WO2009020211A1 - Novel method for producing α-methyl-β-ketoester - Google Patents

Novel method for producing α-methyl-β-ketoester Download PDF

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Publication number
WO2009020211A1
WO2009020211A1 PCT/JP2008/064335 JP2008064335W WO2009020211A1 WO 2009020211 A1 WO2009020211 A1 WO 2009020211A1 JP 2008064335 W JP2008064335 W JP 2008064335W WO 2009020211 A1 WO2009020211 A1 WO 2009020211A1
Authority
WO
WIPO (PCT)
Prior art keywords
ketoester
methyl
producing
novel method
disclosed
Prior art date
Application number
PCT/JP2008/064335
Other languages
French (fr)
Japanese (ja)
Inventor
Ken-Ichi Kurihara
Hiroshi Kurihara
Original Assignee
Meiji Seika Kaisha, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Kaisha, Ltd. filed Critical Meiji Seika Kaisha, Ltd.
Priority to JP2009526505A priority Critical patent/JP5275235B2/en
Publication of WO2009020211A1 publication Critical patent/WO2009020211A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Disclosed is a method for simply producing an α-methyl-β-ketoester under mild reaction conditions. This method is applicable to mass-synthesis. Specifically disclosed is a method for producing an α-methyl-β-ketoester, which comprises a process wherein a β-ketoester compound is reacted with at least two methylating agents in the presence of an inorganic base.
PCT/JP2008/064335 2007-08-08 2008-08-08 Novel method for producing α-methyl-β-ketoester WO2009020211A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009526505A JP5275235B2 (en) 2007-08-08 2008-08-08 Novel production method of α-methyl-β-ketoester

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007206471 2007-08-08
JP2007-206471 2007-08-08

Publications (1)

Publication Number Publication Date
WO2009020211A1 true WO2009020211A1 (en) 2009-02-12

Family

ID=40341438

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/064335 WO2009020211A1 (en) 2007-08-08 2008-08-08 Novel method for producing α-methyl-β-ketoester

Country Status (3)

Country Link
JP (1) JP5275235B2 (en)
TW (1) TW200925147A (en)
WO (1) WO2009020211A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012073635A1 (en) * 2010-11-29 2012-06-07 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 Novel process for production of α-methyl-β-ketoester

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4934661B1 (en) * 1969-12-08 1974-09-17
WO2004007420A1 (en) * 2002-07-11 2004-01-22 Meiji Seika Kaisha, Ltd. PROCESS FOR PRODUCING α-METHYL-ß-KETO ESTER

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4934661B1 (en) * 1969-12-08 1974-09-17
WO2004007420A1 (en) * 2002-07-11 2004-01-22 Meiji Seika Kaisha, Ltd. PROCESS FOR PRODUCING α-METHYL-ß-KETO ESTER

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
YOSHIHISA OZOE ET AL.: "Synthesis and Some Special Characteristics of Bicyclic Phosphate", GABA ANTAGONISTS, AGRICULTURAL AND BIOLOGICAL CHEMISTRY, vol. 46, no. 2, 1982, pages 411 - 418 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012073635A1 (en) * 2010-11-29 2012-06-07 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 Novel process for production of α-methyl-β-ketoester

Also Published As

Publication number Publication date
JPWO2009020211A1 (en) 2010-11-04
JP5275235B2 (en) 2013-08-28
TW200925147A (en) 2009-06-16

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