WO2009016081A3 - Benzoind0l-2-one derivatives for use in therapy - Google Patents

Benzoind0l-2-one derivatives for use in therapy Download PDF

Info

Publication number
WO2009016081A3
WO2009016081A3 PCT/EP2008/059664 EP2008059664W WO2009016081A3 WO 2009016081 A3 WO2009016081 A3 WO 2009016081A3 EP 2008059664 W EP2008059664 W EP 2008059664W WO 2009016081 A3 WO2009016081 A3 WO 2009016081A3
Authority
WO
WIPO (PCT)
Prior art keywords
alkyl
benzoind0l
therapy
derivatives
absent
Prior art date
Application number
PCT/EP2008/059664
Other languages
French (fr)
Other versions
WO2009016081A2 (en
Inventor
Jacob Westman
Bjoern Kull
Patric Stenberg
Original Assignee
Actar Ab
Jacob Westman
Bjoern Kull
Patric Stenberg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actar Ab, Jacob Westman, Bjoern Kull, Patric Stenberg filed Critical Actar Ab
Publication of WO2009016081A2 publication Critical patent/WO2009016081A2/en
Publication of WO2009016081A3 publication Critical patent/WO2009016081A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A compound of formula (I) wherein A is (C0-C1)-alkyl; R1 is (C1-C6)-alkyl when A is C1-alkyl and R1 is absent when A is C0-alkyl; R2 is optionally substituted mono- or polycyclic carbocyclyl or oxygen-containing heterocyclyl, R3 is H oroptionally substituted -S(O)2-NH-phenyl, and pharmaceutically acceptable salts thereof, for use as a medicament, e.g. in the treatment of inflammatory diseases and cancer.
PCT/EP2008/059664 2007-08-02 2008-07-23 Benzoind0l-2-one derivatives for use in therapy WO2009016081A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95363307P 2007-08-02 2007-08-02
US60/953,633 2007-08-02

Publications (2)

Publication Number Publication Date
WO2009016081A2 WO2009016081A2 (en) 2009-02-05
WO2009016081A3 true WO2009016081A3 (en) 2009-06-18

Family

ID=40304954

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/059664 WO2009016081A2 (en) 2007-08-02 2008-07-23 Benzoind0l-2-one derivatives for use in therapy

Country Status (1)

Country Link
WO (1) WO2009016081A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100961891B1 (en) * 2008-02-01 2010-06-09 연세대학교 산학협력단 Pharmaceutical Compositions for Inhibiting Angiogenesis
ES2732832T3 (en) 2010-07-30 2019-11-26 Smartdyelivery Gmbh Measurement procedure to determine a function of an organ
CN104530014B (en) * 2013-12-25 2018-03-20 中国科学院广州生物医药与健康研究院 Sulfamide compound of the dihydrobenzo of 2 oxo 1,2 [cd] indoles 6 and combinations thereof and application
CN105272904B (en) * 2014-07-18 2019-04-09 中国科学院广州生物医药与健康研究院 N- phenylamide compound and its application
CN105985282B (en) 2015-01-28 2020-12-08 中国科学院广州生物医药与健康研究院 2-oxo-1, 2-dihydrobenzo [ cd ] indole compound and application thereof
KR102343865B1 (en) * 2018-11-09 2021-12-28 한국화학연구원 Compound inhibiting YAP-TEAD interaction and pharmaceutical composition for treating or preventing cancer comprising the same as an active ingredient

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050137190A1 (en) * 2003-08-08 2005-06-23 Gonzalez Jesus E.Iii Compositions useful as inhibitors of voltage-gated sodium channels
WO2007005541A2 (en) * 2005-06-30 2007-01-11 Philadelphia Health & Education Corporation, D/B/A Drexel University College Of Medicine Small molecule inhibitors against west nile virus replication

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050137190A1 (en) * 2003-08-08 2005-06-23 Gonzalez Jesus E.Iii Compositions useful as inhibitors of voltage-gated sodium channels
WO2007005541A2 (en) * 2005-06-30 2007-01-11 Philadelphia Health & Education Corporation, D/B/A Drexel University College Of Medicine Small molecule inhibitors against west nile virus replication

Also Published As

Publication number Publication date
WO2009016081A2 (en) 2009-02-05

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