WO2009025983A3 - Method for preparing 5-haloalkyl-4,5-dihydroisoxazole derivatives - Google Patents
Method for preparing 5-haloalkyl-4,5-dihydroisoxazole derivatives Download PDFInfo
- Publication number
- WO2009025983A3 WO2009025983A3 PCT/US2008/072074 US2008072074W WO2009025983A3 WO 2009025983 A3 WO2009025983 A3 WO 2009025983A3 US 2008072074 W US2008072074 W US 2008072074W WO 2009025983 A3 WO2009025983 A3 WO 2009025983A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- preparing
- haloalkyl
- dihydroisoxazole derivatives
- dihydroisoxazole
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
- C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
- C07C49/83—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
- C07C49/835—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups having unsaturation outside an aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
- C07C65/38—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups having unsaturation outside the aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/007—Esters of unsaturated alcohols having the esterified hydroxy group bound to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Priority Applications (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES08797091.9T ES2587386T3 (en) | 2007-08-17 | 2008-08-04 | Method for the preparation of 5-haloalkyl-4,5-dihydroisoxazole derivatives |
BRPI0814153A BRPI0814153B8 (en) | 2007-08-17 | 2008-08-04 | METHOD FOR PREPARING 5-HALOALKYL-4,5-DIHYDROISOXAZOLE DERIVATIVES AND STARTING COMPOUNDS USEFUL IN THE METHOD |
EP08797091.9A EP2176244B1 (en) | 2007-08-17 | 2008-08-04 | Method for preparing 5-haloalkyl-4,5-dihydroisoxazole derivatives |
KR1020157017534A KR20150082693A (en) | 2007-08-17 | 2008-08-04 | Method for preparing 5-haloalkyl-4,5-dihydroisoxazole derivatives |
JP2010521081A JP5965102B2 (en) | 2007-08-17 | 2008-08-04 | Process for preparing 5-haloalkyl-4,5-dihydroisoxazole derivatives |
MX2013011829A MX337588B (en) | 2007-08-17 | 2008-08-04 | Method for preparing 5-haloalkyl-4,5-dihydroisoxazole derivatives. |
RU2010109881/04A RU2536039C2 (en) | 2007-08-17 | 2008-08-04 | Method of obtaining 5- halogenalkyl-4,5-dihydroisoxazole derivatives |
MX2010001773A MX2010001773A (en) | 2007-08-17 | 2008-08-04 | Method for preparing 5-haloalkyl-4,5-dihydroisoxazole derivatives. |
AU2008289321A AU2008289321B2 (en) | 2007-08-17 | 2008-08-04 | Method for preparing 5-haloalkyl-4,5-dihydroisoxazole derivatives |
CA2693067A CA2693067C (en) | 2007-08-17 | 2008-08-04 | Method for preparing 5-haloalkyl-4,5-dihydroisoxazole derivatives |
US12/679,382 US8217180B2 (en) | 2007-08-17 | 2008-08-04 | Method for preparing 5-haloalkyl-4,5-dihydroisoxazole derivatives |
CN200880103362A CN101855215A (en) | 2007-08-17 | 2008-08-04 | Process for the preparation of 5-haloalkyl-4, 5-dihydroisoxazole derivatives |
IL203174A IL203174A (en) | 2007-08-17 | 2010-01-06 | Naphthalenecarnoxylate and phenylcarnoxylate derivatives and a method for preparing the derivatives |
ZA2010/00214A ZA201000214B (en) | 2007-08-17 | 2010-01-12 | Method for preparing 5-haloalkyl-4,5-dihydroisoxazole derivatives |
HK10109984.7A HK1143373A1 (en) | 2007-08-17 | 2010-10-21 | Method for preparing 5-haloalkyl-4,5-dihydroisoxazole derivatives 5--45- |
US13/544,113 US8513431B2 (en) | 2007-08-17 | 2012-07-09 | Method for preparing 5-haloalkyl-4, 5-dihydroisoxazole derivatives |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US96511507P | 2007-08-17 | 2007-08-17 | |
US60/965,115 | 2007-08-17 | ||
US4345908P | 2008-04-09 | 2008-04-09 | |
US61/043,459 | 2008-04-09 | ||
US8045408P | 2008-07-14 | 2008-07-14 | |
US61/080,454 | 2008-07-14 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/679,382 A-371-Of-International US8217180B2 (en) | 2007-08-17 | 2008-08-04 | Method for preparing 5-haloalkyl-4,5-dihydroisoxazole derivatives |
US13/544,113 Division US8513431B2 (en) | 2007-08-17 | 2012-07-09 | Method for preparing 5-haloalkyl-4, 5-dihydroisoxazole derivatives |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2009025983A2 WO2009025983A2 (en) | 2009-02-26 |
WO2009025983A3 true WO2009025983A3 (en) | 2009-05-07 |
WO2009025983A4 WO2009025983A4 (en) | 2009-06-25 |
Family
ID=40350174
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2008/072074 WO2009025983A2 (en) | 2007-08-17 | 2008-08-04 | Method for preparing 5-haloalkyl-4,5-dihydroisoxazole derivatives |
Country Status (20)
Country | Link |
---|---|
US (2) | US8217180B2 (en) |
EP (1) | EP2176244B1 (en) |
JP (2) | JP5965102B2 (en) |
KR (2) | KR20150082693A (en) |
CN (2) | CN105693646A (en) |
AR (1) | AR067948A1 (en) |
AU (1) | AU2008289321B2 (en) |
BR (1) | BRPI0814153B8 (en) |
CA (1) | CA2693067C (en) |
CO (1) | CO6260136A2 (en) |
ES (1) | ES2587386T3 (en) |
HK (1) | HK1143373A1 (en) |
IL (1) | IL203174A (en) |
MX (2) | MX337588B (en) |
MY (2) | MY176115A (en) |
PT (1) | PT2176244T (en) |
RU (1) | RU2536039C2 (en) |
TW (3) | TWI600639B (en) |
WO (1) | WO2009025983A2 (en) |
ZA (1) | ZA201000214B (en) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2558848C (en) | 2004-03-05 | 2013-11-19 | Nissan Chemical Industries, Ltd. | Isoxazoline-substituted benzamide compound and pesticide |
TW200803740A (en) | 2005-12-16 | 2008-01-16 | Du Pont | 5-aryl isoxazolines for controlling invertebrate pests |
TWI412322B (en) | 2005-12-30 | 2013-10-21 | Du Pont | Isoxazolines for controlling invertebrate pests |
MX2009013469A (en) * | 2007-06-13 | 2010-01-20 | Du Pont | Isoxazoline insecticides. |
TWI430995B (en) | 2007-06-26 | 2014-03-21 | Du Pont | Naphthalene isoxazoline invertebrate pest control agents |
JP5349303B2 (en) | 2007-06-27 | 2013-11-20 | 日産化学工業株式会社 | Method for producing 3-hydroxypropan-1-one compound, 2-propen-1-one compound and isoxazoline compound |
EP2957284B1 (en) | 2007-06-27 | 2018-01-17 | E. I. du Pont de Nemours and Company | Animal pest control method |
TWI600639B (en) * | 2007-08-17 | 2017-10-01 | 杜邦股份有限公司 | Compound for preparing 5-haloalkyl-4,5-dihydroisoxazole derivatives |
WO2009045999A1 (en) | 2007-10-03 | 2009-04-09 | E. I. Du Pont De Nemours And Company | Naphthalene isoxazoline compounds for control of invertebrate pests |
TWI518076B (en) | 2008-04-09 | 2016-01-21 | 杜邦股份有限公司 | Method for preparing heterocyclic compound |
EP2306837B2 (en) | 2008-07-09 | 2023-10-25 | Basf Se | Pesticidal active mixtures comprising isoxazoline compounds i |
WO2010003877A1 (en) | 2008-07-09 | 2010-01-14 | Basf Se | Pesticidal mixtures comprising isoxazoline compounds ii |
AU2009284229A1 (en) | 2008-08-22 | 2010-02-25 | Syngenta Limited | Insceticidal compounds |
WO2010020522A1 (en) | 2008-08-22 | 2010-02-25 | Syngenta Participations Ag | Insecticidal compounds |
MX2011002072A (en) | 2008-09-04 | 2011-03-29 | Syngenta Participations Ag | Insecticidal compounds. |
CA2747986A1 (en) | 2008-12-23 | 2010-07-01 | Basf Se | Substituted amidine compounds for combating animal pests |
WO2010072781A2 (en) | 2008-12-23 | 2010-07-01 | Basf Se | Imine compounds for combating invertebrate pests |
JP2012522750A (en) * | 2009-04-01 | 2012-09-27 | ビーエーエスエフ ソシエタス・ヨーロピア | Isoxazoline compounds for combating invertebrate pests |
MX2020001453A (en) | 2009-12-17 | 2021-07-29 | Merial Ltd | Anti parasitic dihydroazole compounds and compositions comprising same. |
US8999889B2 (en) | 2010-02-01 | 2015-04-07 | Basf Se | Substituted ketonic isoxazoline compounds and derivatives for combating animal pests |
MD4363C1 (en) * | 2010-05-27 | 2016-03-31 | E.I. Du Pont De Nemours And Company | Crystalline form of 4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide and uses thereof |
UY33403A (en) | 2010-06-17 | 2011-12-30 | Novartis Ag | ORGANIC COMPOUNDS WITH NEW ISOXAZOLINES, THEIR N-OXIDES, S-OXIDES AND SALTS |
WO2012038851A1 (en) | 2010-09-24 | 2012-03-29 | Pfizer Inc. | Isoxazoline oximes as antiparasitic agents |
LT2621894T (en) | 2010-09-27 | 2017-01-25 | E. I. Du Pont De Nemours And Company | Method for preparing 2-amino-n-(2,2,2-trifluoroethyl) acetamide |
CA2826067A1 (en) | 2011-02-10 | 2012-08-16 | Novartis Ag | Isoxazoline derivatives for controlling invertebrate pests |
CN103502246A (en) | 2011-03-10 | 2014-01-08 | 诺瓦提斯公司 | Isoxazole derivatives |
JP6075563B2 (en) | 2011-11-08 | 2017-02-08 | 日産化学工業株式会社 | Catalytic asymmetric synthesis method of optically active isoxazoline compound and optically active isoxazoline compound |
CA2858766A1 (en) | 2011-12-23 | 2013-06-27 | Basf Se | Isothiazoline compounds for combating invertebrate pests |
LT2922845T (en) | 2012-11-20 | 2018-09-10 | Merial, Inc. | Anthelmintic compounds and compositions and method of using thereof |
PT3063144T (en) | 2013-11-01 | 2021-10-28 | Boehringer Ingelheim Animal Health Usa Inc | Antiparisitic and pesticidal isoxazoline compounds |
NZ726874A (en) | 2014-05-19 | 2018-03-23 | Merial Inc | Anthelmintic compounds |
US10864193B2 (en) | 2014-10-31 | 2020-12-15 | Boehringer Ingelheim Animal Health USA Inc. | Parasiticidal compositions comprising fipronil at high concentrations |
UY37137A (en) | 2016-02-24 | 2017-09-29 | Merial Inc | ANTIPARASITARY COMPOUNDS OF ISOXAZOLINE, INJECTABLE FORMULATIONS OF PROLONGED ACTION THAT INCLUDE THEM, METHODS AND USES OF THE SAME |
CN109195955B (en) | 2016-04-06 | 2022-10-18 | 勃林格殷格翰动物保健美国公司 | Process for the preparation of crystalline toluene solvates of enantiomerically enriched isoxazoline compound- (S) -afoxolaner |
MX2019004266A (en) | 2016-10-14 | 2019-09-04 | Boehringer Ingelheim Animal Health Usa Inc | Pesticidal and parasiticidal vinyl isoxazoline compounds. |
UY37665A (en) * | 2017-04-05 | 2018-10-31 | Merial Inc | CRYSTAL FORMS OF (S) -AFOXOLANER |
JP2020530850A (en) | 2017-08-14 | 2020-10-29 | ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド | Pesticides and parasites Pyrazole-isoxazoline compounds |
MX2020008404A (en) | 2018-02-13 | 2020-09-25 | Gilead Sciences Inc | Pd-1/pd-l1 inhibitors. |
CA3093130C (en) | 2018-04-19 | 2023-10-17 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
EP3789382B1 (en) * | 2018-04-27 | 2023-07-05 | Kumiai Chemical Industry Co., Ltd. | Production method for 5,5-di-substituted-4,5-dihydroisoxazole |
AU2019301811B2 (en) | 2018-07-13 | 2022-05-26 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
JP7158577B2 (en) | 2018-10-24 | 2022-10-21 | ギリアード サイエンシーズ, インコーポレイテッド | PD-1/PD-L1 inhibitor |
CA3177546A1 (en) | 2020-05-27 | 2021-12-02 | Axial Therapeutics, Inc. | Tlr2 modulator compounds, pharmaceutical compositions and uses thereof |
JP2023553343A (en) | 2020-11-25 | 2023-12-21 | アカゲラ・メディスンズ,インコーポレイテッド | Lipid nanoparticles and related methods of use for delivering nucleic acids |
WO2023012821A1 (en) * | 2021-08-01 | 2023-02-09 | Zenfold Sustainable Technologies Private Limited | A process for the preparation of carbamoyl benzamide phenyl isoxazoline class drug/s and its intermediates |
CN115710185B (en) * | 2021-08-23 | 2024-05-03 | 中国石油化工股份有限公司 | Method for producing methylamine using metal carbide catalyst |
CN116253658B (en) * | 2022-11-25 | 2023-08-11 | 济南久隆医药科技有限公司 | Synthesis method of aforana intermediate |
CN115772091B (en) * | 2023-01-05 | 2023-06-23 | 济南久隆医药科技有限公司 | Synthesis method of 2-amino-N- (2, 2-trifluoroethyl) acetamide |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009001942A1 (en) * | 2007-06-27 | 2008-12-31 | Nissan Chemical Industries, Ltd. | Method for production of 3-hydroxypropan-1-one compound, method for production of 2-propen-1-one compound, and method for production of isoxazoline compound |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3879532A (en) | 1974-01-18 | 1975-04-22 | Shell Oil Co | Control by isoxazoles of endoparasitic nematodes |
US4129568A (en) | 1977-05-12 | 1978-12-12 | Monsanto Company | 2-[3-Aryl-2-isoxazolin-5-yl]benzoates |
US5849736A (en) | 1993-11-24 | 1998-12-15 | The Dupont Merck Pharmaceutical Company | Isoxazoline and isoxazole fibrinogen receptor antagonists |
GB9505651D0 (en) | 1995-03-21 | 1995-05-10 | Agrevo Uk Ltd | AgrEvo UK Limited |
CN1076351C (en) | 1996-04-26 | 2001-12-19 | 日本曹达株式会社 | Novel benzene derivatives substituted by heterocycles and herbicides |
AU726670B2 (en) | 1996-06-06 | 2000-11-16 | Dow Agrosciences Llc | Benzyloxy substituted aromatics and their use as fungicides and insecticides |
GB2351081A (en) | 1999-06-18 | 2000-12-20 | Lilly Forschung Gmbh | Pharmaceutically active imidazoline compounds and analogues thereof |
DE10114597A1 (en) | 2001-03-23 | 2002-10-02 | Bayer Cropscience Gmbh | Arylisoxazoline derivatives, process for their preparation and their use as pesticides |
EP1538138A4 (en) | 2002-08-26 | 2007-07-25 | Nissan Chemical Ind Ltd | Substituted benzanilide compound and pest control agent |
DE10320782A1 (en) | 2003-05-09 | 2004-11-25 | Bayer Cropscience Ag | Substituted oxyarenes |
JP2005272452A (en) | 2004-02-23 | 2005-10-06 | Nissan Chem Ind Ltd | Substituted benzanilide compound and pesticide |
CA2558848C (en) | 2004-03-05 | 2013-11-19 | Nissan Chemical Industries, Ltd. | Isoxazoline-substituted benzamide compound and pesticide |
JP2007530598A (en) | 2004-03-26 | 2007-11-01 | サイトカイン・ファーマサイエンシズ・インコーポレーテッド | COMPOUND, COMPOSITION, MAKING PROCESS AND METHOD OF USE FOR INHIBITION OF MACROPHAGE MIGRATION INHIBITOR |
JP5051340B2 (en) * | 2005-06-06 | 2012-10-17 | 日産化学工業株式会社 | Substituted isoxazoline compounds and pest control agents |
MY146795A (en) | 2005-06-09 | 2012-09-28 | Novartis Ag | Process for the synthesis of organic compounds |
GB0514071D0 (en) | 2005-07-07 | 2005-08-17 | Zealand Pharma As | N- or C- terminally modified small peptides |
KR100546831B1 (en) | 2005-08-31 | 2006-01-25 | (주) 마이크로프랜드 | Method for fabricating probe needle tip of probe card |
EP1932836B1 (en) | 2005-09-02 | 2013-11-06 | Nissan Chemical Industries, Ltd. | Isoxazoline-substituted benzamide compound and harmful organism-controlling agent |
JP2007106756A (en) | 2005-09-14 | 2007-04-26 | Nissan Chem Ind Ltd | Substituted isoxazoline compound and pesticide |
TWI266597B (en) * | 2005-09-27 | 2006-11-11 | Delta Electronics Inc | Electronic apparatus capable of dissipating heat uniformly |
JP2009519937A (en) * | 2005-12-14 | 2009-05-21 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | Isoxazolines for invertebrate pest control |
TW200803740A (en) | 2005-12-16 | 2008-01-16 | Du Pont | 5-aryl isoxazolines for controlling invertebrate pests |
US7700808B2 (en) | 2005-12-26 | 2010-04-20 | Nissan Chemical Industries, Ltd. | 1-3-bis(substituted phenyl)-3-hydroxypropan-1-one or 2-propen-1-one compound, and salt thereof |
TWI412322B (en) | 2005-12-30 | 2013-10-21 | Du Pont | Isoxazolines for controlling invertebrate pests |
ES2344027T3 (en) | 2006-03-10 | 2010-08-16 | Nissan Chemical Industries, Ltd. | ISOXAZOLINE COMPOSITE REPLACED AND PEST CONTROL AGENT. |
AU2007240954A1 (en) | 2006-04-20 | 2007-11-01 | E. I. Du Pont De Nemours And Company | Pyrazolines for controlling invertebrate pests |
WO2007125984A1 (en) | 2006-04-28 | 2007-11-08 | Nihon Nohyaku Co., Ltd. | Isoxazoline derivative, pest-controlling agent, and use of the pest-controlling agent |
JP2008044880A (en) | 2006-08-15 | 2008-02-28 | Bayer Cropscience Ag | Insecticidal isooxazolines |
EP2151437A4 (en) | 2007-03-07 | 2012-05-02 | Nissan Chemical Ind Ltd | Isoxazoline-substituted benzamide compound and pest control agent |
WO2008122375A2 (en) * | 2007-04-10 | 2008-10-16 | Bayer Cropscience Ag | Insecticidal aryl isoxazoline derivatives |
MX2009013469A (en) | 2007-06-13 | 2010-01-20 | Du Pont | Isoxazoline insecticides. |
TWI430995B (en) | 2007-06-26 | 2014-03-21 | Du Pont | Naphthalene isoxazoline invertebrate pest control agents |
EP2957284B1 (en) | 2007-06-27 | 2018-01-17 | E. I. du Pont de Nemours and Company | Animal pest control method |
TWI600639B (en) | 2007-08-17 | 2017-10-01 | 杜邦股份有限公司 | Compound for preparing 5-haloalkyl-4,5-dihydroisoxazole derivatives |
TWI556741B (en) | 2007-08-17 | 2016-11-11 | 英特威特國際股份有限公司 | Isoxazoline compositions and their use as antiparasitics |
US8318757B2 (en) | 2007-09-10 | 2012-11-27 | Nissan Chemical Industries, Ltd. | Substituted isoxazoline compound and pest control agent |
WO2009045999A1 (en) | 2007-10-03 | 2009-04-09 | E. I. Du Pont De Nemours And Company | Naphthalene isoxazoline compounds for control of invertebrate pests |
-
2008
- 2008-07-31 TW TW103118216A patent/TWI600639B/en active
- 2008-07-31 TW TW106102361A patent/TWI649303B/en active
- 2008-07-31 TW TW97129034A patent/TWI461411B/en active
- 2008-08-04 PT PT87970919T patent/PT2176244T/en unknown
- 2008-08-04 BR BRPI0814153A patent/BRPI0814153B8/en active IP Right Grant
- 2008-08-04 ES ES08797091.9T patent/ES2587386T3/en active Active
- 2008-08-04 CA CA2693067A patent/CA2693067C/en active Active
- 2008-08-04 KR KR1020157017534A patent/KR20150082693A/en not_active Application Discontinuation
- 2008-08-04 JP JP2010521081A patent/JP5965102B2/en active Active
- 2008-08-04 CN CN201610091532.XA patent/CN105693646A/en active Pending
- 2008-08-04 MY MYPI2014000219A patent/MY176115A/en unknown
- 2008-08-04 MX MX2013011829A patent/MX337588B/en unknown
- 2008-08-04 MX MX2010001773A patent/MX2010001773A/en active IP Right Grant
- 2008-08-04 MY MYPI20100137 patent/MY150980A/en unknown
- 2008-08-04 AU AU2008289321A patent/AU2008289321B2/en active Active
- 2008-08-04 CN CN200880103362A patent/CN101855215A/en active Pending
- 2008-08-04 EP EP08797091.9A patent/EP2176244B1/en active Active
- 2008-08-04 KR KR1020107005776A patent/KR101597839B1/en active Protection Beyond IP Right Term
- 2008-08-04 RU RU2010109881/04A patent/RU2536039C2/en active
- 2008-08-04 WO PCT/US2008/072074 patent/WO2009025983A2/en active Application Filing
- 2008-08-04 US US12/679,382 patent/US8217180B2/en active Active
- 2008-08-15 AR ARP080103565 patent/AR067948A1/en active IP Right Grant
-
2010
- 2010-01-06 IL IL203174A patent/IL203174A/en active IP Right Grant
- 2010-01-12 ZA ZA2010/00214A patent/ZA201000214B/en unknown
- 2010-02-17 CO CO10018337A patent/CO6260136A2/en active IP Right Grant
- 2010-10-21 HK HK10109984.7A patent/HK1143373A1/en unknown
-
2012
- 2012-07-09 US US13/544,113 patent/US8513431B2/en active Active
-
2014
- 2014-06-18 JP JP2014125041A patent/JP2014221775A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009001942A1 (en) * | 2007-06-27 | 2008-12-31 | Nissan Chemical Industries, Ltd. | Method for production of 3-hydroxypropan-1-one compound, method for production of 2-propen-1-one compound, and method for production of isoxazoline compound |
Non-Patent Citations (5)
Title |
---|
A. A. H. RAGAILA ET AL.: "Newer heterocycles and carbamates from naphthyl chalcones", EGYPTIAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 29, no. 1-4, 1988, NATIONAL INFORMATION AND DOCUMENTATION CENTRE, CAIRO; EG, pages 71 - 87, ISSN: 0301-5068 * |
DATABASE CASREACT CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1988, XP002516318, retrieved from STN Database accession no. 111:115084 * |
DATABASE CASREACT CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1996, XP002516333, retrieved from STN Database accession no. 126:31303 * |
O. A. KUZNETSOVA: "Synthesis of fluorinated functionalized isoxazolinones", ROSSIISKAYA AKADEMIYA NAUK. IZVESTIYA. SERIYA KHIMICHESKAYA, no. 5, 1996, IZDATEL'STVO NAUKA; RU, pages 1306 - 1307, ISSN: 1026-3500 * |
R. R. KAMBLE ET AL.: "An Efficient Synthesis of Pharmacologically Active Derivatives of 1,3,4-Oxadiazoles", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 43, no. 345, 2006, PROVO, UT; US, pages 345 - 352, XP002516317, ISSN: 0022-152X * |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2009025983A3 (en) | Method for preparing 5-haloalkyl-4,5-dihydroisoxazole derivatives | |
WO2008071918A8 (en) | Pyrido-pyrazine derivatives useful as herbicidal compounds | |
WO2008110355A8 (en) | Quinoline derivatives as fungicides | |
WO2009019015A8 (en) | Novel herbicides | |
HK1158627A1 (en) | 1-heterocyclylsulfonyl, 2-aminomethyl, 5-(hetero-)aryl substituted 1-h- pyrrole derivatives as acid secretion inhibitors | |
WO2009087098A3 (en) | Quinoline derivatives and their use as fungicides | |
WO2006058700A8 (en) | Acetamide compounds as fungicides | |
WO2009049716A3 (en) | Novel fungicides | |
WO2007000339A8 (en) | Bicyclic derivatives as p38 kinase inhibitors | |
WO2009079008A8 (en) | Benzopyrans and analogs as rho kinase inhibitors | |
WO2010027236A3 (en) | Fused heterocyclic compound | |
MX2009003257A (en) | Process for synthesis of phenoxy diaminopyrimidine derivatives. | |
WO2007062308A3 (en) | Homo- and heterocyclic compounds suitable as cetp inhibitors | |
WO2007147771A3 (en) | Tetralin and indane derivatives and uses thereof | |
WO2006130080A3 (en) | Quinoline derivatives as nk3 anatgonists | |
WO2009007115A8 (en) | Tropane derivatives useful as pesticides | |
IL179346A0 (en) | 3-(4-(2-dihydroisoxazol-3-ylpyridin-5-yl)phenyl)-5-triazol-1-ylmethyloxazolidin-2-one derivatives as mao inhibitors for the treatment of bacterial infections | |
IL185545A0 (en) | Method of preparation of pure 4-pyrrolidinophenylbenzyl ether derivatives as maob inhibitors | |
WO2006079720A8 (en) | Novel heterocyclic oxime derivatives, method for preparing same and use thereof as hypoglycaemic or hypolipidemic agents | |
WO2007048841A3 (en) | Novel indole-containing beta agonists, method for producing them and their use as drugs | |
WO2006061126A3 (en) | Dibenzoxazepinone derivatives | |
WO2009030450A8 (en) | Novel herbicides | |
WO2008019030A3 (en) | Modified azole compounds as antiinfective agents | |
WO2005102323A3 (en) | Process of preparing esters and ethers of probucol and derivatives thereof | |
WO2008089005A3 (en) | Renin inhibitors |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 200880103362.6 Country of ref document: CN |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 08797091 Country of ref document: EP Kind code of ref document: A2 |
|
DPE1 | Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101) | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2008289321 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 203174 Country of ref document: IL |
|
WWE | Wipo information: entry into national phase |
Ref document number: 197/DELNP/2010 Country of ref document: IN |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2693067 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2008797091 Country of ref document: EP |
|
ENP | Entry into the national phase |
Ref document number: 2008289321 Country of ref document: AU Date of ref document: 20080804 Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: MX/A/2010/001773 Country of ref document: MX |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2010521081 Country of ref document: JP Ref document number: PI 2010000137 Country of ref document: MY |
|
WWE | Wipo information: entry into national phase |
Ref document number: 10018337 Country of ref document: CO |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
ENP | Entry into the national phase |
Ref document number: 20107005776 Country of ref document: KR Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2010109881 Country of ref document: RU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 12679382 Country of ref document: US |
|
WWE | Wipo information: entry into national phase |
Ref document number: A201000552 Country of ref document: UA |
|
ENP | Entry into the national phase |
Ref document number: PI0814153 Country of ref document: BR Kind code of ref document: A2 Effective date: 20100210 |