WO2009042621A3 - Injection system having microbubble-enhanced extravasation detection system - Google Patents

Injection system having microbubble-enhanced extravasation detection system Download PDF

Info

Publication number
WO2009042621A3
WO2009042621A3 PCT/US2008/077420 US2008077420W WO2009042621A3 WO 2009042621 A3 WO2009042621 A3 WO 2009042621A3 US 2008077420 W US2008077420 W US 2008077420W WO 2009042621 A3 WO2009042621 A3 WO 2009042621A3
Authority
WO
WIPO (PCT)
Prior art keywords
injection
subject
ultrasound
microbubbles
extravasation detection
Prior art date
Application number
PCT/US2008/077420
Other languages
French (fr)
Other versions
WO2009042621A2 (en
Inventor
Peter G Laitenberger
David M Pooley
Original Assignee
Mallinckrodt Inc
Peter G Laitenberger
David M Pooley
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc, Peter G Laitenberger, David M Pooley filed Critical Mallinckrodt Inc
Publication of WO2009042621A2 publication Critical patent/WO2009042621A2/en
Publication of WO2009042621A3 publication Critical patent/WO2009042621A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16831—Monitoring, detecting, signalling or eliminating infusion flow anomalies
    • A61M5/16836—Monitoring, detecting, signalling or eliminating infusion flow anomalies by sensing tissue properties at the infusion site, e.g. for detecting infiltration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
    • A61B8/0833—Detecting organic movements or changes, e.g. tumours, cysts, swellings involving detecting or locating foreign bodies or organic structures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
    • A61B8/0833—Detecting organic movements or changes, e.g. tumours, cysts, swellings involving detecting or locating foreign bodies or organic structures
    • A61B8/0841—Detecting organic movements or changes, e.g. tumours, cysts, swellings involving detecting or locating foreign bodies or organic structures for locating instruments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/329—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles characterised by features of the needle shaft
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
    • A61B8/4444—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device related to the probe
    • A61B8/4472—Wireless probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48—Diagnostic techniques
    • A61B8/481—Diagnostic techniques involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M2005/006—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests for gases, e.g. CO2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0068—Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
    • A61M2025/0073—Tip designed for influencing the flow or the flow velocity of the fluid, e.g. inserts for twisted or vortex flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3375—Acoustical, e.g. ultrasonic, measuring means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00—Characteristics of a physical parameter; associated device therefor
    • A61M2206/10—Flow characteristics
    • A61M2206/14—Static flow deviators in tubes disturbing laminar flow in tubes, e.g. archimedes screws
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0068—Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0082—Catheter tip comprising a tool
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/007—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests for contrast media
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)

Abstract

An injection system (101) includes a fluid delivery system for moving an injection medium along a flow path for injection thereof into a subject. The system (or a separate extravasation detection system(131)) has an ultrasound transducer (133) for detecting ultrasound energy reflected from inside the subject and an ultrasound contrast enhancement system for introducing microbubbles into the subject during the injection. The microbubbles increase reflectivity of one or more fluids in the subject to ultrasound energy, facilitating extravasation detection. A needle (143) or injection line may be constructed to produce the microbubbles during the injection, for example. In use, ultrasound is directed into the subject. Microbubbles are introduced into the subject during the injection to increase reflectivity of one or more fluids in the subject (181) to ultrasound. Ultrasound energy reflected from inside the subject is detected to obtain information indicative of whether or not the injection is extravasating or non-extravasating.
PCT/US2008/077420 2007-09-24 2008-09-24 Injection system having microbubble-enhanced extravasation detection system WO2009042621A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97449307P 2007-09-24 2007-09-24
US60/974,493 2007-09-24

Publications (2)

Publication Number Publication Date
WO2009042621A2 WO2009042621A2 (en) 2009-04-02
WO2009042621A3 true WO2009042621A3 (en) 2009-05-14

Family

ID=40394205

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/077420 WO2009042621A2 (en) 2007-09-24 2008-09-24 Injection system having microbubble-enhanced extravasation detection system

Country Status (1)

Country Link
WO (1) WO2009042621A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100995293B1 (en) * 2008-05-28 2010-11-19 주식회사 메디슨 Ultrasound system and method for detecting extravasation
GB2476623B (en) * 2008-11-06 2012-11-28 Neorad As Extravasation detection for fluid injection using dopppler ultrasound blood flow measurement
US20130338512A1 (en) 2012-03-12 2013-12-19 Ivwatch, Llc System and Method for Mitigating the Effects of Tissue Blood Volume Changes to Aid in Diagnosing Infiltration or Extravasation in Animalia Tissue
US20140155745A1 (en) * 2012-12-04 2014-06-05 Cook Medical Technologies, LLC Venturi Effect Mixing Catheter Apparatus and Methods of Using the Same
US9622719B2 (en) * 2013-02-26 2017-04-18 Allen Maizes Color ultrasound needle
US9101391B2 (en) 2013-11-11 2015-08-11 Cross Bay Medical, Inc. Apparatus and methods for accessing and sealing bodily vessels and cavities
US10245074B2 (en) 2013-11-11 2019-04-02 Crossbay Medical, Inc. Apparatus and methods for accessing and sealing bodily vessels and cavities
US10034986B2 (en) 2013-11-11 2018-07-31 Crossbay Medical, Inc. Method and apparatus of tubal patency catheter and delivery systems
US10543007B2 (en) 2017-03-31 2020-01-28 Medtronic Vascular, Inc. Cavitation catheter
US11141308B2 (en) 2017-08-31 2021-10-12 Crossbay Medical, Inc. Apparatus and method for everting catheter for IUD delivery and placement in the uterine cavity
US11623040B2 (en) * 2019-07-03 2023-04-11 Becton, Dickinson And Company Sensing catheters

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5271928A (en) * 1990-04-02 1993-12-21 Sintetica S.A. Stable microbubbles suspensions injectable into living organisms
US5733527A (en) * 1994-09-28 1998-03-31 Alliance Pharmaceutical Corp. Methods for harmonic imaging with ultrasound
WO1999027981A1 (en) * 1997-12-04 1999-06-10 Bracco Research S.A. Automatic liquid injection system and method
US6231513B1 (en) * 1998-10-14 2001-05-15 Daum Gmbh Contrast agent for ultrasonic imaging
WO2002078771A1 (en) * 2001-04-02 2002-10-10 Pentaferte Spa Injection needle for sclerotherapy
GB2396221A (en) * 2002-12-10 2004-06-16 Neorad As An extravasation detector which detects a difference in the fl-rate within a blood vessel
US7047058B1 (en) * 2001-02-06 2006-05-16 Medrad, Inc. Apparatuses, systems and methods for extravasation detection

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5271928A (en) * 1990-04-02 1993-12-21 Sintetica S.A. Stable microbubbles suspensions injectable into living organisms
US5733527A (en) * 1994-09-28 1998-03-31 Alliance Pharmaceutical Corp. Methods for harmonic imaging with ultrasound
WO1999027981A1 (en) * 1997-12-04 1999-06-10 Bracco Research S.A. Automatic liquid injection system and method
US6231513B1 (en) * 1998-10-14 2001-05-15 Daum Gmbh Contrast agent for ultrasonic imaging
US7047058B1 (en) * 2001-02-06 2006-05-16 Medrad, Inc. Apparatuses, systems and methods for extravasation detection
WO2002078771A1 (en) * 2001-04-02 2002-10-10 Pentaferte Spa Injection needle for sclerotherapy
GB2396221A (en) * 2002-12-10 2004-06-16 Neorad As An extravasation detector which detects a difference in the fl-rate within a blood vessel

Also Published As

Publication number Publication date
WO2009042621A2 (en) 2009-04-02

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