WO2008154905A3 - Modifications of the histone deacetylase inhibitor suberoylanilide hydroxamic acid - Google Patents

Modifications of the histone deacetylase inhibitor suberoylanilide hydroxamic acid Download PDF

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Publication number
WO2008154905A3
WO2008154905A3 PCT/DE2008/000993 DE2008000993W WO2008154905A3 WO 2008154905 A3 WO2008154905 A3 WO 2008154905A3 DE 2008000993 W DE2008000993 W DE 2008000993W WO 2008154905 A3 WO2008154905 A3 WO 2008154905A3
Authority
WO
WIPO (PCT)
Prior art keywords
histone deacetylase
modifications
hydroxamic acid
deacetylase inhibitor
suberoylanilide hydroxamic
Prior art date
Application number
PCT/DE2008/000993
Other languages
German (de)
French (fr)
Other versions
WO2008154905A2 (en
Inventor
Hans Scheefers
Ursula Scheefers-Borchel
Original Assignee
Schebo Biotech Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE102007028198A external-priority patent/DE102007028198A1/en
Application filed by Schebo Biotech Ag filed Critical Schebo Biotech Ag
Priority to DE112008002230T priority Critical patent/DE112008002230A5/en
Publication of WO2008154905A2 publication Critical patent/WO2008154905A2/en
Publication of WO2008154905A3 publication Critical patent/WO2008154905A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The application relates to compounds of general formula (I) Ar-[CH2]m-Z1-N(Z2-R2)-Z3-[C(O)]r-[CH2]n-Y1-[C(O)]s-Y2-R1, in which the variables can take the values specified in the application. In particularly preferred individual compounds of formula (I), -Z1-N(Z2-R2)-Z3-[C(O)]r- forms an -O-NH-C(O)- or -NH-O-C(O)- group. Said compounds (I) are suitable as medicaments for the treatment of cancer diseases. The effect thereof is due to histone deacetylase inhibition.
PCT/DE2008/000993 2007-06-16 2008-06-16 Modifications of the histone deacetylase inhibitor suberoylanilide hydroxamic acid WO2008154905A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE112008002230T DE112008002230A5 (en) 2007-06-16 2008-06-16 New pharmaceuticals, process for their preparation and their use in medical therapy

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE102007028198.8 2007-06-16
DE102007028198A DE102007028198A1 (en) 2007-06-16 2007-06-16 New alkyl-ketone compounds are histone deacetylase inhibitors, useful to treat e.g. cancer, hematologic or solid tumors, non-Hodgkins tumors, T-cell lymphoma, type I diabetes or Hashimoto's thyroiditis, and to modulate e.g. cell cycle
DE102007037372 2007-08-06
DE102007037372.6 2007-08-06

Publications (2)

Publication Number Publication Date
WO2008154905A2 WO2008154905A2 (en) 2008-12-24
WO2008154905A3 true WO2008154905A3 (en) 2009-08-27

Family

ID=39944377

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2008/000993 WO2008154905A2 (en) 2007-06-16 2008-06-16 Modifications of the histone deacetylase inhibitor suberoylanilide hydroxamic acid

Country Status (2)

Country Link
DE (1) DE112008002230A5 (en)
WO (1) WO2008154905A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102009019852A1 (en) 2009-05-06 2010-11-11 Schebo Biotech Ag New polymer compound comprising amine structural elements, useful as synthetic resins, coatings, foams, liquid crystals, adhesives, paints, varnishes, composite materials, in cosmetics, and in polymer electronics
CN107522654B (en) * 2016-06-21 2020-09-01 中国人民解放军军事医学科学院毒物药物研究所 Novel alpha-aminoamide derivatives and medicinal use thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4018294B1 (en) * 1962-01-30 1965-08-18
US3262978A (en) * 1963-06-19 1966-07-26 Colgate Palmolive Co O-arylamino-and-aralkyl-amino-alkylhydroxyl-amines
WO2001070675A2 (en) * 2000-03-24 2001-09-27 Methylgene, Inc. Inhibitors of histone deacetylase

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4018294B1 (en) * 1962-01-30 1965-08-18
US3262978A (en) * 1963-06-19 1966-07-26 Colgate Palmolive Co O-arylamino-and-aralkyl-amino-alkylhydroxyl-amines
WO2001070675A2 (en) * 2000-03-24 2001-09-27 Methylgene, Inc. Inhibitors of histone deacetylase

Non-Patent Citations (27)

* Cited by examiner, † Cited by third party
Title
"Org. Synth. Coll. Vol. IV", 1963 *
"SMALL MOLECULE INHIBITORS OF HISTONE DEACETYLASE", EXPERT OPIN. THER. PATENTS, vol. 12, no. 6, 1 January 2002 (2002-01-01), pages 943 - 947, XP001120539, ISSN: 1354-3776 *
BIOORG. MED. CHEM., vol. 15, no. 1, 1 January 2007 (2007-01-01), pages 63 - 76 *
CHEM. COMMUN., vol. 3, 1992, pages 274 - 275 *
CHEMTECH, vol. 10, 1958, pages 693 - 698 *
DATABASE BEILSTEIN [online] BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; Database accession no. 2721683, 2722080, 2723874, 272628 (BRNs) *
DATABASE BEILSTEIN [online] BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002504399, Database accession no. 2205846 (BRN) *
DATABASE BEILSTEIN [online] BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002504400, Database accession no. 2205845 (BRN) *
DATABASE BEILSTEIN [online] BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002504401, Database accession no. 5332703 (BRN) *
DATABASE BEILSTEIN [online] BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002504402, Database accession no. 129470 (BRN) *
DATABASE BEILSTEIN [online] BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002504403, Database accession no. 7874189 BRN) *
DATABASE BEILSTEIN [online] BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002504404, Database accession no. 2751837 (BRN) *
DATABASE BEILSTEIN [online] BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002504405, Database accession no. 2837833, 2840716, 2837818, 2840833 (BRN's) *
DATABASE BEILSTEIN [online] BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002504406, Database accession no. 3955418, 3955977, 4030972, 4030992 (BRNs) *
DATABASE BEILSTEIN [online] BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002504407, Database accession no. 6986422 (BRN) *
DATABASE BEILSTEIN [online] BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002504408, Database accession no. 10541154, 10550489, 10544261, 10554562 (BRN's) *
DATABASE BEILSTEIN [online] BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002504409, Database accession no. 2982944 (BRN) *
DATABASE BEILSTEIN [online] BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002504410, Database accession no. 7379654 (BRN) *
FARMACO, vol. 42, no. 10, 1987, pages 697 - 708 *
INDIAN J. CHEM., vol. 34, no. 2, 1995, pages 102 - 106 *
J. CHEM. SOC., PERKIN TRANS. 1, 1975, pages 825 - 830 *
J. CHEM. SOC., PERKIN TRANS. 2, 1980, pages 1 - 3 *
J. PHARM. SCI., vol. 61, 1972, pages 1739 - 1745 *
KELLY ET AL.: "HISTONE DEACETYLASE INHIBITORS: FROM TARGET TO CLINICAL TRIALS", EXPERT OPIN. INVESTIG. DRUGS, vol. 11, no. 12, 1 December 2002 (2002-12-01), pages 1695 - 1713, XP001202636, ISSN: 1354-3784 *
ROCZNIKI CHEMII, vol. 41, 1967, pages 493 *
STERNSON ET AL.: "Synthesis of 7200 Small Molecules Based on a Substructural Analysis of the Histone Deacetylase Inhibitors Trichostatin and Trapoxin", ORGANIC LETTERS, AMERICAN CHEMICAL SOCIETY, COLUMBUS, OH; US, vol. 3, no. 26, 1 January 2001 (2001-01-01), pages 4239 - 4242, XP002220922, ISSN: 1523-7060 *
SYNLETT, vol. 3, 1998, pages 301 - 303 *

Also Published As

Publication number Publication date
WO2008154905A2 (en) 2008-12-24
DE112008002230A5 (en) 2010-05-20

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