WO2008137733A3 - Micellar structures, methods of making micellar structures, methods of imaging, and methods of delivering agents - Google Patents

Micellar structures, methods of making micellar structures, methods of imaging, and methods of delivering agents Download PDF

Info

Publication number
WO2008137733A3
WO2008137733A3 PCT/US2008/062489 US2008062489W WO2008137733A3 WO 2008137733 A3 WO2008137733 A3 WO 2008137733A3 US 2008062489 W US2008062489 W US 2008062489W WO 2008137733 A3 WO2008137733 A3 WO 2008137733A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
micellar structures
imaging
making
delivering agents
Prior art date
Application number
PCT/US2008/062489
Other languages
French (fr)
Other versions
WO2008137733A2 (en
Inventor
Matthew N. Rhyner
Andrew Smith
Shuming Nie
Original Assignee
Emory University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emory University filed Critical Emory University
Publication of WO2008137733A2 publication Critical patent/WO2008137733A2/en
Publication of WO2008137733A3 publication Critical patent/WO2008137733A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0065—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the luminescent/fluorescent agent having itself a special physical form, e.g. gold nanoparticle
    • A61K49/0067—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the luminescent/fluorescent agent having itself a special physical form, e.g. gold nanoparticle quantum dots, fluorescent nanocrystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0076—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion
    • A61K49/0082—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion micelle, e.g. phospholipidic micelle and polymeric micelle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1887—Agglomerates, clusters, i.e. more than one (super)(para)magnetic microparticle or nanoparticle are aggregated or entrapped in the same maxtrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J5/00—Manufacture of articles or shaped materials containing macromolecular substances
    • C08J5/005—Reinforced macromolecular compounds with nanosized materials, e.g. nanoparticles, nanofibres, nanotubes, nanowires, nanorods or nanolayered materials
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2387/00—Characterised by the use of unspecified macromolecular compounds, obtained otherwise than by polymerisation reactions only involving unsaturated carbon-to-carbon bonds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Materials Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Manufacturing & Machinery (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Micellar structures, methods of making micellar structures, methods of imaging (e.g., imaging cancer and diseases and their related biological systems (e.g., proteins, antibodies, and the like associated with the cancer or disease)), methods of delivering therapeutic agents and/or biological compounds, and the like, are provided.
PCT/US2008/062489 2007-05-02 2008-05-02 Micellar structures, methods of making micellar structures, methods of imaging, and methods of delivering agents WO2008137733A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92718107P 2007-05-02 2007-05-02
US60/927,181 2007-05-02

Publications (2)

Publication Number Publication Date
WO2008137733A2 WO2008137733A2 (en) 2008-11-13
WO2008137733A3 true WO2008137733A3 (en) 2011-07-28

Family

ID=39944215

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/062489 WO2008137733A2 (en) 2007-05-02 2008-05-02 Micellar structures, methods of making micellar structures, methods of imaging, and methods of delivering agents

Country Status (1)

Country Link
WO (1) WO2008137733A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010068705A2 (en) * 2008-12-09 2010-06-17 The Regents Of The University Of California Encapsulated agent guided imaging and therapies
GB201010831D0 (en) 2010-06-28 2010-08-11 Ct Angewandte Nanotech Can A micellular combination comprising a nanoparticle and a plurality of surfmer ligands
CN103946148A (en) * 2011-09-27 2014-07-23 俄亥俄州立大学研究基金会 Methods for producing nanoparticles and using the same
WO2017192544A1 (en) 2016-05-02 2017-11-09 Massachusetts Institute Of Technology AMPHIPHILIC NANOPARTICLES FOR CODELIVERY OF WATER-INSOLUBLE SMALL MOLECULES AND RNAi
US20190270932A1 (en) * 2016-11-11 2019-09-05 Merck Patent Gmbh Light luminescent particle
EP3597722A1 (en) * 2018-07-18 2020-01-22 SABIC Global Technologies B.V. An electro-luminescent device-using layer of photo-emissive quantum dots encapsulated into compartmentalized polymeric nano-vesicles
EP3597721A1 (en) * 2018-07-18 2020-01-22 SABIC Global Technologies B.V. Photo-emissive nanoclusters encapsulated in nano-cavities of amphiphilic block copolymer vesicles and methods of their preparation

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040253195A1 (en) * 2001-10-18 2004-12-16 Min-Hyo Seo Polymeric michelle composition with improved stability
US20050158271A1 (en) * 2000-10-11 2005-07-21 Lee Sang C. Pharmaceutical applications of hydrotropic polymer micelles
EP1666031A1 (en) * 2003-09-04 2006-06-07 NanoCarrier Co., Ltd. Composition containing nanoparticles containing water-soluble basic drug encapsulated therein

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050158271A1 (en) * 2000-10-11 2005-07-21 Lee Sang C. Pharmaceutical applications of hydrotropic polymer micelles
US20040253195A1 (en) * 2001-10-18 2004-12-16 Min-Hyo Seo Polymeric michelle composition with improved stability
EP1666031A1 (en) * 2003-09-04 2006-06-07 NanoCarrier Co., Ltd. Composition containing nanoparticles containing water-soluble basic drug encapsulated therein

Also Published As

Publication number Publication date
WO2008137733A2 (en) 2008-11-13

Similar Documents

Publication Publication Date Title
WO2007007173A3 (en) Human anti-madcam antibodies
WO2011157741A3 (en) Human antibody drug conjugates against tissue factor
WO2008137733A3 (en) Micellar structures, methods of making micellar structures, methods of imaging, and methods of delivering agents
WO2008100805A3 (en) Anti-robo4 antibodies and uses therefor
WO2005113747A3 (en) Multicellular tissue and organ culture systems
WO2007038459A3 (en) Carboxyamine compounds and their use in the treatment of hdac dependent diseases
WO2006079120A3 (en) Fc-fusion constructs binding to phosphatidylserine and their therapeutic use
EP4279140A3 (en) Human antibodies against tissue factor
WO2007008463A3 (en) Anti-ctla-4 antibody and cpg-motif-containing synthetic oligodeoxynucleotide combination therapy for cancer treatment
WO2005103081A3 (en) Human monoclonal antibodies against cd20
AP2359A (en) Sulfonamide derivatives for the treatment of diseases.
EA201590833A1 (en) ANTIBODIES FOR THE TREATMENT AND PREVENTION OF THE ALZGEIMER'S DISEASE AND THEIR APPLICATION
EP2103628A4 (en) Anti-claudin-3 monoclonal antibody, and treatment and diagnosis of cancer using the same
WO2009049184A9 (en) Systemic administration of chlorotoxin agents for the diagnosis and treatment of tumors
WO2007073478A8 (en) Genemap of the human genes associated with crohn's disease
EP2173373A4 (en) Soluble her2 and her3 splice variant proteins, splice-switching oligonucleotides, and their use in the treatment of disease
IL205398A0 (en) New antibodies specific of the ?? - amyloid peptides and their uses as diagnostic agents or drugs
WO2008120998A3 (en) Acoustically sensitive drug delivery particles
WO2008103920A3 (en) Targeted protein cages
ITTO20040410A1 (en) PROCEDURE FOR THE MANUFACTURE OF STRUCTURAL BEAMS IN COMPOSITE FOR AIRCRAFTS.
WO2007000320A3 (en) Method for diagnosing rheumatic diseases
NL1028599A1 (en) Compounds for the treatment of diseases.
WO2008075040A3 (en) Radioactive pet agents for imaging ccr5 in vivo
WO2007019865A3 (en) Therapy with cd4 binding peptides and radiation
WO2007059341A3 (en) Pyrazolothiazole protein kinase modulators

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08780591

Country of ref document: EP

Kind code of ref document: A2