WO2009027478A3 - A method of removing preservatives from a liquid pharmaceutical preparation - Google Patents

A method of removing preservatives from a liquid pharmaceutical preparation Download PDF

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Publication number
WO2009027478A3
WO2009027478A3 PCT/EP2008/061318 EP2008061318W WO2009027478A3 WO 2009027478 A3 WO2009027478 A3 WO 2009027478A3 EP 2008061318 W EP2008061318 W EP 2008061318W WO 2009027478 A3 WO2009027478 A3 WO 2009027478A3
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutical preparation
liquid pharmaceutical
preservative
particulate material
removing preservatives
Prior art date
Application number
PCT/EP2008/061318
Other languages
French (fr)
Other versions
WO2009027478A2 (en
Inventor
Christian Rischel
Original Assignee
Novo Nordisk Healthcare Ag
Christian Rischel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk Healthcare Ag, Christian Rischel filed Critical Novo Nordisk Healthcare Ag
Publication of WO2009027478A2 publication Critical patent/WO2009027478A2/en
Publication of WO2009027478A3 publication Critical patent/WO2009027478A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21021—Coagulation factor VIIa (3.4.21.21)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention relates to a method for removing a preservative from a liquid pharmaceutical preparation, said method comprising the steps of: (a) providing a sealed container comprising an initial liquid pharmaceutical preparation comprising (i) a protein belonging to the group of serine proteases/Vitamin K-dependent proteins and (ii) a preservative; (b) contacting said pharmaceutical preparation with a particulate material with particle surfaces consisting mainly of carbon, capable of retaining at least a substantial portion of said preservative; and (c) separating said liquid pharmaceutical preparation from said particulate material so as to obtain a resulting liquid pharmaceutical preparation having a reduced concentration of said preservative compared to the initial liquid pharmaceutical preparation.
PCT/EP2008/061318 2007-08-29 2008-08-28 A method of removing preservatives from a liquid pharmaceutical preparation WO2009027478A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07115250 2007-08-29
EP07115250.8 2007-08-29

Publications (2)

Publication Number Publication Date
WO2009027478A2 WO2009027478A2 (en) 2009-03-05
WO2009027478A3 true WO2009027478A3 (en) 2009-04-30

Family

ID=38969446

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/061318 WO2009027478A2 (en) 2007-08-29 2008-08-28 A method of removing preservatives from a liquid pharmaceutical preparation

Country Status (1)

Country Link
WO (1) WO2009027478A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR089313A1 (en) * 2011-12-19 2014-08-13 Colgate Palmolive Co ORAL RINSE PRODUCT
CA3018985C (en) 2016-04-22 2021-11-16 Eli Lilly And Company Infusion site passivating device for extended wear during continuous subcutaneous insulin infusion (csii)
EP3618890A1 (en) * 2017-05-01 2020-03-11 Becton, Dickinson and Company Filter for reducing phenolic compounds from insulin and related infusion and injection devices

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994000213A1 (en) * 1992-06-26 1994-01-06 Tektolit Ab Method for purifying hydrophobic proteins and peptides by means of hydrophobic zeolites
WO1997015391A1 (en) * 1995-10-24 1997-05-01 Sten Andersson Use of hydrophobic zeolites, syringe and method for removing of preservatives from a polypeptide solution
WO2004082708A2 (en) * 2003-03-18 2004-09-30 Novo Nordisk Health Care Ag Liquid, aqueous, pharmaceutical compositions of factor vii polypeptides

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994000213A1 (en) * 1992-06-26 1994-01-06 Tektolit Ab Method for purifying hydrophobic proteins and peptides by means of hydrophobic zeolites
WO1997015391A1 (en) * 1995-10-24 1997-05-01 Sten Andersson Use of hydrophobic zeolites, syringe and method for removing of preservatives from a polypeptide solution
WO2004082708A2 (en) * 2003-03-18 2004-09-30 Novo Nordisk Health Care Ag Liquid, aqueous, pharmaceutical compositions of factor vii polypeptides

Also Published As

Publication number Publication date
WO2009027478A2 (en) 2009-03-05

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