WO2008150074A3 - The composition comprising the extracts, fractions and the isolated compounds of rhus verniciflua for prevention and treatment of diabetic complications - Google Patents

The composition comprising the extracts, fractions and the isolated compounds of rhus verniciflua for prevention and treatment of diabetic complications Download PDF

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Publication number
WO2008150074A3
WO2008150074A3 PCT/KR2008/002806 KR2008002806W WO2008150074A3 WO 2008150074 A3 WO2008150074 A3 WO 2008150074A3 KR 2008002806 W KR2008002806 W KR 2008002806W WO 2008150074 A3 WO2008150074 A3 WO 2008150074A3
Authority
WO
WIPO (PCT)
Prior art keywords
diabetic complications
fractions
extracts
prevention
treatment
Prior art date
Application number
PCT/KR2008/002806
Other languages
French (fr)
Other versions
WO2008150074A2 (en
Inventor
Sang Hoon Jung
Eun Ha Lee
Cheol-Ho Pan
Chul Young Kim
Byung Hun Um
Dong-Un Lee
Dae Geun Song
Joo Young Lee
Original Assignee
Korea Inst Sci & Tech
Sang Hoon Jung
Eun Ha Lee
Cheol-Ho Pan
Chul Young Kim
Byung Hun Um
Dong-Un Lee
Dae Geun Song
Joo Young Lee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Korea Inst Sci & Tech, Sang Hoon Jung, Eun Ha Lee, Cheol-Ho Pan, Chul Young Kim, Byung Hun Um, Dong-Un Lee, Dae Geun Song, Joo Young Lee filed Critical Korea Inst Sci & Tech
Publication of WO2008150074A2 publication Critical patent/WO2008150074A2/en
Publication of WO2008150074A3 publication Critical patent/WO2008150074A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/22—Anacardiaceae (Sumac family), e.g. smoketree, sumac or poison oak
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Organic Chemistry (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention relates to a composition for prevention and treatment of diabetic complications containing the extracts of Rhus verniciflua, fractions thereof and compounds isolated therefrom as an active ingredient, more precisely a composition for prevention and treatment of diabetic complications which comprises the extracts of Rhus verniciflua extracted by using water, alcohol or a mixture thereof as a solvent, fractions thereof and compounds isolated therefrom as an active ingredient. The extracts of Rhus verniciflua extracted by- using water, alcohol or a mixture thereof as a solvent, fractions thereof and compounds isolated therefrom were confirmed to have inhibitory effect on aldose reductase causing accumulation of sorbitol which is one of major causes of diabetic complications and on advanced glycation end procuct without cytotoxicity, so that they were confirmed to be safe materials effectively used for the composition for prevention and treatment of diabetic complications.
PCT/KR2008/002806 2007-06-05 2008-05-20 The composition comprising the extracts, fractions and the isolated compounds of rhus verniciflua for prevention and treatment of diabetic complications WO2008150074A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020070054855A KR100926454B1 (en) 2007-06-05 2007-06-05 The composition comprising the extracts, fractions and the isolated compounds of Rhus verniciflua for prevention and treatment of diabetic complications
KR10-2007-0054855 2007-06-05

Publications (2)

Publication Number Publication Date
WO2008150074A2 WO2008150074A2 (en) 2008-12-11
WO2008150074A3 true WO2008150074A3 (en) 2009-01-29

Family

ID=40094293

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2008/002806 WO2008150074A2 (en) 2007-06-05 2008-05-20 The composition comprising the extracts, fractions and the isolated compounds of rhus verniciflua for prevention and treatment of diabetic complications

Country Status (2)

Country Link
KR (1) KR100926454B1 (en)
WO (1) WO2008150074A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102603685A (en) * 2011-01-19 2012-07-25 中国药科大学 Flavonoid fatty acid ester derivatives, preparation method and medicinal use of flavonoid fatty acid ester derivatives
WO2014185601A1 (en) * 2013-05-16 2014-11-20 (주)생명의나무 Pharmaceutical composition for preventing or treating menopausal symptoms containing flavonoid compound derived from toxicodendron vernicifluum extract as active ingredient
CN105837540B (en) * 2016-03-18 2018-06-15 中国林业科学研究院林产化学工业研究所 Method of the extraction with the sulphuretin and butein for inhibiting tyrosinase activity from lacquer tree wood powder
JP7434154B2 (en) * 2017-11-24 2024-02-20 オタゴ イノベーション リミテッド Pharmaceutical combinations and methods for treating diabetes and related diseases
KR102216212B1 (en) * 2019-09-02 2021-02-17 박무순 Pharmaceutical composition comprising the fermentation product and powder of medicinal or edible natural products as an effective component for prevention or treatment of diabetes and health functional food comprising the same

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6413019A (en) * 1987-06-09 1989-01-17 Tsumura & Co Aldose reductase inhibitor
JPH09241165A (en) * 1996-03-04 1997-09-16 Snow Brand Milk Prod Co Ltd Suppressant for maillard reaction
JPH11130671A (en) * 1997-10-28 1999-05-18 Snow Brand Milk Prod Co Ltd Aldose reductase inhibitor
KR100377514B1 (en) * 2000-05-23 2003-03-26 신국현 Chalcone derivatives, method for preparation thereof and pharmaceutical composition containing the said derivatives

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6413019A (en) * 1987-06-09 1989-01-17 Tsumura & Co Aldose reductase inhibitor
JPH09241165A (en) * 1996-03-04 1997-09-16 Snow Brand Milk Prod Co Ltd Suppressant for maillard reaction
JPH11130671A (en) * 1997-10-28 1999-05-18 Snow Brand Milk Prod Co Ltd Aldose reductase inhibitor
KR100377514B1 (en) * 2000-05-23 2003-03-26 신국현 Chalcone derivatives, method for preparation thereof and pharmaceutical composition containing the said derivatives

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JEON W.K. ET AL.: "Anti-platelet effcts of bioactive compounds isolated from the bark of Rhus verniciflua Stokes", JOURNAL OF ETHNOPHARMACOLOGY, vol. 106, 2006, pages 62 - 69 *
JUNG C.H. ET AL.: "Rhus verniciflua Stokes Extract: Radical Scavenging Activities and Protective Effects on H2O2-induced Cytotoxicity in Macrophage RAW 264.7 Cell Lines", BIOLOGICAL & PHARMACEUTICAL BULLETIN, vol. 29, no. 8, 2006, pages 1603 - 1607 *
OSAWA T. ET AL.: "Protective Role of Antioxidative Food Factors in Oxidative Stress Caused by Hyperglycemia", ANNALS OF THE NEW YORK ACADEMY SCIENCES, vol. 1043, 2006, pages 440 - 451 *
YAMAGISHI S. ET AL.: "Molecular mechanism of diabetic retinopathy: role of advanced glycation end products (AGEs) and their receptor (RAGE) in the pathogenesis of diabetic retinopathy", NIPPON GANKA GAKKAI ZASSHI, vol. 109, no. 6, 2005, pages 338 - 345 *

Also Published As

Publication number Publication date
WO2008150074A2 (en) 2008-12-11
KR100926454B1 (en) 2009-11-13
KR20080107049A (en) 2008-12-10

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