WO2009035307A3 - Novel compounds, process for preparing the same, and composition comprising the same for inhibiting pain - Google Patents

Novel compounds, process for preparing the same, and composition comprising the same for inhibiting pain Download PDF

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Publication number
WO2009035307A3
WO2009035307A3 PCT/KR2008/005439 KR2008005439W WO2009035307A3 WO 2009035307 A3 WO2009035307 A3 WO 2009035307A3 KR 2008005439 W KR2008005439 W KR 2008005439W WO 2009035307 A3 WO2009035307 A3 WO 2009035307A3
Authority
WO
WIPO (PCT)
Prior art keywords
same
preparing
novel compounds
composition
inhibiting pain
Prior art date
Application number
PCT/KR2008/005439
Other languages
French (fr)
Other versions
WO2009035307A2 (en
Inventor
Choo Hae-Young Park
Heung Sik Na
Hyewhon Rhim
Yoo Lim Kam
Seung Keun Back
Original Assignee
Univ Ewha Ind Collaboration
Choo Hae-Young Park
Heung Sik Na
Hyewhon Rhim
Yoo Lim Kam
Seung Keun Back
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Ewha Ind Collaboration, Choo Hae-Young Park, Heung Sik Na, Hyewhon Rhim, Yoo Lim Kam, Seung Keun Back filed Critical Univ Ewha Ind Collaboration
Publication of WO2009035307A2 publication Critical patent/WO2009035307A2/en
Publication of WO2009035307A3 publication Critical patent/WO2009035307A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms

Abstract

The present invention relates to novel compounds, a process for preparing the same, and a pain relief composition, comprising the same. The compound of the present invention has excellent inhibitory effect on T-type calcium channel activity, and chronic neuropathic and inflammatory pain, thereby being used to relieve pain.
PCT/KR2008/005439 2007-09-14 2008-09-12 Novel compounds, process for preparing the same, and composition comprising the same for inhibiting pain WO2009035307A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020070093694A KR101079459B1 (en) 2007-09-14 2007-09-14 Novel compounds, process for preparing the same, and composition comprising the same for inhibiting pain
KR10-2007-0093694 2007-09-14

Publications (2)

Publication Number Publication Date
WO2009035307A2 WO2009035307A2 (en) 2009-03-19
WO2009035307A3 true WO2009035307A3 (en) 2009-05-07

Family

ID=40452722

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2008/005439 WO2009035307A2 (en) 2007-09-14 2008-09-12 Novel compounds, process for preparing the same, and composition comprising the same for inhibiting pain

Country Status (2)

Country Link
KR (1) KR101079459B1 (en)
WO (1) WO2009035307A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101705718B1 (en) * 2013-12-30 2017-02-14 이화여자대학교 산학협력단 Novel amide derivatives or pharmaceutically acceptable salts thereof, preparation method thereof and pharmaceutical composition for prevention or treatment of pain containing the same as an active ingredient
MX2018004947A (en) 2015-10-22 2018-11-09 Cavion Inc Methods for treating angelman syndrome and related disorders.
US11130750B2 (en) 2017-02-15 2021-09-28 Cavion, Inc. Calcium channel inhibitors
JP7321097B2 (en) 2017-04-26 2023-08-04 カビオン・インコーポレイテッド Methods for Improving Memory and Cognition and Treating Memory and Cognitive Impairments
US20220016095A1 (en) 2018-10-03 2022-01-20 Cavion, Inc. Treating essential tremor using (r)-2-(4-isopropylphenyl)-n-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetamide
AU2020311942A1 (en) 2019-07-11 2022-02-24 Praxis Precision Medicines, Inc. Formulations of T-type calcium channel modulators and methods of use thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60214766A (en) * 1984-04-04 1985-10-28 Terumo Corp Amide derivative and 5-lipoxigenase inhibitor containing said derivative as active component
US4675319A (en) * 1985-06-20 1987-06-23 Recordati S. A. Chemical And Pharmaceutical Company Antianaphylactic and antibronchospastic piperazinyl-(N-substituted phenyl)carboxamides, compositions and use
US6420560B1 (en) * 1999-06-07 2002-07-16 Theravance, Inc. H1—histamine receptor antagonists

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60214766A (en) * 1984-04-04 1985-10-28 Terumo Corp Amide derivative and 5-lipoxigenase inhibitor containing said derivative as active component
US4675319A (en) * 1985-06-20 1987-06-23 Recordati S. A. Chemical And Pharmaceutical Company Antianaphylactic and antibronchospastic piperazinyl-(N-substituted phenyl)carboxamides, compositions and use
US6420560B1 (en) * 1999-06-07 2002-07-16 Theravance, Inc. H1—histamine receptor antagonists

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
YOO LIMKAM ET AL.: "Solution-phase combinatorial synthesis of nonpeptide bradykinin antagonists", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 12, 2004, pages 3543 - 3552 *

Also Published As

Publication number Publication date
KR101079459B1 (en) 2011-11-03
KR20090028239A (en) 2009-03-18
WO2009035307A2 (en) 2009-03-19

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