WO2009016577A3 - A pharmaceutical composition comprising atorvastatin and niacin - Google Patents

A pharmaceutical composition comprising atorvastatin and niacin Download PDF

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Publication number
WO2009016577A3
WO2009016577A3 PCT/IB2008/053014 IB2008053014W WO2009016577A3 WO 2009016577 A3 WO2009016577 A3 WO 2009016577A3 IB 2008053014 W IB2008053014 W IB 2008053014W WO 2009016577 A3 WO2009016577 A3 WO 2009016577A3
Authority
WO
WIPO (PCT)
Prior art keywords
niacin
atorvastatin
pharmaceutical composition
component containing
release component
Prior art date
Application number
PCT/IB2008/053014
Other languages
French (fr)
Other versions
WO2009016577A2 (en
Inventor
Sumit Madan
Rajesh S Shear
Venkateshwara Rathinasabapathy
Vinod Arora
Original Assignee
Ranbaxy Lab Ltd
Sumit Madan
Rajesh S Shear
Venkateshwara Rathinasabapathy
Vinod Arora
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Lab Ltd, Sumit Madan, Rajesh S Shear, Venkateshwara Rathinasabapathy, Vinod Arora filed Critical Ranbaxy Lab Ltd
Publication of WO2009016577A2 publication Critical patent/WO2009016577A2/en
Publication of WO2009016577A3 publication Critical patent/WO2009016577A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pyrrole Compounds (AREA)

Abstract

This invention relates to a pharmaceutical composition of atorvastatin and niacin comprising an immediate release component containing atorvastatin and a sustained release component containing niacin wherein the two components are not in intimate contact with each other.
PCT/IB2008/053014 2007-07-27 2008-07-27 A pharmaceutical composition comprising atorvastatin and niacin WO2009016577A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1587DE2007 2007-07-27
IN1587/DEL/2007 2007-07-27

Publications (2)

Publication Number Publication Date
WO2009016577A2 WO2009016577A2 (en) 2009-02-05
WO2009016577A3 true WO2009016577A3 (en) 2009-03-26

Family

ID=40162601

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/053014 WO2009016577A2 (en) 2007-07-27 2008-07-27 A pharmaceutical composition comprising atorvastatin and niacin

Country Status (1)

Country Link
WO (1) WO2009016577A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110123609A1 (en) * 2008-07-19 2011-05-26 Sunil Shantwan Borude Multiple unit dosage form of niacin

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1792616A1 (en) * 1997-07-31 2007-06-06 Kos Life Sciences, Inc. Composition comprising an HMG-CoA inhibitor and a nicotinic acid compound for treating hyperlipidemia
WO2007069827A1 (en) * 2005-12-14 2007-06-21 Chong Kun Dang Pharmaceutical Corp. Pharmaceutical composition with extended release layer and fast release layer for treatment of hyperlipidemia and arteriosclerosis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1792616A1 (en) * 1997-07-31 2007-06-06 Kos Life Sciences, Inc. Composition comprising an HMG-CoA inhibitor and a nicotinic acid compound for treating hyperlipidemia
WO2007069827A1 (en) * 2005-12-14 2007-06-21 Chong Kun Dang Pharmaceutical Corp. Pharmaceutical composition with extended release layer and fast release layer for treatment of hyperlipidemia and arteriosclerosis

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MALIK S ET AL: "NIACIN, LIPIDS, AND HEART DISEASE", CURRENT CARDIOLOGY REPORTS, CURRENT SCIENCE, PHILADELPHIA, PA, US, vol. 5, no. 6, 1 November 2003 (2003-11-01), pages 470 - 476, XP009022489, ISSN: 1523-3782 *
MORGAN J M ET AL: "COMBINATION THERAPY IN THE CONTROL OF COMBINED HYPERLIPIDEMIA: THE ROLE OF EXTENDED RELEASE NIACIN", CARDIOVASCULAR REVIEWS AND REPORTS, CARDIOVASCULAR REVIEWS AND REPORTS, GREENWICH, CT, US, vol. 21, no. 1, 1 January 2000 (2000-01-01), pages 12 - 18, XP001073755, ISSN: 0197-3118 *

Also Published As

Publication number Publication date
WO2009016577A2 (en) 2009-02-05

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