WO2008152423A3 - Treatment of inflammation or autoimmune diseases with sulphated compounds - Google Patents
Treatment of inflammation or autoimmune diseases with sulphated compounds Download PDFInfo
- Publication number
- WO2008152423A3 WO2008152423A3 PCT/GB2008/050437 GB2008050437W WO2008152423A3 WO 2008152423 A3 WO2008152423 A3 WO 2008152423A3 GB 2008050437 W GB2008050437 W GB 2008050437W WO 2008152423 A3 WO2008152423 A3 WO 2008152423A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- present
- relates
- dosage forms
- unit dosage
- compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7016—Disaccharides, e.g. lactose, lactulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7024—Esters of saccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The present invention relates to sulphated compounds containing one to twelve monosaccharide subunits, for the treatment or prevention of anon-gastrointestinal disease or conditionby gastrointestinal absorption, wherein none of the monosaccharide subunits is pyranosyl with N-substitution at the 2-position relative to the anomeric carbon of the pyranosyl subunit. The present invention also relates to corresponding methods of treating or preventing anon-gastrointestinal disease or condition. Additionally, the present invention relates to a method of modifying, or testing for a modification in,the level of a cytokine in vivo, ex vivoor in vitro, said method comprising contacting a sulphated compound with a cell, wherein the compound comprises at least one monosaccharide subunit. The present invention also relates to unit dosage forms comprising at least 2.5g of any of the above compounds, to unit dosage forms comprising the molar equivalent of at least 1 g of any of the above compounds in theirfree acid and/or base form, and to unit dosage forms comprising any of the above compounds other than sucralfate.Preferred compounds of the present invention are sucrose octasulphate and sucralfate.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0711139A GB2450087A (en) | 2007-06-11 | 2007-06-11 | Use of sulphated saccharides in the treatment of inflammatory and/or auto-immune diseases |
GB0711139.6 | 2007-06-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008152423A2 WO2008152423A2 (en) | 2008-12-18 |
WO2008152423A3 true WO2008152423A3 (en) | 2009-02-19 |
Family
ID=38319060
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2008/050437 WO2008152423A2 (en) | 2007-06-11 | 2008-06-11 | Treatment of inflammation or autoimmune diseases with sulphated compounds |
Country Status (2)
Country | Link |
---|---|
GB (1) | GB2450087A (en) |
WO (1) | WO2008152423A2 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201000196D0 (en) | 2010-01-07 | 2010-02-24 | Galvez Julian M | Novel combination |
KR101956335B1 (en) * | 2010-12-01 | 2019-03-08 | 디 오스트레일리언 내셔널 유니버시티 | Histone inhibition |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994028020A1 (en) * | 1993-05-18 | 1994-12-08 | Bukh Meditec A/S | A method for the preparation of interferons |
WO1996035700A1 (en) * | 1995-05-10 | 1996-11-14 | Glycomed Incorporated | Saccharopeptides and derivatives thereof |
US5908836A (en) * | 1987-12-21 | 1999-06-01 | Bar-Shalom; Daniel | Protecting skin from radiation damage using sulphated sugars |
WO2006017752A2 (en) * | 2004-08-05 | 2006-02-16 | Ivax Corporation | Sulfated oligosaccharides |
WO2008059003A1 (en) * | 2006-11-14 | 2008-05-22 | Diosamine Development Corporation | Novel compounds |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK505488D0 (en) * | 1987-12-21 | 1988-09-09 | Bar Shalom Daniel | MEDIUM AND USE OF SAME |
IT1226549B (en) * | 1988-07-12 | 1991-01-24 | Resa Farma | PHARMACEUTICAL COMPOSITIONS WITH ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY FOR ORAL USE, EQUIPPED WITH EXCELLENT PALATABILITY AND FREE FROM IRRITATING EFFECTS ON MUCOSES. |
JP3163358B2 (en) * | 1997-02-28 | 2001-05-08 | 経済産業省産業技術総合研究所長 | Sulfated oligosaccharide compounds |
JP2000143686A (en) * | 1997-02-28 | 2000-05-26 | Agency Of Ind Science & Technol | Sulfated oligosaccharide compound |
US20040039042A1 (en) * | 2002-08-23 | 2004-02-26 | Fleming Thomas E. | Method of transdermal drug delivery |
JP4850402B2 (en) * | 2004-10-07 | 2012-01-11 | ロート製薬株式会社 | Oral preparation |
-
2007
- 2007-06-11 GB GB0711139A patent/GB2450087A/en not_active Withdrawn
-
2008
- 2008-06-11 WO PCT/GB2008/050437 patent/WO2008152423A2/en active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5908836A (en) * | 1987-12-21 | 1999-06-01 | Bar-Shalom; Daniel | Protecting skin from radiation damage using sulphated sugars |
WO1994028020A1 (en) * | 1993-05-18 | 1994-12-08 | Bukh Meditec A/S | A method for the preparation of interferons |
WO1996035700A1 (en) * | 1995-05-10 | 1996-11-14 | Glycomed Incorporated | Saccharopeptides and derivatives thereof |
WO2006017752A2 (en) * | 2004-08-05 | 2006-02-16 | Ivax Corporation | Sulfated oligosaccharides |
WO2008059003A1 (en) * | 2006-11-14 | 2008-05-22 | Diosamine Development Corporation | Novel compounds |
Non-Patent Citations (5)
Title |
---|
BURCH R M ET AL: "Sucralfate induces prolifetion of dermal fibroblasts and keratinocytes in culture and granulation tissue formation in full-thickness skin wounds", AGENTS AND ACTIONS, BIRKHAEUSER VERLAG, BASEL, CH, vol. 34, no. 1-2, 1 January 1991 (1991-01-01), pages 229 - 231, XP002962047, ISSN: 0065-4299 * |
CAHALON LIORA ET AL: "Heparin disaccharides inhibit tumor necrosis factor-alpha production by macrophages and arrest immune inflammation in rodents", INTERNATIONAL IMMUNOLOGY, vol. 9, no. 10, 1997, pages 1517 - 1522, XP002504319, ISSN: 0953-8178 * |
EAMLAMNAM K ET AL: "Effects of Aloe vera and sucralfate on gastric microcirculatory changes, cytokine levels and gastric ulcer healing in rats", WORLD JOURNAL OF GASTROENTEROLOGY, WJG PRESS, CN, vol. 12, no. 13, 7 April 2006 (2006-04-07), pages 2034 - 2039, XP008098731, ISSN: 1007-9327 * |
SCHOELL ISABELLA ET AL: "Anti-ulcer treatment during pregnancy induces food allergy in mouse mothers and a Th2-bias in their offspring", FASEB JOURNAL, vol. 21, no. 4, April 2007 (2007-04-01), pages 1264 - 1270, XP002504320, ISSN: 0892-6638 * |
SLOMIANY B L ET AL: "Effect of sucralfate on gastric mucosal inflammatory responses induced by Helicobacter pylori lipopolysaccharide", SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, vol. 33, no. 9, September 1998 (1998-09-01), pages 916 - 922, XP008095949, ISSN: 0036-5521 * |
Also Published As
Publication number | Publication date |
---|---|
GB2450087A (en) | 2008-12-17 |
GB0711139D0 (en) | 2007-07-18 |
WO2008152423A2 (en) | 2008-12-18 |
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