WO2009014372A3 - Dispersible tablet comprising coated drug-containing particles and method for the preparation thereof - Google Patents
Dispersible tablet comprising coated drug-containing particles and method for the preparation thereof Download PDFInfo
- Publication number
- WO2009014372A3 WO2009014372A3 PCT/KR2008/004298 KR2008004298W WO2009014372A3 WO 2009014372 A3 WO2009014372 A3 WO 2009014372A3 KR 2008004298 W KR2008004298 W KR 2008004298W WO 2009014372 A3 WO2009014372 A3 WO 2009014372A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- dispersible tablet
- drug
- containing particles
- preparation
- coated drug
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a dispersible tablet comprising a plurality of a coated drug-containing particles and a method for preparing said dispersible tablet. The inventive dispersible tablet comprising (a) a plurality of a drug-containing particle having a coating layer on the surface thereof; (b) a binding agent for protecting the coating layer; and (c) a pharmaceutically acceptable excipient, is capable of: maintaining a suitable hardness to prevent from the breakage thereof during the packing, circulating or storing period; enhancing the patient compliance through masking the drug bitterness; and disintegrating and dispersing rapidly enough to be easily administered to young children or old people having difficulty in swallowing a conventional oral formulation.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2008800253313A CN101754754B (en) | 2007-07-23 | 2008-07-23 | Dispersible tablet comprising coated drug-containing particles and method for the preparation thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2007-0073396 | 2007-07-23 | ||
KR1020070073396A KR101436516B1 (en) | 2007-07-23 | 2007-07-23 | Dispersible tablet containing coated pellet and preparation method thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009014372A2 WO2009014372A2 (en) | 2009-01-29 |
WO2009014372A3 true WO2009014372A3 (en) | 2009-03-19 |
Family
ID=40281977
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/KR2008/004298 WO2009014372A2 (en) | 2007-07-23 | 2008-07-23 | Dispersible tablet comprising coated drug-containing particles and method for the preparation thereof |
Country Status (3)
Country | Link |
---|---|
KR (1) | KR101436516B1 (en) |
CN (1) | CN101754754B (en) |
WO (1) | WO2009014372A2 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102475689B (en) * | 2010-11-30 | 2015-04-01 | 杭州赛利药物研究所有限公司 | Suspension dispersible tablets and preparation method |
CN103040776A (en) * | 2012-12-14 | 2013-04-17 | 四川美大康药业股份有限公司 | Preparation method of azithromycin dispersible tablet granule coating |
ITUA20163981A1 (en) * | 2016-05-31 | 2017-12-01 | Zambon Spa | PHARMACEUTICAL COMPOSITIONS INCLUDING SAFINAMID |
CN112076168A (en) * | 2020-09-24 | 2020-12-15 | 丽珠集团丽珠制药厂 | Roxithromycin dispersible tablet and preparation method thereof |
CN115501196B (en) * | 2022-10-31 | 2023-04-11 | 江苏神龙药业有限公司 | Preparation method of roxithromycin dispersible tablet |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6090827A (en) * | 1997-05-28 | 2000-07-18 | Astrazeneca Ab | Pharmaceutical formulation of omeprazole |
WO2004087112A1 (en) * | 2003-03-31 | 2004-10-14 | Korea United Pharm, Inc. | Manufacturing method and formulation for bitter taste masked oral dosage form of clarithromycin |
US20040241235A1 (en) * | 2001-03-09 | 2004-12-02 | Christophe Lebon | Granules and granules coated with a masked taste |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU3731699A (en) * | 1998-05-18 | 1999-12-06 | Takeda Chemical Industries Ltd. | Orally disintegrable tablets |
CN1543971A (en) * | 2003-07-02 | 2004-11-10 | 北京博尔达生物技术开发有限公司 | Oral disintegrating tablet and its preparation of compound red sage root |
CN1274298C (en) * | 2003-11-06 | 2006-09-13 | 常州市第四制药厂有限公司 | Disintegrants for deodoring effectively and their preparation |
CN100376258C (en) * | 2005-05-27 | 2008-03-26 | 北京科信必成医药科技发展有限公司 | Orally disintegrating tablet of 'Tianli Bolus' for treating heart disease and its preparation process |
CN100448431C (en) * | 2005-10-17 | 2009-01-07 | 重庆医药工业研究院有限责任公司 | Oral disintegrated Anfenmame tablet for treating children's cold and its prepn |
-
2007
- 2007-07-23 KR KR1020070073396A patent/KR101436516B1/en not_active IP Right Cessation
-
2008
- 2008-07-23 CN CN2008800253313A patent/CN101754754B/en not_active Expired - Fee Related
- 2008-07-23 WO PCT/KR2008/004298 patent/WO2009014372A2/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6090827A (en) * | 1997-05-28 | 2000-07-18 | Astrazeneca Ab | Pharmaceutical formulation of omeprazole |
US20040241235A1 (en) * | 2001-03-09 | 2004-12-02 | Christophe Lebon | Granules and granules coated with a masked taste |
WO2004087112A1 (en) * | 2003-03-31 | 2004-10-14 | Korea United Pharm, Inc. | Manufacturing method and formulation for bitter taste masked oral dosage form of clarithromycin |
Also Published As
Publication number | Publication date |
---|---|
WO2009014372A2 (en) | 2009-01-29 |
KR101436516B1 (en) | 2014-09-02 |
CN101754754B (en) | 2013-06-19 |
CN101754754A (en) | 2010-06-23 |
KR20090010352A (en) | 2009-01-30 |
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