WO2009005871A3 - Novel optical labeling molecules in proteomics and other biological analyses - Google Patents

Novel optical labeling molecules in proteomics and other biological analyses Download PDF

Info

Publication number
WO2009005871A3
WO2009005871A3 PCT/US2008/059963 US2008059963W WO2009005871A3 WO 2009005871 A3 WO2009005871 A3 WO 2009005871A3 US 2008059963 W US2008059963 W US 2008059963W WO 2009005871 A3 WO2009005871 A3 WO 2009005871A3
Authority
WO
WIPO (PCT)
Prior art keywords
proteomics
labeling molecules
optical labeling
novel optical
biological analyses
Prior art date
Application number
PCT/US2008/059963
Other languages
French (fr)
Other versions
WO2009005871A2 (en
Inventor
Edward Dratz
Paul Grieco
Original Assignee
Univ Montana State
Edward Dratz
Paul Grieco
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Montana State, Edward Dratz, Paul Grieco filed Critical Univ Montana State
Priority to CA2720991A priority Critical patent/CA2720991A1/en
Priority to EP08826008A priority patent/EP2164997A4/en
Publication of WO2009005871A2 publication Critical patent/WO2009005871A2/en
Publication of WO2009005871A3 publication Critical patent/WO2009005871A3/en
Priority to US12/578,419 priority patent/US20100252433A1/en
Priority to US14/143,608 priority patent/US20140186875A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/13—Labelling of peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2550/00—Electrophoretic profiling, e.g. for proteome analysis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Indole Compounds (AREA)

Abstract

The invention relates to compositions and methods useful in the labeling and identification of proteins and changes in protein modification. The invention provides for highly soluble optical labeling molecules which are optionally cleavable after separation of mixtures of labeled proteins into components. These optical labeling molecules find utility in a variety of applications, including use in the field of proteomics.
PCT/US2008/059963 2007-04-10 2008-04-10 Novel optical labeling molecules in proteomics and other biological analyses WO2009005871A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA2720991A CA2720991A1 (en) 2007-04-10 2008-04-10 Novel optical labeling molecules in proteomics and other biological analyses
EP08826008A EP2164997A4 (en) 2007-04-10 2008-04-10 Novel optical labeling molecules in proteomics and other biological analyses
US12/578,419 US20100252433A1 (en) 2007-04-10 2009-10-13 Novel optical labeling molecules for proteomics and other biological analyses
US14/143,608 US20140186875A1 (en) 2007-04-10 2013-12-30 Novel optical labeling molecules for proteomics and other biological analysis

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US91105107P 2007-04-10 2007-04-10
US60/911,051 2007-04-10
US91654807P 2007-05-07 2007-05-07
US60/916,548 2007-05-07

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/578,419 Continuation-In-Part US20100252433A1 (en) 2007-04-10 2009-10-13 Novel optical labeling molecules for proteomics and other biological analyses

Publications (2)

Publication Number Publication Date
WO2009005871A2 WO2009005871A2 (en) 2009-01-08
WO2009005871A3 true WO2009005871A3 (en) 2009-05-22

Family

ID=40226739

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/059963 WO2009005871A2 (en) 2007-04-10 2008-04-10 Novel optical labeling molecules in proteomics and other biological analyses

Country Status (3)

Country Link
EP (1) EP2164997A4 (en)
CA (1) CA2720991A1 (en)
WO (1) WO2009005871A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20160102210A (en) 2013-12-27 2016-08-29 노버스 인터내쇼날 인코포레이티드 Ethoxylated surfactants
JP6662631B2 (en) * 2015-12-21 2020-03-11 東友ファインケム株式会社Ｄｏｎｇｗｏｏ Ｆｉｎｅ−Ｃｈｅｍ Ｃｏ．， Ｌｔｄ． Novel compound and colored curable resin composition
US10584306B2 (en) 2017-08-11 2020-03-10 Board Of Regents Of The University Of Oklahoma Surfactant microemulsions
CN111100474B (en) * 2019-12-09 2021-03-23 三峡大学 Synthetic method of cyanine dye and application of cyanine dye as acid-base response fluorescent reagent

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5681821A (en) * 1994-10-18 1997-10-28 Georgia Tech Research Corp. Fluorescent 1-peptidylaminoalkanephosphonate derivatives
US6403807B1 (en) * 1999-07-06 2002-06-11 Surromed, Inc. Bridged fluorescent dyes, their preparation and their use in assays
US20040106153A1 (en) * 2002-07-18 2004-06-03 Montana State University Novel zwitterionic fluorescent dyes for labeling in proteomic and other biological analyses

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7198958B2 (en) * 2001-07-02 2007-04-03 Arctic Diagnostics Oy Method for increasing hydrophilicity of fluorescent label compounds
FR2871464B1 (en) * 2004-06-15 2006-09-08 Centre Nat Rech Scient Cnrse COLLECTIONS OF TRACEABLE COMPOUNDS AND USES THEREOF

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5681821A (en) * 1994-10-18 1997-10-28 Georgia Tech Research Corp. Fluorescent 1-peptidylaminoalkanephosphonate derivatives
US6403807B1 (en) * 1999-07-06 2002-06-11 Surromed, Inc. Bridged fluorescent dyes, their preparation and their use in assays
US20040106153A1 (en) * 2002-07-18 2004-06-03 Montana State University Novel zwitterionic fluorescent dyes for labeling in proteomic and other biological analyses

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2164997A4 *

Also Published As

Publication number Publication date
EP2164997A4 (en) 2011-08-17
WO2009005871A2 (en) 2009-01-08
EP2164997A2 (en) 2010-03-24
CA2720991A1 (en) 2009-01-08

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