WO2009047045A3 - Bioreactor for generation and complex mechanical stimulation of engineered biological tissue - Google Patents

Bioreactor for generation and complex mechanical stimulation of engineered biological tissue Download PDF

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Publication number
WO2009047045A3
WO2009047045A3 PCT/EP2008/061338 EP2008061338W WO2009047045A3 WO 2009047045 A3 WO2009047045 A3 WO 2009047045A3 EP 2008061338 W EP2008061338 W EP 2008061338W WO 2009047045 A3 WO2009047045 A3 WO 2009047045A3
Authority
WO
Grant status
Application
Patent type
Prior art keywords
bioreactor
generation
biological tissue
mechanical stimulation
complex mechanical
Prior art date
Application number
PCT/EP2008/061338
Other languages
French (fr)
Other versions
WO2009047045A2 (en )
Inventor
Katia Lagana`
Manuela Teresa Raimondi
Gabriele Dubini
Rosaria Santoro
Original Assignee
Politecnico Di Milano
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14Scaffolds; Matrices
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/34Internal compartments or partitions
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/04Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli

Abstract

A bioreactor for generation and complex mechanical stimulation of engineered biological tissue comprises a body (2) defining a culture chamber (3) which is adapted to be filled with a culture liquid in which a scaffold is supported. Advantageously, two opposed pistons (5, 6) are slideably received into said body (2) to cover a predetermined operating stroke in the culture chamber (3) from a retracted position to a forward position and operate on the volume (3) of the culture chamber (3), said scaffold being interposed between the two ends of the pistons (5, 6).
PCT/EP2008/061338 2007-10-09 2008-08-28 Bioreactor for generation and complex mechanical stimulation of engineered biological tissue WO2009047045A3 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
ITMI2007A001945 2007-10-09
ITMI20071945A1 ITMI20071945A1 (en) 2007-10-09 2007-10-09 Bioreactor for the generation and the complex mechanical stimulation of engineered biological tissue.

Publications (2)

Publication Number Publication Date
WO2009047045A2 true WO2009047045A2 (en) 2009-04-16
WO2009047045A3 true true WO2009047045A3 (en) 2010-01-14

Family

ID=40313789

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/061338 WO2009047045A3 (en) 2007-10-09 2008-08-28 Bioreactor for generation and complex mechanical stimulation of engineered biological tissue

Country Status (1)

Country Link
WO (1) WO2009047045A3 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9670443B2 (en) * 2014-06-25 2017-06-06 University Of Leeds Tissue engineered constructs

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6060306A (en) * 1995-06-07 2000-05-09 Advanced Tissue Sciences, Inc. Apparatus and method for sterilizing, seeding, culturing, storing, shipping and testing replacement cartilage tissue constructs
US20010043918A1 (en) * 2000-05-05 2001-11-22 Masini Michael A. In vitro mechanical loading of musculoskeletal tissues
EP1428869A1 (en) * 2001-08-30 2004-06-16 TAKAGI INDUSTRIES CO., Ltd. Cell and structure incubator
EP1462515A1 (en) * 2001-12-05 2004-09-29 TAKAGI INDUSTRIES CO., Ltd. Cell/tissue culture apparatus
US20050069426A1 (en) * 2002-03-26 2005-03-31 Christopher Mason Devices for use in medicine
WO2005040332A2 (en) * 2003-10-21 2005-05-06 Universität Leipzig Method and bioreactor for the cultivation and stimulation of three-dimensional vital and mechanically-resistant cell transplants

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6060306A (en) * 1995-06-07 2000-05-09 Advanced Tissue Sciences, Inc. Apparatus and method for sterilizing, seeding, culturing, storing, shipping and testing replacement cartilage tissue constructs
US20010043918A1 (en) * 2000-05-05 2001-11-22 Masini Michael A. In vitro mechanical loading of musculoskeletal tissues
EP1428869A1 (en) * 2001-08-30 2004-06-16 TAKAGI INDUSTRIES CO., Ltd. Cell and structure incubator
EP1462515A1 (en) * 2001-12-05 2004-09-29 TAKAGI INDUSTRIES CO., Ltd. Cell/tissue culture apparatus
US20050069426A1 (en) * 2002-03-26 2005-03-31 Christopher Mason Devices for use in medicine
WO2005040332A2 (en) * 2003-10-21 2005-05-06 Universität Leipzig Method and bioreactor for the cultivation and stimulation of three-dimensional vital and mechanically-resistant cell transplants

Also Published As

Publication number Publication date Type
WO2009047045A2 (en) 2009-04-16 application

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