WO2009035070A1 - Transdermally absorbable preparation and transdermally absorbable system using the same - Google Patents

Transdermally absorbable preparation and transdermally absorbable system using the same Download PDF

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Publication number
WO2009035070A1
WO2009035070A1 PCT/JP2008/066516 JP2008066516W WO2009035070A1 WO 2009035070 A1 WO2009035070 A1 WO 2009035070A1 JP 2008066516 W JP2008066516 W JP 2008066516W WO 2009035070 A1 WO2009035070 A1 WO 2009035070A1
Authority
WO
WIPO (PCT)
Prior art keywords
transdermally absorbable
skin
preparation
enzyme
treating
Prior art date
Application number
PCT/JP2008/066516
Other languages
French (fr)
Japanese (ja)
Inventor
Fumio Kamiyama
Ying-Shu Quan
Original Assignee
Cosmed Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cosmed Pharmaceutical Co., Ltd. filed Critical Cosmed Pharmaceutical Co., Ltd.
Publication of WO2009035070A1 publication Critical patent/WO2009035070A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Disclosed are: a transdermally absorbable preparation which has excellent transdermal absorbability and low irritation to the skin, and which contains insulin that is highly safe and highly usable; and a transdermally absorbable system which comprises the preparation. Specifically disclosed are: a transdermally absorbable preparation characterized by comprising an aqueous insulin aspart solution having a pH value ranging from 7 to 8; a transdermally absorbable system characterized by pre-treating the skin with an enzyme and then applying the transdermally absorbable preparation to the skin; and a transdermally absorbable system characterized by pre-treating the skin with an enzyme, treating the skin with a substance capable of inactivating the enzyme, and then applying the transdermally absorbable preparation to the skin.
PCT/JP2008/066516 2007-09-12 2008-09-12 Transdermally absorbable preparation and transdermally absorbable system using the same WO2009035070A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007267203A JP2009067766A (en) 2007-09-12 2007-09-12 Percutaneous absorption promoting pharmaceutical preparation and percutaneous absorption system using the same
JP2007-267203 2007-09-12

Publications (1)

Publication Number Publication Date
WO2009035070A1 true WO2009035070A1 (en) 2009-03-19

Family

ID=40452076

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/066516 WO2009035070A1 (en) 2007-09-12 2008-09-12 Transdermally absorbable preparation and transdermally absorbable system using the same

Country Status (2)

Country Link
JP (1) JP2009067766A (en)
WO (1) WO2009035070A1 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03153634A (en) * 1989-11-09 1991-07-01 Shiseido Co Ltd Percutaneous absorption promoter and external preparation of skin
JPH06506444A (en) * 1991-01-22 1994-07-21 ノボ　ノルディスク　アクティーゼルスカブ Novel insulin analogs
JP2001522815A (en) * 1997-11-12 2001-11-20 アルザ コーポレイション Methods for reducing self-association of polypeptides
JP2005526126A (en) * 2002-05-07 2005-09-02 ノボ　ノルディスク　アクティーゼルスカブ Soluble preparation containing insulin aspart and insulin detemia

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03153634A (en) * 1989-11-09 1991-07-01 Shiseido Co Ltd Percutaneous absorption promoter and external preparation of skin
JPH06506444A (en) * 1991-01-22 1994-07-21 ノボ　ノルディスク　アクティーゼルスカブ Novel insulin analogs
JP2001522815A (en) * 1997-11-12 2001-11-20 アルザ コーポレイション Methods for reducing self-association of polypeptides
JP2005526126A (en) * 2002-05-07 2005-09-02 ノボ　ノルディスク　アクティーゼルスカブ Soluble preparation containing insulin aspart and insulin detemia

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KEIKO YANAGISAWA ET AL.: "Tonyobyo no Chiryo Senryaku Atarashii Insulin Chiryo-Saranaru Kairyo o Mezashite-", SAISHIN IGAKU, vol. 62, no. 4, 2007, pages 844 - 851 *
TAKUYA AWATA: "1-gata Tonyobyo no Shintenkai-Byogata Shindan Chiryo Insulin Analog Seizai wa 1-gata Tonyobyo no Chiryo o Do Kaetaka", PRACTICE, vol. 23, no. 4, 2006, pages 396 - 400 *

Also Published As

Publication number Publication date
JP2009067766A (en) 2009-04-02

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