN106187838B (en) * 2016-07-13 2018-05-01 广东东阳光药业有限公司 Aryl alkynes compound and its preparation method and application

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030100539A1 (en) * 2001-04-02 2003-05-29 Bear Mark F. Methods of treating neurological disorders with group I mGluR antagonists
WO2006094639A1 (en) * 2005-03-04 2006-09-14 F.Hoffmann-La Roche Ag Pyridine-2-carboxamide derivatives as mglur5 antagonists
WO2006114262A1 (en) * 2005-04-25 2006-11-02 Novartis Ag Acetylene derivatives
WO2006114260A1 (en) * 2005-04-25 2006-11-02 Novartis Ag Phenylacetylene derivatives having mglur5 receptor affinity
WO2007021575A2 (en) * 2005-08-15 2007-02-22 Astrazeneca Ab Acetylenic piperazines as metabotropic glutamate receptor antagonists
WO2007071358A1 (en) * 2005-12-20 2007-06-28 Novartis Ag Nicotinic acid derivatives as modulators of metabotropic glutamate receptors

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030100539A1 (en) * 2001-04-02 2003-05-29 Bear Mark F. Methods of treating neurological disorders with group I mGluR antagonists
WO2006094639A1 (en) * 2005-03-04 2006-09-14 F.Hoffmann-La Roche Ag Pyridine-2-carboxamide derivatives as mglur5 antagonists
WO2006114262A1 (en) * 2005-04-25 2006-11-02 Novartis Ag Acetylene derivatives
WO2006114260A1 (en) * 2005-04-25 2006-11-02 Novartis Ag Phenylacetylene derivatives having mglur5 receptor affinity
WO2007021575A2 (en) * 2005-08-15 2007-02-22 Astrazeneca Ab Acetylenic piperazines as metabotropic glutamate receptor antagonists
WO2007071358A1 (en) * 2005-12-20 2007-06-28 Novartis Ag Nicotinic acid derivatives as modulators of metabotropic glutamate receptors

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BEERS M H ET AL: "Pervasive developmental disorders spectrum", THE MERCK MANUAL OF DIAGNOSIS AND THERAPY, WHITEHOUSE STATION, N.J. : MERCK RESEARCH LABORATORIES, vol. 18Eds, 1 January 2006 (2006-01-01), pages 2487, XP002516054, ISBN: 978-0-911910-18-6 *
DÖLEN GÜL ET AL: "Courting a cure for fragile X.", NEURON 3 MAR 2005, vol. 45, no. 5, 3 March 2005 (2005-03-03), pages 642 - 644, XP002516059, ISSN: 0896-6273 *
MCBRIDE SEAN M J ET AL: "Pharmacological rescue of synaptic plasticity, courtship behavior, and mushroom body defects in a Drosophila model of fragile X syndrome.", NEURON 3 MAR 2005, vol. 45, no. 5, 3 March 2005 (2005-03-03), pages 753 - 764, XP002516058, ISSN: 0896-6273 *

Also Published As

Publication number Publication date
WO2009047303A2 (en) 2009-04-16

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