WO2008152490A3 - Loaded target-specific vesicles, method of producing the vesicles and their use in medical imaging - Google Patents

Loaded target-specific vesicles, method of producing the vesicles and their use in medical imaging Download PDF

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Publication number
WO2008152490A3
WO2008152490A3 PCT/IB2008/001523 IB2008001523W WO2008152490A3 WO 2008152490 A3 WO2008152490 A3 WO 2008152490A3 IB 2008001523 W IB2008001523 W IB 2008001523W WO 2008152490 A3 WO2008152490 A3 WO 2008152490A3
Authority
WO
WIPO (PCT)
Prior art keywords
vesicles
imaging
medical imaging
producing
targetable
Prior art date
Application number
PCT/IB2008/001523
Other languages
French (fr)
Other versions
WO2008152490A2 (en
Inventor
Pavel Broz
Sergey Driamov
Wolfgang Meier
Patrick Hunziker
Original Assignee
Universität Basel
University Hospital Of Basel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universität Basel, University Hospital Of Basel filed Critical Universität Basel
Publication of WO2008152490A2 publication Critical patent/WO2008152490A2/en
Publication of WO2008152490A3 publication Critical patent/WO2008152490A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1887—Agglomerates, clusters, i.e. more than one (super)(para)magnetic microparticle or nanoparticle are aggregated or entrapped in the same maxtrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents

Abstract

This invention relates to targetable vesicles and targetable vesicle-based contrast agents imaging in clinical medicine including in vitro and in vivo imaging. Enzyme nanoreactors having polymer membranes are used to precipitate highly insoluble nanoparticles inside the vesicles. Surface modification with targeting moieties such as the macrophage scavenger receptor A1 (SRA-1) ligand polyguanylic acid and fluorescence-labeled streptavidin provides bimodal target-specific vesicles providing contrast for medical imaging such as MR and fluorescence imaging.
PCT/IB2008/001523 2007-06-14 2008-06-13 Loaded target-specific vesicles, method of producing the vesicles and their use in medical imaging WO2008152490A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94394907P 2007-06-14 2007-06-14
US60/943,949 2007-06-14

Publications (2)

Publication Number Publication Date
WO2008152490A2 WO2008152490A2 (en) 2008-12-18
WO2008152490A3 true WO2008152490A3 (en) 2010-06-24

Family

ID=39940627

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/001523 WO2008152490A2 (en) 2007-06-14 2008-06-13 Loaded target-specific vesicles, method of producing the vesicles and their use in medical imaging

Country Status (1)

Country Link
WO (1) WO2008152490A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009034458A2 (en) * 2007-09-11 2009-03-19 Universität Basel Oxygen permeable polymeric nanocontainers for encapsulation of sensitive compounds
US20140141089A1 (en) * 2009-02-11 2014-05-22 Colorado School Of Mines Nanoparticles, Compositions Thereof, and Methods of Use, and Methods of Making the Same
US20110201076A1 (en) 2010-01-22 2011-08-18 Colorado School Of Mines Harvesting micro algae
CN104013967B (en) * 2014-04-25 2016-06-15 同济大学 A kind of gadolinium polymer vesicle and its preparation method and application that carries
CN107567330A (en) 2014-12-23 2018-01-09 巴塞尔大学医院 Amphipathic nature polyalcohol system
CN109125744B (en) * 2018-08-24 2021-04-23 浙江大学 Preparation method of gadolinium-doped hafnium oxide nanoparticles with MRI and CT bimodal imaging functions
CN109364245B (en) * 2018-09-04 2021-06-25 中山大学 Polydopamine nano diagnosis and treatment agent and preparation method thereof
EP4087927A4 (en) 2020-01-09 2024-01-24 Ensovi Inc Artificial organelles for enzymatic cofactor reduction

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001032146A2 (en) * 1999-11-05 2001-05-10 Biocure, Inc. Amphiphilic polymeric vesicles

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001032146A2 (en) * 1999-11-05 2001-05-10 Biocure, Inc. Amphiphilic polymeric vesicles

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BROZ P ET AL: "Cell targeting by a generic receptor-targeted polymer nanocontainer platform", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL LNKD- DOI:10.1016/J.JCONREL.2004.10.014, vol. 102, no. 2, 2 February 2005 (2005-02-02), pages 475 - 488, XP004710972, ISSN: 0168-3659 *
BROZ PAVEL ET AL: "Toward intelligent nanosize bioreactors: a pH-switchable, channel-equipped, functional polymer nanocontainer. Supporting information", NANOLETTERS, vol. 6, no. 10, October 2006 (2006-10-01), DOI: http://pubs.acs.org/doi/suppl/10.1021/nl0619305/suppl_file/nl061 *
BROZ PAVEL ET AL: "Toward intelligent nanosize bioreactors: a pH-switchable, channel-equipped, functional polymer nanocontainer.", NANO LETTERS OCT 2006 LNKD- PUBMED:17034109, vol. 6, no. 10, October 2006 (2006-10-01), pages 2349 - 2353, XP002577205, ISSN: 1530-6984 *
INVITROGEN CORPORATION: "ELFŸ 97 Endogenous Phosphatase Detection Kit (Cat. n° E6601)", XP002577206, Retrieved from the Internet <URL:HTTP://WWW.INVITROGEN.COM/SITE/US/EN/HOME/SUPPORT/PRODUCT-TECHNICAL-RESOURCES/PRODUCT-STRUCTURES.-06601.HTML> [retrieved on 201004] *
SAUER M ET AL: "Ion-carrier controlled precipitation of calcium phosphate in giant ABA triblock copolymer vesicles", CHEMICAL COMMUNICATIONS 20011207 GB, no. 23, 7 December 2001 (2001-12-07), pages 2452 - 2453, XP002577207, ISSN: 1359-7345 *

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Publication number Publication date
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