WO2008149526A1 - 新規な糖鎖修飾ハプトグロビン - Google Patents

新規な糖鎖修飾ハプトグロビン Download PDF

Info

Publication number
WO2008149526A1
WO2008149526A1 PCT/JP2008/001357 JP2008001357W WO2008149526A1 WO 2008149526 A1 WO2008149526 A1 WO 2008149526A1 JP 2008001357 W JP2008001357 W JP 2008001357W WO 2008149526 A1 WO2008149526 A1 WO 2008149526A1
Authority
WO
WIPO (PCT)
Prior art keywords
formula
amino acid
structure represented
sugar chain
haptoglobin
Prior art date
Application number
PCT/JP2008/001357
Other languages
English (en)
French (fr)
Inventor
Yasuyuki Igarashi
Tsutomu Fujimura
Kimie Murayama
Seiichi Saito
Yoichi Arai
Original Assignee
National University Corporation Hokkaido University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National University Corporation Hokkaido University filed Critical National University Corporation Hokkaido University
Publication of WO2008149526A1 publication Critical patent/WO2008149526A1/ja

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57434—Specifically defined cancers of prostate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)

Abstract

　前立腺癌マーカーとなる前立腺特異的抗原、当該抗原を特異的に認識する抗体、当該前立腺癌マーカーを検体中に検出する方法を提供する。 本発明は、配列番号１に示されるアミノ酸配列又は当該アミノ酸配列においてＮ－グリコシル化部位を除く１ないし数個のアミノ酸が欠失、置換若しくは付加したアミノ酸配列からなり、式３で示される構造を有する糖鎖及び／又は式４で示される構造を有する糖鎖が結合したハプトグロビン、又は前記ハプトグロビン由来のペプチド断片であって式３で示される構造を有する糖鎖及び／又は式４で示される構造を有する糖鎖が結合した前記ペプチド断片に関する。
PCT/JP2008/001357 2007-05-29 2008-05-29 新規な糖鎖修飾ハプトグロビン WO2008149526A1 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93233207P 2007-05-29 2007-05-29
US60/932,332 2007-05-29

Publications (1)

Publication Number Publication Date
WO2008149526A1 true WO2008149526A1 (ja) 2008-12-11

Family

ID=40093358

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/001357 WO2008149526A1 (ja) 2007-05-29 2008-05-29 新規な糖鎖修飾ハプトグロビン

Country Status (1)

Country Link
WO (1) WO2008149526A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009168470A (ja) * 2008-01-10 2009-07-30 Wako Pure Chem Ind Ltd 膵臓癌マーカーおよび膵臓癌の検査方法
WO2016021729A1 (ja) * 2014-08-08 2016-02-11 国立大学法人北海道大学 グリオーマの診断マーカー、判別方法、診断方法、糖鎖マーカーを検出する方法及び糖鎖マーカー

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005098434A2 (en) * 2004-03-30 2005-10-20 Northern Advancement Center For Science & Technology RM2 ANTIGEN (ß1,4-GALNAC-DISIALYL-LC4) AS PROSTATE CANCER-ASSOCIATED ANTIGEN

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005098434A2 (en) * 2004-03-30 2005-10-20 Northern Advancement Center For Science & Technology RM2 ANTIGEN (ß1,4-GALNAC-DISIALYL-LC4) AS PROSTATE CANCER-ASSOCIATED ANTIGEN

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
FUJIMURA, T. ET AL.: "Glycosylation status of haptoglobin in sera of patients with prostate cancer vs. benign prostate disease or normal subjects", INT.J.CANCER, vol. 122, no. 1, 1 January 2008 (2008-01-01), pages 39 - 49, XP008130068 *
SAITO, S. ET AL.: "Haptoglobin-beta chain defined by monoclonal antibody RM2 as a novel serum marker for prostate cancer", INT.J.CANCER, vol. 123, no. 3, 1 August 2008 (2008-08-01), pages 633 - 640, XP002591282 *
SAITO, S. ET AL.: "RM2 antigen (beta1,4-GalNAc- disialyl-Lc4) as a new marker for prostate cancer", INT.J.CANCER, vol. 115, no. 1, 20 May 2005 (2005-05-20), pages 105 - 113, XP003005162 *
SEIICHI SAITO ET AL.: "Monoclonal Kotai RM2 ni yori Kitei sareru Haptoglobin-beta-sa no Nyoro Johigan Kanja Kessei ni Okeru Hatsugen", THE JAPANESE JOURNAL OF UROLOGY, vol. 99, no. 2, 20 February 2008 (2008-02-20), pages 423 *
SEIICHI SAITO ET AL.: "Saikin ni Okeru Gan Idenshi. Yokusei Idenshi no Kenkyu - Zenritsusengan - Zenritsusengan no Tosa Marker RM2 Kogen (beta1,4-GalNAc-disialyl-Lc4)", BIOTHERAPY, vol. 20, no. 4, 30 July 2006 (2006-07-30), pages 418 - 426 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009168470A (ja) * 2008-01-10 2009-07-30 Wako Pure Chem Ind Ltd 膵臓癌マーカーおよび膵臓癌の検査方法
WO2016021729A1 (ja) * 2014-08-08 2016-02-11 国立大学法人北海道大学 グリオーマの診断マーカー、判別方法、診断方法、糖鎖マーカーを検出する方法及び糖鎖マーカー

Similar Documents

Publication Publication Date Title
MX348154B (es) Anticuerpos de enlace a il-1-beta y fragmentos de los mismos.
WO2005087811A3 (en) Estrogen receptors and methods of use
EA200700136A1 (ru) Анти-cd154-антитела
MX347295B (es) Inmunoglobulinas portadoras y usos de las mismas.
WO2008031577A8 (en) Human anti-folate receptor alpha antibodies and antibody fragments for the radioimmunotherapy of ovarian carcinoma
TWI317811B (ja)
MXPA04008077A (es) Anticuerpos ant-a° y su uso.
WO2009041832A3 (en) Vaccines and vaccine components for inhibition of microbial cells
IL186948A0 (en) Monoclonal antibodies and methods for their use in the detection of cervical disease
EP2292644A3 (en) Small Streptococcus pyogenes antigens and their use
NZ600348A (en) Anti-c5a binding moieties with high blocking activity
CY1115927T1 (el) Αντισωματα εναντιον της κολοβωμενης παραλλαγης ctf-611 του her2
WO2009004822A1 (ja) 抗Muc17抗体
NZ594480A (en) Methods and compositions for diagnosis and treatment of cancer
WO2008005880A3 (en) Antibodies for norovirus
IN2009CN03372A (ja)
WO2008098917A3 (en) Novel antibodies against igf-ir
MX2011008759A (es) Medios y metodos para fabricar neurotoxina altamente pura.
WO2004099242A3 (en) Streptococcus agalactiae antigens i + ii
WO2010092176A3 (en) Nontypable haemophilus influenzae antigens
WO2009065600A3 (en) Means for treating myosin-related diseases
WO2009030770A3 (en) Methods and tools for prognosis of cancer in er- patients
WO2008087224A3 (en) Mutated netrin 4, fragments thereof and uses thereof as drugs
ATE477274T1 (de) Gegen clostridium difficile gerichtete antikörper
WO2004106367A3 (en) Enterococcus antigens

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08763957

Country of ref document: EP

Kind code of ref document: A1

DPE1 Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101)
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08763957

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: JP