WO2008152475A3 - Biocompatible polymers of bisacrylamides and amino acids - Google Patents

Biocompatible polymers of bisacrylamides and amino acids Download PDF

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Publication number
WO2008152475A3
WO2008152475A3 PCT/IB2008/001495 IB2008001495W WO2008152475A3 WO 2008152475 A3 WO2008152475 A3 WO 2008152475A3 IB 2008001495 W IB2008001495 W IB 2008001495W WO 2008152475 A3 WO2008152475 A3 WO 2008152475A3
Authority
WO
WIPO (PCT)
Prior art keywords
bisacrylamides
amino acids
biocompatible polymers
group
peptide
Prior art date
Application number
PCT/IB2008/001495
Other languages
French (fr)
Other versions
WO2008152475A2 (en
Inventor
Paolo Ferruti
Roberta Cavalli
Elisabetta Ranucci
Michele Trotta
Original Assignee
Univ Degli Studi Torino
Paolo Ferruti
Roberta Cavalli
Elisabetta Ranucci
Michele Trotta
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Degli Studi Torino, Paolo Ferruti, Roberta Cavalli, Elisabetta Ranucci, Michele Trotta filed Critical Univ Degli Studi Torino
Publication of WO2008152475A2 publication Critical patent/WO2008152475A2/en
Publication of WO2008152475A3 publication Critical patent/WO2008152475A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/028—Polyamidoamines
    • C08G73/0286—Preparatory process from polyamidoamines and epihalohydrins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0246—Polyamines containing other atoms than carbon, hydrogen, nitrogen or oxygen in the main chain
    • C08G73/0253—Polyamines containing sulfur in the main chain
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0273—Polyamines containing heterocyclic moieties in the main chain
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L79/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing nitrogen with or without oxygen or carbon only, not provided for in groups C08L61/00 - C08L77/00
    • C08L79/02—Polyamines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Materials For Medical Uses (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Polymer formed from monomers obtained by the reaction of a bisacrylamide with at least one amino acid and/or at least one peptide comprising a thiol group and/or a primary amine substituted in position a with an electron-attracting group and a group that is not hydrogen. The monomers preferably have Formula I. The polymer may be used to prepare a medicament, preferably for the vehiculation of an active ingredient, or with peptide -mimetic functions, or again as an active constituent of biosensors.
PCT/IB2008/001495 2007-06-12 2008-06-11 Biocompatible polymers of bisacrylamides and amino acids WO2008152475A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITTO20070415 ITTO20070415A1 (en) 2007-06-12 2007-06-12 BIOCOMPATIBLE POLYMERS OF BISACRYLAMIDS AND AMINO ACIDS
ITTO2007A000415 2007-06-12

Publications (2)

Publication Number Publication Date
WO2008152475A2 WO2008152475A2 (en) 2008-12-18
WO2008152475A3 true WO2008152475A3 (en) 2009-03-19

Family

ID=40129051

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/001495 WO2008152475A2 (en) 2007-06-12 2008-06-11 Biocompatible polymers of bisacrylamides and amino acids

Country Status (2)

Country Link
IT (1) ITTO20070415A1 (en)
WO (1) WO2008152475A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5292840A (en) * 1987-03-13 1994-03-08 Minnesota Mining And Manufacturing Company Polymeric supports

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5292840A (en) * 1987-03-13 1994-03-08 Minnesota Mining And Manufacturing Company Polymeric supports

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ELISIA EMILITRI, PAOLO FERRUTI, RITA ANNUNZIATA, ELISABETTA RANUCCI: "Novel Amphoteric Cystine-Based Poly(amidoamine)s Reponsive to Redox Stimuli", MACROMOLECULES, vol. 40, no. 14, 14 June 2007 (2007-06-14), pages 4785 - 4793, XP002508959 *

Also Published As

Publication number Publication date
ITTO20070415A1 (en) 2008-12-13
WO2008152475A2 (en) 2008-12-18

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