WO2008151197A8 - Tumor-derived endogenous toll-like receptor 4 ligands - Google Patents

Tumor-derived endogenous toll-like receptor 4 ligands Download PDF

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Publication number
WO2008151197A8
WO2008151197A8 PCT/US2008/065672 US2008065672W WO2008151197A8 WO 2008151197 A8 WO2008151197 A8 WO 2008151197A8 US 2008065672 W US2008065672 W US 2008065672W WO 2008151197 A8 WO2008151197 A8 WO 2008151197A8
Authority
WO
WIPO (PCT)
Prior art keywords
ligands
tumor
receptor
derived endogenous
inducing
Prior art date
Application number
PCT/US2008/065672
Other languages
French (fr)
Other versions
WO2008151197A2 (en
WO2008151197A3 (en
Inventor
Gang Zeng
Xiaoli Tian
Original Assignee
Univ California
Gang Zeng
Xiaoli Tian
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California, Gang Zeng, Xiaoli Tian filed Critical Univ California
Publication of WO2008151197A2 publication Critical patent/WO2008151197A2/en
Publication of WO2008151197A3 publication Critical patent/WO2008151197A3/en
Publication of WO2008151197A8 publication Critical patent/WO2008151197A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag

Abstract

Disclosed herein are proteins, compositions and methods for inducing dendritic cell activation, maturation, polarization, and/or filamentous actin rearrangement in immature dendritic cells, inducing immune responses in subjects, targeting or a dendritic cell for phagocytosis or TLR4 signaling, and reversing, inhibiting, or reducing immune suppression by a cancer in a subject.
PCT/US2008/065672 2007-06-04 2008-06-03 Tumor-derived endogenous toll-like receptor 4 ligands WO2008151197A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94171207P 2007-06-04 2007-06-04
US60/941,712 2007-06-04

Publications (3)

Publication Number Publication Date
WO2008151197A2 WO2008151197A2 (en) 2008-12-11
WO2008151197A3 WO2008151197A3 (en) 2009-01-29
WO2008151197A8 true WO2008151197A8 (en) 2009-07-30

Family

ID=40094397

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/065672 WO2008151197A2 (en) 2007-06-04 2008-06-03 Tumor-derived endogenous toll-like receptor 4 ligands

Country Status (1)

Country Link
WO (1) WO2008151197A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2869828B1 (en) * 2012-07-09 2018-01-03 The Regents of The University of California Vault immunotherapy
CN105555756B (en) * 2013-06-28 2018-12-07 奥克兰联合服务有限公司 Amino acid conjugate and peptide conjugate and conjugation methods
KR20170094449A (en) 2014-12-23 2017-08-17 마가렛 앤 브림블 Amino acid and peptide conjugates and uses thereof
CA3014515A1 (en) 2016-02-26 2017-08-31 Auckland Uniservices Limited Amino acid and peptide conjugates and conjugation process

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6723832B1 (en) * 1996-10-03 2004-04-20 Ludwig Institute For Cancer Research Isolated peptides corresponding to amino acid sequences of NY-ESO-1, which bind to MHC Class I and MHC Class II molecules, and uses thereof

Also Published As

Publication number Publication date
WO2008151197A2 (en) 2008-12-11
WO2008151197A3 (en) 2009-01-29

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