WO2009010298A8 - Paullone derivatives and its use - Google Patents

Paullone derivatives and its use Download PDF

Info

Publication number
WO2009010298A8
WO2009010298A8 PCT/EP2008/005908 EP2008005908W WO2009010298A8 WO 2009010298 A8 WO2009010298 A8 WO 2009010298A8 EP 2008005908 W EP2008005908 W EP 2008005908W WO 2009010298 A8 WO2009010298 A8 WO 2009010298A8
Authority
WO
WIPO (PCT)
Prior art keywords
relates
present
paullone derivatives
paullone
derivatives
Prior art date
Application number
PCT/EP2008/005908
Other languages
French (fr)
Other versions
WO2009010298A3 (en
WO2009010298A2 (en
Inventor
Conrad Kunick
Christina Reichwald
Ute Dunkel
Charles Jaffe
Orly Shimony
Original Assignee
Univ Braunschweig Tech Carolo Wilhelmina
Yissum Res Dev Co
Conrad Kunick
Christina Reichwald
Ute Dunkel
Charles Jaffe
Orly Shimony
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Braunschweig Tech Carolo Wilhelmina, Yissum Res Dev Co, Conrad Kunick, Christina Reichwald, Ute Dunkel, Charles Jaffe, Orly Shimony filed Critical Univ Braunschweig Tech Carolo Wilhelmina
Publication of WO2009010298A2 publication Critical patent/WO2009010298A2/en
Publication of WO2009010298A8 publication Critical patent/WO2009010298A8/en
Publication of WO2009010298A3 publication Critical patent/WO2009010298A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to new paullone derivatives. In particular, the present invention relates to new paullone derivatives having anti-protozoan activity, in particular, anti-leishmanial activity. In a further aspect, the present invention relates to pharmaceutical compositions containing said paullones.
PCT/EP2008/005908 2007-07-18 2008-07-18 Paullone derivatives and its use WO2009010298A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95039407P 2007-07-18 2007-07-18
US60/950,394 2007-07-18

Publications (3)

Publication Number Publication Date
WO2009010298A2 WO2009010298A2 (en) 2009-01-22
WO2009010298A8 true WO2009010298A8 (en) 2009-03-05
WO2009010298A3 WO2009010298A3 (en) 2009-06-18

Family

ID=40260126

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/005908 WO2009010298A2 (en) 2007-07-18 2008-07-18 Paullone derivatives and its use

Country Status (1)

Country Link
WO (1) WO2009010298A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102924462B (en) * 2012-10-24 2015-01-14 华东师范大学 Method for synthesis of 1,2,3,4,5,9-substituted benzazepine compound
US9572815B2 (en) 2013-03-15 2017-02-21 St. Jude Children's Research Hospital Methods and compositions of p27KIP1 transcriptional modulators
EP3786164A1 (en) 2015-06-18 2021-03-03 Ting Therapeutics LLC Methods and compositions for the prevention and treatment of hearing loss

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE318818T1 (en) * 1998-06-16 2006-03-15 Us Gov Health & Human Serv ANNOULED AZEPINONES AS INHIBITORS OF CYCLIN-DEPENDENT KINASES
FR2804959B1 (en) * 2000-02-15 2006-04-28 Centre Nat Rech Scient USE OF PAULLON DERIVATIVES FOR THE MANUFACTURE OF MEDICAMENTS
EP1757607A1 (en) * 2005-08-24 2007-02-28 Molisa GmbH N5-substituted benzo¬2,3|azepino¬4,5-b|indol-6-ones for treating tropical diseases

Also Published As

Publication number Publication date
WO2009010298A3 (en) 2009-06-18
WO2009010298A2 (en) 2009-01-22

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