WO2009014347A3 - Stabilized antioxidant-containing particles, process for preparing the same, and composition comprising the same - Google Patents

Stabilized antioxidant-containing particles, process for preparing the same, and composition comprising the same Download PDF

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Publication number
WO2009014347A3
WO2009014347A3 PCT/KR2008/004201 KR2008004201W WO2009014347A3 WO 2009014347 A3 WO2009014347 A3 WO 2009014347A3 KR 2008004201 W KR2008004201 W KR 2008004201W WO 2009014347 A3 WO2009014347 A3 WO 2009014347A3
Authority
WO
WIPO (PCT)
Prior art keywords
antioxidant
containing particles
same
coating layer
polymer
Prior art date
Application number
PCT/KR2008/004201
Other languages
French (fr)
Other versions
WO2009014347A2 (en
Inventor
Chul Hwan Kim
Chan Jae Shin
So Yeon Seo
Jung Ae Kwon
Choa Jin Kim
Nam Su Kim
Original Assignee
G1 Biztech Co Ltd
Chul Hwan Kim
Chan Jae Shin
So Yeon Seo
Jung Ae Kwon
Choa Jin Kim
Nam Su Kim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020080069492A external-priority patent/KR20090009722A/en
Application filed by G1 Biztech Co Ltd, Chul Hwan Kim, Chan Jae Shin, So Yeon Seo, Jung Ae Kwon, Choa Jin Kim, Nam Su Kim filed Critical G1 Biztech Co Ltd
Publication of WO2009014347A2 publication Critical patent/WO2009014347A2/en
Publication of WO2009014347A3 publication Critical patent/WO2009014347A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/11—Encapsulated compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/25—Silicon; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4986—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with sulfur as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/676—Ascorbic acid, i.e. vitamin C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/731—Cellulose; Quaternized cellulose derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A61K2800/522—Antioxidants; Radical scavengers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Birds (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention provides stabilized antioxidant-containing particles, which comprises a core comprising an antioxidant; a polymer-coating layer formed by coating a polymer on the core; and an inorganic material-coating layer formed by coating inorganic silica on the polymer-coating layer and a process for preparing the same. The present invention also provides a pharmaceutical composition or a cosmetic composition including the antioxidant-containing particles. The antioxidant-containing particles according to the present invention include at least one polymer-coating layer and an inorganic material-coating layer, thereby having excellent stability in an aqueous medium. Thus, the antioxidant-containing particles can be usefully applied to pharmaceutical compositions and cosmetic compositions, since those can minimize denaturation caused by environmental factors such as temperature, light, oxygen, and water, even when being stored in an aqueous composition for a long period of time.
PCT/KR2008/004201 2007-07-20 2008-07-18 Stabilized antioxidant-containing particles, process for preparing the same, and composition comprising the same WO2009014347A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR20070072721 2007-07-20
KR10-2007-0072721 2007-07-20
KR10-2008-0069492 2008-07-17
KR1020080069492A KR20090009722A (en) 2007-07-20 2008-07-17 Stabilized antioxidant-containing particles, process for preparing the same, and composition comprising the same

Publications (2)

Publication Number Publication Date
WO2009014347A2 WO2009014347A2 (en) 2009-01-29
WO2009014347A3 true WO2009014347A3 (en) 2009-03-12

Family

ID=40281965

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2008/004201 WO2009014347A2 (en) 2007-07-20 2008-07-18 Stabilized antioxidant-containing particles, process for preparing the same, and composition comprising the same

Country Status (1)

Country Link
WO (1) WO2009014347A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9125825B2 (en) 2009-04-22 2015-09-08 Medskin Solutions Dr. Suwelack Ag Freeze-dried molded article containing magnesium ascorbyl phosphate
US20120183587A1 (en) * 2011-01-18 2012-07-19 Mitsunori Ono Flavonol compositions
CA3016464A1 (en) 2016-03-08 2017-09-14 Soo-Young Kang Long lasting cosmetic compositions
AU2018333932B2 (en) 2017-09-13 2024-05-02 Living Proof, Inc. Long lasting cosmetic compositions
EP3681921A2 (en) 2017-09-13 2020-07-22 Living Proof, Inc. Color protectant compositions
AU2018370210B2 (en) 2017-11-20 2024-09-26 Living Proof, Inc. Properties for achieving long-lasting cosmetic performance
BR112020021902B1 (en) 2018-04-27 2024-02-20 Living Proof, Inc POLYURETHANE-UREA COSMETIC COMPOSITIONS FOR HAIR TREATMENT, METHOD FOR PRESERVING WAVELIES IN HUMAN HAIR AND THE USES OF POLYURETHANE-UREA

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4486435A (en) * 1983-05-16 1984-12-04 Basf Wyandotte Corporation Spray-dried vitamin powders using hydrophobic silica
US20030124075A1 (en) * 2001-11-28 2003-07-03 L'oreal Use of a composition containing at least one oxidation-sensitive hydrophilic active principle and at least one N-vinylimidazole polymer or copolymer
US20050008596A1 (en) * 2003-05-27 2005-01-13 L'oreal Composition containing an oxidation-sensitive active principle and a polyisobutylene polymer
KR20050092626A (en) * 2004-03-16 2005-09-22 주식회사 디피아이 솔루션스 Composition for stabilizing vitamin c and its derivatives in water phase and method for stabilizing vitamin c and its derivatives using thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4486435A (en) * 1983-05-16 1984-12-04 Basf Wyandotte Corporation Spray-dried vitamin powders using hydrophobic silica
US20030124075A1 (en) * 2001-11-28 2003-07-03 L'oreal Use of a composition containing at least one oxidation-sensitive hydrophilic active principle and at least one N-vinylimidazole polymer or copolymer
US20050008596A1 (en) * 2003-05-27 2005-01-13 L'oreal Composition containing an oxidation-sensitive active principle and a polyisobutylene polymer
KR20050092626A (en) * 2004-03-16 2005-09-22 주식회사 디피아이 솔루션스 Composition for stabilizing vitamin c and its derivatives in water phase and method for stabilizing vitamin c and its derivatives using thereof

Also Published As

Publication number Publication date
WO2009014347A2 (en) 2009-01-29

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