WO2009013901A1 - Novel compound, method for production of the compound, pharmaceutical composition, anti-tumor agent, and use of the compound - Google Patents

Novel compound, method for production of the compound, pharmaceutical composition, anti-tumor agent, and use of the compound Download PDF

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Publication number
WO2009013901A1
WO2009013901A1 PCT/JP2008/001969 JP2008001969W WO2009013901A1 WO 2009013901 A1 WO2009013901 A1 WO 2009013901A1 JP 2008001969 W JP2008001969 W JP 2008001969W WO 2009013901 A1 WO2009013901 A1 WO 2009013901A1
Authority
WO
WIPO (PCT)
Prior art keywords
compound
ester derivative
tumor agent
pharmaceutical composition
production
Prior art date
Application number
PCT/JP2008/001969
Other languages
French (fr)
Japanese (ja)
Inventor
Ritsuko Narasaki
Shohei Kumagai
Keiji Hasumi
Original Assignee
Tokyo University Of Agriculture And Technology
Tms Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tokyo University Of Agriculture And Technology, Tms Co., Ltd. filed Critical Tokyo University Of Agriculture And Technology
Publication of WO2009013901A1 publication Critical patent/WO2009013901A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

[PROBLEMS] To provide a novel anti-tumor agent. [MEANS FOR SOLVING PROBLEMS] Disclosed are: an ester derivative of koningic acid (a compound shown below; wherein R represents an organic group); a pharmaceutical composition comprising at least the compound; and an anti-tumor agent comprising koningic acid or an ester derivative thereof. Koningic acid or an ester derivative thereof can prevent a tumor by administering it to a human body, another mammal or the like in an effective amount. When an ester derivative of koningic acid is used, the ester derivative can particularly reduce erythrocytic toxicity to a low level and therefore produces reduced adverse side effects.
PCT/JP2008/001969 2007-07-23 2008-07-23 Novel compound, method for production of the compound, pharmaceutical composition, anti-tumor agent, and use of the compound WO2009013901A1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2007191003 2007-07-23
JP2007-191003 2007-07-23
JP2008-016979 2008-01-28
JP2008016979 2008-01-28
JP2008-052747 2008-03-04
JP2008052747 2008-03-04

Publications (1)

Publication Number Publication Date
WO2009013901A1 true WO2009013901A1 (en) 2009-01-29

Family

ID=40281161

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/001969 WO2009013901A1 (en) 2007-07-23 2008-07-23 Novel compound, method for production of the compound, pharmaceutical composition, anti-tumor agent, and use of the compound

Country Status (1)

Country Link
WO (1) WO2009013901A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011016351A1 (en) * 2009-08-07 2011-02-10 学校法人神戸学院 Dna synthase inhibitors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07277971A (en) * 1994-04-01 1995-10-24 Kobe Steel Ltd Antitumor agent, selective cytotoxic agent for human tumor cell, microbial strain producing heptelidic acid chlorohydrin and its production

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07277971A (en) * 1994-04-01 1995-10-24 Kobe Steel Ltd Antitumor agent, selective cytotoxic agent for human tumor cell, microbial strain producing heptelidic acid chlorohydrin and its production

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DANISHEFSKY S.J. ET AL.: "Total synthesis of (plus or minus)-heptelidic acid", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 110, no. 24, 1988, pages 8129 - 8133 *
ITOH Y. ET AL.: "Structure of heptelidic acid, a new sesquiterpene antibiotic from fungi", JOURNAL OF ANTIBIOTICS, vol. 33, no. 5, 1980, pages 525 - 526 *
TANAKA Y. ET AL.: "Antimalarial activity of radical, heptelidic acid and other fungal metabolite", THE JOURNAL OF ANTIBIOTICS, vol. 51, no. 2, 1998, pages 153 - 160 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011016351A1 (en) * 2009-08-07 2011-02-10 学校法人神戸学院 Dna synthase inhibitors
JP2011037730A (en) * 2009-08-07 2011-02-24 Kobe Gakuin Dna synthase inhibitor

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