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WO2009047045A3 - Bioreactor for generation and complex mechanical stimulation of engineered biological tissue - Google Patents

Bioreactor for generation and complex mechanical stimulation of engineered biological tissue

Info

Publication number
WO2009047045A3
WO2009047045A3 PCT/EP2008/061338 EP2008061338W WO2009047045A3 WO 2009047045 A3 WO2009047045 A3 WO 2009047045A3 EP 2008061338 W EP2008061338 W EP 2008061338W WO 2009047045 A3 WO2009047045 A3 WO 2009047045A3
Authority
WO
Grant status
Application
Patent type
Prior art keywords
culture
chamber
body
mechanical
pistons
Prior art date
Application number
PCT/EP2008/061338
Other languages
French (fr)
Other versions
WO2009047045A2 (en )
Inventor
Katia Lagana`
Manuela Teresa Raimondi
Gabriele Dubini
Rosaria Santoro
Original Assignee
Politecnico Di Milano
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14Scaffolds; Matrices
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/34Internal compartments or partitions
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/04Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli

Abstract

A bioreactor for generation and complex mechanical stimulation of engineered biological tissue comprises a body (2) defining a culture chamber (3) which is adapted to be filled with a culture liquid in which a scaffold is supported. Advantageously, two opposed pistons (5, 6) are slideably received into said body (2) to cover a predetermined operating stroke in the culture chamber (3) from a retracted position to a forward position and operate on the volume (3) of the culture chamber (3), said scaffold being interposed between the two ends of the pistons (5, 6).
PCT/EP2008/061338 2007-10-09 2008-08-28 Bioreactor for generation and complex mechanical stimulation of engineered biological tissue WO2009047045A3 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
ITMI2007A001945 2007-10-09
ITMI20071945 2007-10-09

Publications (2)

Publication Number Publication Date
WO2009047045A2 true WO2009047045A2 (en) 2009-04-16
WO2009047045A3 true true WO2009047045A3 (en) 2010-01-14

Family

ID=40313789

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/061338 WO2009047045A3 (en) 2007-10-09 2008-08-28 Bioreactor for generation and complex mechanical stimulation of engineered biological tissue

Country Status (1)

Country Link
WO (1) WO2009047045A3 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9670443B2 (en) 2014-06-25 2017-06-06 University Of Leeds Tissue engineered constructs

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6060306A (en) * 1995-06-07 2000-05-09 Advanced Tissue Sciences, Inc. Apparatus and method for sterilizing, seeding, culturing, storing, shipping and testing replacement cartilage tissue constructs
US20010043918A1 (en) * 2000-05-05 2001-11-22 Masini Michael A. In vitro mechanical loading of musculoskeletal tissues
EP1428869A1 (en) * 2001-08-30 2004-06-16 TAKAGI INDUSTRIES CO., Ltd. Cell and structure incubator
EP1462515A1 (en) * 2001-12-05 2004-09-29 TAKAGI INDUSTRIES CO., Ltd. Cell/tissue culture apparatus
US20050069426A1 (en) * 2002-03-26 2005-03-31 Christopher Mason Devices for use in medicine
WO2005040332A2 (en) * 2003-10-21 2005-05-06 Universität Leipzig Method and bioreactor for the cultivation and stimulation of three-dimensional vital and mechanically-resistant cell transplants

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6060306A (en) * 1995-06-07 2000-05-09 Advanced Tissue Sciences, Inc. Apparatus and method for sterilizing, seeding, culturing, storing, shipping and testing replacement cartilage tissue constructs
US20010043918A1 (en) * 2000-05-05 2001-11-22 Masini Michael A. In vitro mechanical loading of musculoskeletal tissues
EP1428869A1 (en) * 2001-08-30 2004-06-16 TAKAGI INDUSTRIES CO., Ltd. Cell and structure incubator
EP1462515A1 (en) * 2001-12-05 2004-09-29 TAKAGI INDUSTRIES CO., Ltd. Cell/tissue culture apparatus
US20050069426A1 (en) * 2002-03-26 2005-03-31 Christopher Mason Devices for use in medicine
WO2005040332A2 (en) * 2003-10-21 2005-05-06 Universität Leipzig Method and bioreactor for the cultivation and stimulation of three-dimensional vital and mechanically-resistant cell transplants

Also Published As

Publication number Publication date Type
WO2009047045A2 (en) 2009-04-16 application

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