WO2008135259A3 - Composition de molécules d'anticorps - Google Patents

Composition de molécules d'anticorps Download PDF

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Publication number
WO2008135259A3
WO2008135259A3 PCT/EP2008/003586 EP2008003586W WO2008135259A3 WO 2008135259 A3 WO2008135259 A3 WO 2008135259A3 EP 2008003586 W EP2008003586 W EP 2008003586W WO 2008135259 A3 WO2008135259 A3 WO 2008135259A3
Authority
WO
WIPO (PCT)
Prior art keywords
antibody molecule
molecule composition
heavy chain
light chain
variable
Prior art date
Application number
PCT/EP2008/003586
Other languages
English (en)
Other versions
WO2008135259A2 (fr
Inventor
Steffen Goletz
Original Assignee
Glycotope Gmbh
Steffen Goletz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glycotope Gmbh, Steffen Goletz filed Critical Glycotope Gmbh
Publication of WO2008135259A2 publication Critical patent/WO2008135259A2/fr
Publication of WO2008135259A3 publication Critical patent/WO2008135259A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne un anticorps comprenant au moins une chaîne lourde variable et une chaîne légère variable. La chaîne lourde variable est: QVQLKQSG PGLVQPSQSLS ITCTVSGFSLTNYGVHWVRQS PGKGLEWLGVIWS GGNTDYN TPFTSRLSiNKDNSKSQVFFKMNSLQSH Γ;TAI Y YCARALT YYDYEFAYWGQGTLVTVSTASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGP SVFLFPPKPKDTLMI SRTPEVTCVWDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNS 7YRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDEL TKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGS FFLYSKLTVDKSRWQ QGNVFSCSVMHEGLHNHYTQKSLSLSPGK; et/ou la chaîne légère variable est: DILLTQSPVILSVSPGERVSFSCRASQSIGTNIHWYQQRTKGSPRLLIKYASESISGIPS RFSGSGSGTDFTLSINSVESEDIADYYCQQNNNWPTTFGAGTKLELKRTVAAPSVFI FPP SDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLT LSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC.
PCT/EP2008/003586 2007-05-04 2008-05-05 Composition de molécules d'anticorps WO2008135259A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07090094.9 2007-05-04
EP07090094 2007-05-04

Publications (2)

Publication Number Publication Date
WO2008135259A2 WO2008135259A2 (fr) 2008-11-13
WO2008135259A3 true WO2008135259A3 (fr) 2009-04-09

Family

ID=39944059

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/003586 WO2008135259A2 (fr) 2007-05-04 2008-05-05 Composition de molécules d'anticorps

Country Status (1)

Country Link
WO (1) WO2008135259A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10759860B2 (en) 2014-09-16 2020-09-01 Synermore Biologics Co., Ltd. Anti-EGFR antibody and uses of same

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004085474A2 (fr) * 2003-03-20 2004-10-07 Imclone Systems Incorporated Procede de production d'un anticorps contre le recepteur du facteur de croissance epidermique
WO2005056606A2 (fr) * 2003-12-03 2005-06-23 Xencor, Inc Proteines optimisees qui ciblent le recepteur du facteur de croissance epidermique
WO2005080585A1 (fr) * 2004-02-13 2005-09-01 Glycotope Gmbh Conditions de traitement de glycoproteines extremement actives et methode efficace de production associee
WO2007041635A2 (fr) * 2005-10-03 2007-04-12 Xencor, Inc. Variants de fc dotés de propriétés de liaison aux récepteurs fc optimisées
WO2008028686A2 (fr) * 2006-09-10 2008-03-13 Glycotope Gmbh Système de production à haut rendement, entièrement humain, pour anticorps et protéines améliorés

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004085474A2 (fr) * 2003-03-20 2004-10-07 Imclone Systems Incorporated Procede de production d'un anticorps contre le recepteur du facteur de croissance epidermique
WO2005056606A2 (fr) * 2003-12-03 2005-06-23 Xencor, Inc Proteines optimisees qui ciblent le recepteur du facteur de croissance epidermique
WO2005080585A1 (fr) * 2004-02-13 2005-09-01 Glycotope Gmbh Conditions de traitement de glycoproteines extremement actives et methode efficace de production associee
WO2007041635A2 (fr) * 2005-10-03 2007-04-12 Xencor, Inc. Variants de fc dotés de propriétés de liaison aux récepteurs fc optimisées
WO2008028686A2 (fr) * 2006-09-10 2008-03-13 Glycotope Gmbh Système de production à haut rendement, entièrement humain, pour anticorps et protéines améliorés

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
QIAN ET AL: "Structural characterization of N-linked oligosaccharides on monoclonal antibody cetuximab by the combination of orthogonal matrix-assisted laser desorption/ionization hybrid quadrupole-quadrupole time-of-flight tandem mass spectrometry and sequential enzymatic digestion", ANALYTICAL BIOCHEMISTRY, ACADEMIC PRESS INC. NEW YORK, vol. 364, no. 1, 31 March 2007 (2007-03-31), pages 8 - 18, XP022005960, ISSN: 0003-2697 *

Also Published As

Publication number Publication date
WO2008135259A2 (fr) 2008-11-13

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