WO2008143739A3 - Parallel batch reactor - Google Patents
Parallel batch reactor Download PDFInfo
- Publication number
- WO2008143739A3 WO2008143739A3 PCT/US2008/004200 US2008004200W WO2008143739A3 WO 2008143739 A3 WO2008143739 A3 WO 2008143739A3 US 2008004200 W US2008004200 W US 2008004200W WO 2008143739 A3 WO2008143739 A3 WO 2008143739A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- reactor vessels
- valve block
- block
- reactor
- vessel
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K27/00—Construction of housing; Use of materials therefor
- F16K27/003—Housing formed from a plurality of the same valve elements
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00281—Individual reactor vessels
- B01J2219/00283—Reactor vessels with top opening
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
- B01J2219/00308—Reactor vessels in a multiple arrangement interchangeably mounted in racks or blocks
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00389—Feeding through valves
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00477—Means for pressurising the reaction vessels
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00479—Means for mixing reactants or products in the reaction vessels
- B01J2219/00481—Means for mixing reactants or products in the reaction vessels by the use of moving stirrers within the reaction vessels
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00495—Means for heating or cooling the reaction vessels
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00585—Parallel processes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00599—Solution-phase processes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00601—High-pressure processes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00686—Automatic
- B01J2219/00689—Automatic using computers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00686—Automatic
- B01J2219/00691—Automatic using robots
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00695—Synthesis control routines, e.g. using computer programs
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00698—Measurement and control of process parameters
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00736—Non-biologic macromolecules, e.g. polymeric compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mechanical Engineering (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Abstract
In one embodiment, a parallel batch reactor for effecting chemical reactions includes a vessel block (24) comprising reactor vessels (32) for receiving components of a reaction and a valve block (23) removably attached to the vessel block. The valve block (22) includes a first plurality of valves (72) in fluid communication with an inlet port for supplying pressurized fluid to the reactor vessels. (32) and configured to fluidically isolate one or more of the reactor vessels from (32) at least one of the other reactor vessels (32) The valve block (22) further includes a second plurality of valves (76) in fluid communication with the reactor vessels for injecting chemical components into the pressurized reactor vessels (32) or sampling chemical components from the pressurized reactor vessels (32) The vessel block (26) and valve block (22) are configured to sustain an operating pressure of at least 15 psig. A stirring assembly (26) may also be present.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08727236A EP2160237A2 (en) | 2007-05-14 | 2008-03-31 | Parallel batch reactor |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/803,348 US20080286170A1 (en) | 2007-05-14 | 2007-05-14 | Parallel batch reactor |
US11/803,349 | 2007-05-14 | ||
US11/803,224 US7655191B2 (en) | 2007-05-14 | 2007-05-14 | Methods for chemical reactions in a parallel batch reactor |
US11/803,224 | 2007-05-14 | ||
US11/803,348 | 2007-05-14 | ||
US11/803,349 US7807109B2 (en) | 2007-05-14 | 2007-05-14 | Parallel batch reactor with pressure monitoring |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008143739A2 WO2008143739A2 (en) | 2008-11-27 |
WO2008143739A3 true WO2008143739A3 (en) | 2009-03-05 |
Family
ID=39637112
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2008/004200 WO2008143739A2 (en) | 2007-05-14 | 2008-03-31 | Parallel batch reactor |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP2160237A2 (en) |
WO (1) | WO2008143739A2 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8746272B2 (en) * | 2011-09-26 | 2014-06-10 | Air Products And Chemicals, Inc. | Solenoid bypass system for continuous operation of pneumatic valve |
JP2023536369A (en) | 2020-07-02 | 2023-08-24 | アバンティウム・テクノロジーズ・ベー・フェー | System for pressurizing parallel batch reactors and method of using such system |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0402018A1 (en) * | 1989-05-31 | 1990-12-12 | Halliburton Company | Pressure control apparatus |
WO2000009255A2 (en) * | 1998-08-13 | 2000-02-24 | Symyx Technologies | Parallel reactor with internal sensing and method of using same |
US6132686A (en) * | 1999-05-28 | 2000-10-17 | Mettler-Toledo Bohdan, Inc. | Pressurized reaction block |
WO2001093998A2 (en) * | 2000-06-03 | 2001-12-13 | Symyx Technologies, Inc. | Parallel semicontinuous or continuous reactors |
EP1256378A2 (en) * | 2001-05-10 | 2002-11-13 | Bayer Ag | Device and method for parallel conducting of experiments |
US20030128626A1 (en) * | 2001-11-20 | 2003-07-10 | Verkerk Udo Hendrick | Apparatus for the addition of a compound or compound mixture to another |
US20040013565A1 (en) * | 2000-10-02 | 2004-01-22 | Bosch Boris E | Array of autoclaves |
US20040151641A1 (en) * | 2000-07-19 | 2004-08-05 | Symyx Technologies, Inc. | High pressure parallel reactor with individually isolatable vessels |
WO2007020864A1 (en) * | 2005-08-17 | 2007-02-22 | Sibata Scientific Technology Ltd. | Organic synthesizer |
-
2008
- 2008-03-31 WO PCT/US2008/004200 patent/WO2008143739A2/en active Application Filing
- 2008-03-31 EP EP08727236A patent/EP2160237A2/en not_active Withdrawn
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0402018A1 (en) * | 1989-05-31 | 1990-12-12 | Halliburton Company | Pressure control apparatus |
WO2000009255A2 (en) * | 1998-08-13 | 2000-02-24 | Symyx Technologies | Parallel reactor with internal sensing and method of using same |
US6132686A (en) * | 1999-05-28 | 2000-10-17 | Mettler-Toledo Bohdan, Inc. | Pressurized reaction block |
WO2001093998A2 (en) * | 2000-06-03 | 2001-12-13 | Symyx Technologies, Inc. | Parallel semicontinuous or continuous reactors |
US20040151641A1 (en) * | 2000-07-19 | 2004-08-05 | Symyx Technologies, Inc. | High pressure parallel reactor with individually isolatable vessels |
US20040013565A1 (en) * | 2000-10-02 | 2004-01-22 | Bosch Boris E | Array of autoclaves |
EP1256378A2 (en) * | 2001-05-10 | 2002-11-13 | Bayer Ag | Device and method for parallel conducting of experiments |
US20030128626A1 (en) * | 2001-11-20 | 2003-07-10 | Verkerk Udo Hendrick | Apparatus for the addition of a compound or compound mixture to another |
WO2007020864A1 (en) * | 2005-08-17 | 2007-02-22 | Sibata Scientific Technology Ltd. | Organic synthesizer |
EP1923132A1 (en) * | 2005-08-17 | 2008-05-21 | Sibata Scientific Technology Ltd. | Organic synthesizer |
Also Published As
Publication number | Publication date |
---|---|
WO2008143739A2 (en) | 2008-11-27 |
EP2160237A2 (en) | 2010-03-10 |
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