WO2008154030A3 - Multi-phased scaffold for fixation of musculoskeletal soft tissue to bone - Google Patents

Multi-phased scaffold for fixation of musculoskeletal soft tissue to bone Download PDF

Info

Publication number
WO2008154030A3
WO2008154030A3 PCT/US2008/007323 US2008007323W WO2008154030A3 WO 2008154030 A3 WO2008154030 A3 WO 2008154030A3 US 2008007323 W US2008007323 W US 2008007323W WO 2008154030 A3 WO2008154030 A3 WO 2008154030A3
Authority
WO
WIPO (PCT)
Prior art keywords
scaffold
bone
soft tissue
fixation
another example
Prior art date
Application number
PCT/US2008/007323
Other languages
French (fr)
Other versions
WO2008154030A2 (en
Inventor
Helen Lu
Jeffrey Spalazzi
Original Assignee
Univ Columbia
Helen Lu
Jeffrey Spalazzi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Columbia, Helen Lu, Jeffrey Spalazzi filed Critical Univ Columbia
Publication of WO2008154030A2 publication Critical patent/WO2008154030A2/en
Publication of WO2008154030A3 publication Critical patent/WO2008154030A3/en
Priority to US12/455,765 priority Critical patent/US20100047309A1/en
Priority to US12/583,072 priority patent/US8753391B2/en
Priority to US12/806,912 priority patent/US8864843B2/en
Priority to US14/503,053 priority patent/US10265155B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/08—Muscles; Tendons; Ligaments
    • A61F2/0811—Fixation devices for tendons or ligaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/08—Muscles; Tendons; Ligaments
    • A61F2/0811—Fixation devices for tendons or ligaments
    • A61F2002/0847—Mode of fixation of anchor to tendon or ligament
    • A61F2002/087—Anchor integrated into tendons, e.g. bone blocks, integrated rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0051—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in tissue ingrowth capacity, e.g. made from both ingrowth-promoting and ingrowth-preventing parts

Abstract

Scaffold apparatuses are provided for musculoskeletal tissue engineering. In one example, a scaffold apparatus can be configured as an interference screw comprising multiple phases for fixing musculoskeletal soft tissue to bone. In another example, a degradable cell barrier is inserted between adjacent phases of the scaffold apparatus. In another example, the scaffold apparatus, is coupled to a synthetic graft for a ligament. In another example, the scaffold apparatus can comprise a graft collar and a polymer-fiber mesh, and the polymer-fiber mesh applies compressive mechanical loading to the graft collar.
PCT/US2008/007323 2006-12-06 2008-06-11 Multi-phased scaffold for fixation of musculoskeletal soft tissue to bone WO2008154030A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US12/455,765 US20100047309A1 (en) 2006-12-06 2009-06-06 Graft collar and scaffold apparatuses for musculoskeletal tissue engineering and related methods
US12/583,072 US8753391B2 (en) 2007-02-12 2009-08-12 Fully synthetic implantable multi-phased scaffold
US12/806,912 US8864843B2 (en) 2007-02-12 2010-08-24 Biomimmetic nanofiber scaffold for soft tissue and soft tissue-to-bone repair, augmentation and replacement
US14/503,053 US10265155B2 (en) 2007-02-12 2014-09-30 Biomimmetic nanofiber scaffold for soft tissue and soft tissue-to-bone repair, augmentation and replacement

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93419807P 2007-06-11 2007-06-11
US60/934,198 2007-06-11

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2007/025127 Continuation-In-Part WO2008070186A2 (en) 2006-12-06 2007-12-06 Scaffold apparatus for promoting tendon-to-bone fixation
PCT/US2008/007357 Continuation-In-Part WO2008154035A1 (en) 2007-02-12 2008-06-11 Fully synthetic implantable mutli-phased scaffold

Related Child Applications (3)

Application Number Title Priority Date Filing Date
PCT/US2008/001889 Continuation-In-Part WO2008100534A2 (en) 2007-02-12 2008-02-12 Biomimetic nanofiber scaffold for soft tissue and soft tissue-to-bone repair, augmentation and replacement
PCT/US2008/010985 Continuation-In-Part WO2009038808A1 (en) 2006-12-06 2008-09-22 Graft collar system for inducing formation of fibrocartilage and related methods
US12/583,072 Continuation-In-Part US8753391B2 (en) 2007-02-12 2009-08-12 Fully synthetic implantable multi-phased scaffold

Publications (2)

Publication Number Publication Date
WO2008154030A2 WO2008154030A2 (en) 2008-12-18
WO2008154030A3 true WO2008154030A3 (en) 2009-02-26

Family

ID=40130417

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/007323 WO2008154030A2 (en) 2006-12-06 2008-06-11 Multi-phased scaffold for fixation of musculoskeletal soft tissue to bone

Country Status (1)

Country Link
WO (1) WO2008154030A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7767221B2 (en) 2004-03-05 2010-08-03 The Trustees Of Columbia University In The City Of New York Multi-phased, biodegradable and osteointegrative composite scaffold for biological fixation of musculoskeletal soft tissue to bone
US8753391B2 (en) 2007-02-12 2014-06-17 The Trustees Of Columbia University In The City Of New York Fully synthetic implantable multi-phased scaffold
US20150290248A1 (en) * 2014-04-10 2015-10-15 Nanofiber Health, Inc. Fibrous component for health, performance, and aesthetic treatment
WO2023161929A1 (en) * 2022-02-24 2023-08-31 Corneat Vision Ltd. Implantable synthetic structures comprising porous polymer

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040010320A1 (en) * 2000-05-11 2004-01-15 Huckle James William Tissue regrafting
US20060204738A1 (en) * 2003-04-17 2006-09-14 Nanosys, Inc. Medical device applications of nanostructured surfaces
US20060273279A1 (en) * 2003-01-07 2006-12-07 Massachusetts Institute Of Technology Electrospun pharmaceutical compositions

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040010320A1 (en) * 2000-05-11 2004-01-15 Huckle James William Tissue regrafting
US20060273279A1 (en) * 2003-01-07 2006-12-07 Massachusetts Institute Of Technology Electrospun pharmaceutical compositions
US20060204738A1 (en) * 2003-04-17 2006-09-14 Nanosys, Inc. Medical device applications of nanostructured surfaces

Also Published As

Publication number Publication date
WO2008154030A2 (en) 2008-12-18

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