WO2009045412A3 - Methods of treatment using modified plasminogen activator inhibitor type-1 molecules - Google Patents

Methods of treatment using modified plasminogen activator inhibitor type-1 molecules Download PDF

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Publication number
WO2009045412A3
WO2009045412A3 PCT/US2008/011330 US2008011330W WO2009045412A3 WO 2009045412 A3 WO2009045412 A3 WO 2009045412A3 US 2008011330 W US2008011330 W US 2008011330W WO 2009045412 A3 WO2009045412 A3 WO 2009045412A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
plasminogen activator
activator inhibitor
molecules
inhibitor type
Prior art date
Application number
PCT/US2008/011330
Other languages
French (fr)
Other versions
WO2009045412A2 (en
Inventor
Jerzy Jankun
Ewa Skrzypczak-Jankun
Steven H. Selman
Robert S. Greenfield
Original Assignee
American Diagnostica, Inc.
The University Of Toledo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Diagnostica, Inc., The University Of Toledo filed Critical American Diagnostica, Inc.
Publication of WO2009045412A2 publication Critical patent/WO2009045412A2/en
Publication of WO2009045412A3 publication Critical patent/WO2009045412A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Abstract

The present invention generally relates to methods of treating bleeding diseases and disorders and to promote wound healing. The methods comprises administering a procoagulant, preferably factor VII a, and a modified plasminogen activator inhibitor type-1 (PAI-1) molecule that displays an increased in vivo half-life of the active form of the PAI-1 molecule. The invention also relates to methods of treating respiratory diseases using a modified PAI-1 molecule.
PCT/US2008/011330 2007-10-01 2008-10-01 Methods of treatment using modified plasminogen activator inhibitor type-1 molecules WO2009045412A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97665107P 2007-10-01 2007-10-01
US60/976,651 2007-10-01

Publications (2)

Publication Number Publication Date
WO2009045412A2 WO2009045412A2 (en) 2009-04-09
WO2009045412A3 true WO2009045412A3 (en) 2010-01-21

Family

ID=40526878

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/011330 WO2009045412A2 (en) 2007-10-01 2008-10-01 Methods of treatment using modified plasminogen activator inhibitor type-1 molecules

Country Status (1)

Country Link
WO (1) WO2009045412A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2150273A4 (en) * 2007-04-27 2010-11-17 Univ Toledo Modified plasminogen activator inhibitor type-1 molecule and methods based thereon
CN106212126A (en) * 2016-08-11 2016-12-14 邱文娟 A kind of prevention and controls of Fructus Pruni pseudocerasi bleeding disease

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997039028A1 (en) * 1996-04-12 1997-10-23 American National Red Cross Mutant plasminogen activator-inhibitor type 1 (pai-1) and uses thereof
WO1998058661A1 (en) * 1997-06-23 1998-12-30 Novo Nordisk A/S Use of fviia for the treatment of bleedings in patients with a normal blood clotting cascade and normal platelet function
WO2003039580A1 (en) * 2001-11-09 2003-05-15 Novo Nordisk Health Care Ag Pharmaceutical composition comprising factor vii polypeptides and pai-1 polypeptides
WO2003080646A2 (en) * 2002-03-04 2003-10-02 Medical College Of Ohio Modified plasminogen activator inhibitor type-1 and methods based thereon
WO2004056384A2 (en) * 2002-12-20 2004-07-08 Novo Nordisk Health Care Ag Use of factor vii polypeptides for preventing formation of inhibitors to blood coagulation factor viii and ix
WO2005107795A1 (en) * 2004-05-11 2005-11-17 Novo Nordisk Health Care Ag Use of factor viia for the treatment of burn traumas

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997039028A1 (en) * 1996-04-12 1997-10-23 American National Red Cross Mutant plasminogen activator-inhibitor type 1 (pai-1) and uses thereof
WO1998058661A1 (en) * 1997-06-23 1998-12-30 Novo Nordisk A/S Use of fviia for the treatment of bleedings in patients with a normal blood clotting cascade and normal platelet function
WO2003039580A1 (en) * 2001-11-09 2003-05-15 Novo Nordisk Health Care Ag Pharmaceutical composition comprising factor vii polypeptides and pai-1 polypeptides
WO2003080646A2 (en) * 2002-03-04 2003-10-02 Medical College Of Ohio Modified plasminogen activator inhibitor type-1 and methods based thereon
WO2004056384A2 (en) * 2002-12-20 2004-07-08 Novo Nordisk Health Care Ag Use of factor vii polypeptides for preventing formation of inhibitors to blood coagulation factor viii and ix
WO2005107795A1 (en) * 2004-05-11 2005-11-17 Novo Nordisk Health Care Ag Use of factor viia for the treatment of burn traumas

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CATE JACQUELINE M ET AL: "Structure-function relationships of plasminogen activator inhibitor-1 and its potential as a therapeutic agent", CURRENT DRUG TARGETS, vol. 8, no. 9, September 2007 (2007-09-01), pages 971 - 981, XP008115249, ISSN: 1389-4501 *
DE TAEYE B ET AL: "The story of the serpin plasminogen activator inhibitor I: Is there any need for another mutant?", THROMBOSIS AND HAEMOSTASIS 200411 DE, vol. 92, no. 5, November 2004 (2004-11-01), pages 898 - 924, XP008115403, ISSN: 0340-6245 *
RENCKENS ROSEMARIJN ET AL: "Plasminogen activator inhibitor type 1 is protective during severe Gram-negative pneumonia", BLOOD, vol. 109, no. 4, February 2007 (2007-02-01), pages 1593 - 1601, XP002557166, ISSN: 0006-4971 *
SISSON T H ET AL: "The plasminogen activation system in lung disease", CURRENT DRUG TARGETS 200709 NL, vol. 8, no. 9, September 2007 (2007-09-01), pages 1016 - 1029, XP008115250, ISSN: 1389-4501 *

Also Published As

Publication number Publication date
WO2009045412A2 (en) 2009-04-09

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