WO2008138359A1 - Electrolyzed acidic water for sterilization and disinfection ph 2.5+/- 1.5 - Google Patents

Electrolyzed acidic water for sterilization and disinfection ph 2.5+/- 1.5 Download PDF

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Publication number
WO2008138359A1
WO2008138359A1 PCT/EG2008/000007 EG2008000007W WO2008138359A1 WO 2008138359 A1 WO2008138359 A1 WO 2008138359A1 EG 2008000007 W EG2008000007 W EG 2008000007W WO 2008138359 A1 WO2008138359 A1 WO 2008138359A1
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Prior art keywords
water
sterilizing
bacteria
disinfectant
antiseptic
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PCT/EG2008/000007
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French (fr)
Inventor
Magued George Amin
Heba-T-Allah Fekry Kamel
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Magued George Amin
Heba-T-Allah Fekry Kamel
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Publication of WO2008138359A1 publication Critical patent/WO2008138359A1/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/18Liquid substances or solutions comprising solids or dissolved gases
    • A61L2/186Peroxide solutions
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • CCHEMISTRY; METALLURGY
    • C02TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02FTREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F1/00Treatment of water, waste water, or sewage
    • C02F1/72Treatment of water, waste water, or sewage by oxidation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/10Apparatus features
    • A61L2202/11Apparatus for generating biocidal substances, e.g. vaporisers, UV lamps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/20Targets to be treated
    • A61L2202/24Medical instruments, e.g. endoscopes, catheters, sharps
    • CCHEMISTRY; METALLURGY
    • C02TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02FTREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F1/00Treatment of water, waste water, or sewage
    • C02F1/46Treatment of water, waste water, or sewage by electrochemical methods
    • C02F1/461Treatment of water, waste water, or sewage by electrochemical methods by electrolysis
    • CCHEMISTRY; METALLURGY
    • C02TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02FTREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F2103/00Nature of the water, waste water, sewage or sludge to be treated
    • C02F2103/02Non-contaminated water, e.g. for industrial water supply
    • C02F2103/026Treating water for medical or cosmetic purposes
    • CCHEMISTRY; METALLURGY
    • C02TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02FTREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F2103/00Nature of the water, waste water, sewage or sludge to be treated
    • C02F2103/16Nature of the water, waste water, sewage or sludge to be treated from metallurgical processes, i.e. from the production, refining or treatment of metals, e.g. galvanic wastes
    • CCHEMISTRY; METALLURGY
    • C02TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02FTREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F2209/00Controlling or monitoring parameters in water treatment
    • C02F2209/04Oxidation reduction potential [ORP]
    • CCHEMISTRY; METALLURGY
    • C02TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02FTREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F2303/00Specific treatment goals
    • C02F2303/04Disinfection

Definitions

  • 2- Antiseptics present in the market contain chemicals as cetrimide, chlorhexidine gluconate, ethanol.... etc which affects our skin and causes its dryness especially for those who need to use it frequently as doctors, nurses, dentists, patients with chronic infections as bed sores, diabetic foot etc
  • helicobacter pylori bacteria which secretes urease enzyme that dissolves uric acid in the lining of the stomach and creates ammonia. This ammonia neutralizes the strong acid in our digestive organs and changes the environment, enabling the bacteria to live.
  • Hyperoxidized water is better than glutaraldehyde in that :
  • the endoscope is an indispensable piece of medical equipment used for internal examination of the stomach and duodenum. There has always been a risk that any bacteria that live inside the patient's body, including Helicobacter pylori, causing stomach and duodenal ulcers, can attach themselves to the endoscope during use. Therefore, extreme care must be taken in disinfecting the endoscope after each use. Bacteria are often seen on the tip and extractor area.
  • Hyperoxidized water is put through the tip and the extractor of the endoscope. Then we wash it with high alkaline water that dissolves protein, blood and stomach fluids. Then we soak it in hyperoxidized water for 1 Oseconds. Finally, we wash the unit with tap water. The entire cleaning time takes only about five minutes.

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Environmental & Geological Engineering (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hydrology & Water Resources (AREA)
  • Public Health (AREA)
  • Water Supply & Treatment (AREA)
  • Agronomy & Crop Science (AREA)
  • Inorganic Chemistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Electrolyzed acid water with pH 2.5 +/-1.5, ORP +1100, high amount of dissolved oxygen and chlorine used as a safe, environment friendly broad spectrum antimicrobial agent in many fields. It is used safely in agriculture field to kill germs, as disinfectant for all types of food, surfaces, utensils, in hospitals, in dentistry, in endoscopes. It is used as antiseptic for different dermatologic diseases as bed sores, athletes foot, diabetic foot even that which reaches the stage of gangrene, different wounds even deep ones, burns, Eczema, Dermatitis, Skin Rashes, Psoriasis, Acne..., in peptic and duodenal ulcers.

Description

Electrolyzed Acidic Water For Sterilization And Disinfection pH 2.5+/-1.5
Technical Field
Multipurpose Sterilization, Disinfectant and Antiseptic
Background Art
1- Chemical Disinfectants used in agriculture fields
2- Chemical Antiseptics used for wounds and ulcers
3- Disinfectants used for cleaning of surfaces and grounds in hospitals, hotels, homes, restaurants, Etc
4- Disinfectants for vegetables, fruits, meat, fish, etc
5- Sterilizing products
6- Products used for treatment of dermatological diseases
7- Disinfectants used in sterilization of Endoscopes
8- Disinfectants used in sterilization of Dentists' utensils, hands, mouths of patients to protect the dentist and patient against different bacterial and viral infections
Problems in Background Art;
1- In Agriculture field a- Chemical products used as disinfectants and pesticides in agriculture field may affect human health as these chemicals may not be easily washed off the plants especially in case of some fruits and vegetables as peach, strawberry, cabbage, okra,...etc. They also don't taste so good b- Precipitation of these chemical products in the soil will affect the environment c- These chemicals are toxic for the workers and farmers who spray it, thus they have to wear protective garments, thick rain coats, long boots, gloves, protective masks etc while spraying it which makes their work tougher
2- Antiseptics: present in the market contain chemicals as cetrimide, chlorhexidine gluconate, ethanol.... etc which affects our skin and causes its dryness especially for those who need to use it frequently as doctors, nurses, dentists, patients with chronic infections as bed sores, diabetic foot etc
3- Disinfectants used for cleaning of surfaces: in hospitals may not be effective against all types of bacteria and fungi. Besides, they have pungent odor which might disturb patients
4- Disinfectants used in sterilization of food: as vegetables, fruits, meat, fish,.... May leave chemical traces on food and thus affect our health. 5- Disinfectants used in sterilization of utensils may leave some traces on it and thus affects its efficacy.
6- Antiseptics used for treatment of dermatological diseases contains chemicals which might have some side effects on our skin.
7- Frequent use of Adrenocortical hormones and steroids in treatment of severe itchiness and inflammation accompanying dermatitis may cause a reduction in immunity, a lowering of the functions of the adrenal gland, cataract problems and other side effects
8- Too much frequent use of antibiotics in treatment of peptic and duodena ulcers to kill Helicobacter pylori results in emerging of antibiotic resistant strains of Helicobacter pylori.
9- Disinfection of endoscopes by soaking in 2% solution of glutaraldehyde for 20minutes: where it is
• too time consuming especially in larger hospitals where many patients are examined daily
• highly toxic as it is classified as a strong poison.
• It is also expensive.
• It may cause some inflammation or allergic reactions for the staff responsible for disinfection with this chemical.
Disclosure of the Invention
1- Pure water is subject to electrolysis process after adding minute amount of salt, where positive ions are separated from negative ions and positive ions are collected together to produce strong oxidized acidic water with pH= 2.5 +/- 1.5.
2- It also has high oxidation reduction potential (ORP= +1100).
3- A high amount of Chlorine and oxygen is also dissolved in this water
4- How does it work? It works as an oxidizing agent that withdraws electrons from bacteria, fungi and viruses, thus destroying them. Also the high amount of chlorine and oxygen dissolved in that water promote its antimicrobial activity. Thus it has high sterilizing properties and works as strong antiseptic and disinfectant.
Figure imgf000004_0001
Clinical Study on Anti Microbial effect of Acidic Water on Bacteria
Bacteria Count prior to 5 sec 10 sec 30 sec testing
E-CoIi [3.94 mil i<100 <100 <100
Staphylococcus aureaus 42.5 HIiI <100 <100 <100
Streptococcus pyogenes 18.95 mi ,<100 <100 <100
Pseudomonas aeruginosa ; 17.82 mil <100 <100 <100 MRSA [1 1.24 mi ;<100 <100 <100 Salmonella ; 13.80 mil <100 <100 <100 Sporular bacteria ϋ 1.40 mi 7,500 3,100 <100
Testing agency: Food & Drug Safety Center, Japan Bacterial broth: Low pH acidic water = 1 : 100
Sterilization comparison of conventional disinfectant products
Figure imgf000004_0002
Figure imgf000005_0001
E: Effective L: Less Effective N: Not Effective
5- This water is very safe as it is transformed to normal water in few minutes after doing its action , thus it is used in many fields
6- It is non toxic if accidentally ingested
7- It doesn't cause irritation if it comes in contact with eyes accidentally
8- It is used in many fields as:
• Agriculture field to kill germs instead of agricultural chemicals
• Growing plants and vegetables and maintaining Golf courses
• In sterilizing surfaces
• In sterilizing utensils ....etc
• In sterilizing food as vegetables, fruits, meat, fish, ... etc to prevent food poisoning
• In hospitals: for sterilizing ICU, surgery rooms, medical instruments, hands of doctors and nurses.
• In treatment and prophylaxis of different dermatologic diseases
• As a powerful non toxic antiseptic, it can be used to suppress bleeding.
• In treatment of peptic and duodenal ulcers
• As disinfectant for endoscopes
• It is also used by dentists to sterilize their dental instruments, their hands, and to suppress bleeding from patients and prevent infections
How To Use
1- In Agriculture field: To grow plants and vegetables and maintain Golf courses as a substitute for agricultural chemicals which might remain in the soil and become a source of pollution. It is sprayed over different plants, vegetables and fruits to protect and kill germs where it is transformed to ordinary water when it reaches the soil, thus it is non toxic to the soil. Also farmers and workers don't need to wear protective garments, thick rain coats, long boots, gloves, protective masks... etc while spraying it as it is non toxic which makes their work easier.
2- In sterilizing surfaces: by wiping surfaces with it.
3- In sterilizing utensils: by wiping them with it and drying them at once. 4- In sterilizing food: by washing vegetables, fruits, meat, fish,.... Etc with the water thus killing all types of bacteria and fungi protect us from food poisoning
5- In treatment and prophylaxis of different dermatologic diseases: by washing the affected area with electrolyzed acidic water and it is better than chemical antiseptics in treatment of many diseases as bed sores, athletes foot, diabetic foot even that which reaches the stage of gangrene, different wounds even deep ones, burns, Eczema, Dermatitis, Skin Rashes, Psoriasis, Acne... etc.
6- In hospitals: for sterilizing Intensive Care Unit, surgery rooms, medical instruments, hands of doctors and nurses especially before operations.... etc as it has sterilizing activity against all types of bacteria, fungi and viruses even MRSA, HIV and HBV. This is done by wiping the things needed to be sterilized and for metal instruments they need to be dried after wiping with water
7- In Dentistry: It is used by dentists to sterilize their dental instruments and instantly drying them, their hands,....etc to protect themselves and their patients against dental infection by different bacteria, fungi and viruses especially AIDS, HBV, MRSA It is also very effective in accelerating the healing of surgical wound and in arresting the bleeding. It makes it easier to perform surgery.
8- Help in treatment of peptic and duodenal ulcers by washing the ulcer with highly disinfectant hyperoxidized water. This is done as follows.
One of the main causes of the peptic and duodenal ulcer is helicobacter pylori bacteria which secretes urease enzyme that dissolves uric acid in the lining of the stomach and creates ammonia. This ammonia neutralizes the strong acid in our digestive organs and changes the environment, enabling the bacteria to live. The cellular toxins from pylori and ammonia that these bacteria create damage membranes in the body. These agents together with free radicals created by factors in the immune system create ulcers. If you overuse antibiotics, the danger is that antibiotic resistant strains of Helicobacter pylori might emerge. Thus using hyperoxidized water help kills helicobacter without creating resistant bacteria.
9- Hyperoxidized water is used as disinfectant for endoscopes instead of 2% solution of glutaraldehyde:
Hyperoxidized water is better than glutaraldehyde in that :
• It is faster
• Non Toxic
• Less expensive.
• Non sensitizing thus causes no allergic reactions.
• Has immediate disinfectant capabilities against almost all types of bacteria and viruses including Helicobacter pylori, hepatitis B virus and AIDS virus.
• The wear and tear on the equipment is less than with conventional
The endoscope is an indispensable piece of medical equipment used for internal examination of the stomach and duodenum. There has always been a risk that any bacteria that live inside the patient's body, including Helicobacter pylori, causing stomach and duodenal ulcers, can attach themselves to the endoscope during use. Therefore, extreme care must be taken in disinfecting the endoscope after each use. Bacteria are often seen on the tip and extractor area.
Hyperoxidized water is put through the tip and the extractor of the endoscope. Then we wash it with high alkaline water that dissolves protein, blood and stomach fluids. Then we soak it in hyperoxidized water for 1 Oseconds. Finally, we wash the unit with tap water. The entire cleaning time takes only about five minutes.
10- It is non toxic if accidentally ingested.
11- It doesn't cause irritation if it comes in contact with eyes accidentally.

Claims

Claims
1- Pure water is subject to electrolysis process after adding minute amount of salt, where positive ions are separated from negative ions and positive ions are collected together to produce electrolyzed acid water with pH 2.5 +/- 1.5. It has high oxidation reduction potential (ORP= +1 100) and thus works as an oxidizing agent that withdraws electrons from bacteria, fungi and viruses, thus destroying them. It also contains a high amount of chlorine and oxygen dissolved in that water which promote its broad spectrum antimicrobial activity. Thus it has high sterilizing properties and works as strong antiseptic and disinfectant.
2- 100% natural water and it may contain minute amount of salt
3- Completely safe for man, environment and plant as it is quickly transformed into ordinary water as soon as it has done its action
4- Since it is safe it is used in many fields as:
• Agriculture field to kill germs instead of agricultural chemicals by spraying it on the plants with no harm to the plants, the soil and the workers as it is transformed to ordinary water when it reaches the soil
• Growing plants and vegetables and maintaining Golf courses
• In sterilizing surfaces by wiping them with the electrolyzed acid water
• In sterilizing utensils by wiping them with it and drying them at once especially if they are metallic
• In sterilizing food as vegetables, fruits, meat, fish,...etc by washing with the water thus killing all types of bacteria and fungi and prevent food poisoning with no side effects as it is 100% natural water.
• In hospitals: as disinfectant for sterilizing ICU, surgery rooms, medical instruments and as antiseptic for hands of doctors and nurses where it is mild to our skin and doesn't cause any dryness unlike conventional chemical antiseptics.
Very effective in treatment and prophylaxis of different dermatologic diseases as bed sores, athletes foot, diabetic foot even that which reaches the stage of gangrene, different wounds even deep ones, burns, Eczema, Dermatitis, Skin Rashes, Psoriasis, Acne...etc. This can be done by applying to the affected area instead of conventional antiseptics with no side effects.
As a powerful non toxic antiseptic, it can be used to suppress bleeding. • Helps in treatment of peptic and duodenal ulcers as it is very effective against helicobacter pylori bacteria accompanied by ulcers.
• As disinfectant for endoscopes by soaking in it for 10 seconds and then washing with tap water as it has broad spectrum antimicrobial activity, fast, non toxic and less expensive than conventional 2% glutaraldehyde.
• It is also used by dentists to sterilize their dental instruments and their hands to prevent infection especially against serious ones by HIV, HBV viruses and MRSA bacteria. It also helps in suppressing bleeding from patients.
PCT/EG2008/000007 2007-05-13 2008-02-06 Electrolyzed acidic water for sterilization and disinfection ph 2.5+/- 1.5 WO2008138359A1 (en)

Applications Claiming Priority (2)

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EG2007050234 2007-05-13
EG2007050234 2007-05-13

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111995008A (en) * 2020-08-21 2020-11-27 山西转型综改示范区晋中开发区维斯汉医药科技有限公司 Preparation method and application method of electrolyzed water for treating helicobacter pylori infection

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001054704A1 (en) * 2000-01-12 2001-08-02 Novacal Pharmaceuticals, Llc Physiologically balanced, ionized, acidic solution and methodology for use in wound healing
JP2002338417A (en) * 2001-05-14 2002-11-27 Takayuki Yoshikawa Aqueous solution of titanium oxide in electrolytic water having photo catalytic function for processing product
WO2003045446A1 (en) * 2001-10-12 2003-06-05 Radical Waters (Ip) (Pty) Limited Method for the management and/or treatment of microbially contaminated environments and the use of a new class of microbicidal reagents in such management
JP2003321311A (en) * 2002-05-07 2003-11-11 Hoshizaki Electric Co Ltd Plant disease controlling solution

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001054704A1 (en) * 2000-01-12 2001-08-02 Novacal Pharmaceuticals, Llc Physiologically balanced, ionized, acidic solution and methodology for use in wound healing
JP2002338417A (en) * 2001-05-14 2002-11-27 Takayuki Yoshikawa Aqueous solution of titanium oxide in electrolytic water having photo catalytic function for processing product
WO2003045446A1 (en) * 2001-10-12 2003-06-05 Radical Waters (Ip) (Pty) Limited Method for the management and/or treatment of microbially contaminated environments and the use of a new class of microbicidal reagents in such management
JP2003321311A (en) * 2002-05-07 2003-11-11 Hoshizaki Electric Co Ltd Plant disease controlling solution

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111995008A (en) * 2020-08-21 2020-11-27 山西转型综改示范区晋中开发区维斯汉医药科技有限公司 Preparation method and application method of electrolyzed water for treating helicobacter pylori infection

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