WO2009043940A3 - Peptides with high affinity for the prolactin receptor - Google Patents

Peptides with high affinity for the prolactin receptor Download PDF

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Publication number
WO2009043940A3
WO2009043940A3 PCT/EP2008/063337 EP2008063337W WO2009043940A3 WO 2009043940 A3 WO2009043940 A3 WO 2009043940A3 EP 2008063337 W EP2008063337 W EP 2008063337W WO 2009043940 A3 WO2009043940 A3 WO 2009043940A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptides
prolactin receptor
high affinity
prolactin
receptor
Prior art date
Application number
PCT/EP2008/063337
Other languages
French (fr)
Other versions
WO2009043940A2 (en
Inventor
Yun Liu
Wei Gong
Lingyun Wang
Original Assignee
Novo Nordisk A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2008/052784 external-priority patent/WO2009003732A2/en
Application filed by Novo Nordisk A/S filed Critical Novo Nordisk A/S
Publication of WO2009043940A2 publication Critical patent/WO2009043940A2/en
Publication of WO2009043940A3 publication Critical patent/WO2009043940A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57554—Prolactin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention is concerned with peptides binding to the prolactin receptor, wherein said peptides have an improved binding via binding site 1 (BS1) to the prolactin receptor, particularly variants of human prolactin comprising one or more amino acid mutations in the positions corresponding to positions 21, 36, 38, 42, 93, 97, 130, 135, 157 and 166 of human prolactin.
PCT/EP2008/063337 2007-10-05 2008-10-06 Peptides with high affinity for the prolactin receptor WO2009043940A2 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
EP07117953 2007-10-05
EP07117953.5 2007-10-05
EP08101600 2008-02-13
EP08101600.8 2008-02-13
EP08101620.6 2008-02-14
EP08101620 2008-02-14
EPPCT/EP2008/052784 2008-03-07
PCT/EP2008/052784 WO2009003732A2 (en) 2007-07-05 2008-03-07 Peptides with high affinity for the prolactin receptor

Publications (2)

Publication Number Publication Date
WO2009043940A2 WO2009043940A2 (en) 2009-04-09
WO2009043940A3 true WO2009043940A3 (en) 2009-09-17

Family

ID=40042983

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/063337 WO2009043940A2 (en) 2007-10-05 2008-10-06 Peptides with high affinity for the prolactin receptor

Country Status (1)

Country Link
WO (1) WO2009043940A2 (en)

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
CUNNINGHAM B C ET AL: "RATIONAL DESIGN OF RECEPTOR-SPECIFIC VARIANTS OF HUMAN GROWTH HORMONE", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC.; US, vol. 88, no. 8, 15 April 1991 (1991-04-15), pages 3407 - 3411, XP000202315, ISSN: 0027-8424 *
GOFFIN V ET AL: "Alanine-scanning mutagenesis of human prolactin: importance of the 58-74 region for bioactivity", MOLECULAR ENDOCRINOLOGY, BALTIMORE, MD, US, vol. 6, no. 9, 1 September 1992 (1992-09-01), pages 1381 - 1392, XP002462852, ISSN: 0888-8809 *
GOFFIN V ET AL: "Development and potential clinical uses of human prolactin receptor antagonists", ENDOCRINE REVIEWS, BALTIMORE, MD, US, vol. 26, no. 3, 6 April 2005 (2005-04-06), pages 400 - 422, XP002408797 *
GOFFIN V ET AL: "EVIDENCE FOR A SECOND RECEPTOR BINDING SITE ON HUMAN PROLACTIN", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,; US, vol. 269, no. 51, 23 December 1994 (1994-12-23), pages 32598 - 32602, XP002921794, ISSN: 0021-9258 *
GOFFIN V ET AL: "The human growth hormone antagonist B2036 does not interact with the prolactin receptor", ENDOCRINOLOGY, BALTIMORE, MD, US, vol. 140, no. 8, 1 August 1999 (1999-08-01), pages 3853 - 3856, XP002381487, ISSN: 0013-7227 *
KINET S ET AL: "Characterization of Lactogen Receptor Binding Site 1 of Human Prolactin", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,; US, vol. 271, no. 24, 14 June 1996 (1996-06-14), pages 14353 - 14360, XP002988936, ISSN: 0021-9258 *
TEILUM ET AL: "Solution Structure of Human Prolactin", JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB, vol. 351, no. 4, 26 August 2005 (2005-08-26), pages 810 - 823, XP005004660, ISSN: 0022-2836 *

Also Published As

Publication number Publication date
WO2009043940A2 (en) 2009-04-09

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