WO2009007724A3 - Diagnosis and treatment of abnormal blood conditions - Google Patents

Diagnosis and treatment of abnormal blood conditions Download PDF

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Publication number
WO2009007724A3
WO2009007724A3 PCT/GB2008/002364 GB2008002364W WO2009007724A3 WO 2009007724 A3 WO2009007724 A3 WO 2009007724A3 GB 2008002364 W GB2008002364 W GB 2008002364W WO 2009007724 A3 WO2009007724 A3 WO 2009007724A3
Authority
WO
WIPO (PCT)
Prior art keywords
abnormal blood
treatment
platelet activation
diagnosis
methods
Prior art date
Application number
PCT/GB2008/002364
Other languages
French (fr)
Other versions
WO2009007724A2 (en
Inventor
Willem Ouwehand
Alison Helena Goodall
Original Assignee
Europ Cardiovascular Genetics
Willem Ouwehand
Alison Helena Goodall
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Europ Cardiovascular Genetics, Willem Ouwehand, Alison Helena Goodall filed Critical Europ Cardiovascular Genetics
Publication of WO2009007724A2 publication Critical patent/WO2009007724A2/en
Publication of WO2009007724A3 publication Critical patent/WO2009007724A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Biophysics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Methods for diagnosing whether a subject has, or is at risk of, an abnormal blood condition are described. The methods comprise determining the expression level of a gene specifically associated with adenosine-di-phosphate (ADP)-stimulated platelet activation, collagen-related peptide (CRP)-stimulated platelet activation, or ADP- and CRP-stimulated platelet activation in a biological sample obtained from the subject. Methods for identifying potential therapeutic agents for the treatment of abnormal blood conditions are also described.
PCT/GB2008/002364 2007-07-10 2008-07-10 Diagnosis and treatment of abnormal blood conditions WO2009007724A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0713363.0 2007-07-10
GBGB0713363.0A GB0713363D0 (en) 2007-07-10 2007-07-10 Diagnosis and treatment of abnormal blood conditions

Publications (2)

Publication Number Publication Date
WO2009007724A2 WO2009007724A2 (en) 2009-01-15
WO2009007724A3 true WO2009007724A3 (en) 2009-03-26

Family

ID=38461326

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2008/002364 WO2009007724A2 (en) 2007-07-10 2008-07-10 Diagnosis and treatment of abnormal blood conditions

Country Status (2)

Country Link
GB (1) GB0713363D0 (en)
WO (1) WO2009007724A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112877418A (en) * 2021-01-11 2021-06-01 丰能医药科技（上海）有限责任公司 Product for detecting vascular permeability and preparation method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040067903A1 (en) * 2000-08-02 2004-04-08 Alison Williams-Gagnon Nucleic acids encoding a novel regulator of g protein signaling, rgs18, and uses thereof
US20040170624A1 (en) * 2001-01-23 2004-09-02 Bernhard Nieswandt Medicament for the protection against thrombotic diseases

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040067903A1 (en) * 2000-08-02 2004-04-08 Alison Williams-Gagnon Nucleic acids encoding a novel regulator of g protein signaling, rgs18, and uses thereof
US20040170624A1 (en) * 2001-01-23 2004-09-02 Bernhard Nieswandt Medicament for the protection against thrombotic diseases

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
GNATENKO DMITRI V ET AL: "Recent advances in platelet transcriptomics", TRANSFUSION MEDICINE AND HEMOTHERAPY, vol. 33, no. 3, June 2006 (2006-06-01), pages 217 - 226, XP009105658, ISSN: 1660-3796 *
GOH SUNG-HO ET AL: "The human reticulocyte transcriptome.", PHYSIOLOGICAL GENOMICS 18 JUL 2007, vol. 30, no. 2, 3 April 2007 (2007-04-03), pages 172 - 178, XP002497968, ISSN: 1531-2267, Retrieved from the Internet <URL:03-04-2007> [retrieved on 20070403] *
HECHLER B ET AL: "Lineage-specific overexpression of the P2Y1 receptor induces platelet hyper-reactivity in transgenic mice", JOURNAL OF THROMBOSIS AND HAEMOSTASIS, BLACKWELL PUBLISHING, OXFORD, GB, vol. 1, no. 1, 3 January 2003 (2003-01-03), pages 155 - 163, XP009105619, ISSN: 1538-7933 *
HILLMANN A G ET AL: "Comparative RNA expression analyses from small-scale, single-donor platelet samples.", JOURNAL OF THROMBOSIS AND HAEMOSTASIS : JTH FEB 2006, vol. 4, no. 2, February 2006 (2006-02-01), pages 349 - 356, XP009105673, ISSN: 1538-7933 *
MACAULAY IAIN C ET AL: "Platelet genomics and proteomics in human health and disease.", THE JOURNAL OF CLINICAL INVESTIGATION DEC 2005, vol. 115, no. 12, December 2005 (2005-12-01), pages 3370 - 3377, XP002496665, ISSN: 0021-9738 *
MILLER DAVID T ET AL: "Atherosclerosis: the path from genomics to therapeutics.", JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 17 APR 2007, vol. 49, no. 15, 17 April 2007 (2007-04-17), pages 1589 - 1599, XP002496666, ISSN: 1558-3597 *
OUWEHAND W H: "Platelet genomics and the risk of atherothrombosis", JOURNAL OF THROMBOSIS AND HAEMOSTASIS, BLACKWELL PUBLISHING, OXFORD, GB, vol. 5, no. suppl. 1, 9 July 2007 (2007-07-09), pages 188 - 195, XP009105606, ISSN: 1538-7933, Retrieved from the Internet <URL:2007-07-09> [retrieved on 20070709] *
ROGER SÉVERINE ET AL: "Costimulation of the Gi-coupled ADP receptor and the Gq-coupled TXA2 receptor is required for ERK2 activation in collagen-induced platelet aggregation.", FEBS LETTERS 2 JAN 2004, vol. 556, no. 1-3, 2 January 2004 (2004-01-02), pages 227 - 235, XP004483235, ISSN: 0014-5793 *
WATSON S P ET AL: "Collagen receptor signalling in platelets: extending the role of the ITAM.", IMMUNOLOGY TODAY JUN 1998, vol. 19, no. 6, June 1998 (1998-06-01), pages 260 - 264, XP004121054, ISSN: 0167-5699 *

Also Published As

Publication number Publication date
GB0713363D0 (en) 2007-08-22
WO2009007724A2 (en) 2009-01-15

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