WO2009043940A3 - Peptides with high affinity for the prolactin receptor - Google Patents
Peptides with high affinity for the prolactin receptor Download PDFInfo
- Publication number
- WO2009043940A3 WO2009043940A3 PCT/EP2008/063337 EP2008063337W WO2009043940A3 WO 2009043940 A3 WO2009043940 A3 WO 2009043940A3 EP 2008063337 W EP2008063337 W EP 2008063337W WO 2009043940 A3 WO2009043940 A3 WO 2009043940A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- peptides
- prolactin receptor
- high affinity
- prolactin
- receptor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57554—Prolactin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The present invention is concerned with peptides binding to the prolactin receptor, wherein said peptides have an improved binding via binding site 1 (BS1) to the prolactin receptor, particularly variants of human prolactin comprising one or more amino acid mutations in the positions corresponding to positions 21, 36, 38, 42, 93, 97, 130, 135, 157 and 166 of human prolactin.
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07117953 | 2007-10-05 | ||
EP07117953.5 | 2007-10-05 | ||
EP08101600 | 2008-02-13 | ||
EP08101600.8 | 2008-02-13 | ||
EP08101620.6 | 2008-02-14 | ||
EP08101620 | 2008-02-14 | ||
EPPCT/EP2008/052784 | 2008-03-07 | ||
PCT/EP2008/052784 WO2009003732A2 (en) | 2007-07-05 | 2008-03-07 | Peptides with high affinity for the prolactin receptor |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009043940A2 WO2009043940A2 (en) | 2009-04-09 |
WO2009043940A3 true WO2009043940A3 (en) | 2009-09-17 |
Family
ID=40042983
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2008/063337 WO2009043940A2 (en) | 2007-10-05 | 2008-10-06 | Peptides with high affinity for the prolactin receptor |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2009043940A2 (en) |
-
2008
- 2008-10-06 WO PCT/EP2008/063337 patent/WO2009043940A2/en active Application Filing
Non-Patent Citations (7)
Title |
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CUNNINGHAM B C ET AL: "RATIONAL DESIGN OF RECEPTOR-SPECIFIC VARIANTS OF HUMAN GROWTH HORMONE", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC.; US, vol. 88, no. 8, 15 April 1991 (1991-04-15), pages 3407 - 3411, XP000202315, ISSN: 0027-8424 * |
GOFFIN V ET AL: "Alanine-scanning mutagenesis of human prolactin: importance of the 58-74 region for bioactivity", MOLECULAR ENDOCRINOLOGY, BALTIMORE, MD, US, vol. 6, no. 9, 1 September 1992 (1992-09-01), pages 1381 - 1392, XP002462852, ISSN: 0888-8809 * |
GOFFIN V ET AL: "Development and potential clinical uses of human prolactin receptor antagonists", ENDOCRINE REVIEWS, BALTIMORE, MD, US, vol. 26, no. 3, 6 April 2005 (2005-04-06), pages 400 - 422, XP002408797 * |
GOFFIN V ET AL: "EVIDENCE FOR A SECOND RECEPTOR BINDING SITE ON HUMAN PROLACTIN", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,; US, vol. 269, no. 51, 23 December 1994 (1994-12-23), pages 32598 - 32602, XP002921794, ISSN: 0021-9258 * |
GOFFIN V ET AL: "The human growth hormone antagonist B2036 does not interact with the prolactin receptor", ENDOCRINOLOGY, BALTIMORE, MD, US, vol. 140, no. 8, 1 August 1999 (1999-08-01), pages 3853 - 3856, XP002381487, ISSN: 0013-7227 * |
KINET S ET AL: "Characterization of Lactogen Receptor Binding Site 1 of Human Prolactin", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,; US, vol. 271, no. 24, 14 June 1996 (1996-06-14), pages 14353 - 14360, XP002988936, ISSN: 0021-9258 * |
TEILUM ET AL: "Solution Structure of Human Prolactin", JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB, vol. 351, no. 4, 26 August 2005 (2005-08-26), pages 810 - 823, XP005004660, ISSN: 0022-2836 * |
Also Published As
Publication number | Publication date |
---|---|
WO2009043940A2 (en) | 2009-04-09 |
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