WO2009033745A3 - Use of a peptide as a therapeutic agent - Google Patents
Use of a peptide as a therapeutic agent Download PDFInfo
- Publication number
- WO2009033745A3 WO2009033745A3 PCT/EP2008/007793 EP2008007793W WO2009033745A3 WO 2009033745 A3 WO2009033745 A3 WO 2009033745A3 EP 2008007793 W EP2008007793 W EP 2008007793W WO 2009033745 A3 WO2009033745 A3 WO 2009033745A3
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- WIPO (PCT)
- Prior art keywords
- glu
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- pro
- diseases
- val
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/085—Angiotensins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- A61K38/35—Corticotropin [ACTH]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P3/02—Nutrients, e.g. vitamins, minerals
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- A—HUMAN NECESSITIES
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- A61P31/04—Antibacterial agents
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- A61P31/20—Antivirals for DNA viruses
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
Abstract
The present invention is directed to the use of the peptide compound Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-OH as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the present invention relates to pharmaceutical compositions preferably in form of a lyophilisate or liquid buffer solution or artificial mother milk formulation or mother milk substitute containing the peptide Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-OH optionally together with at least one pharmaceutically acceptable carrier, cryoprotectant, lyoprotectant, excipient and/or diluent.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07017762 | 2007-09-11 | ||
EP07017762.1 | 2007-09-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009033745A2 WO2009033745A2 (en) | 2009-03-19 |
WO2009033745A3 true WO2009033745A3 (en) | 2009-05-07 |
Family
ID=40336638
Family Applications (11)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2008/007971 WO2009033787A2 (en) | 2007-09-11 | 2008-09-09 | Use of a peptide as a therapeutic agent |
PCT/EP2008/007793 WO2009033745A2 (en) | 2007-09-11 | 2008-09-09 | Use of a peptide as a therapeutic agent |
PCT/EP2008/007647 WO2009043467A1 (en) | 2007-09-11 | 2008-09-09 | U e of urocortin and corticotropin-releasing fact r as therapeutic agents |
PCT/EP2008/007601 WO2009040005A2 (en) | 2007-09-11 | 2008-09-09 | Use of the peptide rfmwmr as a therapeutic agent |
PCT/EP2008/007741 WO2009040032A2 (en) | 2007-09-11 | 2008-09-09 | Use of a peptide as a therapeutic agent |
PCT/EP2008/007811 WO2009040051A2 (en) | 2007-09-11 | 2008-09-09 | Use of the peptide rfmwmk alone or in combination with the peptide ymdgtmsqv as a therapeutic agent |
PCT/EP2008/007510 WO2009039968A2 (en) | 2007-09-11 | 2008-09-09 | Use of a peptide as a therapeutic agent |
PCT/EP2008/007943 WO2009040072A2 (en) | 2007-09-11 | 2008-09-09 | Use of a peptide as a therapeutic agent |
PCT/EP2008/007437 WO2009039957A2 (en) | 2007-09-11 | 2008-09-09 | Use of a peptide as a therapeutic agent |
PCT/EP2008/007944 WO2009040073A2 (en) | 2007-09-11 | 2008-09-09 | Use of a peptide as a therapeutic agent |
PCT/EP2008/007636 WO2009043456A2 (en) | 2007-09-11 | 2008-09-09 | Use of a peptide as a therapeutic agent |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2008/007971 WO2009033787A2 (en) | 2007-09-11 | 2008-09-09 | Use of a peptide as a therapeutic agent |
Family Applications After (9)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2008/007647 WO2009043467A1 (en) | 2007-09-11 | 2008-09-09 | U e of urocortin and corticotropin-releasing fact r as therapeutic agents |
PCT/EP2008/007601 WO2009040005A2 (en) | 2007-09-11 | 2008-09-09 | Use of the peptide rfmwmr as a therapeutic agent |
PCT/EP2008/007741 WO2009040032A2 (en) | 2007-09-11 | 2008-09-09 | Use of a peptide as a therapeutic agent |
PCT/EP2008/007811 WO2009040051A2 (en) | 2007-09-11 | 2008-09-09 | Use of the peptide rfmwmk alone or in combination with the peptide ymdgtmsqv as a therapeutic agent |
PCT/EP2008/007510 WO2009039968A2 (en) | 2007-09-11 | 2008-09-09 | Use of a peptide as a therapeutic agent |
PCT/EP2008/007943 WO2009040072A2 (en) | 2007-09-11 | 2008-09-09 | Use of a peptide as a therapeutic agent |
PCT/EP2008/007437 WO2009039957A2 (en) | 2007-09-11 | 2008-09-09 | Use of a peptide as a therapeutic agent |
PCT/EP2008/007944 WO2009040073A2 (en) | 2007-09-11 | 2008-09-09 | Use of a peptide as a therapeutic agent |
PCT/EP2008/007636 WO2009043456A2 (en) | 2007-09-11 | 2008-09-09 | Use of a peptide as a therapeutic agent |
Country Status (8)
Country | Link |
---|---|
US (4) | US20100210533A1 (en) |
EP (4) | EP2187940B1 (en) |
JP (4) | JP5385283B2 (en) |
KR (4) | KR20100057047A (en) |
AU (4) | AU2008303869A1 (en) |
CA (4) | CA2699109A1 (en) |
RU (4) | RU2010114006A (en) |
WO (11) | WO2009033787A2 (en) |
Families Citing this family (13)
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US9192522B2 (en) | 2003-05-02 | 2015-11-24 | Eveready Battery Company, Inc. | Tampon assembly having shaped pledget |
US8796416B1 (en) | 2010-10-25 | 2014-08-05 | Questcor Pharmaceuticals, Inc | ACTH prophylactic treatment of renal disorders |
DE102012004589A1 (en) * | 2012-03-09 | 2013-09-12 | Forschungszentrum Jülich GmbH | New angiotensin II-receptor agonist, useful for treating neurodegenerative diseases, preferably Alzheimer's dementia, Parkinson's disease, Huntington's disease and amyotrophic lateral sclerosis |
WO2014021942A1 (en) * | 2012-08-01 | 2014-02-06 | University Of Southern California | Methods for limiting development of neurodegeneration |
US20140294923A1 (en) * | 2013-02-20 | 2014-10-02 | Questcor Pharmaceuticals, Inc. | Acth for treatment of migraine headache |
WO2014153221A2 (en) * | 2013-03-14 | 2014-09-25 | Questcor Pharmaceuticals, Inc. | Acth for treatment of acute respiratory distress syndrome |
JP6480909B2 (en) | 2013-03-15 | 2019-03-13 | ユニバーシティー オブ サウザン カリフォルニア | Methods, compounds and compositions for the treatment of angiotensin related diseases |
US9623084B2 (en) | 2013-03-15 | 2017-04-18 | University Of Southern California | Methods for treating multiple sclerosis |
CN104277105B (en) * | 2013-07-12 | 2017-12-12 | 国家纳米科学中心 | Suppress amyloid beta aggregation and peptide inhibitor and its application of toxicity |
WO2016153558A1 (en) * | 2015-03-20 | 2016-09-29 | Atkinson Arthur J | Use of angiotensin ii (aii) receptor agonists to prevent or reduce hemodialysis-associated skeletal muscle cramps |
JP2019533661A (en) * | 2016-10-06 | 2019-11-21 | マトケ・ホールディングス・リミテッド | Antimicrobial composition |
WO2023044487A1 (en) * | 2021-09-17 | 2023-03-23 | Peptilogics, Inc. | Treatment of lung disease or injury using engineered antimicrobial peptides |
CN115521956B (en) * | 2022-10-21 | 2024-04-19 | 江苏诚信药业有限公司 | Method for synthesizing L-carnosine by biological enzyme catalysis |
Citations (1)
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US20040152769A1 (en) * | 2002-11-09 | 2004-08-05 | Ekwuribe Nnochiri Nkem | Modified carbamate-containing prodrugs and methods of synthesizing same |
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2008
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- 2008-09-09 US US12/677,303 patent/US20100210533A1/en not_active Abandoned
- 2008-09-09 AU AU2008303869A patent/AU2008303869A1/en not_active Abandoned
- 2008-09-09 WO PCT/EP2008/007971 patent/WO2009033787A2/en active Application Filing
- 2008-09-09 WO PCT/EP2008/007793 patent/WO2009033745A2/en active Application Filing
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- 2008-09-09 JP JP2010523394A patent/JP5385283B2/en not_active Expired - Fee Related
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- 2008-09-09 RU RU2010113998/15A patent/RU2010113998A/en not_active Application Discontinuation
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- 2008-09-09 US US12/676,932 patent/US20100197604A1/en not_active Abandoned
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