WO2009004339A3 - Modulation of reactive oxygen species in the treatment of respiratory infection - Google Patents

Modulation of reactive oxygen species in the treatment of respiratory infection Download PDF

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Publication number
WO2009004339A3
WO2009004339A3 PCT/GB2008/002280 GB2008002280W WO2009004339A3 WO 2009004339 A3 WO2009004339 A3 WO 2009004339A3 GB 2008002280 W GB2008002280 W GB 2008002280W WO 2009004339 A3 WO2009004339 A3 WO 2009004339A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
compositions
relates
oxygen species
reactive oxygen
Prior art date
Application number
PCT/GB2008/002280
Other languages
French (fr)
Other versions
WO2009004339A2 (en
Inventor
Tracy Hussell
Robert Snellgrove
Original Assignee
Imperial Innovations Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Innovations Limited filed Critical Imperial Innovations Limited
Publication of WO2009004339A2 publication Critical patent/WO2009004339A2/en
Publication of WO2009004339A3 publication Critical patent/WO2009004339A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Abstract

The invention relates to therapeutic compositions for use in treating, ameliorating or preventing an infection such as a microbial infection in a subject, comprising a compound modulative of reactive oxygen species level, or CD200 level, or CD200R level, or a combination of two or more of said levels in said subject. The invention also relates to methods of treatment using such compositions. In addition, the invention relates to therapeutic compositions for use in treating, ameliorating or preventing an inflammatory pulmonary infection in a mammalian host having a CD200-CD200R axis comprising a compound modulative of said axis, and to methods of treatment using such compositions. Furthermore, the invention relates to therapeutic compositions for use in treating, ameliorating or preventing a microbial infection and/or pulmonary inflammation in a subject comprising a compound mimetic of superoxide dismutase, and to methods of treatment using such compositions.
PCT/GB2008/002280 2007-07-03 2008-07-03 Compositions and methods relating to manipulation of the myeloid immune compartment during respiratory infection WO2009004339A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95832907P 2007-07-03 2007-07-03
US60/958,329 2007-07-03

Publications (2)

Publication Number Publication Date
WO2009004339A2 WO2009004339A2 (en) 2009-01-08
WO2009004339A3 true WO2009004339A3 (en) 2009-10-22

Family

ID=39720324

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2008/002280 WO2009004339A2 (en) 2007-07-03 2008-07-03 Compositions and methods relating to manipulation of the myeloid immune compartment during respiratory infection

Country Status (1)

Country Link
WO (1) WO2009004339A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022521428A (en) * 2019-02-25 2022-04-07 ザ・ユニバーシティ・オブ・シカゴ Methods and compositions for treating inflammatory and autoimmune conditions with ECM-affinity peptides linked to anti-inflammatory agents.

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030223991A1 (en) * 2002-03-15 2003-12-04 Cherwinski Holly M. Methods of modulating CD200 receptors
WO2004060295A2 (en) * 2002-12-27 2004-07-22 Schering Corporation Methods of inducing and maintaining immune tolerance
EP1616869A1 (en) * 1999-01-25 2006-01-18 National Jewish Medical and Research Center Substituted porphyrins and their therapeutic use
WO2007084321A2 (en) * 2006-01-12 2007-07-26 Alexion Pharmaceuticals, Inc. Antibodies to ox-2/cd200 and uses thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1616869A1 (en) * 1999-01-25 2006-01-18 National Jewish Medical and Research Center Substituted porphyrins and their therapeutic use
US20030223991A1 (en) * 2002-03-15 2003-12-04 Cherwinski Holly M. Methods of modulating CD200 receptors
WO2004060295A2 (en) * 2002-12-27 2004-07-22 Schering Corporation Methods of inducing and maintaining immune tolerance
WO2007084321A2 (en) * 2006-01-12 2007-07-26 Alexion Pharmaceuticals, Inc. Antibodies to ox-2/cd200 and uses thereof

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
R. SNELGROVE, E. GWYER, T. HUSSELL: "Modulation of immunity to respiratory viral infection", FUTURE VIROLOGY, vol. 1, no. 4, July 2006 (2006-07-01), pages 471 - 481, XP001538706 *
SNELGROVE ET AL.: "Manipulation of CD200 signalling offers therapeutic potential against respiratory infectious disease", IMMUNOLOGY, vol. 113, 2004, pages 5 - 7, XP002538514 *
SNELGROVE R J ET AL: "In the absence of reactive oxygen species, T cells default to a Th1 phenotype and mediate protection against pulmonary Cryptococcus neoformans infection", JOURNAL OF IMMUNOLOGY 20061015 US, vol. 177, no. 8, 15 October 2006 (2006-10-15), pages 5509 - 5516, XP009105538, ISSN: 0022-1767 *
SNELGROVE ROBERT J ET AL: "A critical function for CD200 in lung immune homeostasis and the severity of influenza infection", NATURE IMMUNOLOGY, NATURE PUBLISHING GROUP, GB, vol. 9, no. 9, 27 July 2008 (2008-07-27), pages 1074 - 1083, XP009105540, ISSN: 1529-2908, [retrieved on 20080727] *
SNELGROVE ROBERT J ET AL: "An absence of reactive oxygen species improves the resolution of lung influenza infection.", EUROPEAN JOURNAL OF IMMUNOLOGY JUN 2006, vol. 36, no. 6, June 2006 (2006-06-01), pages 1364 - 1373, XP002495187, ISSN: 0014-2980 *

Also Published As

Publication number Publication date
WO2009004339A2 (en) 2009-01-08

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