WO2008140487A3 - Improved staphylococcal protein a mono- and bispecific antibodies and methods of their use - Google Patents

Improved staphylococcal protein a mono- and bispecific antibodies and methods of their use Download PDF

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Publication number
WO2008140487A3
WO2008140487A3 PCT/US2007/023903 US2007023903W WO2008140487A3 WO 2008140487 A3 WO2008140487 A3 WO 2008140487A3 US 2007023903 W US2007023903 W US 2007023903W WO 2008140487 A3 WO2008140487 A3 WO 2008140487A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
mono
improved
bispecific antibodies
staphylococcal protein
Prior art date
Application number
PCT/US2007/023903
Other languages
French (fr)
Other versions
WO2008140487A2 (en
Inventor
Nehal Mohamed
Original Assignee
Elusys Therapeutics Inc
Nehal Mohamed
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elusys Therapeutics Inc, Nehal Mohamed filed Critical Elusys Therapeutics Inc
Publication of WO2008140487A2 publication Critical patent/WO2008140487A2/en
Publication of WO2008140487A3 publication Critical patent/WO2008140487A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention provides composite antibodies to S. aureus Protein A. The present invention also provides a bispecific molecule comprising an antibody that binds a C3b-like receptor linked to one or more antibodies which bind to S. aureus Protein A. Methods of their use are also included.
PCT/US2007/023903 2006-11-14 2007-11-14 Improved staphylococcal protein a mono- and bispecific antibodies and methods of their use WO2008140487A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85924006P 2006-11-14 2006-11-14
US60/859,240 2006-11-14

Publications (2)

Publication Number Publication Date
WO2008140487A2 WO2008140487A2 (en) 2008-11-20
WO2008140487A3 true WO2008140487A3 (en) 2009-04-30

Family

ID=40002786

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/023903 WO2008140487A2 (en) 2006-11-14 2007-11-14 Improved staphylococcal protein a mono- and bispecific antibodies and methods of their use

Country Status (1)

Country Link
WO (1) WO2008140487A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20170102039A (en) 2009-04-03 2017-09-06 유니버시티 오브 시카고 Compositions and methods related to Protein A (SpA) variants
KR20130093084A (en) 2010-07-02 2013-08-21 더 유니버시티 오브 시카고 Compositions and methods related to protein a(spa) variants
CN103906535B (en) * 2011-08-15 2017-07-14 芝加哥大学 The composition related to the antibody of staphylococcal protein A and method
JP2015502340A (en) 2011-10-27 2015-01-22 エヌケーティー セラピューティクス インコーポレーテッドＮｋｔ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． Humanized antibody against iNKT
US9988439B2 (en) 2011-12-23 2018-06-05 Nicholas B. Lydon Immunoglobulins and variants directed against pathogenic microbes
WO2013096948A1 (en) 2011-12-23 2013-06-27 Lydon Nicholas B Immunoglobulins and variants directed against pathogenic microbes

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004032832A2 (en) * 2002-09-16 2004-04-22 Elusys Therapeutics, Inc. Bispecific molecule comprising an anti-cr1 antibody cross-linked to an antigen-binding antibody fragment
WO2006050291A1 (en) * 2004-10-29 2006-05-11 Elusys Therapeutics, Inc. Use of cr1-binding molecules in clearance and induction of immune responses

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004032832A2 (en) * 2002-09-16 2004-04-22 Elusys Therapeutics, Inc. Bispecific molecule comprising an anti-cr1 antibody cross-linked to an antigen-binding antibody fragment
WO2006050291A1 (en) * 2004-10-29 2006-05-11 Elusys Therapeutics, Inc. Use of cr1-binding molecules in clearance and induction of immune responses

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "B3150 Sigma Monoclonal Anti-Protein A?Biotin antibody produced in mouse clone SPA-27, purified immunoglobulin, buffered aqueous solution", SIGMA-ALDRICH CATALOG PRODUCT DETAIL, XP002512852, Retrieved from the Internet <URL:http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=B3150¦SIGMA&N5=SEARCH_CONCAT_PNO¦BRAND_KEY&F=SPEC> *
GYIMESI E ET AL: "Staphylococcus aureus bound to complement receptor 1 on human erythrocytes by bispecific monoclonal antibodies is phagocytosed by acceptor macrophages", IMMUNOLOGY LETTERS, ELSEVIER BV, NL, vol. 95, no. 2, 1 September 2004 (2004-09-01), pages 185 - 192, XP004573835, ISSN: 0165-2478 *

Also Published As

Publication number Publication date
WO2008140487A2 (en) 2008-11-20

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