WO2008144483A3 - Agents for treating disorders involving modulation of ryanodine receptors - Google Patents

Agents for treating disorders involving modulation of ryanodine receptors Download PDF

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Publication number
WO2008144483A3
WO2008144483A3 PCT/US2008/063857 US2008063857W WO2008144483A3 WO 2008144483 A3 WO2008144483 A3 WO 2008144483A3 US 2008063857 W US2008063857 W US 2008063857W WO 2008144483 A3 WO2008144483 A3 WO 2008144483A3
Authority
WO
WIPO (PCT)
Prior art keywords
agents
treating disorders
disorders involving
ryanodine receptors
involving modulation
Prior art date
Application number
PCT/US2008/063857
Other languages
French (fr)
Other versions
WO2008144483A2 (en
Inventor
Hongwu Gao
Sandro Belvedere
Yael Webb
Donald Landry
Shixian Deng
Zhenzhuang Cheng
Jiaming Yan
Original Assignee
Armgo Pharma, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Armgo Pharma, Inc. filed Critical Armgo Pharma, Inc.
Priority to TW097118419A priority Critical patent/TW200902026A/en
Priority to ARP080102126A priority patent/AR067845A1/en
Publication of WO2008144483A2 publication Critical patent/WO2008144483A2/en
Publication of WO2008144483A3 publication Critical patent/WO2008144483A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)

Abstract

The present invention provides new agents and compounds effective for treating disorders and diseases associated with RyRs, including cardiac, muscular and cognitive disorders and diseases. These agents are derivatives of benzoxazepines, benzodiazepines and benzazapines. More particularly, the invention provides compounds which include derivatives of benzoxazepine, and their enantiomers, diastereomers, tautomers, pharmaceutically acceptable salts, hydrates, solvates, complexes, polymorphs, metabolites, and prodrugs thereof.
PCT/US2008/063857 2007-05-18 2008-05-16 Agents for treating disorders involving modulation of ryanodine receptors WO2008144483A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
TW097118419A TW200902026A (en) 2007-05-18 2008-05-19 Agents for treating disorders involving modulation of ryanodine receptors
ARP080102126A AR067845A1 (en) 2007-05-18 2008-05-19 COMPOUNDS TO TREAT DISORDERS RELATED TO THE MODULATION OF RIANODINE RECEPTORS AND PHARMACEUTICAL COMPOSITION

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93076307P 2007-05-18 2007-05-18
US60/930,763 2007-05-18

Publications (2)

Publication Number Publication Date
WO2008144483A2 WO2008144483A2 (en) 2008-11-27
WO2008144483A3 true WO2008144483A3 (en) 2012-08-16

Family

ID=40122265

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/063857 WO2008144483A2 (en) 2007-05-18 2008-05-16 Agents for treating disorders involving modulation of ryanodine receptors

Country Status (3)

Country Link
AR (1) AR067845A1 (en)
TW (1) TW200902026A (en)
WO (1) WO2008144483A2 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8710045B2 (en) 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
US20090012103A1 (en) 2007-07-05 2009-01-08 Matthew Abelman Substituted heterocyclic compounds
US20100113461A1 (en) 2008-10-29 2010-05-06 Gilead Palo Alto, Inc. Substituted heterocyclic compounds
US20100113514A1 (en) 2008-10-30 2010-05-06 Gilead Palo Alto, Inc. Fused heterocyclic compounds as ion channel modulators
US20100125091A1 (en) 2008-11-14 2010-05-20 Gilead Palo Alto, Inc. Substituted heterocyclic compounds as ion channel modulators
AU2010249790A1 (en) 2009-05-22 2011-12-08 Exelixis, Inc. Benzoxazepines based P13K/mT0R inhibitors against proliferative diseases
WO2010138487A1 (en) * 2009-05-26 2010-12-02 Exelixis, Inc. BENZOXAZEPINES AS INHIBITORS OF PI3K/m TOR AND METHODS OF THEIR USE AND MANUFACTURE
WO2010138490A1 (en) * 2009-05-26 2010-12-02 Exelixis, Inc. Benzoxazepines as inhibitors of mtor and methods of their use and manufacture
ME02847B (en) 2009-07-27 2018-01-20 Gilead Sciences Inc Fused heterocyclic compounds as ion channel modulators
CA2802288C (en) 2010-07-02 2018-08-21 Gilead Sciences, Inc. Triazolopyridinone compounds as ion channel modulators
WO2012019071A1 (en) * 2010-08-06 2012-02-09 The Trustees Of Columbia University In The City Of New York Methods of preventing and treating sarcopenia
NZ617987A (en) 2011-05-10 2016-02-26 Gilead Sciences Inc Fused heterocyclic compounds as sodium channel modulators
NO3175985T3 (en) * 2011-07-01 2018-04-28
AU2015224425B2 (en) * 2011-07-01 2017-02-09 Gilead Sciences, Inc. Fused benzoxazepinones as ion channel modulators
AU2013201608B9 (en) * 2011-07-01 2015-07-23 Gilead Sciences, Inc. Fused benzoxazepinones as ion channel modulators
TWI478908B (en) 2011-07-01 2015-04-01 Gilead Sciences Inc Fused heterocyclic compounds as ion channel modulators
CA2862670A1 (en) * 2012-01-27 2013-08-01 Gilead Sciences, Inc. Combination therapies using late sodium ion channel blockers and potassium ion channel blockers
MX2016008077A (en) * 2013-12-19 2016-10-12 Gilead Sciences Inc Fused heterocyclic compounds as ion channel modulators.
ES2643856B1 (en) 2016-05-24 2018-08-03 Universidad Del Pais Vasco / Euskal Herriko Unibertsitatea Triazoles for the regulation of intracellular calcium homeostasis
EP3564232B1 (en) 2016-12-27 2022-01-26 Riken Bmp-signal-inhibiting compound
WO2022099011A1 (en) 2020-11-06 2022-05-12 Cytokinetics, Inc. Bicyclic 1,4-diazepanones and therapeutic uses thereof
CN116887839A (en) 2021-01-08 2023-10-13 阿姆果制药有限公司 Crystalline forms of lannodine receptor modulator and uses thereof
WO2022246114A2 (en) 2021-05-20 2022-11-24 Armgo Pharma, Inc. Pharmaceutical compositions comprising a ryanodine receptor modulator and uses thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4125538A (en) * 1977-02-04 1978-11-14 Bristol-Myers Company Substituted 5-phenyl-2,3,4,5-tetrahydro-1,4-benzoxazepines
US4592866A (en) * 1982-09-30 1986-06-03 A. H. Robins Company, Inc. Fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur analogs thereof
WO1998047876A1 (en) * 1997-04-24 1998-10-29 Akzo Nobel N.V. Heterocyclic derivatives and their use as antithrombotic agents
US6489322B1 (en) * 1997-05-05 2002-12-03 Astrazeneca Ab Amidine derivatives as inhibitors of nitric oxide synthase
WO2007024717A2 (en) * 2005-08-25 2007-03-01 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryr receptors

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4125538A (en) * 1977-02-04 1978-11-14 Bristol-Myers Company Substituted 5-phenyl-2,3,4,5-tetrahydro-1,4-benzoxazepines
US4592866A (en) * 1982-09-30 1986-06-03 A. H. Robins Company, Inc. Fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur analogs thereof
WO1998047876A1 (en) * 1997-04-24 1998-10-29 Akzo Nobel N.V. Heterocyclic derivatives and their use as antithrombotic agents
US6489322B1 (en) * 1997-05-05 2002-12-03 Astrazeneca Ab Amidine derivatives as inhibitors of nitric oxide synthase
WO2007024717A2 (en) * 2005-08-25 2007-03-01 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryr receptors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ISHICHI Y ET AL: "Novel acetylcholinesterase inhibitor as increasing agent on rhythmic bladder contractions: SAR of 8-{3-[1-(3-fluorobenzyl)piperidin-4-yl]p ropanoyl}-1,2,5,6-tetrahydro-4H-pyrr olo[3,2,1-ij]quinolin-4-one (TAK-802) and related compounds", BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON, GB, vol. 13, no. 6, 15 March 2005 (2005-03-15), pages 1901 - 1911, XP004758992, ISSN: 0968-0896, DOI: 10.1016/J.BMC.2005.01.022 *
PATANI G A ET AL: "BIOISOSTERISM: A RATIONAL APPROACH IN DRUG DESIGN", CHEMICAL REVIEWS, AMERICAN CHEMICAL SOCIETY, US, vol. 96, no. 8, 1 January 1996 (1996-01-01), pages 3147 - 3176, XP000652176, ISSN: 0009-2665, DOI: 10.1021/CR950066Q *

Also Published As

Publication number Publication date
WO2008144483A2 (en) 2008-11-27
AR067845A1 (en) 2009-10-28
TW200902026A (en) 2009-01-16

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