WO2009004058A3 - Novel prolactin compounds - Google Patents

Novel prolactin compounds Download PDF

Info

Publication number
WO2009004058A3
WO2009004058A3 PCT/EP2008/058593 EP2008058593W WO2009004058A3 WO 2009004058 A3 WO2009004058 A3 WO 2009004058A3 EP 2008058593 W EP2008058593 W EP 2008058593W WO 2009004058 A3 WO2009004058 A3 WO 2009004058A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
prolactin
novel
novel prolactin
analogues
Prior art date
Application number
PCT/EP2008/058593
Other languages
French (fr)
Other versions
WO2009004058A2 (en
Inventor
Jens Breinholt
Per Franklin Nielsen
Leif Christensen
Leif Noerskov-Lauritsen
Anders Svensson
Original Assignee
Novo Nordisk As
Jens Breinholt
Per Franklin Nielsen
Leif Christensen
Leif Noerskov-Lauritsen
Anders Svensson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2007/007863 external-priority patent/WO2008028684A2/en
Application filed by Novo Nordisk As, Jens Breinholt, Per Franklin Nielsen, Leif Christensen, Leif Noerskov-Lauritsen, Anders Svensson filed Critical Novo Nordisk As
Priority to EP08802942A priority Critical patent/EP2167059A2/en
Priority to US12/666,395 priority patent/US20100292444A1/en
Publication of WO2009004058A2 publication Critical patent/WO2009004058A2/en
Publication of WO2009004058A3 publication Critical patent/WO2009004058A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57554—Prolactin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Ink Jet (AREA)
  • Detergent Compositions (AREA)

Abstract

The present invention relates to prolactin analogues, which analogues have increased resistance to deamidation.
PCT/EP2008/058593 2007-07-05 2008-07-03 Novel prolactin compounds WO2009004058A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP08802942A EP2167059A2 (en) 2007-07-05 2008-07-03 Novel prolactin compounds
US12/666,395 US20100292444A1 (en) 2007-07-05 2008-07-03 Novel Prolactin Compounds

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
EP07111799 2007-07-05
EP07111799.8 2007-07-05
EPPCT/EP2007/007863 2007-09-10
PCT/EP2007/007863 WO2008028684A2 (en) 2006-09-08 2007-09-10 Peptides with high affinity for the prolactin receptor
EP08388007.0 2008-02-09
EP08388007 2008-02-09
EP08101470.6 2008-02-11
EP08101470 2008-02-11
EP08101589.3 2008-02-13
EP08101589 2008-02-13

Publications (2)

Publication Number Publication Date
WO2009004058A2 WO2009004058A2 (en) 2009-01-08
WO2009004058A3 true WO2009004058A3 (en) 2009-03-12

Family

ID=39971060

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/058593 WO2009004058A2 (en) 2007-07-05 2008-07-03 Novel prolactin compounds

Country Status (2)

Country Link
EP (1) EP2167059A2 (en)
WO (1) WO2009004058A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1464702A1 (en) * 2001-12-28 2004-10-06 Chugai Seiyaku Kabushiki Kaisha Method of stabilizing protein
US20050250689A1 (en) * 2002-12-13 2005-11-10 Brooks Charles L Antagonists for human prolactin

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1464702A1 (en) * 2001-12-28 2004-10-06 Chugai Seiyaku Kabushiki Kaisha Method of stabilizing protein
US20050250689A1 (en) * 2002-12-13 2005-11-10 Brooks Charles L Antagonists for human prolactin

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
HARO L S ET AL: "Secreted mouse prolactin (PRL) and stored ovine PRL. II. Role of amides in receptor binding and immunoreactivity.", ENDOCRINOLOGY JAN 1985, vol. 116, no. 1, January 1985 (1985-01-01), pages 353 - 358, XP009109049, ISSN: 0013-7227 *
LEWIS U J ET AL: "Kinetic study of the deamidation of growth hormone and prolactin", BBA - PROTEIN STRUCTURE, ELSEVIER SCIENCE BV, AMSTERDAM, NL, vol. 214, no. 3, 29 September 1970 (1970-09-29), pages 498 - 508, XP023386313, ISSN: 0005-2795, [retrieved on 19700929] *
ROBINSON N E ET AL: "Structure-dependent nonenzymatic deamidation of glutaminyl and asparaginyl pentapeptides", JOURNAL OF PEPTIDE RESEARCH, vol. 63, no. 5, May 2004 (2004-05-01), pages 426 - 436, XP002504994, ISSN: 1397-002X *
See also references of EP2167059A2 *
SINHA Y N: "Structural variants of prolactin: occurrence and physiological significance.", ENDOCRINE REVIEWS JUN 1995, vol. 16, no. 3, June 1995 (1995-06-01), pages 354 - 369, XP009108998, ISSN: 0163-769X *

Also Published As

Publication number Publication date
EP2167059A2 (en) 2010-03-31
WO2009004058A2 (en) 2009-01-08

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