WO2009027645A3 - Improvements in the preparation of a sample (e.g. involving dynamic nuclear polarisation) for analysis (e.g. by nmr or mri) - Google Patents

Improvements in the preparation of a sample (e.g. involving dynamic nuclear polarisation) for analysis (e.g. by nmr or mri) Download PDF

Info

Publication number
WO2009027645A3
WO2009027645A3 PCT/GB2008/002855 GB2008002855W WO2009027645A3 WO 2009027645 A3 WO2009027645 A3 WO 2009027645A3 GB 2008002855 W GB2008002855 W GB 2008002855W WO 2009027645 A3 WO2009027645 A3 WO 2009027645A3
Authority
WO
WIPO (PCT)
Prior art keywords
sample
analysis
preparation
station
mri
Prior art date
Application number
PCT/GB2008/002855
Other languages
French (fr)
Other versions
WO2009027645A2 (en
Inventor
Walter Friedrich Kockenberger
Graham Murray Smith
Robert Andrew Slade
Martin Charles Townsend
Daniel Robert Strange
Gary Stables
Original Assignee
Universtiy Of Nottingham
Univ St Andrews
Oxford Instr Molecular Biotool
Walter Friedrich Kockenberger
Graham Murray Smith
Robert Andrew Slade
Martin Charles Townsend
Daniel Robert Strange
Gary Stables
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0811685A external-priority patent/GB0811685D0/en
Application filed by Universtiy Of Nottingham, Univ St Andrews, Oxford Instr Molecular Biotool, Walter Friedrich Kockenberger, Graham Murray Smith, Robert Andrew Slade, Martin Charles Townsend, Daniel Robert Strange, Gary Stables filed Critical Universtiy Of Nottingham
Publication of WO2009027645A2 publication Critical patent/WO2009027645A2/en
Publication of WO2009027645A3 publication Critical patent/WO2009027645A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/282—Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/30—Sample handling arrangements, e.g. sample cells, spinning mechanisms
    • G01R33/307—Sample handling arrangements, e.g. sample cells, spinning mechanisms specially adapted for moving the sample relative to the MR system, e.g. spinning mechanisms, flow cells or means for positioning the sample inside a spectrometer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/60—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using electron paramagnetic resonance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/62—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using double resonance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/445—MR involving a non-standard magnetic field B0, e.g. of low magnitude as in the earth's magnetic field or in nanoTesla spectroscopy, comprising a polarizing magnetic field for pre-polarisation, B0 with a temporal variation of its magnitude or direction such as field cycling of B0 or rotation of the direction of B0, or spatially inhomogeneous B0 like in fringe-field MR or in stray-field imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/4808—Multimodal MR, e.g. MR combined with positron emission tomography [PET], MR combined with ultrasound or MR combined with computed tomography [CT]

Landscapes

  • Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

A method of preparation of a sample for analysis (such as a sample for dynamic unclear polarisation with subsequent analysis by NMR or MRI) comprises providing a sample (10) in a solid state at a first location (12); moving the sample (10) in the solid state to a second location (18); converting the sample (10) to a liquid state at. the second location (18); and performing an analysis on the sample (10) after conversion to the liquid state. Also according to the invention, sample preparation apparatus comprises: a sample preparation station (12) operable to prepare a sample (10) in a solid state; a conversion station (18) operable to convert a prepared sample (10) to a liquid state; a transport mechanism (19) operable to transport a sample (10) in a solid state from the sample preparation station (12) to the conversion station (18); and an analysis station (22) operable to perform an analysis on a sample (10) after conversion to the liquid state by the conversion station (18).
PCT/GB2008/002855 2007-08-24 2008-08-22 Improvements in the preparation of a sample (e.g. involving dynamic nuclear polarisation) for analysis (e.g. by nmr or mri) WO2009027645A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP07114986.8 2007-08-24
EP07114986 2007-08-24
GB0811685.7 2008-06-26
GB0811685A GB0811685D0 (en) 2008-06-26 2008-06-26 Improvements in or relating to methods and apparatus for preparation of a sample for analysis

Publications (2)

Publication Number Publication Date
WO2009027645A2 WO2009027645A2 (en) 2009-03-05
WO2009027645A3 true WO2009027645A3 (en) 2009-04-23

Family

ID=39957536

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2008/002855 WO2009027645A2 (en) 2007-08-24 2008-08-22 Improvements in the preparation of a sample (e.g. involving dynamic nuclear polarisation) for analysis (e.g. by nmr or mri)

Country Status (1)

Country Link
WO (1) WO2009027645A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8731640B2 (en) 2007-03-28 2014-05-20 General Electric Company Fluid path system for dissolution and transport of a hyperpolarized material
WO2010061191A1 (en) * 2008-11-27 2010-06-03 Oxford Instruments Molecular Biotools Limited Apparatus for dynamic nuclear polarisation

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5617859A (en) * 1995-10-02 1997-04-08 General Electric Company Apparatus and methods for magnetic resonance (MR) imaging of cavities using fluids polarized at low temperatures
WO2002036005A1 (en) * 2000-11-03 2002-05-10 Amersham Health As Methods and devices for polarised nmr samples
WO2002037132A1 (en) * 2000-11-03 2002-05-10 Amersham Health As Methods and devices for dissolving hyperpolarised solid material for nmr analyses
WO2005114244A1 (en) * 2004-05-18 2005-12-01 Oxford Instruments Superconductivity Limited Apparatus and method for performing in-vitro dnp-nmr measurements
WO2006077361A2 (en) * 2005-01-21 2006-07-27 Oxford Instruments Molecular Biotools Limited Method of carrying out dynamic nuclear polarization
WO2007007022A1 (en) * 2005-07-12 2007-01-18 Oxford Instruments Molecular Biotools Limited Magnet assembly for dnp and/or nmr applications

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5617859A (en) * 1995-10-02 1997-04-08 General Electric Company Apparatus and methods for magnetic resonance (MR) imaging of cavities using fluids polarized at low temperatures
WO2002036005A1 (en) * 2000-11-03 2002-05-10 Amersham Health As Methods and devices for polarised nmr samples
WO2002037132A1 (en) * 2000-11-03 2002-05-10 Amersham Health As Methods and devices for dissolving hyperpolarised solid material for nmr analyses
WO2005114244A1 (en) * 2004-05-18 2005-12-01 Oxford Instruments Superconductivity Limited Apparatus and method for performing in-vitro dnp-nmr measurements
WO2006077361A2 (en) * 2005-01-21 2006-07-27 Oxford Instruments Molecular Biotools Limited Method of carrying out dynamic nuclear polarization
WO2007007022A1 (en) * 2005-07-12 2007-01-18 Oxford Instruments Molecular Biotools Limited Magnet assembly for dnp and/or nmr applications

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ARDENKJAER-LARSEN J H ET AL: "Increase in signal-to-noise ratio of >10,000 times in liquid-state NMR", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC.; US, vol. 100, no. 18, 2 September 2003 (2003-09-02), pages 10158 - 10163, XP002280244, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
WO2009027645A2 (en) 2009-03-05

Similar Documents

Publication Publication Date Title
WO2005072780A3 (en) Cellular labeling for nuclear magnetic resonance techniques
WO2007065012A3 (en) Apparatus and method for adjusting an orientation of probes
HK1129340A1 (en) Vials and apparatus for obtaining an aliquot of a sample
WO2009016548A3 (en) Method and system for imaging samples
SG138529A1 (en) A method and unit for preparing a sample for the microbiological analysis of a liquid
MY185753A (en) Coding apparatus and decoding apparatus with bandwidth extension
WO2009009786A3 (en) Magneto-motive ultrasound detection of magnetic nanoparticles
TW201144850A (en) Method and system for mobile device based GNSS position computation without ephemeris data
WO2010112039A8 (en) Magnetic resonance imaging with improved imaging contrast
WO2009124206A3 (en) Generic positioning protocol
WO2008008150A3 (en) Methods and apparatus for enhanced performance in a multi-pass video encoder
EP2169379A3 (en) Sample imaging apparatus
TW200634850A (en) Working device and working method
WO2009009105A3 (en) Compositions and methods for producing cellular labels for nuclear magnetic resonance techniques
WO2011006913A8 (en) Optimized lancet strip
WO2007098430A3 (en) Sampling a device bus
EP2442557A3 (en) Radiation imaging apparatus, control method for radiation imaging apparatus, and storage medium
WO2009024669A3 (en) Device for providing a high energy x-ray beam
WO2010014850A3 (en) Apparatus and method including a direct bombardment detector and a secondary detector for use in electron microscopy
WO2009136394A3 (en) Apparatus and method for handling weight data related to transportation
EP2706749A3 (en) 3D Video conversion system and method, key frame selection method, key frame selection method and apparatus thereof
WO2009027645A3 (en) Improvements in the preparation of a sample (e.g. involving dynamic nuclear polarisation) for analysis (e.g. by nmr or mri)
WO2010017524A3 (en) System, method and computer accessible medium for providing real-time diffusional kurtosis imaging
WO2012158000A3 (en) Method for measuring the concentration of an atmospheric or water pollutant
TW200705117A (en) Measuring apparatus, exposure apparatus, and device manufacturing method

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08788415

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08788415

Country of ref document: EP

Kind code of ref document: A2