WO2009047045A3 - Bioreactor for generation and complex mechanical stimulation of engineered biological tissue - Google Patents

Bioreactor for generation and complex mechanical stimulation of engineered biological tissue Download PDF

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Publication number
WO2009047045A3
WO2009047045A3 PCT/EP2008/061338 EP2008061338W WO2009047045A3 WO 2009047045 A3 WO2009047045 A3 WO 2009047045A3 EP 2008061338 W EP2008061338 W EP 2008061338W WO 2009047045 A3 WO2009047045 A3 WO 2009047045A3
Authority
WO
WIPO (PCT)
Prior art keywords
bioreactor
generation
biological tissue
mechanical stimulation
complex mechanical
Prior art date
Application number
PCT/EP2008/061338
Other languages
French (fr)
Other versions
WO2009047045A2 (en
Inventor
Katia Lagana`
Manuela Teresa Raimondi
Gabriele Dubini
Rosaria Santoro
Original Assignee
Politecnico Di Milano
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Politecnico Di Milano filed Critical Politecnico Di Milano
Publication of WO2009047045A2 publication Critical patent/WO2009047045A2/en
Publication of WO2009047045A3 publication Critical patent/WO2009047045A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14—Scaffolds; Matrices
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/34—Internal compartments or partitions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Sustainable Development (AREA)
  • Clinical Laboratory Science (AREA)
  • Immunology (AREA)
  • Mechanical Engineering (AREA)
  • Cell Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)

Abstract

A bioreactor for generation and complex mechanical stimulation of engineered biological tissue comprises a body (2) defining a culture chamber (3) which is adapted to be filled with a culture liquid in which a scaffold is supported. Advantageously, two opposed pistons (5, 6) are slideably received into said body (2) to cover a predetermined operating stroke in the culture chamber (3) from a retracted position to a forward position and operate on the volume (3) of the culture chamber (3), said scaffold being interposed between the two ends of the pistons (5, 6).
PCT/EP2008/061338 2007-10-09 2008-08-28 Bioreactor for generation and complex mechanical stimulation of engineered biological tissue. WO2009047045A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI20071945 ITMI20071945A1 (en) 2007-10-09 2007-10-09 BIOREACTOR FOR THE GENERATION AND MECHANICAL COMPLEX STIMULATION OF ENGINEERED BIOLOGICAL FABRIC.
ITMI2007A001945 2007-10-09

Publications (2)

Publication Number Publication Date
WO2009047045A2 WO2009047045A2 (en) 2009-04-16
WO2009047045A3 true WO2009047045A3 (en) 2010-01-14

Family

ID=40313789

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/061338 WO2009047045A2 (en) 2007-10-09 2008-08-28 Bioreactor for generation and complex mechanical stimulation of engineered biological tissue.

Country Status (2)

Country Link
IT (1) ITMI20071945A1 (en)
WO (1) WO2009047045A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT106827B (en) * 2013-03-11 2015-03-11 Univ Aveiro STIMULATOR BIOREATOR FOR BIOMECHANICAL CHARACTERIZATION OF TISSUE ENGINEERING
US9670443B2 (en) 2014-06-25 2017-06-06 University Of Leeds Tissue engineered constructs
EP3498310A1 (en) * 2017-12-18 2019-06-19 Tornier In vitro method for creating a viable connective tissue and/or osseous tissue
US11230793B2 (en) 2019-10-08 2022-01-25 Applied Materials, Inc. Mechanically-driven oscillating flow agitation
IT201900022350A1 (en) * 2019-12-04 2021-06-04 Hydra S R L DEVICE FOR TISSUE FRAGMENTATION IN A CLOSED STERILE ENVIRONMENT WITH ASEPTIC PROCEDURE AND ITS METHOD

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6060306A (en) * 1995-06-07 2000-05-09 Advanced Tissue Sciences, Inc. Apparatus and method for sterilizing, seeding, culturing, storing, shipping and testing replacement cartilage tissue constructs
US20010043918A1 (en) * 2000-05-05 2001-11-22 Masini Michael A. In vitro mechanical loading of musculoskeletal tissues
EP1428869A1 (en) * 2001-08-30 2004-06-16 Takagi Industrial Co., Ltd. Cell and structure incubator
EP1462515A1 (en) * 2001-12-05 2004-09-29 Takagi Industrial Co., Ltd. Cell/tissue culture apparatus
US20050069426A1 (en) * 2002-03-26 2005-03-31 Christopher Mason Devices for use in medicine
WO2005040332A2 (en) * 2003-10-21 2005-05-06 Universität Leipzig Method and bioreactor for the cultivation and stimulation of three-dimensional vital and mechanically-resistant cell transplants

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6060306A (en) * 1995-06-07 2000-05-09 Advanced Tissue Sciences, Inc. Apparatus and method for sterilizing, seeding, culturing, storing, shipping and testing replacement cartilage tissue constructs
US20010043918A1 (en) * 2000-05-05 2001-11-22 Masini Michael A. In vitro mechanical loading of musculoskeletal tissues
EP1428869A1 (en) * 2001-08-30 2004-06-16 Takagi Industrial Co., Ltd. Cell and structure incubator
EP1462515A1 (en) * 2001-12-05 2004-09-29 Takagi Industrial Co., Ltd. Cell/tissue culture apparatus
US20050069426A1 (en) * 2002-03-26 2005-03-31 Christopher Mason Devices for use in medicine
WO2005040332A2 (en) * 2003-10-21 2005-05-06 Universität Leipzig Method and bioreactor for the cultivation and stimulation of three-dimensional vital and mechanically-resistant cell transplants

Also Published As

Publication number Publication date
ITMI20071945A1 (en) 2009-04-10
WO2009047045A2 (en) 2009-04-16

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