WO2009033820A3 - Utilisation d'un peptide en tant qu'agent thérapeutique - Google Patents

Utilisation d'un peptide en tant qu'agent thérapeutique Download PDF

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Publication number
WO2009033820A3
WO2009033820A3 PCT/EP2008/008188 EP2008008188W WO2009033820A3 WO 2009033820 A3 WO2009033820 A3 WO 2009033820A3 EP 2008008188 W EP2008008188 W EP 2008008188W WO 2009033820 A3 WO2009033820 A3 WO 2009033820A3
Authority
WO
WIPO (PCT)
Prior art keywords
disease
combination
carbetocin
saralasin
aids
Prior art date
Application number
PCT/EP2008/008188
Other languages
English (en)
Other versions
WO2009033820A2 (fr
Inventor
Dorian Bevec
Fabio Cavalli
Vera Cavalli
Gerald Bacher
Original Assignee
Mondobiotech Laboratories Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mondobiotech Laboratories Ag filed Critical Mondobiotech Laboratories Ag
Publication of WO2009033820A2 publication Critical patent/WO2009033820A2/fr
Publication of WO2009033820A3 publication Critical patent/WO2009033820A3/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/556—Angiotensin converting enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/095—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biotechnology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne l'utilisation de la combinaison des composés peptidiques Sar-Arg-Val-Tyr-Val-His-Pro-Ala-OH et Butyryl-Tyr(Me)-lle-Gln-Asn- Cys-Pro-Leu-Gly-NH2 en tant que composés polythérapeutiques destinés à la prophylaxie et/ou au traitement du cancer, d'une maladie cardiaque et vasculaire, d'une maladie infectieuse, d'une maladie fibreuse, d'une maladie inflammatoire, d'une maladie neurodégénérative ou d'une maladie auto-immune.
PCT/EP2008/008188 2007-09-11 2008-09-09 Utilisation d'un peptide en tant qu'agent thérapeutique WO2009033820A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP07017745.6 2007-09-11
EP07017745 2007-09-11
EP07017755.5 2007-09-11
EP07017755 2007-09-11

Publications (2)

Publication Number Publication Date
WO2009033820A2 WO2009033820A2 (fr) 2009-03-19
WO2009033820A3 true WO2009033820A3 (fr) 2009-11-26

Family

ID=40452601

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/008188 WO2009033820A2 (fr) 2007-09-11 2008-09-09 Utilisation d'un peptide en tant qu'agent thérapeutique

Country Status (1)

Country Link
WO (1) WO2009033820A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11844764B2 (en) 2018-09-20 2023-12-19 Acadia Pharmaceuticals, Inc. Agitation process for preparing a carbetocin drug product

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3666258T3 (da) 2014-09-19 2024-02-05 Ferring Bv Fremgangsmåde til behandling af prader-willis syndrom
CA3112185A1 (fr) 2018-09-20 2020-03-26 Levo Therapeutics, Inc. Formulations intranasales stables de carbetocine
US20210346461A1 (en) * 2020-05-07 2021-11-11 John L. Couvaras Utilization of endogenous oubain-regulating compounds and compositions thereof in treatment of vascular disease

Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3932624A (en) * 1974-06-17 1976-01-13 Morton-Norwich Products, Inc. Method for prolonging the inhibitory effect of saralasin on angiotensin II
WO1994014462A1 (fr) * 1992-12-24 1994-07-07 Mackenzie Walser Procede de retardement de la progression d'une insuffisance renale chronique
WO1995030418A1 (fr) * 1994-05-09 1995-11-16 The Johns Hopkins University Procede permettant de ralentir la progression de l'infection a vih
US5629292A (en) * 1993-09-24 1997-05-13 The University Of Southern California Use of angiotensin III and analogs thereof in tissue repair
WO1998043661A1 (fr) * 1997-03-27 1998-10-08 Thomas Lundeberg Utilisation de substances ayant une activite d'oxytocine dans la preparation de medicaments pour la suberification d'une blessure
WO2001078758A1 (fr) * 2000-04-18 2001-10-25 Entretech Medical Ab Utilisation de substances a activite ocytocique contre les troubles climateriques
US6333313B1 (en) * 1998-10-29 2001-12-25 Board Of Regents, The University Of Texas System Clinical use of oxytocin alone or in combination to treat bone disorders
WO2003000692A2 (fr) * 2001-06-25 2003-01-03 Ferring Bv Agonistes de l'ocytocine
WO2003017922A2 (fr) * 2001-08-31 2003-03-06 Uvnaes-Moberg Kerstin Nouvelle utilisation
US20030113330A1 (en) * 1999-11-08 2003-06-19 Uhal Bruce D. Methods for treating pulmonary fibrosis
US20040176284A1 (en) * 2001-02-28 2004-09-09 Kerstin Uvnas-Moberg Use of oxytocin for the preparation of a pharmaceutical composition against cancer in situ and cervicitis
US20040235956A1 (en) * 2000-01-11 2004-11-25 Atossa Healthcare, Inc. Long-acting oxytocin analogues for the treatment and prevention of breast cancer and psychiatric disorders
US20060205636A1 (en) * 2002-06-21 2006-09-14 Jolanta Gutkowska Oxytocin as cardiomyogenesis inducer and uses thereof
WO2007013078A2 (fr) * 2005-07-27 2007-02-01 Mor Research Applications Ltd. Inhibition du systeme renine-angiotensine pour le traitement de pathologies renales, vasculaires et cartilagineuses
WO2007085087A1 (fr) * 2006-01-24 2007-08-02 The University Of British Columbia Polymorphismes de la voie de signalisation de la vasopressine en tant qu'indicateurs de l'évolution de l'état de sujets chez des sujets gravement atteints

Patent Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3932624A (en) * 1974-06-17 1976-01-13 Morton-Norwich Products, Inc. Method for prolonging the inhibitory effect of saralasin on angiotensin II
WO1994014462A1 (fr) * 1992-12-24 1994-07-07 Mackenzie Walser Procede de retardement de la progression d'une insuffisance renale chronique
US5629292A (en) * 1993-09-24 1997-05-13 The University Of Southern California Use of angiotensin III and analogs thereof in tissue repair
WO1995030418A1 (fr) * 1994-05-09 1995-11-16 The Johns Hopkins University Procede permettant de ralentir la progression de l'infection a vih
WO1998043661A1 (fr) * 1997-03-27 1998-10-08 Thomas Lundeberg Utilisation de substances ayant une activite d'oxytocine dans la preparation de medicaments pour la suberification d'une blessure
US6333313B1 (en) * 1998-10-29 2001-12-25 Board Of Regents, The University Of Texas System Clinical use of oxytocin alone or in combination to treat bone disorders
US20030113330A1 (en) * 1999-11-08 2003-06-19 Uhal Bruce D. Methods for treating pulmonary fibrosis
US20040235956A1 (en) * 2000-01-11 2004-11-25 Atossa Healthcare, Inc. Long-acting oxytocin analogues for the treatment and prevention of breast cancer and psychiatric disorders
WO2001078758A1 (fr) * 2000-04-18 2001-10-25 Entretech Medical Ab Utilisation de substances a activite ocytocique contre les troubles climateriques
US20040176284A1 (en) * 2001-02-28 2004-09-09 Kerstin Uvnas-Moberg Use of oxytocin for the preparation of a pharmaceutical composition against cancer in situ and cervicitis
WO2003000692A2 (fr) * 2001-06-25 2003-01-03 Ferring Bv Agonistes de l'ocytocine
WO2003017922A2 (fr) * 2001-08-31 2003-03-06 Uvnaes-Moberg Kerstin Nouvelle utilisation
US20060205636A1 (en) * 2002-06-21 2006-09-14 Jolanta Gutkowska Oxytocin as cardiomyogenesis inducer and uses thereof
WO2007013078A2 (fr) * 2005-07-27 2007-02-01 Mor Research Applications Ltd. Inhibition du systeme renine-angiotensine pour le traitement de pathologies renales, vasculaires et cartilagineuses
WO2007085087A1 (fr) * 2006-01-24 2007-08-02 The University Of British Columbia Polymorphismes de la voie de signalisation de la vasopressine en tant qu'indicateurs de l'évolution de l'état de sujets chez des sujets gravement atteints

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
AGER ELEANOR I ET AL: "The renin-angiotensin system and malignancy", CARCINOGENESIS (OXFORD), vol. 29, no. 9, 16 July 2008 (2008-07-16), pages 1675 - 1684, XP002541994, ISSN: 0143-3334 *
CAMARGO L A A ET AL: "Interaction between paraventricular nucleus and septal area in the control of physiological responses induced by angiotensin II.", BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, vol. 35, no. 9, September 2002 (2002-09-01), pages 1017 - 1023, XP002542706, ISSN: 0100-879X *
CEBALLOS A ET AL: "Oxytocin and prostaglandins F2alpha and E2 do not enhance HIV antigen production in vitro.", ARCHIVES OF VIROLOGY, vol. 148, no. 3, March 2003 (2003-03-01), pages 531 - 535, XP002542709, ISSN: 0304-8608 *
CHAO YEE ET AL: "Measurement of intravariceal pressure by fine needle direct puncture in hepatitis B surface antigen-positive cirrhotic patients: The effect of vasopressin", JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, vol. 8, no. 2, 1993, pages 157 - 160, XP002542708, ISSN: 0815-9319 *
DATABASE EMBASE [online] ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL; November 2003 (2003-11-01), WOO D S ET AL: "The Therapeutic Effect of Angiotensin II Receptor Antagonist in Idiopathic Pulmonary Fibrosis", XP002542009, Database accession no. EMB-2004055454 *
HEFFELFINGER S C: "The renin angiotensin system in the regulation of angiogenesis", CURRENT PHARMACEUTICAL DESIGN, vol. 13, no. 12, April 2007 (2007-04-01), pages 1215 - 1229, XP002541993, ISSN: 1381-6128 *
LEE F-Y ET AL: "HEMODYNAMIC EFFECTS OF A COMBINATION OF VASOPRESSIN AND KETANSERIN IN PATIENTS WITH HEPATITIS B-RELATED CIRRHOSIS", JOURNAL OF HEPATOLOGY, vol. 15, no. 1-2, 1992, pages 54 - 58, XP002542707, ISSN: 0168-8278 *
LI XIAOPENG ET AL: "Angiotensin converting enzyme-2 is protective but downregulated in human and experimental lung fibrosis", AMERICAN JOURNAL OF PHYSIOLOGY - LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, vol. 295, no. 1, 25 April 2008 (2008-04-25), pages L178 - L185, XP002541995, ISSN: 1040-0605 *
PLENDL J: "Angiogenesis and vascular regression in the ovary", ANATOMIA HISTOLOGIA EMBRYOLOGIA, vol. 29, no. 5, October 2000 (2000-10-01), pages 257 - 266, XP002542710, ISSN: 0340-2096 *
TUBERCULOSIS AND RESPIRATORY DISEASES 200311 KR, vol. 55, no. 5, November 2003 (2003-11-01), pages 478 - 487, ISSN: 0378-0066 *
UHAL BRUCE D ET AL: "Angiotensin-TGF-beta 1 crosstalk in human idiopathic pulmonary fibrosis: Autocrine mechanisms in myofibroblasts and macrophages", CURRENT PHARMACEUTICAL DESIGN, vol. 13, no. 12, April 2007 (2007-04-01), pages 1247 - 1256, XP009121584, ISSN: 1381-6128 *
WRIGHT J W ET AL: "Regulatory role of brain angiotensins in the control of physiological and behavioral responses", BRAIN RESEARCH REVIEWS, ELSEVIER, NL, vol. 17, no. 3, 1 September 1992 (1992-09-01), pages 227 - 262, XP024320102, ISSN: 0165-0173, [retrieved on 19920901] *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11844764B2 (en) 2018-09-20 2023-12-19 Acadia Pharmaceuticals, Inc. Agitation process for preparing a carbetocin drug product

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