WO2009031045A3 - Anti-chikungunya monoclonal antibodies and uses thereof - Google Patents

Anti-chikungunya monoclonal antibodies and uses thereof Download PDF

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Publication number
WO2009031045A3
WO2009031045A3 PCT/IB2008/003092 IB2008003092W WO2009031045A3 WO 2009031045 A3 WO2009031045 A3 WO 2009031045A3 IB 2008003092 W IB2008003092 W IB 2008003092W WO 2009031045 A3 WO2009031045 A3 WO 2009031045A3
Authority
WO
WIPO (PCT)
Prior art keywords
chik
monoclonal antibodies
chikungunya
mabs
present
Prior art date
Application number
PCT/IB2008/003092
Other languages
French (fr)
Other versions
WO2009031045A2 (en
Inventor
Anne-Claire Brehin
Amadou Alpha Sall
Philippe Despres
Original Assignee
Pasteur Institut
Anne-Claire Brehin
Amadou Alpha Sall
Philippe Despres
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pasteur Institut, Anne-Claire Brehin, Amadou Alpha Sall, Philippe Despres filed Critical Pasteur Institut
Priority to JP2010523609A priority Critical patent/JP2010538291A/en
Priority to CA2698636A priority patent/CA2698636C/en
Priority to AU2008294415A priority patent/AU2008294415B2/en
Priority to CN200880114195.5A priority patent/CN102282171B/en
Priority to EP08828940.0A priority patent/EP2197912B1/en
Priority to ES08828940.0T priority patent/ES2550997T3/en
Priority to US12/676,780 priority patent/US8449887B2/en
Publication of WO2009031045A2 publication Critical patent/WO2009031045A2/en
Publication of WO2009031045A3 publication Critical patent/WO2009031045A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1081—Togaviridae, e.g. flavivirus, rubella virus, hog cholera virus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/18—Togaviridae; Flaviviridae
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/10—Detection of antigens from microorganism in sample from host
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention relates to the field of arbovirosis caused by Chikungunya virus (CHIK). The present invention specifically concerns anti-CHIK monoclonal antibodies (MAbs), and more specifically anti-CHIK.E2 MAbs and their use as diagnostic products in methods for detecting the presence or absence of a CHIK strain.
PCT/IB2008/003092 2007-09-07 2008-09-04 Anti-chikungunya monoclonal antibodies and uses thereof WO2009031045A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP2010523609A JP2010538291A (en) 2007-09-07 2008-09-04 Anti-chikungunya monoclonal antibody and use thereof
CA2698636A CA2698636C (en) 2007-09-07 2008-09-04 Anti-chikungunya monoclonal antibodies and uses thereof
AU2008294415A AU2008294415B2 (en) 2007-09-07 2008-09-04 Anti-chikungunya monoclonal antibodies and uses thereof
CN200880114195.5A CN102282171B (en) 2007-09-07 2008-09-04 Anti-Chikungunya virus monoclonal antibody and uses thereof
EP08828940.0A EP2197912B1 (en) 2007-09-07 2008-09-04 Anti-chikungunya monoclonal antibodies and uses thereof
ES08828940.0T ES2550997T3 (en) 2007-09-07 2008-09-04 Monoclonal anti-Chikungunya antibodies and their uses
US12/676,780 US8449887B2 (en) 2007-09-07 2008-09-04 Anti-chikungunya monoclonal antibodies and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA002598966A CA2598966A1 (en) 2007-09-07 2007-09-07 Anti-chikungunya monoclonal antibodies and uses thereof
CA2,598,966 2007-09-07

Publications (2)

Publication Number Publication Date
WO2009031045A2 WO2009031045A2 (en) 2009-03-12
WO2009031045A3 true WO2009031045A3 (en) 2009-04-23

Family

ID=40263023

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/003092 WO2009031045A2 (en) 2007-09-07 2008-09-04 Anti-chikungunya monoclonal antibodies and uses thereof

Country Status (8)

Country Link
US (1) US8449887B2 (en)
EP (1) EP2197912B1 (en)
JP (1) JP2010538291A (en)
CN (1) CN102282171B (en)
AU (1) AU2008294415B2 (en)
CA (3) CA2598966A1 (en)
ES (1) ES2550997T3 (en)
WO (1) WO2009031045A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010071610A1 (en) * 2008-12-19 2010-06-24 Agency For Science, Technology And Research (A*Star) Severe chikungunya biomarkers
EP2374816B1 (en) 2010-04-07 2016-09-28 Agency For Science, Technology And Research Binding molecules against Chikungunya virus and uses thereof
US9441032B2 (en) 2010-04-07 2016-09-13 Agency For Science, Technology And Research Binding molecules against Chikungunya virus and uses thereof
US20140050754A1 (en) * 2010-12-10 2014-02-20 National Healthcare Group Pte Ltd Immunogenic chikungunya virus peptides
CN102443051B (en) * 2011-09-30 2017-07-18 中国人民解放军广州军区疾病预防控制中心 A kind of recombinant antigen protein, kit and its application for detecting chikungunya virus
KR20150093834A (en) 2012-12-13 2015-08-18 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 Dna antibody constructs and method of using same
EP3021868A4 (en) * 2013-07-19 2017-03-01 Integral Molecular, Inc. Antibodies against chikungunya virus and uses thereof
SG11201604719WA (en) * 2013-12-13 2016-07-28 Univ Pennsylvania Dna antibody constructs and method of using same
AU2015355126B9 (en) 2014-12-01 2020-03-26 Inovio Pharmaceuticals, Inc. DNA antibody constructs and method of using same
MA41517A (en) * 2015-04-14 2017-12-19 Univ Vanderbilt NEUTRALIZATION OF THE ANTIBODY-MEDIATED CHIKUNGUNYA VIRUS
TW202300515A (en) 2016-10-20 2023-01-01 法商賽諾菲公司 Anti-chikv antibodies and uses thereof
JP7359390B2 (en) 2018-02-09 2023-10-11 国立大学法人大阪大学 Antibodies or antigen-binding fragments thereof against chikungunya virus and their uses
KR102016668B1 (en) * 2018-12-19 2019-08-30 주식회사 엠디헬스케어 DNA aptamer binding specifically to chikungunya virus envelope protein 2(CHIKV E2) and uses thereof
US11613746B2 (en) 2019-05-09 2023-03-28 The United States Of America As Represented By The Secretary Of The Army Methods for developing virus protein specific capture agents, capture agents, and methods of using the capture agents
KR102201261B1 (en) * 2019-05-15 2021-01-11 한국생명공학연구원 Monoclonal antibody specific to Chikungunya virus and uses thereof
US20230065377A1 (en) * 2019-08-31 2023-03-02 Vanderbilt University Human antibodies to alphaviruses
CN111398585B (en) * 2020-04-17 2023-03-24 中国人民解放军南部战区疾病预防控制中心 Immunodiagnosis kit for specifically detecting chikungunya virus NSP1 antigen
CN113248608B (en) * 2021-06-08 2023-06-27 中国人民解放军海军军医大学 Chikungunya virus E2 protein rabbit monoclonal antibody and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007105111A2 (en) * 2006-03-15 2007-09-20 Institut Pasteur Novel isolated and purified strains of chikungunya virus and polynucleotides and polypeptides sequences, diagnostic and immunogenical uses thereof
WO2008026225A2 (en) * 2006-09-01 2008-03-06 Bharat Biotech International Limited A vaccine for chikungunya virus infection

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007105111A2 (en) * 2006-03-15 2007-09-20 Institut Pasteur Novel isolated and purified strains of chikungunya virus and polynucleotides and polypeptides sequences, diagnostic and immunogenical uses thereof
WO2008026225A2 (en) * 2006-09-01 2008-03-06 Bharat Biotech International Limited A vaccine for chikungunya virus infection

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BLACKBURN N K ET AL: "Antigenic relationship between chikungunya virus strains and o'nyong nyong virus using monoclonal antibodies.", RESEARCH IN VIROLOGY 1995 JAN-FEB, vol. 146, no. 1, January 1995 (1995-01-01), pages 69 - 73, XP002512972, ISSN: 0923-2516 *
BRÉHIN ANNE-CLAIRE ET AL: "Production and characterization of mouse monoclonal antibodies reactive to Chikungunya envelope E2 glycoprotein.", VIROLOGY 5 FEB 2008, vol. 371, no. 1, 5 February 2008 (2008-02-05), pages 185 - 195, XP022417963, ISSN: 0042-6822 *
HUNDEKAR S L ET AL: "Development of monoclonal antibody based antigen capture ELISA to detect chikungunya virus antigen in mosquitoes.", THE INDIAN JOURNAL OF MEDICAL RESEARCH APR 2002, vol. 115, April 2002 (2002-04-01), pages 144 - 148, XP008101235, ISSN: 0971-5916 *

Also Published As

Publication number Publication date
CN102282171A (en) 2011-12-14
JP2010538291A (en) 2010-12-09
CA2698636A1 (en) 2009-03-12
US20110143333A1 (en) 2011-06-16
WO2009031045A2 (en) 2009-03-12
AU2008294415A1 (en) 2009-03-12
CA2639335A1 (en) 2009-03-07
AU2008294415B2 (en) 2014-09-04
EP2197912B1 (en) 2015-08-05
CA2598966A1 (en) 2009-03-07
EP2197912A2 (en) 2010-06-23
CN102282171B (en) 2016-02-17
ES2550997T3 (en) 2015-11-13
US8449887B2 (en) 2013-05-28
CA2698636C (en) 2015-11-24

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