WO2009008345A1 - 金属錯体化合物、これを有効成分とする癌治療剤組成物および該金属錯体化合物用の中間体 - Google Patents

金属錯体化合物、これを有効成分とする癌治療剤組成物および該金属錯体化合物用の中間体 Download PDF

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Publication number
WO2009008345A1
WO2009008345A1 PCT/JP2008/062133 JP2008062133W WO2009008345A1 WO 2009008345 A1 WO2009008345 A1 WO 2009008345A1 JP 2008062133 W JP2008062133 W JP 2008062133W WO 2009008345 A1 WO2009008345 A1 WO 2009008345A1
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Prior art keywords
metal complex
complex compound
active ingredient
therapeutic composition
production
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PCT/JP2008/062133
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English (en)
French (fr)
Inventor
Hisao Ekimoto
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Tmrc Co., Ltd.
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Publication date
Application filed by Tmrc Co., Ltd. filed Critical Tmrc Co., Ltd.
Priority to US12/667,741 priority Critical patent/US20110034714A1/en
Priority to EP08790864A priority patent/EP2177525A1/en
Priority to JP2009522605A priority patent/JPWO2009008345A1/ja
Publication of WO2009008345A1 publication Critical patent/WO2009008345A1/ja

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2479—Compounds containing the structure P(=X)n-N-acyl, P(=X)n-N-heteroatom, P(=X)n-N-CN (X = O, S, Se; n = 0, 1)
    • C07F9/2495—Compounds containing the structure P(=X)n-N-acyl, P(=X)n-N-heteroatom, P(=X)n-N-CN (X = O, S, Se; n = 0, 1) containing the structure P(=X)n-N-P (X = O, S, Se; n = 0, 1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/4028—Esters of poly(thio)phosphonic acids containing no further substituents than -PO3H2 groups in free or esterified form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/4028—Esters of poly(thio)phosphonic acids containing no further substituents than -PO3H2 groups in free or esterified form
    • C07F9/4031—Acyclic unsaturated derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/4028—Esters of poly(thio)phosphonic acids containing no further substituents than -PO3H2 groups in free or esterified form
    • C07F9/4034—Cycloaliphatic derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/405—Esters of poly(thio)phosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

　骨吸着性あるいは細胞増殖抑制性が高く、骨転移癌の治療およびその原発癌の治療について高い効果がある金属錯体化合物、該金属錯体化合物またはその生理学的に許容し得る塩を有効成分とする癌治療剤組成物および該金属錯体化合物用の中間体を提供する。 　下記一般式（１）、 （式中、Ｒ１は、各々独立に、分岐又は置換基を有してもよい炭素原子数１～１０のアルキル基または置換基を有してもよい炭素原子数３～３０の環状基、Ｘは、ＣＨＲ２、酸素原子、またはＮＲ５）で表される金属錯体化合物、これを有効成分とする癌治療剤組成物および該金属錯体化合物用の中間体である。
PCT/JP2008/062133 2007-07-06 2008-07-04 金属錯体化合物、これを有効成分とする癌治療剤組成物および該金属錯体化合物用の中間体 WO2009008345A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US12/667,741 US20110034714A1 (en) 2007-07-06 2008-07-04 Metal complex compound, cancer therapeutic agent composition containing the metal complex compound as an active ingredient, and intermediate for the metal complex compound
EP08790864A EP2177525A1 (en) 2007-07-06 2008-07-04 Metal complex compound, cancer therapeutic composition comprising the metal complex compound as active ingredient, and intermediate for production of the metal complex compound
JP2009522605A JPWO2009008345A1 (ja) 2007-07-06 2008-07-04 金属錯体化合物、これを有効成分とする癌治療剤組成物および該金属錯体化合物用の中間体

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007-179040 2007-07-06
JP2007179040 2007-07-06
JP2008034907 2008-02-15
JP2008-034907 2008-02-15

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US (1) US20110034714A1 (ja)
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010535803A (ja) * 2007-08-06 2010-11-25 オハイオ ユニバーシティー ホスファプラチン、ならびにシスプラチンおよびカルボプラチンに対し耐性を有する癌の治療におけるその使用
JP2014520849A (ja) * 2011-07-08 2014-08-25 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 抗癌治療及び画像化並びに骨障害治療のための金属ビスホスホネートナノ粒子
JP2020504140A (ja) * 2017-01-06 2020-02-06 フォスプラティン・セラピューティクス・エルエルシー 骨がんまたは血液がんの治療のための治療薬としてのホスファプラチン化合物

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108409795A (zh) 2010-06-04 2018-08-17 俄亥俄大学 磷铂及其在治疗癌症中的用途
US20130236568A1 (en) * 2011-01-12 2013-09-12 Ohio University Phosphaplatins having anti-angiogenic, anti-metastatic, and pro-apoptotic properties and uses thereof
CN114349794B (zh) * 2021-10-31 2023-11-24 南京医科大学 一种双膦酸铂配合物及其合成方法及应用

Citations (2)

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Publication number Priority date Publication date Assignee Title
US6436386B1 (en) 2000-11-14 2002-08-20 Shearwater Corporation Hydroxyapatite-targeting poly (ethylene glycol) and related polymers
WO2005000858A2 (en) 2003-06-27 2005-01-06 Akira Odani Bisphosphonate complexes

Patent Citations (2)

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US6436386B1 (en) 2000-11-14 2002-08-20 Shearwater Corporation Hydroxyapatite-targeting poly (ethylene glycol) and related polymers
WO2005000858A2 (en) 2003-06-27 2005-01-06 Akira Odani Bisphosphonate complexes

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010535803A (ja) * 2007-08-06 2010-11-25 オハイオ ユニバーシティー ホスファプラチン、ならびにシスプラチンおよびカルボプラチンに対し耐性を有する癌の治療におけるその使用
JP2013227218A (ja) * 2007-08-06 2013-11-07 Ohio Univ ホスファプラチン、ならびにシスプラチンおよびカルボプラチンに対し耐性を有する癌の治療におけるその使用
JP2014520849A (ja) * 2011-07-08 2014-08-25 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 抗癌治療及び画像化並びに骨障害治療のための金属ビスホスホネートナノ粒子
JP2020504140A (ja) * 2017-01-06 2020-02-06 フォスプラティン・セラピューティクス・エルエルシー 骨がんまたは血液がんの治療のための治療薬としてのホスファプラチン化合物
JP7023968B2 (ja) 2017-01-06 2022-02-22 フォスプラティン・セラピューティクス・インコーポレーテッド 骨がんまたは血液がんの治療のための治療薬としてのホスファプラチン化合物

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Publication number Publication date
EP2177525A1 (en) 2010-04-21
US20110034714A1 (en) 2011-02-10
JPWO2009008345A1 (ja) 2010-09-09

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