WO2008154518A3 - Materials and methods for modulating protective pathways in epithelial cells - Google Patents

Materials and methods for modulating protective pathways in epithelial cells Download PDF

Info

Publication number
WO2008154518A3
WO2008154518A3 PCT/US2008/066368 US2008066368W WO2008154518A3 WO 2008154518 A3 WO2008154518 A3 WO 2008154518A3 US 2008066368 W US2008066368 W US 2008066368W WO 2008154518 A3 WO2008154518 A3 WO 2008154518A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
materials
epithelial cells
modulating
activity
Prior art date
Application number
PCT/US2008/066368
Other languages
French (fr)
Other versions
WO2008154518A2 (en
Inventor
Eugene B Chang
Mikihiro Fujiya
Mark W Musch
Original Assignee
Univ Chicago
Eugene B Chang
Mikihiro Fujiya
Mark W Musch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Chicago, Eugene B Chang, Mikihiro Fujiya, Mark W Musch filed Critical Univ Chicago
Publication of WO2008154518A2 publication Critical patent/WO2008154518A2/en
Publication of WO2008154518A3 publication Critical patent/WO2008154518A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/56916—Enterobacteria, e.g. shigella, salmonella, klebsiella, serratia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/06—Gastro-intestinal diseases
    • G01N2800/065—Bowel diseases, e.g. Crohn, ulcerative colitis, IBS

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Food Science & Technology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Physiology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention provides methods for identifying modulators of an activity of a charged oligopeptide transport molecule of a eukaryotic host cell useful in prophylactic and therapeutic treatments of microbial pathogens, such as virulent intestinal bacteria. In related aspects, the invention provides methods for modulating the activity of Heat Shock Protein 27, Akt, p38 MAP Kinase and/or Ragl.
PCT/US2008/066368 2007-06-08 2008-06-09 Materials and methods for modulating protective pathways in epithelial cells WO2008154518A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94294607P 2007-06-08 2007-06-08
US60/942,946 2007-06-08

Publications (2)

Publication Number Publication Date
WO2008154518A2 WO2008154518A2 (en) 2008-12-18
WO2008154518A3 true WO2008154518A3 (en) 2009-02-19

Family

ID=40130470

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/066368 WO2008154518A2 (en) 2007-06-08 2008-06-09 Materials and methods for modulating protective pathways in epithelial cells

Country Status (1)

Country Link
WO (1) WO2008154518A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1399793B1 (en) * 2010-01-12 2013-05-03 Giuliani Spa PROCEDURE FOR THE PREPARATION OF A BIOMASS INCLUDING PLANTARICINA AND ITS USES IN MEDICAL FIELD.
CN112239735B (en) * 2020-09-18 2022-05-24 华中农业大学 Bacillus subtilis, microbial inoculum, screening method and application

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001090309A2 (en) * 2000-05-22 2001-11-29 Colorado State University Research Foundation Peptides that stimulate mycobacterial growth
US20040170995A1 (en) * 2001-02-28 2004-09-02 Phillip Lograsso Isolated nucleic acid molecules encoding a novel human signal transducing kinase-mapkap-2; encoded proteins, cells transformed therewith and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001090309A2 (en) * 2000-05-22 2001-11-29 Colorado State University Research Foundation Peptides that stimulate mycobacterial growth
US20040170995A1 (en) * 2001-02-28 2004-09-02 Phillip Lograsso Isolated nucleic acid molecules encoding a novel human signal transducing kinase-mapkap-2; encoded proteins, cells transformed therewith and uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SAKAMOTO ET AL: "Modulation of Heat-shock Protein 27 (Hsp27) Anti-apoptopic Activity by Methylglyoxal Modification", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 48, pages 45770 - 45775 *

Also Published As

Publication number Publication date
WO2008154518A2 (en) 2008-12-18

Similar Documents

Publication Publication Date Title
WO2007076423A3 (en) INHIBITORS OF Akt ACTIVITY
WO2008098104A8 (en) Inhibitors of akt activity
CY1120257T1 (en) PYROLOL [2,3b] PYRIDIN-4-GLAMES AND PYROLOL [2,3b] PYRIMIDIN-4-GLAMES AS JANUS MODELS
WO2007022030A3 (en) Methods and compositions for the efficient delivery of therapeutic agents to cells and animals
DE60330841D1 (en) OVEREXPRESSION OF EXTREMOCYM GENES IN PSEUDOMONAS AND NEARLY RELATED BACTERIA
WO2010038086A8 (en) P38 map kinase inhibitors
EP2617431A3 (en) Polypeptide inhibitors of HSP27 kinase and uses therefor
WO2006110586A3 (en) Identification of a new class of epsp synthases
WO2003096255A3 (en) Simulation system for medical procedures
WO2008080134A3 (en) 4-amin0-2- (hetero) arylamino-5- (hetero) arylthiazoles useful as axl inhibitors
GB0505970D0 (en) Culture medium containing kinase inhibitor, and uses thereof
EP2043515A4 (en) Spinal access and neural localization
NO20085373L (en) P38 inhibitors, their preparation and use
NO20066050L (en) Substituted indazoles, compositions containing them and their preparation and use
WO2006099610A3 (en) Methods of identifying therapeutic targets for the treatment of vulvovaginal atrophy
WO2008063330A3 (en) Molecular control of brown fat differentiation and energy expenditure
WO2007016674A3 (en) 2-aminoaryl pyridines as protein kinases inhibitors
WO2010034015A3 (en) Modulating the alternative complement pathway
WO2005115431A3 (en) Methods for inhibiting proteasome and heat shock protein 90
WO2008073174A3 (en) Antimicrobial therapy
MY148451A (en) Antibodies against il-25
WO2009114097A3 (en) Method of modulating t cell-dependent immune responses
WO2005103229A3 (en) Transgenomic mitochondria, transmitochondrial cells and organisms, and methods of making and using
WO2007059077A3 (en) Compositions and methods for altering alpha- and beta-tocotrienol content
WO2008040190A8 (en) Small peptides for anti-angiogenesis and use thereof

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08770539

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08770539

Country of ref document: EP

Kind code of ref document: A2