WO2008140041A1 - Novel antiphlogistic-analgesic agent - Google Patents

Novel antiphlogistic-analgesic agent Download PDF

Info

Publication number
WO2008140041A1
WO2008140041A1 PCT/JP2008/058631 JP2008058631W WO2008140041A1 WO 2008140041 A1 WO2008140041 A1 WO 2008140041A1 JP 2008058631 W JP2008058631 W JP 2008058631W WO 2008140041 A1 WO2008140041 A1 WO 2008140041A1
Authority
WO
WIPO (PCT)
Prior art keywords
lactalbumin
antiphlogistic
found
analgesic agent
cox
Prior art date
Application number
PCT/JP2008/058631
Other languages
French (fr)
Japanese (ja)
Inventor
Makoto Yamaguchi
Masayuki Uchida
Original Assignee
Meiji Dairies Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Dairies Corporation filed Critical Meiji Dairies Corporation
Priority to CN2008800156559A priority Critical patent/CN101678077B/en
Priority to JP2009514147A priority patent/JP5683106B2/en
Publication of WO2008140041A1 publication Critical patent/WO2008140041A1/en
Priority to HK10108800.1A priority patent/HK1142277A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38—Albumins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/19—Dairy proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Polymers & Plastics (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Mycology (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The object is to provide a novel antiphlogistic-analgesic agent which is highly safe and can be administered over a long period. A study is made on the antiphlogistic-analgesic effect of α-lactalbumin which is one of natural substances contained in foods, and it is found that α-lactalbumin exhibits a cyclooxygenase-2 (COX-2) inhibition activity and a phospholipase-A2 inhibition activity in vitro. In the in vivo test using a carrageenin food edema model, an adjuvant arthritis model and an acetic acid writhing test, it is also found that α-lactalbumin exhibits an anti-inflammatory effect. Further, it is also found that α-lactalbumin inhibits COX-2 more selectively compared to COX-1. Therefore, α-lactalbumin can be used as an antiphlogistic-analgesic agent having few adverse side effects.
PCT/JP2008/058631 2007-05-11 2008-05-09 Novel antiphlogistic-analgesic agent WO2008140041A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CN2008800156559A CN101678077B (en) 2007-05-11 2008-05-09 Novel antiphlogistic-analgesic agent
JP2009514147A JP5683106B2 (en) 2007-05-11 2008-05-09 New anti-inflammatory analgesic
HK10108800.1A HK1142277A1 (en) 2007-05-11 2010-09-16 Novel antiphlogistic-analgesic agent

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007127286 2007-05-11
JP2007-127286 2007-05-11

Publications (1)

Publication Number Publication Date
WO2008140041A1 true WO2008140041A1 (en) 2008-11-20

Family

ID=40002237

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/058631 WO2008140041A1 (en) 2007-05-11 2008-05-09 Novel antiphlogistic-analgesic agent

Country Status (5)

Country Link
JP (2) JP5683106B2 (en)
KR (1) KR20100017708A (en)
CN (1) CN101678077B (en)
HK (1) HK1142277A1 (en)
WO (1) WO2008140041A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016163400A1 (en) * 2015-04-07 2016-10-13 株式会社明治 Hot flash-suppressing agent
CN113876944A (en) * 2021-10-18 2022-01-04 南京京达生物技术有限公司 Preparation method of immunologic adjuvant

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103431276A (en) * 2013-08-31 2013-12-11 山东卫康生物医药科技有限公司 Mixed-grain total-nutrition formulation food for patients with inflammatory bowel diseases
JP2016204356A (en) * 2015-04-23 2016-12-08 株式会社明治 Hepatic fibrogenesis inhibitor
AU2016366635A1 (en) * 2015-12-07 2018-06-21 Benevolentai Cambridge Limited VAP-1 inhibitors for treating pain

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006219458A (en) * 2005-02-14 2006-08-24 Meiji Milk Prod Co Ltd Agent for inhibiting ischemic enteropathy

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4534316B2 (en) * 2000-07-14 2010-09-01 株式会社玄米酵素 Nutritional supplement manufacturing method and nutritional supplement
JP2003088329A (en) * 2001-09-19 2003-03-25 Yamagami Chizuko Analgesic health supplement
US7144590B2 (en) * 2003-01-09 2006-12-05 Lipoprotein Technologies, Inc. Bioactive compositions derived from humulus lupulus
JP4578821B2 (en) * 2004-02-19 2010-11-10 明治乳業株式会社 Pharmaceutical composition for the treatment of nephritis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006219458A (en) * 2005-02-14 2006-08-24 Meiji Milk Prod Co Ltd Agent for inhibiting ischemic enteropathy

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
YAMAGUCHI M.: "Whey Protein Oyobi Whey Peptide no Tokucho to Koensho Sayo", MILK SCIENCE, vol. 54, no. 2, 2005, pages 69 - 70 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016163400A1 (en) * 2015-04-07 2016-10-13 株式会社明治 Hot flash-suppressing agent
JP6038416B1 (en) * 2015-04-07 2016-12-07 株式会社明治 Fire suppression agent
US11147856B2 (en) 2015-04-07 2021-10-19 Meiji Co., Ltd. Hot flash-suppressing agent
CN113876944A (en) * 2021-10-18 2022-01-04 南京京达生物技术有限公司 Preparation method of immunologic adjuvant

Also Published As

Publication number Publication date
JP5797234B2 (en) 2015-10-21
JPWO2008140041A1 (en) 2010-08-05
KR20100017708A (en) 2010-02-16
JP2013241418A (en) 2013-12-05
CN101678077A (en) 2010-03-24
HK1142277A1 (en) 2010-12-03
JP5683106B2 (en) 2015-03-11
CN101678077B (en) 2013-02-20

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최세영 et al. In-vitro Anti-inflammatory Activity of Rubus coreanus Miq. on Nitric Oxide, Cycloxygenase-2, and Tumor Necrosis Production in the Macrophage like Cell Line RAW 264.7 Activated by Lipopolysccharide

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