WO2009023495A3 - Bisubstrate inhibitors of adenylosuccinate synthetase - Google Patents

Bisubstrate inhibitors of adenylosuccinate synthetase Download PDF

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Publication number
WO2009023495A3
WO2009023495A3 PCT/US2008/072375 US2008072375W WO2009023495A3 WO 2009023495 A3 WO2009023495 A3 WO 2009023495A3 US 2008072375 W US2008072375 W US 2008072375W WO 2009023495 A3 WO2009023495 A3 WO 2009023495A3
Authority
WO
WIPO (PCT)
Prior art keywords
adenylosuccinate synthetase
alkyl
inhibitors
bisubstrate inhibitors
absent
Prior art date
Application number
PCT/US2008/072375
Other languages
French (fr)
Other versions
WO2009023495A2 (en
Inventor
Wolfgang Wrasidlo
Gregory I Elliott
Dennis A Carson
Michael Rosenbach
Original Assignee
Univ California
Wolfgang Wrasidlo
Gregory I Elliott
Dennis A Carson
Michael Rosenbach
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California, Wolfgang Wrasidlo, Gregory I Elliott, Dennis A Carson, Michael Rosenbach filed Critical Univ California
Publication of WO2009023495A2 publication Critical patent/WO2009023495A2/en
Publication of WO2009023495A3 publication Critical patent/WO2009023495A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/25—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups C12Q1/26 - C12Q1/66
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides compound having the general structure (A) or pharmaceutically acceptable salts thereof: (A) wherein each of R1 and R2 can be, independently, any one of-H, a halogen, -NH2, -OH, - NH-R3, and -O-R3; each of G1, G2, and G4, can be, independently any of CH, N, O, and S; G3 can be any Of CH2, NH, O; and S; or G3 and/or G4 can be C=O; G5 can be any of C and N; L can be absent or be any of O, NH, and S; R3 can be any of-H, an C1-C18 alkyl, an aryl,- C(O)-H, and -C(O)-alkyl; R4 can be any of -H, -C(O)O-; and -C(O)-R3; R5 can be any of - H, an C1 -C18 alkyl, or an aryl; M can be absent or be any Of -CH2-; -NH-; -NH-C(O)-; -O-, and -S-; and n is an integer having the value between 1 and 6. The compounds having the general structure A can serve as inhibitors of adenylosuccinate synthetase.
PCT/US2008/072375 2007-08-10 2008-08-06 Bisubstrate inhibitors of adenylosuccinate synthetase WO2009023495A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95513307P 2007-08-10 2007-08-10
US60/955,133 2007-08-10

Publications (2)

Publication Number Publication Date
WO2009023495A2 WO2009023495A2 (en) 2009-02-19
WO2009023495A3 true WO2009023495A3 (en) 2009-04-16

Family

ID=40351411

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/072375 WO2009023495A2 (en) 2007-08-10 2008-08-06 Bisubstrate inhibitors of adenylosuccinate synthetase

Country Status (1)

Country Link
WO (1) WO2009023495A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8552032B2 (en) 2009-12-18 2013-10-08 Janssen Pharmaceutica Nv Bicyclic derivatives useful as inhibitors of DPP-1
WO2018118808A1 (en) 2016-12-19 2018-06-28 The Broad Institute, Inc. Methods of treating autism spectrum disorders

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0974362A1 (en) * 1997-03-13 2000-01-26 Chugai Seiyaku Kabushiki Kaisha Drugs containing enzyme inhibitors as the active ingredient

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0974362A1 (en) * 1997-03-13 2000-01-26 Chugai Seiyaku Kabushiki Kaisha Drugs containing enzyme inhibitors as the active ingredient

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HEIM D.R. ET AL.: "hydantocidin: a possible proherbicide inhibiting purine biosynthesis at the site of adenylosuccinate synthetase", PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY., vol. 53, no. 2, October 1995 (1995-10-01), pages 138 - 145 *
HONGYING SUN ET AL.: "Molecular cloning and characterization of a novel muscle adenylosuccinate synthetase, AdSSL1, from human bone marrow stromal cells", MOLECULAR AND CELLULAR BIOCHEMISTRY., vol. 269, no. 1, January 2005 (2005-01-01), pages 85 - 94, XP019288647 *
IANCU C.V. ET AL.: "Recombinant mouse muscle adenylosuccinate synthetase", THE JOURNAL OF BIOLOGICAL CHEMISTRY., vol. 276, no. 45, November 2001 (2001-11-01), pages 42146 - 42152 *
WALTERS E.W. ET AL.: "Adenylosuccinate synthetase from Maize", PLANT PHYSIOLOGY, vol. 114, no. 2, June 1997 (1997-06-01), pages 549 - 555 *

Also Published As

Publication number Publication date
WO2009023495A2 (en) 2009-02-19

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