WO2008149096A3 - Polymeric microparticles - Google Patents

Polymeric microparticles Download PDF

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Publication number
WO2008149096A3
WO2008149096A3 PCT/GB2008/001926 GB2008001926W WO2008149096A3 WO 2008149096 A3 WO2008149096 A3 WO 2008149096A3 GB 2008001926 W GB2008001926 W GB 2008001926W WO 2008149096 A3 WO2008149096 A3 WO 2008149096A3
Authority
WO
WIPO (PCT)
Prior art keywords
microparticles
polymer
active compound
pharmaceutically active
coated
Prior art date
Application number
PCT/GB2008/001926
Other languages
French (fr)
Other versions
WO2008149096A2 (en
Inventor
Qingguo Xu
Jan Tadeusz Czernuszka
Original Assignee
Isis Innovation
Qingguo Xu
Jan Tadeusz Czernuszka
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Innovation, Qingguo Xu, Jan Tadeusz Czernuszka filed Critical Isis Innovation
Publication of WO2008149096A2 publication Critical patent/WO2008149096A2/en
Publication of WO2008149096A3 publication Critical patent/WO2008149096A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/501—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The invention provides a microparticle which comprises a polymer, an anionic surfactant, and a hydrophilic pharmaceutically active compound encapsulated in said polymer. The invention further provides a coated microparticle comprising (i) a core, which core comprises a polymer, an anionic surfactant, and a hydrophilic pharmaceutically active compound, which pharmaceutically active compound is encapsulated in said polymer; and (ii) an outer layer which comprises calcium phosphate. The invention further relates to processes for producing the microparticles and coated microparticles; substrates, implants, tissue engineering scaffolds and injectable formulations comprising the coated microparticles; and uses of the microparticles, coated microparticles, substrates, implants, tissue engineering scaffolds and injectable formulations as drug delivery agents and in the treatment of conditions such as bone disorders.
PCT/GB2008/001926 2007-06-07 2008-06-06 Polymeric microparticles WO2008149096A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0711007.5 2007-06-07
GB0711007A GB0711007D0 (en) 2007-06-07 2007-06-07 Polymeric microparticles

Publications (2)

Publication Number Publication Date
WO2008149096A2 WO2008149096A2 (en) 2008-12-11
WO2008149096A3 true WO2008149096A3 (en) 2009-04-16

Family

ID=38318953

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2008/001926 WO2008149096A2 (en) 2007-06-07 2008-06-06 Polymeric microparticles

Country Status (2)

Country Link
GB (1) GB0711007D0 (en)
WO (1) WO2008149096A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8685432B2 (en) 2008-03-25 2014-04-01 University Of Utah Research Foundation Controlled release tissue graft combination biomaterials
GB0903810D0 (en) * 2009-03-05 2009-04-22 Regentec Ltd Delivery system
EP2338480A1 (en) * 2009-12-22 2011-06-29 LEK Pharmaceuticals d.d. Coating of particles comprising a pharmaceutically active ingredient with a carbonate salt or phosphate salt
EP2642984B1 (en) 2010-11-24 2017-01-11 Nanyang Technological University Method for encapsulating particles
SG10201509138XA (en) * 2010-11-24 2015-12-30 Univ Nanyang Tech Method for coating particles with calcium phosphate and particles, microparticles and nanoparticles formed thereof
US9180094B2 (en) 2011-10-12 2015-11-10 The Texas A&M University System High porosity materials, scaffolds, and method of making
JP5909796B2 (en) * 2012-03-02 2016-04-27 株式会社サンギ Method for improving water solubility of poorly soluble substances
WO2014123978A2 (en) 2013-02-05 2014-08-14 University Of Utah Research Foundation Implantable devices for bone or joint defects
US10363215B2 (en) 2013-11-08 2019-07-30 The Texas A&M University System Porous microparticles with high loading efficiencies
CN107497376B (en) * 2017-10-20 2020-02-07 南京工程学院 Preparation method of hydrophobic oleophylic polymer composite microspheres
DE102018003770A1 (en) * 2018-05-09 2019-11-14 Forschungszentrum Borstel Nanocontainers for the transport of nonpolar, lipophilic substances such as antibiotics
CN111249533B (en) * 2020-01-09 2021-01-08 中国人民解放军总医院 Composite aperture electrostatic spinning bracket modified by desferrioxamine sustained-release microbubbles and preparation method thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000000177A1 (en) * 1998-06-26 2000-01-06 Isis Innovation Limited Calcium phosphate coated vesicles
EP1044683A1 (en) * 1999-04-15 2000-10-18 Debio Recherche Pharmaceutique S.A. One-step dispersion method for the microencapsulation of water soluble substances
CN1437933A (en) * 2003-03-28 2003-08-27 中国科学院长春应用化学研究所 Method for preparing Rifampiciu microballs covered by degradable high-molecular material
JP2004008837A (en) * 2002-06-03 2004-01-15 Miyazaki Prefecture S/o suspension, s/o/w emulsion, and their manufacturing method
JP2004099442A (en) * 2002-09-04 2004-04-02 Nisshin Pharma Inc Pharmaceutical preparation containing sparingly soluble drug and method for producing the same
US20040208936A1 (en) * 2002-07-22 2004-10-21 Roland Chorin Novel compositions

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000000177A1 (en) * 1998-06-26 2000-01-06 Isis Innovation Limited Calcium phosphate coated vesicles
EP1044683A1 (en) * 1999-04-15 2000-10-18 Debio Recherche Pharmaceutique S.A. One-step dispersion method for the microencapsulation of water soluble substances
JP2004008837A (en) * 2002-06-03 2004-01-15 Miyazaki Prefecture S/o suspension, s/o/w emulsion, and their manufacturing method
US20040208936A1 (en) * 2002-07-22 2004-10-21 Roland Chorin Novel compositions
JP2004099442A (en) * 2002-09-04 2004-04-02 Nisshin Pharma Inc Pharmaceutical preparation containing sparingly soluble drug and method for producing the same
CN1437933A (en) * 2003-03-28 2003-08-27 中国科学院长春应用化学研究所 Method for preparing Rifampiciu microballs covered by degradable high-molecular material

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE CA CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002515640, retrieved from STN Database accession no. 142: 379 434 *
DATABASE CA CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002515641, retrieved from STN Database accession no. 140: 82 274 *
DATABASE WPI Week 200436, Derwent World Patents Index; AN 2004-380501, XP002515642 *
M. STIGTER ET AL.: "Incorporation of different antibiotics into carbonated hydroxyapatite coatings on titanium implants, release and antibiotic efficacy.", JOURNAL OF CONTROLLED RELEASE, vol. 99, 2004, pages 127 - 137, XP002515639 *
U. WEIDENAUER ET AL.: "Microencapsulation of hydrophilic drug substances using biodegradable polyesters. Part I.", J. MICROENCAPSULATION, vol. 20, no. 4, 2003, pages 509 - 524, XP001162189 *

Also Published As

Publication number Publication date
WO2008149096A2 (en) 2008-12-11
GB0711007D0 (en) 2007-07-18

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