WO2008139484A3 - New process for the synthesis of loferpramine maleate: a stable salt of loferpramine - Google Patents

New process for the synthesis of loferpramine maleate: a stable salt of loferpramine Download PDF

Info

Publication number
WO2008139484A3
WO2008139484A3 PCT/IN2007/000195 IN2007000195W WO2008139484A3 WO 2008139484 A3 WO2008139484 A3 WO 2008139484A3 IN 2007000195 W IN2007000195 W IN 2007000195W WO 2008139484 A3 WO2008139484 A3 WO 2008139484A3
Authority
WO
WIPO (PCT)
Prior art keywords
loferpramine
maleate
lofepramine
synthesis
stable salt
Prior art date
Application number
PCT/IN2007/000195
Other languages
French (fr)
Other versions
WO2008139484A2 (en
Original Assignee
R. L. Fine Chem
Ramesha, A., R.
Roy, A., K.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by R. L. Fine Chem, Ramesha, A., R., Roy, A., K. filed Critical R. L. Fine Chem
Priority to PCT/IN2007/000195 priority Critical patent/WO2008139484A2/en
Publication of WO2008139484A2 publication Critical patent/WO2008139484A2/en
Publication of WO2008139484A3 publication Critical patent/WO2008139484A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/28—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11

Abstract

This invention relates to a stable salt of Lofepramine and A process for the synthesis of stable Lofepramine maleate comprising; dissolving maleic acid in ethyl acetate by warming and the solution is then filtered hot; adding purified Lofepramine base to the said clear solution of maleic acid and heated upto about 40-60°C; filtering the precipitates of Lofepramine maleate; drying the said precipitates at 45 to 55°C to obtain Lofepramine maleate.
PCT/IN2007/000195 2007-05-16 2007-05-16 New process for the synthesis of loferpramine maleate: a stable salt of loferpramine WO2008139484A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/IN2007/000195 WO2008139484A2 (en) 2007-05-16 2007-05-16 New process for the synthesis of loferpramine maleate: a stable salt of loferpramine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IN2007/000195 WO2008139484A2 (en) 2007-05-16 2007-05-16 New process for the synthesis of loferpramine maleate: a stable salt of loferpramine

Publications (2)

Publication Number Publication Date
WO2008139484A2 WO2008139484A2 (en) 2008-11-20
WO2008139484A3 true WO2008139484A3 (en) 2009-09-24

Family

ID=40002736

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2007/000195 WO2008139484A2 (en) 2007-05-16 2007-05-16 New process for the synthesis of loferpramine maleate: a stable salt of loferpramine

Country Status (1)

Country Link
WO (1) WO2008139484A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11225487B2 (en) 2017-02-17 2022-01-18 Trevena, Inc. 7-membered aza-heterocyclic containing δ-opioid receptor modulating compounds, methods of using and making the same
SG11202103183PA (en) 2018-09-28 2021-04-29 Univ Griffith Agents and methods for modulating pathogen activity
JP2023546729A (en) * 2020-10-27 2023-11-07 トレベナ・インコーポレイテッド Crystalline and amorphous forms of delta opioid modulators

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0575370B1 (en) * 1991-03-13 1996-04-24 SCHULER, Wilhelm Process for the purification of lofepramine by crystallisation
WO2003015699A2 (en) * 2001-08-17 2003-02-27 Epicept Corporation Topical compositions and methods for treating pain

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0575370B1 (en) * 1991-03-13 1996-04-24 SCHULER, Wilhelm Process for the purification of lofepramine by crystallisation
WO2003015699A2 (en) * 2001-08-17 2003-02-27 Epicept Corporation Topical compositions and methods for treating pain

Also Published As

Publication number Publication date
WO2008139484A2 (en) 2008-11-20

Similar Documents

Publication Publication Date Title
TW200505907A (en) Piperidine-benzenesulfonamide derivatives
WO2008010238A3 (en) Antidiabetic azabicyclo [3. 1. 0] hexan compounds
WO2008094992A3 (en) 2-aminopyridine derivatives useful as kinase inhibitors
WO2008130953A3 (en) 2-imin0is0thiaz0le derivatives as cannabinoid receptor ligands
WO2006053039A3 (en) Hydroxybenzoate salts of metanicotine compounds
DE602008001725D1 (en) 1- (1-BENZYLPIPERIDIN-4-YL) BENZIMIDAZOLE-5-CARBOXYLENE DERIVATIVES FOR THE TREATMENT OF DIABETES MELLITUS
WO2011008312A3 (en) Indole and indoline derivatives and methods of use thereof
CN108659000B (en) Heterocyclic compounds and process for preparing the same
WO2009056707A3 (en) Indol-2-one derivatives disubstituted in the 3-position, preparation thereof and therapeutic use thereof
WO2008139484A3 (en) New process for the synthesis of loferpramine maleate: a stable salt of loferpramine
CN102260260A (en) 8-phenyl xanthine compound, preparation method, medicine composition including the compound and purpose thereof
CN104829590B (en) Method for purifying trelagliptin
ATE407126T1 (en) PREPARATION OF (S)-4-FLUOROMETHYL-DIHYDRO-FURAN-2-ONE
WO2009080198A8 (en) Fused cynopryridines and the use thereof
WO2008033935A3 (en) Vinorelbine derivatives
WO2009021943A3 (en) Novel preparation process
CN105646350A (en) Naphthalimide derivative using ester group for modifying amonafide naphthalene ring and preparation method and application of naphthalimide derivative
WO2009056273A3 (en) Dressing composition
ATE518833T1 (en) AMINOARYLSULFONAMIDE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS
WO2008059513A3 (en) Compounds suitable as modulators of hdl
JP5315337B2 (en) Crystalline form of topotecan hydrochloride and method for producing the same
CN103613597A (en) Preparation process of sildenafil citrate
CN101434601B (en) 2-furyl-1H-benzimidazole-4-acidamide type derivative
WO2010079497A3 (en) Novel polymorph of atazanavir sulfate
CN104725294B (en) A kind of new synthetic method of Oxiracetam key intermediate 2- (2,4- dioxo pyrrolidin -1- bases) ethyl acetate

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07790088

Country of ref document: EP

Kind code of ref document: A2

DPE2 Request for preliminary examination filed before expiration of 19th month from priority date (pct application filed from 20040101)
DPE2 Request for preliminary examination filed before expiration of 19th month from priority date (pct application filed from 20040101)
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 07790088

Country of ref document: EP

Kind code of ref document: A2